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Teses / dissertações sobre o tema "Hematopoiesis"

Autor: Grafiati

Publicado: 4 de junho de 2021

Última modificação: 25 de julho de 2025

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1

Javier, Jose Emmanuel F. "Increased TGF-beta Signaling Drives Different Hematopoietic Disease Outcomes following Stress Hematopoiesis." University of Cincinnati / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1617109578665394.

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2

Lin, Xionghui. "Hematopoiesis in a Crustacean." Doctoral thesis, Uppsala universitet, Jämförande fysiologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-121000.

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Hemocytes (blood cells) play an important role in the immune response in invertebrates, and thus the regulation of hemocyte homeostasis (hematopoiesis) is essential for the host survival against pathogens. Astakine 1, a homologue to vertebrate prokineticins, was first identified in the freshwater crayfish Pacifastacus leniusculus as a cytokine, and was found to be necessary for new hemocyte synthesis and release in vivo, and also to induce spreading and proliferation of Hematopoietic tissue cells (Hpt cells, precursor of hemocytes) in vitro. The work of this thesis is aimed to further our unde

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3

Benson, Eric Ashley. "Loss of SIMPL increases TNFalpha sensitivity during hematopoiesis." Connect to resource online, 2008. http://hdl.handle.net/1805/1851.

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Thesis (Ph. D.)--Indiana University, 2008.<br>Title from screen (viewed June 24, 2009). Department of Biochemistry and Molecular Biology, Indiana University-Purdue University Indianapolis (IUPUI). Advisor(s): Maureen Harrington. Includes vita. Non-Latin script record. Includes bibliographical references (leaves 126-132).

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4

Urbieta, Maitee. "Regulatory T Cells and Hematopoiesis in Bone Marrow Transplantation." Scholarly Repository, 2010. http://scholarlyrepository.miami.edu/oa_dissertations/463.

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CD4+CD25+FoxP3+ regulatory T cells (Treg) possess the capacity to modulate both adaptive and innate immunity. Due to their suppressive nature, Treg cells have been studied and tested in a variety of scenarios in an attempt to ameliorate undesired immune responses. While graft versus host disease (GVHD) has in fact emerged as the first clinical application for human Treg cells (Riley et al. 2009), equally important are issues concerning hematopoietic engraftment and immune reconstitution. Currently, little is known about the effect(s) that regulatory T cells may exert outside the immune system

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5

Syrjänen, R. (Riikka). "TIM family molecules in hematopoiesis." Doctoral thesis, Oulun yliopisto, 2014. http://urn.fi/urn:isbn:9789526204246.

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Abstract Hematopoietic cells, i.e., erythrocytes, platelets and white blood cells, differentiate from hematopoietic stem cells in a process that is similar in vertebrates. Hematopoiesis is regulated by molecules expressed by both the hematopoietic stem and progenitor cells and the surrounding microenvironments. Knowledge of these molecules is important since many of the genes involved in normal hematopoiesis are mutated in leukemia. Furthermore, this information can be utilized in more efficient isolation and expansion of hematopoietic cells in vitro. However, these molecules are not yet suffi

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6

Kuchenbauer, Florian. "MiRNAs in hematopoiesis and leukemogenesis." Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/16752.

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MicroRNAs (miRNAs) have been shown to play important roles in physiological as well as multiple malignant processes including acute myeloid leukemia (AML). In an effort to gain further insight into the role of miRNAs in AML, we have applied the Illumina massively parallel sequencing platform to carry out an in depth analysis of the miRNA transcriptome in a murine leukemia progression model, based on the engineered over-expression of the nucleoporin 98(NUP98)-homeobox HOXD13 fusion gene (ND13), followed by conversion into AML inducing cells upon transduction with the oncogenic collaborator Meis

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7

Hysenaj, Lisiena. "Alterations of hematopoiesis during brucellosis." Thesis, Aix-Marseille, 2019. http://www.theses.fr/2019AIXM0251.

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La brucellose est une maladie qui se transmet de l’animal à l’homme. Elle est causée par la bactérie Brucella. Lors de ma thèse, j’ai montré que Brucella persiste dans les cellules de la moelle osseuse des animaux infectés. Ces observations sont très importantes car la moelle est un organe responsable de la génération des cellules du système immunitaires et c’est la principale niche des cellules souches hématopoïétiques. Au cours de ma thèse, j'ai montré que la protéine de la membrane externe 25 de Brucella (Omp25) est capable de lier au récepteur SLAMF1, une molécule exprimée par les cellules

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8

Bilotkach, Kateryna. "Quest for early hematopoietic stem cell precursors." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/33056.

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The first transplantable hematopoietic stem cells (HSC) arise in the aorta-gonad mesonephros region (AGM) during early stages of embryo development. Specifically, ventral aspect of embryonic dorsal aorta (DA) contains HSC that upon transplantation into irradiated recipients can reconstitute all lineages of the haematopoietic system [Medvinsky et al. 1993; Muller and Medvinsky, 1994; Medvinsky and Dzierzak, 1996; Cumano et al., 1996; Tavian et al., 1996; Peault and Tavian, 2003; Taoudi and Medvinsky, 2007; Ivanovs et al., 2011, 2014]. The ventral aspect of DA bears so-called intra-aortic cell c

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9

Gronthos, Stan. "Stromal precursor cells : purification and the development of bone tissue." Title page, contents and abstract only, 1998. http://web4.library.adelaide.edu.au/theses/09PH/09phg8757.pdf.

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Bibliography: leaves 152-223. Experiments were designed to identify and purify human bone marrow stromal precursor cells by positive immunoselection, based on the cell surface expression of the VCAM-1 and STRO-1 antigens. The data presented demonstrates a hierarchy of bone cell development in vitro.

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10

Huang, Hsuan-Ting. "Epigenetic Regulation of Hematopoiesis in Zebrafish." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10175.

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The initiation of the hematopoietic program is orchestrated by key transcription factors that recruit chromatin regulators in order to activate or inhibit blood target gene expression. To generate a complete compendium of chromatin factors that establish the genetic code during developmental hematopoiesis, we conducted a large-scale reverse genetic screen targeting 425 chromatin factors in zebrafish and identified over 30 novel chromatin regulators that function at distinct steps of embryonic hematopoiesis. In vertebrates, developmental hematopoiesis occurs in two waves. During the first and p

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11

Liu, Jianing. "Molecular Modulators of Hematopoiesis and Leukemogenesis." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10206.

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Hematopoietic stem and progenitor cells proliferate and differentiate to reconstitute all lineages of functional blood cells. They are regulated by intricate cellular and molecular signals, on both genetic and epigenetic levels. Alterations in these regulatory signaling networks can lead to hematopoietic dysfunction, as well as transformation of hematopoietic cells and induction of leukemogenesis. This thesis focuses on uncovering molecular modulators that are crucial for the proper regulation of hematopoietic stem/progenitor cells. In Chapter II, I describe studies investigating functional ro

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12

Eshghi, Shawdee. "The roll of integrins in hematopoiesis." Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/39905.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Biological Engineering Division, 2007.<br>Includes bibliographical references (p. 113-123).<br>Hematopoietic stem cells (HSCs) hold great promise for the treatment of disease. The rare frequency at which HSCs occur in the bone marrow under homeostatic conditions is a limiting factor in both their study and clinical use. ex vivo expansion of these cells is therefore a necessary step to maximizing their potential. In this thesis I explore the concept that signals from the extracellular matrix can direct differentiation, survival and self-re

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13

Abraham, Brian J. "Systems biology approaches to understanding hematopoiesis." Thesis, Boston University, 2013. https://hdl.handle.net/2144/12703.

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Thesis (Ph.D.)--Boston University PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>Understanding gene expression and the regulation thereof that confer cell type-specific (CTS) functionality holds primary importance in devising therapeutics capable of emulating these functions, especially wit

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14

He, Liang. "Multiple Functions of Cables1 in Hematopoiesis." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS312.

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Cables1 est impliqué dans la régulation du cycle cellulaire et la survie. Par QPCR et western blot, Cables1 est fortement exprimé dans les cellules souches hématopoïétiques (CSH), les progéniteurs, les cellules de la niche médullaire et les mégakaryocytes. En utilisant un modèle de souris Cables1-/-, nous avons démontré que Cables1 est un régulateur clé de la maintenance homéostatique des CSH àl’état basal et sous stress hématopoïétique. Chez les souris jeunes dépourvues de Cables1, les progéniteurs hématopoïétiques sont hyperprolifératifs et ont un avantage compétitif de repeuplement. La sure

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15

Cheng, Yi-Han. "The development of surrogate marker-tagged ES cell technology to study haematopoietic commitment." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.607864.

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16

Merino, Juan Jiménez. "Circulatory stem cells of Styela plicata (Lesueur, 1823) (Tunicata: Stelidae): an evolutionary approach." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/41/41133/tde-18022019-090152/.

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Styelid ascidians are diverse in developmental modes, varying from strictly sexual solitary species to highly integrated colonies. Circulatory stem cells (CSCs) accomplish fundamental roles in developmental processes of styelid ascidians. In the colonial styelids, CSCs enable budding and are capable of giving origin to the germline in certain species. The function of these cells have been tested experimentally in models within Styelidae. However, the understanding of coloniality as an evolutionary novelty requires reconstructing the possible ancestral CSCs characteristics in Styelidae. To addr

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17

Imai, Takahiko. "Rap1 signal modulators control the maintenance of hematopoietic progenitors in bone marrow and adult long-term hematopoiesis." Kyoto University, 2019. http://hdl.handle.net/2433/243275.

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18

Dodson, Sarah Vanessa Meads. "Hematotoxicity of heptachlor." Morgantown, W. Va. : [West Virginia University Libraries], 2004. https://etd.wvu.edu/etd/controller.jsp?moduleName=documentdata&jsp%5FetdId=3799.

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Thesis (Ph. D.)--West Virginia University, 2004.<br>Title from document title page. Document formatted into pages; contains xi, 196 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references.

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19

Ullrich, Sebastian 1984. "Alternative mechanisms of gene regulation during hematopoiesis." Doctoral thesis, Universitat Pompeu Fabra, 2018. http://hdl.handle.net/10803/665801.

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Gene regulation orchestrates the development of different cell types and organs from the same genetic blueprint. While the basic mode of gene regulation is driven by transcription factors, there are a variety of other mechanisms that determine the amount of RNA produced per genes. In this work we first investigate specifically intron retention as a mode of alternative splicing that alters the cellular transcriptomes. As a model, we use hematopoiesis. We compare intron retention in different stages of human and mouse B-cell development to granulocyte differentiation. We further explore expressi

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20

Brooke-Bisschop, Travis. "The Role of Cdx in Primitive Hematopoiesis." Thesis, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/31580.

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Functional overlap and peri-implantation lethality have made the study of the Cdx family of transcription factors a challenging pursuit. Our research group has generated a conditional genetic knockout model that renders the murine embryo effectively Cdx null, allowing us to explore unknown developmental roles of Cdx. Previously uncharacterized hematopoietic defects are evident in these embryos, and with the use of ChIP-seq technology, a number of hematopoietic genes were identified as putative Cdx targets, including Scl, Lyl1, Lmo2, and Meis1. In addition, the chromatin remodeling protein Brg1

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21

Meng, Ronghua Pinkert Carl A. "Molecular mechanisms associated with canine cyclic hematopoiesis." Auburn, Ala, 2008. http://repo.lib.auburn.edu/EtdRoot/2008/SPRING/Biomedical_Sciences/Dissertation/Meng_Ronghua_9.pdf.

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22

Jordan, Stefan. "Modulation of extramedullary hematopoiesis during cytomegalovirus infection." Diss., Ludwig-Maximilians-Universität München, 2011. http://nbn-resolving.de/urn:nbn:de:bvb:19-177107.

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23

Watson, Alexander Scarth. "Autophagy in hematopoiesis and acute myeloid leukemia." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:2e66c5c3-4774-44d1-8345-d0dc827da16d.

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Acute myeloid leukemia (AML) develops following oncogenic alterations to hematopoietic stem (HSC) and progenitor cells (HSPCs) in the bone marrow, resulting in dysregulated proliferation of immature myeloid progenitors that interferes with normal hematopoiesis. Understanding the mechanisms of HSPC protection against damage and excessive division, and how these pathways are altered during leukemic progression, is vital for establishing effective therapies. Here, we show that autophagy, a lysosomal degradation pathway, is increased in HSPCs using a novel imaging flow cytometry autophagy assay. L

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24

Gomes, Ana Lúcia da Silva. "Cholestreol influence in normal and malignant hematopoiesis." Doctoral thesis, Instituto de Ciências Biomédicas Abel Salazar, 2009. http://hdl.handle.net/10216/45548.

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25

Ferrell, Scott A. "ARID3A binding sites and functions in hematopoiesis." Oklahoma City : [s.n.], 2009.

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26

Gomes, Ana Lúcia da Silva. "Cholestreol influence in normal and malignant hematopoiesis." Tese, Instituto de Ciências Biomédicas Abel Salazar, 2009. http://hdl.handle.net/10216/45548.

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27

Durand, Ellen Marie. "Regulation of hematopoietic stem cell migration and function." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11550.

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Hematopoietic stem cell transplantation (HSCT) is an effective treatment for blood disorders and autoimmune diseases. Following HSCT, these cells must successfully migrate to the marrow niche and replenish the blood system of the recipient. This process requires both non-cell and cell-autonomous regulation of hematopoietic stem and progenitor cells (HSPCs). A transgenic reporter line in zebrafish allowed the investigation of factors that regulate HSPC migration and function. To directly observe cells in their endogenous microenvironment, confocal live imaging was used to track runx1:GFP+ HSP

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28

Ding, Xiaolei [Verfasser]. "Polycomb protein Bmi1 in ES cell hematopoiesis and generation of iPSC from Flt3+ hematopoietic stem cells / Xiaolei Ding." Aachen : Hochschulbibliothek der Rheinisch-Westfälischen Technischen Hochschule Aachen, 2011. http://d-nb.info/101818824X/34.

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29

Chiou, Chuang-Jiun. "Expression of Granulocyte-Macrophage Colony-Stimulating Factor Gene in Insect Cells by a Baculovirus Vector." Thesis, University of North Texas, 1989. https://digital.library.unt.edu/ark:/67531/metadc798471/.

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The focus of this research is to describe the production and characterization of the human granulocyte-macrophage colony-stimulating factor (hGM-CSF) in insect cells, using Autographa californica buclear polyhedrosis virus (AcNPV) as an expression vector. All three forms of biological activity of hGM-CSF. Following N-glycanase treatment, the two glycosylated hGM-CSF proteins (15.5 and 16.5 KDa) which bound to Concanavalin A affinity column ran as a 14.5-15.5 KDa band on SDS-PAGE. Western blot analysis of expression in Sf9 cells treated with tunicamycin revealed only the presence of the 14.5 KD

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30

Jenkins, Brendan John. "Activating point mutations in the common ?gb?s[beta]-subunit of the human GM-CSF, IL-3 and IL-5 receptors : implications for receptor function and role in disease / by Brendan John Jenkins." Title page, contents and summary only, 1998. http://web4.library.adelaide.edu.au/theses/09PH/09phj518.pdf.

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31

Buchrieser, Julian. "Understanding human mononuclear phagocyte ontogeny using human induced pluripotent stem cells (iPSCs)." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:aaf18203-5f30-4d6a-8f51-3096b29af252.

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Tissue-resident macrophages (MΦ) such as microglia, Kupffer and Langerhans cells derive from Myb-independent yolk sac (YS) progenitors generated before the emergence of hematopoietic stem cells (HSCs). Myb-independent YS-derived resident MΦ self-renew locally, independently of circulating adult monocytes and HSCs. In contrast, adult blood monocytes as well as infiltrating, gut and dermal MΦ derive from Myb-dependent HSCs and are less proliferative. These findings are derived from the mouse, using gene knock-outs and lineage tracing, but their applicability to human development has

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32

Guiu, Sagarra Jordi 1983. "Notch activation and downstream targets in embryonic hematopoiesis." Doctoral thesis, Universitat Pompeu Fabra, 2012. http://hdl.handle.net/10803/98475.

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La regió de l’aorta-gonada-mesonefros (AGM) és el primer nínxol de les cèl·lules mare hematopoètiques. Està descrit que la via de Notch és necessària per generar artèries i cèl·lules mare hematopoètiques. Les cèl·lules mare hematopoètiques es generen a partir de les artèries durant el desenvolupament embrionari. Tenint en compte que els vasos arterials es formen abans que les cèl·lules mare hematopoètiques, durant molt temps ha estat controvertit si la via de Notch només indueix la formació d’artèries i en canvi l’abscència de cèl·lules mare hematopoètiques és un efecte secundari o si p

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33

Kim, Young-A. "Hematopoiesis, Kazal Inhibitors and Crustins in a Crustacean." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Universitetsbiblioteket [distributör], 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7123.

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34

Tan, Poh Choo. "Role of podocalyxin in hematopoiesis and cell migration." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/2860.

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CD34 and its relatives, Podocalyxin and Endoglycan, comprise of a family of surface sialomucins expressed by hematopoietic stem/progenitor cells, and vascular endothelia. Recent data suggest that they serve as either pro- or anti-adhesion molecules depending on their cellular context and their post-translational modifications. We were interested in identifying Podocalyxin ligands and their cellular distribution and understanding the role of these factors in signaling, adhesion and migration. Using both a lambda phage screen assay and mass spectrometry, we identified the Na⁺/H⁺ exchanger regula

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35

Kardel, Melanie Dawn. "Analysis of hematopoiesis from human pluripotent stem cells." Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/33333.

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Human embryonic stem (ES) or induced pluripotent stem (iPS) cells have the potential ability to generate all of the cell types in the body. If their differentiation into relevant cell types of interest can be effectively controlled, they are attractive for developmental studies, disease modelling, drug testing, and advancing regenerative medicine. The generation of hematopoietic cells from human ES/iPS cells has been reported, but is highly variable and often inefficient. My specific objective in this thesis was to more fully characterize the process whereby hematopoietic cells are generated f

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Martin, Richard. "Regulation of SCL expression and function in hematopoiesis." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=85582.

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The development of the hematopoietic system occurs in two waves: a first wave of primitive erythropoiesis, which consists in the production of a single lineage, primitive erythrocytes, and a second wave of definitive hematopoiesis, which describes the generation of many specialized blood cell types from common hematopoietic stem cells. Whereas definitive hematopoiesis is fairly well understood, involves signals from the environment and the expression of lineage-specific transcription factors, the molecular mechanisms regulating primitive erythropoiesis remain to be defined. The aim of t

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Taylor, Allison. "Ribosomal Protein Mutations in Hematopoiesis and Zebrafish Development." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10238.

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The focus of this thesis is the role of ribosomal proteins in hematopoiesis and development. Ribosomal proteins are mutated in patients with Diamond Blackfan anemia (DBA). These mutations primarily affect blood tissues, as DBA patients have a macrocytic anemia. We have identified hematopoietic defects in zebrafish with a mutation in ribosomal protein S29 (rps29). \(Rps29^{-/-}\) embryos have defects in hematopoietic stem cell formation, aorta specification, and hemoglobinization. Embryos also have increased numbers of apoptotic cells, and microarray analysis reveals up-regulation of a p53 gene

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Chen, Xiaoyi. "Role of autophagy in normal and malignant hematopoiesis." University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1490354914070478.

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Mon, Père Nathaniel. "Statistical biophysics of hematopoiesis and growing cell populations." Doctoral thesis, Universite Libre de Bruxelles, 2020. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/314684.

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Cell populations in the human body form highly complex systems, their behavior driven by countless processes within the cells themselves as well as their interactions with each other and their environment. A mathematical approach to describing their emergent phenomena on the tissue level typically requires abstractions of these underlying systems in order to obtain tractable and interpretable models, which in turn often leads to descriptions involving stochastic processes.In this doctoral thesis two such cellular systems are investigated. The first is the human hematopoietic system: the machin

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Bettigole, Sarah E. "Novel Functions for XBP1 and IRE1α in Hematopoiesis". Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17463152.

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The endoplasmic reticulum (ER) is a critical regulator of cellular homeostasis, primarily responsible for handling calcium storage and signaling, lipid synthesis, and the proper glycosylation and folding of nascent transmembrane and secreted proteins. Numerous stimuli such as dysregulated oxidative stress, depletion of calcium stores, hypo- and hyperglycemia, hypoxia, inefficient cellular degradation pathways, and inflammation can disrupt the protein folding capacity of the ER, leading to a condition known as ER stress. The canonical unfolded protein response (UPR) is a three-pronged signalin

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41

Althoff, Mark J. "Cell polarity in hematopoietic stem cell quiescence, signaling and fate determination." University of Cincinnati / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1583999632089058.

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42

Hogge, Donna Eileen. "Genetic investigations of human hemopoiesis : studies of clonality and gene transfer to hemopoietic progenitors." Thesis, University of British Columbia, 1987. http://hdl.handle.net/2429/27316.

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In most neoplasms malignant change occurs in a single cell which then proliferates. My purpose was to explore methods to study the cell that gives rise to hemopoietic cancer and to investigate the abnormalities at a molecular level. Cytogenetic analysis of cells from individual hemopoietic colonies revealed that monosomy 7 syndrome, a hematologic disorder of childhood, arises in a primitive cell capable of differentiating down both myeloid and erythroid pathways. Long-term bone marrow cultures (LTC) from patients with chronic myelogenous leukemia (CML) favor the growth of Philadelphia chromo

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43

Rode, Christina. "Cell type-specific Runx1 enhancer-reporter mouse lines to study hemogenic endothelium." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:49b91ea8-36a3-4bcd-8842-baa1ee31c7b9.

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Hematopoietic stem cells emerge from a specialized subset of endothelial cells in the midgestation mouse aorta. This subset, the so-called hemogenic endothelium (HE), undergoes a morphological and molecular change to a hematopoietic cell type, as part of the endothelial-to- hematopoietic transition (EHT). Previously, lack of specific markers prevented mechanistic studies of HE, as well as studies into its developmental origin. Runx1 is a critical regulator of developmental hematopoiesis and is expressed in all cell intermediates of EHT. Identification of the Runx1 +23 enhancer led to the devel

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44

Haylock, David Norman. "Ex vivo expansion of human haemopoietic progenitor cells." Title page, abstract and contents only, 2001. http://web4.library.adelaide.edu.au/theses/09PH/09phh4181.pdf.

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"December 2001." Includes bibliographical references (leaves 178-225) Focuses on the ex vivo growth of human haemopoietic progenitor cells with the objective of defining culture conditions for generating myeloid post-progenitor cells for therapy

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Shen, Ying. "The JAK/STAT pathway in Drosophila hematopoiesis: function and regulatory mechanisms." Ohio : Ohio University, 2007. http://www.ohiolink.edu/etd/view.cgi?ohiou1194628059.

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Hermida, Felipe Pessoa de Melo. "Células progenitoras CD34+ durante a ampliação esplênica na malária experimental de roedores." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/42/42135/tde-18102007-153435/.

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A malária é uma infecção causada por plasmódios, cujo controle depende do baço, o responsável pelo clareamento dos eritrócitos parasitos. O aumento da parasitemia induz uma ampliação do baço para resolver a infecção, onde participam células precursoras que apresentam CCD34+ na sua superfície. Estudamos a distribuição e a quantidade de células CD34+ em baços de roedores durante malárias de roedores, para compreender sua participação na ampliação do baço e no controle da infecção. Camundongos C57Bl/6j infectados com as cepas AJ e CR de Plasmodium chabaudi, e com a cepa ANKA de Plasmodium berghei

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Robert, Moreno Alexandre. "Role of Notch/RBPjk signaling pathaway in embryonic hematopoiesis." Doctoral thesis, Universitat de Barcelona, 2007. http://hdl.handle.net/10803/1055.

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The process that gives rise to all the mature blood cells from the HSCs (Hematopoietic Stem Cells) is known as hematopoiesis. In the adult, hematopoiesis takes place in the bone marrow although the HSCs are likely generated during embryonic life (reviewed in Cumano and Godin, Ann. Rev. Immunol 2007). Mouse embryonic hematopoiesis starts at embryonic day 7-7.5 in the extraembryonic yolk sac, whereas intraembryonic hematopoiesis starts at 9.5 in the aorta surrounded by gonad and mesonephros (a region known as AGM). The current knowledge is that both hematopoietic tissues can generate either pre-

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Andrés, Aguayo Luisa de. "The Role of Msi2 in adult and embryonic hematopoiesis." Doctoral thesis, Universitat Pompeu Fabra, 2017. http://hdl.handle.net/10803/586094.

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The life-long production of blood cells is enabled by hematopoietic stem and progenitor cells (HSPC) residing in the bone marrow. An understanding of the genes that control how HSPCs work to sustain the continued production of blood cells will enable new techniques to expand them for life-saving transplantation therapies. We have used a retroviral integration screen to search for novel genes that regulate hematopoietic stem cell (HSC) function. One of the genes found was Musashi 2 (Msi2), an RNA binding protein that can act as a translational inhibitor. A gene trap mouse model that inactivates

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Ripich, Tatsiana. "The novel function of SWAP-70 in hematopoiesis/erythropoiesis." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2009. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-25509.

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Abstract SWAP-70 originally identified as a signaling protein exclusively expressed in B-cells has been recently described in other cells of the hematopoietic system, such as mast cells and dendritic cells. Here we describe a novel role of SWAP-70 in hematopoiesis, specifically in regulation of erythropoiesis. SWAP-70 protein expression is detected at the stage of the hematopoietic stem cell (HSC). Its expression persists throughout several stages of multipotent and myeloid progenitors. In erythroid development SWAP-70 is found from early committed to erythroid lineage precursors, burst-formi

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Thorsteinsdottir, Unnur. "Functional analysis of selected Hox homeobox genes in hematopoiesis." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq25175.pdf.

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