Bibliografias temáticas / Hc427

Literatura científica selecionada sobre o tema "Hc427"

Autor: Grafiati
Publicado: 26 de julho de 2024
Última modificação: 27 de julho de 2024

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Artigos de revistas sobre o assunto "Hc427"

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Swartz, Adam, Kendra Congdon, Smita Nair, Qi-Jing Li, James Herndon, Carter Suryadevara, Katherine Riccione et al. "TMOD-14. CONJOINED CLASS I AND II EPITOPES ENHANCE NEOANTIGEN-TARGETED ACTIVE IMMUNOTHERAPY". Neuro-Oncology 23, Supplement_6 (2 de novembro de 2021): vi218. http://dx.doi.org/10.1093/neuonc/noab196.875.

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Abstract INTRODUCTION Cancer vaccines involve the administration of tumor-associated antigens into the host to generate anti-tumor T cell responses. Glioblastoma (GBM) is a disease with poor prognosis. GBM has a limited number of immunotherapeutic targets due to low mutational load, and is also highly heterogeneous; targeting a single antigen leads to antigen escape and tumor growth. METHODS VMDK mice were subcutaneously implanted with 750,000 SMA560 cells and on days 1 and 8 post implantation, mice were treated with 15 nmol of the universal helper epitope, P30, conjoined to the MHCI-restricted neoepitopes Odc1MHCI-P30 or Topbp1MHCI-P30. Human CD27 (hCD27) transgenic mice were intracranially implanted with CT2A-Odc1, followed by anti-CD27 and 15 nmol of Odc1MHCI-P30. B16.OVA or B16.F10 tumor cells were intracranially implanted in hCD27 mice and received SIINFEKL-P30 or Trp2-P30 conjoined peptides. Tumor growth, survival, or IFNγ secretion of splenic or tumor-infiltrating cells was assessed. RESULTS Unlike Odc1MHCI mixed with P30, conjoined Odc1MHCI-P30 had equivalent immunogenicity and anti-tumor efficacy to that observed with native long Odc1 peptide. Native long peptide of Topbp1 did not elicit an antitumor response, yet Topbp1MHCI-P30 caused an increase in numbers of IFNγ-secreting splenocytes and a decrease in tumor growth and similar to that seen with Odc1MHCI-P30 . Anti-CD27 treatment significantly increased numbers of IFNγ secreting splenocytes in Odc1MHCI-P30 vaccinated hCD27 mice, and the use of anti-CD27 with Odc1MHCI-P30 achieved long-term survival in 90% of tumor bearing hCD27 mice. Anti-CD27 synergized with SIINFEKL-P30 and Trp2-P30 to significantly improve survival after administration of these peptides. CONCLUSIONS Our work shows that poorly immunogenic neoantigens can be conjoined to P30 and used to generate an anti-tumor response in mouse models of GBM, and anti-tumor responses of conjoined peptides can be enhanced with anti-CD27 treatment. Together, these data demonstrate the efficacy of neoantigen vaccines for the treatment of heterogeneous GBM.
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Forsberg, Eric, Li-Zhen He, Kathleen Borrelli, James Boyer, Lauren Gergel, Catherine Pilsmaker, Sarah Round et al. "Therapeutic efficacy of a fully human anti-CD27 monoclonal antibody in a murine colon carcinoma model (162.23)". Journal of Immunology 188, n.º 1_Supplement (1 de maio de 2012): 162.23. http://dx.doi.org/10.4049/jimmunol.188.supp.162.23.

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Abstract The costimulatory molecule CD27 is constitutively expressed on the majority of mature T cells, memory B cells, and a portion of NK cells. The interaction of CD27 with its ligand CD70 plays an important role in effector capacity and memory in T cells; in clonal B cell expansion and germinal center formation; and in NK cell cytolytic activity. Agonistic anti-mouse CD27 mAbs have been shown to have potent anti-tumor activity. A panel of fully human antibodies recognizing human CD27 was generated and we have previously shown that our lead clone (1F5) can mediate anti-tumor effects using the BCL1 B-lymphoma line in human CD27-transgenic (hCD27-Tg) mice. In order to further investigate the mechanism of this anti-hCD27 monoclonal and its activity in a therapeutic setting we assessed anti-tumor activity using the CT26 murine colon carcinoma line. CT26 cells were delivered s.c. to hCD27-Tg animals and five doses of 1F5 were delivered to mice i.p. beginning on days 3, 5, or 7. In multiple experiments, tumor growth in mice treated with 1F5 was substantially delayed or prevented compared to that of control-treated mice. When 1F5-treated surviving mice were rechallenged with CT26 cells, without additional anti-CD27 antibody treatment, tumors did not grow in most animals. These data support the continued clinical development of this anti-CD27 mAb to enhance immune responses in cancer therapy. Investigations of immune cell subset depletions and combination therapies are ongoing.
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Nehbandani, Alireza, Afshin Soltani, Reza Taghdisi Naghab, Amir Dadrasi e Seyyed Majid Alimagham. "Assessing HC27 Soil Database for Modeling Plant Production". International Journal of Plant Production 14, n.º 4 (2 de setembro de 2020): 679–87. http://dx.doi.org/10.1007/s42106-020-00114-4.

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Fischione, Piera, Daniele Celli, Davide Pasquali, Gabriel Barajas, Benedetto Di Paolo e Javier L. Lara. "Inside a Beach Drainage System: A Three-Dimensional Modeling". International Journal of Offshore and Polar Engineering 33, n.º 2 (1 de junho de 2023): 196–203. http://dx.doi.org/10.17736/ijope.2023.hc27.

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Guillaudeux, Thierry, Yulia Ovechkina, Kurt Lustig e Shawn Iadonato. "Abstract B034: CD27 is a new promising T cell co-stimulatory target for cancer immunotherapy". Cancer Immunology Research 11, n.º 12_Supplement (1 de dezembro de 2023): B034. http://dx.doi.org/10.1158/2326-6074.tumimm23-b034.

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Abstract Members of the tumor necrosis factor receptor superfamily (TNFRSF) are key co-stimulators of T cells. CD27, a member of the TNFRSF, is expressed only on the surface of lymphocytes, including naive and activated CD4+ and CD8+ T cells as well as NK cells. It enhances T cell activation, proliferation, and differentiation of effector and memory T cells after stimulation with its ligand, CD70. The costimulatory signal of CD27 is mediated via the NFkB pathway but also via the phosphatidylinositol 3 kinase and the protein kinase B pathways. CD27 signaling also influences the innate immune response via direct activation of NK cells and subsequent secretion of interferon-gamma (IFNg). Several published preclinical studies demonstrated that anti-CD27 agonistic monoclonal antibodies can promote T-cell activation and antitumor immunity making CD27 an attractive cancer immunotherapy target. Here we describe the characterization, preclinical development, and selection of our anti-CD27 fully human monoclonal antibody (mAb) lead candidate. We selected this candidate from a library of 147 anti-CD27 mAbs generated after immunization of humanized Trianni® mice with soluble human CD27 extracellular domain (hCD27-ECD). Anti-CD27 mAbs were tested in an accelerated stability study and showed excellent stability parameters for up to 7 days at 4 and 37°C in commonly used formulation buffers. The selected agonist anti-CD27 mAb demonstrated high affinity binding to both human and cynomolgus monkey CD27 and not to mouse CD27. It also demonstrated high specificity against CD27 with no cross-reactivity detected against other members of the TNFRSF. This lead candidate did not block the binding of CD27 natural ligand, CD70 and induced strong NFkB-mediated CD27 signaling in the absence or presence of cross-linking by Fc gamma receptors or secondary cross-linking antibodies. Moreover, this anti-CD27 mAb mediated NFkB activation is significantly potentiated by the addition of a sub-optimal amount of soluble CD70. The anti-CD27 lead mAb induced T cell proliferation and secretion of pro-inflammatory cytokines only in the presence of sub-optimal TCR stimulation in vitro using primary human T cells. It also activated NK cells demonstrated by CD69 expression induction. The anti-CD27 mAb lead candidate showed extended serum half-life in hCD27-KI mice. It also demonstrated a significant antitumor effect as a single agent in human CD27-Knockin mice (hCD27-KI) subcutaneously implanted with MC38 or in NOD-SCID mice subcutaneously implanted with Raji. These preclinical results establish that the selected anti-CD27 mAb is a promising drug candidate and we are actively pursuing its development. Citation Format: Thierry Guillaudeux, Yulia Ovechkina, Kurt Lustig, Shawn Iadonato. CD27 is a new promising T cell co-stimulatory target for cancer immunotherapy [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: Tumor Immunology and Immunotherapy; 2023 Oct 1-4; Toronto, Ontario, Canada. Philadelphia (PA): AACR; Cancer Immunol Res 2023;11(12 Suppl):Abstract nr B034.
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Widdess, Marcus A., H. T. Claude Chan, Christine A. Penfold, C. Ian Mockridge, Tatyana Inzhelevskaya, Hannah J. Metcalfe, Mark S. Cragg e Aymen Al-Shamkhani. "Abstract A26: Tetravalency endows anti-CD27 antibodies with enhanced co-stimulatory activity and anti-tumour immune responses". Cancer Immunology Research 10, n.º 12_Supplement (1 de dezembro de 2022): A26. http://dx.doi.org/10.1158/2326-6074.tumimm22-a26.

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Abstract Immunostimulatory antibodies targeting co-stimulatory TNFRSF members have shown promise in pre-clinical cancer models, but this has not translated into clinical success, primarily due to lack of efficacy. Oligomerisation of the co-stimulatory molecule CD27 by its trimeric membrane-bound ligand activates NF-κB and AP1 signalling leading to enhanced CD8 T cell responses in both humans and mice. Targeting CD27 with bivalent mAb may lead to sub-optimal receptor oligomerisation and inefficient T cell activation. Here we present a general approach to improve the potency of anti-CD27 mAb. We engineered tetravalent forms of anti-CD27 antibodies targeting both mouse and human CD27 by attaching two additional Fab fragments to the N-terminus of the of the IgG VH domain. These tetravalent mAb had greater avidity to CD27 and were more potent than their bivalent counterparts in stimulating NF-κB activation and T cell proliferation in vitro, with optimal responses requiring antibody crosslinking by FcγRIIb. In addition, confocal microscopy of hCD27-GFP fusion protein expressing Jurkat T cells showed that tetravalent anti-hCD27 mAb triggered receptor clustering more efficiently than the equivalent bivalent mAb, as evidenced by the increased number of receptor clusters on the cell surface. Importantly, tetravalent anti-CD27 mAb induced greater CD8 T cell responses than the bivalent mAb in a vaccination model and was more efficacious in suppressing tumour growth in vivo. This work demonstrates that the agonistic activity of anti-CD27 mAb can be significantly improved by tetravalency and suggest that this approach could be utilised to enhance the therapeutic activity of mAb targeting other members of the TNFRSF. Citation Format: Marcus A Widdess, H. T. Claude Chan, Christine A Penfold, C Ian Mockridge, Tatyana Inzhelevskaya, Hannah J Metcalfe, Mark S Cragg, Aymen Al-Shamkhani. Tetravalency endows anti-CD27 antibodies with enhanced co-stimulatory activity and anti-tumour immune responses [abstract]. In: Proceedings of the AACR Special Conference: Tumor Immunology and Immunotherapy; 2022 Oct 21-24; Boston, MA. Philadelphia (PA): AACR; Cancer Immunol Res 2022;10(12 Suppl):Abstract nr A26.
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Riccione, Katherine, Luis Sanchez-Perez, Catherine Flores e John Sampson. "Characterization of a human CD27 agonistic monoclonal antibody for use as an agent in glioblastoma therapy (P4411)". Journal of Immunology 190, n.º 1_Supplement (1 de maio de 2013): 205.15. http://dx.doi.org/10.4049/jimmunol.190.supp.205.15.

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Abstract CD27 is a costimulatory molecule constitutively expressed on naïve T-cells, B-cells, and subsets of NK cells; signaling through CD27 has been shown to promote Th1 polarization, clonal expansion, enhanced survival of effector and memory cells, upregulation of effector molecules, and enhanced cytolytic activity. We are characterizing the use of an agonistic anti-CD27 antibody, CDX1127, as a treatment in a preclinical glioblastoma model in human CD27 transgenic mice. We have shown that in vitro stimulation of isolated T-cells from hCD27+/- mice with CDX1127, in the context of TCR signaling, leads to increased proliferation, decreased apoptosis, and increased secretion of IFN-γ and TNF-α, corroborating its agonistic activity. Furthermore, we have analyzed the efficacy of CDX1127 as a monotherapy in a mouse glioblastoma model as well as an adjuvant in a total tumor RNA dendritic cell vaccine.
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Yang, Xiaoyong, e Tan Jin. "Fractal calculation method of friction parameters: Surface morphology and load of galvanized sheet". Open Physics 19, n.º 1 (1 de janeiro de 2021): 375–82. http://dx.doi.org/10.1515/phys-2021-0042.

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Abstract In the forming process of galvanized sheet, the friction between the die and the blank often causes the zinc coating of galvanized sheet to peel off, scratch, and crack. The aim of this study is to evaluate and calculate the fractal characteristics of the surface morphology of galvanized sheet and the effect of pressure on the interfacial friction behavior. Two steel plates, GA and GI, produced by Shanghai Baosteel Company, were used as materials to conduct tribological experiments, measure the surface profile and three-dimensional shape of the galvanized sheet, and calculate the fractal dimension and fractal roughness parameters. According to the analysis results of friction surface damage of galvanized sheet, the damage failure parameters of galvanized sheet are calculated. On this basis, according to the adhesive friction theory, the total surface friction value of galvanized sheet is obtained, and the fractal calculation model of galvanized sheet friction is established. The simulation results show that the galvanized sheet has fractal characteristics. The average values of fractal dimension and scale factor of SP781BQ alloy hot-dip galvanized sheet are 1.52 and 0.23 µm, respectively. The average fractal dimension and scale coefficient of HC420/780DPD + Z hot-dip galvanized sheet are 1.60 and 0.11 µm, respectively. The friction coefficient calculated by the proposed method is consistent with the theoretical value, and the error is less than 10%, which proves the accuracy and feasibility of the friction fractal calculation method.
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Kheloufi, Farid, Isabelle Poizot-Martin, Rodolphe Garraffo, Aude Tavenard, Sylvie Quaranta, Alain Renault, Thibault Lavrut et al. "ITPA deficiency and ribavirin level are still predictive of anaemia in HCV–HIV-coinfected patients receiving ribavirin combined with a first-generation DAA (ANRS HC27 study)". Antiviral therapy 22, n.º 6 (2016): 461–69. http://dx.doi.org/10.3851/imp3074.

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Poizot-Martin, Isabelle, Eric Bellissant, Rodolphe Garraffo, Philippe Colson, Lionel Piroth, Caroline Solas, Alain Renault et al. "Addition of boceprevir to PEG-interferon/ribavirin in HIV-HCV-Genotype-1-coinfected, treatment-experienced patients: efficacy, safety, and pharmacokinetics data from the ANRS HC27 study". HIV Clinical Trials 17, n.º 2 (11 de fevereiro de 2016): 63–71. http://dx.doi.org/10.1080/15284336.2015.1135553.

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Teses / dissertações sobre o assunto "Hc427"

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Machmud, Teuku Mohammad Arief Sjakur. "Determinants of inflation in Indonesia : an econometric analysis". Phd thesis, 2008. http://hdl.handle.net/1885/151195.

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Soejachmoen, Moekti Prasetiani. "Why is Indonesia left behind in global production networks?" Phd thesis, 2012. http://hdl.handle.net/1885/150394.

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International trade in electronics and automotive including their parts and components has grown rapidly in the last two decades, but Southeast Asia's largest economy, Indonesia, is lagging behind in its export performance. This research uses a comparative perspective in examining Indonesia's role in electronics and automotive production networks in the context of the contemporary debate on opportunities for reaping gains from economic globalization through engagement in global production networks. This research aims to answer two questions, the first addresses the determinants of a country's participation in the global production network; the second is why Indonesia is being left behind in the global production networks. To the best of the author's knowledge, this study is the first systematic analysis to determine why Indonesia has been left behind in global production networks. The analysis is conducted at two levels: macroeconomic and firm-level analysis. The macroeconomic analysis is based on the Jones and Kierzkowski's fragmentation theory. The unbalanced panel trade data for 98 countries for the period 1988-2007 for the electronics and automotive sectors are estimated using the least square dummy variable method. Meanwhile, the firm-level analysis is based on Robert and Tybout's model on firm heterogeneity and its implications for international trade. The random effect probit dynamic model is adopted for the estimation using Indonesia's firm level data for the both sectors for the period 1990 - 2007. From the macroeconomic analysis, the service link cost variables are a more important determinant than the production cost variables in determining a country's participation. Infrastructure is the most important determinant in developing countries for both sectors, followed by labour quality and FDI openness. For developed countries, trade openness is the most important determinant in the electronics sector and trade cost the most important in the automotive sector. For both, the second most important is labour quality in the electronics sector and infrastructure in the automotive. Indonesia is being left behind in the electronics global production network because of the poor condition of its infrastructure; the relatively more restrictive investment policies towards foreign investment, and the low education level which hampers the absorption capacity in technology which is important in the electronics sector. With the huge domestic market in Indonesia which creates economies of scale, it is expected that the Indonesian automotive industry could participate more in the global production network than it does in its current condition. However its participation is hampered because of its investment policies, trade costs and the continuing high protection in the automotive sector. From the firm-level analysis, a decision to engage in the global production networks through export activities depends on firm characteristics as well as sunk cost and a location spillovers effect. For both electronics and automotive sectors, larger and foreign owned firms with higher labour quality and located in similar locations are more likely to participate in the production networks. It is concluded that Indonesia needs to improve its infrastructure condition, investment policies and education level to increase its participation in the global production networks. -- provided by Candidate.
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Vidyattama, Yogi. "Patterns of provincial economic growth in Indonesia". Phd thesis, 2008. http://hdl.handle.net/1885/151245.

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Anas, Titik. "Behind the boom and bust of Indonesian exports". Phd thesis, 2012. http://hdl.handle.net/1885/149656.

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This thesis examines Indonesia's export performance from the 1970s. It provides a rigorous and comprehensive analysis of the currently limited discussion on Indonesia's trade issues. The main research questions are threefold: how good is Indonesia's export performance over the last 30 years?. How does it compare to its close competitors?. What factors contributed to the performance? This thesis begins with a discussion of the economic policy dynamics in Indonesia since the 1970s and focuses on the economic reforms Indonesia has undertaken since the mid 1980s, followed by chapters devoted to discussion on Indonesia's comparative advantage and competitiveness relative to its close competitors and the determinants of exports, at the macro and firm levels. On comparative advantage, this thesis shows that the number of products for which Indonesia has a comparative advantage has increased over time. The increase is mainly due to the manufacturing sector. A closer assessment of the manufacturing sector confirms Indonesia's comparative advantage in labour intensive and resource based labour intensive industries. However, recent data show these industries experienced deterioration in their export strength. On Indonesia's competitive position relative to China, Malaysia, Thailand and Viet Nam, this thesis shows Indonesia is more competitive in the agriculture sector especially in recent times; relatively less competitive in the manufacturing sector; and on a par in the mining sectors except for the last few years when Indonesia has been relatively more competitive. Closer assessment of the manufacturing sector reveals that Indonesia is relatively more competitive in resource based labour intensive and resource based capital-intensive industries. This thesis also shows the long run relationship between exports, the real exchange rate, and demand and supply factors. The signs and the magnitude of the effect of each of the factors differ across sectors and subsectors. For manufacturing exports, the real exchange rate, demand and supply factors are positive and statistically significant. For agriculture exports, the effect of real exchange rate, world demand and supply capacity are also positive. However, only coefficients of world demand and supply capacity are statistically significant. For the mining sectors, although those three variables exhibit positive impacts on exports, only world demand shows a statistically significant impact. This chapter also shows the particular impact of economic reform on the manufacturing sector. It also shows differences in exports performance across sector during the crisis. At the firm level, this thesis shows the impact of firm heterogeneity and spillovers on export decisions and export performance. The results are relatively consistent for pre and post-crisis period. On the export decisions, the effect of labour productivity, size, foreign ownership, sectoral and regional spillovers are positive. On export performance, the effect of firm heterogeneity and spillovers are also relatively consistent for pre and post-crisis, while the magnitudes are generally higher during the post-crisis period, except for sectoral spillovers. Assessment of the labour-intensive sector shows their superior export performance compared to other manufacturing exports. The assessment on Batam also reveals its superior export performance relative to other regions. --provided by Candidate.
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Ohori, Kana. "The effectiveness of Japanese official development assistance in Indonesia". Thesis, 2009. http://hdl.handle.net/1885/148267.

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Ponomareva, Natalia. "Issues in the choice of a monetary policy regime for an emerging market economy : the case of Korea". Phd thesis, 2005. http://hdl.handle.net/1885/151254.

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Lama, Chhewang Namgel. "Forests, yak and people : changing institutional arrangements for highland natural resource management in Solu-Khumbu, Nepal". Phd thesis, 2004. http://hdl.handle.net/1885/150992.

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Hannigan, Lisa. "Addressing chronic poverty in remote rural areas through social protection : a case study of workfare in Nepal". Master's thesis, 2007. http://hdl.handle.net/1885/148191.

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Livros sobre o assunto "Hc427"

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Great Britain. Parliament. House of Commons. Home Affairs Committee. Freemasonry in public life: The Government reply to the Second Report from the Home Affairs Committee, session 1998-99, HC467. London: The Stationery Office, 2000.

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Trade & Industry Committee. Replies from the Government and from the Director General of Fair Trading to the 6th Report from the Trade and Industry Committee, Session 1995-96, on ... Retailing (HC527). Stationery Office Books, 1997.

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Relatórios de organizações sobre o assunto "Hc427"

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NIOSH Hazard Controls HC27 - New shroud design controls silica dust from surface mine and construction blast hole drills. U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, novembro de 1998. http://dx.doi.org/10.26616/nioshpub98150.

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