Artigos de revistas sobre o tema "Global Change National Program (U.S.)"

<p>A quarter century ago the landmark report from the U. S. National Academies of Sciences, Engineering, and Medicine entitled <em>“</em><em>Emerging Infections, Microbial Threats to Health in the United States” </em>was released. This classic study captured the societal changes then underway in our rapidly growing world: The growth of the world’s population and changing human behavior; the advances and globalization of technology and industry; the changes in economic development and land use; the dramatic increase in speed and frequency of international travel and commerce; the adaptation of microbes and the appearance of never before seen pathogens; and the breakdown of traditional public health measures. This societal evolution has only increased and the growing frequency of outbreaks foretold in the report has come to pass. Each new disaster has precipitated changes and adaptations in our global response to infectious diseases designed to reduce risks and avoid future outbreaks. We discuss these past events and how each led to change in an effort to mitigate future threats. We also look to the future to consider what challenges might lay ahead.</p><p><strong>Conclusion. </strong>Major outbreaks over the past quarter century validated the concept of emerging infectious diseases and led to improvements in global policies and national public health programs; however, there will likely always be new diseases and the threat of reemergence of diseases once thought controlled leading to a constant need for vigilance in public health preparedness.</p>

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The Covid-19 pandemic had a dangerous impact on early-childhood education, lost learning in almost all aspects of child development. The house-to-house learning, with the name Moving Home Learning Program (MHLP), is an attractive offer as an emergency remote teaching solution. This study aims to describe the application of MHLP designed by early-childhood education institutions during the learning process at home. This study used a qualitative approach with data collection using interviews, observation, and documentation. The respondents involved in the interview were a kindergarten principal and four teachers. The research data were analyzed using the data content analysis. The Findings show that the MHLP has proven to be sufficiently in line with the learning needs of early childhood during the Covid-19 pandemic. Although, the application of the MHLP learning model has limitations such as the distance from the house that is far away, the number of meetings that are only once a week, the number of food and toy sellers passing by, disturbing children's concentration, and the risk of damage to goods at home. The implication of this research can be the basis for evaluating MHLP as an adaptive strategy that requires the attention of related parties, including policy makers, school principals, and teachers for the development of new, more effective online learning models. Keywords: Moving Home Learning Program (MHLP), Children Remote Teaching References:Abdollahi, E., Haworth-Brockman, M., Keynan, Y., Langley, M. J., & Oghadas, S. M. (2020). Simulating the effect of school closure during COVID-19 outbreaks in Ontario , Canada. BMC Medicine, 1–8. https://doi.org/https://doi.org/10.1186/s12916-020-01705-8 Arends, R. I., & Kilcher, A. (2010). 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Curriculum material is generally considered the subject matter of information, talents, dispositions, understandings, and principles that make up research programs in the field. At a more complex level, the curricula need to contain historical and socio-political strengths, traditions, cultural views, and goals with wide differences in sovereignty, adaptation, and local understanding that encompass a diversity of cultures, laws, metaphysics, and political discourse This study aims to develop a curriculum with local content as a new approach in early childhood science learning. The Local Content Curriculum (LCC) is compiled and developed to preserve the uniqueness of local culture, natural environment, and community crafts for early childhood teachers so that they can introduce local content to early childhood. Research and model development combines the design of the Dick-Carey and Dabbagh models with qualitative and quantitative descriptive analysis. The results showed that local content curriculum products can be supplemented into early childhood curricula in institutions according to local conditions. Curricula with local content can be used as a reinforcement for the introduction of science in early childhood. The research implication demands the concern of all stakeholders to see that the introduction of local content is very important to be given from an early age, so that children know, get used to, like, maintain, and love local wealth from an early age. Keywords: Early Childhood, Scientific Learning, Local Content Curriculum Model References: Agustin, R. S., & Puro, S. (2015). Strategy Of Curriculum Development Based On Project Based Learning (Case Study: SMAN 1 Tanta Tanjung Tabalong South Of Kalimantan ) Halaman : Prosiding Ictte Fkip Uns, 1, 202–206. Agustina, N. Q., & Mukhtaruddin, F. (2019). The Cipp Model-Based Evaluation on Integrated English Learning (IEL) Program at Language Center. English Language Teaching Educational Journal, 2(1), 22. https://doi.org/10.12928/eltej.v2i1.1043 Altinyelken, H.K. (2015). Evolution of Curriculum Systems to Improve Learning Outcomes and Reduce Disparities in School Achievement, in Background paper prepared for the Education for All Global Monitoring Report 2015. Andrian, D. (2018). International Journal of Instruction. 11(4), 921–934. Andrian, D., Kartowagiran, B., & Hadi, S. (2018). The instrument development to evaluate local curriculum in Indonesia. International Journal of Instruction, 11(4), 921–934. https://doi.org/10.12973/iji.2018.11458a Aslan, Ö. M. (2018). From an Academician’ s Preschool Diary: Emergent Curriculum and Its Practices in a Qualified Example of Laboratory Preschool. 7(1), 97–110. https://doi.org/10.5430/jct.v7n1p97 Bakhtiar, A. M., & Nugroho, A. S. (2016). Curriculum Development of Environmental Education Based on Local Wisdom at Elementary School. 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<p><strong>1. How can we maintain a sustainable private practice in the current political and economic climate?</strong></p><p>Eugene Allers</p><p><strong>2. SASOP Clinical guidelines, protocols and algorithms: Development of treatment guidelines for bipolar mood disorder and major depression</strong></p><p> Eugene Allers, Margaret Nair, Gerhard Grobler</p><p><strong>3. The revolving door phenomenon in psychiatry: Comparing low-frequency and high-frequency users of psychiatric inpatient services in a developing country</strong></p><p>U A Botha, P Oosthuien, L Koen, J A Joska, J Parker, N Horn</p><p><strong>4. Neurophysiology of emotion and senses - The interface between psyche and soma</strong></p><p>Eugene Allers</p><p><strong>5. Suicide prevention: From and beyond the psychiatrist's hands</strong></p><p>O Alonso Betanourt, M Morales Herrera</p><p><strong>6. Treatment of first-episod psychosis: Efficacy and toleabilty of a long-acting typical antipsychotic </strong></p><p>B Chiliza, R Schoeman, R Emsey, P Oosthuizen, L KOen, D Niehaus, S Hawkridge</p><p><strong>7. Treatment of attention deficit hyperactivity disorder in the young child</strong></p><p>Helen Clark</p><p><strong>8. Holistic/ Alternative treatment in psychiatry: The value of indigenous knowledge systems in cllaboration with moral, ethical and religious approaches in the military services</strong></p><p>J Dill</p><p><strong>9. Treating Schizophrenia: Have we got it wrong?</strong></p><p>Robin Emsley</p><p><strong>10.Terminal questions in the elderly</strong></p><p>Mike Ewart Smith</p><p><strong>11. Mental Health Policy development and implementation in Ghana, South Africa, Uganda and Zambia</strong></p><p>Alan J Flisher, Crick Lund, Michelle Frank, Arvin Bhana, Victor Doku, Natalie Drew, Fred N Kigozi, Martin Knapp, Mayeh Omar, Inge Petersen, Andrew Green andthe MHaPP Research Programme Consortium</p><p><strong>12. What indicators should be used to monitor progress in scaling uo services for people with mental disorders?</strong></p><p>Lancet Global Mental Health Group (Alan J Flisher, Dan Chisholm, Crick Lund, Vikram Patel, Shokhar Saxena, Graham Thornicroft, Mark Tomlinson)</p><p><strong>13. Does unipolar mania merit research in South Africa? A look at the literature</strong></p><p>Christoffel Grobler</p><p><strong>14. Revisiting the Cartesian duality of mind and body</strong></p><p>Oye Gureje</p><p><strong>15. Child and adolescent psychopharmacology: Current trends and complexities</strong></p><p>S M Hawkridge</p><p><strong>16. Integrating mental illness, suicide and religion</strong></p><p>Volker Hitzeroth</p><p><strong>17. Cost of acute inpatient mental health care in a 72-hour assessment uniy</strong></p><p>A B R Janse van Rensburg, W Jassat</p><p><strong>18. Management of Schizophrenia according to South African standard treatment guidelines</strong></p><p>A B R Janse van Rensburg</p><p><strong>19. Structural brain imaging in the clinical management of psychiatric illness</strong></p><p>F Y Jeenah</p><p><strong>20. ADHD: Change in symptoms from child to adulthood</strong></p><p>S A Jeeva, A Turgay</p><p><strong>21. HIV-Positive psychiatric patients in antiretrovirals</strong></p><p>G Jonsson, F Y Jeenah, M Y H Moosa</p><p><strong>22. A one year review of patients admitted to tertiary HIV/Neuropsychiatry beds in the Western Cape</strong></p><p>John Joska, Paul Carey, Ian Lewis, Paul Magni, Don Wilson, Dan J Stein</p><p><strong>23. Star'd - Critical review and treatment implications</strong></p><p>Andre Joubert</p><p><strong>24. Options for treatment-resistent depression: Lessons from Star'd; an interactive session</strong></p><p>Andre Joubert</p><p><strong>25. My brain made me do it: How Neuroscience may change the insanity defence</strong></p><p>Sean Kaliski</p><p><strong>26. Child andadolescent mental health services in four African countries</strong></p><p>Sharon Kleintjies, Alan Flisher, Victoruia Campbell-Hall, Arvin Bhana, Phillippa Bird, Victor Doku, Natalie, Drew, Michelle Funk, Andrew Green, Fred Kigozi, Crick Lund, Angela Ofori-Atta, Mayeh Omar, Inge Petersen, Mental Health and Poverty Research Programme Consortium</p><p><strong>27. Individualistic theories of risk behaviour</strong></p><p>Liezl Kramer, Volker Hitzeroth</p><p><strong>28. Development and implementation of mental health poliy and law in South Africa: What is the impact of stigma?</strong></p><p>Ritsuko Kakuma, Sharon Kleintjes, Crick Lund, Alan J Flisher, Paula Goering, MHaPP Research Programme Consortium</p><p><strong>29. Factors contributing to community reintegration of long-term mental health crae users of Weskoppies Hospital</strong></p><p>Carri Lewis, Christa Kruger</p><p><strong>30. Mental health and poverty: A systematic review of the research in low- and middle-income countries</strong></p><p>Crick Lund, Allison Breen, Allan J Flisher, Ritsuko Kakuma, Leslie Swartz, John Joska, Joanne Corrigall, Vikram Patel, MHaPP Research Programe Consortium</p><p><strong>31. The cost of scaling up mental health care in low- and middle-income countries</strong></p><p>Crick Lund, Dan Chishlom, Shekhar Saxena</p><p><strong>32. 'Tikking'Clock: The impact of a methamphetamine epidemic at a psychiatric hospital in the Western Cape</strong></p><p>P Milligan, J S Parker</p><p><strong>33. Durban youth healh-sk behaviour: Prevalence f Violence-related behaviour</strong></p><p>D L Mkize</p><p><strong>34. Profile of morality of patients amitted Weskoppies Psychiatric Hospital in Sout frican over a 5-Year period (2001-2005)</strong></p><p>N M Moola, N Khamker, J L Roos, P Rheeder</p><p><strong>35. One flew over Psychiatry nest</strong></p><p>Leverne Mountany</p><p><strong>36. The ethical relationship betwe psychiatrists and the pharmaceutical indutry</strong></p><p>Margaret G Nair</p><p><strong>37. Developing the frameor of a postgraduate da programme in mental health</strong></p><p>R J Nichol, B de Klerk, M M Nel, G van Zyl, J Hay</p><p><strong>38. An unfolding story: The experience with HIV-ve patients at a Psychiatric Hospital</strong></p><p>J S Parker, P Milligan</p><p><strong>39. Task shifting: A practical strategy for scalingup mental health care in developing countries</strong></p><p>Vikram Patel</p><p><strong>40. Ethics: Informed consent and competency in the elderly</strong></p><p>Willie Pienaar</p><p><strong>41. Confronting ommonmoral dilemmas. Celebrating uncertainty, while in search patient good</strong></p><p>Willie Pienaar</p><p><strong>42. Moral dilemmas in the treatment and repatriation of patients with psychtorders while visiting our country</strong></p><p>Duncan Ian Rodseth</p><p><strong>43. Geriatrics workshop (Psegal symposium): Medico-legal issuess in geriatric psyhiatry</strong></p><p>Felix Potocnik</p><p><strong>44. Brain stimulation techniques - update on recent research</strong></p><p>P J Pretorius</p><p><strong>45. Holistic/Alternative treatments in psychiatry</strong></p><p>T Rangaka, J Dill</p><p><strong>46. Cognitive behaviour therapy and other brief interventions for management of substances</strong></p><p>Solomon Rataemane</p><p><strong>47. A Transtheoretical view of change</strong></p><p>Nathan P Rogerson</p><p><strong>48. Profile of security breaches in longerm mental health care users at Weskoppies Hospital over a 6-month period</strong></p><p>Deleyn Rema, Lindiwe Mthethwa, Christa Kruger</p><p><strong>49. Management of psychogenic and chronic pain - A novel approach</strong></p><p>M S Salduker</p><p><strong>50. Childhood ADHD and bipolar mood disorders: Differences and similarities</strong></p><p>L Scribante</p><p><strong>51. The choice of antipsychotic in HIV-infected patients and psychopharmacocal responses to antipsychotic medication</strong></p><p>Dinesh Singh, Karl Goodkin</p><p><strong>52. Pearls in clinical neuroscience: A teaching column in CNS Spectrums</strong></p><p><strong></strong>Dan J Stein</p><p><strong>53. Urinary Cortisol secretion and traumatics in a cohort of SA Metro policemen A longitudinal study</strong></p><p>Ugash Subramaney</p><p><strong>54. Canabis use in Psychiatric inpatients</strong></p><p><strong></strong>M Talatala, G M Nair, D L Mkize</p><p><strong>55. Pathways to care and treatmt in first and multi-episodepsychosis: Findings fm a developing country</strong></p><p>H S Teh, P P Oosthuizen</p><p><strong>56. Mental disorders in HIV-infected indivat various HIV Treatment sites in South Africa</strong></p><p>Rita Thom</p><p><strong>57. Attendanc ile of long-term mental health care users at ocupational therapy group sessions at Weskoppies Hospital</strong></p><p>Ronel van der Westhuizen, Christa Kruger</p><p><strong>58. Epidemiological patterns of extra-medical drug use in South Africa: Results from the South African stress and health study</strong></p><p>Margaretha S van Heerden, Anna Grimsrud, David Williams, Dan Stein</p><p><strong>59. 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Since the 1970's, global efforts have been going on to replace the high-enriched (>90% 235U), low-density UAlx research reactor fuel with high-density, low enriched (<20% 235U) replacements. This search is driven by the attempt to reduce the civil use of high-enriched material because of proliferation risks and terrorist threats. American initiatives, such as the Global Threat Reduction Initiative (GTRI) and the Reduced Enrichment for Research and Test Reactors (RERTR) program have triggered the development of reliable low-enriched fuel types for these reactors, which can replace the high enriched ones without loss of performance. Most success has presently been obtained with U3Si2 dispersion fuel, which is currently used in many research reactors in the world. However, efforts to search for a replacement with even higher density, which will also allow the conversion of some high flux research reactors that currently cannot change to U3Si2 (eg. BR2 in Belgium), have continued and are for the moment mainly directed towards the U(Mo) alloy fuel (7-10 w% Mo). This paper provides an overview of the past efforts and presents the current status of the U(Mo) development.

B a c k g r o u n d . The relevance and purpose of the research. Institutions of higher education (HEIs) are mostly city-forming objects, and the design of the surrounding territory affects their image, the aestheticization of the environment, and performs a decorative function. Today's challenges require the improvement of landscapes and architecture of higher education institutions, and this problem is urgent, because universities gather a large number of young people from different regions and countries of the world, who have to live and study in appropriate comfortable conditions. Mostly, the problem of organizing the territory is considered from the point of view of greening, rather than a comprehensive landscape project. Therefore, the formation of a holistic space of the university campus, taking into account modern scientific approaches to the design of landscape architecture objects in the conditions of global climate change, seems to be extremely relevant. The goal is to conduct an analysis of the features of the organization of the green zone of the Taras Shevchenko Kyiv National University campus (Exhibition Center campus) taking into account the requirements that are put forward to the higher educational institution. Research materials and methods. The object of research was the territory of the Taras Shevchenko Kyiv National University campus (Exhibition Center campus). M e t h o d s . Methods of searching for information in printed and electronic publications, searchable scientific databases, as well as methods of data analysis, comparison and generalization, field surveys, measurements on geodetic maps using the AutoCADin vector format. R e s u l t s . The standards for greening the territory of the ZVO were analyzed. The state of green spaces of higher educational institutions depends on the selection of plants adapted to climatic and soil conditions, as well as recreational loads. Most Ukrainian institutions of higher education do not meet the standards of "green universities". The functional zoning of the KNU campus (Exhibition Center) complies with building regulations, but the green area on the territory is distributed unevenly. It is necessary to pay attention to the use of phytoorganic background of green park plantings as an option of aerofitotherapy, taking into account modern data on the positive effect of biogenic volatile organic substances on the human body. C o n c l u s i o n s . The green zone is an integral element of the structure of educational campuses, when developing each of the design options for the solution of the territory, it is necessary to offer a new image that corresponds to modern trends in design and will make it possible to create a functionally sufficient and unique environment.

A microwave digestion procedure was developed for multi-element determinations in tree foliage by inductively coupled plasma–atomic emission spectrometry. The procedure involved the sequential digestion of 0.500 g of plant material with HNO3 (10 mL), H2O2 (1 mL), and HCl (2 mL) at 90% power for 30 min, 90% power for 15 min, and 30% power for 10 min, respectively. The proposed method gave Ca, Mg, K, Na, Mn, P, and S results in good agreement with the National Institute of Standards and Technology plant reference materials. Iron and aluminum concentrations were 20 to 30% lower than the certified National Institute of Standards and Technology values. Recovery of standard additions of the elements tested (including iron and aluminum) ranged from 93 to 105%. The proposed digestion method provides accurate and precise results for multi-element analysis on one solution. In addition, HClO4, an extreme laboratory hazard, has been replaced in the digestion procedure by H2O2. The microwave digestion method has been used successfully in our laboratory for over 1 year for routine analysis and for a quality assurance program using a variety of plant materials. With this method 36 to 48 samples per person per day can be prepared for inductively coupled plasma–atomic emission spectrometry analysis.

This paper is primarily concerned with the accessibility of airports located in small and geographically isolated communities. Specifically, it carries out a sensitivity analysis to derive rates of change for the parameters of a spatial interaction model applied to empirical air passenger trip data, and interprets the results focusing on the local airports subsidized by the Essential Air Service program. An empirical trip based accessibility measure is developed for individual airports in the contiguous US air transportation system. The measure enables us to capture the distinctive roles of small airports, which primarily function as regional associates of nearby cities and entrances for long-haul trips via major hub(s) to continental-scale connections. We observe the geographic and temporal variability of accessibility among airports, regarding the external factors including the dynamics of air carriers’ routing schemes, as well as global and local circumstances. Their impacts on passenger journey lengths are substantial at the local airports due to the few available connections. This issue has received less attention in existing subsidy program assessments. Furthermore, we explore the geographic distribution of non-subsidized local airports showing similar accessibility conditions. This paper enhances prior development by showing that the rates of change in accessibility scores are largely stable over recent national air passenger data.

Religious tolerance is a supporter of social harmony and brings a country to a better life. Instilling tolerance in early childhood is a challenge for early childhood educators. This study aims to describe the transformation of religious tolerance values ​​by teachers in early childhood education. This research is a type of qualitative case study research model with researchers as observer participants. This research produces the following findings, that (1) transformation of tolerance values ​​among religious communities, is explicitly not taught in Early Childhood Education (ECE) on the grounds that all students are of the same religion, (2) transformation of tolerance of values among religious students taught through learning integrated with other lessons, (3) although explicitly the values ​​of tolerance among religious students are not taught, but the values ​​of togetherness such as greeting, sharing something that is owned, and helping the needs of other students are taught by practicing at the same time. Keywords: Early Childhood Education, Tolerance Values in Religion References: Adams, K. (2019). Navigating the spaces of children’s spiritual experiences: influences of tradition(s), multidisciplinarity and perceptions. International Journal of Children’s Spirituality, 24(1), 29–43. https://doi.org/10.1080/1364436X.2019.1619531 Adams, K., Bull, R., & Maynes, M. L. (2016). Early childhood spirituality in education: Towards an understanding of the distinctive features of young children’s spirituality. European Early Childhood Education Research Journal, 24(5), 760–774. https://doi.org/10.1080/1350293X.2014.996425 Atamturk, N. (2018). The role of English as a foreign language classes in tolerance education in relation to school management practices. Quality and Quantity, 52, 1167–1177. https://doi.org/10.1007/s11135-017-0575-7 Banerjee, K., & Bloom, P. (2015). “Everything Happens for a Reason”: Children’s Beliefs About Purpose in Life Events. Child Development, 86(2), 503–518. https://doi.org/10.1111/cdev.12312 Bano, M., & Ferra, E. (2018). Family versus school effect on individual religiosity: Evidence from Pakistan. International Journal of Educational Development, 59(August 2017), 35–42. https://doi.org/10.1016/j.ijedudev.2017.10.015 Coleman, E. B., & Eds, K. W. (2011). Religious Tolerance, Education and the Curriculum. 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Introduction. Bronchial hyperresponsiveness (BHR) is a factor in predicting bronchial asthma independently of inflammation markers. Objective. The aims were to determine the frequency and important predictive facts of BHR and the effect of prophylaxis by Global Initiative for Asthma (GINA) and National Asthma Education and Prevention Program (NAEPP) on BHR in asthmatic children. Methods. BHR in 106 children was evaluated by the bronchoprovocation test with methacholine. Results. The prevalence rate of symptomatic BHR is 18% for crucial point of PC20=4.1?3.03 mg/ml and PD20=3.22?2.59 ?mol methacholine. On average asthmatic children express moderate BHR, which persists even two years after administering prophylaxis. After two years bronchial reactivity is significantly smaller, the change of FEV1 is significantly smaller, the velocity of change of slope dose response curve (sDRC) is faster and the provocative concentration of methacholine that causes wheezing is 2-3 times lower. A mild sDRC shows milder bronchoconstriction after two years. The fast change of bronchial reactivity in 41% of asthmatic children is contributed to aero-pollution with sulfur dioxide and/ or, possible insufficient and/or inadequate treatment during two years of administering prophylaxis. A simultaneous effect of allergens from home environment and grass and tree pollens and of excessive aero-pollution on children?s airways is important in the onset of symptomatic BHR. After two years of treatment by GINA and NAEPP children do not show asthma symptoms or show mild asthma symptoms, however bronchial sensitivity remains unchanged. Conclusion. Optimal duration of anti-inflammatory treatment in asthmatic children who show moderate bronchial hyperresponsiveness should be longer than two years.

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AbstractAt beginning of the 1980‘s, the National Science Foundation (USA) came up with the initiation of the program for Long-Term Ecological Research (LTER), which is a program based on long-term comprehensive study of the structure and processes of ecosystems. The Ecological Experimental Station (EES) in the Kremnické vrchy Mountains (Western Carpathians, Slovakia, 1986) was founded for similar purposes. The aim of the research at EES was to evaluate the productivity, carrying capacity and functioning of the beech ecosystem. In February 1989, five plots were established. Four plots were subjected to a regeneration cutting of different intensities (clear-cut, strip shelterwood cut: light, medium and heavy). The fifth plot was left without any management treatments as a control. The second cutting was performed in 2004 followed by the final cutting five years later. Currently, the research is carried out on the EES control plot in the stand comprising 115–120 years old beech trees. In the other stands the research is focused on the development of naturally regenerated beech ecosystems established after different cutting interventions. The future of the EES is in addressing some global issues, particularly the impact of climate change on primary production, as well as on its other consequences for the functioning of the affected ecosystems.

We report on contaminants identified in nestling bald eagles of Grant Teton National Park (GTNP) and the Snake River Unit (SRU), Wyoming, during summers of 2006 and 2007. We focus primarily on mercury (Hg), lead (Pb), and selenium (Se) because each was detected in all nestlings during both summers at moderate levels. Independent t-tests were performed both on the raw data and log­transformed data (using the natural logarithm) as a comparative analysis to investigate if contaminant loads had significantly increased from summer 2006 to summer 2007. Also, as a comparative analysis and alternative procedure, nest site was treated as the experimental unit and a repeated-measures analysis (longitudinal study) was conducted on the raw data to investigate if contaminant loads had significantly increased from summer 2006 to summer 2007. Results of the analysis indicate that levels of Se essentially remained unchanged from summer 2006 to summer 2007 (p=0.466, log-transformed data). Levels of Pb in nestlings increased from summer 2006 to summer 2007 (p=0.000, log-transformed data). There was no difference in levels of Hg in nestlings from summer 2006 to summer 2007 (p=0.058, log-transformed data). The molar ratio (2.54ppm Se: 1 ppm Hg) of Se to Hg did not change from 2006 to 2007 (p=0.337, raw data), although a 45% decrease in molar ratio was observed. Analyses of contaminants (using geometric means) in the blood of nestlings (from summer 2006 to 2007) showed a 64% increase in Hg, a five-fold increase in Pb ( 481% ), and a 21% increase in Se. Potential localized sources of Pb contamination should be identified and removed from the proximity of any nest site(s) and the study area in general. Advancing global climate change and associated desiccation and emolation of temperate and boreal forests, exacerbated by extensive clear-cutting may increase poisoning of aquatic ecosystems with high levels of contaminants, especially Hg, in the future. A monitoring program may be indicated to identify potential long-term changes within the GYE. (p=O.OOO, log-transformed data). There was no difference in levels of Hg in nestlings from summer 2006 to summer 2007 (p=0.058, log­ transformed data). The molar ratio (2.54ppm Se: 1ppm Hg) of Se to Hg did not change from 2006 to 2007 (p=0.337, raw data), although a 45% decrease in molar ratio was observed. Analyses of contaminants (using geometric means) in the blood of nestlings (from summer 2006 to 2007) showed a 64% increase in Hg, a five-fold increase in Pb (481%), and a 21 % increase in Se. Potential localized sources of Pb contamination should be identified and removed from the proximity of any nest site(s) and the study area in general.

Global climate change is expected to impact future precipitation and surface temperature trends and could alter local hydrologic systems. This study assessed the likely hydrologic responses and changes in streamflow due to future climate change within the Alabama River Basin (ARB) for the mid-21st century 2045 (“2030–2060”) and end-21st century 2075 (“2060–2090”). Using an integrated modeling approach, General Circulation Model (GCM) datasets; the Centre National de Recherches Météorologiques Climate Model 5 (CNRM-CM5), the Community Earth System Model, version 1–Biogeochemistry (CESM1- BGC.1), and the Hadley Centre Global Environment Model version 2 (HADGEM2-AO.1), under medium Representative Concentration Pathway (RCP) 4.5, and based on World Climate Research Program (WCRP)’s Couple Model Intercomparison Phase 5 (CMIP5), were assimilated into calibrated Soil and Water Assessment Tool (SWAT). Mann–Kendall and Theil Sen’s slope were used to assess the trends and magnitude of variability of the historical climate data used for setting up the model. The model calibration showed goodness of fit with minimum Nash–Sutcliffe Efficiency (NSE) coefficient values of 0.83 and Coefficient of Determination (R2) of 0.88 for the three gages within the ARB. Next, the research assessed changes in streamflow for the years 2045 and 2075 against that of the reference baseline year of 1980. The results indicate situations of likely increase and decrease in mean monthly streamflow discharge and increase in the frequency and variability in peak flows during the periods from the mid to end of the 21st century. Seasonally, monthly streamflow increases between 50% and 250% were found for spring and autumn months with decreases in summer months for 2045. Spring and summer months for 2075 resulted in increased monthly streamflow between 50% and 300%, while autumn and spring months experienced decreased streamflow. While the results are prone to inherent uncertainties in the downscaled GCM data used, the simulated dynamics in streamflow and water availability provide critical information for stakeholders to develop sustainable water management and climate change adaptation options for the ARB.

Abstract Background Antibiotic stewardship program (ASP) implementation is paramount across the healthcare spectrum. Nursing homes represent a challenge due to limited resources, complexity of medical conditions, and less controlled environments. National statistics on ASP for long-term care facilities (LTCF) are sparse. Methods A pilot ASP was launched in August 2016 at a 270-bed nursing home with a 50-bed chronic ventilator-dependent unit. The program entailed a bundle of interventions including leadership engagement, a tracking and reporting system for intravenous antibiotics, education for caregivers, Infectious Disease (ID) consultant availability, and implementation of nursing protocols. Data were collected from pharmacy and medical records between January 2016 and March 2017, establishing pre-intervention and post-intervention periods. Collected data included days of therapy (DOT), antibiotic costs, resident-days, hospital transfers, and Clostridium difficile infection (CDI) rates. Variables were adjusted to 1,000 resident-days (RD) and findings between periods were compared by Mann–Whitney U test. Results A total of 47,423 resident-days and 1,959 DOT were analyzed for this study. Antibiotic use decreased from 54.5 DOT/1000 RD pre-intervention to 27.6 DOT/1000 RD post-intervention (P = 0.017). Antibiotic costs were reduced from a monthly median of US $17,113 to US $7,073 but was not statistically significant (P = 0.39). Analysis stratified by individual antibiotic was done for the five most commonly used antibiotics and found statistically significant reduction in vancomycin use (14.4 vs. 6.5; P = 0.023). Reduction was also found for cefepime/ceftazidime (6.9 vs. 1.3; P = 0.07), ertapenem (6.8 vs. 3.6; P = 0.45), and piperacillin/tazobactam (1.8 vs. 0.6; P = 0.38). Meropenem use increased (1.3 vs. 3.2; P = 0.042). Hospital transfers slightly trended up (6.73 vs. 7.77; P = 0.065), and there was no change in CDI (1.1 s 0.94; P = 0.32). Conclusion A bundle of standardized interventions tailored for LTCF can achieve successful reduction of antibiotic utilization and costs. Subsequent studies are needed to further determine the impact on clinical outcomes such as transfers to hospitals and CDI in these settings. Disclosures All authors: No reported disclosures.

Ferroelectric field-effect transistors (FEFETs) are receiving significant attention from the microelectronics community for next-generation memory technologies, especially as embedded non-volatile elements for data-centric applications. The main attractive features of FEFETs are that write energy and speed of FEFETs are within an order of magnitude of respective metrics for SRAMs (FEFET ~1 fJ and 1-10 ns vs. SRAM: <1 fJ and <1 ns), all the while requiring a significantly smaller cell size (FEFET 50-60F2 vs. SRAM 120-150F2) and close-to-zero standby leakage power – provided that FEFETs are integrated at the same advanced technology nodes as SRAMs [1]. In this talk, we will discuss the potential path for FEFET toward fulfilling this vision, by addressing the outstanding technological challenges: ultra-fast read-after write, reliability, voltage scaling and variation. To that end, our recent exposition on the trap and reliability physics of FEFETs will highlighted. We will highlight, based on newly developed experimental schemes, how the simultaneous capture and emission of electrons and holes in write cycles occur at the interface and the grain boundaries in the time domain, where in the band-diagram, these traps (acceptors and donors) are located and how exactly they result in the degradation of the read speed and reliability with continued write cycling. Based on these insights, we move on show how engineering the interfacial layer and the ferroelectric grain structure can enable ultra-fast read-after write and write voltage and dramatic improvements in reliability and variation, towards achieving a high-density, ultra-high speed memory technology. This research is supported by the National Science Foundation, the Defense Advanced Research Program Agency (DARPA), the Semiconductor Research Corporation (SRC) - Global Research Collaboration (GRC) program, the Applications and Systems-Driven Center for Energy-Efficient Integrated Nano Technologies (ASCENT), one of six centers in the Joint University Microelectronics Program (JUMP), a SRC program sponsored by the DARPA, and an Intel Rising Star award. [1] Mikolajick, T., Schroeder, U. & Slesazeck, S. The past, the present, and the future of ferroelectric memories. IEEE Trans. Electron Devices 67, 1434–1443 (2020). [2] Asif Islam Khan, Ali Keshavarzi, and Suman Datta. “The future of ferroelectric field-effect transistor technology." Nature Electronics 3.10 (2020): 588-597.

Climate change and sustainability science have become more international in scope and transdisciplinary in nature, in response to growing expectations that scientific knowledge directly informs collective action and transformation. In this article, we move past idealized models of the science–policy interface to examine the social processes and geopolitical dynamics of knowledge mobilization. We argue that sociotechnical imaginaries of transdisciplinary research, deployed in parallel to “universal” regimes of evidence-based decision-making from the global North, conceal how international collaborations of scientists and societal actors actually experience knowledge mobilization, its systemic barriers, and its paths to policy action. Through ethnographic study of a transdisciplinary research program in the Americas, coupled with in-depth analysis of Colombia, we reveal divergences in how participants envision and experience knowledge mobilization and identify persistent disparities that diminish the capacity of researchers to influence decision-making and fit climate knowledge within broader neoliberal development paradigms. Results of the study point to a plurality of science–policy interface(s), each shaped by national sociotechnical imaginaries, development priorities, and local social orders. We conclude that a geopolitical approach to transdisciplinary science is necessary to understand how climate and sustainability knowledge circulates unevenly in a world marked by persistent inequality and dominance.

The critical roles of the Higher Education Institutions (HEI) towards the achievement of sustainable development signifies the need to implement Education for Sustainable Development (ESD). Opportunities in applying ESD can be accomplished in different dimensions of the school to pursue the worldwide acceptance of the Sustainable Development Goals (SDGs). This formed a question for San Beda University (SBU) to describe its practices and programs towards the achievement of ESD. In this study, the community extension and citizenship education of San Beda University were specifically examined in its Community Engagement Center (CEC) and National Service Training Program (NSTP). The study employed a framework on the Priority Sustainable Development Goals (SDGs) of SBU and selected key features and strategies of ESD. After a critical assessment of the procedures, teaching methods, documents, and interviews, the results of the study identified the practices and programs including specific teaching activities. The results illustrate the level by which SBU utilizes SDGs towards sustainability. The conclusion provided recommendations to encourage increasing the commitment of SBU in integrating SDGs in instruction, research, and extension. The study is significant in providing a preliminary assessment of the level of SBU engagement towards SDGs. It demonstrated the actions of how a university implements sustainable development. The study intends to contribute to the continuous implementation of ESD and improve the SDG performance of SBU as institutional change agent.ReferencesAlbareda-Tiana, S., Vidal-Raméntol, S., and Fernández-Morilla, M. (2018). Implementing the sustainable development goals at university level. International Journal of Sustainability in Higher Education. 19(3), 473-497. https://doi.org/10.1108/IJSHE-05-2017-0069Balanay, R.M. & Halog, A. (2016). Teaching education for sustainable development at university level: A case study from the Philippines. Teaching Education for Sustainable Development at University Level. World Sustainability Series. 1, 163-174, https://doi.org/10.1007/978-3-319-32928-4_11Community Engagement Center (CEC) – SBU. (2016). Institute of Community Involvement Center Manual of Operations. Unpublished manuscript. San Beda University, Manila.Dela Serna, A. (2018). Teaching sustainable development in the Philippines: Looking through the lens of education for sustainable development (esd). ASEAN Conference on Education. p. 841 – 851. http://www.pbic.tu.ac.th/wp-content/uploads/2019/10/2018-Aceproceedings.pdfKates, R., Parris, T., and Leiserowitz, A. (2005). What Is Sustainable Development? 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Journal of Cleaner Production. 232, 285-294. https://doi.org/10.1016/j.jclepro.2019.05.309.National Economic and Development Authority. (2019). The 2019 voluntary national review of the Philippines. https://sustainabledevelopment.un.org/content/documents/23366Voluntary_National_Review_2019_Philippines.pdfSan Beda University. (2014). College of Arts and Sciences Course catalogue 2014 – 2015. Unpublished manuscript.San Beda University. (2019). College of Arts and Science Course syllabus 2019 – 2020: National service training program-civic welfare training services I. Unpublished manuscript.Sustainable Development Solutions Network (SDSN). (2015). Indicators and a monitoring framework for the sustainable development goals. Launching a data revolution. https://irp-cdn.multiscreensite.com/be6d1d56/files/uploaded/150612-FINAL-SDSN-Indicator-Report-Executive-Summary.pdfSustainable Development Solutions Network (SDSN). (2017). 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The contemporary Balkans are still an area of unfinished peace. Its pacification and development depend on a faster process of regionalization and globalization, but also on changing the transition strategy and opening up to the elites of knowledge as actors in the economic, social, and cultural development of the countries of this region. Current flows in the European integration process are predominantly dictated by geostrategic interests but not by development goals. The paper discusses the actors of cross-border cooperation in the Balkans, with special reference to the role of the knowledge elite and the new diaspora in regional development and the affirmation of the culture of peace in this fragile geopolitical space. The focus is on the problematization of the thesis on the role of the new intellectual diaspora from the Balkans, which is an integral part of the global transnational actors of social changes in modern times and whose cognitive, innovative, and social capital, through the process of return mobility (circular migrations of knowledge elites), can contribute to faster local, national, and regional development. The attachment indicates the high creative-innovative potential of the new Balkan diaspora, embodied in the elites of knowledge, innovators, managers, and entrepreneurs in the world, which can be included in the partnership program for local, national, and regional development with the new wise policy of nomenclature in the region. This requires the redefinition of the ruling strategy of dependent modernization and comprador development management and the establishment of a new autonomous policy of social development based on local wisdom ("ours and the world's"), intensive intra-regional connection and integration, and the reactualization of the value of the slogan "Balkans, Balkan peoples!" Sociological research conducted in the last twenty years shows the slowness of cross-border cooperation processes in the region, the still high degree of exchange with countries outside the region, and the fact that the identity perception of the student population is focused on national or European values while regional values are neglected. It is time to change these priorities in identification, which will be connected with real processes of cross-border cooperation and the strengthening of understanding and a culture of peace in the Balkans.

Through a careful analysis of official government documents such as national statutes, national agency memorandum orders, policy directives reports, and national and local plans, among others, pertinent to the Philippine Government's response to climate change mitigation and adaptation, the paper elucidated the policy directions of the country concerning climate change response. Aimed at proposing recommendations to enhance the current legal, organizational, and fiscal frameworks of the Philippine Government in its efforts to mainstream its climate change strategy, the paper identified some of the gaps and possible areas of improvement in the standing legal and structural constellations of policies employed in the country. It has been found by the research that though there have been actions related to the international mandate of promoting sustainable development, there are still areas that can be reformed and revisited if the government programs and institutions are to remain in fidelity to the commitments of the Philippines to combat the impacts and mitigate the effects of climate change. As the title suggests, the paper offers policy directions to strengthen government and academic institutions to better respond to this daunting challenge.References2013 Typhoon Haiyan: Facts, FAQs, and how to help. (n.d.). World vision. https://www.worldvision.org/disaster-relief-news-stories/2013-typhoon-haiyan-facts.Asian Disaster Reduction Center. (n.d.). Information on disaster risk reduction of member countries. https://www.adrc.asia/nationinformation.php?NationCode=608&Lang=en.Asian Development Bank. (2012). Addressing migration and climate change in Asia and the Pacific: Final report. ADB.Blair, H. (2000). 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Hamsters were exposed to sodium arsenite (173 mg As/L) in drinking water for 6 days. Equal amounts of proteins from urinary bladder or liver extracts of control and arsenic-treated hamsters were labeled with Cy3 and Cy5 dyes, respectively. After differential in gel electrophoresis and analysis by the DeCyder software, several protein spots were found to be down-regulated and several were up regulated. Our experiments indicated that in the bladder tissues of hamsters exposed to arsenite, transgelin was down-regulated and GST-pi was up-regulated. The loss of transgelin expression has been reported to be an important early event in tumor progression and a diagnostic marker for cancer development [29-32]. Down-regulation of transgelin expression may be associated with the carcinogenicity of inorganic arsenic in the urinary bladder. In the liver of arsenite-treated hamsters, ornithine aminotransferase was up-regulated, and senescence marker protein 30 and fatty acid binding protein were down-regulated. The volume ratio changes of these proteins in the bladder and liver of hamsters exposed to arsenite were significantly different than that of control hamsters. Introduction Chronic exposure to inorganic arsenic can cause cancer of the skin, lungs, urinary bladder, kidneys, and liver [1-6]. The molecular mechanisms of the carcinogenicity and toxicity of inorganic arsenic are not well understood [7-9). Humans chronically exposed to inorganic arsenic excrete MMA(V), DMA(V) and the more toxic +3 oxidation state arsenic biotransformants MMA(III) and DMA (III) in their urine [10, 11], which are carcinogen [12]· After injection of mice with sodium arsenate, the highest concentrations of the very toxic MMA(III) and DMA(III) were in the kidneys and urinary bladder tissue, respectively, as shown by experiments of Chowdhury et al [13]. Many mechanisms of arsenic toxicity and carcinogenicity have been suggested [1, 7, 14] including chromosome abnormalities [15], oxidative stress [16, 17], altered growth factors [18], cell proliferation [19], altered DNA repair [20], altered DNA methylation patterns [21], inhibition of several key enzymes [22], gene amplification [23] etc. Some of these mechanisms result in alterations in protein expression. Methods for analyzing multiple proteins have advanced greatly in the last several years. In particularly, mass spectrometry (MS) and tandem MS (MS/MS) are used to analyze peptides following protein isolation using two-dimensional (2-D) gel electrophoresis and proteolytic digestion [24]. In the present study, Differential In Gel Electrophoresis (DIGE) coupled with Mass Spectrometry (MS) has been used to study some of the proteomic changes in the urinary bladder and liver of hamsters exposed to sodium arsenite in their drinking water. Our results indicated that transgelin was down-regulated and GST-pi was up-regulated in the bladder tissues. In the liver tissues ornithine aminotransferase was up-regulated, and senescence marker protein 30, and fatty acid binding protein were down-regulated. Materials and Methods Chemicals Tris, Urea, IPG strips, IPG buffer, CHAPS, Dry Strip Cover Fluid, Bind Silane, lodoacetamide, Cy3 and Cy5 were from GE Healthcare (formally known as Amersham Biosciences, Uppsala, Sweden). Thiourea, glycerol, SDS, DTT, and APS were from Sigma-Aldrich (St. Louis, MO, USA). Glycine was from USB (Cleveland, OH, USA). Acrylamide Bis 40% was from Bio-Rad (Hercules, CA, USA). All other chemicals and biochemicals used were of analytical grade. All solutions were made with Milli-Q water. Animals Male hamsters (Golden Syrian), 4 weeks of age, were purchased from Harlan Sprague Dawley, USA. Upon arrival, hamsters were acclimated in the University of Arizona animal care facility for at least 1 week and maintained in an environmentally controlled animal facility operating on a 12-h dark/12-h light cycle and at 22-24°C. They were provided with Teklad (Indianapolis, IN) 4% Mouse/Rat Diet # 7001 and water, ad libitum, throughout the acclimation and experimentation periods. Sample preparation and labelling Hamsters were exposed to sodium arsenite (173 mg) in drinking water for 6 days and the control hamsters were given tap water. On the 6th day hamsters were decapitated rapidly by guillotine. Urinary bladder tissues and liver were removed, blotted on tissue papers (Kimtech Science, Precision Wipes), and weighed. Hamster urinary bladder or liver tissues were homogenized in lysis buffer (30mMTris, 2M thiourea, 7M urea, and 4% w/w CHAPS adjusted to pH 8.5 with dilute HCI), at 4°C using a glass homogenizer and a Teflon coated steel pestle; transferred to a 5 ml acid-washed polypropylene tube, placed on ice and sonicated 3 times for 15 seconds. The sonicate was centrifuged at 12,000 rpm for 10 minutes at 4°C. Small aliquots of the supernatants were stored at -80°C until use (generally within one week). Protein concentration was determined by the method of Bradford [25] using bovine serum albumin as a standard. Fifty micrograms of lysate protein was labeled with 400 pmol of Cy3 Dye (for control homogenate sample) and Cy5 Dye (for arsenic-treated urinary bladder or liver homogenate sample). The samples containing proteins and dyes were incubated for 30 min on ice in the dark. To stop the labeling reaction, 1uL of 10 mM lysine was added followed by incubation for 10 min on ice in the dark. To each of the appropriate dye-labeled protein samples, an additional 200 ug of urinary bladderor liver unlabeled protein from control hamster sample or arsenic-treated hamster sample was added to the appropriate sample. Differentially labeled samples were combined into a single Microfuge tube (total protein 500 ug); protein was mixed with an equal volume of 2x sample buffer [2M thiourea, 7M urea, pH 3-10 pharmalyte for isoelectric focusing 2% (v/v), DTT 2% (w/v), CHAPS 4% (w/v)]; and was incubated on ice in the dark for 10 min. The combined samples containing 500 ug of total protein were mixed with rehydration buffer [CHAPS 4% (w/v), 8M urea, 13mM DTT, IPG buffer (3-10) 1% (v/v) and trace amount of bromophenol blue]. The 450 ul sample containing rehydration buffer was slowly pipetted into the slot of the ImmobilinedryStripReswelling Tray and any large bubbles were removed. The IPG strip (linear pH 3-10, 24 cm) was placed (gel side down) into the slot, covered with drystrip cover fluid (Fig. 1), and the lid of the Reswelling Tray was closed. The ImmobillineDryStrip was allowed to rehydrate at room temperature for 24 hours. First dimension Isoelectric focusing (IEF) The labeled sample was loaded using the cup loading method on universal strip holder. IEF was then carried out on EttanIPGphor II using multistep protocol (6 hr @ 500 V, 6 hr @ 1000 V, 8 hr @ 8000 V). The focused IPG strip was equilibrated in two steps (reduction and alkylation) by equilibrating the strip for 10 min first in 10 ml of 50mM Tris (pH 8.8), 6M urea, 30% (v/v) glycerol, 2% (w/v) SDS, and 0.5% (w/v) DTT, followed by another 10 min in 10 ml of 50mM Tris (pH 8.8), 6M urea, 30% (v/v) glycerol, 2% (w/v) SDS, and 4.5% (w/v) iodoacetamide to prepare it for the second dimension electrophoresis. Second dimension SDS-PAGE The equilibrated IPG strip was used for protein separation by 2D-gel electrophoresis (DIGE). The strip was sealed at the top of the acrylamide gel for the second dimension (vertical) (12.5% polyacrylamide gel, 20x25 cm x 1.5 mm) with 0.5% (w/v) agarose in SDS running buffer [25 mMTris, 192 mM Glycine, and 0.1% (w/v) SDS]. Electrophoresis was performed in an Ettan DALT six electrophoresis unit (Amersham Biosciences) at 1.5 watts per gel, until the tracking dye reached the anodic end of the gel. Image analysis and post-staining The gel then was imaged directly between glass plates on the Typhoon 9410 variable mode imager (Sunnyvale, CA, USA) using optimal excitation/emission wavelength for each DIGE fluor: Cy3 (532/580 nm) and Cy5 (633/670 nm). The DIGE images were previewed and checked with Image Quant software (GE Healthcare) where all the two separate gel images could be viewed as a single gel image. DeCyde v.5.02 was used to analyze the DIGE images as described in the Ettan DIGE User Manual (GE Healthcare). The appropriate up-/down regulated spots were filtered based on an average volume ratio of ± over 1.2 fold. After image acquisition, the gel was fixed overnight in a solution containing 40% ethanol and 10% acetic acid. The fixed gel was stained with SyproRuby (BioRad) according to the manufacturer protocol (Bio-Rad Labs., 2000 Alfred Nobel Drive, Hercules, CA 94547). Identification of proteins by MS Protein spot picking and digestion Sypro Ruby stained gels were imaged using an Investigator ProPic and HT Analyzer software, both from Genomic Solutions (Ann Arbor, MI). Protein spots of interest that matched those imaged using the DIGE Cy3/Cy5 labels were picked robotically, digested using trypsin as described previously [24] and saved for mass spectrometry identification. Liquid chromatography (LC)- MS/MS analysis LC-MS/MS analyses were carried out using a 3D quadrupole ion trap massspectrometer (ThermoFinnigan LCQ DECA XP PLUS; ThermoFinnigan, San Jose, CA) equipped with a Michrom Paradigm MS4 HPLC (MichromBiosources, Auburn, CA) and a nanospray source, or with a linear quadrupole ion trap mass spectrometer (ThermoFinnigan LTQ), also equipped with a Michrom MS4 HPLC and a nanospray source. Peptides were eluted from a 15 cm pulled tip capillary column (100 um I.D. x 360 um O.D.; 3-5 um tip opening) packed with 7 cm Vydac C18 (Vydac, Hesperia, CA) material (5 µm, 300 Å pore size), using a gradient of 0-65% solvent B (98% methanol/2% water/0.5% formic acid/0.01% triflouroacetic acid) over a 60 min period at a flow rate of 350 nL/min. The ESI positive mode spray voltage was set at 1.6 kV, and the capillary temperature was set at 200°C. Dependent data scanning was performed by the Xcalibur v 1.3 software on the LCQ DECA XP+ or v 1.4 on the LTQ [27], with a default charge of 2, an isolation width of 1.5 amu, an activation amplitude of 35%, activation time of 50 msec, and a minimal signal of 10,000 ion counts (100 ion counts on the LTQ). Global dependent data settings were as follows: reject mass width of 1.5 amu, dynamic exclusion enabled, exclusion mass width of 1.5 amu, repeat count of 1, repeat duration of a min, and exclusion duration of 5 min. Scan event series were included one full scan with mass range of 350-2000 Da, followed by 3 dependent MS/MS scans of the most intense ion. Database searching Tandem MS spectra of peptides were analyzed with Turbo SEQUEST, version 3.1 (ThermoFinnigan), a program that allows the correlation of experimental tandem MS data with theoretical spectra generated from known protein sequences. All spectra were searched against the latest version of the non redundant protein database from the National Center for Biotechnology Information (NCBI 2006; at that time, the database contained 3,783,042 entries). Statistical analysis The means and standard error were calculated. The Student's t-test was used to analyze the significance of the difference between the control and arsenite exposed hamsters. P values less than 0.05 were considered significant. The reproducibility was confirmed in separate experiments. Results Analysis of proteins expression After DIGE (Fig. 1), the gel was scanned by a Typhoon Scanner and the relative amount of protein from sample 1 (treated hamster) as compared to sample 2 (control hamster) was determined (Figs. 2, 3). A green spot indicates that the amount of protein from sodium arsenite-treated hamster sample was less than that of the control sample. A red spot indicates that the amount of protein from the sodium arsenite-treated hamster sample was greater than that of the control sample. A yellow spot indicates sodium arsenite-treated hamster and control hamster each had the same amount of that protein. Several protein spots were up-regulated (red) or down-regulated (green) in the urinary bladder samples of hamsters exposed to sodium arsenite (173 mg As/L) for 6 days as compared with the urinary bladder of controls (Fig. 2). In the case of liver, several protein spots were also over-expressed (red) or under-expressed (green) for hamsters exposed to sodium arsenite (173 mg As/L) in drinking water for 6 days (Fig. 3). The urinary bladder samples were collected from the first and second experiments in which hamsters were exposed to sodium arsenite (173 mg As/L) in drinking water for 6 days and the controls were given tap water. The urinary bladder samples from the 1st and 2nd experiments were run 5 times in DIGE gels on different days. The protein expression is shown in Figure 2 and Table 1. The liver samples from the 1st and 2nd experiments were also run 3 times in DIGE gels on different days. The proteins expression were shown in Figure 3 and Table 2. The volume ratio changed of the protein spots in the urinary bladder and liver of hamsters exposed to arsenite were significantly differences than that of the control hamsters (Table 1 and 2). Protein spots identified by LC-MS/MS Bladder The spots of interest were removed from the gel, digested, and their identities were determined by LC-MS/MS (Fig. 2 and Table 1). The spots 1, 2, & 3 from the gel were analyzed and were repeated for the confirmation of the results (experiments; 173 mg As/L). The proteins for the spots 1, 2, and 3 were identified as transgelin, transgelin, and glutathione S-transferase Pi, respectively (Fig. 2). Liver We also identified some of the proteins in the liver samples of hamsters exposed to sodium arsenite (173 mg As/L) in drinking water for 6 days (Fig. 3). The spots 4, 5, & 6 from the gels were analyzed and were repeated for the confirmation of the results. The proteins for the spots 4, 5, and 6 were identified as ornithine aminotransferase, senescence marker protein 30, and fatty acid binding protein, respectively (Fig. 3) Discussion The identification and functional assignment of proteins is helpful for understanding the molecular events involved in disease. Weexposed hamsters to sodium arsenite in drinking water. Controls were given tap water. DIGE coupled with LC-MS/MS was then used to study the proteomic change in arsenite-exposed hamsters. After electrophoresis DeCyder software indicated that several protein spots were down-regulated (green) and several were up-regulated (red). Our overall results as to changes and functions of the proteins we have studied are summarized in Table 3. Bladder In the case of the urinary bladder tissue of hamsters exposed to sodium arsenite (173 mg As/L) in drinking water for 6 days, transgelin was down-regulated and GST-pi was up-regulated. This is the first evidence that transgelin is down-regulated in the bladders of animals exposed to sodium arsenite. Transgelin, which is identical to SM22 or WS3-10, is an actin cross linking/gelling protein found in fibroblasts and smooth muscle [28, 29]. It has been suggested that the loss of transgelin expression may be an important early event in tumor progression and a diagnostic marker for cancer development [30-33]. It may function as a tumor suppressor via inhibition of ARA54 (co-regulator of androgen receptor)-enhanced AR (androgen receptor) function. Loss of transgelin and its suppressor function in prostate cancer might contribute to the progression of prostate cancer [30]. Down-regulation of transgelin occurs in the urinary bladders of rats having bladder outlet obstruction [32]. Ras-dependent and Ras-independent mechanisms can cause the down regulation of transgelin in human breast and colon carcinoma cell lines and patient-derived tumorsamples [33]. Transgelin plays a role in contractility, possibly by affecting the actin content of filaments [34]. In our experiments loss of transgelin expression may be associated or preliminary to bladder cancer due to arsenic exposure. Arsenite is a carcinogen [1]. In our experiments, LC-MS/MS analysis showed that two spots (1 and 2) represent transgelin (Fig. 2 and Table 1). In human colonic neoplasms there is a loss of transgelin expression and the appearance of transgelin isoforms (31). GST-pi protein was up-regulated in the bladders of the hamsters exposed to sodium arsenite. GSTs are a large family of multifunctional enzymes involved in the phase II detoxification of foreign compounds [35]. The most abundant GSTS are the classes alpha, mu, and pi classes [36]. They participate in protection against oxidative stress [37]. GST-omega has arsenic reductase activity [38]. Over-expression of GST-pi has been found in colon cancer tissues [39]. Strong expression of GST-pi also has been found in gastric cancer [40], malignant melanoma [41], lung cancer [42], breast cancer [43] and a range of other human tumors [44]. GST-pi has been up-regulated in transitional cell carcinoma of human urinary bladder [45]. Up-regulation of glutathione – related genes and enzyme activities has been found in cultured human cells by sub lethal concentration of inorganic arsenic [46]. There is evidence that arsenic induces DNA damage via the production of ROS (reactive oxygen species) [47]. GST-pi may be over-expressed in the urinary bladder to protect cells against arsenic-induced oxidative stress. Liver In the livers of hamsters exposed to sodium arsenite, ornithine amino transferase was over-expressed, senescence marker protein 30 was under-expressed, and fatty acid binding protein was under-expressed. Ornithine amino transferase has been found in the mitochondria of many different mammalian tissues, especially liver, kidney, and small intestine [48]. Ornithine amino transferase knockdown inhuman cervical carcinoma and osteosarcoma cells by RNA interference blocks cell division and causes cell death [49]. It has been suggested that ornithine amino transferase has a role in regulating mitotic cell division and it is required for proper spindle assembly in human cancer cells [49]. Senescence marker protein-30 (SMP30) is a unique enzyme that hydrolyzes diisopropylphosphorofluoridate. SMP30, which is expressed mostly in the liver, protects cells against various injuries by stimulating membrane calcium-pump activity [50]. SMP30 acts to protect cells from apoptosis [51]. In addition it protects the liver from toxic agents [52]. The livers of SMP30 knockout mice accumulate phosphatidylethanolamine, cardiolipin, phosphatidyl-choline, phosphatidylserine, and sphingomyelin [53]. Liver fatty acid binding protein (L-FABP) also was down- regulated. Decreased liver fatty acid-binding capacity and altered liver lipid distribution hasbeen reported in mice lacking the L-FABP gene [54]. High levels of saturated, branched-chain fatty acids are deleterious to cells and animals, resulting in lipid accumulation and cytotoxicity. The expression of fatty acid binding proteins (including L-FABP) protected cells against branched-chain saturated fatty acid toxicity [55]. Limitations: we preferred to study the pronounced spots seen in DIGE gels. Other spots were visible but not as pronounced. Because of limited funds, we did not identify these others protein spots. In conclusion, urinary bladders of hamsters exposed to sodium arsenite had a decrease in the expression of transgelin and an increase in the expression of GST-pi protein. Under-expression of transgelin has been found in various cancer systems and may be associated with arsenic carcinogenicity [30-33). Inorganic arsenic exposure has resulted in bladder cancer as has been reported in the past [1]. Over-expression of GST-pi may protect cells against oxidative stress caused by arsenite. In the liver OAT was up regulated and SMP-30 and FABP were down regulated. These proteomic results may be of help to investigators studying arsenic carcinogenicity. The Superfund Basic Research Program NIEHS Grant Number ES 04940 from the National Institute of Environmental Health Sciences supported this work. Additional support for the mass spectrometry analyses was provided by grants from NIWHS ES06694, NCI CA023074 and the BIOS Institute of the University of Arizona. Acknowledgement The Author wants to dedicate this paper to the memory of his former supervisor Dr. H. VaskenAposhian who passed away in September 6, 2019. He was an emeritus professor of the Department of Molecular and Cellular Biology at the University of Arizona. 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Összefoglaló. A doktori képzés területén jelentős nemzetközi átrendeződés történt a 2000-es évektől. Magyarország a doktori képzés rendszerváltás utáni kialakításakor a stabilabb képzési környezetet teremtő programmodell mellett döntött, azonban a globális kihívások (hosszú képzési idő, tanulói státusz) a magyarországi doktori képzést is érintik. Ez indokolta a doktori képzés struktúraváltását 2016-ban. Tanulmányunkban áttekintjük a nemzetközi és hazai változásokat a képzésben, s képet adunk a hazai beiskolázási adatokról is, melyekhez a Központi Statisztikai Hivatal, az Országos Doktori Tanács, a Diplomás Pályakövetési Rendszer (N = 509) és a Persist (N = 1020) létszámadatait és adatbázisait használtuk. Eredményeinkből egy lassan növekvő és tudományterületileg erősen tagolt doktorandusz-társadalom képe bontakozik ki. Tanulmányunk fontos megállapítása, hogy a doktori képzés vonzását a felsőoktatás korábbi szintjein szerzett kedvező tapasztalatokkal lehet növelni. Summary. There has been a significant international reorganization in the field of doctoral training since the 2000s. After the change of regime, Hungary opted for a program model that created a more stable training environment, but global challenges (e.g. long training time, student status) also affect doctoral training in Hungary. These problems led to a structural change in doctoral training in 2016. In our study, we review international and domestic changes in education, and provide an overview of domestic enrollment data, for which we analyze the headcount data and databases of the Central Statistical Office, the National Doctoral Council, the Graduate Career Tracking System (N = 509) and Persist (N = 1020). In our results, we present an expanding, but highly divided doctoral student society. An important finding of our study is that the attractiveness of doctoral training can be increased by the positive experience gained at previous levels of higher education.

Background: As the global climate changes, the number of cases of hand-foot-and-mouth disease (HFMD) is increasing year by year. This study comprehensively considers the association of time and space by analyzing the temporal and spatial distribution changes of HFMD in the Ili River Valley in terms of what climate factors could affect HFMD and in what way. Methods: HFMD cases were obtained from the National Public Health Science Data Center from 2013 to 2018. Monthly climate data, including average temperature (MAT), average relative humidity (MARH), average wind speed (MAWS), cumulative precipitation (MCP), and average air pressure (MAAP), were obtained from the National Meteorological Information Center. The temporal and spatial distribution characteristics of HFMD from 2013 to 2018 were obtained using kernel density estimation (KDE) and spatiotemporal scan statistics. A regression model of the incidence of HFMD and climate factors was established based on a geographically and temporally weighted regression (GTWR) model and a generalized additive model (GAM). Results: The KDE results show that the highest density was from north to south of the central region, gradually spreading to the whole region throughout the study period. Spatiotemporal cluster analysis revealed that clusters were distributed along the Ili and Gongnaisi river basins. The fitted curves of MAT and MARH were an inverted V-shape from February to August, and the fitted curves of MAAP and MAWS showed a U-shaped change and negative correlation from February to May. Among the individual climate factors, MCP coefficient values varied the most while MAWS values varied less from place to place. There was a partial similarity in the spatial distribution of coefficients for MARH and MAT, as evidenced by a significant degree of fit performance in the whole region. MCP showed a significant positive correlation in the range of 15–35 mm, and MAAP showed a positive correlation in the range of 925–945 hPa. HFMD incidence increased with MAT in the range of 15–23 °C, and the effective value of MAWS was in the range of 1.3–1.7 m/s, which was positively correlated with incidences of HFMD. Conclusions: HFMD incidence and climate factors were found to be spatiotemporally associated, and climate factors are mostly non-linearly associated with HFMD incidence.

Background The COVID-19 global pandemic caused a complete stop in sport participation which meant a detraining period for athletes. High-level athletes had to train at home guided by their coaches and conditioning trainers in an effort to maintain their physical fitness. The aim of maintaining the training adaptations and physical fitness during the COVID-19 mandatory lockdown was especially important for CP athletes, in which the detraining period was expected to cause early declines in motor function, poor coordination and muscle weakness due to their disability. Methods The present study assessed the effect of a guided self-training program on international CP football players’ physical fitness during the COVID-19 mandatory lockdown. Fifteen CP football players from the Spanish National Team participated in the study. An experimental design with a pre- (T1) and a post-intervention (T2) assessment was carried out, with a 12-week period of players’ self-training (divided in two periods of 6 weeks) which combined strength and endurance training. Physical performance assessment consisted in the free countermovement jump (CMJ), 5, 10 and 20-m sprint, the modified agility T-test (MAT) and a dribbling test. The Kruskal–Wallis test was used for between-group comparisons, while the Student’s paired t test or the Fisher Pitman permutation test, based on the normality of the data, were used for within-group comparisons. Results The results showed no differences between sport classes (FT1, FT2 and FT3) in physical fitness change after the training program (Chi2 = 0.16 to 1.73; p = 0.42 to 0.92). Within-group comparisons showed an increase of jump height in the CMJ (4.19 cm [2.46, 5.93]; p < 0.001) and a maintenance of the 5, 10 and 20-m sprint, MAT and dribbling ability (<0.01 to 0.09 s; p = 0.19 to 0.97). Discussion To the authors’ knowledge, this is the first study that examined the physical fitness adaptations to a training program with CP football players. The results show that a 12-week guided self-training program without football-specific stimulus may be effective to maintain or even improve the specific physical performance of international CP football players during a non-competitive period (as the COVID-19 lockdown). This study reveals that CP football players are able to show adaptations to the strength and endurance training and this could be the basis for future research regarding training adaptations in CP football players.

Canada’s forests play an important role in the global carbon (C) cycle. Forest management activities, implemented at the operational scale, can have a significant impact on the C budget of Canada’s forests. With the increasing national and international recognition that forest management activities can contribute to national C sources and sinks, forest managers could benefit from having a scientifically credible tool to assess the potential impacts of alternate management activities on the C stocks and stock changes on their land base. Such a tool must incorporate the best available science, be compliant with evolving international accounting rules and have enough flexibility to address the types of scenarios and management questions that are of interest to forest managers. To be cost effective and efficient for use by forest managers, the tool should make use of existing information on inventory, growth and yield, and disturbances that their analysts routinely use in their forest management planning activities. The readily available information must be augmented with additional data and modelling to estimate changes in those C pools that are not commonly included in forest inventories, such as carbon in the dead organic matter associated with litter, coarse woody debris and soil C. Building upon the past decade of work in the development and application of the C Budget Model of the Canadian Forest Sector (CBM-CFS2), the Canadian Forest Service C Accounting Team is now working with the Model Forest Network to develop, test and deliver an operational scale C accounting tool and its supporting databases with regional parameter values. When fully developed (2004), the operational model will be made available without charge to anyone interested in using it to estimate landscape level forest C stocks and C stock changes. Expertise developed within the extensive network of Model Forests and their partners in Canada will facilitate technology transfer and training of the larger user community. The tools and the technology transfer program will empower forest managers to include considerations of the impacts of the planned activities on forest C stocks. This will increase the potential use of forests and forest management activities in contributing towards a greenhouse gas emission reduction strategy. Key words: carbon cycle, carbon accounting, forest management, operational scale, land-use change, model forests, CBM-CFS2

Eating habits develop during the first years of a child's life, children learn what, when, and how much to eat through direct experience with food and by observing the eating habits of others. The aim of this study is to get a clear picture of the Eating program Healthy, starting from the planning, implementation, supervision, and evaluation as a case study of nutrition education; to get information about the advantages, disadvantages and effects of implementing a healthy eating program for children. This research was conducted through a case study with qualitative data analysed using Miles and Huberman techniques. Sample of children in Ananda Islāmic School Kindergarten. The results showed the Healthy Eating program could be implemented well, the diet was quite varied and could be considered a healthy and nutritious food. The visible impact is the emotion of pleasure experienced by children, children become fond of eating vegetables, and make children disciplined and responsible. Inadequate results were found due to the limitations of an adequate kitchen for cooking healthy food, such as cooking activities still carried out by the cook himself at the Foundation's house which is located not far from the school place; use of melamine and plastic cutlery for food; the spoon and fork used already uses aluminium material but still does not match its size; does not involve nutritionists. Keywords: Early Childhood, Eating Healthy Program References: Bandura, A. (1977). Social learning theory. Englewood Cliffs: Prentice-Hall. Bandura, Albert. (2004). Health promotion by social cognitive means. Health Education and Behavior, 31(2), 143–164. https://doi.org/10.1177/1090198104263660 Battjes-Fries, M. C. E., Haveman-Nies, A., Renes, R. J., Meester, H. J., & Van’T Veer, P. (2015). Effect of the Dutch school-based education programme “Taste Lessons” on behavioural determinants of taste acceptance and healthy eating: A quasi-experimental study. 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Based on the data of daily maximum temperature in 26 meteorological stations in the North Center Region, Vietnam over the period of 1980 to 2013, the authors conducted the research on the spatial distribution of the number of hot days. The initial result shows that in general, in the north of the study area, the large number of hot days occurred in the plain, and tended to decrease westward and eastward. In the south, this number tends to increase from the west to the east. Especially, the largest number occurred in two areas: The Ma and Ca River's valleys (Thanh Hoa and Nghe An provinces) and the coastal areas (Thua Thien Hue province), creating two heat centers in Tuong Duong district, Nghe An province and Nam Dong district, Thua Thien Hue province.ReferencesAdina-Eliza Croitoru, Adrian Piticar, Antoniu-Flavius Ciupertea, Cristina FlorinaRosca, 2016 Changes in heat wave indices in Romania over the period 1961-2015. Global and Plantary Change 146. Journal homepage: www. 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Background: Although adequate research has been conducted regarding smoking and smokeless tobacco, there is a dearth of research exploring reasons for chewing areca nut and betel-quid. Global epidemiology of areca nut and betel-quid shows distinct ethnic and cultural preferences. Areca nut is chewed for its psychological stimulating effects and perhaps, a medicinal value. To develop empirically supported treatments and to promote nonstarting, healthcare workers and researchers must first understand the reasons people engage in the behavior. Aim: To discuss evidence based approaches and strategies for habit intervention in smokeless tobacco/arecanut/betel-quid and nonstarting. Methods: Data were collected from published national and international research, conference reports, WHO reports, tobacco control guides, Clinical Best Practice Guidelines and Cochrane database systematic reviews. Results: Individual behaviors are largely determined by complex range of factors beyond the control of the most individuals. Behavior change is complex and most people are well-informed about the basic health messages. Most people will have extensive experience of attempting to change their health career including quitting tobacco products. It is therefore essential to know a detailed history of a person's previous experiences of change and learn from this. Interventions need to match individuals' desire and ability to change. Encouragement, understanding, support, and empathy are all essential to enable clients achieve their goals. The most effective preventive intervention that a clinician can provide for tobacco-using patients against is an empathic, personalized smoking cessation intervention program with extended assistance and follow-up. The goal of the intervention must be complete cessation. Reduction provides no direct health benefits to the individual. Oral examination by a dental professional who points out tissue damage from smokeless tobacco use in a user´s own mouth, advice to quit, and brief problem solving and supportive counseling are effective in promoting smokeless tobacco cessation. There is also a need to develop culturally tailored areca nut and betel-quid cessation and risk reduction programs, the first step in reducing the public health burden associated with betel-quid chewing worldwide. Interventions are available, but underutilized, in part due to lack of clinician training and organizational support. Conclusion: Although the deleterious effects of smokeless tobacco/areca nut/betel-quid are well known by both users and healthcare workers, the knowledge has not translated effectively into cessation. Proven, brief, repetitive, directed interventions tailored to the needs of the patients can increase successful cessation. Controlling sociodemographic, environmental and personal factors may promote nonstarting.

Relevance Antimicrobial resistance (AMR) is a growing acute global health issue. Uncontrolled combined use of antibiotics determines changes in the microbial agents' properties, leading to a decrease of susceptibility to antimicrobial substances and increasing the probability of severe invasive bacterial infections with limited possibilities to treat them. Vaccination against pneumococcal infection as well as improvement of the health care providers awareness can be considered as part of AMR management strategies. A number of epidemiological observations have been published indicating a change in antimicrobial resistance to Streptococcus pneumoniae following the implementation of the national infant immunization program against pneumococcal infection. Aim. To analyze the literature data on the pneumococcal vaccination contribution to the reduction of the number of pneumococcal diseases and the need for antibacterial therapy and to assess the burden of invasive pneumococcal diseases globally and in the Republic of Belarus (RB) and to identify gaps in the awareness of practicing physicians on pneumococcal infection immunoprophylaxis, its' effectiveness and impact on AMR. Conclusions. WHO considers and promote vaccination as an AMR containment measure. There are a lot of publications with the examples of countries with pneumococcal infection pediatric national immunization programs (NIP) and epidemiological data on changes in the S.pneumoniae sensitivity to antibacterial drugs after the start of the NIP. During the period of the mass PCV immunization and the subsequent drift of strains the sensitivity to antimicrobials may return. In Israel 88% and 93% reduction of otitis media cases caused by resistant to penicillin and macrolides vaccine types of S.pneumoniae after the phased introduction of PCV7 and PCV13 to the infant NIP, comparing to the period before vaccination introduction. A decrease in the frequency of bacteremia in combination with a sharp decrease in the proportion of penicillin-resistant pneumococcal isolates (from 50.9% to 5.3%) is also described. In France the proportion of S.pneumoniae strains with reduced susceptibility or resistance to penicillin declined from 47.1% to 39% after the start of PCV13 NIP; researchers also noted a decrease in antibiotic-resistant isolates of S.pneumoniae in children with otitis media: by 26, 31, 55, 29 and 57%, respectively, to penicillin, amoxicillin, cefotaxime, erythromycin and co-trimoxazole to in 2011. A study in Germany revealed a decrease in macrolide-resistant IPD strains after the start of PCV13 use of (in children 8.2%; in adults 8.8%) compared with the period after the introduction of PCV7 (17.3% and 13.0%) and especially in the cohort of children compared with the period before the use of PCV7 (24.8% and 13.3%). In Scotland, there was a decrease in the number of penicillin-resistant strains isolated from the blood of patients with IPD after the introduction of PCV13 into the NIP. The publication of the results of three parallel studies in Finland evaluated the effectiveness of PCV10 in reducing the number of IPD caused by vaccine-specific serotypes of PCV10 by 93%, 98% and 100%, respectively. At the same time, the effectiveness against «related» PCV10 serotypes was equal to 46%, 51% and 78%, respectively, and the estimated effectiveness against unrelated PCV10 serotypes was negative. Composition and resistance profile of the lower respiratory tract microflora isolated from sputum pneumococcal strains in children in 2016–2018, demonstrated up to 72.4% resistance to macrolides, 31.3% resistance to cefotaxime and 8.3% – to ceftriaxone. Spn serotypes structure in under 5 years of age children with meningitis was characterized by relatively high uniformity. Majority (92%) of multiresistant meningeal strains are covered by current PCVs. An anonymous questionnaire showed pediatricians' insufficient awareness about current approaches to pneumococcal infection prevention, underestimation of IPD risks and complications, and the impact of vaccination on reducing AMR. Additional education is required to increase the level of knowledge and understanding of the PCVs role in AMR reduction. PCV NIP introduction will provide additional opportunities to reduce AMR in the Republic of Belarus.

e23169 Background: A breast cancer diagnosis has the greatest disability-adjusted life years lost of all cancers and significant impact on physical, psychoemotional, social and overall global functioning. Directed by Breast Cancer Canada, a registered non-profit patient-led organization and data managed by the University of Calgary’s POET Program, PROgress Tracker uses a novel, peer-to-peer support model for recruitment, engagement and retention, and is the first national longitudinal and non-interventional PROMs registry. Our aim is to demonstrate the feasibility and potential of this registry in centering patient voice and lived experience to transform breast cancer management. Methods: PROgress Tracker, with 10-year enrollment goal of 50,000 Canadians with Stage 0-IV breast cancer, extends a series of validated PROMs (PROMIS, BREAST-Q, FACT-B, GAD, PHQ-9, COST-FACIT, ISI and ESASr-CA) via a digital platform every 3 months for up to 10 years. Dynamic customization of additional PROMs (PRO-CTCAE, BREAST-Q) based on patient and treatment-specific trigger questions assess evolving components of wellbeing, including financial stress, work life and adverse treatment effects. Results: Recruitment began in October 2023. 162 participants from all Canadian regions including remote/rural geographic areas have shared baseline demographic and clinical data including stage, genetic/molecular tumor markers, treatment type(s) and completed an initial series of PROMs. Comprehensive PROMs including sensitive topics (finances, sexuality, mental health) were completed with minimal missing data ( < 5%); 3-month follow-up surveys show a current retention rate of 57%. Preliminary analysis: median age of participants 54 yrs, 95% identify as Caucasian, and 57% are currently working. 46% reported financial stress (99% response rate); 63% reported ongoing symptoms requiring follow-up. 6% were BRCA+ and 19% triple negative, 7% experienced recurrence, 3% Stage IV, 75% received systemic and/or radiation therapy, 38% received targeted therapy. Conclusions: The lived experience of breast cancer is integral to patient-centred change in the era of precision/personalized medicine and is captured by PROgress Tracker using a diverse set of periodic PROMs to understand the evolution of global measures of wellbeing over time. Initial data indicates that this novel peer to peer model via digital administration of comprehensive and longitudinal PROMs is feasible. This initiative demonstrates attaining this scope of data is achievable, has interest and participation from the national breast cancer community and growing capacity to accrue important, real-time data to inform best practice and identify additional supports required for breast cancer care. While early feasibility is evident, further outreach and recruitment initiatives will ensure diversity of participants.

Context Typically, athletic trainers rely on clinician-centered measures to evaluate athletes' return-to-play status. However, clinician-centered measures do not provide information regarding patients' perceptions. Objective To determine whether clinically important changes in patient-reported outcomes were observed from the time of lower extremity injury to the time of return to play in adolescent athletes. Design Cross-sectional study. Setting The National Athletic Treatment, Injury and Outcomes Network (NATION) program has captured injury and treatment data in 31 sports from 147 secondary schools across 26 states. A subsample of 24 schools participated in the outcomes study arm during the 2012−2013 and 2013−2014 academic years. Patients or Other Participants To be included in this report, student-athletes must have sustained a knee, lower leg, ankle, or foot injury that restricted participation from sport for at least 3 days. A total of 76 initial assessments were started by athletes; for 69 of those, return-to-play surveys were completed and analyzed. Main Outcome Measure(s) All student-athletes completed generic patient-reported outcome measures (Patient-Reported Outcomes Measurement Information System [PROMIS] survey, Global Rating of Change scale, and Numeric Pain Rating Scale) and, depending on body region, completed an additional region-specific measure (Knee Injury and Osteoarthritis Outcome Score or Foot and Ankle Ability Measure). All applicable surveys were completed at both the initial and return-to-play time points. Means and standard deviations for the total scores of each patient-reported outcome measure at each time point were calculated. Change scores that reflected the difference from the initial to the return-to-play time points were calculated for each participant and compared with established benchmarks for change. Results The greatest improvement in patient-reported outcomes was in the region-specific forms, with scores ranging from 9.92 to 37.73 on the different region-specific subscales (Knee Injury and Osteoarthritis Outcome Score or Foot and Ankle Ability Measure; scores range from 0−100). The region-specific subscales on average still showed a 21.8- to 37.5-point deficit in reported health at return to play. The PROMIS Lower Extremity score increased on average by 13 points; all other PROMIS scales were within normative values after injury. Conclusions Adolescent athletes who were injured at a high school with an athletic trainer may have shown improvement in patient-reported outcomes over time, but when they returned to play, their outcome scores remained lower than norms from comparable athlete groups.

Climate change induced sea-level rise (SLR) is on its increase globally. Regionally the lowlands of China, Vietnam, Bangladesh, and islands of the Malaysian, Indonesian and Philippine archipelagos are among the world’s most threatened regions. Sea-level rise has major impacts on the ecosystems and society. It threatens coastal populations, economic activities, and fragile ecosystems as mangroves, coastal salt-marches and wetlands. This paper provides a summary of the current state of knowledge of sea level-rise and its effects on both human and natural ecosystems. The focus is on coastal urban areas and low lying deltas in South-East Asia and Vietnam, as one of the most threatened areas in the world. About 3 mm per year reflects the growing consensus on the average SLR worldwide. The trend speeds up during recent decades. The figures are subject to local, temporal and methodological variation. In Vietnam the average values of 3.3 mm per year during the 1993-2014 period are above the worldwide average. Although a basic conceptual understanding exists that the increasing global frequency of the strongest tropical cyclones is related with the increasing temperature and SLR, this relationship is insufficiently understood. Moreover the precise, complex environmental, economic, social, and health impacts are currently unclear. SLR, storms and changing precipitation patterns increase flood risks, in particular in urban areas. Part of the current scientific debate is on how urban agglomeration can be made more resilient to flood risks. Where originally mainly technical interventions dominated this discussion, it becomes increasingly clear that proactive special planning, flood defense, flood risk mitigation, flood preparation, and flood recovery are important, but costly instruments. 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Cobalt is a highly important metal that is widely used in lithium-ion batteries, cemented carbide, magnetic materials, chemical, and medical industries. The current global cobalt reserves (in total around 6.9 million tons) are unevenly distributed mainly between the Democratic Republic of Congo (48%) and Australia (21%) [1]. One of the main sources of cobalt is nickel production where Co is as a byproduct. Nevertheless, research related to cobalt extraction from both primary or secondary resources must be accelerated to address the current imbalance between supply and demand, that has resulted in cobalt being classified as highly critical by the EU [2]. Currently, primary and secondary raw materials are refined using pyro-hydrometallurgical or hydrometallurgical processing routes, followed by e.g. cobalt crystallization, or electrowinning. Battery grade cobalt salts can be further subjected for calcination to form battery grade oxides. In the current study, we investigate a novel approach of electrifying metallurgy - attempting for direct electrochemical cobalt recovery as cobalt oxide from a hydrometallurgical chloride based process solution. Potentiostatic electrolysis was performed in synthetic cobalt chloride solution, mimicking the industrial concentrations. SEM and EDX were used for microstructural characterization and determination of sample compositions, respectively. Cyclic voltammetry (CV) was also carried out to understand the anodic behavior of cobalt on the Pt electrode. CV studies suggested the formation of different cobalt-containing phases and the obtained precipitates in potentiostatic experiments were identified as Co3O4 and CoOOH. However, the precipitate composition was strongly dependent on the conditions of electrolysis, such as potential, temperature, and pH. At the highest studied potential (1150 mV vs. Ag/AgCl) the precipitate obtained had a saturated black color indicating desired formation of Co3O4, while at lower potentials the brown colour indicated dominance of other phases. The microstructure of the electrodes due to different potentials was investigated by SEM, indicating also morphology changes as a function of recovery potential. EDX analysis suggested that the precipitates recovered included not only cobalt and oxygen but also traces of chloride ions. Overall, this study highlights the possibility of cobalt recovery in oxide form in a chloride medium as an alternative method for the recovery of cobalt from industrial process solutions. The proposed approach can be suggested as an alternative to the traditional process of crystallization or electrowinning. In addition, cobalt obtained in a form of oxide is an important class of materials characterized by good electrochemical, catalytic, and optical properties and can be used as a final product in a variety of applications if quality requirements can be achieved. Acknowledgment The ENICON project (https://enicon-horizon.eu/) has received funding from the European Union’s Framework Program for Research and Innovation Horizon Europe under Grant Agreement No. 101058124 References Rahimpour Golroudbary, S.; Farfan, J.; Lohrmann, A.; Kraslawski, A. Environmental Benefits of Circular Economy Approach to Use of Cobalt. Global Environmental Change (2022) 76, doi:10.1016/j.gloenvcha.2022.102568. Blengini, G.A.; EL Latunussa, C.; Eynard, U.; Torres de Matos, C.; Wittmer, D.; Georgitzikis, K.; Pavel, C.; Carrara, S.; Mancini, L.; Unguru, M.; et al. Study on the EU’s List of Critical Raw Materials (2020) Final Report., doi:10.2873/904613.

The challenge for rural communities to provide quality education for early childhood in Indonesia is difficult. National politics, policies, and economic and cultural conditions affect the Early Childhood Education system, and Indonesia is a large multicultural country, so, even the quality of education is difficult. This study aims to look at the quality of children's education in Pandalungan. Using qualitative methods with ethnographic design, data collection techniques using interviews, observation, and documentation. The results showed that educational institutions for children in urban areas can be categorized quite high. However, for early childhood education services in Desa Sukorambi Pandalungan, the quality is quite poor. Research suggestions are the need for follow-up related to social, economic, cultural and environmental factors at the level of Pandalungan community awareness of early childhood education. 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ABSTRAK Tujuan utama dari makalah ini untuk menguji secara empiris pengaruh zakat, Produk Domestik Regional Bruto (PDRB) perkapita, Upah Minimum Regional/Provinsi (UMP), dan inflasi terhadap tingkat gini rasio di 34 provinsi di Indonesia selama tahun 2018-2020. Temuan penelitian ini menunjukkan bahwa distribusi zakat yang diproksikan dengan Indeks Kesejahteraan BAZNAS serta tingkat inflasi secara statistik tidak berpengaruh signifikan terhadap tingkat ketimpangan pendapatan di Indonesia. Sementara itu, tingkat PDRB perkapita dan UMP memiliki arah hubungan negatif dan berpengaruh signifikan secara statistik terhadap tingkat ketimpangan pendapatan di Indonesia. Penelitian ini memberikan rekomendasi kepada pengelola zakat untuk menciptakan dan mengembangkan program zakat yang mampu memberdayakan perekonomian mustahik sehingga mampu mengurangi tingkat kesenjangan pendapatan dalam masyarakat. Selain itu, seluruh pemangku kepentingan (stakeholders) harus bersinergi dalam upaya meningkatkan realisasi pengumpulan dana zakat di lembaga dengan melalui peningkatan literasi dan kesadaran masyarakat guna mengoptimalisasikan peran zakat dalam peningkatan kesejahteraan masyarakat. Kata kunci: Indeks Kesejahteraan BAZNAS, Ketimpangan Pendapatan, Makroekonomi, Zakat. ABSTRACT The main objective of this paper was to empirically examine the effect of zakat, Gross Regional Domestic Product (GRDP) percapita, Regional/Provincial Minimum Wage, and inflation on the gini ratio in 34 provinces in Indonesia during 2018-2020. The findings of this study indicate that the distribution of zakat, which is proxied by the BAZNAS Welfare Index, and the inflation rate has no statistically significant effect on the level of income inequality in Indonesia. Meanwhile, GRDP per capita and Regional/Provincial Minimum Wage levels have a negative and statistically significant relationship to the level of income inequality in Indonesia. In order to lessen the degree of income inequality in society, this study offers recommendations to zakat managers on how to design and develop zakat programs that can strengthen the mustahik's economy. In addition, all stakeholders must work together in an effort to increase the realization of zakat fund collection in institutions by increasing literacy and public awareness in order to maximize the contribution of zakat to raising the welfare of mankind. Keywords: Baznas Welfare Index, Income Inequality, Macroeconomics, Zakat. REFERENCES Abdelbaki, D. H. H. (2013). The impact of zakat on poverty and income inequality in Bahrain. Review of Integrative Business & Economics Reseacrh, 2(1), 133–154. Afandi, A., Rantung, V. P., & Marashdeh, H. (2017). Determinants of income inequality. 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ABSTRACT Islamic banking in Indonesia and Malaysia experienced differences in asset growth and market share, potentially causing dissimilarity in profitability performance. This study aims to evaluate the factors that influence the increase in profitability of Islamic banking in Indonesia and Malaysia using signaling theory including market concentration (HHI), company size and financing risk (NPF), and national income (GDP) as control variables. It analyzed the Indonesian and Malaysian Islamic banks during the period 2017-2021. The method used in this study is comparative descriptive with panel data regression analysis measuring instruments. Based on the results of empirical analysis, factors that affect the profitability of Islamic banking in Indonesia are financing risk, while in Malaysia, it is financing risk and national income. The results of this study update the view on the profitability of Islamic banking in Indonesia and Malaysia. In addition, from the managerial side, this study contributes to creating NPF control in Indonesian Islamic banking because these factors can increase the profitability of the country's Islamic banking. The study also contributes to the development of market concentration strategies, company size, and financing risks in Malaysian Islamic banking as all these factors can increase the profitability of the country's Islamic banking. Keywords: Islamic Banking, Profitability, Market Concentration, Company Size, Financing Risk ABSTRAK Perbankan syariah Indonesia dan Malaysia mengalami perbedaan dalam pertumbuhan aset dan market share sehingga berpotensi menimbulkan perbedaan kinerja profitabilitas. Studi ini bertujuan untuk mengevaluasi faktor yang mempengaruhi peningkatan profitabilitas perbankan syariah di Indonesia dan Malaysia dengan menggunakan signaling theory diantaranya konsentrasi pasar (HHI), ukuran perusahaan dan risiko pembiayaan (NPF) serta pendapatan nasional (GDP) sebagai variabel kontrol. Studi ini menganalisis bank syariah di Indonesia dan Malaysia selama periode 2017-2021. Metode yang digunakan oleh studi ini adalah komparatif deskriptif dengan alat ukur analisis regresi data panel. Berdasarkan hasil analisis empiris, faktor yang mempengaruhi profitabilitas perbankan syariah Indonesia adalah risiko pembiayaan sedangkan di Malaysia adalah risiko pembiayaan serta pendapatan nasional. Hasil penelitian ini memperbaharui pandangan tentang profitabilitas perbankan syariah Indonesia dan Malaysia. Selain itu dari sisi manajerial, studi ini berkontribusi dalam menciptakan pengendalian NPF pada perbankan syariah Indonesia karena faktor tersebut mampu meningkatkan profitabilitas perbankan syariah negara tersebut. Selain itu studi ini juga berkontribusi dalam pengembangan strategi konsentrasi pasar, ukuran perusahaan dan risiko pembiayaan pada perbankan syariah Malaysia karena semua faktor tersebut mampu meningkatkan profitabilitas perbankan syariah negara tersebut. Kata Kunci: Bank Syariah, Profitabilitas, Konsentrasi Pasar, Ukuran Perusahaan, Risiko Pembiayaan REFERENCE Abbas, A., & Arizah, A. (2019). Marketability, profitability, and profit-loss sharing: evidence from sharia banking in Indonesia. Asian Journal of Accounting Research, 4(2), 315–326. doi:10.1108/AJAR-08-2019-0065 Adelopo, I., Lloydking, R., & Tauringana, V. (2018). Determinants of bank profitability before, during, and after the financial crisis. 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Carbon dioxide emission on peatland under oil palm plantation were highly varied probably due to many factors involved. The objectives of the research were to evaluate the effect of distance sampling from center of oil palm tree on Carbon dioxide flux, and to study the factors that cause variability of carbon dioxide flux on peatland under oil palm plantation. The study was conducted on peatland at Arang-Arang Village, Kumpek Ulu Sub-District, Muaro Jambi District, Jambi Province, on six year old oil palm plantation. The study was conducted in the form of observational exploratory. Emission measurements performed on 5 selected oil palm trees at points within 100, 150, 200, 250, 300, 350, and 400 cm from the center of trunk. Carbon dioxide flux was measured using (IRGA), Li-COR 820. The results showed that there is significant correlation between the distance of sampling from center of oil palm tree and Carbon dioxide flux. The farther distance from the tree, Carbon dioxide flux more decreased. Before applying fertilizer, variability of soil fertility was not significantly correlated with the flux of Carbon dioxide, so the difference of Carbon dioxide flux based on distance sampling can be caused by root distribution factor. After fertilizer application, variability of Carbon dioxide flux under the oil palm tree were beside affected by differences in root distribution, was also greatly influenced by fertilization.Keywords: Carbon dioxide flux, distance sampling, oil palm, peat, root-related respiration [How to Cite: Dariah A, F Agus, E Susanti and Jubaedah. 2013.Relationship between Sampling Distance and Carbon Dioxide Emission under Oil Palm Plantation. J Trop Soils 18 (2): 125-130. Doi: 10.5400/jts.2013.18.2.125][Permalink/DOI: www.dx.doi.org/10.5400/jts.2013.18.2.125] REFERENCESAgus F, E Handayani, van M Noordwijk, K Idris and S Sabiham. 2010 Root respiration interferes with peat CO2 emission measurement. 19th World Congress of Soil Science, Soil Solutions for a Changing World. 1 - 6 August 2010, Brisbane, Australia. Published on DVD.Amador JA and RD Jones. 1993. Nutrient limitation on microbial respiration in peat soil with diffrent total phosphorus content. Soil Biol Biochem 25: 793-801.Franklin O, P Hoogberg, A Ekbled and GI Agren. 2003. Pine forest floor carbon accumulation in response to N and PK addition: Bomb C-14 modeling and respiration studies. Ecosystem 6: 644-658. Freeman C, N Ostle and H Kang. 2001. An Enzymic ‘latch’ on global carbon store-a shortage of oxigen locks up carbon in peatlands by restraining a single enzyme. Nature 409: 149-149.Hanson PJ, NT Edwards, CT Garten and JA Andrew. 2000. 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Can Gio mangrove forest (CGM) is located downstream of Ho Chi Minh City (HCMC), situated between an estuarine system of Dong Nai - Sai Gon river and a part of Vam Co river. The CGM is the largest restored mangrove forest in Vietnam and the UNESCO’s Mangrove Biosphere Reserve. The CGM has been gradually facing to numeric challenges of global climate change, environmental degradation and socio-economic development for the last decades. To evaluate sediment quality in the CGM, we collected 13 cores to analyze for sediment grain size, organic matter content, and trace element concentration of Cd, Cr, Cu, Ni, Pb, Zn. Results showed that trace element concentrations ranged from uncontaminated (Cd, Cu, and Zn) to very minor contaminated (Cr, Ni, and Pb). The concentrations were gradually influenced by suspended particle size and the mangrove plants.ReferencesAnh M.T., Chi D.H., Vinh N.N., Loan T.T., Triet L.M., Slootenb K.B.-V., Tarradellas J., 2003. 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Mangroves of Vietnam: Chapter VI Human impacts on the mangrove ecosystem. Bangkok 10501: IUCN - The International Union for Conservation of Nature, ISBN: 2-8317-0166-x.Hubner R., Astin K.B., Herbert R.J., 2009. Comparison of sediment quality guidelines (SQGs) for the assessment of metal contamination in marine and estuarine environments. Journal of Environmental Monitoring, 11, 713–722.IAEA, 2003. Collection and preparation of bottom sediment samples for analysis of radionuclides and trace elements. Vienna, Austria: International Atomic Energy Agency, IAEA-TECDOC-1360, ISBN 92–0–109003–X.Jingchun L., Chongling Y., Ruifeng Z., Haoliang L., Guangqiu Q., 2008. Speciation changes of Cd in mangrove (Kandelia Candel L.) rhizosphere sediments. Bull Environ Contam Toxicol, 231-236. Doi:10.1007/s00128-007-9351-z.Kalaivanan R., Jayaprakash M., Nethaji S., Arya V., Giridharan L., 2017. Geochemistry of Core Sediments from Tropical Mangrove Region of Tamil Nadu: Implications on Trace Metals. 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Why do states want to acquire nuclear weapons? In other words, what drives nuclear-aspiring states? This is the basic question that the author seeks to address in this research. To do so, this research will focus on two standout cases: Iran and North Korea. By employing structural realism as a tool of analysis, the author argues that it is the structure of the international system that drives both Iran and North Korea to acquire nuclear weapons of their own. Specifically, it is the highly unequal distribution of power both regionally and globally that encourages both states to go nuclear. At the global level, both Iran and North Korea found themselves in hostilities with a much more powerful state, the United States. The hostilities and the fact that the United States is way more powerful increase the fear of being attacked in both countries. Similarly, at the regional level, both states face neighbors that are relatively more powerful and have alliances with the United States. Thus, this imbalance of power and the fear it created in both Iran and North Korea give them great incentive to go nuclear, as nuclear weapons would act as a deterrent against any possible aggression. This research is qualitative and based on the literature study data collection method. Keywords: Nuclear proliferation; national security; distribution of capabilities; structural realism REFERENCES Abulof, Uriel. 2014. "Revisiting Iran’s nuclear rationales." International Politics 51(3), 404-415. Albright, David, and Andrea Stricker. 2010. "Iran’s Nuclear Program." In The Iran Primer: Power, Politics, and US Policy, edited by Robin Wright, 77-81. Washington, D.C.: United States Institute of Peace Pres. Bowen, W.Q., and J. Brewer. 2011. "Iran’s nuclear challenge: Nine years and counting." International Affairs 87(4): 923–943. Chubin, S. 2007. "Iran: Domestic politics and nuclear choices." In Strategic Asia 2007–08: Domestic Political Change and Grand Strategy, edited by A.J. Tellis, M. 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Seismic status in Bangladesh has been investigated using earthquake data recorded by the global network of USGS during 1980 to 2016. Seismicity parameters such as magnitude completeness Mc, b-value and a-value are being estimated. It has observed that the overall b-value in and around Bangladesh is of 0.84 which is seemed to be seismically active zone. As, reliable b-value assessment can lead to better seismic hazard analysis, reliable magnitude of completeness Mc can lead to b-value assessment of an area, this work has dealt and estimated magnitude of completeness Mc using various techniques for the whole region for a reliable estimation. Estimated Mc is obtained to be around 3.9-4.7, which lead to b-value of 0.93. Spatial variations of Mc and b-value have been investigated for 1ox1o horizontal and vertical rectangular regions for the study area between 18-29°N and 84-95°E. Estimated Mc and b-value along with b-value are then averaged for the common regions in the pair of horizontal and vertical regions. Results are then being presented in the form of maps. The findings resemble as, the Mc is low at the border line of N-W Bangladesh, and a line from Cox’s bazaar to Sylhet through Hill tracts. Remain parts belong to the Mc value of 4.1-4.2, thus the b-value obtained is varying from 0.68 to 1.2, where, the value is higher at region in Chittagong and Barisal division that extends toward north through part of Dhaka to Sylhet and lower at Rajshahi, Rangpur and part of Khulna division, while a-value is varying from 5.0 to 7.2 mostly from west to east.ReferencesAbercrombie R.E., and Brune J.N., 1994. Evidence for a constant b-value above magnitude 0 in the southern San Andreas, San Jacinto, and San Miguel fault zones and at the Long Valley caldera, California. Geophys. Res. Lett., 21(15), 1647-1650.Aki K., 1965. 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Temporal and spatial variations in the magnitude of completeness for homogenized moment magnitude catalogue for northeast India. J. Earth Syst. Sci., 121(1), 19-28.Felzer K.R., 2008. Simulated aftershock sequences for a M 7.8 earthquake on the southern San Andreas fault. Seismol. Res. Lett., 80, 21-25.GSB, 2018. Seismic Zone Map of Bangladesh. http://gsb.portal.gov.bd/sites/default/files/files/gsb.portal.gov.bd/common_document/a6e75ad2_5acd_4fe3_911d_c9d25a7e349e/BD_Sciesmic-zonemap(NBC).pdf, retrieved on 31 March 2018.Gutenberg B., and Richter C.F., 1944. Frequency of earthquakes in California, Bull. Seismol. Soc. Am., 34, 184-188.Gutenberg B., and Richter C.F., 1956. Earthquake magnitude, intensity, energy and acceleration (second paper). Bull. Seismol Soc. Am., 46(2), 105-145.Hafiez H.E.A., 2015. Estimating the magnitude of completeness for assessing the quality of earthquake catalogue of the ENSN. Egypt. Arab J. Geosci., 8(1), 9315-9323. 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Earthquake Hazards Program. https://earthquake.usgs.gov/earthquakes/search/, USA, retrieved on 20 April 2017.Utsu T., 1999. Representation and analysis of the earthquake size distribution: a historical review and some new approaches. Pure Appl. Geophys., 155(2), 509-535.Wiemer S., and Wyss M., 2000. Minimum magnitude of complete reporting in earthquake catalogs: examples from Alaska, the western United States, and Japan. Bull. Seismol. Soc. Am., 90, 859-869. Doi:10.1785/0119990114.Woessner J., and Wiemer S., 2005. Assessing the quality of earthquake catalogues: Estimating the magnitude of completeness and its uncertainty. Bull. Seismol. Soc. Am., 95(2), 684-698. Doi:10.1785/012040007.Wyss M., Hasegawa A., Wiemer S., and Umino N., 1999. Quantitative mapping of precursory seismic quiescence before the 1989, M7.1 off-Sanriku earthquake, Japan. Annali Di Geoflsica, 42(5), 851-869.Zuniga F.R., and Wyss M., 1995. 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ABSTRACT: The existence of donation-based crowdfunding as an alternative fundraising system in Indonesia has a great opportunity to keep growing. The millennials as a digitally-native generation should actively contribute to the development of donation-based crowdfunding. This study tries to identify the effect of the variables of performance expectancy, effort expectancy, social influence, facilitating conditions, sense of trust, and experience expectation on the intention to donate donation-based crowdfunding by the Muslim millennials in Indonesia. Respondents who were analyzed were 156 people who were selected using purposive sampling and tested using SmartPLS. The results showed that Social Influence, Sense of Trust, and Experience Expectation had a positive influence on Intention to donate to donation-based crowdfunding. However, a test of Performance Expectancy, Effort Expectancy, and Facilitating Conditions shows that there are different findings. The data presented in this study is expected to add new perspectives for relevant stakeholders to develop donation-based crowdfunding in Indonesia. Keywords: Donation-based Crowdfunding, Moslem Millennials, Partial Least Square, Donation. ABSTRAK: Kehadiran donation-based crowdfunding sebagai alternatif sistem penggalangan dana di Indonesia memiliki peluang yang besar untuk terus berkembang. Generasi milenial sebagai generasi yang terbiasa dengan teknologi seyogyanya berperan aktif dalam perkembangan platform donation-based crowdfunding. Penelitian ini bertujuan untuk mengidentifikasi pengaruh variabel performance expectancy, effort expectancy, social influence, facilitating conditions, sense of trust serta experience expectation terhadap intention to donate to donation-based crowdfunding dari para generasi milenial muslim di Indonesia. Responden yang dianalisis sejumlah 156 orang yang dipilih menggunakan teknik purposive sampling serta diuji menggunakan SmartPLS. Hasil penelitian menunjukkan Social Influence, Sense of Trust, dan Experience Expectation memiliki pengaruh positif terhadap Intention to donate to donation-based crowdfunding. Namun, pengujian pada Performance Expectancy, Effort Expectancy, dan Facilitating Conditions menunjukkan hasil yang berbeda. Data yang ditampilkan dalam penelitian ini diharapkan menambah sudut pandang baru bagi stakeholder terkait agar dapat mengembangkan donation-based crowdfunding di Indonesia. Kata Kunci: Donation-based Crowdfunding, Generasi Milenial Muslim, Partial Least Square, Donasi. DAFTAR PUSTAKA Achmad, R. W., Poluakan, M. V., Dikayuana, D., Wibowo, H., & Raharjo, S. T. (2019). Potret generasi milenial pada era revolusi industri 4.0. Focus: Jurnal Pekerjaan Sosial, 2(2), 187-197. doi:10.24198/focus.v2i2.26241 Ajzen, I. (1991). The theory of planned behavior. Organizational Behavior and Human Decision Processes, 50, 179-211. doi:10.1016/0749-5978(91)90020-t Ardiansyah, D. O. (2016). 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An empirical study of intentions to donate through social crowdfunding using the UTAUT model. Proceedings of the 1st Conference on Islamic Finance and Technology, CIFET, 21 September, Sidoarjo, East Java, Indonesia. doi:10.4108/eai.21-9-2019.2293953 Gerber, E. M., Hui, J. S., & Kuo, P. Y. (2012). Crowdfunding: Why people are motivated to post and fund projects on crowdfunding platforms. Retrieved from https://www.researchgate.net/publication/261359489 Ghozali, I. (2021). Partial Least Squares: Konsep, Teknik dan Aplikasi Menggunakan Program SmartPLS 3.2.9 untuk Penelitian Empiris Jilid 3. Semarang: Badan Penerbit Universitas Diponegoro. Gopay. (2020). Gopay Digital Donation Outlook 2020. Hidayatullah, S., Waris, A., Devianti, R. C., Sari, S. R., Wibowo, I. A., & Made, P. (2018). Perilaku generasi milenial dalam menggunakan aplikasi go-food. Jurnal Manajemen dan Kewirausahaan, 6(2), 240-249. doi:10.26905/jmdk.v6i2.2560 Hossain, M., & Oparaocha, G. O. (2017). 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ABSTRAK Pengelolaan pembangunan desa islami adalah konsep pembangunan desa yang memiliki karakteristik tercapainya tujuan pembangunan sosial ekonomi yang berdimensi holistik, seimbang antara aspek material dan spiritual. Penelitian ini bertujuan untuk mengkaji pembahasan kajian-kajian terdahulu secara sistematis tentang konsep dan praktik pengelolaan pembangunan desa dalam perspektif islam. Dalam rangka melakukan review publikasi artikel secara sistematis, riset ini menggunakan standar protokol RAMESES. Hasil penelitian ini terbagi menjadi dua tema utama, yaitu peran dan fungsi lembaga keuangan mikro syariah dalam pembangunan desa dan Lembaga Swadaya Masyarakat dalam pengelolaan pembangunan desa. Tema pertama menghasilkan tiga subtema: praksis keuangan mikro syariah di Bangladesh, Malaysia, dan Indonesia. Tema kedua menghasilkan satu subtema yaitu peranan Pesantren dalam mendukung pengelolaan pembangunan desa. Hasilnya memberikan landasan untuk mengisi ruang-ruang yang belum dimasuki untuk membangun pengelolaan pembangunan desa yang komprehensif berdasarkan prinsip atau nilai Islam yang ideal. Kata kunci: Islami, Pengelolaan Pembangunan Desa, Systematic Literature Review. ABSTRACT Islamic village development management is a village development concept that has the characteristics of achieving socio-economic development goals with a holistic dimension, balanced between material and spiritual aspects. This study aims to systematically review the discussion of previous studies on the concepts and practices of village development management from an Islamic perspective. To conduct the article review systematically, this research was carried out using the RAMESES protocol standard. The results of this study are divided into two main themes, namely the role and function of Islamic microfinance institutions in village development and non-governmental organizations in managing village development. The first theme produces three sub-themes: the practice of Islamic microfinance in Bangladesh, Malaysia, and Indonesia. The second theme resulted in a sub-theme, namely Pesantren's role in supporting the management of village development. The results provide a foundation to fill in the gaps that have not been entered to build a comprehensive village development management based on ideal Islamic principles or values. Keywords: Islamic, Village Development Management, Systematic Literature Review. REFERENCES Abdullah, M. F., Amin, M. R., & Ab Rahman, A. (2017). Is there any difference between Islamic and conventional microfinance? Evidence from Bangladesh. International Journal of Business and Society, 18(S1), 97–112. Adejoke, A.-U. G. (2010). Sustainable microfinance institutions for poverty reduction: Malaysian experience. OIDA International Journal of Sustainable Development, 2(4), 47–56. http://dx.doi.org/10.2139/ssrn.1666023 Akhter, W., Akhtar, N., & Jaffri, S. K. A. (2009). 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ABSTRACT One of the contributions of the Islamic banking sector to Indonesia’s economy is channeling funds to MSMEs in the form of financing since a number of them could not access financial services. Interestingly, the MSMEs grew as the Islamic Banking sector rose. However, no single study analyzes such an impact on unemployment in both rural and urban areas. This paper aimed to reveal the effect of MSMEs financing in Islamic banks on unemployment in Indonesia. It further aimed to discover such an effect on unemployment in Indonesia's urban and rural areas separately. Dynamic panel GMM two-step analysis is used in this research to estimate cross-province data in Indonesia between 2010 and 2019. The results of the study reveal that MSMEs financing in Islamic Banks contributed significantly to the reduction of unemployment in Indonesia as a whole. It is also found that the unemployment in urban areas is reduced by MSMEs financing in Islamic Banks. On the other hand, there is no significant relationship between MSMEs financing in Islamic Banks and unemployment in rural areas. These findings can be the basis for Islamic banks to increase MSMEs financing and for the government to expand Islamic banks' role in every part of Indonesia to reduce unemployment, especially in rural areas. Keywords: MSMEs Financing, Islamic Bank, Unemployment, Urban, Rural. ABSTRAK Salah satu kontribusi sektor perbankan syariah dalam perekonomian Indonesia adalah penyaluran dana kepada UMKM dalam bentuk pembiayaan, karena beberapa dari mereka tidak dapat mengakses layanan keuangan. Menariknya, UMKM tumbuh seiring dengan bangkitnya sektor Perbankan Syariah. Namun, tidak ada satu studi pun yang menganalisis dampak tersebut terhadap pengangguran di pedesaan dan perkotaan. Penelitian ini bertujuan untuk mengungkap pengaruh pembiayaan UMKM di bank syariah terhadap pengangguran di Indonesia. Hal ini bertujuan untuk mengetahui lebih jauh pengaruh tersebut terhadap pengangguran di daerah perkotaan dan pedesaan secara terpisah di Indonesia. Analisis dua langkah GMM panel dinamis digunakan untuk mengestimasi data lintas provinsi di Indonesia antara tahun 2010 dan 2019. Hasilnya mengungkapkan bahwa pembiayaan UMKM di Bank Syariah berkontribusi signifikan terhadap pengurangan pengangguran di Indonesia secara keseluruhan. Ditemukan juga bahwa pengangguran di perkotaan berkurang dengan pembiayaan UMKM di Bank Syariah. Di sisi lain, tidak ada hubungan yang signifikan antara pembiayaan UMKM di bank syariah dengan pengangguran di pedesaan. Hasil penelitian ini dapat menjadi dasar bagi bank-bank syariah dalam meningkatkan porsi pembiayaan UMKM dan dasar bagi pemerintah untuk memperluas peran perbankan syariah di seluruh bagian Indonesia untuk mengurangi pengangguran, khususnya di area pedesaan. Kata Kunci: Pembiayaan UMKM, Bank Syariah, Pengangguran, Perkotaan, Pedesaan. 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The World Trade Center Attack or 9/11 tragedy has awakened the international community, particularly the United States (US) to sharpen its foreign policy in facing security threats coming from ‘weak states’. One of the most prominent weak states examples that pose a grave threat to other countries are the Northern Triangle Countries of Central America that referred to Guatemala, Honduras, and El Salvador. Hence, this paper will discuss the rationale behind US initiatives in dealing with security threats in El Salvador as one of the Northern Triangle Countries. In analyzing the case, the writers will use the weak state concept and national interest concept. The result of this paper finds that El Salvador corresponds to the elements of a weak state and further poses security threats by giving rise to transnational criminal organizations, drug trafficking, and migrant problems in which overcoming those security threats has become US vital national interest. However, we also find that although decreasing security threats and strengthening El Salvador government capacity is highly correlated, strengthening El Salvador governance through the providence of aid and assistance is actually classified as US important national interest. Keywords: Security threats; Northern Triangle; weak state; El Salvador; national interest REFERENCES Ambrus, Steven. “Guatemala: The Crisis of Rule of Law and a Weak Party System.” Ideas Matter, January 28, 2019. https://blogs.iadb.org/ideas-matter/en/guatemala-the-crisis-of-rule-of-law-and-a-weak-party-system/. Andrade, Laura. Transparency In El Salvador. 1st ed. 1. El Salvador: University Institute for Public Opinion, Asmann, Parker. “El Salvador Citizens Say Gangs, Not Government 'Rule' the Country.” InSight Crime, August 19, 2020. https://insightcrime.org/news/brief/el-salvador-citizens-say-gangs-not- government-rules-country/. Accessed July 11, 2021. Art, Robert J. A. Grand Strategy for America. 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Teacher's abilities to understand the benefits and use of media literacy play an important role in dealing with children as digital natives. Media literacy education can be an instrument through the use of blended-learning websites to address the challenges of education in the 21st century and learning solutions during and after the Covid-19 pandemic. This study aims to figure the teacher's perspective in understanding media literacy as an instrument for implementing blended-learning in early-childhood classes. Using a qualitative approach, this study combines two types of data. Data collection involved kindergarten teachers, six people as informants who attended the interviews and twenty-six participants who filled out questionnaires. Typological data analysis was used for qualitative data as well as simple statistical analysis to calculate the percentage of teacher perspectives on questionnaires collected the pandemic. The findings show five categories from the teacher's perspective. First, about the ability to carry out website-based blended-learning and the use of technology in classrooms and distance learning is still low. It must be transformed into more creative and innovative one. Encouraging teacher awareness of the importance of media literacy education for teachers as a more effective integrated learning approach, especially in rural or remote areas, to be the second finding. Third, national action is needed to change from traditional to blended-learning culture. Fourth, the high need for strong environmental support, such as related-party policies and competency training is the most important finding in this study. Finally, the need for an increase in the ease of access to technology use from all related parties, because the biggest impact of the Covid-19 pandemic is on ECE, which is closely related to the perspective of teachers on technology. 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Parents play an important role in the development of their children. This research reflects the role of parents in developing children. Through four stages of identification, screening, eligibility, and acceptable results, this method uses a systematic literature review using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) method. The findings from the fourteen articles examined show that parenting skills play an important role in a child's growth and development from birth to death. The determining factor in the development of physical, motoric, moral, language, social-emotional, and life skills aspects is the role of both parents as important teachers for children from birth to adulthood. Parents can also use a variety of parenting strategies and skills, many of which they have learned throughout their lives and passed on to their children, to help their children grow. 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