Teses / dissertações sobre o tema "Genetic of cancer"
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Veja os 50 melhores trabalhos (teses / dissertações) para estudos sobre o assunto "Genetic of cancer".
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Michael, Agnieszka. "Genetic immunotherapy for cancer". Thesis, St George's, University of London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.437318.
Texto completo da fonteSingh, Rashmi. "Genetic predisposition to prostate cancer". Thesis, Institute of Cancer Research (University Of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.416575.
Texto completo da fonteSkoglund, Johanna. "Genetic studies of colorectal cancer /". Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-098-5/.
Texto completo da fonteWiklund, Fredrik. "Genetic epidemiology of prostate cancer". Doctoral thesis, Umeå : Univ, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-281.
Texto completo da fonteLutke, Holzik Martijn Frederik. "Genetic predisposition to testicular cancer". [S.l. : [Groningen : s.n.] ; University Library Groningen] [Host], 2007. http://irs.ub.rug.nl/ppn/304254797.
Texto completo da fonteGonzález-Zuloeta, Ladd Angela Maria. "Genetic determinants of breast cancer". [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2007. http://hdl.handle.net/1765/10525.
Texto completo da fonte黎子韻 e Tsz-wan Kristi Lai. "Genetic polymorphisms in ovarian cancer". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B31970618.
Texto completo da fonteCheung, Chin-ling, e 張展寧. "Genetic analysis of nasopharyngeal cancer". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B44659866.
Texto completo da fonteCheng, Timothy. "Genetic susceptibility to endometrial cancer". Thesis, University of Oxford, 2015. http://ora.ox.ac.uk/objects/uuid:3a559ae0-156f-48a2-a64e-b03a13c562df.
Texto completo da fonteLai, Tsz-wan Kristi. "Genetic polymorphisms in ovarian cancer". Hong Kong : University of Hong Kong, 2002. http://sunzi.lib.hku.hk/hkuto/record.jsp?B25176493.
Texto completo da fonteKho, Pik Fang. "Genetic epidemiology of endometrial cancer". Thesis, Queensland University of Technology, 2021. https://eprints.qut.edu.au/211383/1/Pik%20Fang_Kho_Thesis.pdf.
Texto completo da fonteSotheran, Wendy. "Genetic predisposition to breast cancer in selected individuals in Guernsey". Thesis, University of Southampton, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264721.
Texto completo da fonteTai, Lai-shan, e 戴麗珊. "Molecular genetic characterizations of human non-small cell lung cancer". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B31375315.
Texto completo da fonteMarsh, Howard Piers. "Genetic polymorphisms in bladder cancer angiogenesis". Thesis, University of Bristol, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.428513.
Texto completo da fonteQuan, Xiaojiang. "Genetic study of mammary cancer development". Doctoral thesis, Universite Libre de Bruxelles, 2001. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/211503.
Texto completo da fonteZhou, ZiaoLei. "Molecular genetic studies of colorectal cancer /". Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-489-9/.
Texto completo da fonteHasmats, Johanna. "Analysis of genetic variations in cancer". Doctoral thesis, KTH, Genteknologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-104438.
Texto completo da fonteQC 20121105
Ilyas, Mohammad. "The genetic basis of colorectal cancer". Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301849.
Texto completo da fonteLubbe, Steven John. "The genetic epidemiology of colorectal cancer". Thesis, Institute of Cancer Research (University Of London), 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.538696.
Texto completo da fonteLancaster, Johnathan Mark. "Molecular genetic etiology of ovarian cancer". Thesis, Cardiff University, 2005. http://orca.cf.ac.uk/55576/.
Texto completo da fonteReles, Angela. "Molecular genetic alterations in ovarian cancer". Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2001. http://dx.doi.org/10.18452/13801.
Texto completo da fonteObjective: The p53 tumor suppressor gene plays a central role in cell cycle regulation and induction of apoptosis. MDM2, the protein of the mdm2 gene, binds to p53, inhibits its transcriptional activity and promotes nuclear export and rapid degradation of the p53 protein. Methods: Frozen tissue of 178 ovarian carcinomas was analyzed for mutations of the p53 gene (exons 2-11) and p53 overexpression by SSCP (Single Strand Conformation Polymorphism), DNA-sequencing and immunohistochemistry. 92 cases of ovarian cancer, nine borderline ovarian tumors, six cystadenomas and 20 normal ovarian tissues were analyzed for mdm2 alternative RNA splicing by reverse transcription of total RNA, nested PCR amplification of mdm2 cDNAs and DNA sequencing of RT-PCR products. Results: p53 mutations were found in 56% (99/178) and p53 protein overexpression in 62% (110/178) of the tumors. Time to progression and overall survival were significantly shortened in patients with p53 mutations compared to wildtype p53 (p=0.029 and p=0.014). Resistance to adjuvant Cis- or Carboplatin chemotherapy was significantly more frequent in patients with p53 overexpression (p=0.001) or p53 missense mutations (p=0.008) than patients with normal p53. mdm2 RNA splicing was seen in 66/92 (72%) of the ovarian carcinomas, 7/9 (78%) of borderline tumors, 5/6 (83%) of benign cystadenomas and 11/20 (55%) of the normal ovarian tissues. A total of 30 splice variant sequences were identified, out of which 22 had a partial or complete loss of the p53 binding site. 28/30 do not splice at exon/intron boundaries and were therefore considered aberrant splice variants. The mdm2b splice variant of 654 bp, which splices out most of the p53 binding domain, was expressed in 41% of ovarian carcinomas, but only in 1/9 (11%) LMP tumors, and 1/20 (5%) of the normal ovaries. Expression of mdm2b in ovarian carcinomas was significantly correlated with poor grade of differentiation (p=0.004), residual tumor after surgery (p=0.004), high S-phase fraction (p=0.016) and p53 protein overexpression (p=0.018). A small splice variant of only 221 bp was present in only 16% of the ovarian carcinomas, but 56% of borderline tumors, and 40% of normal ovarian tissues and was correlated with early stage of ovarian cancer (p=0.017) and longer overall survival (p=0.048). Conclusion: p53 alterations correlate significantly with resistance to platinum-based chemotherapy, early relapse and shortened overall survival in ovarian cancer patients in univariate analysis. In multivariable analysis though, p53 was not an independent prognostic factor. mdm2 alternative and aberrant splicing was found frequently in ovarian tumors but also in normal ovarian tissue. While expression of the mdm2b splice variant was associated with histologically more aggressive ovarian carcinomas, smaller size variants were typically seen in early stage ovarian carcinomas and benign tissues. mdm2 alterations may stabilize p53 protein and cause p53 accumulation in the absence of p53 mutation in ovarian tumors.
Hayat, Roshanai Afsaneh. "Psychological and Behavioral Aspects of Receiving Genetic Counseling for Hereditary Cancer". Doctoral thesis, Uppsala universitet, Vårdvetenskap, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-128870.
Texto completo da fonteChen, Lina. "Genetic epidemiology of Prostate Cancer : a genetic approach to identifying casual modifiable risk factors for prostate cancer". Thesis, University of Bristol, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627980.
Texto completo da fonteUpstill-Goddard, Rosanna. "Genetic dissection of early-onset breast cancer and other genetic diseases". Thesis, University of Southampton, 2015. https://eprints.soton.ac.uk/386938/.
Texto completo da fonte陳安安 e On-on Annie Chan. "Methylation in colorectal cancer". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B25256312.
Texto completo da fonteDjureinovic, Tatjana. "Investigation of genetic factors involved in colorectal cancer predisposition /". Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-864-9/.
Texto completo da fonteYoung, Alison Luk. "Next generation communication about hereditary cancer". Thesis, The University of Sydney, 2019. http://hdl.handle.net/2123/20973.
Texto completo da fonteWright, C. M. "The prognostic significance of microsatellite instability in sporadic stage C colorectal cancer". Thesis, The University of Sydney, 2008. https://hdl.handle.net/2123/28955.
Texto completo da fonte陳潔盈 e Kit-ying Loucia Chan. "Expression analysis of Candidate cancer genes in non-small cell lung cancer". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B45011163.
Texto completo da fonteHussien, M. "Folate status, genetic damage and breast cancer". Thesis, Queen's University Belfast, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269044.
Texto completo da fonteAshton, Kevin John, e K. Ashton@griffith edu au. "Genetic Aberrations in Non-Melanoma Skin Cancer". Griffith University. School of Health Science, 2002. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20030818.122305.
Texto completo da fonteGentile, Massimiliano. "Genetic alterations in early onset breast cancer /". Linköping : Univ, 2001. http://www.bibl.liu.se/liupubl/disp/disp2001/med686s.pdf.
Texto completo da fonteValdman, Alexander. "Molecular genetic markers of prostate cancer development /". Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-618-9/.
Texto completo da fonteWedrén, Sara. "Genetic susceptibility to breast and endometrial cancer /". Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-053-2/.
Texto completo da fonteFransén, Karin. "Molecular genetic aspects of colorectal cancer development /". Linköping : Univ, 2005. http://www.bibl.liu.se/liupubl/disp/disp2005/med878s.pdf.
Texto completo da fonteSalahshor, Sima. "Different genetic pathways involved in colorectal cancer /". Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4690-6/.
Texto completo da fonteLake, Sarah Louise. "Genetic analysis of LPHH1 in lung cancer". Thesis, University of Liverpool, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404506.
Texto completo da fonteSteggles, Naomi. "Psychological aspects of genetic testing for cancer". Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271020.
Texto completo da fonteFord, Deborah. "Genetic epidemiology of breast and ovarian cancer". Thesis, Institute of Cancer Research (University Of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367527.
Texto completo da fonteBabalghith, Ahmad Omar. "Genetic events involved in bladder cancer progression". Thesis, University of Aberdeen, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.445140.
Texto completo da fonteVessey, Carina Jayne. "Genetic predisposition to genomic instability in cancer". Thesis, Open University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.262690.
Texto completo da fonteSmith, Joel Anthony. "Molecular genetic investigation of medullary thyroid cancer". Thesis, University of Birmingham, 2015. http://etheses.bham.ac.uk//id/eprint/6314/.
Texto completo da fonteBolton, Kelly. "The genetic epidemiology of ovarian cancer survival". Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610071.
Texto completo da fonteMackay, James. "Molecular genetic studies in human breast cancer". Thesis, University of Edinburgh, 1989. http://hdl.handle.net/1842/19076.
Texto completo da fonteJohns, Neil. "Phenotypes and genetic markers of cancer cachexia". Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/23392.
Texto completo da fonteLam, Man-Yee Josephine. "Genetic Control of Susceptibility to Testicular Cancer". Case Western Reserve University School of Graduate Studies / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=case1112676217.
Texto completo da fonteAllan, Lindsey A. "The molecular genetic events of ovarian cancer". Thesis, University of Aberdeen, 1994. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU068634.
Texto completo da fonteKim, Eejung. "Functional characterization of genetic alterations in cancer". Thesis, Harvard University, 2016. http://nrs.harvard.edu/urn-3:HUL.InstRepos:33493591.
Texto completo da fonteMedical Sciences
Adams, David James. "The Genetic and Therapeutic Landscape of Cancer". Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/29490.
Texto completo da fonteAshton, Kevin John. "Genetic Aberrations in Non-Melanoma Skin Cancer". Thesis, Griffith University, 2002. http://hdl.handle.net/10072/367012.
Texto completo da fonteThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Health Sciences
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