Bibliografias temáticas / Experimental medicine

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Literatura científica selecionada sobre o tema "Experimental medicine"

Autor: Grafiati

Publicado: 4 de junho de 2021

Última modificação: 29 de julho de 2024

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Artigos de revistas sobre o assunto "Experimental medicine"

Ottaviani, Palma T. "Physiology and Experimental Medicine". Pediatric Drugs 11, n.º 1 (2009): 69–71. http://dx.doi.org/10.2165/0148581-200911010-00023.

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Dawson, Gerard R., e Guy Goodwin. "Experimental medicine in psychiatry". Journal of Psychopharmacology 19, n.º 6 (novembro de 2005): 565–66. http://dx.doi.org/10.1177/0269881105059935.

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Park, Jang-Kyung, e Dong-Il Kim. "Modernization Trends of Infertility Treatment of Traditional Korean Medicine". Evidence-Based Complementary and Alternative Medicine 2017 (2017): 1–9. http://dx.doi.org/10.1155/2017/4835912.

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Despite the development of assisted reproductive technology (ART), it is difficult to increase the implantation rate. In Korea, Traditional Korean Medicine, including herbal medicine, is an important component of infertility treatment. Korean medical doctors who are treating infertility often use herbal medicine to promote implantation. In this article, as one of the research works on modernization of Traditional Korean Medicine, we investigated the experimental studies to clarify the effects of herbal medicines that are traditionally used to promote pregnancy. We searched for experimental studies over the past 10 years of improvement of endometrial receptivity in herbal medicine using six domestic and international sites. We analyzed 11 studies that meet the selection criteria. We found that herbal medicines demonstrably improved endometrial receptivity and increased pregnancy rates.

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Lavelle, Séan M. "Suggested curriculum for experimental medicine". Technology and Health Care 20, n.º 3 (25 de junho de 2012): 237–38. http://dx.doi.org/10.3233/thc-2012-0666.

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Abdel-Halim, RabieE. "Experimental medicine 1000 years ago". Urology Annals 3, n.º 2 (2011): 55. http://dx.doi.org/10.4103/0974-7796.82168.

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Keith, Ronald Mac. "THE CHILD AND EXPERIMENTAL MEDICINE". Developmental Medicine & Child Neurology 6, n.º 3 (12 de novembro de 2008): 229–30. http://dx.doi.org/10.1111/j.1469-8749.1964.tb10781.x.

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Romano, G. "Gene transfer in experimental medicine". Drug News & Perspectives 16, n.º 5 (2003): 267. http://dx.doi.org/10.1358/dnp.2003.16.5.829314.

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Insel, Thomas R. "The NIMH experimental medicine initiative". World Psychiatry 14, n.º 2 (junho de 2015): 151–53. http://dx.doi.org/10.1002/wps.20227.

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Bellavite, Paolo, Riccardo Ortolani e Anita Conforti. "Immunology and Homeopathy. 3. Experimental Studies on Animal Models". Evidence-Based Complementary and Alternative Medicine 3, n.º 2 (2006): 171–86. http://dx.doi.org/10.1093/ecam/nel016.

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A search of the literature and the experiments carried out by the authors of this review show that there are a number of animal models where the effect of homeopathic dilutions or the principles of homeopathic medicine have been tested. The results relate to the immunostimulation by ultralow doses of antigens, the immunological models of the ‘simile’, the regulation of acute or chronic inflammatory processes and the use of homeopathic medicines in farming. The models utilized by different research groups are extremely etherogeneous and differ as the test medicines, the dilutions and the outcomes are concerned. Some experimental lines, particularly those utilizing mice models of immunomodulation and anti-inflammatory effects of homeopathic complex formulations, give support to a real effect of homeopathic high dilutions in animals, but often these data are of preliminary nature and have not been independently replicated. The evidence emerging from animal models is supporting the traditional ‘simile’ rule, according to which ultralow doses of compounds, that in high doses are pathogenic, may have paradoxically a protective or curative effect. Despite a few encouraging observational studies, the effectiveness of the homeopathic prevention or therapy of infections in veterinary medicine is not sufficiently supported by randomized and controlled trials.

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Bellanti, Francesco, Gianluigi Vendemiale e Gaetano Serviddio. "Redox experimental medicine and liver regeneration". Redox Experimental Medicine 2022, n.º 1 (1 de julho de 2022): R69—R82. http://dx.doi.org/10.1530/rem-22-0008.

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The liver is characterized by unique regenerative properties to restore its mass and function after a partial loss. Hepatic regeneration arises after resection or following acute and chronic injuries. Resection and acute liver damage normally induce a regenerative process characterized by phenotypic fidelity, in which each cell type promotes its own replication and replacement. This process fails in chronic liver damage, where trans-differentiation of parenchymal cells or activation of facultative progenitors occurs. Both liver resection and acute/chronic damages alter redox homeostasis, as a consequence of blood flow changes, hypoxia, metabolism modification, and activation of inflammatory response. Even though formerly described as ‘oxidative stress’, altered redox homeostasis leads to the fine regulation of several pathways involved in liver regeneration, including the proliferation of parenchymal cells, trans-differentiation, and activation of facultative progenitors. Several redox-dependent transcription factors and pathways implicated in the regenerative process of the liver were described, but pre-clinical experiments using different antioxidants were not fully conclusive. Even though accurate study designs to define appropriate dosages, treatment duration, and routes of administration are required, modulation of redox-dependent molecular pathways to enhance liver regeneration is even more intriguing. Preliminary studies focused on the identification of these targets will pave the way for viable therapies to be tested in clinical trials.

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Teses / dissertações sobre o assunto "Experimental medicine"

Strickland, Thomas. "Experimental spaces: megastructures, medicine and McMaster". Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=110431.

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This thesis is an architectural study that focuses on an anxious and exciting period for medicine and architecture between 1960 and 1975. This time was an important moment of adjustment and adaptation for medicine, architecture and community. Collateral to the establishment of national health insurance (Medicare, 1966), architects and hospital planners sought to use the space of the hospital to foster this new relationship with their constituency. This happened in multiple and surprising ways, from the introduction of public spaces in hospitals, to a medical exhibit at Expo 67 that was as much an amusement ride as it was a didactic space, to a significant reorganization of the socio-spatial hierarchy of the hospital - all of which foreshadowed the influential atrium hospital of the 1980s and its shopping mall-like setting. The primary focus of this thesis is a building that Reyner Banham touted as the "ultimate medical megastructure" (1976), the McMaster Health Sciences Centre (1972) designed by the Toronto firm of Craig, Zeidler and Strong Architects. At the core of this study is the belief that hospital architecture is influenced by medical ambitions, but also architectural discourse and social dynamics. Based on this understanding, the analysis examines how the social ambitions of the Megastructuralist polemic interacted with the powerful urge to assimilate biological research activities with the clinical setting. Archival resources, interviews and a broad range of architectural precedents are presented and analyzed to understand the medical and architectural trends that contributed to McMaster Health Sciences Centre's innovative and influential design. In this thesis, megastructuralist experimental, utopian projects and, importantly, the broader debate over the future of the postwar city is brought to bear on biomedical ambitions and the architecture of the hospital.
D'un point de vue architectural, cette thèse s'intéresse à la relation qui émerge entre médecine, architecture et communauté dans les années 1960 à 1975 : période charnière d'ajustement et d'adaptation. Parallèlement à la création des organismes nationaux d'assurance maladie (Medicare, 1966), les architectes et les planificateurs des hôpitaux ont cherché à utiliser l'espace même de l'hôpital pour favoriser de nouvelles relations auprès de la collectivité. Cette approche est apparue de multiples manières et, parfois même, de façon surprenante ; pensons à l'introduction des espaces publics dans les hôpitaux, à une exposition sur la médecine présentée à Expo'67 qui s'apparentait autant à une attraction publique qu'à un espace didactique, ou encore à l'importante réorganisation de la hiérarchie socio-spatiale des hôpitaux. Tous ces éléments préfiguraient l'influence et la prégnance de l'atrium, et de ses espaces commerciaux, dans les hôpitaux des années 1980. La thèse examinera plus précisément le Centre des sciences de la santé de l'Université McMaster (MHSC) de Hamilton, conçu par la firme d'architectes Craig, Zeidler & Strong, que Reyner Banham décrit comme l'ultime mégastructure médicale (1976). Sur les bases du discours architectural, de la dynamique sociale et, surtout, d'une profonde conviction que la production de l'architecture hospitalière est influencée par certaines visées médicales, cette analyse portera sur la façon dont les ambitions sociales de la polémique mégastructuraliste interagissent avec l'assimilation des activités de recherche biologique au sein des installations cliniques. Diverses ressources, telles que des archives, des entrevues et un large éventail de précédents, seront décrites, utilisées et analysées afin de cerner les tendances médicales et architecturales qui ont contribué à la conception, innovante et influente, du Centre des sciences de la santé de l'Université McMaster. Le mégastructuralisme expérimental, les projets utopiques ainsi que le débat plus large sur l'avenir de la ville d'après-guerre permettront à la thèse de porter un regard nouveau sur les ambitions biomédicales et architecturales dans les hôpitaux.

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Olofsson, Pia. "Experimental studies on Damage Control Surgery and Intraabdominal Hypertension". Doctoral thesis, Linköpings universitet, Kirurgi, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-17796.

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Damage control surgery (DCS) offers an alternative to the traditional surgical management of complex or multiple injuries in critically injured patients. If a patient survives the initial phase of DCS, complications may occur, one of these being intraabdominal hypertension (IAH) and it´s potential development into the abdominal compartment syndrome. The indications for DCS have been widened and DCS principles can be applied in situations where time and resources are essential factors. The DCS principles of rapidly controlling intestinal spillage have not been evaluated. The aim of the studies in Papers I and II was to evaluate the principles of spillage control of intestinal contents according to the DCS concept and more specifically the effects of early rapid control of multiple bowel perforations on cardiovascular and pulmonary function compared with conventional small bowel resections in an animal model with abdominal trauma. In Paper I the animal model using anaesthetised pigs included a gunshot wound to the abdomen which caused multiple small bowel injuries. Haemorrhagic shock was combined with the gunshot wound in Paper II. The results presented in Paper I showed a significant reduction in rise in systemic vascular resistance and pulmonary vascular resistance, and a trend towards higher cardiac output and lower oxygen consumption in the bowel ligation group. In Paper II the results show a longer persistence of lactic acidaemia in the bowel ligation group. The aim of the study in Paper III was to assess visceral (intestinal, gastric and renal) microcirculation parallel with central haemodynamics and respiratory function during stepwise increases in intraabdominal pressure. In Paper IV we studied mucosal barrier function and morphology in the small bowel and colon of the pigs which were subjected to IAH. The IAP in anaesthetised pigs was increased stepwise using CO2 inflation, by 10 mm Hg at 10-minute intervals up to 50 mm Hg, and followed by exsufflation (Paper III). The microcirculation was selectively studied using a 4-channel laser Doppler flowmeter (Periflex 5000, Perimed, Sweden). The mucosal tissues were mounted in modified Ussing chambers for assessment of barrier function (E.coli K12 uptake and 51Cr-EDTA permeability) (Paper IV). The results showed that the microcirculation of the small bowel mucosa and colon mucosa was significantly less affected compared to the seromuscular layers. The microcirculation of gastric mucosa, renal cortex and the seromuscular layer of small bowel and colon were significantly reduced with each increase. Cardiac output (CO) decreased significantly at IAP levels above 10 mm Hg and the respiratory function data showed an increasing airway pressure and a concomitant reduction in thoracic compliance. Transmucosal passage of E. coli was increased three-fold in the small bowel after ACS with a significant correlation to the degree of mucosal microcirculatory reperfusion after exsufflation. 51Cr-EDTA permeability was unaffected. Bacterial passage in the colon was unchanged, whereas 51Cr-EDTA permeability after ACS increased by up to 181% of baseline and was correlated to significant histopathological changes in the mucosa. In Paper I we have demonstrated that early rapid control of multiple bowel perforations in a model with moderate shock resulted in less impairment of SVR and PVR than conventional resection and anastomosis. The use of DCS principles, however, had no beneficial effect on cardiovascular function when haemorrhagic shock was combined with abdominal missile trauma (Paper II), on the contrary bowel ligation was followed by more prolonged lactic acidosis than conventional repair. The studies in Paper III and IV indicate that the microcirculation of intestinal mucosa and especially small bowel mucosa seem better preserved in response to intraabdominal hypertension caused by CO2 insufflation than other intraabdominal microvascular beds. The short term ACS in this model caused morphological changes in the intestinal mucosa, and mucosal barrier dysfunction. The response pattern concerning barrier function changes after CO2 insufflation differs between small bowel and colonic mucosa. The small bowel mucosa showed increased bacterial passage, and the colonic mucosa an increase in paracellular permeability and secretory response.

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Amandusson, Åsa. "Estrogen Receptor Expression in Relation to Pain Modulation and Transmission: Experimental Studies in Rats". Doctoral thesis, Linköpings universitet, Cellbiologi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-17978.

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Estrogens have a remarkably wide range of actions in the mammalian brain. They not only play a pivotal role in reproductive behavior and sexual differentiation, but also contribute to e.g. thermoregulation, feeding, memory, neuronal survival and the perception of somatosensory stimuli. A multitude of studies on both animals and human subjects has demonstrated potential effects of gonadal hormones, such as estrogens, on pain transmission. These effects most likely involve multiple neuroanatomical circuits as well as diverse neurochemical systems and therefore need to be evaluated specifically in relation to the localization and intrinsic characteristics of the neurons engaged. The overall aim of this thesis is to gain specific knowledge of the possible cellular mechanisms by which estrogens may influence the transmission of nociceptive stimuli at the level of the spinal cord. The estrogen receptors, by which estrogens regulate non-genomic as well as genomic mechanisms, are crucial to estrogen signaling in general and essential to the estrogen-induced effects in the brain. In Paper I, we use immunohistochemistry to label neurons containing estrogen receptor-! (ERα) in the medullary and spinal dorsal horn of female rats. Large numbers of ER!-expressing neurons were found in lamina I and lamina II, i.e. in the areas involved in the processing of primary afferent nociceptive information. This distribution in part overlaps that of enkephalin, a potent pain-inhibiting endogenous opioid. The effects of gonadal hormones on pain modulation may, to a great extent, be blocked by the opioid antagonist naloxone, suggesting an involvement of the endogenous opioid system in the prosecution of hormonal pain regulation. By combining immunohistochemical labeling of ERα with in situ hybridization of preproenkephalin mRNA (Paper II), we demonstrate that the majority of enkephalinergic neurons in the superficial laminae of the spinal and medullary dorsal horn express ER!. This co-localization and the fact that the preproenkephalin gene contains a sequence that binds ERs, suggest that estrogens may potentially regulate enkephalin expression in these cells. This is further supported by the findings in Paper III in which we show that a single subcutaneous injection of estradiol induces a significant increase (on average 68%) in preproenkephalin mRNA content in the spinal cord after 4 hours. The expression of the enkephalin gene in the spinal cord is thus sensitive to fluctuating estradiol levels. In Paper IV, a noxious injection of formalin is used to induce activation of a neuronal population involved in nociceptive transmission from the face. By using a dual-labeling immunohistochemistry protocol, we were able to identify ER!-expressing cells within this neuronal population suggesting that nociceptive-responsive neurons in the medullary dorsal horn express ER!. In all, our findings provide morphological as well as biochemical evidence in support for an estrogen-dependent modulation of nociceptive processing at the level of the dorsal horn.

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Samuelsson, Anders. "Effects of burns and vasoactive drugs on human skin : Clinical and Experimental studies using microdialysis". Doctoral thesis, Linköpings universitet, Anestesiologi med intensivvård, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-59519.

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Patients who require critical care, including those with burns, are affected by a systemic inflammatory reaction, which at times has consequences such as multiple organ dysfunction and failure. It has become increasingly evident that other factors important in the development of organ dysfunction are disturbances at the tissue level, in the microcirculation. Such disturbances activate cascade systems including stress hormones, all of which have local effects on organ function. Despite this knowledge, monitoring and treatment in critical illness today relies mainly on central haemodynamics and blood sampling. Microdialysis is a minimally invasive technique that enables us to study the chemical composition and changes in biochemistry in the extracellular, extravascular space in living tissues. Most of our current experience is from animal models, but the technique has also been used in humans and has become routine in many neurosurgical intensive care units to monitor brain biochemistry after severe injury. In skin, this experience is limited. During the first half of this thesis we studied the injured and uninjured skin of severely burned patients. The results show that there are severe local metabolic disturbances in both injured and uninjured skin. Most interesting is a sustained tissue acidosis, which is not detectable in systemic (blood) sampling. We also recorded considerable alterations in the glucose homeostasis locally in the skin, suggesting a cellular or mitochondrial dysfunction. In parallel, we noted increased tissue glycerol concentrations, which indicated appreciable traumainduced lipolysis. We also examined serotonin kinetics in the same group of patients, as serotonin has been claimed to be a key mediator of the vasoplegia and permeability disturbances found in patients with burns. We have shown, for the first time in humans to our knowledge, that concentrations of serotonin in skin are increased tenfold, whereas blood and urine concentrations are just above normal. The findings support the need for local monitoring of substances with rapid local reabsorption, or degradation, or both. The results also indicate that serotonin may be important for the systemic response that characterises burn injuries. In the second half of the thesis we evaluated the effects of microdosing in skin on metabolism and blood flow of vasoactive, mainly stress-response-related, drugs by the microdialysis system. The objectives were to isolate the local effects of the drugs to enable a better understanding of the complex relation between metabolic effects and effects induced by changes in local blood flow. In the first of these two studies we showed that by giving noradrenaline and nitroglycerine into the skin of healthy subjects we induced anticipated changes in skin metabolism and blood flow. The results suggest that the model may be used to examine vascular and metabolic effects induced locally by vasoactive compounds. Data from the last study indicate that conventional pharmacodynamic models (Emax) for time and dose response modelling may be successfully used to measure the vascular and metabolic response in this microdosing model. We conclude that the microdialysis technique can be successfully used to monitor skin metabolism and iso late a mediator (serotonin) of the local skin response in burned patients. It was also feasible to develop a vascular model in skin based on microdialysis to deliver vasoactive substances locally to the skin of healthy volunteers. This model provided a framework in which the metabolic effects of hypoperfusion and reperfusion in skin tissues could be examined further.

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Blakytny, Robert. "Experimental cataract and its prevention". Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.333181.

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Hillman, Nicola Jane. "Hypertension and experimental diabetic retinopathy". Thesis, University of Southampton, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241987.

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Hübbert, Laila. "Between the Probe and the Pump : An experimental study on cardiac performance analysis based on Echocardiography, tissue and laser Doppler". Doctoral thesis, Linköpings universitet, Kardiologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-61518.

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Echocardiography is an ultrasound-based bedside, non-invasive and easily available cardiac diagnostic technique visualising the heart’s morphology and function. Quantification of cardiac wall motion can be measured with the tissue Doppler Imaging (TDI) modality which provides in humans a high diagnostic capacity to differentiate healthy from diseased myocardium with reduced function. Heart failure, as a consequence of, for example, myocardial or ischaemic heart disease, demands both bedside and intraoperative diagnostic procedures for myocardial functional and perfusion assessment. In the late stages of heart failure cardiac left ventricular assist devices (LVAD) may be the treatment of choice. Such new technologies are commonly evaluated in large animals before application in humans is accepted. With the aim of evaluating TDI´s applicability and feasibility in a large animal model 21 calves (aged 3 months and weight around 70 kg), were studied with colour TDI (Paper I). Analysis was performed either during coronary artery occlusion when the laser Doppler perfusion imaging technique (LDMP) was refined (Paper II), or after implantation of the LVAD, Heart Mate II® (Papers III, IV). All animals were haemodynamically monitored (pressures, flows, heart rate) and ECG was continuously recorded. Transthoracic and epicardial echocardiography (TTE) were performed before and after sternotomy and intraoperatively during experimental progressive heart failure. Heart chamber dimensions, native stroke volume, systolic and diastolic regional basal myocardial peak velocities (cm/s; systolic S´, early diastolic E´, and atrial A´, strain (%), strain rate (s-1) and displacement (mm) were determined. Second harmonic imaging (SHI) was applied in order to better visualise air bubbles (Paper IV). In Paper I compiled baseline values were established before and after sternotomy for central haemodynamic and echocardiographic parameters, including the TDI myocardial motion variables velocity, strain rate, strain and displacement. Blood pressure and heart rate changed significantly after sternotomy, but the TDI derived data did not change significantly. In Paper II we report that movement artifacts of the laser Doppler myocardial perfusion measurements can be reduced, both when myocardium is normally perfused and during coronary occlusion, by using the TDI velocity registrations showing wall motion to be minimal. The optimum interval depends on the application but late systole as well as late diastole is preferred. After LVAD implantation in Paper III the flow characteristics and myocardial motion during variations in afterload TDI show that myocardial velocities decrease concomitantly with myocardial depression and are significantly correlated to native stroke volume, heart rate, systemic arterial resistance and cardiac output, but not with left ventricular size, fractional shortening or pump speed. Echocardiography together with TDI thereby offers additional means for monitoring and quantifying residual myocardial function during LVAD treatment. SHI is superior in the early detection of single air-bubbles in the ascending aorta prior to significant air embolism during manipulation of the LVAD pump speed, as shown in Paper IV. A prompt decrease in size of the left atrium during speed adjustment may be a warning that massive air embolism is imminent whereas the commonly used left atrial pressure not provide the same warning.
The title of article II is in the list of publications "Correlation between laser Doppler perfusion monitoring and myocardial tissue Doppler echocardiography in the beating heart" and in the published article the title is "Myocardial tissue motion influence on laser Doppler perfusion monitoring using tissue Doppler imaging".

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Leclair, Robert J. "X-ray scatter imaging in medicine, model and experimental validation". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0017/NQ57615.pdf.

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Leclair, Robert J. (Robert Joseph) Carleton University Dissertation Physics. "X-ray scatter imaging in medicine; model and experimental validation". Ottawa, 2000.

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Galloway, D. J. "Dietary manipulation of experimental colorectal cancer". Thesis, University of Glasgow, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.374513.

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Mais fontes

Livros sobre o assunto "Experimental medicine"

Stewart, Wolf, ed. Experimental Medicine. London: Taylor and Francis, 2017.

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R, Clark William. The experimental foundations of modern immunology. 4^a ed. New York: Wiley, 1991.

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1947-, Magura Stephen, Rosenblum Andrew e Stimmel Barry 1939-, eds. Experimental therapeutics in addiction medicine. New York: Haworth Medical Press, 1994.

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International Workshop on Immune-Deficient Animals (6th 1988 Beijing, China). Immune-deficient animals in experimental medicine. Editado por Wu Bing-quan 1930- e Zheng Jie. Basel: Karger, 1989.

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International Workshop on Immune-Deficient Animals. (6th 1988 Peking, China). Immune-deficient animals in experimental medicine. Editado por Wu Bing-quan 1930- e Zheng Jie. Basel: Karger, 1989.

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1930-, Wu Bing-quan, e Zheng Jie, eds. Immune-deficient animals in experimental medicine. Basel: Karger, 1989.

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Shulin, Li, ed. Electroporation protocols: Experimental and clinical gene medicine. Totowa, N.J: Humana, 2008.

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Jung, K. 1942 Jan. 22-, Mattenheimer Hermann e Burchardt U, eds. Urinary enzymes in clinical and experimental medicine. Berlin: Springer-Verlag, 1992.

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Uwe, Hentschel, e Eurelings-Bontekoe Elisabeth H. M, eds. Experimental research in psychosomatics. Leiden, the Netherlands: DSWO Press, Leiden University, 1993.

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H, McNeill John, ed. Experimental models of diabetes. Boca Raton, Fla: CRC Press LLC, 1999.

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Capítulos de livros sobre o assunto "Experimental medicine"

Ellenbroek, Bart, Alfonso Abizaid, Shimon Amir, Martina de Zwaan, Sarah Parylak, Pietro Cottone, Eric P. Zorrilla et al. "Experimental Medicine". In Encyclopedia of Psychopharmacology, 521. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-68706-1_3256.

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Turner, J. Rick. "Experimental Designs". In Encyclopedia of Behavioral Medicine, 814. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-39903-0_1022.

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Turner, J. Rick. "Experimental Group". In Encyclopedia of Behavioral Medicine, 814–15. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-39903-0_1023.

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LaCaille, Lara, Anna Maria Patino-Fernandez, Jane Monaco, Ding Ding, C. Renn Upchurch Sweeney, Colin D. Butler, Colin L. Soskolne et al. "Experimental Analyses". In Encyclopedia of Behavioral Medicine, 732. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-1005-9_1021.

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LaCaille, Lara, Anna Maria Patino-Fernandez, Jane Monaco, Ding Ding, C. Renn Upchurch Sweeney, Colin D. Butler, Colin L. Soskolne et al. "Experimental Designs". In Encyclopedia of Behavioral Medicine, 732. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-1005-9_1022.

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LaCaille, Lara, Anna Maria Patino-Fernandez, Jane Monaco, Ding Ding, C. Renn Upchurch Sweeney, Colin D. Butler, Colin L. Soskolne et al. "Experimental Group". In Encyclopedia of Behavioral Medicine, 732–33. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-1005-9_1023.

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Nahler, Gerhard. "experimental drug". In Dictionary of Pharmaceutical Medicine, 71. Vienna: Springer Vienna, 2009. http://dx.doi.org/10.1007/978-3-211-89836-9_530.

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Nahler, Gerhard. "experimental trial". In Dictionary of Pharmaceutical Medicine, 71. Vienna: Springer Vienna, 2009. http://dx.doi.org/10.1007/978-3-211-89836-9_531.

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Christensen, Robert D. "Medicinal Uses of Hematopoietic Growth Factors in Neonatal Medicine". In Handbook of Experimental Pharmacology, 257–83. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/164_2019_261.

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Abrams, David B., J. Rick Turner, Linda C. Baumann, Alyssa Karel, Susan E. Collins, Katie Witkiewitz, Terry Fulmer et al. "Applied Experimental Psychology". In Encyclopedia of Behavioral Medicine, 125. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-1005-9_100105.

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Trabalhos de conferências sobre o assunto "Experimental medicine"

"Research Status and the Problems of Traditional Chinese Medicine Sterilization". In 2020 International Clinical & Experimental Pharmacology and Oncology Forum. Association for Computer, Electronics and Education, 2020. http://dx.doi.org/10.48062/978-1-7773850-1-9.004.

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"Information Retrieval in Medicine - An Extensive Experimental Study". In International Conference on Health Informatics. SCITEPRESS - Science and and Technology Publications, 2014. http://dx.doi.org/10.5220/0004909904470452.

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Thomsen, Sharon, John A. Pearce, Andrew Giustini e P. Jack Hoopes. "Nanoparticles in medicine: selected observations and experimental caveats". In SPIE BiOS, editado por Thomas P. Ryan. SPIE, 2013. http://dx.doi.org/10.1117/12.2008900.

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Garg, Ridita, Isha Bhatt, K. Eashwer e Sumit Kumar Jindal. "Experimental Design and Implementation of RFID based Clinical Medicine Dispenser". In 2022 1st International Conference on the Paradigm Shifts in Communication, Embedded Systems, Machine Learning and Signal Processing (PCEMS). IEEE, 2022. http://dx.doi.org/10.1109/pcems55161.2022.9807886.

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Tulibacki, Marek P., Andrzej Kukwa, Andrzej Zajac e Waldemar Zendzian. "YAG laser in experimental and clinical surgery of the head and neck". In Lasers in Medicine, editado por Tadeusz Kecik e Wlodzimierz Nowakowski. SPIE, 1996. http://dx.doi.org/10.1117/12.236834.

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Kecik, Tadeusz, Dariusz Kecik, Jan Kasprzak, Antoni Pratnicki, Zdzislaw Jankiewicz e Andrzej Zajac. "Experimental studies on the usage possibilities of the holmium laser in cataract surgery". In Lasers in Medicine, editado por Tadeusz Kecik e Wlodzimierz Nowakowski. SPIE, 1996. http://dx.doi.org/10.1117/12.236839.

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Sidoruk, Krystsina, e Aleksey Ustyugov. "EXPERIMENTAL CELL MODELS FOR PROTEINOPATHIES". In XV International interdisciplinary congress "Neuroscience for Medicine and Psychology". LLC MAKS Press, 2019. http://dx.doi.org/10.29003/m554.sudak.ns2019-15/376-377.

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Starfield, David M., David M. Rubin, Tshilidzi Marwala e Rex J. Keddy. "High-transparency coded apertures in planar nuclear medicine imaging: Experimental results". In 2007 IEEE Nuclear Science Symposium Conference Record. IEEE, 2007. http://dx.doi.org/10.1109/nssmic.2007.4436796.

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Lychagov, Vladislav V., Valery V. Tuchin, Maxim A. Vilensky, Eugeny P. Savchenko, Alexander A. Efimov, Nina A. Lakodina, Luis De Taboada e Boris N. Reznik. "Experimental study of cadaver head transmittance". In Saratov Fall Meeting 2004: Optical Technologies in Biophysics and Medicine VI, editado por Valery V. Tuchin. SPIE, 2005. http://dx.doi.org/10.1117/12.634768.

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Rizkalla, A. S., D. W. Jones, T. Archibald, G. C. Hall e M. Langman. "ELASTIC MODULUS OF EXPERIMENTAL BIOACTIVE GLASS COMPOSITES". In Proceedings of the 12th International Symposium on Ceramics in Medicine. WORLD SCIENTIFIC, 1999. http://dx.doi.org/10.1142/9789814291064_0098.

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Relatórios de organizações sobre o assunto "Experimental medicine"

Azoulay, Pierre, e Ariel Fishman. The Rise of For-Profit Experimental Medicine. Cambridge, MA: National Bureau of Economic Research, março de 2020. http://dx.doi.org/10.3386/w26892.

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Wang, Fei, QY Wu, QY Zhang, SS Ma, KY Wang e Y. Zhang. A Meta-analysis and Experimental Sequential Analysis of Gegen Qinlian Decoction Combined with Conventional Western Medicine in the Treatment of Infective Diarrhea. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, março de 2022. http://dx.doi.org/10.37766/inplasy2022.3.0165.

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Tang, Jiqin, Gong Zhang, Jinxiao Xing, Ying Yu e Tao Han. Network Meta-analysis of Heat-clearing and Detoxifying Oral Liquid of Chinese Medicines in Treatment of Children’s Hand-foot-mouth Disease：a protocol for systematic review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, janeiro de 2022. http://dx.doi.org/10.37766/inplasy2022.1.0032.

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Review question / Objective: The type of study was clinical randomized controlled trial (RCT). The object of study is the patients with HFMD. There is no limit to gender and race. In the case of clear diagnosis standard, curative effect judgment standard and consistent baseline treatment, the experimental group was treated with pure oral liquid of traditional Chinese medicine(A: Fuganlin oral liquid, B: huangzhihua oral liquid, C: Lanqin oral liquid, D: antiviral oral liquid, E: Huangqin oral liquid, F: Pudilan oral liquid, G: Shuanghuanglian oral liquid.)and the control group was treated with ribavirin or any oral liquid of traditional Chinese medicine. The data were extracted by two researchers independently, cross checked and reviewed according to the pre-determined tables. The data extraction content is (1) Basic information (including the first author, published journal and year, research topic). (2) Relevant information (including number of cases, total number of cases, gender, age, intervention measures, course of treatment of the experimental group and the control group in the literature). (3) Design type and quality evaluation information of the included literature. (4) Outcome measures (effective rate, healing time of oral ulcer, regression time of hand and foot rash, regression time of fever, adverse reactions.). The seven traditional Chinese medicine oral liquids are comparable in clinical practice, but their actual clinical efficacy is lack of evidence-based basis. Therefore, the purpose of this study is to use the network meta-analysis method to integrate the clinical relevant evidence of direct and indirect comparative relationship, to make quantitative comprehensive statistical analysis and sequencing of different oral liquid of traditional Chinese medicine with the same evidence body for the treatment of the disease, and then to explore the advantages and disadvantages of the efficacy and safety of different oral liquid of traditional Chinese medicine to get the best treatment plan, so as to provide reference value and evidence-based medicine evidence for clinical optimization of drug selection. Condition being studied: Hand foot mouth disease (HFMD) is a common infectious disease in pediatrics caused by a variety of enteroviruses. Its clinical manifestations are mainly characterized by persistent fever, hand foot rash, oral herpes, ulcers, etc. Because it is often found in preschool children, its immune system development is not perfect, so it is very vulnerable to infection by pathogens and epidemic diseases, resulting in rapid progress of the disease. A few patients will also have neurogenic pulmonary edema Meningitis, myocarditis and other serious complications even lead to death, so effectively improve the cure rate, shorten the course of disease, prevent the deterioration of the disease as the focus of the study. In recent years, traditional Chinese medicine has played an important role in the research of antiviral treatment. Many clinical practices have confirmed that oral liquid of traditional Chinese medicine can effectively play the role of antiviral and improve the body's immunity.

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XU, Fangyuan, Qiqi Yang, Wenchao ZHANG e Wei HUANG. Effects of acupuncture and moxibustion in reducing urine leakage for female stress urinary incontinence: A protocol for an overview of systematic reviews and meta-analyses. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, março de 2022. http://dx.doi.org/10.37766/inplasy2022.3.0100.

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Review question / Objective: Participants: Female patients who are diagnosed with SUI according to any widely recognized and accepted criteria, regardless of their age, ethnicity, education, or social status. Interventions: The treatment used in the experimental group mainly includes acupuncture, electroacupuncture, warm needle acupuncture, stick-moxibustion, direct-moxibustion, partition moxibustion, or one of the above therapies combined with traditional Chinese medicine or pelvic floor muscle exercise. Comparator/control: The control groups were treated with conventional western medicine, pelvic floor muscle exercise, electrical stimulation, or placebo. Outcome indicators: (1) Primary outcomes: effective rate, urine leakage in 1-hour pad test; (2) Secondary outcomes: International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF) score, pelvic floor muscle strength, frequency of 24-hour urinary incontinence, and adverse reactions. Types of studies: Peer-reviewed SRs and MAs based on randomized controlled trials (RCTs) will be included in this overview.

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Yuan, Yu, Linjia Wang, Yuan Chen, Mengdi Zhou, Bingyu Hu e Ling Zhao. Acupuncture therapy for subacute and chronic cough in adults: a systematic review and meta analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, julho de 2022. http://dx.doi.org/10.37766/inplasy2022.7.0110.

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Review question / Objective: The effectiveness of acupuncture in the treatment of subacute and chronic cough. Eligibility criteria: In the literature, the intervention measures of the treatment group were acupuncture or acupuncture combined with other therapies agent, while the control group was placebo or oral non-acupuncture therapy such as western medicine and Chinese medicine; In the same study, when the treatment group was acupuncture combined with other treatment methods, the intervention measures adopted by the control group, except no acupuncture intervention, must be the same as the experimental group .We excluded trials comparing one acupuncture therapy with another, or trials comparing the use of other non- acupuncture related therapy in this review, and trials where acupuncture therapy were not the main intervention were excluded. No limitations were imposed concerning the duration of the application, dosage, or the form of the acupuncture therapy used. We included trials that allowed concurrent use of other medications such as analgesics, antitussives, antipyretics, or mucolytics if they allowed equal access to such medication.

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Li, Xiao, Fayang Ling, Wenchuan Qi, Sanmei Xu, Bingzun Yin, Zihan Yin, Qianhua Zheng, Xiang Li e Fanrong Liang. Preclinical Evidence of Acupuncture on infarction size of Myocardial ischemia: A Systematic Review and Meta-Analysis of Animal Studies. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, junho de 2022. http://dx.doi.org/10.37766/inplasy2022.6.0044.

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Review question / Objective: Whether acupuncture is effective for infarction size on myocardial ischemia rat models. Condition being studied: Myocardial ischemia is a typical pathological condition of coronary heart disease (CHD), which has been a global issue with high incidence and mortality. Myocardial infarction caused by myocardial ischemia leads to cardiac dysfunction, and the size of myocardial infarction also determines the recovery and prognosis of cardiac function. Acupuncture, a long history of traditional Chinese medicine, is widely used to treat symptoms like thoracalgia and palpitation. Many researches based on rat experiments have shown that acupuncture affects infarction size, cardiac function, myocardial enzyme or arrhythmias severity on myocardial ischemia models; nevertheless, few literatures have systematically reviewed these studies, assessing the risk of bias, quality of evidence, validity of results, and summarizing potential mechanisms. A systematic review of animal studies can benefit future experimental designs, promote the conduct and report of basic researches and provide some guidance to translate the achievements of basic researches to clinical application in acupuncture for myocardial ischemia. Therefore, we will conduct this systematic review and meta analysis to evaluate effects of acupuncture on infarction size on myocardial ischemia rat models.

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Peng, Ciyan, Jing Chen, Sini Li e Jianhe Li. Comparative Efficacy of Chinese Herbal Injections Combined Western medicine for Non-small cell lung cancer: A Bayesian Network Meta-Analysis of randomized controlled trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, novembro de 2021. http://dx.doi.org/10.37766/inplasy2021.11.0068.

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Review question / Objective: Advanced lung cancer has become the top malignant tumor in terms of morbidity and mortality, and Chinese herbal injections combined with western drugs have been widely used to treat advanced non-small cell lung cancer. For this purpose, we conducted a Bayesian network analysis to systematically evaluate the efficacy of different herbal injections combined with western drugs in the treatment of NSCLC. Subjects: Patients diagnosed with NSCLC by pathological or cytological examination, locally advanced or those who refused surgical treatment were included, regardless of gender, age, stage, race, nationality and sample size; Interventions: Chinese herbal injections combined with three types of commonly used western drugs (platinum, targeted and immune agents) were used in the experimental group, while the control group was treated with western drugs alone; Study type: to report the efficacy of Chinese herbal injections combined with western drugs in the treatment of non-small cell lung cancer efficacy in a randomized controlled trial (rct) Eligible. No restrictions were imposed on language, year of publication, or publication status. Ending indicators: Main ending indicators: (1) disease control rate (DCR), DCR = (complete remission + partial remission + stable)/total number of cases. Efficacy rate = (number of improvement cases + number of stable cases)/total number of cases. (2) Secondary outcome indicators: quality of life, determined according to the KPS behavioral status scale, improvement was defined as an increase of ≥10 points in KPS score after treatment; stability was defined as an increase or decrease of <10 points in KPS score; decline was defined as a decrease of ≥10 points in KPS score. (3) The incidence of adverse reactions, including gastrointestinal reactions, white blood cell (WBC) reduction, hemoglobin (HGB) reduction, platelet (PLT) reduction, etc.

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Kling, Jeffrey, Sendhil Mullainathan, Eldar Shafir, Lee Vermeulen e Marian Wrobel. Comparison Friction: Experimental Evidence from Medicare Drug Plans. Cambridge, MA: National Bureau of Economic Research, setembro de 2011. http://dx.doi.org/10.3386/w17410.

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Mayanja, Maureen Nanziri, Rebecca Nalubega, John R. S. Tabuti e Collins Grace Atuheire. Effectiveness of Ethnoveterinary Medicinal Plants of Eastern Africa in Control of Livestock Pests or Disease Pathogens: A Systematic Review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, setembro de 2022. http://dx.doi.org/10.37766/inplasy2022.9.0006.

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Review question / Objective: a) What is the current state and distribution of evidence on medicinal plants for ethnoveterinary practice in livestock keeping communities in Eastern Africa? b) What evidence exists about the pharmacological activities and effectiveness in control of livestock pests or disease pathogens, of ethnoveterinary medicinal plants accessible to the drylands of Eastern Africa? Information sources: This systematic review will consider both experimental and quasi-experimental evaluation studies that report positive outcomes; in-vivo and in-vitro assays and phytochemical composition assessment. Qualitative studies that focus on ethnoveterinary medicinal plant use including, but not limited to qualitative description and action research, will also be considered. In addition, systematic reviews that meet the inclusion criteria will be considered.

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Kriegel, Francesco. Learning General Concept Inclusions in Probabilistic Description Logics. Technische Universität Dresden, 2015. http://dx.doi.org/10.25368/2022.220.

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Probabilistic interpretations consist of a set of interpretations with a shared domain and a measure assigning a probability to each interpretation. Such structures can be obtained as results of repeated experiments, e.g., in biology, psychology, medicine, etc. A translation between probabilistic and crisp description logics is introduced and then utilised to reduce the construction of a base of general concept inclusions of a probabilistic interpretation to the crisp case for which a method for the axiomatisation of a base of GCIs is well-known.

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