Literatura científica selecionada sobre o tema "Drum sound synthesis"
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Artigos de revistas sobre o assunto "Drum sound synthesis"
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Brezas, Spyros, Alexandros Skoulakis, Maximos Kaliakatsos-Papakostas, Antonis Sarantis-Karamesinis, Yannis Orphanos, Michael Tatarakis, Nektarios A. Papadogiannis, Makis Bakarezos, Evaggelos Kaselouris e Vasilis Dimitriou. "Audio Recognition of the Percussion Sounds Generated by a 3D Auto-Drum Machine System via Machine Learning". Electronics 13, n.º 9 (6 de maio de 2024): 1787. http://dx.doi.org/10.3390/electronics13091787.
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A novel 3D auto-drum machine system for the generation and recording of percussion sounds is developed and presented. The capabilities of the machine, along with a calibration, sound production, and collection protocol are demonstrated. The sounds are generated by a drumstick at pre-defined positions and by known impact forces from the programmable 3D auto-drum machine. The generated percussion sounds are accompanied by the spatial excitation coordinates and the correspondent impact forces, allowing for large databases to be built, which are required by machine learning models. The recordings of the radiated sound by a microphone are analyzed using a pre-trained deep learning model, evaluating the consistency of the physical sample generation method. The results demonstrate the ability to perform regression and classification tasks when fine tuning the deep learning model with the gathered data. The produced databases can properly train machine learning models, aiding in the investigation of alternative and cost-effective materials and geometries with relevant sound characteristics and in the development of accurate vibroacoustic numerical models for studying percussion instruments sound synthesis.
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Bilbao, Stefan. "Time domain simulation and sound synthesis for the snare drum". Journal of the Acoustical Society of America 131, n.º 1 (janeiro de 2012): 914–25. http://dx.doi.org/10.1121/1.3651240.
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Ruiz-González, María Luisa, Almudena Torres-Pardo e José M. González-Calbet. "The Role of Transmission Electron Microscopy in the Early Development of Mesoporous Materials for Tissue Regeneration and Drug Delivery Applications". Pharmaceutics 13, n.º 12 (20 de dezembro de 2021): 2200. http://dx.doi.org/10.3390/pharmaceutics13122200.
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For the last 20 years, silica-based mesoporous materials have provided a sound platform for the development of biomedical technology applied to tissue engineering and drug delivery. Their unique structural and textural characteristics, chiefly, the ordered distribution of homogeneous and tunable pores with high surface areas and large pore volume, and their excellent biocompatibility provide an excellent starting point for bone tissue regeneration on the mesoporous surface, and also to load species of interest inside the pores. Adequate control of the synthesis conditions and functionalization of the mesoporous surface are critical factors in the design of new systems that are suitable for use in specific medical applications. Simultaneously, the use of appropriate characterization techniques in the several stages of design and manufacture of mesoporous particles allows us to ascertain the textural, structural and compositional modifications induced during the synthesis, functionalization and post-in vitro assays processes. In this scenario, the present paper shows, through several examples, the role of transmission electron microscopy and associated spectroscopic techniques in the search for useful information in the early design stages of mesoporous systems, with application in the fields of tissue regeneration and drug delivery systems.
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Stang, Paul E., Janet L. Fox, Abraham G. Hartzema, Miquel S. Porta e Hugh H. Tilson. "Adverse Drug Events and the Freedom of Information Act: An Apple in Eden". Annals of Pharmacotherapy 26, n.º 2 (fevereiro de 1992): 238–43. http://dx.doi.org/10.1177/106002809202600220.
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OBJECTIVE: To review some of the abuses and proper uses of the Food and Drug Administration's (FDA's) spontaneous adverse-reaction reporting system, as a way of educating the reader to its strengths and limitations. DATA SOURCE: Published literature and reports based on information obtained from the FDA's database of spontaneous adverse drug-event reports. DATA SYNTHESIS: The Freedom of Information Act has increased public access to the FDA's database of spontaneous adverse drug reaction reports. As these reports are voluntarily received and reported to the FDA, their use for comparisons of drug safety is severely limited. Despite these limitations and the FDA's caveats for use of these data, consumer advocacy groups, researchers, and various pharmaceutical marketing groups have used this source to project the incidence of adverse drug reactions. CONCLUSIONS: The FDA's spontaneous adverse-event reporting system is designed to generate signals of unexpected adverse drug events. Use of the data gathered by this system to make drug safety comparisons is beyond their credible scope because many factors influence the reporting of adverse events. Researchers and peer reviewers should place these data in the proper perspective and support sound research into questions of drug safety.
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Bakliwal, A. A., D. S. Jat, S. G. Talele e A. G. Jadhav. "FORMULATION AND EVALUATION OF NATEGLINIDE NANOSPONGES". INDIAN DRUGS 55, n.º 02 (26 de fevereiro de 2018): 27–35. http://dx.doi.org/10.53879/id.55.02.10717.
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The objective of the present study was to produce extended release nateglinide nanosponges for oral delivery. Preparation of nanosponges leads to solubility enhancement. Nateglinide is a BCS Class II drug, having low solubility. So, to increase the solubility of nateglinide it is formulated into nanosponges. Nanosponges using ethyl cellulose as a polymer and dichloromethane as a cross-linker were prepared successfully by ultra-sound assisted synthesis method. The effects of different drug: placebo ratios on the physical characteristics of the nanosponges as well as the drug content and in vitro drug release of the nanosponges were investigated. Particle size analysis and surface morphology of nanosponges were performed. The scanning and transmission electron microscopy of nanosponges showed that they were spongy in nature. The particle size was found to be in the range 46.37 - 97.23 nm out of which particle size of the optimized formulation was 51.79 nm and the drug content was found to 79.43 %. The optimized nanosponge formulations were selected for preparing nanosponge tablets for extended drug delivery by oral route. These tablets were prepared using xanthan gum and PVP K-30 and were evaluated by pre-compression and post-compression parameters. The nateglinide nanosponges tablet formulation were studied for different parameters using Design Expert Software. All formulations were evaluated for in vitro drug release analyzed according to various release kinetic models and it was found that it follows zero order release kinetics.
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Rapeti, Durgababu, Kapavarapu Maruthi Venkata Narayanarao, Pulipaka Shyamala e Rallabhandi Murali Krishna. "Identification of the Organic Volatile Impurities in Ezitamibe using GC-HS Technique". Asian Journal of Chemistry 33, n.º 3 (2021): 605–10. http://dx.doi.org/10.14233/ajchem.2021.23071.
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Ezetimibe prevents intestinal cholesterol synthesis, which in turn reduces the quantity of cholesterol and thereby helps to reduce heart problems and strokes. In the production of ezetimibe, several organic chemical solvents such as methanol, acetone, isopropyl alcohol, dichloromethane, n-hexane, ethyl acetate, tetrahydrofuran, toluene and dimethyl formamide were used. The measurement of residual solvents is necessary for release checks of all drug substances, based on sound manufacturing processes. The analysis of above mentioned nine solvents in ezetimibe drug was investigated using gas chromatographic method employing detection with flame ionization mode. All analyses were performed using ZB-624 column (30 m length × 0.53 mm identification, 3.0 μm thickness film). The column oven temperature flux was managed to maintain for 11 min at 40 ºC and then continued to upsurge to a temperature close of 240 ºC at a rate of 20 ºC/min and retained for 4 min. The flame ionization detector and injector port were managed at 260 and 200 ºC, respectively. Results after the validation of the gas chromatographic method showed the satisfactory linearity, sensitivity, robustness, accuracy, selectivity and precision for the tested organic solvents. This gas chromatographic approach can therefore be exploited in the assessment of studied nine residual chemical solvents for periodic analysis by gas chromatography for samples of ezetimibe drug.
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Tiwari, Shashank, Kartikay Prakash e Devbrat Soni. "Rudimentary Review on Molecular Docking: A Beginner’s Guide". International Journal of Pharma Professional’s Research (IJPPR) 14, n.º 4 (15 de novembro de 2023): 73–83. http://dx.doi.org/10.48165/ijppronline.2023.14406.
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The computer modelling of structural complexes generated from two or more interacting molecules are referred to as molecular docking. It is an indispensable tool in computer-aided drug design and structural molecular biology. Using this technology, large libraries of compounds may be digitally screened, and the results can be graded along with structural assumptions about how the ligands impact the target's reduction. Recent advances in the synthesis of anti-infectious medicines prompted by structural insights have enabled the application of computer-assisted drug design in the quest for innovative mechanism- or structure-based drugs. Molecular docking is an important phase in the drug development process because it determines the best positions for molecules to occupy when they are coupled together and predicts how effectively two molecules will bind once they have been docked. The input structure's design is also critical, and the results are assessed using sampling methods and scoring systems. The recently developed docking software Local Move Monte Carlo [LMMC] provides a strong choice for customizable receptor docking strategies. Docking is a technique for determining how ligands and proteins interact. It is structurally sound and compatible with computer-assisted medication design. Successful docking discovers high-dimensional spaces and ranks function utilisation, resulting in a candidate docking rating that is acceptable. It may also be used to screen vast libraries of molecules and offer structural hypotheses for the process.
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Maroyi, Alfred. "Ximenia caffra Sond. (Ximeniaceae) in sub-Saharan Africa: A synthesis and review of its medicinal potential". Journal of Ethnopharmacology 184 (maio de 2016): 81–100. http://dx.doi.org/10.1016/j.jep.2016.02.052.
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Zhang, Manyu, Wei Li, Lan Hu, Li Chen, Liu Yang, Tian Zhang, Hui Shen et al. "Oral propranolol for treatment of the subgroups of essential tremor: a systematic review and meta-analysis protocol". BMJ Open 10, n.º 1 (janeiro de 2020): e032096. http://dx.doi.org/10.1136/bmjopen-2019-032096.
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IntroductionEssential tremor (ET), a tremor disorder, is one of the most common movement disorders. Only oral drugs (propranolol, primidone, topiramate, etc）are still the first-line treatment recommended by the Food and Drug Administration. Propranolol is thought to potentially reduce upper limb action tremor. However, it has a poor effect on axial tremor symptoms, such as essential head tremor and voice tremor. Studies have shown that tremor severity develops over time, possibly producing other clinical tremors and neurological soft signs (such as memory loss, gait abnormalities, balance disorders, etc), which further increases the difficulty of treating tremors. However, some recent studies provide emerging evidence for oral propranolol on subgroups of ET, which is based on the anatomical distribution of ET (lower extremities, head, sound, tongue, etc). This systematic review aims to synthesise these new data to improve the efficacy of propranolol in ET subgroups.Methods and analysisWe will search for randomised controlled trials from the PubMed, MEDLINE, EMBASE, Cochrane Library, UptoDate and PEDro databases from inception to June 2019. All data will be extracted independently by two reviewers and compared at the end of the review. The two reviewers will screen the study quality, and the Cochrane Collaboration’s tool in Review Manager (RevMan) V.5.3.3 will be used to evaluate risk of bias. Our primary outcome will be the functional disability component related to tremors, as measured by the Fahn-Tolosa-Marin Tremor Rating Scale subscales B and C. Secondary outcomes will include severity of tremors and quality of life. Narrative and meta-analytical syntheses are planned.Ethics and disseminationPublished aggregated data will be used in this review analysis and therefore no ethical approval is required. The results will be published in peer-reviewed journals, and proliferation activities will include diverse social stakeholders, non-academic groups and patients.PROSPERO registration numberCRD42018112580
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Kędzierska, Magdalena, Piotr Potemski, Anna Drabczyk, Sonia Kudłacik-Kramarczyk, Magdalena Głąb, Beata Grabowska, Dariusz Mierzwiński e Bożena Tyliszczak. "The Synthesis Methodology of PEGylated Fe3O4@Ag Nanoparticles Supported by Their Physicochemical Evaluation". Molecules 26, n.º 6 (20 de março de 2021): 1744. http://dx.doi.org/10.3390/molecules26061744.
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Many investigations are currently being performed to develop the effective synthesis methodology of magnetic nanoparticles with appropriately functionalized surfaces. Here, the novelty of the presented work involves the preparation of nano-sized PEGylated Fe3O4@Ag particles, i.e., the main purpose was the synthesis of magnetic nanoparticles with a functionalized surface. Firstly, Fe3O4 particles were prepared via the Massart process. Next, Ag+ reduction was conducted in the presence of Fe3O4 particles to form a nanosilver coating. The reaction was performed with arabic gum as a stabilizing agent. Sound energy-using sonication was applied to disintegrate the particles’ agglomerates. Next, the PEGylation process aimed at the formation of a coating on the particles’ surface using PEG (poly(ethylene glycol)) has been performed. It was proved that the arabic gum limited the agglomeration of nanoparticles, which was probably caused by the steric effect caused by the branched compounds from the stabilizer that adsorbed on the surface of nanoparticles. This effect was also enhanced by the electrostatic repulsions. The process of sonication caused the disintegration of aggregates. Formation of iron (II, III) oxide with a cubic structure was proved by diffraction peaks. Formation of a nanosilver coating on the Fe3O4 nanoparticles was confirmed by diffraction peaks with 2θ values 38.15° and 44.35°. PEG coating on the particles’ surface was proven via FT-IR (Fourier Transform Infrared Spectroscopy) analysis. Obtained PEG–nanosilver-coated Fe3O4 nanoparticles may find applications as carriers for targeted drug delivery using an external magnetic field.
Capítulos de livros sobre o assunto "Drum sound synthesis"
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Origer, Alain. "Controlled Drugs, Use, Abuse and Youth: A Meaningful, Yet Evolving Relationship". In Wohlbefinden und Gesundheit im Jugendalter, 343–61. Wiesbaden: Springer Fachmedien Wiesbaden, 2022. http://dx.doi.org/10.1007/978-3-658-35744-3_16.
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AbstractPsychoactive substances take a functional role in the management of emotional and social life of humankind. However, the bond between mind-altering substances and their users or potential users is of changing nature, since the diversity and the accessibility of these substances, as well as the perception of expected benefits and related risks are constantly evolving. Science and technology have contributed to develop new or more potent drugs. The legal status of drugs has become blurrier with the emergence of new synthetic psychoactive substances, highly accessible and most attractive, especially to younger users. New information and communication technologies have changed the way information is spreading among us as well as the means and channels to procure various controlled and non-controlled substances. The increasing popularity and varieties of hemp and psychoactive cannabis products, their developing medicinal use and their potential impact on the perception and acceptance of cannabis are equally at stake when it comes to understand changing patterns in cannabis use for instance. More opportunities stand for more choices to make, especially by young people. Knowing that regular drug use bear highest risks, notably in terms of cognitive and psychosocial developments in children and adolescents, it is sound to question its impact on public health and challenges in terms of prevention, demand and harm reduction. This paper reflects the attempt to describe and to analyse evolutions in drug supply, drug demand and drug use as well as other behaviors with addictive potential in youngsters over the last two decades in Luxembourg and to address national specificities, trends and challenges in terms of response and to place the national situation in a wider international context.
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Stockley, Naomi, Rianna Tatana, Roshni Kaur e Alice Reynolds. "The Pavilion School, Melbourne, Australia". In Systematic synthetic phonics: case studies from Sounds-Write practitioners, 113–23. Research-publishing.net, 2022. http://dx.doi.org/10.14705/rpnet.2022.55.1366.
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The Pavilion School is located in Melbourne, Australia. It is a specialist Flexible Learning Option (FLO) for students who have disengaged or been excluded from mainstream education. There are 235 secondary-aged school students enrolled across two campuses in Melbourne’s northern suburbs. A considerable proportion of students at the Pavilion School face significant risk factors which impede their access to education. They are as follows: mental health challenges (60% of students); alcohol and other drug use (49%); school absenteeism (47%); family vulnerability (47%); and youth justice involvement (16%). Other relevant demographics that make up our student population include the following: 25% receive funding as part of the Program for Students with Disabilities (PSD); 24% identify as Aboriginal and Torres Strait Islander; and 10% are in Out of Home Care.
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Kiani, Bushra Hafeez. "Metallic Nanoparticles Synthesized Through Medicinal Plants: Therapeutic Improvement". In Medicinal Plants: Microbial Interactions, Molecular Techniques and Therapeutic Trends, 230–55. BENTHAM SCIENCE PUBLISHERS, 2023. http://dx.doi.org/10.2174/9789815136838123010017.
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The field of nanotechnology has developed new medicinal nanoparticles that have various uses in pharmaceutics and healthcare. Distinct macroscopic and microscopic entities including plants, fungi, microalgae, bacilli, and seaweed have been used to biosynthesize nanoparticles. Naturally-occurring chemicals like flavonoids, tannins, alkaloids, steroids, and saponins are abundantly present in plants. A potentially unharmful method to produce nanoparticles can be through extracts of different plants. As plant extracts carry many specialized metabolites, they can act as stabilizers and reducers in bioreduction reactions that take place in metallic nanoparticle production. The production of metallic nanoparticles by biological techniques is an easier, cheaper, and more environmentally sound option in comparison with other physical and chemical techniques that are extremely toxic and unsafe for biological use. Greener nanoparticles like Co, Cu, Ag, Pd, Au, ZnO, Pt, and Fe3O4 have been biosynthesized using medicinal plants. These nanoparticles have various uses in pharmaceutics ranging from gene delivery, drug delivery, pathogen detection, tissue engineering, and protein detection. Not only that but, metallic nanoparticles can also potentially be remedies to different acute diseases including hepatitis, human immunodeficiency virus, malaria, and even cancer. Improvements in drug delivery and tissue engineering have been made possible by nanotechnology and this has greatly facilitated translational level studies that relate to pharmaceutics. In this chapter, green syntheses of metallic nanoparticles through medicinal plants along with their uses in therapeutic improvements are described.
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Tzanetakis, George. "Natural Human-Computer Interaction with Musical Instruments". In Advances in Multimedia and Interactive Technologies, 116–36. IGI Global, 2016. http://dx.doi.org/10.4018/978-1-5225-0264-7.ch006.
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The playing of a musical instrument is one of the most skilled and complex interactions between a human and an artifact. Professional musicians spend a significant part of their lives initially learning their instruments and then perfecting their skills. The production, distribution and consumption of music has been profoundly transformed by digital technology. Today music is recorded and mixed using computers, distributed through online stores and streaming services, and heard on smartphones and portable music players. Computers have also been used to synthesize new sounds, generate music, and even create sound acoustically in the field of music robotics. Despite all these advances the way musicians interact with computers has remained relatively unchanged in the last 20-30 years. Most interaction with computers in the context of music making still occurs either using the standard mouse/keyboard/screen interaction that everyone is familiar with, or using special digital musical instruments and controllers such as keyboards, synthesizers and drum machines. The string, woodwind, and brass families of instruments do not have widely available digital counterparts and in the few cases that they do the digital version is nowhere as expressive as the acoustic one. It is possible to retrofit and augment existing acoustic instruments with digital sensors in order to create what are termed hyper-instruments. These hyper-instruments allow musicians to interact naturally with their instrument as they are accustomed to, while at the same time transmitting information about what they are playing to computing systems. This approach requires significant alterations to the acoustic instrument which is something many musicians are hesitant to do. In addition, hyper-instruments are typically one of a kind research prototypes making their wider adoption practically impossible. In the past few years researchers have started exploring the use of non-invasive and minimally invasive sensing technologies that address these two limitations by allowing acoustic instruments to be used without any modifications directly as digital controllers. This enables natural human-computer interaction with all the rich and delicate control of acoustic instruments, while retaining the wide array of possibilities that digital technology can provide. In this chapter, an overview of these efforts will be provided followed by some more detailed case studies from research that has been conducted by the author's group. This natural interaction blurs the boundaries between the virtual and physical world which is something that will increasingly happen in other aspects of human-computer interaction in addition to music. It also opens up new possibilities for computer-assisted music tutoring, cyber-physical ensembles, and assistive music technologies.
Trabalhos de conferências sobre o assunto "Drum sound synthesis"
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Lavault, Antoine, Axel Roebel e Matthieu Voiry. "StyleWaveGAN: Style-based synthesis of drum sounds using generative adversarial networks for higher audio quality". In 2022 30th European Signal Processing Conference (EUSIPCO). IEEE, 2022. http://dx.doi.org/10.23919/eusipco55093.2022.9909880.
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