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Artigos de revistas sobre o tema "Distemonanthus Benthamianus"

Autor: Grafiati

Publicado: 19 de outubro de 2024

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1

Matah Marte, Vanessa Mba, Gilbert Ateufack, Marius Mbiantcha, Albert Donatien Atsamo, Carine Flore Adjouzem, Stéphanie Flore Djuichou Nguemnang, Eric Gonzal Tsafack, William Yousseu Nana, Yacine Karelle Madjo Kouam e Elvira Ngoufack Azanze. "Methanolic Extract of Distemonanthus benthamianus (Caesalpiniaceae) Stem Bark Suppresses Ethanol/Indomethacin-Induced Chronic Gastric Injury in Rats". Gastroenterology Research and Practice 2020 (28 de novembro de 2020): 1–14. http://dx.doi.org/10.1155/2020/8180323.

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Distemonanthus benthamianus (Caesalpiniaceae) is a plant from the Cameroon pharmacopoeia very widely used in the treatment of many pathologies among which are gastrointestinal disorders. The main purpose of this study was to assess the healing properties of gastric ulcer from the methanolic extract of Distemonanthus benthamianus and its mechanisms of action. The healing properties of gastric ulcers (chronic ulcer model induced by ethanol and indomethacin) were evaluated in vivo in adult male rats, while the mechanisms of action were evaluated in vitro by anti-inflammatory assay (protein denaturation, cyclooxygenase, and lipoxygenase assays) and immunomodulatory assay (ROS production (using technical chemiluminescence), cytokine (TNF-α, IL-1β, IL-6) production (using ELISA), proliferation of T cells (using liquid scintillation counter), and cytotoxicity (using MTT assay)). The methanolic extract of Distemonanthus benthamianus inhibited protein denaturation (75.63%) and the activities of cyclooxygenase (78.92%) and 5-lipoxygenase (81.54%). The extract also significantly ( p < 0.001 ) inhibited intracellular and extracellular ROS production and T cell proliferation and reduced significantly ( p < 0.01 , p < 0.001 ) TNF-α, IL-1β, IL-6, and PGE2 production. At all doses (125, 250, and 500 mg/kg), the extract significantly reduces the ulceration index and the area of ulceration and significantly increases the mass of gastric mucus. In addition, the extract significantly decreases the level of MDA, significantly increases the activities of catalase and glutathione, and then improves the hematological parameters in sick animals. Histological micrographs show that in the presence of the extract, there is advanced reepithelialization with recovery of the ulcerated epithelium. Thus, the extract of Distemonanthus benthamianus has healing properties against gastric ulcers which are associated with its anti-inflammatory, immunomodulatory, and antioxidant effects.

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2

Happi, Emmanuel N., e Theophile N. Mpondo. "Two Polymethoxylated Flavones from Distemonanthus benthamianus". Journal of Natural Products 57, n.º 2 (fevereiro de 1994): 291–93. http://dx.doi.org/10.1021/np50104a015.

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Ogunsola, J. F., e K. E. Ogunsola. "Antimicrobial property of <i>Distemonanthus, Zanthoxylum, Morinda</i>, and <i>Moringa</i> species on potato (<i>Solanum tuberosum</i>) postharvest bacterial tuber rot". Ife Journal of Science 26, n.º 2 (28 de agosto de 2024): 457–69. http://dx.doi.org/10.4314/ijs.v26i2.17.

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Potato (Solanum tuberosum) is a very important crop globally with a high value for human nutrition. Its productivity in Nigeria is hindered by bacterial rot disease, which is commonly managed with synthetic pesticides despite its detriment to humans and the environment. This study investigated the antimicrobial potential of four botanicals (Distemonanthus benthamianus, Zanthoxylum zanthoxyloides (Zz), Morinda lucida, and Moringa oleifera (Mo) in vitro against four postharvest potato tuber rot-causing bacteria. One hundred rotted tubers were collected from four markets viz: Bodija, Sabo, and Apata, Ibadan (Oyo State), and Garki (Abuja). Three concentrations (500, 1000, and 1500mg/ml) of methanol extract of each of the botanicals were evaluated against the rot bacteria. The antimicrobial property of the most effective explant in vitro was evaluated in vivo against the rot bacteria. Four bacteria (Erwinia carotovora (Ec), Clavibacter species, Bacillus subtillis, and Pseudomonas syringe pv. Phaseolicola) were isolated and identified to be responsible for the potato rot. The severity of rot induced by the bacteria ranged between 39.77 and 46.34%. Distemonanthus benthamianus extract (at 500- 1500mg/ml) significantly (p<0.05) produced the highest antibacterial property in vitro against the four bacterial isolates, followed by Zz whereas the other explants showed no bacteriotoxic property except Mo against Ec only at 1500mg/ml. Distemonanthus benthamianus, next to Erythromycin (antibiotics), produced higher inhibition zones (5.0±0-9.3±3.1mm) on all the bacteria isolates than all other explants and significantly inhibited rot development in potato in vivo. The high antimicrobial potential of D. benthamianus against postharvest bacterial tuber rot of potato suggests a safe biopesticide for postharvest potato disease management

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Malan, Elfranco, e Silverkanabathi Naidoo. "A hexa-substituted flavonol from Distemonanthus benthamianus". Phytochemistry 29, n.º 7 (janeiro de 1990): 2366. http://dx.doi.org/10.1016/0031-9422(90)83079-g.

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Malan, Elfranco. "A flavonol with a tetrasubstituted B-ring from Distemonanthus benthamianus". Phytochemistry 32, n.º 6 (janeiro de 1993): 1631–32. http://dx.doi.org/10.1016/0031-9422(93)85198-z.

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Aiyegoro, O. A., D. A. Akinpelu, A. J. Afolayan e A. I. Okoh. "Antibacterial Activities of Crude Stem Bark Extracts of Distemonanthus benthamianus Baill". Journal of Biological Sciences 8, n.º 2 (1 de fevereiro de 2008): 356–61. http://dx.doi.org/10.3923/jbs.2008.356.361.

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Shittu, AO, A. Aliyu, MS David, NS Njinga e HI Ishaq. "Potential Antibacterial Activity of Two Important Local Chewing Sticks “Fagara zanthoxyloides and Distemonanthus benthamianus” along with Antioxidant Capacities". Dhaka University Journal of Pharmaceutical Sciences 18, n.º 2 (12 de dezembro de 2019): 223–32. http://dx.doi.org/10.3329/dujps.v18i2.44462.

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In order to authenticate and ascertain the various claim by the rural dwellers that depend on chewing sticks for their oral hygiene and protection against innumerable diseases, the antibacterial activity of the roots of Fagara zanthoxyloides and Distemonanthus benthamianus were evaluated. Preliminary phytochemical screening was carried out using standard methods. In-vitro antibacterial activity of the methanol extracts of both plants was also carried out using the agar well diffusion method against standard strains of Staphylococcus aureus ATCC 25923, Pseudomonas aeruginosa ATCC 27853, Escherichia coli ATCC 25922, Salmonella typhii ATCC 14028, Citrobacter freundii ATCC 8090 and also some clinical isolates of Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis at different concentrations and ratios. Preliminary phytochemical screening showed that the extracts contained alkaloids, saponin, tannins, steroids, flavonoids, anthraquinones, cardiac glycosides and phenol. All the test microorganisms were susceptible to the inhibitory effect of the extracts at concentrations of 200 mg/ml and 500 mg/ml. F. zanthoxyloides had better antimicrobial activity with zones of inhibition ranging from 21.0 to 26.0 mm at 200 mg/ml and 24.3 to 29.3 mm at 500 mg/ml while D. benthamianus had zones of inhibition ranging from 17.7 to 26.7 mm at 200 mg/mL and 19.0 to 26.7 mm at 500 mg/mL. Some of the test microorganisms were resistant to the standard antibiotics (cefuroxime, ciprofloxacin, ofloxacin and gentamicin). Combinations of the extracts in ratios 50:50 and 75:25 yielded no increase in activity. The MIC and MBC for D. benthamianus ranged from 6.25 mg/ml to 100 mg/mL and 25 to 200 mg/ml, respectively while that of F. zanthoxyloides ranged from 1.56 mg/ml to 12.5 mg/mL and 50 to 200 mg/ml, respectively. The antimicrobial activity demonstrated by F. zanthoxyloides and D. benthamianus indicates that they would be valuable in the management of urinary, respiratory and gastrointestinal tracts infections while at the same time helping to mitigate the problem of antimicrobial resistance. Phenolic compounds of plants, among them flavonoids are the chief constituents, which have potent antioxidant activities Dhaka Univ. J. Pharm. Sci. 18(2): 223-232, 2019 (December)

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Femi Oyewo, Mbang, Olutayo Adeleye, Caroline Babalola, Olufemi Banjo, Modupe Adebowale e Florence Odeleye. "In vitro evaluation of antimicrobial activity of Distemonanthus benthamianus chewing stick extract mouthwash". İstanbul Journal of Pharmacy 51, n.º 1 (30 de abril de 2021): 105–10. http://dx.doi.org/10.26650/istanbuljpharm.2020.0058.

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Kepdieu Tchebou, Robert V., Paul Eckhardt, Blondelle Matio Kemkuignou, Roland Tchuenguem, Romuald Tematio Fouedjou, Beaudelaire Kemvoufo Ponou, Jean Paul Dzoyem et al. "A dinorcassane-type diterpene and a steroidal saponin from Distemonanthus benthamianus Baill. (Caesalpiniaceae)". Phytochemistry Letters 48 (abril de 2022): 62–67. http://dx.doi.org/10.1016/j.phytol.2022.02.001.

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Marius, Mbiantcha, YousseuNana William, KwentehErnest Allah Hoki, Ateufack Gilbert, TsafackEric Gonzal, DjuichouNguemnang Stephanie Flore, FagniNjoya Zenab Linda et al. "Anti-arthritic effect of Distemonanthus benthamianus extracts against rheumatoid arthritis in rats". Asian Pacific Journal of Tropical Biomedicine 12, n.º 10 (2022): 411. http://dx.doi.org/10.4103/2221-1691.357740.

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Ateufack, Gilbert, William Yousseu Nana, Marius Mbiantcha, Shamim Khan, Hafiz Majid Rasheed, Albert Atsamo, AbdulJabbar Shah, Albert Kamanyi e Taous Khan. "Antidiarrheal potential of Distemonanthus benthamianus Baillon. extracts via inhibiting voltage-dependent calcium channels and cholinergic receptors". Asian Pacific Journal of Tropical Biomedicine 9, n.º 11 (2019): 449. http://dx.doi.org/10.4103/2221-1691.270977.

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Alaribe, Chinwe S., Akolade R. Oladipupo, Anjola T. Adebesin, Omolayomi Kaska e Emuejevoke T. Toye. "Phytochemicals, Acute Toxicity and Genotoxicity of Chewing Sticks from Zanthoxylum zanthoxyloides Root and Distemonanthus benthamianus Stem". Bulletin of Faculty of Pharmacy Cairo University 60, n.º 1 (7 de julho de 2022): 1–6. http://dx.doi.org/10.54634/2090-9101.1027.

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Ayisi, Felix, Caleb Nketia Mensah e Lawrence Sheringham Borquaye. "Antiplasmodial potential and safety evaluation of the ethanolic stem bark extract of Distemonanthus benthamianus Baill. (Leguminosae)". Scientific African 12 (julho de 2021): e00809. http://dx.doi.org/10.1016/j.sciaf.2021.e00809.

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Mebude, O., B. Adeniyi e T. Lawal. "In vitro Antimicrobial Activities of Ethanol Extract of Distemonanthus benthamianus (Aayan) Baillon (Fabaceae) on Streptococcus mutans". British Journal of Medicine and Medical Research 22, n.º 1 (10 de janeiro de 2017): 1–8. http://dx.doi.org/10.9734/bjmmr/2017/26954.

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William, Yousseu Nana, Ateufack Gilbert, Abdul Jabbar Shah, Mbiantcha Marius, Tchoumba Tchoumi Liliane Mireille, Matah Mba Marthe Vanessa, Adjouzem Carine Flore et al. "Extracts from the trunk bark of Distemonanthus benthamianus Baillon. (Caesalpiniaceae) developed antidiarrhoeal activities in rats and mice". Oriental Pharmacy and Experimental Medicine 19, n.º 4 (23 de julho de 2019): 421–33. http://dx.doi.org/10.1007/s13596-019-00385-x.

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Borges, Luisa M. S., Simon M. Cragg, Julien Bergot, John R. Williams, Ben Shayler e Gervais S. Sawyer. "Laboratory screening of tropical hardwoods for natural resistance to the marine borer Limnoria quadripunctata: The role of leachable and non-leachable factors". Holzforschung 62, n.º 1 (1 de janeiro de 2008): 99–111. http://dx.doi.org/10.1515/hf.2008.015.

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AbstractThe marine borerLimnoriaingests essential wood components including the extractives the wood contains. Some extractives may confer borer resistance on certain timbers. Feeding byLimnoriacorrelates with the rate of production of faecal pellets. The faecal pellet production rate and mortality on over 40 test timbers and non-resistantPinus sylvestrissapwood was measured over 15 days. By placing animals in leachate from wood and with wood in flowing seawater, the effects of leaching-resistant and water-soluble compounds were measured. Some previously untested timbers affectedLimnoriaas strongly as timbers reputed for durability in marine construction. Wood ofMinquartia guianensis,Nectandra rubraandBruguiera gymnorhizacaused high mortality, and pellet production on them was less than 10% of production onP. sylvestris. Suppressed feeding rates, but with no heavy mortality, were observed on known durable species such asChlorocardium rodiei,Dicorynia guianensis, Lophira alataandNauclea trillesii, but also onCynometra ananta,Distemonanthus benthamianus,Enterolobium schomburgkii,Goupia glabra,Hymenaea courabil,Mammea africana,Shoreasp. andSacoglottis guianensis. Leachate fromB. gymnorhiza,G. glabra,H. coubaril,N. rubraandShoreasp. caused high mortality. These short-term bioassays thus detected clear differences between wood species in their resistance toLimnoriathat matched findings from long-term marine trials, while indicating new species worthy of detailed testing.

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Debout, G. D. G., J.-L. Doucet e O. J. Hardy. "Population history and gene dispersal inferred from spatial genetic structure of a Central African timber tree, Distemonanthus benthamianus (Caesalpinioideae)". Heredity 106, n.º 1 (14 de abril de 2010): 88–99. http://dx.doi.org/10.1038/hdy.2010.35.

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Zaremski, Alba, Marc Ducousso, Odile Domergue, Joel Fardoux, Cécile Rangin, Daniel Fouquet, Hélène Joly, Christian Sales, Bernard Dreyfus e Yves Prin. "In situ molecular detection of some white-rot and brown-rot basidiomycetes infecting temperate and tropical woods". Canadian Journal of Forest Research 35, n.º 5 (1 de maio de 2005): 1256–60. http://dx.doi.org/10.1139/x05-056.

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Wood-decay white-rot and brown-rot fungi have a major economic impact on commercial and manufactured tropical and temperate woods. The aim of this study was to design a molecular method, coupled with polymerase chain reaction (PCR) and DNA sequencing, to enable early identification of various forms of fungal decay in various types of wood. The resulting tool could be used to certify the healthiness of commercial woods and also to make more efficient use of chemicals and thus reduce their negative environmental impact. Sapwood plates of Distemonanthus benthamianus,Fagus sylvatica, Lophira alata, Pinus sylvestris, and Pycnanthus angolensis were incubated in vitro in the presence of Fibroporia vaillantii, Coniophora puteana, Gloeophyllum trabeum, Pycnoporus sanguineus, and Trametes versicolor according to the EN 113 standard method. Average mass losses ranging from 2.6% to 25.0% indicated that all wood samples had been actually infected and enabled us to test the reliability of our method. PCR products were obtained in 24 of 25 combinations, and DNA sequences were obtained in 21 of the 24 fungal PCR products. DNA sequences obtained from infected wood were compared with sequences from pure strains, thus confirming the identity of the infecting strains with 100% similarity for an average of 412 bp.

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N'dri Ange, Konan Gbê Kouakou, Ouattara Sitapha, Kanga Yao, Monney Yapo Urbain e Kra Adou Koffi Mathieu. "Evaluation of the Antifungal Activity of Five Medicinal Plants on the In vitro Growth of a Multi-resistant Strain of Candida albicans". European Scientific Journal, ESJ 19, n.º 3 (31 de janeiro de 2023): 110. http://dx.doi.org/10.19044/esj.2023.v19n3p110.

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This paper focuses on determining the antifungal potential of plants traditionally used to treat infections. Five (5) plants were collected. The anti-Candida albicans activity was evaluated by the double dilution method in tilted tubes with the aqueous and hydroethanolic extracts of the different plants. The results showed that 70% ethanolic extracts were more active than the aqueous extracts for all the plants. The 70% ethanolic extract of Terminalia ivorensis (MFC = 1.56 mg/mL) was the most active on the tested strain. This was followed by Terminalia Superba (MFC = 3.125 mg/mL), Distemonanthus benthamianus (MFC = 50 mg/mL), Gmelina arborea (MFC= 50 mg/mL), and Justicia secunda (MFC ˃ 50 mg/mL). The phytochemical screening revealed the presence of seven (7) major groups of compounds. Saponosides are present only in the aqueous extracts of plants. Polyphenols, Flavonoids, Polyterpenes, and Sterols as well as Tanins are present in both alcoholic and aqueous extracts. These compounds could justify its activity and its traditional use. The interesting results obtained with the hydroethanolic extract of Terminalia ivorensis incite further research with this extract. A bio-guided study on the fractions from this extract could lead to the discovery of one or more molecules of interest in the fight against pathogenic fungi.

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Gan, Han Ming, Bolaji N. Thomas, Nicole T. Cavanaugh, Grace H. Morales, Ashley N. Mayers, Michael A. Savka e André O. Hudson. "Whole genome sequencing of Rhodotorula mucilaginosa isolated from the chewing stick (Distemonanthus benthamianus): insights into Rhodotorula phylogeny, mitogenome dynamics and carotenoid biosynthesis". PeerJ 5 (14 de novembro de 2017): e4030. http://dx.doi.org/10.7717/peerj.4030.

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In industry, the yeast Rhodotorula mucilaginosa is commonly used for the production of carotenoids. The production of carotenoids is important because they are used as natural colorants in food and some carotenoids are precursors of retinol (vitamin A). However, the identification and molecular characterization of the carotenoid pathway/s in species belonging to the genus Rhodotorula is scarce due to the lack of genomic information thus potentially impeding effective metabolic engineering of these yeast strains for improved carotenoid production. In this study, we report the isolation, identification, characterization and the whole nuclear genome and mitogenome sequence of the endophyte R. mucilaginosa RIT389 isolated from Distemonanthus benthamianus, a plant known for its anti-fungal and antibacterial properties and commonly used as chewing sticks. The assembled genome of R. mucilaginosa RIT389 is 19 Mbp in length with an estimated genomic heterozygosity of 9.29%. Whole genome phylogeny supports the species designation of strain RIT389 within the genus in addition to supporting the monophyly of the currently sequenced Rhodotorula species. Further, we report for the first time, the recovery of the complete mitochondrial genome of R. mucilaginosa using the genome skimming approach. The assembled mitogenome is at least 7,000 bases larger than that of Rhodotorula taiwanensis which is largely attributed to the presence of large intronic regions containing open reading frames coding for homing endonuclease from the LAGLIDADG and GIY-YIG families. Furthermore, genomic regions containing the key genes for carotenoid production were identified in R. mucilaginosa RIT389, revealing differences in gene synteny that may play a role in the regulation of the biotechnologically important carotenoid synthesis pathways in yeasts.

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Asamoah, A., K. Frimpong-Mensah e C. Antwi-Boasiako. "Efficacy of Tectona grandis (Teak) and Distemonanthus benthamianus (Bonsamdua) Water Extractives on the Durability of Five Selected Ghanaian Less Used Timber Species". Pakistan Journal of Chemistry 1, n.º 1 (30 de março de 2011): 28–31. http://dx.doi.org/10.15228/2011.v01.i01.p05.

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Asamoah, A., K. Frimpong-Mensah e C. Antwi-Boasiako. "Efficacy of Erythropleum suaveolens (potrodom) and Distemonanthus benthamianus (bonsamdua) Water Extractives on the Durability of Five Selected Ghanaian Less Used Timber Species". Pakistan Journal of Chemistry 3, n.º 2 (30 de junho de 2013): 48–50. http://dx.doi.org/10.15228/2013.v03.i02.p01.

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Saha Tchinda, Jean-Bosco, Anélie Pétrissans, Stéphane Molina, Maurice Kor Ndikontar, Steeve Mounguengui, Stéphane Dumarçay e Philippe Gérardin. "Study of the feasibility of a natural dye on cellulosic textile supports by red padouk (Pterocarpus soyauxii) and yellow movingui (Distemonanthus benthamianus) extracts". Industrial Crops and Products 60 (setembro de 2014): 291–97. http://dx.doi.org/10.1016/j.indcrop.2014.06.029.

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Obiang, CédricSima, RickLéonid Ngoua Meye Misso, GuyRoger Ndong Atome, JosephPrivat Ondo, LouisClément Obame Engonga e EdouardNsi Emvo. "Phytochemical analyses, antimicrobial and antioxidant activities of stem bark extracts of Distemonanthus benthamianus H. Baill. and fruit extracts of Solanum torvum Sw. from Gabon". Asian Pacific Journal of Tropical Biomedicine 9, n.º 5 (2019): 209. http://dx.doi.org/10.4103/2221-1691.259001.

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Demenou, Boris B., Rosalía Piñeiro e Olivier J. Hardy. "Origin and history of the Dahomey Gap separating West and Central African rain forests: insights from the phylogeography of the legume tree Distemonanthus benthamianus". Journal of Biogeography 43, n.º 5 (9 de janeiro de 2016): 1020–31. http://dx.doi.org/10.1111/jbi.12688.

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Asamoah, A., K. Frimpong-Mensah e C. Antwi-Boasiako. "Efficacy of Erythropleum suaveolens (potrodom) and Distemonanthus benthamianus (bonsamdua) water extractives on the durability of five Ghanaian less used timber species of varying perviousness and retentiveness". Journal of the Indian Academy of Wood Science 11, n.º 1 (junho de 2014): 72–81. http://dx.doi.org/10.1007/s13196-014-0120-4.

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Fatou Shcherazade, Ouattara-Soro, Kouadio Kouakou John, Yao Konan Bertin, Thanon Mariam e Abizi Georges. "In Vitro Antioxidant and Anti-arthritic Activity of the Aqueous Extract of the Bark of <i>Distemonanthus benthamianus</i> (Caesalpiniaceae) on Wistars Rats". American Journal of BioScience 9, n.º 2 (2021): 55. http://dx.doi.org/10.11648/j.ajbio.20210902.14.

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Saha, Jean-Bosco Tchinda, Daouda Abia, Stéphane Dumarçay, Maurice Kor Ndikontar, Philippe Gérardin, Joseph Ngamveng Noah e Dominique Perrin. "Antioxidant activities, total phenolic contents and chemical compositions of extracts from four Cameroonian woods: Padouk (Pterocarpus soyauxii Taubb), tali (Erythrophleum suaveolens), moabi (Baillonella toxisperma), and movingui (Distemonanthus benthamianus)". Industrial Crops and Products 41 (janeiro de 2013): 71–77. http://dx.doi.org/10.1016/j.indcrop.2012.04.012.

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"Distemonanthus benthamianus". CABI Compendium CABI Compendium (7 de janeiro de 2022). http://dx.doi.org/10.1079/cabicompendium.19273.

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Kouadio, K. J., F. S. Ouattara-Soro, W. M. O. Tovi, K. B. Yao, M. GboGbo, T. B. L. Aboli, G. Abizi, K. E. Begbin e A. Kone. "Study of the Acute Toxicity and Antipyretic Activity of the Aqueous Extract of the Bark Distemonanthus benthamianus Baill (Caesalpiniaceae: Leguminosae -Caesalpinioideae)". European Journal of Medicinal Plants, 31 de dezembro de 2020, 48–58. http://dx.doi.org/10.9734/ejmp/2020/v31i1930349.

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Aims: Distemonanthus benthamianus is a widespread plant in West Africa. The bark of its stem is used popularly to treat a variety of illnesses, including fever, bronchitis, rheumatism and malaria. The objective of this work is to evaluate the antipyretic activity of the aqueous extract of the bark of Distemonanthus benthamianus. Materials and Methods: The aqueous extract of the bark of D. benthamianus was tested for their acute oral toxicity in rats. Antipyretic activity was studied in rats of the Wistar strain made feverish after subcutaneous injection of an aqueous suspension of brewer's yeast (Saccharomycete cerevisiae) 20% compared to aspirin. Results: This study showed that administration of the extract at doses of 300, 2000 and 5000 mg / kg / kg dry extract in rats showed no acute toxicity or adverse effects. The results showed that the best antipyretic activity of the extract was recorded at a dose of 800 mg / kg, at the third hour, with a decrease in fever from 39.29 ± 0.14°C to 37.75 ± 0.25°C, i.e. a percentage inhibition of 57% against 62% for the standard molecule (p> 0.05). At this dose, CRP was 3.85 ± 0.1 mg / L compared to that of the healthy control which was 2.78 ± 0.35 mg / L. The results of the albumin assay did not show a significant difference between the treated and untreated fever groups and the healthy control group. In addition, the results showed that the leukocyte level in the feverish control rats is very high (18.84 103 / mm3 of leukocytes) compared to the healthy and treated control rats. Conclusion: The aqueous extract of the bark of Distemonanthus benthamianus is not oral toxic and has interesting antipyretic activities similar to aspirin. The results obtained confirm the validity of the traditional indication of this plant in the management of fever by African populations.

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Gan, Han Ming, Anutthaman Parthasarathy, Kurtis R. Henry, Michael A. Savka, Bolaji N. Thomas e André O. Hudson. "Whole-Genome Sequencing of Pantoea sp. Strain RIT388, a Potential Oral Opportunistic Pathogen Isolated from a Chewing Stick (Distemonanthus benthamianus)". Microbiology Resource Announcements 9, n.º 9 (27 de fevereiro de 2020). http://dx.doi.org/10.1128/mra.01468-19.

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In this study, we report the isolation, identification, characterization, and whole-genome sequence of the endophyte Pantoea sp. strain RIT388, isolated from Distemonanthus benthamianus, a plant known for its antifungal and antibacterial properties that is commonly used for chewing sticks.

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Matah Marthe, Vanessa Mba, Gilbert Ateufack, Marius Mbiantcha, William Yousseu Nana, Albert Donatien Atsamo, Flore Carine Adjouzem, Flore Stephanie Djuichou Nguemnang, Gonzal Eric Tsafack, Herve Tchoumbou Tadjoua e Joseph Emakoua. "Cytoprotective and antisecretory properties of methanolic extract of Distemonanthus benthamianus (Caesalpiniaceae) stem bark on acute gastric ulcer in rats". Journal of Complementary and Integrative Medicine, 25 de julho de 2020. http://dx.doi.org/10.1515/jcim-2019-0216.

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AbstractObjectivesIn African traditional medicine, Distemonanthus benthamianus (Caesalpiniaceae) is used to treat many diseases including gastric ulcers. We evaluated in this study, the cytoprotective and antisecretory properties of the methanolic extract of the stem bark of this plant using different technics of gastric lesion induction.MethodsCytoprotective and antisecretory activity of the methanolic extract of D. benthamianus stem bark was evolved through six methods of gastric lesion induction in experimental Wistar male rats (150–200 g): (1) gastric lesions induced by HCl/ethanol, (2) gastric lesions induced by Indomethacin- HCl/ethanol, (3) gastric lesion induced by Indomethacin, (4) gastric lesions induced by Pylorus ligation, (5) gastric lesions induced by histamine-Pylorus ligation, (6) gastric lesions induced by carbachol-Pylorus ligation. Mucus and gastric mucosal ulceration were evaluated. pH, gastric volume, and acidity were quantified in all pylorus ligation induction technics. Nitric oxide (NO) level was determined in indomethacin induced gastric ulcers.ResultsAt different doses (125, 250 and 500 mg/kg), extract reduced significantly the ulcer index. In all models used, that is 100.00% with HCl/ethanol; 100.00% with HCl/ethanol/indomethacin; 95.70% with Indomethacin; 74.79% with pylorus ligation, 95.94% histamine-Pylorus ligation, 99.54% carbachol-Pylorus ligation at the highest dose of 500 mg/kg. The lesion formation reduces in all the methods used followed by a significant increase of mucus production. The pylorus ligation technic revealed that the extract has an antisecretory activity.ConclusionsThe methanolic extract of D. benthamianus stem bark has both cytoprotective and antisecretory effects. This extract exerts its antisecretory effect trough cholinergic and histaminergic pathways.

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William, Yousseu Nana, Ateufack Gilbert, Abdul Jabbar Shah, Fazli Wahid, Mbiantcha Marius, Muhammad Arfat Yameen, Syed Luqman Shah et al. "Curative effects of Distemonanthus benthamianus Baillon. Trunk-bark extracts on enteropathogenic Escherichia coli 31-induced diarrhea in rats". Journal of Complementary and Integrative Medicine 16, n.º 4 (23 de maio de 2019). http://dx.doi.org/10.1515/jcim-2018-0202.

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Abstract Background Distemonanthus benthamianus is used in the Western part of Cameroon to treat diarrheal episodes and infections. This study assessed its trunk-bark extracts activity against enteropathogenic Escherichia coli 31 (EPEC 31)-induced diarrhea in rats. Methods Aqueous and methanolic extracts were analyzed through high-performance liquid chromatography (HPLC). In vitro minimum inhibitory and bactericidal concentrations (MICs/MBCs) were evaluated on Enterococcus faecalis (ATCC 10,541), E. coli (ATCC 6539), Klebsiella pneumoniae (ATCC 13,883), Salmonella typhi (ATCC 6539) strains and on Proteus mirabilis, Pseudomonas aeruginosa (PA 01) and Shigella flexneri isolates using the microdilution method. Diarrhea was induced by inoculating rats with EPEC 31 (1.5 × 108 CFU/mL; p.o). Serum transaminases level assay and enzyme-linked immunosorbent assay (ELISA) for cytokines determination were performed. Hematoxylin–eosin (H–E) staining was used for intestinal tissue analysis. Results HPLC fingerprints of extracts showed presence of gallic acid and other unidentified compounds. The lowest MIC of 256 µg/mL was obtained with methanolic extract. At 100 mg/kg, both extracts significantly (p<0.001) inhibited diarrhea, with the methanolic extract being the most active. In addition, the methanolic extract significantly (p<0.001) increased the relative mass of the liver compared to negative control (Tween-DMSO 8%). The aqueous extract (100 mg/kg) significantly (p<0.01) increased alanine aminotransferase (ALT) serum concentration; while the methanolic extract (100 mg/kg) exhibited similar effect over aspartate aminotransferase (AST). At 50 and 100 mg/kg, the methanolic extract significantly (p<0.05 and p<0.01) decreased the Interleukin-1β (IL-1β) serum level, compared to negative control (Tween-DMSO 8%). Serum level of tumor necrosis factor alpha (TNF-α) significantly (p<0.001) decreased with 100 mg/kg of aqueous extract and all doses of methanolic extract. Inhibition of inflammatory cells tissue infiltration and epithelial regeneration was highly noticed in the ileum and colon of extracts-treated rats than in ciprofloxacin-treated animals. Conclusion These findings suggest that D. benthamianus trunk-bark extracts displayed therapeutic effects against infectious diarrhea in rats.

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John, Kouadio Kouakou, Ouattara-Soro Fatou Shcherazade, Abizi Georges, Zougrou N’guessan Ernest, Kouakou Koffi Roger, Begbin Kouassi Emile, Kplé Tatiana Kangah Mireille, Kablan Kassi Jean-Jacques e Koffi Severin. "Activité Anti-Inflammatoire Et Études Phytochimiques De L’extrait Aqueux Des Écorces Distemonanthus Benthamianus Baill. (Caesalpiniaceae : Leguminosae - Caesalpinioideae)". European Scientific Journal ESJ 17, n.º 7 (28 de fevereiro de 2021). http://dx.doi.org/10.19044/esj.2021.v17n7p74.

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Distemonanthus benthamianus est une plante utilisée en médecine traditionnelle dans certains pays Africains tels que : la Côte d’Ivoire, le Ghana, le Cameroun etc. Plusieurs études ont été réalisées relatives à son effet sur les activités antioxydante, antitumorale, antituberculeuse, bactéricide, antivirale. L’objectif de ce travail a été d’évaluer in vivo l’activité anti-inflammatoire de l’extrait total aqueux des écorces de cette plante. Pour atteindre cet objectif, le screening phytochimique a été réalisé afin de déterminer les métabolites secondaires présentent dans l’extrait de la plante. L’activité antiinflammatoire a été évalué par l’ingestion de la carragénine 1% au niveau l’aponévrose plantaire des rats Wistars. Le screening phytochimique a révélé la présence de tanins, polyphénols, flavonoïdes, saponosides, de triterpènes et d’alcaloïdes Les résultats de l’activité anti-inflammatoire ont montré que le diclofénac et l’extrait aqueux de la plante ont atteint leur activité maximale d’inhibition de l’œdème à la 3ème heure avec une inhibition de 52.88 %, et 44.95%, 60.03% et 70.19 aux doses de 200, 400 et 800mg/kg/pc respectivement. Quant à la prednisone, il a atteint son activité maximale de 26.66% à la 4ème heure. L’inhibition de l’œdème des pattes des rats par l’extrait de la plante montre ainsi les propriétés anti-inflammatoires de cet extrait. L’utilisation de cette plante comme un anti-inflammatoire en milieu naturel serait donc justifiée.

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Nguelefack, Elvine MP, Kathleen B. Ngu, Alex Atchade, Théophile Dimo, Nole Tsabang e Joseph T. Mbafor. "Phytochemical composition and in vitro effects of the ethyl acetate bark extract of Distemonanthus benthamianus Baillon (Caesalpiniaceae) on Staphylococcus aureus and Streptococcus agalactiae". Cameroon Journal of Experimental Biology 1, n.º 1 (31 de agosto de 2006). http://dx.doi.org/10.4314/cajeb.v1i1.37927.

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