Literatura científica selecionada sobre o tema "Dibenzocyclooctyne"
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Artigos de revistas sobre o assunto "Dibenzocyclooctyne"
He, Yinming, Li Liu e Liang Cheng. "A Short Review of Research Progress on the Synthesis Approaches of Aza-Dibenzocyclooctyne Derivatives". Molecules 28, n.º 9 (25 de abril de 2023): 3715. http://dx.doi.org/10.3390/molecules28093715.
Texto completo da fonteNarayanam, Maruthi Kumar, Yong Liang, K. N. Houk e Jennifer M. Murphy. "Discovery of new mutually orthogonal bioorthogonal cycloaddition pairs through computational screening". Chemical Science 7, n.º 2 (2016): 1257–61. http://dx.doi.org/10.1039/c5sc03259h.
Texto completo da fonteShenje, Learnmore, Yingqi Qu, Vladimir Popik e Susanne Ullrich. "Femtosecond photodecarbonylation of photo-ODIBO studied by stimulated Raman spectroscopy and density functional theory". Physical Chemistry Chemical Physics 23, n.º 45 (2021): 25637–48. http://dx.doi.org/10.1039/d1cp03512f.
Texto completo da fonteAdronov, Alex, Kelvin Li e Stuart McNelles. "Preparation and Properties of a Hydrolytically Stable Cyclooctyne-Containing Polymer". Synlett 29, n.º 19 (3 de setembro de 2018): 2535–41. http://dx.doi.org/10.1055/s-0037-1610636.
Texto completo da fonteWang, Mengzhe, Christopher D. McNitt, Hui Wang, Xiaofen Ma, Sarah M. Scarry, Zhanhong Wu, Vladimir V. Popik e Zibo Li. "The efficiency of 18F labelling of a prostate specific membrane antigen ligand via strain-promoted azide–alkyne reaction: reaction speed versus hydrophilicity". Chemical Communications 54, n.º 56 (2018): 7810–13. http://dx.doi.org/10.1039/c8cc03999b.
Texto completo da fonteKardelis, Vladimir, Ryan C. Chadwick e Alex Adronov. "Click Functionalization of a Dibenzocyclooctyne-Containing Conjugated Polyimine". Angewandte Chemie International Edition 55, n.º 3 (8 de dezembro de 2015): 945–49. http://dx.doi.org/10.1002/anie.201508639.
Texto completo da fonteKardelis, Vladimir, Ryan C. Chadwick e Alex Adronov. "Click Functionalization of a Dibenzocyclooctyne-Containing Conjugated Polyimine". Angewandte Chemie 128, n.º 3 (8 de dezembro de 2015): 957–61. http://dx.doi.org/10.1002/ange.201508639.
Texto completo da fonteMoran, Joseph, Craig S. McKay e John Paul Pezacki. "Strain-promoted 1,3-dipolar cycloadditions of diazo compounds with cyclooctynes". Canadian Journal of Chemistry 89, n.º 2 (fevereiro de 2011): 148–51. http://dx.doi.org/10.1139/v10-112.
Texto completo da fonteKettenbach, K., e T. L. Ross. "A 18F-labeled dibenzocyclooctyne (DBCO) derivative for copper-free click labeling of biomolecules". MedChemComm 7, n.º 4 (2016): 654–57. http://dx.doi.org/10.1039/c5md00508f.
Texto completo da fonteDjurdjevic, Sinisa, e James R. Green. "Nicholas Reactions in the Synthesis of Dicobalt Dibenzocyclooctyne Complexes". Organic Letters 15, n.º 21 (14 de outubro de 2013): 5468–71. http://dx.doi.org/10.1021/ol402617a.
Texto completo da fonteTeses / dissertações sobre o assunto "Dibenzocyclooctyne"
Cornillot-Clément, Selma. "Développement d’un bio-hybride conjuguant lymphocytes T gamma delta et polymersome : combinaison de la thérapie cellulaire et du drug delivery". Electronic Thesis or Diss., Bordeaux, 2024. http://www.theses.fr/2024BORD0270.
Texto completo da fonteBackground: The combination of cell therapy and nanomedicine has advanced in recent years to improve the management of various pathologies. γδ T lymphocytes (γδ T cells), a cell population at the interface between innate and adaptive immunity, are involved in immune response to infectious agents and to cancers. They are divided into two main subpopulations: Vγ9Vδ2 T cells and non-Vγ9Vδ2 T cells, mainly composed of Vδ1 T cells. Vδ1 T cells have multiple activation mechanisms independent of antigen presentation by HLA and various effector functions, making them particularly attractive for overcoming the limitations associated with therapies that use more conventional populations such as αβ T cells. Additionally, these cells have tissue-targeting properties that make them promising vectors for developing nanoparticle-based therapies. Among the nanoparticles developed in recent years, polymeric nanoparticles, or polymersomes, stand out due to their many attractive features: a membrane with tunable size and composition, significant encapsulation capacity, and relatively simple formulation. Moreover, advances in metabolic engineering and click chemistry using cyclooctynes such as Dibenzocyclooctyne (DBCO) have facilitated their use in the development of new targeted therapies.Objective: This thesis aimed to develop a click chemistry protocol to create a biohybrid composed of DBCO-functionalized polymersomes and Vδ1 T cells (DOT) amplified and modified through metabolic engineering.Results: Initially, metabolic engineering and click chemistry protocols were developed using fluorescent DBCO. These protocols were sequentially optimized on a cell line, peripheral blood mononuclear cells (PBMCs), and then on the cells of interest, the DOT cells. Toxicity and functionality tests were conducted to assess the feasibility of this biohybrid. Subsequently, the same protocol was tested and optimized on DOT cells and empty polymersomes functionalized with DBCO.Perspectives: This thesis provides a first proof of concept for combining polymersomes with DOT cells. However, further validation tests are necessary to fully evaluate the feasibility of this biohybrid. These tests should particularly verify the activity of DOT cells against the target cells, the toxicity associated with click chemistry, and the potential benefits that this new therapeutic approach could offer in treating pathologies such as cancer and CMV infection
Terzic, Vida. "Utilisation de la chimie "click" pour visualiser la pénétration de principes actifs dans les protozoaires parasites". Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLS190/document.
Texto completo da fonteThe discovery of new molecules with antiparasitic activity is crucial today to fight against infectious diseases such as malaria and HAT since no vaccine is available to cure these diseases. In our search for new antiparasitic compounds, we observed that activity improvement on an isolated target was not seen on parasite. We suspected an ineffective entry of the molecule into the cell to be one of the reasons for these uncorrelated results.To explore this possibility, this PhD work aimed to design, synthetize and evaluate new fluorescent probes that would allow the visualization of drug entry into parasites responsible for HAT and malaria.Our concept is based on “click” chemistry that can be achieved without catalyst, between an azide and a strained alkyne like cyclooctyne (Strain-Promoted Alkyne-Azide Cycloaddition).We synthetized derivatives of dibenzocyclooctynone, a fluorescent molecule described to undergo SPAAC reaction with azides, in order to obtain “on-on’” detection probes. Seven new fluorescent probes were therefore synthetized, among which three of them displayed adequate SPAAC kinetics. Photophysical properties of these molecules were characterized and their penetration into protozoan cells was demonstrated. Fluorescence was only observed in the parasitic cytosol.In cellulo azide detection was achieved and verified by LC- MS/MS with one of our probes.One out of the seven probes formed a fluorescent triazole adduct, which constitutes the first example of an « on-on’ » probe for this series and a real progress in bioorthogonal chemistry
Capítulos de livros sobre o assunto "Dibenzocyclooctyne"
Kern, Michael, e Sébastien Ferreira-Cerca. "Differential Translation Activity Analysis Using Bioorthogonal Noncanonical Amino Acid Tagging (BONCAT) in Archaea". In Ribosome Biogenesis, 229–46. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2501-9_14.
Texto completo da fonte