Literatura científica selecionada sobre o tema "DGKκ"
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Artigos de revistas sobre o assunto "DGKκ"
Gravina, Teresa, Chiara Maria Teresa Boggio, Elisa Gorla, Luisa Racca, Silvia Polidoro, Sara Centonze, Daniela Ferrante et al. "Role of Diacylglycerol Kinases in Acute Myeloid Leukemia". Biomedicines 11, n.º 7 (1 de julho de 2023): 1877. http://dx.doi.org/10.3390/biomedicines11071877.
Texto completo da fonteTabet, Ricardos, Enora Moutin, Jérôme A. J. Becker, Dimitri Heintz, Laetitia Fouillen, Eric Flatter, Wojciech Krężel et al. "Fragile X Mental Retardation Protein (FMRP) controls diacylglycerol kinase activity in neurons". Proceedings of the National Academy of Sciences 113, n.º 26 (27 de maio de 2016): E3619—E3628. http://dx.doi.org/10.1073/pnas.1522631113.
Texto completo da fonteYAMADA, Keiko, Fumio SAKANE, Norio MATSUSHIMA e Hideo KANOH. "EF-hand motifs of α, β and γ isoforms of diacylglycerol kinase bind calcium with different affinities and conformational changes". Biochemical Journal 321, n.º 1 (1 de janeiro de 1997): 59–64. http://dx.doi.org/10.1042/bj3210059.
Texto completo da fonteBaldanzi, Gianluca, e Mario Malerba. "DGKα in Neutrophil Biology and Its Implications for Respiratory Diseases". International Journal of Molecular Sciences 20, n.º 22 (13 de novembro de 2019): 5673. http://dx.doi.org/10.3390/ijms20225673.
Texto completo da fonteGharbi, Severine I., Esther Rincón, Antonia Avila-Flores, Pedro Torres-Ayuso, María Almena, María Angeles Cobos, Juan Pablo Albar e Isabel Mérida. "Diacylglycerol kinase ζ controls diacylglycerol metabolism at the immunological synapse". Molecular Biology of the Cell 22, n.º 22 (15 de novembro de 2011): 4406–14. http://dx.doi.org/10.1091/mbc.e11-03-0247.
Texto completo da fonteKatagiri, Yuji, Tsukasa Ito, Sachiko Saino-Saito, Yasukazu Hozumi, Akira Suwabe, Kazuhisa Otake, Makoto Sata et al. "Expression and localization of diacylglycerol kinase isozymes and enzymatic features in rat lung". American Journal of Physiology-Lung Cellular and Molecular Physiology 288, n.º 6 (junho de 2005): L1171—L1178. http://dx.doi.org/10.1152/ajplung.00237.2004.
Texto completo da fonteTopham, Matthew K., e Stephen M. Prescott. "Diacylglycerol Kinase ζ Regulates Ras Activation by a Novel Mechanism". Journal of Cell Biology 152, n.º 6 (12 de março de 2001): 1135–44. http://dx.doi.org/10.1083/jcb.152.6.1135.
Texto completo da fonteROCHE, Marc A. de la, Janet L. SMITH, Maribel RICO, Silvia CARRASCO, Isabel MERIDA, Lucila LICATE, Graham P. CÔTÉ e Thomas T. EGELHOFF. "Dictyostelium discoideum has a single diacylglycerol kinase gene with similarity to mammalian θ isoforms". Biochemical Journal 368, n.º 3 (15 de dezembro de 2002): 809–15. http://dx.doi.org/10.1042/bj20021027.
Texto completo da fonteDU, Xiangnan, Ying JIANG, Weijun QIAN, Xiaolan LU e James P. WALSH. "Fatty acids inhibit growth-factor-induced diacylglycerol kinase α activation in vascular smooth-muscle cells". Biochemical Journal 357, n.º 1 (25 de junho de 2001): 275–82. http://dx.doi.org/10.1042/bj3570275.
Texto completo da fonteDougan, Stephanie K. "Abstract SY12-04: Lowering the TCR signaling threshold with a DGKa/z dual inhibitor potentiates anti-tumor immunity". Cancer Research 83, n.º 7_Supplement (4 de abril de 2023): SY12–04—SY12–04. http://dx.doi.org/10.1158/1538-7445.am2023-sy12-04.
Texto completo da fonteTeses / dissertações sobre o assunto "DGKκ"
Çakil, Oktay. "Regulation of the diacylglycerol kinase kappa (DGKk) by FMRP and its dysregulation in Fragile X Syndrome". Electronic Thesis or Diss., Strasbourg, 2024. http://www.theses.fr/2024STRAJ031.
Texto completo da fonteFragile X syndrome (FXS) is the main cause of inherited intellectual disability and autism. FXS results from the lack of FMRP that leads to aberrant neuronal protein synthesis associated with neurological alterations. The team found that diacylglycerol kinase kappa (DGKκ) is a primary mRNA target of FMRP in cortical neurons. DGKκ is an enzyme regulating lipid signaling whose downregulation upon loss of FMRP could account for several main alterations observed in FXS. We demonstrated that the reexpression of DGKκ into the brains of Fmr1-KO mice using adeno-associated viral vectors provides long-term correction of the core FXS phenotypes. We identified the binding site of FMRP on DGKκ mRNA and underscored the contribution of m6A RNA modifications in FMRP binding to DGKκ mRNA and its translational control. Additionally, we evidenced the contribution of DGKκ to neurological functions by the characterization of the Dgkk-KO mouse model that recapitulates hallmarks of FXS phenotypes. Overall, this study demonstrates the pivotal role of DGKκ in brain functions and its contributions to FXS, and proposes a novel model by which FMRP controls the expression of an mRNA target
Yellenki, Vaibhav. "Role of Diacylglycerol kinase alpha (DGKA) as a therapeutic target in Glioblastoma (GB)". Doctoral thesis, Università del Piemonte Orientale, 2020. http://hdl.handle.net/11579/115034.
Texto completo da fonteVelnati, Suresh. "Development of novel DGKα inhibitors for the treatment of XLP1 and metastatic tumours". Doctoral thesis, Università del Piemonte Orientale, 2020. http://hdl.handle.net/11579/115022.
Texto completo da fonteHeil, Alexandra [Verfasser], e Andreas [Gutachter] Reif. "Assoziation einer DGKH-Risikogenvariante mit phänotypischen Merkmalen bei bipolar-affektiv erkrankten Patienten / Alexandra Heil ; Gutachter: Andreas Reif". Würzburg : Universität Würzburg, 2016. http://d-nb.info/1117477266/34.
Texto completo da fonteFagundes, Gabriela Xavier. "Imunolocalização de células positivas para a enzima diacilglicerol quinase α (DGKα) em polpas de ratos expostas à contaminação". Pontifícia Universidade Católica do Rio Grande do Sul, 2014. http://hdl.handle.net/10923/6678.
Texto completo da fonteIntroduction: Dental pulp is composed of loose connective tissue, which reacts when facing a pathogenic agent, and the inflammation is the first response. DGKα is one of the key enzymes involved on inflammations cellular events. It participates on the neutrophils recruiting to the injury site and on the regulation of superoxide production. The aim of this study was to evaluate the localization of the DGKα in healthy and inflamed/infected dental pulp of rats.Methods: Were used eighteen (18) male Wistar rats. The animals were divided into three groups of six rats each. In Group 1 (control group), no cavity opening was performed. In Groups 2 and 3 dental pulp of the left first molars was exposed to oral environment for 24hours and 7 days respectively. Euthanasia was performed after the experimental periods and the jaws were dissected for histological evaluation and immunodetection of DGKα enzyme.Results: Histological analysis of the dental pulp showed that tissue exposure led to inflammatory and degenerative events, which varied in their extension according to the experimental period of time. In groups 2 and 3, DGKα immunolabeling was observed in neutrophils and abscessed areas, being detected on a greater amplitude of pulp tissue in the 24 hour period.Conclusions: DGKα is expressed on the initial stages of pulp inflammation, although there is no relation with its extent. The understanding of the DGKα role in the pathways of pulp inflammation can help the development of new therapeutic strategies to promote pulp repair.
Introdução: A polpa dentária é formada por um tecido conjuntivo frouxo, que reage frente a um agente agressor patogênico, sendo a inflamação uma de suas manifestações iniciais. A DGKα é uma das enzimas-chave envolvida em eventos celulares da inflamação. A mesma participa do recrutamento de neutrófilos para o local da injúria e da regulação da produção de superóxido. O objetivo deste estudo foi avaliar, em ratos, a localização da DGKα em polpas saudáveis e em polpas inflamadas/infectadas.Metodologia: Foram utilizados dezoito (18) ratos machos Wistar. Os animais foram divididos em três grupos de seis animais cada. No grupo 1 (grupo controle), não foi realizado nenhum procedimento. Nos grupos 2 e 3, a polpa dentária dos primeiros molares do lado esquerdo foi exposta ao meio bucal por 24horas e por 7 dias, respectivamente. A eutanásia foi realizada após os períodos experimentais, e as mandíbulas foram dissecadas para análise histológica e imunolocalização da enzima DGKα.Resultados: A avaliação histológica da polpa dentária mostrou que a exposição tecidual levou a eventos inflamatórios e degenerativos, que variaram de acordo com o período de tempo. Nos grupos 2 e 3, houve marcação da DGKα em neutrófilos e áreas próximas a abscessos, sendo detectada em uma maior amplitude no período de 24 horas.Conclusões: A DGKα é expressa em estágios iniciais da inflamação, não sendo relacionada com a extensão da inflamação pulpar. O entendimento do papel da DGKα na cascata de eventos da inflamação pulpar pode trazer informações para o desenvolvimento de novas estratégias terapêuticas que promovam o reparo pulpar.
Fagundes, Gabriela Xavier. "Imunolocaliza??o de c?lulas positivas para a enzima diacilglicerol quinase ? (DGK?) em polpas de ratos expostas ? contamina??o". Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2014. http://tede2.pucrs.br/tede2/handle/tede/1257.
Texto completo da fonteIntroduction: Dental pulp is composed of loose connective tissue, which reacts when facing a pathogenic agent, and the inflammation is the first response. DGK? is one of the key enzymes involved on inflammations cellular events. It participates on the neutrophils recruiting to the injury site and on the regulation of superoxide production. The aim of this study was to evaluate the localization of the DGK? in healthy and inflamed/infected dental pulp of rats. Methods: Were used eighteen (18) male Wistar rats. The animals were divided into three groups of six rats each. In Group 1 (control group), no cavity opening was performed. In Groups 2 and 3 dental pulp of the left first molars was exposed to oral environment for 24hours and 7 days respectively. Euthanasia was performed after the experimental periods and the jaws were dissected for histological evaluation and immunodetection of DGK? enzyme. Results: Histological analysis of the dental pulp showed that tissue exposure led to inflammatory and degenerative events, which varied in their extension according to the experimental period of time. In groups 2 and 3, DGK? immunolabeling was observed in neutrophils and abscessed areas, being detected on a greater amplitude of pulp tissue in the 24 hour period. Conclusions: DGK? is expressed on the initial stages of pulp inflammation, although there is no relation with its extent. The understanding of the DGK? role in the pathways of pulp inflammation can help the development of new therapeutic strategies to promote pulp repair.
Introdu??o: A polpa dent?ria ? formada por um tecido conjuntivo frouxo, que reage frente a um agente agressor patog?nico, sendo a inflama??o uma de suas manifesta??es iniciais. A DGK? ? uma das enzimas-chave envolvida em eventos celulares da inflama??o. A mesma participa do recrutamento de neutr?filos para o local da inj?ria e da regula??o da produ??o de super?xido. O objetivo deste estudo foi avaliar, em ratos, a localiza??o da DGK? em polpas saud?veis e em polpas inflamadas/infectadas. Metodologia: Foram utilizados dezoito (18) ratos machos Wistar. Os animais foram divididos em tr?s grupos de seis animais cada. No grupo 1 (grupo controle), n?o foi realizado nenhum procedimento. Nos grupos 2 e 3, a polpa dent?ria dos primeiros molares do lado esquerdo foi exposta ao meio bucal por 24horas e por 7 dias, respectivamente. A eutan?sia foi realizada ap?s os per?odos experimentais, e as mand?bulas foram dissecadas para an?lise histol?gica e imunolocaliza??o da enzima DGK?. Resultados: A avalia??o histol?gica da polpa dent?ria mostrou que a exposi??o tecidual levou a eventos inflamat?rios e degenerativos, que variaram de acordo com o per?odo de tempo. Nos grupos 2 e 3, houve marca??o da DGK? em neutr?filos e ?reas pr?ximas a abscessos, sendo detectada em uma maior amplitude no per?odo de 24 horas. Conclus?es: A DGK? ? expressa em est?gios iniciais da inflama??o, n?o sendo relacionada com a extens?o da inflama??o pulpar. O entendimento do papel da DGK? na cascata de eventos da inflama??o pulpar pode trazer informa??es para o desenvolvimento de novas estrat?gias terap?uticas que promovam o reparo pulpar.
Kang, Kiho Paul. "Commandes robustes d'un actionneur synchrone". Grenoble INPG, 1996. http://www.theses.fr/1996INPG0097.
Texto completo da fonteKovalenko, Andrii. "Therapeutic targeting of DGKA-mediated macropinocytosis in lymphangioleiomyomatosis". Thesis, 2020. https://hdl.handle.net/2144/41149.
Texto completo da fonte2021-06-07T00:00:00Z
Heil, Alexandra. "Assoziation einer DGKH-Risikogenvariante mit phänotypischen Merkmalen bei bipolar-affektiv erkrankten Patienten". Doctoral thesis, 2015. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-139051.
Texto completo da fonteA previous study suggested that haplotyp DGKH-GAT can be seen as common risk factor for mood disorders (bipolar disorder, unipolar depression and aADHD). Our aim was to show associations between haplotyp DGKH-GAT and mood symptoms as well as other psychiatric symptoms. We could not find any associations between DGKH-GAT and clinical symptoms
Dias, Sara Melo. "Characterization of a chromosome rearrangement associated with cardiopathy and autism". Master's thesis, 2017. http://hdl.handle.net/10362/27627.
Texto completo da fonteLivros sobre o assunto "DGKκ"
Ontario., Ministry of Culture and Communications., Kenora Field Office. Turtles and tourists: Excavations at the Nestor Falls site (DgK1-3) 1989 and 1990. Thunder Bay: Ministry of Culture and Communication, 1992.
Encontre o texto completo da fonteGermany) Symposium der DGK (14th 2001 Hamburg. Innovative Analytik in der Kosmetik: Proceedings : 14. Symposium der DGK Hamburg, 2001, Deutsche Gesellschaft für Wissenschaftliche und Angewandte Kosmetik e.V. Augsburg: Verlag für chemische Industrie, 2001.
Encontre o texto completo da fonteSchmaltz, Achim A. Erwachsene mit angeborenen Herzfehlern (EMAH): S2-Leitlinie der DGK, DGPK und DGTHG zur Diagnostik und Therapie in Klinik und Praxis ; mit 9 Tabellen. [Heidelberg]: Steinkopff, 2008.
Encontre o texto completo da fonteSchmaltz, Achim A. Erwachsene Mit Angeborenen Herzfehlern: S2-Leitlinie der DGK, DGPK und DGTHG Zur Diagnostik und Therapie in Klinik und Praxis. Steinkopff, Dietrich, 2008.
Encontre o texto completo da fonteCapítulos de livros sobre o assunto "DGKκ"
Gressner, A. M., e O. A. Gressner. "Klinische(r) Chemiker(in) (DGKL)". In Lexikon der Medizinischen Laboratoriumsdiagnostik, 1. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-49054-9_1699-1.
Texto completo da fonteGressner, A. M., e O. A. Gressner. "Klinische(r) Chemiker(in) (DGKL)". In Springer Reference Medizin, 1349. Berlin, Heidelberg: Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-662-48986-4_1699.
Texto completo da fonteGressner, A. M., e O. A. Gressner. "Deutsche Gesellschaft für Klinische Chemie e.V. (DGKC)". In Springer Reference Medizin, 683–84. Berlin, Heidelberg: Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-662-48986-4_863.
Texto completo da fonteGressner, A. M., e O. A. Gressner. "Deutsche Gesellschaft für Klinische Chemie e.V. (DGKC)". In Lexikon der Medizinischen Laboratoriumsdiagnostik, 1. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-49054-9_863-1.
Texto completo da fonteGressner, A. M., e O. A. Gressner. "Deutsche Gesellschaft für Klinische Chemie und Laboratoriumsmedizin e.V. (DGKL)". In Springer Reference Medizin, 684–85. Berlin, Heidelberg: Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-662-48986-4_867.
Texto completo da fonteGressner, A. M., e O. A. Gressner. "Deutsche Gesellschaft für Klinische Chemie und Laboratoriumsmedizin e.V. (DGKL)". In Lexikon der Medizinischen Laboratoriumsdiagnostik, 1–2. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-49054-9_867-1.
Texto completo da fonteShirai, Yasuhito, e Naoaki Saito. "Diacylglycerol Kinase (DGK) as a Regulator of PKC". In Protein Kinase Technologies, 259–71. Totowa, NJ: Humana Press, 2012. http://dx.doi.org/10.1007/978-1-61779-824-5_15.
Texto completo da fonteSchepker, Klaus, e Heiner Fangerau. "Die Gründungsgeschichte der Deutschen Gesellschaft für Kinderpsychiatrie und Heilpädagogik (DGKH) und ihr Wirken". In Kinder- und Jugendpsychiatrie im Nationalsozialismus und in der Nachkriegszeit, 17–186. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-49806-4_2.
Texto completo da fonteArisz, Steven A., e Teun Munnik. "Distinguishing Phosphatidic Acid Pools from De Novo Synthesis, PLD, and DGK". In Methods in Molecular Biology, 55–62. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-401-2_6.
Texto completo da fonte"DGKC". In Springer Reference Medizin, 690. Berlin, Heidelberg: Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-662-48986-4_311015.
Texto completo da fonteTrabalhos de conferências sobre o assunto "DGKκ"
Schweickert, Patrick G., Gabrielle L. Reiner, Casey G. Mitchell, Dana Piovesan, Cesar Meleza, Juan Jose Fung, Ning Wang et al. "1385 Dual Inhibition of DGKα and DGKζ increases T cell and NK cell activity". In SITC 38th Annual Meeting (SITC 2023) Abstracts. BMJ Publishing Group Ltd, 2023. http://dx.doi.org/10.1136/jitc-2023-sitc2023.1385.
Texto completo da fonteWee, Susan, Junchen Gu, Cindy Wang, Carolyn Cao, Sandra Holzhauer, Heshani Desilva, Erin Wesley, Susan Tsai, Douglas Evans e Matthew Riese. "Abstract 936: Regulation of CD8+ T-cell function and antitumor activity by DGKα and DGKζ". In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-936.
Texto completo da fonteWee, Susan, Junchen Gu, Cindy Wang, Carolyn Cao, Sandra Holzhauer, Heshani Desilva, Erin Wesley, Susan Tsai, Douglas Evans e Matthew Riese. "Abstract 936: Regulation of CD8+ T-cell function and antitumor activity by DGKα and DGKζ". In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-936.
Texto completo da fonteVeugen, Thijs. "Improving the DGK comparison protocol". In 2012 IEEE International Workshop on Information Forensics and Security (WIFS). IEEE, 2012. http://dx.doi.org/10.1109/wifs.2012.6412624.
Texto completo da fonteYadav, S., S. S. Shah, S. Pan, B. Singh, T. Kambayashi e D. A. Deshpande. "Diacylglycerol Kinase (DGK) Regulation of Airway Smooth Muscle Contraction". In American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4285.
Texto completo da fonteWang, Adele, Lance Stapleton, Jean-Philippe Belzie, Weimei Xing, Gladys Muiru, Dmytro Kornyeyev, Edward Hsieh et al. "1066 Pharmacologic inhibition of DGKα activates T cells and enhances anti-tumor immunity". In SITC 37th Annual Meeting (SITC 2022) Abstracts. BMJ Publishing Group Ltd, 2022. http://dx.doi.org/10.1136/jitc-2022-sitc2022.1066.
Texto completo da fonteLi, Jie, Chaoyun Pan, Austin C. Boese, Anna Umano e Sumin Kang. "Abstract 4084: A DGKA-cJUN-WEE1 signaling axis provides platinum resistance in ovarian cancer". In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-4084.
Texto completo da fonteBahadori, Milad, e Kimmo Jarvinen. "A Programmable SoC Implementation of the DGK Cryptosystem for Privacy-Enhancing Technologies". In 2020 23rd Euromicro Conference on Digital System Design (DSD). IEEE, 2020. http://dx.doi.org/10.1109/dsd51259.2020.00049.
Texto completo da fonteOffringa, Rienk, Catherine Olesch, Frederik Cichon, Mareike Grees, Norbert Schmees, Ulrike Roehn, Florian Prinz et al. "926 BAY 2965501: a highly selective DGK zeta inhibitor for cancer immunotherapy". In SITC 38th Annual Meeting (SITC 2023) Abstracts. BMJ Publishing Group Ltd, 2023. http://dx.doi.org/10.1136/jitc-2023-sitc2023.0926.
Texto completo da fonteGonzalez, Rachel M., Tianli Qu, Xiaomin Hu, Qi Ren, Qiankun Zhang, Zhaoying Guo, Young-Hwan Kim, Yiran Wang, Xuan Liu e Wei Fu. "Abstract 4985: PD-L1 and diacylglycerol kinase alpha (DGKA) expression in melanoma, nsclc and bladder cancers". In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-4985.
Texto completo da fonte