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Artigos de revistas sobre o tema "Dental repair/regeneration"

Autor: Grafiati

Publicado: 21 de setembro de 2024

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1

Jin, Yiyao, and Ruijie Zeng. "Research on the current situation of regenerative pulp surgery." Highlights in Science, Engineering and Technology 8 (August 17, 2022): 50–53. http://dx.doi.org/10.54097/hset.v8i.1109.

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Regenerative dental pulp therapy uses the principle of biological tissue engineering to replace the damaged dental pulp tissue with living tissue and repair the complex of dental pulp and dentin, so as to restore the normal function of dental pulp dentin structure. For root canal therapy, it is a new type of alternative therapy. In front of it, the treatment is divided into two types: cellular pulp regeneration therapy and acellular pulp regeneration therapy. Cellular regeneration is based on exogenous stem cell transplantation and acellular regeneration is based on endogenous stem cell homing

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Acurio- Cevallos, Sophia Isabella, Emily Estefanía López- Llerena, Rolando Manuel Benites, and Carla Pamela Rodríguez Fiallos. ""Dental regeneration therapy using dental stem cells”." Interamerican Journal of Health Sciences 4 (July 22, 2024): 86. http://dx.doi.org/10.59471/ijhsc202486.

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INTRODUCTION: Regenerative dentistry has undergone significant advances in recent years, and stem cells of dental origin have emerged as a promising therapeutic tool in this field. AIM: To investigate the different types of stem cells of dental origin and to examine their potential application in regenerative therapy in dentistry. METHODOLOGY: A selection of articles published between 2018 and 2023 was performed using the recognized databases Scopus, PubMed, ProQuest, Redalyc, Ovid and Medline. RESULTS: Five main sources of stem cells of dental origin were identified, which have demonstrated t

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Ghosh, Sumanta, Wei Qiao, Zhengbao Yang, Santiago Orrego, and Prasanna Neelakantan. "Engineering Dental Tissues Using Biomaterials with Piezoelectric Effect: Current Progress and Future Perspectives." Journal of Functional Biomaterials 14, no. 1 (2022): 8. http://dx.doi.org/10.3390/jfb14010008.

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Dental caries and traumatic injuries to teeth may cause irreversible inflammation and eventual death of the dental pulp. Nevertheless, predictably, repair and regeneration of the dentin-pulp complex remain a formidable challenge. In recent years, smart multifunctional materials with antimicrobial, anti-inflammatory, and pro-regenerative properties have emerged as promising approaches to meet this critical clinical need. As a unique class of smart materials, piezoelectric materials have an unprecedented advantage over other stimuli-responsive materials due to their inherent capability to genera

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Ghafoor, Robia. "Stem Cell Role in Regenerative Dental Medicine." Annals of Jinnah Sindh Medical University 8, no. 2 (2022): 45–46. http://dx.doi.org/10.46663/ajsmu.v8i2.45-46.

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Regeneration therapies have widely permeated advanced research that aims to reproduce and repair a lost or damaged organ or tissue in order to restore the function and architecture as close to its original state as possible. Tissue engineering refers to the process of regeneration using techniques such as scaffold based cell cultures, stem cell therapy, and biomolecular signaling.

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Mitsiadis, T. A., A. Feki, G. Papaccio, and J. Catón. "Dental Pulp Stem Cells, Niches, and Notch Signaling in Tooth Injury." Advances in Dental Research 23, no. 3 (2011): 275–79. http://dx.doi.org/10.1177/0022034511405386.

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Stem cells guarantee tissue repair and regeneration throughout life. The decision between cell self-renewal and differentiation is influenced by a specialized microenvironment called the ‘stem cell niche’. In the tooth, stem cell niches are formed at specific anatomic locations of the dental pulp. The microenvironment of these niches regulates how dental pulp stem cell populations participate in tissue maintenance, repair, and regeneration. Signaling molecules such as Notch proteins are important regulators of stem cell function, with various capacities to induce proliferation or differentiati

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Ivanov, Alexey A., Alla V. Kuznetsova, Olga P. Popova, Tamara I. Danilova, and Oleg O. Yanushevich. "Modern Approaches to Acellular Therapy in Bone and Dental Regeneration." International Journal of Molecular Sciences 22, no. 24 (2021): 13454. http://dx.doi.org/10.3390/ijms222413454.

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An approach called cell-free therapy has rapidly developed in regenerative medicine over the past decade. Understanding the molecular mechanisms and signaling pathways involved in the internal potential of tissue repair inspires the development of new strategies aimed at controlling and enhancing these processes during regeneration. The use of stem cell mobilization, or homing for regeneration based on endogenous healing mechanisms, prompted a new concept in regenerative medicine: endogenous regenerative medicine. The application of cell-free therapeutic agents leading to the recruitment/homin

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Alnasser, Muhsen, Abdullah Hammad Alshammari, Amna Yusuf Siddiqui, et al. "Tissue Regeneration on Rise: Dental Hard Tissue Regeneration and Challenges—A Narrative Review." Scientifica 2024 (April 22, 2024): 1–13. http://dx.doi.org/10.1155/2024/9990562.

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Background. As people live longer, there is an increasing need for hard tissue regeneration and whole-tooth regeneration. Despite the advancements in the field of medicine, the field of regenerative dentistry is still challenging due to the complexity of dental hard tissues. Cross-disciplinary collaboration among material scientists, cellular biologists, and odontologists aimed at developing strategies and uncovering solutions related to dental tissue regeneration. Methodology. A search of the literature was done for pertinent research. Consistent with the Preferred Reporting Items for Systema

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Miran, Shayee, Thimios A. Mitsiadis, and Pierfrancesco Pagella. "Innovative Dental Stem Cell-Based Research Approaches: The Future of Dentistry." Stem Cells International 2016 (2016): 1–7. http://dx.doi.org/10.1155/2016/7231038.

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Over the past decade, the dental field has benefited from recent findings in stem cell biology and tissue engineering that led to the elaboration of novel ideas and concepts for the regeneration of dental tissues or entire new teeth. In particular, stem cell-based regenerative approaches are extremely promising since they aim at the full restoration of lost or damaged tissues, ensuring thus their functionality. These therapeutic approaches are already applied with success in clinics for the regeneration of other organs and consist of manipulation of stem cells and their administration to patie

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Wu, David T., Jose G. Munguia-Lopez, Ye Won Cho, et al. "Polymeric Scaffolds for Dental, Oral, and Craniofacial Regenerative Medicine." Molecules 26, no. 22 (2021): 7043. http://dx.doi.org/10.3390/molecules26227043.

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Dental, oral, and craniofacial (DOC) regenerative medicine aims to repair or regenerate DOC tissues including teeth, dental pulp, periodontal tissues, salivary gland, temporomandibular joint (TMJ), hard (bone, cartilage), and soft (muscle, nerve, skin) tissues of the craniofacial complex. Polymeric materials have a broad range of applications in biomedical engineering and regenerative medicine functioning as tissue engineering scaffolds, carriers for cell-based therapies, and biomedical devices for delivery of drugs and biologics. The focus of this review is to discuss the properties and clini

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Luo, Lihua, Yan He, Xiaoyan Wang, et al. "Potential Roles of Dental Pulp Stem Cells in Neural Regeneration and Repair." Stem Cells International 2018 (2018): 1–15. http://dx.doi.org/10.1155/2018/1731289.

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This review summarizes current advances in dental pulp stem cells (DPSCs) and their potential applications in the nervous diseases. Injured adult mammalian nervous system has a limited regenerative capacity due to an insufficient pool of precursor cells in both central and peripheral nervous systems. Nerve growth is also constrained by inhibitory factors (associated with central myelin) and barrier tissues (glial scarring). Stem cells, possessing the capacity of self-renewal and multicellular differentiation, promise new therapeutic strategies for overcoming these impediments to neural regener

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Xu, Ruoshi, Chenchen Zhou, Yuning Zhang, Shiwen Zhang, Jing Xie, and Quan Yuan. "Challenges of Stem-cell-based Craniofacial Regeneration." Current Stem Cell Research & Therapy 16, no. 6 (2021): 670–82. http://dx.doi.org/10.2174/1574888x16999210128193910.

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Oral diseases, such as dental caries, pulpitis, periodontitis, and craniofacial trauma, are common. Some individuals suffer from oral cancer or congenital craniofacial defects. The oral-systemic disease link reveals that a dental disorder is not a minor problem. Tissue loss is an inevitable consequence of most oral diseases, and repairing the tissue loss and restoring craniofacial function are highly expected by patients and are terminal targets of dental treatment. The current clinical approach for tissue loss due to dental caries, pulpitis, periodontitis, oral cancer, trauma, and development

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Sloan, Alastair J. "Whole-tooth tissue engineering: lessons from development." Faculty Dental Journal 2, no. 2 (2011): 84–86. http://dx.doi.org/10.1308/204268511x12988968522236.

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In an era of regenerative medicine, dentistry can be at the forefront due to the restorative procedures dental practitioners currently use. Orthopaedic practice encourages tissue regeneration through guided tissue regeneration and long term programmes of research on dental tissue regeneration have allowed us to develop a mechanistic understanding of the biological processes underpinning the key events during caries-induced natural tissue regeneration. These may be translated into novel therapies, which will improve on the relatively empirical traditional dental restorative approaches. Tissue e

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Sloan, Alastair J., and Christopher D. Lynch. "Dental Tissue Repair: Novel Models for Tissue Regeneration Strategies." Open Dentistry Journal 6, no. 1 (2012): 214–19. http://dx.doi.org/10.2174/1874210601206010214.

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Studies have shown that dentin matrices contain reservoirs of bioactive molecules capable of directing tissue repair. Elucidating the release mechanisms of such endogenous growth factors will enhance our understanding of dentinpulp regeneration and support the development of novel treatment modalities to enhance dentin repair following trauma and disease. Current clinical practice using new materials which are perceived to maintain pulpal viability require biological evidence to assess their therapeutic benefit and there is a need for better effective methods of assessing therapeutic approache

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Mantesso, Andrea, and Paul Sharpe. "Dental stem cells for tooth regeneration and repair." Expert Opinion on Biological Therapy 9, no. 9 (2009): 1143–54. http://dx.doi.org/10.1517/14712590903103795.

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Angjelova, Angela, Elena Jovanova, Alessandro Polizzi, et al. "Insights and Advancements in Periodontal Tissue Engineering and Bone Regeneration." Medicina 60, no. 5 (2024): 773. http://dx.doi.org/10.3390/medicina60050773.

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The regeneration of periodontal bone defects continues to be an essential therapeutic concern in dental biomaterials. Numerous biomaterials have been utilized in this sector so far. However, the immune response and vascularity in defect regions may be disregarded when evaluating the effectiveness of biomaterials for bone repair. Among several regenerative treatments, the most recent technique of in situ tissue engineering stands out for its ability to replicate endogenous restorative processes by combining scaffold with particular growth factors. Regenerative medicine solutions that combine bi

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Ibarretxe, Gaskon, Olatz Crende, Maitane Aurrekoetxea, Victoria García-Murga, Javier Etxaniz, and Fernando Unda. "Neural Crest Stem Cells from Dental Tissues: A New Hope for Dental and Neural Regeneration." Stem Cells International 2012 (2012): 1–12. http://dx.doi.org/10.1155/2012/103503.

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Several stem cell sources persist in the adult human body, which opens the doors to both allogeneic and autologous cell therapies. Tooth tissues have proven to be a surprisingly rich and accessible source of neural crest-derived ectomesenchymal stem cells (EMSCs), which may be employed to repair disease-affected oral tissues in advanced regenerative dentistry. Additionally, one area of medicine that demands intensive research on new sources of stem cells is nervous system regeneration, since this constitutes a therapeutic hope for patients affected by highly invalidating conditions such as spi

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Bi, Ruiye, Ping Lyu, Yiming Song, et al. "Function of Dental Follicle Progenitor/Stem Cells and Their Potential in Regenerative Medicine: From Mechanisms to Applications." Biomolecules 11, no. 7 (2021): 997. http://dx.doi.org/10.3390/biom11070997.

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Dental follicle progenitor/stem cells (DFPCs) are a group of dental mesenchyme stem cells that lie in the dental follicle and play a critical role in tooth development and maintaining function. Originating from neural crest, DFPCs harbor a multipotential differentiation capacity. More importantly, they have superiorities, including the easy accessibility and abundant sources, active self-renewal ability and noncontroversial sources compared with other stem cells, making them an attractive candidate in the field of tissue engineering. Recent advances highlight the excellent properties of DFPCs

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Malhotra, Neeraj. "Bioreactors Design, Types, Influencing Factors and Potential Application in Dentistry. A Literature Review." Current Stem Cell Research & Therapy 14, no. 4 (2019): 351–66. http://dx.doi.org/10.2174/1574888x14666190111105504.

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Objectives:A variety of bioreactors and related approaches have been applied to dental tissues as their use has become more essential in the field of regenerative dentistry and dental tissue engineering. The review discusses the various types of bioreactors and their potential application in dentistry.Methods:Review of the literature was conducted using keywords (and MeSH) like Bioreactor, Regenerative Dentistry, Fourth Factor, Stem Cells, etc., from the journals published in English. All the searched abstracts, published in indexed journals were read and reviewed to further refine the list of

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Goriuc, Ancuta, Liliana Foia, Karina Cojocaru, Diana Diaconu-Popa, Darius Sandu, and Ionut Luchian. "The Role and Involvement of Stem Cells in Periodontology." Biomedicines 11, no. 2 (2023): 387. http://dx.doi.org/10.3390/biomedicines11020387.

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Periodontitis is a widespread inflammatory condition, characterized by a progressive deterioration of the supporting structures of the teeth. Due to the complexity of periodontal tissue and the surrounding inflammatory microenvironment, the repair of lesions at this level represents a continuous challenge. The regeneration of periodontal tissues is considered a promising strategy. Stem cells have remarkable properties, such as immunomodulatory potential, proliferation, migration, and multilineage differentiation. Thus, they can be used to repair tissue damage and reduce inflammation, potential

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Terranova, V. P., M. Jendresen, and F. Young. "Healing, Regeneration, and Repair: Prospectus for New Dental Treatment." Advances in Dental Research 3, no. 1 (1989): 69–79. http://dx.doi.org/10.1177/08959374890030010601.

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Recent advances in our understanding of growth and development have led us to the realization that previously unattainable tissue regeneration and repair are now within the scope of patient care. Concurrent and complementary use of nonbiological substitutes, with complete biological integration and host acceptance, is becoming a leading recognized alternative to the loss of function of biological tissues. This manuscript will examine the implications of the new biotechnology in medical sciences for dental healing, regeneration, and repair. These concepts, when coupled with genetic engineering,

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Kim, Byunggyu, Ji-Young Yoon, Seong-Jin Shin, et al. "Clinical potential of deciduous teeth-derived dental pulp-derived stem cell therapy for tissue regeneration." Journal of The Korean Dental Association 62, no. 3 (2024): 150–63. http://dx.doi.org/10.22974/jkda.2024.62.3.001.

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Dental pulp stem cells are mesenchymal stem cells derived from the dental pulp tissue of permanent or deciduous teeth. Especially, stem cells from human exfoliated deciduous teeth (SHED) have an enhanced capacity than adult pulp stem cells counterpartfor self-renewal (proliferation) and multilineage differentiation, being able to generate dentin/pulp-like complexes, neural cells, skin cells, chondrocytes, and osteogenic cells, among others. Their accessibility from routine dental procedures and lack of ethical concerns make SHED an attractive stem cell source for regenerative therapy. This pap

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Miller, Lateefah, Muhammad M. Rahman, and Ramazan Asmatulu. "3D printed nanocomposite parts for improved dental recovery of decayed teeth." Journal of Management and Engineering Integration 14, no. 2 (2021): 34–42. http://dx.doi.org/10.62704/10057/24779.

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Bone regeneration and tooth recovery processes have been gaining much popularity and becoming a feasible process worldwide. This process is also called bone scaffolding and grafting where grafted bones are surgically placed to the section of the bone/tooth for repair. Recently, the 3D printing technology has been a great interest in research on bone and tissue repair with the use of 3D printed parts; however, research in dental repair has seen very little interest. In the U.S., adults have an average number of 3.28 decayed or missing permanent teeth and 13.65 decayed and missing permanent surf

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Almeida, Paula Nascimento, and Karin Soares Cunha. "Dental stem cells and their application in Dentistry: a literature review." Revistas 73, no. 4 (2016): 331. http://dx.doi.org/10.18363/rbo.v73n4.p.331.

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Objective: the aim of this study was to conduct a literature review of the types of stem cells of dental origin and their applications in Dentistry. Material and Methods: for this, we selected scientific articles published between 2000 and 2016 through the databases PUBMED and LILACS. Results: there are five main sources of stem cells of dental origin: stem cells from dental pulp of permanent teeth and deciduous teeth, apical papilla, periodontal ligament and dental follicle. These cells have been studied for the treatment of periodontitis, bone repair, regeneration of the pulp after necrosis

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Zhang, Weibo, and Pamela C. Yelick. "Tooth Repair and Regeneration: Potential of Dental Stem Cells." Trends in Molecular Medicine 27, no. 5 (2021): 501–11. http://dx.doi.org/10.1016/j.molmed.2021.02.005.

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Bai, Xiaolei, Ruijue Cao, Danni Wu, Huicong Zhang, Fan Yang, and Linhong Wang. "Dental Pulp Stem Cells for Bone Tissue Engineering: A Literature Review." Stem Cells International 2023 (October 11, 2023): 1–15. http://dx.doi.org/10.1155/2023/7357179.

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Bone tissue engineering (BTE) is a promising approach for repairing and regenerating damaged bone tissue, using stem cells and scaffold structures. Among various stem cell sources, dental pulp stem cells (DPSCs) have emerged as a potential candidate due to their multipotential capabilities, ability to undergo osteogenic differentiation, low immunogenicity, and ease of isolation. This article reviews the biological characteristics of DPSCs, their potential for BTE, and the underlying transcription factors and signaling pathways involved in osteogenic differentiation; it also highlights the appl

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Darmadi, Eveline Yulia, Yessy Andriani Fauziah, and Anneke Paramita Adityatama. "Role of the Immune System and Stem Cells in Dental Conservation." RSF Conference Series: Business, Management and Social Sciences 4, no. 1 (2024): 272–78. http://dx.doi.org/10.31098/bmss.v4i1.888.

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Background: Dental conservation aims to maintain teeth's appearance and functionality through various procedures. Recent advancements in stem cell research and immune system roles in tooth tissue regeneration highlight their crucial roles in oral health. The immune system is essential for healing after dental treatments and helps maintain oral health. A robust immune response can expedite the healing of damaged oral tissues and prevent further infections, enhancing the outcomes of dental conservation therapies. Purpose: This literature review examines immune system modulation and stem cell the

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Estrela, Carlos, Ana Helena Gonçalves de Alencar, Gregory Thomas Kitten, Eneida Franco Vencio, and Elisandra Gava. "Mesenchymal stem cells in the dental tissues: perspectives for tissue regeneration." Brazilian Dental Journal 22, no. 2 (2011): 91–98. http://dx.doi.org/10.1590/s0103-64402011000200001.

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In recent years, stem cell research has grown exponentially owing to the recognition that stem cell-based therapies have the potential to improve the life of patients with conditions that range from Alzheimer’s disease to cardiac ischemia and regenerative medicine, like bone or tooth loss. Based on their ability to rescue and/or repair injured tissue and partially restore organ function, multiple types of stem/progenitor cells have been speculated. Growing evidence demonstrates that stem cells are primarily found in niches and that certain tissues contain more stem cells than others. Among the

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Tawfik Tadros, Mary Sabry, Maha Abd-El Salam El-Baz, and Mohamed Adel Ezzat Khairy Khairy. "Dental stem cells in tooth repair: A systematic review." F1000Research 8 (November 22, 2019): 1955. http://dx.doi.org/10.12688/f1000research.21058.1.

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Background: Dental stem cells (DSCs) are self-renewable teeth cells, which help maintain or develop oral tissues. These cells can differentiate into odontoblasts, adipocytes, cementoblast-like cells, osteoblasts, or chondroblasts and form dentin/pulp. This systematic review aimed to summarize the current evidence regarding the role of these cells in dental pulp regeneration. Methods: We searched the following databases: PubMed, Cochrane Library, MEDLINE, SCOPUS, ScienceDirect, and Web of Science using relevant keywords. Case reports and non-English studies were excluded. We included all studie

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Singh, Manisha, Suchi Gupta, Sonali Rawat, et al. "Mechanisms of Action of Human Mesenchymal Stem Cells in Tissue Repair Regeneration and their Implications." Annals of the National Academy of Medical Sciences (India) 53, no. 02 (2017): 104–20. http://dx.doi.org/10.1055/s-0040-1712752.

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ABSTRACTCell replacement therapy holds a promising future in the treatment of degenerative diseases related to neuronal, cardiac and bone tissues. In such kind of diseases, there is a progressive loss of speciﬁc types of cells. Currently the most upcoming and trusted cell candidate is Mesenchymal Stem Cells (MSCs) as these cells are easy to isolate from the tissue, easy to maintain and expand and no ethical concerns are linked. MSCs can be obtained from a number of sources like bone marrow, umbilical cord blood, umbilical cord, dental pulp, adipose tissues, etc. MSCs help in tissue repair and

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Shanmugam, Kirubanandan. "Bio-Ceramics — An Introduction to Bone Repair Materials." Scientific and Social Research 6, no. 8 (2024): 9–30. http://dx.doi.org/10.26689/ssr.v6i8.6396.

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The realm of biomaterials, particularly ceramics, continues to revolutionize the fields of medicine and dentistry through their diverse applications and groundbreaking capabilities. From dental restorations to orthopedic implants and beyond, the biocompatibility, mechanical strength, and durability of ceramics have made them indispensable in the pursuit of enhancing patient care and outcomes. As research progresses, the potential of ceramics in supporting tissue regeneration, promoting bone healing, and creating more effective medical devices and implants is boundless. The ongoing development

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Shah, Dishant, Tyler Lynd, Donald Ho, et al. "Pulp–Dentin Tissue Healing Response: A Discussion of Current Biomedical Approaches." Journal of Clinical Medicine 9, no. 2 (2020): 434. http://dx.doi.org/10.3390/jcm9020434.

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Dental pulp tissue exposed to mechanical trauma or cariogenic process results in root canal and/or periapical infections, and conventionally treated with root canal procedures. The more recent regenerative endodontic procedure intends to achieve effective root canal disinfection and adequate pulp–dentin tissue regeneration; however, numerous limitations are reported. Because tooth is composed of vital soft pulp enclosed by the mineralized hard tissue in a highly organized structure, complete pulp–dentin tissue regeneration has been challenging to achieve. In consideration of the limitations an

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Amir, Mariam, Lakshmi Jeevithan, Maham Barkat та ін. "Advances in Regenerative Dentistry: A Systematic Review of Harnessing Wnt/β-Catenin in Dentin-Pulp Regeneration". Cells 13, № 13 (2024): 1153. http://dx.doi.org/10.3390/cells13131153.

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Dentin pulp has a complex function as a major unit in maintaining the vitality of teeth. In this sense, the Wnt/β-Catenin pathway has a vital part in tooth development, maintenance, repair, and regeneration by controlling physiological activities such as growth, differentiation, and migration. This pathway consists of a network of proteins, such as Wnt signaling molecules, which interact with receptors of targeted cells and play a role in development and adult tissue homeostasis. The Wnt signals are specific spatiotemporally, suggesting its intricate mechanism in development, regulation, repai

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Fujii, Yasuyuki, Ayano Hatori, Daichi Chikazu, and Toru Ogasawara. "Application of Dental Pulp Stem Cells for Bone and Neural Tissue Regeneration in Oral and Maxillofacial Region." Stem Cells International 2023 (March 29, 2023): 1–11. http://dx.doi.org/10.1155/2023/2026572.

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In the oral and maxillofacial region, the treatment of severe bone defects, caused by fractures, cancers, congenital abnormalities, etc., remains a great challenge. In addition, neurological disorders are frequently accompanied by these bone defects or the treatments for them. Therefore, novel bone regenerative techniques and methods to repair nerve injury are eagerly sought. Among them, strategies using dental pulp stem cells (DPSCs) are promising options. Human DPSCs can be collected easily from extracted teeth and are now considered a type of mesenchymal stem cell with higher clonogenic and

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Matichescu, Anamaria, Lavinia Cosmina Ardelean, Laura-Cristina Rusu, et al. "Advanced Biomaterials and Techniques for Oral Tissue Engineering and Regeneration—A Review." Materials 13, no. 22 (2020): 5303. http://dx.doi.org/10.3390/ma13225303.

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The reconstruction or repair of oral and maxillofacial functionalities and aesthetics is a priority for patients affected by tooth loss, congenital defects, trauma deformities, or various dental diseases. Therefore, in dental medicine, tissue reconstruction represents a major interest in oral and maxillofacial surgery, periodontics, orthodontics, endodontics, and even daily clinical practice. The current clinical approaches involve a vast array of techniques ranging from the traditional use of tissue grafts to the most innovative regenerative procedures, such as tissue engineering. In recent d

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Jimi, Eijiro, Shizu Hirata, Kenji Osawa, Masamichi Terashita, Chiaki Kitamura, and Hidefumi Fukushima. "The Current and Future Therapies of Bone Regeneration to Repair Bone Defects." International Journal of Dentistry 2012 (2012): 1–7. http://dx.doi.org/10.1155/2012/148261.

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Bone defects often result from tumor resection, congenital malformation, trauma, fractures, surgery, or periodontitis in dentistry. Although dental implants serve as an effective treatment to recover mouth function from tooth defects, many patients do not have the adequate bone volume to build an implant. The gold standard for the reconstruction of large bone defects is the use of autogenous bone grafts. While autogenous bone graft is the most effective clinical method, surgical stress to the part of the bone being extracted and the quantity of extractable bone limit this method. Recently mese

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Tatullo, Marco, Benedetta Marrelli, Francesca Palmieri, et al. "Promising Scaffold-Free Approaches in Translational Dentistry." International Journal of Environmental Research and Public Health 17, no. 9 (2020): 3001. http://dx.doi.org/10.3390/ijerph17093001.

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Regenerative medicine has recently improved the principal therapies in several medical fields. In the past ten years, the continuous search for novel approaches to treat the most common dental pathologies has developed a new branch called regenerative dentistry. The main research fields of translational dentistry involve biomimetic materials, orally derived stem cells, and tissue engineering to populate scaffolds with autologous stem cells and bioactive growth factors. The scientific literature has reported two main research trends in regenerative dentistry: scaffold-based and scaffold-free ap

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Savignat, M., L. De-Doncker, C. Vodouhe, J. M. Garza, P. Lavalle, and P. Libersa. "Rat Nerve Regeneration with the Use of a Polymeric Membrane Loaded with NGF." Journal of Dental Research 86, no. 11 (2007): 1051–56. http://dx.doi.org/10.1177/154405910708601106.

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Exogenous neurotrophic factors, delivered by various systems, are used to improve nerve regeneration. This study tested the effectiveness of a polymeric membrane loaded with Nerve Growth Factor (NGF) on mental nerve regeneration after a crush injury in rats. We tested NGF application, known to play a role in afferent fiber repair in dental neurobiology, to see if it could improve the regeneration. Afferent neurogram recordings and histological analyses of the trigeminal ganglion neurons were performed. One month after the crush injury, early regeneration was observed independently of exogenous

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Chalisserry, Elna Paul, Seung Yun Nam, Sang Hyug Park, and Sukumaran Anil. "Therapeutic potential of dental stem cells." Journal of Tissue Engineering 8 (January 1, 2017): 204173141770253. http://dx.doi.org/10.1177/2041731417702531.

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Stem cell biology has become an important field in regenerative medicine and tissue engineering therapy since the discovery and characterization of mesenchymal stem cells. Stem cell populations have also been isolated from human dental tissues, including dental pulp stem cells, stem cells from human exfoliated deciduous teeth, stem cells from apical papilla, dental follicle progenitor cells, and periodontal ligament stem cells. Dental stem cells are relatively easily obtainable and exhibit high plasticity and multipotential capabilities. The dental stem cells represent a gold standard for neur

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Liu, Haotian, Ke Xu, Yifan He, and Fang Huang. "Mitochondria in Multi-Directional Differentiation of Dental-Derived Mesenchymal Stem Cells." Biomolecules 14, no. 1 (2023): 12. http://dx.doi.org/10.3390/biom14010012.

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The pursuit of tissue regeneration has fueled decades of research in regenerative medicine. Among the numerous types of mesenchymal stem cells (MSCs), dental-derived mesenchymal stem cells (DMSCs) have recently emerged as a particularly promising candidate for tissue repair and regeneration. In recent years, evidence has highlighted the pivotal role of mitochondria in directing and orchestrating the differentiation processes of DMSCs. Beyond mitochondrial energy metabolism, the multifaceted functions of mitochondria are governed by the mitochondrial quality control (MQC) system, encompassing b

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Ohlsson, Ella, Kerstin M. Galler, and Matthias Widbiller. "A Compilation of Study Models for Dental Pulp Regeneration." International Journal of Molecular Sciences 23, no. 22 (2022): 14361. http://dx.doi.org/10.3390/ijms232214361.

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Efforts to heal damaged pulp tissue through tissue engineering have produced positive results in pilot trials. However, the differentiation between real regeneration and mere repair is not possible through clinical measures. Therefore, preclinical study models are still of great importance, both to gain insights into treatment outcomes on tissue and cell levels and to develop further concepts for dental pulp regeneration. This review aims at compiling information about different in vitro and in vivo ectopic, semiorthotopic, and orthotopic models. In this context, the differences between monola

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Cahaya, Cindy, and Sri Lelyati C. Masulili. "Perkembangan Terkini Membran Guided Tissue Regeneration/Guided Bone Regeneration sebagai Terapi Regenerasi Jaringan Periodontal." Majalah Kedokteran Gigi Indonesia 1, no. 1 (2015): 1. http://dx.doi.org/10.22146/majkedgiind.8810.

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Periodontitis adalah salah satu penyakit patologis yang mempengaruhi integritas sistem periodontal yang menyebabkan kerusakan jaringan periodontal yang berlanjut pada kehilangan gigi. Beberapa tahun belakangan ini banyak ketertarikan untuk melakukan usaha regenerasi jaringan periodontal, tidak saja untuk menghentikan proses perjalanan penyakit namun juga mengembalikan jaringan periodontal yang telah hilang. Sasaran dari terapi regeneratif periodontal adalah menggantikan tulang, sementum dan ligamentum periodontal pada permukaan gigi yang terkena penyakit. Prosedur regenerasi antara lain berupa

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Wei, Yali, Ping Lyu, Ruiye Bi, et al. "Neural Regeneration in Regenerative Endodontic Treatment: An Overview and Current Trends." International Journal of Molecular Sciences 23, no. 24 (2022): 15492. http://dx.doi.org/10.3390/ijms232415492.

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Pulpal and periapical diseases are the most common dental diseases. The traditional treatment is root canal therapy, which achieves satisfactory therapeutic outcomes—especially for mature permanent teeth. Apexification, pulpotomy, and pulp revascularization are common techniques used for immature permanent teeth to accelerate the development of the root. However, there are obstacles to achieving functional pulp regeneration. Recently, two methods have been proposed based on tissue engineering: stem cell transplantation, and cell homing. One of the goals of functional pulp regeneration is to ac

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Morsczeck, Christian, and Torsten E. Reichert. "Dental stem cells in tooth regeneration and repair in the future." Expert Opinion on Biological Therapy 18, no. 2 (2017): 187–96. http://dx.doi.org/10.1080/14712598.2018.1402004.

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Vishwanathaiah, Satish. "Regenerative Therapy in Dentistry: A Review." TEXILA INTERNATIONAL JOURNAL OF ACADEMIC RESEARCH 10, no. 2 (2023): 78–84. http://dx.doi.org/10.21522/tijar.2014.10.02.art008.

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Despite millions of people suffering from dental caries and periodontitis to date, we don’t have effective treatments that guarantee complete restoration of the impacted tissues. The current procedures mostly help in delaying the disease progress, and hence, bringing alternative approaches for whole tooth replacement has become indispensable. Considering the scenario, regenerative medicine seems to be the novel approach, given its innovative therapeutic techniques that aid in the repair and replacement of damaged, aged, diseased, or congenitally defective tissues and organs. While we are yet t

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Balic, Anamaria. "Biology Explaining Tooth Repair and Regeneration: A Mini-Review." Gerontology 64, no. 4 (2018): 382–88. http://dx.doi.org/10.1159/000486592.

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The tooth is an intricate composition of precisely patterned, mineralized matrices and soft tissues. Mineralized tissues include enamel (produced by the epithelial cells called ameloblasts), dentin and cementum (produced by mesenchymal cells called odontoblasts and cementoblasts, respectively), and soft tissues, which include the dental pulp and the periodontal ligament along with the invading nerves and blood vessels. It was perceived for a very long time that teeth primarily serve an esthetical function. In recent years, however, the role of healthy teeth, as well as the impact of oral healt

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Lin, Qingjie, Yong Zhang, and Yanguo Liu. "Data Mining-Based Clinical Study on the Effect of Oral Restoration Film in Guiding Oral Bone Regeneration and Dental Implantation." Journal of Healthcare Engineering 2021 (December 14, 2021): 1–8. http://dx.doi.org/10.1155/2021/3804271.

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Oral repair membrane guided oral bone regeneration, particularly in dental implants, is a guided regeneration technology for bone tissue. The principle is based on the characteristics of rapid migration of epithelial cells and fibroblasts and slower migration of osteoblasts. Materials are placed in the bone defect, creating a relatively closed environment which is conducive to the growth of bone tissue. In this paper, we have evaluated clinical effects of Hai’ao oral repair membrane as a barrier membrane to guide bone regeneration in implants. For this purpose, certain treatment data are colle

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Ducret, M., A. Costantini, S. Gobert, J.-C. Farges, and M. Bekhouche. "Fibrin-based scaffolds for dental pulp regeneration: from biology to nanotherapeutics." European Cells and Materials 41 (January 2, 2021): 1–14. http://dx.doi.org/10.22203/ecm.v041a01.

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Tissue engineering-based endodontic therapies, designed to regenerate the dental pulp (DP) in the devitalised endodontic space, have been proposed to improve tooth longevity compared to conventional root-filling therapies. Their aim is to restore tooth vitality and major DP functions necessary to maintain tooth health such as immunosurveillance, sensitivity and healing/repair/regenerative capacities. Several formulations based on the use of fibrin, the main component of the blood clot matrix, recently gave valuable results in the regeneration of the human DP. This review describes recent fibri

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Upadhyay, Akshaya, Sangeeth Pillai, Parisa Khayambashi, et al. "Biomimetic Aspects of Oral and Dentofacial Regeneration." Biomimetics 5, no. 4 (2020): 51. http://dx.doi.org/10.3390/biomimetics5040051.

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Biomimetic materials for hard and soft tissues have advanced in the fields of tissue engineering and regenerative medicine in dentistry. To examine these recent advances, we searched Medline (OVID) with the key terms “biomimetics”, “biomaterials”, and “biomimicry” combined with MeSH terms for “dentistry” and limited the date of publication between 2010–2020. Over 500 articles were obtained under clinical trials, randomized clinical trials, metanalysis, and systematic reviews developed in the past 10 years in three major areas of dentistry: restorative, orofacial surgery, and periodontics. Clin

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Brunello, Giulia, Federica Zanotti, Martina Trentini, et al. "Exosomes Derived from Dental Pulp Stem Cells Show Different Angiogenic and Osteogenic Properties in Relation to the Age of the Donor." Pharmaceutics 14, no. 5 (2022): 908. http://dx.doi.org/10.3390/pharmaceutics14050908.

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Craniofacial tissue reconstruction still represents a challenge in regenerative medicine. Mesenchymal stem cell (MSC)-based tissue engineering strategies have been introduced to enhance bone tissue repair. However, the risk of related complications is limiting their usage. To overcome these drawbacks, exosomes (EXOs) derived from MSCs have been recently proposed as a cell-free alternative to MSCs to direct tissue regeneration. It was hypothesized that there is a correlation between the biological properties of exosomes derived from the dental pulp and the age of the donor. The aim of the study

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Ibarretxe, Gaskon, Antonia Alvarez, Maria-Luz Cañavate, Enrique Hilario, Maitane Aurrekoetxea, and Fernando Unda. "Cell Reprogramming, IPS Limitations, and Overcoming Strategies in Dental Bioengineering." Stem Cells International 2012 (2012): 1–8. http://dx.doi.org/10.1155/2012/365932.

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The procurement of induced pluripotent stem cells, or IPS cells, from adult differentiated animal cells has the potential to revolutionize future medicine, where reprogrammed IPS cells may be used to repair disease-affected tissues on demand. The potential of IPS cell technology is tremendous, but it will be essential to improve the methodologies for IPS cell generation and to precisely evaluate each clone and subclone of IPS cells for their safety and efficacy. Additionally, the current state of knowledge on IPS cells advises that research on their regenerative properties is carried out in ap

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