Bibliografias temáticas / Cyclodextrins

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Literatura científica selecionada sobre o tema "Cyclodextrins"

Autor: Grafiati
Publicado: 4 de junho de 2021
Última modificação: 9 de novembro de 2024

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Artigos de revistas sobre o assunto "Cyclodextrins"

1

Labes, Antje, e Peter Schönheit. "Unusual Starch Degradation Pathway via Cyclodextrins in the Hyperthermophilic Sulfate-Reducing Archaeon Archaeoglobus fulgidus Strain 7324". Journal of Bacteriology 189, n.º 24 (5 de outubro de 2007): 8901–13. http://dx.doi.org/10.1128/jb.01136-07.

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ABSTRACT The hyperthermophilic archaeon Archaeoglobus fulgidus strain 7324 has been shown to grow on starch and sulfate and thus represents the first sulfate reducer able to degrade polymeric sugars. The enzymes involved in starch degradation to glucose 6-phosphate were studied. In extracts of starch-grown cells the activities of the classical starch degradation enzymes, α-amylase and amylopullulanase, could not be detected. Instead, evidence is presented here that A. fulgidus utilizes an unusual pathway of starch degradation involving cyclodextrins as intermediates. The pathway comprises the combined action of an extracellular cyclodextrin glucanotransferase (CGTase) converting starch to cyclodextrins and the intracellular conversion of cyclodextrins to glucose 6-phosphate via cyclodextrinase (CDase), maltodextrin phosphorylase (Mal-P), and phosphoglucomutase (PGM). These enzymes, which are all induced after growth on starch, were characterized. CGTase catalyzed the conversion of starch to mainly β-cyclodextrin. The gene encoding CGTase was cloned and sequenced and showed highest similarity to a glucanotransferase from Thermococcus litoralis. After transport of the cyclodextrins into the cell by a transport system to be defined, these molecules are linearized via a CDase, catalyzing exclusively the ring opening of the cyclodextrins to the respective maltooligodextrins. These are degraded by a Mal-P to glucose 1-phosphate. Finally, PGM catalyzes the conversion of glucose 1-phosphate to glucose 6-phosphate, which is further degraded to pyruvate via the modified Embden-Meyerhof pathway.
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Bansal, Paramjit S., Craig L. Francis, Noel K. Hart, Scott A. Henderson, David Oakenfull, Alan D. Robertson e Gregory W. Simpson. "Regioselective Alkylation of β-Cyclodextrin". Australian Journal of Chemistry 51, n.º 10 (1998): 915. http://dx.doi.org/10.1071/c98064.

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Methodology for preparation of heptakis(2,6-di-O-alkyl)-β-cyclodextrins, heptakis(2-O-alkyl)-β- cyclodextrins, and heptakis(6-O-alkyl)-β-cyclodextrins in substantially purified form has been developed. Treatment of β-cyclodextrin (1) with sodium or barium hydroxide and various alkyl halides in dimethyl sulfoxide or a mixture of dimethyl sulfoxide and N,N-dimethylformamide provided the corresponding heptakis(2,6-di-O-alkyl)-β-cyclodextrins. Treatment of heptakis(6-O-t-butyldimethylsilyl)-β-cyclodextrin (5) with sodium hydroxide and several haloalkanes in dimethyl sulfoxide followed by desilylation provided heptakis(2-O-alkyl)-β-cyclodextrins. Protection of the secondary hydroxy groups of the t-butyldimethylsilyl-β-cyclodextrin (5) as benzyl ethers, followed by desilylation, alkylation, and debenzylation afforded several heptakis(6-O-alkyl)-β-cyclodextrins. Analytical methodology has been developed to characterize all of these compounds, with the homogeneity of the pattern of substitution verified by h.p.l.c. analysis, f.a.b.–mass spectrometry and n.m.r. spectroscopy.
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Wang, Runmiao, Hui Zhou, Shirley W. I. Siu, Yong Gan, Yitao Wang e Defang Ouyang. "Comparison of Three Molecular Simulation Approaches for Cyclodextrin-Ibuprofen Complexation". Journal of Nanomaterials 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/193049.

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Cyclodextrins are widely used for the solubilisation of poorly soluble drugs in the formulations. However, current cyclodextrin formulation development strongly depends on trial-and-error in the laboratory, which is time-consuming and high cost. The aim of this research was to compare three modeling approaches (Docking, molecular dynamics (MD), and quantum mechanics (QM)) for cyclodextrin/drug complexation. Ibuprofen was used as a model drug. Binding free energy from three simulation methods was calculated as an important parameter to compare with the experimental results. Docking results from AutoDock Vina program showed that the scoring of complexation capability between ibuprofen and cyclodextrins is alpha (α), gamma (γ), beta (β), and HP-beta-cyclodextrins, which indicated similar ranking with the results from phase, solubility diagram experiments. MD simulation indicated that ibuprofen could form the stable complexes withβ-,γ-, and HP-β-cyclodextrins, but not for alpha cyclodextrin. Binding free energies from the MD simulation forβ-,γ-, and HP-β-cyclodextrins were −3.67, −0.67, and −3.87 kcal/mol, individually. The enthalpies of QM simulation forβ-,γ-, and HP-β-cyclodextrins were −17.22, −14.75, and −20.28 kcal/mol, respectively. Results from all three modeling approaches showed similar ranking between ibuprofen and four cyclodextrin molecules as the experimental data. However, MD simulation with entropy calculation had the closest value to experimental data forβand HP-beta-cyclodextrins. Thus, MD simulation with MM-PBSA method may be fit toin silicoscreen for cyclodextrin formulations.
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Lavandier, CD, MP Pelletier e VC Reinsborough. "Surfactant Inclusions by Modified β-Cyclodextrins". Australian Journal of Chemistry 44, n.º 3 (1991): 457. http://dx.doi.org/10.1071/ch9910457.

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Binding constants for the inclusion of sodium alkane-1-sulfonates (C5-C10, C12) by four modified β- cyclodextrins (2,6-O-dimethyl-β-cyclodextrin, 2,3,6-O-trimethyl-β-cyclodextrin, hydroxypropyl-β-cyclodextrin and maltosyl-β-cyclodextrin ) were determined conductimetrically at 25°C. Binding increased with increasing length of the alkyl chain. Generally, the substituted β- cyclodextrins were no more effective as encapsulating agents than ordinary β- cyclodextrin with the persubstituted 2,3,6-O-trimethyl-β-cyclodextrin being the weakest.
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Easton, Christopher J., Steven J. van Eyk, Stephen F. Lincoln, Bruce L. May, John Papageorgiou e Michael L. Williams. "A Versatile Synthesis of Linked Cyclodextrins". Australian Journal of Chemistry 50, n.º 1 (1997): 9. http://dx.doi.org/10.1071/c96168.

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Reactions of amino-substituted cyclodextrins with bis(3-nitrophenyl) oxalate, malonate, succinate and glutarate, and with diphenyl carbonate, afford a range of linked cyclodextrins. These include α- and β-cyclodextrin dimers, joined by substitution at either C6 or C3, and asymmetric species with a β-cyclodextrin bonded to an a-cyclodextrin and a C3-substituted cyclodextrin attached to a C6-substituted moiety.
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Castillo Cruz, Betzaida, Sandra Chinapen Barletta, Bryan G. Ortiz Muñoz, Adriana S. Benitez-Reyes, Omar A. Amalbert Perez, Alexander C. Cardona Amador, Pablo E. Vivas-Mejia e Gabriel L. Barletta. "Effect of Cyclodextrins Formulated in Liposomes and Gold and Selenium Nanoparticles on siRNA Stability in Cell Culture Medium". Pharmaceuticals 17, n.º 10 (8 de outubro de 2024): 1344. http://dx.doi.org/10.3390/ph17101344.

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Background: Encapsulation of siRNA fragments inside liposome vesicles has emerged as an effective method for delivering siRNAs in vitro and in vivo. However, the liposome’s fluid-phospholipid bilayer of liposomes allows siRNA fragments to diffuse out of the liposome, decreasing the dose concentration and therefore the effectiveness of the carrier. We have previously reported that β-cyclodextrins formulated in liposomes help increase the stability of siRNAs in cell culture medium. Here, we continued that study to include α, γ, methyl-β-cyclodextrins and β-cyclodextrin-modified gold and selenium nanoparticles. Methods: We used Isothermal Titration Calorimetry to study the binding thermodynamics of siRNAs to the cyclodextrin-modified nanoparticles and to screen for the best adamantane derivative to modify the siRNA fragments, and we used gel electrophoresis to study the stabilization effect of siRNA by cyclodextrins and the nanoparticles. Results: We found that only β- and methyl-β-cyclodextrins increased siRNA serum stability. Cyclodextrin-modified selenium nanoparticles also stabilize siRNA fragments in serum, and siRNAs chemically modified with an adamantane moiety (which forms inclusion complexes with the cyclodextrin-modified-nanoparticles) show a strong stabilization effect. Conclusions: β-cyclodextrins are good additives to stabilize siRNA in cell culture medium, and the thermodynamic data we generated of the interaction between cyclodextrins and adamantane analogs (widely used in drug delivery studies), should serve as a guide for future studies where cyclodextrins are sought for the delivery and solvation of small organic molecules.
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Fenyvesi, Ferenc. "Biological Studies on Cyclodextrins". Proceedings 78, n.º 1 (1 de dezembro de 2020): 60. http://dx.doi.org/10.3390/iecp2020-08692.

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In recent years, our knowledge of the biological effects of cyclodextrins has grown significantly. Cellular actions of cyclodextrins originate in their ability to form complexes with lipophilic biomolecules. Cyclodextrins can target different types of molecules according to their size, for instance, alpha-cyclodextrins form complexes with phospholipids, while beta-cyclodextrins can bind cholesterol or prostaglandin E2. Due to their interactions with the main membrane constituents, cyclodextrins can affect the barrier function of biological barriers or influence the function of membrane proteins. Nevertheless, cyclodextrins can enter the cells by endocytosis and affect the intracellular cholesterol storage. Based on these findings, 2-hydroxypropyl-beta cyclodextrin (HPBCD) received the orphan designation for the treatment of Niemann–Pick disease type C. The endocytosis of cyclodextrins works in different cell types and can be applied in the delivery of drugs into the cells. The tissue distribution and pharmacokinetics of cyclodextrins could be further characterized by imaging techniques. Radiolabeled HPBCD and randomly methylated beta-cyclodextrin (RAMEB) were recently used to study their in vivo behavior by positron emission tomography. Interestingly, RAMEB accumulation was detected in prostaglandin E2 (PGE2)-positive tumors. These findings can promote further research and the application of cyclodextrins in inflammation and tumor diagnosis or targeting. The presentation aims to give an overview of the main biological effects of cyclodextrins and the recent results of this research field.
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Yhaya, Firdaus, Andrew M. Gregory e Martina H. Stenzel. "Polymers with Sugar Buckets - The Attachment of Cyclodextrins onto Polymer Chains". Australian Journal of Chemistry 63, n.º 2 (2010): 195. http://dx.doi.org/10.1071/ch09516.

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This Review summarizes the structures obtained when marrying synthetic polymers of varying architectures with cyclodextrins. Polymers with cyclodextrin pendant groups were obtained by directly polymerizing cyclodextrin-based monomers or by postmodification of reactive polymers with cyclodextrins. Star polymers with cyclodextrin as the core with up to 21 arms were usually obtained by using modified cyclodextrins as initiator or controlling agent. Limited reports are available on the synthesis of star polymers by arm-first techniques, which all employed azide-functionalized cyclodextrin and ‘click’ chemistry to attach seven polymer arms to the cyclodextrin core. Polymer chains with one or two cyclodextrin terminal units were reported as well as star polymers carrying a cyclodextrin molecule at the end of each arm. Cyclodextrin polymers were obtained using different polymerization techniques ranging from atom transfer radical polymerization, reversible addition–fragmentation chain transfer polymerization, nitroxide-mediated polymerization, free radical polymerization to (ionic) ring-opening polymerization, and polycondensation. Cyclodextrin polymers touch all areas of polymer science from gene delivery, self-assembled structures, drug carriers, molecular sensors, hydrogels, and liquid crystalline polymers. This Review attempts to focus on the range of work conducted with polymers and cyclodextrins and highlights some of the key areas where these macromolecules have been applied.
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S. Panwar, Vikas, Lokesh Adhikari, Mona Semalty e Ajay Semalty. "DRUG-CYCLODEXTRIN COMPLEXES: CURRENT STATUS AND RECENT ADVANCEMENTS". INDIAN DRUGS 60, n.º 10 (28 de outubro de 2023): 7–18. http://dx.doi.org/10.53879/id.60.10.12952.

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Cyclodextrins are water-soluble oligosaccharides formed by the action of cyclodextrin glucosyl transferase enzyme (CGTase) on the medium containing starch. Cyclodextrins are proven to be a cost-effective breakthrough in the pharmaceutical industry by formulating them with polymers and drugs to improve the safety, bioavailability, and solubility of APIs. This review describes the current status and advancement of cyclodextrin research in drug delivery. The use of cyclodextrins to improve the solubility and dissolution properties of poor water-soluble products has been reviewed exhaustively with a specific focus on their physicochemical property, practical methods, toxicity, the drug-cyclodextrin compatibility and its applications.
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Sivakumar, Ponnurengam M., Shohreh Peimanfard, Ali Zarrabi, Arezoo Khosravi e Matin Islami. "Cyclodextrin-Based Nanosystems as Drug Carriers for Cancer Therapy". Anti-Cancer Agents in Medicinal Chemistry 20, n.º 11 (8 de julho de 2020): 1327–39. http://dx.doi.org/10.2174/1871520619666190906160359.

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Background and Objective: Cyclodextrins have been of great interest as excellent candidates for fabricating versatile nano-drug delivery systems due to their commercial availability, easy functionalization, low immunogenicity, biocompatibility and safety. The possibility of reversible inclusion complex formation between cyclodextrins and various guest molecules in association with versatile exclusive properties of cyclodextrins offer a route towards the fabrication of highly sophisticated nanostructures with enormous potential for cancer treatment. Methods and Results: The current review discusses important recent advances in the fabrication and development of cyclodextrin-based nanostructures for cancer therapy. Firstly, the formation of inclusion complexes between cyclodextrin derivatives and anticancer compounds, as well as their application, are summarized. Secondly, the cyclodextrins -based nanosystems including cyclodextrin-containing polymers, cyclodextrin-based supramolecular necklaces, which consist of polyrotaxanes and polypseudorotaxanes and cyclodextrin based hydrogels accompanied by their applications in cancer treatment are highlighted. In the end, the future perspective of this field is discussed. Conclusion: Numerous investigations in this area pave the way for the flourishing of the next generation of nano-therapeutics towards enhanced cancer therapy.
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Teses / dissertações sobre o assunto "Cyclodextrins"

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Nemeth, Richard Desider. "Linked Beta-Cyclodextrins". W&M ScholarWorks, 1988. https://scholarworks.wm.edu/etd/1539625449.

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Liu, Enxu. "Design of molecular Brownian ratchets exploiting the asymmetry of functionalized cyclodextrins". Electronic Thesis or Diss., Sorbonne université, 2023. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2023SORUS654.pdf.

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Au cours des dernières années, les avancées dans le domaine des machines moléculaires ont été remarquables. Néanmoins, la réalisation d'un mouvement unidirectionnel contrôlé au sein de ces nanostructures reste compliquée. L'objet de cette thèse est d'exploiter l'asymétrie intrinsèque de la cyclodextrine (CD) pour développer des machines moléculaires capables de réaliser un mouvement unidirectionnel. Une série de [2]rotaxanes, comportant une α-CD perméthylée simple ou fonctionnalisée avec une amine sur le col primaire a été synthétisée.Dans une première partie, un mécanisme de cliquet d'information a été mis au point sur un [2]rotaxane de CD perméthylée. Il a été observé que la cinétique de protection de l'axe par des groupements Fmoc dépend de l'orientation et de la position de la CD. Ces données suggèrent que la forme conique asymétrique du macrocycle instaure un mécanisme original de type cliquet d'information, ouvrant des perspectives pour la conception de moteurs moléculaires de nouvelle génération.Dans une seconde partie, l'introduction d'une fonction diméthylamine sur le col primaire de la CD du [2]rotaxane a été réalisée. Cette modification vise à catalyser la déprotection intramoléculaire du groupement Fmoc devant le col primaire de la CD. Ce hypothèse a été optimisé sur un système de [2]rotaxane modèle. Un mouvement unidirectionnel à travers un processus cyclique de protection et de déprotection du Fmoc semble accessible. Ces résultats démontrent l'intérêt de la construction des moteurs moléculaires avec des CD fonctionnalisées
Over recent years, molecular machines have been widely developed, yet mastering unidirectional movement in these nano-entities remains challenging. This thesis focuses on harnessing the inherent asymmetry of cyclodextrin (CD) to design molecular machines that are able to perform unidirectional motion. A range of [2]rotaxanes, incorporating methylated α-CD, either amine-functionalized at the primary rim or permethylated was synthesized.In the first part, an information ratchet system was discovered on a permethylated α-CD [2]rotaxane. The kinetics of the Fmoc protection of the axle are influenced by the CD's orientation and position. These findings suggest that the asymmetric conical shape of the macrocycle establishes a unique information ratchet mechanism, paving the way for the design of next-generation molecular motors.In the second part, the introduction of a dimethylamine function on the primary rim of the CD of the [2]rotaxane was carried out. This modification aims to catalyze the intramolecular deprotection of the Fmoc group faces to the primary rim of the CD. This hypothesis was optimized on a model [2]rotaxane system. A unidirectional movement through a cyclic process of protection and deprotection of the Fmoc appears feasible. These results highlight the potential of building molecular motors with functionalized CDs
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Brown, Susan Elizabeth. "Molecular recognition by cyclodextrins /". Title page, contents and abstract only, 1994. http://web4.library.adelaide.edu.au/theses/09PH/09phb8798.pdf.

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Yan, Jinglan. "Sulfated ß-cyclodextrins in enantiomeric separations and mobility conservation model in cyclodextrin-mediated capillary electrophoresis". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ35009.pdf.

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Haskard, Carolyn Anne. "Multiple recognition by modified cyclodextrins". Title page, contents and abstract only, 1996. http://web4.library.adelaide.edu.au/theses/09PH/09phh349.pdf.

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Copy of author's previously published article inserted. Includes bibliographies This thesis studies the B-cyclodextrins which are modified at the primary rim to incorporate an additional coordination or hydrophobic recognition site. The natural organic host, cyclodextrin and its chemically modified derivatives, are utilised as hosts for the inclusion of a range of guests. The study contributes to understanding the fundamental factors influencing selectivity of binding and the stability of the complexes formed when a guest is bound essentially at two recognition sites.
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Kean, Suzanna Dawn. "Modified cyclodextrins and their complexes". Title page, contents and abstract only, 1999. http://web4.library.adelaide.edu.au/theses/09PH/09phk243.pdf.

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Addendum page pasted onto front end paper. Copies of author's previously published articles inserted. Includes bibliographical references. Investigates the factors that govern the stability of cyclodextrin inclusion complexes with a range of systematically modified cyclodextrins.
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Palmer, Simon Richard Faunch. "Electroanalytical sensors using lipophilic cyclodextrins". Thesis, Durham University, 1997. http://etheses.dur.ac.uk/4753/.

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Lipophilic dialkylated-a-, β- and γ-cyclodextrin derivatives were used as selective ionophores for a series of clinically relevant ammonium ions, and as enantioselective ionophores for both a- and β-aryl ammonium ions. Sensitive and selective potentiometric detection of the local anaesthetics lidocaine and bupivacaine was achieved by using 2,3,6 trioctyl-β-cyclodextrin as the ionophore, leading to micromolar detection limits. Interference studies showed that the simulated clinical electrolyte background caused minimal interference whereas organic interferents of similar size and charge caused some perturbation of the electrode response at a concentration of 10 mmol dm(^-3). An electrode comprising a plasticized biocompatible membrane matrix, TECOFLEX, with 2,6 didodecyl-β-cyclodextrin was incorporated in a flow injection analysis system and the response to lidocaine studied in the presence of human serum. Human serum caused no adverse effects to the electrochemical response of the electrode. These electrodes are, therefore, very suitable for on-line detection of local anaesthetics. Potentiometric detection of tricyclic antidepressants using didodecyl-a-, β- and γ- cyclodextrins as the ionophore, gave micromolar detection limits. Interference from simulated clinical electiolyte background and selected organic interferents gave similar results to those discussed above. In order to lower the detection limit to sub-nanomolar levels modified amperometric electrodes were assembled by depositing a membrane comprising plasticised TECOFLEX, 2,3,6 triethyl-β-cyclodextrin and TKB on the working electrode of a screen printed electrode. Lipophilic 2,6 didodecyl-a- and β-cyclodextrins exhibited enantiomeric discrimination in the binding of propranolol, ephedrine, amphetamine and methamphetamine. These results were confirmed using potentiometric and NMR techniques.
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Jones, S. P. "Interaction of drugs with cyclodextrins". Thesis, University of Nottingham, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.355923.

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De, Vries Elise Janine Christl. "Inclusion of alkylparabens in cyclodextrins". Doctoral thesis, University of Cape Town, 2003. http://hdl.handle.net/11427/6302.

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Includes bibliographical references.
The aim of this thesis was to prepare crystalline inclusion complexes with cyclodextrins (CDs), as hosts, and drugs, as guests, characterise them using various methods and attempt to elucidate their structures by X-ray diffraction methods to establish the detailed mode of drug inclusion in the solid state. Cyclodextrins and their derivatives have a low polarity central void formed by linked glucose residues of varying numbers. This annular cavity is able to encapsualte low molecular weight molecules and is therefore responsible for the great interest in CDs in host-guest chemistry. In addition, inclusion of drug molecules in cyclodextrins can significantly improve aspects of their performance, such as increased aqueous solubility and dissolution rates which lead to their increasing application in the pharmaceutical industry.
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Al-Derbali, Meftah Abdulhafied. "Formulation and evaluation of zidovudine cyclodextrin inclusion complex to enhance acid lability and palatability". University of the Western Cape, 2016. http://hdl.handle.net/11394/5052.

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Magister Pharmaceuticae - MPharm
Background: Zidovudine (AZT) is a very useful drug for the management of Human Immunodeficiency Virus (HIV) infection. Its optimal use is limited by its bitter taste, sparing solubility (20.1 mg/ml) and acid lability. Cyclodextrins (CD) are a class of compounds which can be used to form inclusion complexes with drugs such as AZT to improve it is taste, solubility and palatability. Purpose: This study complexed hydroxypropyl-beta-cyclodextrin (HPβCD) with AZT. The formulated inclusion complex was evaluated for suitability as a dosage form and as a tool for improving AZT’s palatability, solubility and acid liability. Method: AZT was complexed with HPβCD using the lyophilisation method. The binding constant for the formulation was determined by the phase solubility method, and complex formation between AZT and HPβCD evaluated using proton nuclear magnetic resonance (1H NMR), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and hot stage microscopy (HSM). Tablets of the inclusion complex were formulated by direct compression, using the least possible amount of excipients, and the dosage form evaluated for hardness, friability, durability, disintegration time and dissolution. Results: The binding constant of the formulation was 3.919, and the degree of incorporation was 4.0 mg AZT/g of CD per complex. 1H NMR showed significant chemical shifts between the inclusion complex and AZT. DSC and TGA analyses showed significant differences in the curves for the pure AZT and HPβCD. Values for tablet hardness, friability, durability and disintegration time were 236 ± 20 N, 0.7 %, 1.02 % and 10.25 minutes, respectively. The solubility of the formulation was 148.08 mg/ml, and its dissolution profile was different from that of the branded formulation. Conclusions: AZT-HPβCD inclusion complex, with a 7.4-fold increase in AZT solubility, was successfully prepared using the lyophilisation method. The binding constant and friability of the formulation were within acceptable limits. Although the hardness value is high, the tablet still disintegrated within acceptable specified times. This study has significant implications for anti-retroviral complex formulations.
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Livros sobre o assunto "Cyclodextrins"

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Amiri, Sahar, e Sanam Amiri. Cyclodextrins. Chichester, UK: John Wiley & Sons, Ltd, 2017. http://dx.doi.org/10.1002/9781119247609.

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Sliwa, Wanda, e Tomasz Girek, eds. Cyclodextrins. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2017. http://dx.doi.org/10.1002/9783527695294.

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3

Armspach, Dominique. Catenated cyclodextrins. Birmingham: University of Birmingham, 1994.

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4

Bang, Kim Quynh. CU(II) complexes with cyclodextrins and with amino-cyclodextrin. Dublin: University College Dublin, 1997.

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5

Frömming, Karl-Heinz, e József Szejtli. Cyclodextrins in Pharmacy. Dordrecht: Springer Netherlands, 1994. http://dx.doi.org/10.1007/978-94-015-8277-3.

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Frömming, Karl-Heinz. Cyclodextrins in pharmacy. Dordrecht: Kluwer Academic Publishers, 1994.

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7

1957-, Forgács Esther, e Royal Society of Chemistry (Great Britain), eds. Cyclodextrins in chromatography. Cambridge: Royal Society of Chemistry, 2003.

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8

Crini, Grégorio, Sophie Fourmentin e Eric Lichtfouse, eds. The History of Cyclodextrins. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-49308-0.

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Mäkelä, Mauri J. Biotechnological production of cyclodextrins. Turku: M. Mäkelä, 1990.

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10

Brady, Mary Bernadette. Host-guest chemistry of Thioglycosidic Cyclodextrins. Dublin: University College Dublin, 1995.

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Capítulos de livros sobre o assunto "Cyclodextrins"

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Breslow, Ronald. "Cyclodextrins". In Molecular Encapsulation, 43–69. Chichester, UK: John Wiley & Sons, Ltd, 2010. http://dx.doi.org/10.1002/9780470664872.ch2.

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Robyt, John F. "Cyclodextrins". In Springer Advanced Texts in Chemistry, 245–61. New York, NY: Springer New York, 1998. http://dx.doi.org/10.1007/978-1-4612-1622-3_8.

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Trotta, Francesco. "Cyclodextrins". In Encyclopedia of Membranes, 507–8. Berlin, Heidelberg: Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-44324-8_2045.

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Frömming, Karl-Heinz, e József Szejtli. "Cyclodextrins". In Topics in Inclusion Science, 1–18. Dordrecht: Springer Netherlands, 1994. http://dx.doi.org/10.1007/978-94-015-8277-3_1.

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Szejtli, József. "Cyclodextrins". In Topics in Inclusion Science, 1–78. Dordrecht: Springer Netherlands, 1988. http://dx.doi.org/10.1007/978-94-015-7797-7_1.

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Sá Couto, André, Paulo Salústio e Helena Cabral-Marques. "Cyclodextrins". In Polysaccharides, 247–88. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-16298-0_22.

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Trotta, Francesco. "Cyclodextrins". In Encyclopedia of Membranes, 1–3. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-40872-4_2045-1.

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Salmaso, Stefano, e Fabio Sonvico. "Targeted Cyclodextrins". In Cyclodextrins in Pharmaceutics, Cosmetics, and Biomedicine, 251–73. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2011. http://dx.doi.org/10.1002/9780470926819.ch13.

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Russell, N. R., e M. McNamara. "Metallo — Cyclodextrins". In Proceedings of the Eighth International Symposium on Cyclodextrins, 163–69. Dordrecht: Springer Netherlands, 1996. http://dx.doi.org/10.1007/978-94-011-5448-2_34.

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Szejtli, József. "Ubiquitous Cyclodextrins". In Culture of Chemistry, 261–69. Boston, MA: Springer US, 2015. http://dx.doi.org/10.1007/978-1-4899-7565-2_50.

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Trabalhos de conferências sobre o assunto "Cyclodextrins"

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DRANNIKOV, A. A., A. DI MARTINO e M. E. TRUSOVA. "RHEOLOGICAL STUDY OF MUCOADHESION OF GRAMICIDIN S: HYDROXYPROPYL-ß- CYCLODEXTRIN INCLUSION COMPLEX AND HOW IT IS AFFECTED BY CHITOSAN". In ФАРМОБРАЗОВАНИЕ-2023 Воронеж. Воронежский государственный университет, 2023. http://dx.doi.org/10.17308/978-5-9273-3827-6-2023-217-221.

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Cyclodextrins became famous for their ability to encapsulate chemical compounds, further modifying their properties. In present research, we focused on the mucoadhesion studies of gramicidin S and how it can be influenced by complex formation with hydroxypropyl-ß-cyclodextrin and chitosan. For the investigation, we applied the rheological method using the rotation viscometer. In accordance with the structural properties, hydroxypropyl-ß-cyclodextrin reduces the mucoadhesion of the peptide while chitosan increases. At the same time, both of these compositions can be considered as a possible way to reduce the influence of gramicidin S on the oral mucosa. Complex formation with hydroxypropyl-ß-cyclodextrin leads to lower mucoadhesion of the peptide to the health tissue surface, while interaction with chitosan allows the localization of antibiotic on the infected area, which can enhance the antibacterial effect.
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Nozawa, Ryo, Mohammad Ferdows, Kazuhiko Murakami e Masahiro Ota. "Effects of Cyclodextrin Solutions on Methane Hydrate Formation". In ASME/JSME 2007 Thermal Engineering Heat Transfer Summer Conference collocated with the ASME 2007 InterPACK Conference. ASMEDC, 2007. http://dx.doi.org/10.1115/ht2007-32987.

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In this paper, we suggest the advanced method of methane hydrate formation by cyclodextrin solutions. The structures of the methane hydrate were experimentally investigated by Raman spectroscopy. The induction time of the methane hydrate formation becomes by shorter 10–30 times and formation rate become by faster 2–4 times originated in the increased methane concentration of hydrate formation water by adding cyclodextrins. The results by the Raman spectroscopy indicate that the structure I methane hydrate is produced and methane molecules exist in both Large and Small cages.
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Jicsinszky, Laszlo, e Robert Ivanyi. "SELECTIVE SUBSTITUTION OF CYCLODEXTRINS: PREPARATION OF NITROGEN CONTAINING CYCLODEXTRINS". In XXIst International Carbohydrate Symposium 2002. TheScientificWorld Ltd, 2002. http://dx.doi.org/10.1100/tsw.2002.392.

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Zavodnik, I. B., E. A. Lapshina, T. V. Ilyich, A. G. Veiko, T. A. Kovalenia e V. U. Buko. "REGULATORY, ANTIOXIDATIVE AND HEPATOPROTECTIVE EFFECTS OF PLANT POLYPHENOLS AND THEIR NANOSTRUCTURED COMPLEXES". In SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY. International Sakharov Environmental Institute, 2021. http://dx.doi.org/10.46646/sakh-2021-1-255-258.

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Flavonoids, secondary plant metabolites, demonstrate a wide range of biological and pharmacological activities. In our experiment, flavonoids and their complexes with cyclodextrins (10—100 gM) dose-dependently prevented lipid peroxidation of erythrocyte and mitochondrial membranes, inhibited oxidation of reduced glutathione, and modulated the proapoptotic process of the mitochondrial permeability transition pores formation, that depends on flavonoid lipophilicity and structures. Generation of maps of the electron density distribution in the quercetin molecule and the quercetin semiquinone radical shows that the active electronic orbitals of quercetin and its semiquinone radical are delocalized along the phenolic rings, which, in the case of a radical, increases radical stability. The quercetin-hydroxypropyl-e-cyclodextrin complex proved to be a more effective antioxidant.
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Bednarz, Szczepan, Marcin Lukasiewicz, Wojciech Mazela, Michal Pajda, Stanislaw Kowalski, Sabina Foks, Anna Garlicka, Maciej Kabzinski e Kacper Kaczmarczyk. "Processes of Cyclodextrins grafting on cotton". In The 11th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2007. http://dx.doi.org/10.3390/ecsoc-11-01355.

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Papezhuk, M. V., A. V. Chemodanova, V. A. Volynkin e V. T. Panyushkin. "FUNCTIONALIZED CYCLODEXTRINS FOR TARGETED DRUG TRANSPORT". In MedChem-Russia 2021. 5-я Российская конференция по медицинской химии с международным участием «МедХим-Россия 2021». Издательство Волгоградского государственного медицинского университета, 2021. http://dx.doi.org/10.19163/medchemrussia2021-2021-502.

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Ambrus, Rita, Csilla Bartos, Gábor Katona, Tamás Kiss, Zoltán Aigner e Piroska Szabó-Révész. "Cyclodextrins in traditional and alternative drug formulations". In The 1st International Electronic Conference on Pharmaceutics. Basel, Switzerland: MDPI, 2020. http://dx.doi.org/10.3390/iecp2020-08912.

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Alvarez-Lorenzo, Carmen. "Cyclodextrins as multipurpose materials for bone regeneration". In The 1st International Electronic Conference on Pharmaceutics. Basel, Switzerland: MDPI, 2020. http://dx.doi.org/10.3390/iecp2020-08688.

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Ueno, Akihiko, Hiroshi Ikeda e Taiyo Aoyagi. "Signal transduction in chemosensors of modified cyclodextrins". In BiOS '97, Part of Photonics West, editado por Richard B. Thompson. SPIE, 1997. http://dx.doi.org/10.1117/12.273523.

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Wirén, Charlotta, Mònica Campàs, Maria Rambla-Alegre, Anna Safont, Carles Alcaraz, Jorge Diogène, Mabel Torréns e Alex Fragoso. "Cyclodextrins as capture agents of lipophilic marine toxins". In 1st International Electronic Conference on Toxins. Basel, Switzerland: MDPI, 2021. http://dx.doi.org/10.3390/iect2021-09170.

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Relatórios de organizações sobre o assunto "Cyclodextrins"

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Hunt, J., A. Wagner e T. Michalski. Application of sup 252 CF-PDMS in the analysis of cyclodextrins and their derivatives. Office of Scientific and Technical Information (OSTI), janeiro de 1990. http://dx.doi.org/10.2172/6985784.

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Young, Sandra K., Peter L. Vajda, Eugene Napadensky, Dawn M. Crawford e James M. Sloan. Structure-Scavenging Abilities of Cyclodextrin-Based Polyurethanes. Fort Belvoir, VA: Defense Technical Information Center, julho de 2002. http://dx.doi.org/10.21236/ada406085.

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Li, DeQuan. Cyclodextrin-based chemical microsensors for Volatile Organic Compounds (VOCs). Office of Scientific and Technical Information (OSTI), dezembro de 1998. http://dx.doi.org/10.2172/562505.

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Lee, Chaijun, Jihyun Lee, Jinwoong Jung e Ildoo Chung. Synthesis and characterization of polyrotaxane based on mono-6-tosyl-β -cyclodextrin. Peeref, julho de 2023. http://dx.doi.org/10.54985/peeref.2307p1226234.

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RHODE ISLAND UNIV KINGSTON. Cyclodextrin-Enhanced In Situ Removal of Organic Contaminants from Groundwater at Department of Defense Sites. Fort Belvoir, VA: Defense Technical Information Center, maio de 2004. http://dx.doi.org/10.21236/ada607331.

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Dr. Thieo Hogen-Esch. Complex formation of beta-cyclodextrin in aqueous media with poly(N,N-dimethylacrylamide)containing pendent perfluorooctanesulfonamido groups. Final Report, September 15, 1998 - September 14, 1999. Office of Scientific and Technical Information (OSTI), novembro de 1999. http://dx.doi.org/10.2172/756725.

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Choudhary, Ruplal, Victor Rodov, Punit Kohli, Elena Poverenov, John Haddock e Moshe Shemesh. Antimicrobial functionalized nanoparticles for enhancing food safety and quality. United States Department of Agriculture, janeiro de 2013. http://dx.doi.org/10.32747/2013.7598156.bard.

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Original objectives The general goal of the project was to utilize the bactericidal potential of curcumin- functionalizednanostructures (CFN) for reinforcement of food safety by developing active antimicrobial food-contact surfaces. In order to reach the goal, the following secondary tasks were pursued: (a) further enhancement of the CFN activity based on understanding their mode of action; (b) preparing efficient antimicrobial surfaces, investigating and optimizing their performance; (c) testing the efficacy of the antimicrobial surfaces in real food trials. Background to the topic The project dealt with reducing microbial food spoilage and safety hazards. Cross-contamination through food-contact surfaces is one of the major safety concerns, aggravated by bacterial biofilm formation. The project implemented nanotech methods to develop novel antimicrobial food-contact materials based on natural compounds. Food-grade phenylpropanoidcurcumin was chosen as the most promising active principle for this research. Major conclusions, solutions, achievements In agreement with the original plan, the following research tasks were performed. Optimization of particles structure and composition. Three types of curcumin-functionalizednanostructures were developed and tested: liposome-type polydiacetylenenanovesicles, surface- stabilized nanoparticles and methyl-β-cyclodextrin inclusion complexes (MBCD). The three types had similar minimal inhibitory concentration but different mode of action. Nanovesicles and inclusion complexes were bactericidal while the nanoparticlesbacteriostatic. The difference might be due to different paths of curcumin penetration into bacterial cell. Enhancing the antimicrobial efficacy of CFN by photosensitization. Light exposure strengthened the bactericidal efficacy of curcumin-MBCD inclusion complexes approximately three-fold and enhanced the bacterial death on curcumin-coated plastic surfaces. Investigating the mode of action of CFN. Toxicoproteomic study revealed oxidative stress in curcumin-treated cells of E. coli. In the dark, this effect was alleviated by cellular adaptive responses. Under light, the enhanced ROS burst overrode the cellular adaptive mechanisms, disrupted the iron metabolism and synthesis of Fe-S clusters, eventually leading to cell death. Developing industrially-feasible methods of binding CFN to food-contact surfaces. CFN binding methods were developed for various substrates: covalent binding (binding nanovesicles to glass, plastic and metal), sonochemical impregnation (binding nanoparticles to plastics) and electrostatic layer-by-layer coating (binding inclusion complexes to glass and plastics). Investigating the performance of CFN-coated surfaces. Flexible and rigid plastic materials and glass coated with CFN demonstrated bactericidal activity towards Gram-negative (E. coli) and Gram-positive (Bac. cereus) bacteria. In addition, CFN-impregnated plastic material inhibited bacterial attachment and biofilm development. Testing the efficacy of CFN in food preservation trials. Efficient cold pasteurization of tender coconut water inoculated with E. coli and Listeriamonocytogeneswas performed by circulation through a column filled with CFN-coated glass beads. Combination of curcumin coating with blue light prevented bacterial cross contamination of fresh-cut melons through plastic surfaces contaminated with E. coli or Bac. licheniformis. Furthermore, coating of strawberries with CFN reduced fruit spoilage during simulated transportation extending the shelf life by 2-3 days. Implications, both scientific and agricultural BARD Report - Project4680 Page 2 of 17 Antimicrobial food-contact nanomaterials based on natural active principles will preserve food quality and ensure safety. Understanding mode of antimicrobial action of curcumin will allow enhancing its dark efficacy, e.g. by targeting the microbial cellular adaptation mechanisms.
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