Literatura científica selecionada sobre o tema "Criblages"
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Artigos de revistas sobre o assunto "Criblages"
Meier, Roger, Magalie Mazelier e Pierre-Yves Lozach. "Criblages à haut débit d’ARN interférents". médecine/sciences 31, n.º 3 (março de 2015): 247–49. http://dx.doi.org/10.1051/medsci/20153103007.
Texto completo da fontePrudent, Renaud, Emmanuelle Soleilhac, Caroline Barette, Marie-Odile Fauvarque e Laurence Lafanechère. "Les criblages phénotypiques ou comment faire d’une pierre deux coups". médecine/sciences 29, n.º 10 (outubro de 2013): 897–905. http://dx.doi.org/10.1051/medsci/20132910018.
Texto completo da fonteChevalier, Florian, e Éric Maréchal. "Identification par deux criblages simultanés indépendants d’une famille d’inhibiteurs du métabolisme des glycérolipides". médecine/sciences 31, n.º 3 (março de 2015): 320–27. http://dx.doi.org/10.1051/medsci/20153103018.
Texto completo da fonteM'Sadak, Youssef, Mohamed Aymen Elouaer e Rim El Kamel. "Evaluation des substrats et des plants produits en pépinière forestière". BOIS & FORETS DES TROPIQUES 313, n.º 313 (1 de setembro de 2012): 61. http://dx.doi.org/10.19182/bft2012.313.a20497.
Texto completo da fonteKrimm, Isabelle. "Le criblage de fragments". médecine/sciences 31, n.º 2 (fevereiro de 2015): 197–202. http://dx.doi.org/10.1051/medsci/20153102017.
Texto completo da fonteBaratte, Blandine, Benoît Serive e Stéphane Bach. "Le criblage à Roscoff". médecine/sciences 31, n.º 5 (maio de 2015): 538–45. http://dx.doi.org/10.1051/medsci/20153105016.
Texto completo da fonteBashige, V. C., A. S. Bakari, B. J. Kahumba e J. B. S. Lumbu. "Activité antioxydante de 53 plantes réputées antimalariques en République Démocratique du Congo". Phytothérapie 19, n.º 5-6 (outubro de 2021): 355–71. http://dx.doi.org/10.3166/phyto-2021-0274.
Texto completo da fonteRognan, Didier, e Pascal Bonnet. "Les chimiothèques et le criblage virtuel". médecine/sciences 30, n.º 12 (dezembro de 2014): 1152–60. http://dx.doi.org/10.1051/medsci/20143012019.
Texto completo da fonteShabajee, Preety, Albane Gaudeau, Céline Legros, Thierry Dorval e Jean-Philippe Stéphan. "Du criblage à haut contenu à la déconvolution de cibles". médecine/sciences 37, n.º 3 (março de 2021): 249–57. http://dx.doi.org/10.1051/medsci/2021013.
Texto completo da fonteDumas, Jacques, Anne Sévérac, Cendrine Lemoine, Sylvain Huille, Alexey Rak e Catherine Prades. "Exemples d’études de développabilité apportant un éclairage à la prise de décision". médecine/sciences 35, n.º 12 (dezembro de 2019): 1171–74. http://dx.doi.org/10.1051/medsci/2019232.
Texto completo da fonteTeses / dissertações sobre o assunto "Criblages"
Autour, Alexis. "Amélioration et criblages de propriétés d'ARN aptamères fluorogènes en systèmes microfluidiques". Thesis, Strasbourg, 2018. http://www.theses.fr/2018STRAJ057.
Texto completo da fonteRNA is a key molecule in gene expression and its regulation. Therefore, being able to monitor RNA through live-cell imaging would represent an important step toward a better understanding of gene expression regulation. RNA-based fluorogenic modules are extremely promising tools to reach this goal. To this end, two light-up RNA aptamers (Spinach and Mango) display attractive properties but they suffer from a limited brightness. Since previous work in the group demonstrated the possibility to evolve RNA using microfluidic-assisted in vitro compartmentalization (µIVC), this technology appeared to be well suited to improve light-up aptamers properties by an evolution strategy. Therefore, the µIVC procedure was adapted to fluorogenic RNA aptamers to improve their properties (especially the brightness). Finally, using µIVC in tandem with high-throughput sequencing (NGS) allowed further developing the technology into a more integrated and semi-automatized approach in which RNAs and biosensors are selected by µIVC screening and the best variants identified by a bioinformatics process upon NGS analysis. To summarize, this thesis allowed establishing robust µIVC screening workflows for the discovery of novel efficient light-up RNA aptamers as well as metabolites biosensors
Giroux, Valentin. "Criblages systématiques de nouvelles cibles thérapeutiques dans le traitement du cancer pancréatique humain". Aix-Marseille 2, 2008. http://theses.univ-amu.fr.lama.univ-amu.fr/2008AIX22082.pdf.
Texto completo da fontePancreatic cancer is a disease with a very bleak prognosis despite important therapeutic efforts. The best chemotherapeutic agent, gemcitabine, is making a modest improvement of survival and has a very low response rate. The failure of current antitumoral strategies means that new targets possibilities must be explored. The cellular stress comprises of all events that disrupt cell homeostasis. The cell survival in response to stress involves activation of genes. The p8 protein is a stress protein induced by several stimuli and could therefore have a role in the resistance of pancreatic cancer. Here, we have demonstrated that the p8 protein is involved in resistance to gemcitabine in human pancreatic cancer cells. We have also described one of the mechanisms by which p8 regulates apoptosis by studying its interaction with the prothymosin α. There are more than 500 protein kinases in human cells which represent, by virtue of their central role in cell signaling, potential targets for the treatment of pancreatic cancer. Using a systematic screening of the human kinome, we obtained a catalogue of kinases involved in the survival of human pancreatic cancer cells. After selecting several candidates in this catalogue, we have demonstrated that their combined inhibition with siRNAs improves the induction of apoptosis in human pancreatic cancer cells in vitro and in intrapancreatic xenografts in a mouse model in vivo. This work opens up interesting perspectives for the use of new therapeutic targets for the treatment of pancreatic cancer
Colin, Boris. "Développement de méthodes de criblages et d'analyses en parallèle appliquées aux polymères modifiés silanes". Thesis, Rennes 1, 2015. http://www.theses.fr/2015REN1S145.
Texto completo da fonteThe aim of this work is to discover new catalytic systems to replace organotin compounds. The strategy used on our laboratory exploits tools of high throughput experiments to test a large number of catalysts in the same time in order to discover new catalytic systems more quickly
Macovei, Cristian-Paul. "Identification de catalyseurs à l'aide de criblages à haut débit basés sur des techniques immunoenzymatiques". Phd thesis, Université Paris Sud - Paris XI, 2008. http://tel.archives-ouvertes.fr/tel-00447202.
Texto completo da fonteHusson, Guillaume. "Développement de méthodes de criblages et en prallèle pour catalyse hétérogène de polymérisation d'oléfines gazeuses". Rennes 1, 2007. http://www.theses.fr/2010REN1S158.
Texto completo da fonteIn the first research part, two libraries of ligands have been synthesized in parallel and evaluated in olefin polymerization: bridged ligands for metallocenes and deprotonated carbonylamino fulvene ligands. This work led to the discovery of active systems in homogeneous and heterogeneous catalysis of polymerization. The second part is the development of new high-thoughput methods for heterogeneous catalysis of olefins polymerization. Sealed bags, where the supported catalysts are introduced and the polymer is formed, produce in parallel various polymers from several different catalytic systems. The multi-spot plates method allows a quick and simple evaluation of catalysts in gas-phase polymerization. Finally, the last part is the development of a new technique for viscosimetric analysis with optical tweezers applied to poly(sodium 4-styrene sulfonate) in water. Comparisons between rheology governed by empirical laws and microrheology have been conducted to validate this analysis method
Serve, Olivier. "Méthodologies de criblages d'interactions protéines-ligands par RMN : inhibitions de la Glms et de Bcl-xL". Paris 11, 2008. http://www.theses.fr/2008PA112134.
Texto completo da fonteThe versatility of Nuclear Magnetic Resonance (NMR) allows several applications in various domains. This versatility makes it a tool of prime importance in the field of therapeutic treatments research. It allows the determination of the structure and the dynamic of the interacting molecules. We used NMR on two proteins involved in diverse pathologies : Bcl-xL, partially responsible for the apoptosis deficiency for certain cancers, and the Glms, known to give complications to people affected with type II diabetes and target in the anti-microbial fight. The goal was to enhance our understanding of the interactions between those proteins and new molecules able to inhibit their activities. Those molecules are either extract from plants (Bcl-xL study), or synthesized (Glms study). Our results allowed to give orientations about the enhancements of the therapeutic effects of the studied molecules
Lienhart, Yann. "Analyse et exploitation de données de criblages de réactions chimiques pour la recherche de voies de synthèse". Strasbourg, 2011. http://www.theses.fr/2011STRA6223.
Texto completo da fonteChemistry databases are centered on chemicals and their reaction data is extracted from scientific literature. They are usually given in non-standardized conditions and in general nothing is available about reactions that did not occur or exhibit a low yield. Thus, it can be difficult to compare reactions and chemical transformations because of the specific experimental conditions and the missing data. This thesis has been funded by NovAlix (CIFRE), a company specialized in organic chemistry synthesis and structural biology. In order to explore the chemical space and improve the chemical synthesis process, two high-throughput reactions screening methods using gas chromatography and mass spectrometry have been set up in NovAlix. The Magellan information system developed during this thesis use a chemical reaction-centric database and is built on Java Enterprise Edition open-source technologies. It allows collecting high-throughput data from mass spectrometry and gas chromatography experimentations realized in standardized conditions. Then, the Magellan application enables the chemist to read and store experimental results, provides tools to help data analysis and query the collected data via a rich-client user interface
Navarri, Marion. "Métabolites secondaires de champignons de sédiments marins profonds : criblages génétique et fonctionnel et caractérisation structurale de molécules antimicrobiennes". Thesis, Brest, 2016. http://www.theses.fr/2016BRES0127/document.
Texto completo da fonteThe spreading of antimicrobial resistant microorganisms jeopardizes global health caresystem. To counteract this threat the renewal of antibiotic molecules is a global priority. Antibioticcompounds are mainly originated from microorganisms, so microorganisms and their secondarymetabolites received an increasing interest. The search for new natural antimicrobial compoundsfrom microorganisms gained untapped ecosystems as marine biosphere.We investigated the antimicrobial properties of a fungal collection. The 183 fungal isolateswere collected from deep subseafloor sediment and isolated between 4 and 1,884 meters belowthe seafloor. Secondary metabolites production potential was studied for all isolates in thecollection by screening genes coding PolyKetide Synthase (PKS), Non-Ribosomal Peptide Synthetase(NRPS), TerPene Synthase (TPS) and hybrid PKS-NRPS. After isolates dereplication according to theirMSP-PCR fingerprinting, an antimicrobial screening was performed for 110 isolates, highlighting ahigh proportion of filamentous fungi with antimicrobial properties (32%).After extraction and bio-guided fractionation bioactive metabolites isolated from 3 strains,were characterized in a structural and functional manner: O. griseum UBOCC-A-114129 producedfuscin, dihydrofuscin, secofuscin and dihydrosecofuscine, P. bialowiezense UBOCC-A-114097synthetized mycophenolic acid and Penicillium sp. UBOCC-A-114109 produced rugulosin.In the meantime, LC-HRMS analysis, performed on fungal extracts, showed a great proportionof metabolites not detected in interrogated databases. So, deep subseafloor fungi, represent anuntapped reservoir of original structures to explore
Giganti, David. "Etudes structurales et criblages in silico de chimiothèques sur des cibles thérapeutiques de plasmodium falciparum et mycobacterium tuberculosis". Paris 7, 2008. http://www.theses.fr/2008PA077243.
Texto completo da fonteNowadays, the identification of leads from a therapeutic target becomes a classic pipeline for drug discovery. In silico virtual screening approaches, based on this target structure allow the enrichment of a large compounds databank in a significantly reduced subset. This selection involves a docking procedure, for each compound, which predicts their binding mode to the target and their affinity, in order to classify them. Finally, the experimental validation of these relevant compounds is a performing substitute to a costly High-Throughput Screening. On two collaborative projects at Institut Pasteur, we apply a structure-based screening to help antimalarial and antituberculous leads finding. The therapeutic target SUB2 is an essential protease in the erythrocyte invasion. We successfully manage to identify compounds able to inhibit its activity, in vitro. Since no experimental structure of SUB2 is available, the screening required a prior comparative modeling of the P. Falciparum on homologous bacterial proteins. The second project concerna PimA, a fundamental glycosyltransférase for the construction of the mycobacteria cell wall. In contract to SUB2, the virtual screening process take advantage of the recent structure frorn PimA crystal and lead the determination of promising inhibitors. For both projects, we also initiate a optimization campaign based on the understanding of the inhibitory mecanism of the leads in the aim to design their chemical structure. Improvement of their efficiency is indeed necessary at this point of the preclinical step. We also study the non specific and superficial association of these enzymes to the plasmatic membrane
Maréchal, Xavier. "Développement d'inhibiteurs du protéasome à visée pharmacologique : élaboration rationnelle, criblages de collections de molécules et évaluation biologique sur des modèles cellulaires". Paris 6, 2011. http://www.theses.fr/2011PA066351.
Texto completo da fonteLivros sobre o assunto "Criblages"
Claire, Kanyange Marie. Criblage de quelques variétés selectionnées de haricot commun pour la résistance a l'anthracnose. Butare [Rwanda]: Université nationale du Rwanda, Faculté d'agronomie, 2001.
Encontre o texto completo da fonteJörg, Hüser, ed. High-throughput screening in drug discovery. Weinheim: Wiley-VCH, 2006.
Encontre o texto completo da fonteP, Janzen William, ed. High throughput screening: Methods and protocols. Totowa, N.J: Humana Press, 2002.
Encontre o texto completo da fonteMatson, Robert S. Applying genomic and proteomic microarray technology in drug discovery. Boca Raton: CRC Press, 2005.
Encontre o texto completo da fonteTushar, Kshirsagar, ed. High-throughput lead optimization in drug discovery. Boca Raton: CRC Press, 2008.
Encontre o texto completo da fonteFolkers, Gerd, Raimund Mannhold, Hugo Kubinyi e J�rg H�ser. High-Throughput Screening in Drug Discovery. Wiley & Sons, Incorporated, John, 2006.
Encontre o texto completo da fonteHigh-Throughput Screening in Drug Discovery (Methods and Principles in Medicinal Chemistry). Wiley-VCH, 2006.
Encontre o texto completo da fonteFolkers, Gerd, Raimund Mannhold, Hugo Kubinyi e J�rg H�ser. High-Throughput Screening in Drug Discovery. Wiley & Sons, Limited, John, 2006.
Encontre o texto completo da fonteCzarnik, Anthony W., e Houng-Yau Mei. Integrated Drug Discovery Technologies. Taylor & Francis Group, 2019.
Encontre o texto completo da fonteCzarnik, Anthony W., e Houng-Yau Mei. Integrated Drug Discovery Technologies. CRC, 2002.
Encontre o texto completo da fonteCapítulos de livros sobre o assunto "Criblages"
Garrigues, Philippes. "Chapitre 7 : Techniques analytiques : criblages, modélisation, biomarqueurs et spéciation". In Chimie et expertise, 99–118. EDP Sciences, 2020. http://dx.doi.org/10.1051/978-2-7598-1996-6-010.
Texto completo da fonteGarrigues, Philippes. "Chapitre 7 : Techniques analytiques : criblages, modélisation, biomarqueurs et spéciation". In Chimie et expertise, 99–118. EDP Sciences, 2020. http://dx.doi.org/10.1051/978-2-7598-1996-6.c010.
Texto completo da fontePeetrons, P. "Injection intratendineuse de plasma riche en plaquettes et criblage percutané". In Infiltrations échoguidées, 29–34. Elsevier, 2012. http://dx.doi.org/10.1016/b978-2-294-71586-0.00004-2.
Texto completo da fonte