Literatura científica selecionada sobre o tema "Conception de médicaments assistée par ordinateur"
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Artigos de revistas sobre o assunto "Conception de médicaments assistée par ordinateur"
Vanhelst, Pierre. "Conception assistée par ordinateur et relations acheteur-fournisseur". Décisions Marketing 4 (1 de janeiro de 1995): 73–78. http://dx.doi.org/10.7193/dm.004.73.78.
Texto completo da fonteBarache, J. M., G. Beltranda, P. Blanc e J. Pinoteau. "VII - Les moyens de conception assistée par ordinateur". Revue Générale Nucléaire, n.º 2 (março de 1987): 198–200. http://dx.doi.org/10.1051/rgn/19872198.
Texto completo da fonteVanhelst, Pierre. "Conception assistée par ordinateur et relations acheteur-fournisseur". Décisions Marketing N° 4, n.º 1 (1 de janeiro de 1995): 73–78. http://dx.doi.org/10.3917/dm.04.0073.
Texto completo da fonteRumelhard, Christian, Yves Archambault e Isabelle Telliez. "Conception assistée par ordinateur des circuits intégrés monolithiques hyperfréquences". Annales des Télécommunications 43, n.º 7-8 (julho de 1988): 434–42. http://dx.doi.org/10.1007/bf02999713.
Texto completo da fonteHégron, Gérard. "De la modélisation à la conception assistée par ordinateur". Annales des Ponts et Chaussées 2003, n.º 107-108 (julho de 2003): 19–26. http://dx.doi.org/10.1016/s0152-9668(03)80004-9.
Texto completo da fontedeVathaire, M., E. Liégeon, G. Mennel e A. Faesse. "Conception assistée par ordinateur : application au laminage des produits longs". Revue de Métallurgie 82, n.º 5 (maio de 1985): 387–98. http://dx.doi.org/10.1051/metal/198582050387.
Texto completo da fonteLincelles, JB, V. Goiffon e M. Respauda. "Apprentissage de la conception de circuits intégrés : une introduction par la technologie à l’aide d’un logiciel de TCAD". J3eA 21 (2022): 1010. http://dx.doi.org/10.1051/j3ea/20221010.
Texto completo da fonteSatori, K., e B. El Kihel. "Étude et modélisation des mécanismes complexes en conception assistée par ordinateur". Journal de Physique III 7, n.º 11 (novembro de 1997): 2211–23. http://dx.doi.org/10.1051/jp3:1997253.
Texto completo da fonteTap, H., R. P. Tan, O. Bernal, P.-F. Calmon, C. Rouabhi, C. Capello, J. Schauber et al. "Du silicium au circuit CMOS. Pédagogie active par Apprentissage Par Projet". J3eA 23 (2024): 1019. http://dx.doi.org/10.1051/j3ea/20241019.
Texto completo da fonteRagavan, R., A. Laferrière, D. Dumont, P. Rondot, P. Benoît e F. Ohanna. "Les coussins anti-escarres de type ≪conception assistée par ordinateur≫: Expérience préliminaire". Annales de Réadaptation et de Médecine Physique 40, n.º 6 (janeiro de 1997): 419–20. http://dx.doi.org/10.1016/s0168-6054(97)85418-9.
Texto completo da fonteTeses / dissertações sobre o assunto "Conception de médicaments assistée par ordinateur"
Minoux, Hervé. "Étude et conception assistées par ordinateur d'antagonistes des intégrines de la famille beta 3". Nancy 1, 1998. http://www.theses.fr/1998NAN10260.
Texto completo da fonteSperandio, Olivier. "Applications et développements informatiques de protocoles de drug design et criblage virtuel". Paris 5, 2007. http://www.theses.fr/2007PA05P612.
Texto completo da fonteThis thesis in structural bioinformatics and chemoinformatics concentrates on the optimization of the therapeutics compounds identification process. It relies on the three main components of the chemical compounds virtual screening: preparation of a computational version of the chemical library to be screened; identification of novel active compounds using chemical similarity with respect to known active molecules (LBVS); and identification of novel active compounds using the 3D structure of the target binding site (SBVS). This work implied: to develop a computer program (MED-3DMC) that generates conformation ensembles of small molecules ; then to create a LBVS program (MED-SuMoLig) that can screen thousands of chemical compounds using their pharmaco-topological profile; and finally to use a hierarchical SBVS procedure to identify novel inhibitors for protein-membrane interaction using the coagulation factor Va as a proof of concept
Muller, Pascal. "Criblage virtuel inverse : validation et applications". Strasbourg 1, 2006. http://www.theses.fr/2006STR13137.
Texto completo da fonteThe conception of bioactive molecules uses more and more in silico methods. Discovering which ligands, out of a large library, are likely to bind to a protein of interest is slowly turning into routine computational chemistry. Surprisingly, the opposite question is still an issue. Given a known ligand, is it possible to recover its most likely target(s)? Answering this question using the above mentioned docking approach implies the development of a collection of protein active sites. As a database of choice to develop the inverse virtual screening (IVS) procedure, we have chosen the Protein Data Bank. We extracted from the PDB a target library, the sc-PDB. It is a collection of three-dimensional structures of active sites. I contributed to validate the IVS procedure: it is able to find known targets of ligands. In the process of sc-PDB update, I developed an algorithm able to accurately identify protein-ligand complex. I used IVS procedure to discover targets for new molecules: chemists wanted to know if the chemical space of their combinatorial library matches pharmaceutical targets. Five targets were selected in silico, and two targets were validated in vitro. The sc-PDB library and IVS procedure are powerful tools, and the simplicity of the approach makes it particularly attractive for prioritizing a few targets for experimental validation, and is therefore a good complement to experimental target identification strategies
Hoffer, Laurent. "Développement et validation du logiciel S4MPLE : application au docking moléculaire et à l'optimisation de fragments assistée par ordinateur dans le cadre du fragment-based drug design". Phd thesis, Université de Strasbourg, 2013. http://tel.archives-ouvertes.fr/tel-00874644.
Texto completo da fonteConvard, Thomas. "Conception assistée par ordinateur en environnement immersif". Paris 11, 2005. http://www.theses.fr/2005PA112249.
Texto completo da fonteThis thesis discuss of the use of immersive environments of Virtual Reality (VR) for Computer Aided Design (CAD). We study how these new interfaces between man and information systems can improve the different tasks of geometric shape design that are actually done on workstation with screen. These workstations essentially use keyboard, mouse and graphical interface. However this kind of interaction does not take advantage of VR possibilities in term of direct 3d interaction. In addition, CAD objects does not allow ways to modify there shape with a direct and 3d interaction. We present an approach of reactive objects that allows changing the value of operations parameters in the construction history graph of the solid, from direct interaction of the user on the elements (vertex, edge, face) of the B-Rep of the solid. To this purpose, we use an inference system that decides what parameters to modify knowing the selected element, and how to map the manipulations of the user to numerical changes of the parameters. These inferences are based on sets of rules dealing with construction information attached to the elements of B-Rep. This model of reactive objects has been implemented in a software prototype allowing creation and modification of CAD objects in an intuitive way. The interface proposed is a multimodal and immersive environment. We also propose in this thesis a method for collision detection dedicated to immersive interaction and a graphic rendering system on PC cluster adapted to deformable objects
Touir, Maatallah. "Conception des canaux assistée par ordinateur CCAO". Master's thesis, Université Laval, 1996. http://hdl.handle.net/20.500.11794/28418.
Texto completo da fonteFarag, Marc. "Conception assistée par ordinateur d'inhibiteurs de XIAP". Electronic Thesis or Diss., Normandie, 2023. http://www.theses.fr/2023NORMC264.
Texto completo da fonteSince their discovery, protein-protein interactions (PPIs) have been at the heart of many biological processes. These PPIs can be drug targets, either by mimicking a defective interaction or by inhibiting an inadequate interaction. Among the most implicated PPIs in pathologies, we found the Inhibitor Apoptosis Proteins (AAPs). These members are considered as key regulators of programmed cell death and, within the cell signalling pathways, XIAP, a member of the IAP family, is one of the most targeted proteins actually. Its involvement in cancers and rare inflammatory diseases makes it a therapeutic target of choice. Recent data in the literature have highlighted the importance of designing selective disruptors for this protein in order to avoid serious adverse effects. For this reason, it is essential to know the essential structural elements associated with the different domains of this protein, which distinguish it from other similar members of the IAP family. It is also essential to know the interaction mechanisms in which XIAP is involved with its partners. CADD tools, in particular the Structure-based drug design approach, as well as experimental evaluation techniques using fluorescence anisotropy (FPA) or AlphaScreen® technology were used as part of this thesis work. The results of in silico and in vitro work led to rational design proposals of selective small molecules that could potentially disrupt XIAP-mediated PPIs
Seignole, Jean-François. "Conception assistée par ordinateur de liaisons par fibres optiques". Limoges, 1991. http://www.theses.fr/1991LIMO0115.
Texto completo da fonteDelchambre, Alain. "Conception assistée par ordinateur de gammes opératoires d'assemblage". Doctoral thesis, Universite Libre de Bruxelles, 1990. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/213146.
Texto completo da fonteTayyar, Ahmad. "Une méthode de géodésie assistée par ordinateur". Mulhouse, 1991. http://www.theses.fr/1991MULH0199.
Texto completo da fonteLivros sobre o assunto "Conception de médicaments assistée par ordinateur"
Paul, Quintrand, ed. La Conception assistée par ordinateur en architecture. Paris: Hermès, 1985.
Encontre o texto completo da fonteLoyer, Michel. La CAO - Le DAO. Paris: Presses universitaires de France, 1991.
Encontre o texto completo da fonteRisler, Jean-Jacques. Méthodes mathématiques pour la CAO. Paris: Masson, 1991.
Encontre o texto completo da fonteBoulicot, Claude. C.A.O.: Choix, mise en place et pratique. Paris: Eyrolles, 1989.
Encontre o texto completo da fonteRiopel, Martin. Conception et mises à l'essai d'un environnement d'apprentissage intégrant l'expérimentation assistée par ordinateur et la simulation assistée par ordinateur. [Repentigny, QC]: Martin Riopel, 2005.
Encontre o texto completo da fonteMeyer, J. J. 3 D et vrai relief: Images de synthèse. Paris: Editions Radio, 1986.
Encontre o texto completo da fonteVonk, Roland. Prototypage: L'utilisation efficace de la technologie CASE. Paris: Masson, 1992.
Encontre o texto completo da fonteLewis, T. G. CASE: Computer-aided software engineering. New York: Van Nostrand Reinhold, 1991.
Encontre o texto completo da fonteBonnardel, Nathalie. Créativité et conception: Approches cognitives et ergonomiques. Marseille: Solal, 2006.
Encontre o texto completo da fonteGordon, Bob. Le guide pratique du design graphique et numérique: Agrémenté de 531 illustrations. Paris: Pyramid, 2002.
Encontre o texto completo da fonteCapítulos de livros sobre o assunto "Conception de médicaments assistée par ordinateur"
Arrué, J., B. Moreno e J. P. Chavoin. "Conception assistée par ordinateur et reconstruction des parois". In Chirurgie plastique et reconstructrice des parois et des confins, 39–56. Elsevier, 2009. http://dx.doi.org/10.1016/b978-2-294-70949-4.50003-7.
Texto completo da fonteTrabalhos de conferências sobre o assunto "Conception de médicaments assistée par ordinateur"
Elmoutawakkil, N., S. Bouzoubaa, S. Bellemkhannate e I. Benyahya. "Flux de travail du guidage tridimensionnel en chirurgie orale". In 66ème Congrès de la SFCO. Les Ulis, France: EDP Sciences, 2020. http://dx.doi.org/10.1051/sfco/20206602005.
Texto completo da fonte