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Macnair, R., M. J. Underwood e G. D. Angelini. "Biomaterials and cardiovascular devices". Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine 212, n.º 6 (1 de junho de 1998): 465–71. http://dx.doi.org/10.1243/0954411981534222.
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In the field of cardiovascular surgery there is presently a lack of biomaterials possessing essential characteristics of the native tissue or organ which is to be replaced. This paper describes various biomaterials that have been introduced into the circulatory system and the complex reactions that subsequently occur. The risk of infection is also discussed as well as prevention and treatment regimes that can be used. Examples of future biomaterial development are outlined in an attempt to achieve biocompatibility.
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BALTATU, Madalina Simona, Petrica VIZUREANU, Andrei Victor SANDU, Iustinian BALTATU, Doru Dumitru BURDUHOS-NERGIS e Marcelin BENCHEA. "PROSPECTS ON TITANIUM BIOMATERIALS". European Journal of Materials Science and Engineering 8, n.º 4 (20 de dezembro de 2023): 201–12. http://dx.doi.org/10.36868/ejmse.2023.08.04.201.
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Biomaterials are substances that have been engineered to interact with biological systems for a medical purpose, either a therapeutic or diagnostic one. Biomaterials have a rich history of evolution, as they have continuously transformed from simple inert substances to complex, interactive materials, designed to communicate with biological systems and promote tissue regeneration and healing. Titanium, due to its excellent biocompatibility, corrosion resistance, and mechanical properties, has established its place as one of the most used biomaterials, particularly in orthopedics and dental applications. This article provides an overview of titanium as a biomaterial, highlighting its properties, applications, and recent advancements.
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Petković, Dušan, Miloš Madić e Goran Radenković. "Knee Prosthesis Biomaterial Selection by Using MCDM Solver". Advanced Technologies & Materials 46, n.º 2 (15 de dezembro de 2021): 37–41. http://dx.doi.org/10.24867/atm-2021-2-006.
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Biomaterials are a special class of contemporary materials used to make prostheses, parts of organs or to replace entire organs. They are used to replace soft and hard tissues. Metal biomaterials are mostly used to replace hard bone tissues and joints. There is no ideal substitution for natural biological material, but each of the biomaterials has a number of advantages and disadvantages. The problem of choosing the most favorable biomaterial is a complex process of multi‐criteria decision‐making, which requires a lot of knowledge and experience. In order to help decision makers in solving this complex task, a decision support system named MCDM Solver is proposed. MCDM Solver is used in decision‐making process to rank the biomaterials with respect to several criteria. In this paper, MCDM Solver was used to select knee prosthesis material.
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Leeuwenburgh, Sander. "Self-healing biomaterials for medical applications". MATEC Web of Conferences 378 (2023): 01003. http://dx.doi.org/10.1051/matecconf/202337801003.
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Biomaterials are currently applied in increasingly complex areas such as tissue engineering, bioprinting and regenerative medicine. To this end, challenging combinations of biomaterial properties are required which usually cannot be met by conventional biomaterials. Since the early 2000s, several new concepts have been proposed to render biomaterials self-healing in order to improve the functionality of traditional biomaterials in terms of their mechanical, handling and biological properties. This presentation will provide a comprehensive overview of the field of self-healing biomaterials, ranging from self-healing of capsule-filled dental fillers and bone cements, to the self-healing behavior of modern injectable hydrogels used in regenerative medicine. More specifically, the presentation will highlight why self-healing properties of biomaterials are crucial for minimally invasive injection into the human body and achieve successful tissue regeneration.
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Kim, Alexia, Mauricio A. Downer, Charlotte E. Berry, Caleb Valencia, Alex Z. Fazilat e Michelle Griffin. "Investigating Immunomodulatory Biomaterials for Preventing the Foreign Body Response". Bioengineering 10, n.º 12 (11 de dezembro de 2023): 1411. http://dx.doi.org/10.3390/bioengineering10121411.
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Implantable biomaterials represent the forefront of regenerative medicine, providing platforms and vessels for delivering a creative range of therapeutic benefits in diverse disease contexts. However, the chronic damage resulting from implant rejection tends to outweigh the intended healing benefits, presenting a considerable challenge when implementing treatment-based biomaterials. In response to implant rejection, proinflammatory macrophages and activated fibroblasts contribute to a synergistically destructive process of uncontrolled inflammation and excessive fibrosis. Understanding the complex biomaterial–host cell interactions that occur within the tissue microenvironment is crucial for the development of therapeutic biomaterials that promote tissue integration and minimize the foreign body response. Recent modifications of specific material properties enhance the immunomodulatory capabilities of the biomaterial and actively aid in taming the immune response by tuning interactions with the surrounding microenvironment either directly or indirectly. By incorporating modifications that amplify anti-inflammatory and pro-regenerative mechanisms, biomaterials can be optimized to maximize their healing benefits in harmony with the host immune system.
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Chow, Lesley W., e Jacob F. Fischer. "Creating biomaterials with spatially organized functionality". Experimental Biology and Medicine 241, n.º 10 (maio de 2016): 1025–32. http://dx.doi.org/10.1177/1535370216648023.
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Biomaterials for tissue engineering provide scaffolds to support cells and guide tissue regeneration. Despite significant advances in biomaterials design and fabrication techniques, engineered tissue constructs remain functionally inferior to native tissues. This is largely due to the inability to recreate the complex and dynamic hierarchical organization of the extracellular matrix components, which is intimately linked to a tissue’s biological function. This review discusses current state-of-the-art strategies to control the spatial presentation of physical and biochemical cues within a biomaterial to recapitulate native tissue organization and function.
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PRESTWICH, GLENN D., e HOWARD MATTHEW. "Hybrid, Composite, and Complex Biomaterials". Annals of the New York Academy of Sciences 961, n.º 1 (junho de 2002): 106–8. http://dx.doi.org/10.1111/j.1749-6632.2002.tb03058.x.
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Bettinger, Christopher J. "Synthesis and microfabrication of biomaterials for soft-tissue engineering". Pure and Applied Chemistry 81, n.º 12 (31 de outubro de 2009): 2183–201. http://dx.doi.org/10.1351/pac-con-09-07-10.
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Biomaterials synthesis and scaffold fabrication will play an increasingly important role in the design of systems for regenerative medicine and tissue engineering. These rapidly growing fields are converging as scaffold design must begin to incorporate multidisciplinary aspects in order to effectively organize cell-seeded constructs into functional tissue. This review article examines the use of synthetic biomaterials and fabrication strategies across length scales with the ultimate goal of guiding cell function and directing tissue formation. This discussion is parsed into three subsections: (1) biomaterials synthesis, including elastomers and gels; (2) synthetic micro- and nanostructures for engineering the cell–biomaterial interface; and (3) complex biomaterials systems design for controlling aspects of the cellular microenvironment.
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Sask, Kyla N., Bruce Thong, Negar Goodarzynejad, Leslie R. Berry e Anthony K. C. Chan. "Immunospecific analysis of in vitro and ex vivo surface-immobilized protein complex". Biointerphases 17, n.º 2 (março de 2022): 021005. http://dx.doi.org/10.1116/6.0001783.
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Biomaterials used for blood contacting devices are inherently thrombogenic. Antithrombotic agents can be used as surface modifiers on biomaterials to reduce thrombus formation on the surface and to maintain device efficacy. For quality control and to assess the effectiveness of immobilization strategies, it is necessary to quantify the surface-immobilized antithrombotic agent directly. There are limited methods that allow direct quantification on device surfaces such as catheters. In this study, an enzyme immunoassay (EIA) has been developed to measure the density of a synthetic antithrombin-heparin (ATH) covalent complex immobilized on a catheter surface. The distribution of the immobilized ATH was further characterized by an immunohistochemical assay. This analyte-specific EIA is relatively simple and has high throughput, thus providing a tool for quantitative analysis of biomaterial surface modifications. These methods may be further modified to evaluate plasma proteins adsorbed and immobilized on various biomaterial surfaces of complex shapes, with a range of bioactive functionalities, as well as to assess conformational changes of proteins using specific antibodies.
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Honig, Floris, Steven Vermeulen, Amir A. Zadpoor, Jan de Boer e Lidy E. Fratila-Apachitei. "Natural Architectures for Tissue Engineering and Regenerative Medicine". Journal of Functional Biomaterials 11, n.º 3 (7 de julho de 2020): 47. http://dx.doi.org/10.3390/jfb11030047.
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The ability to control the interactions between functional biomaterials and biological systems is of great importance for tissue engineering and regenerative medicine. However, the underlying mechanisms defining the interplay between biomaterial properties and the human body are complex. Therefore, a key challenge is to design biomaterials that mimic the in vivo microenvironment. Over millions of years, nature has produced a wide variety of biological materials optimised for distinct functions, ranging from the extracellular matrix (ECM) for structural and biochemical support of cells to the holy lotus with special wettability for self-cleaning effects. Many of these systems found in biology possess unique surface properties recognised to regulate cell behaviour. Integration of such natural surface properties in biomaterials can bring about novel cell responses in vitro and provide greater insights into the processes occurring at the cell-biomaterial interface. Using natural surfaces as templates for bioinspired design can stimulate progress in the field of regenerative medicine, tissue engineering and biomaterials science. This literature review aims to combine the state-of-the-art knowledge in natural and nature-inspired surfaces, with an emphasis on material properties known to affect cell behaviour.
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Agrawal, Ishita, e Piyush Dua. "Surface Modification of Advanced Biomaterials for Applications in the Pharmaceutical and Medical Fields". Biotechnology Kiosk 4, n.º 3 (21 de março de 2022): 1–16. http://dx.doi.org/10.37756/bk.22.4.3.1.
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Lately, there has been a great deal of emphasis on developing novel biomaterials for next generation biomedical technologies. Especially, research efforts have focused on biomaterials that meet the demand for precisely engineered three-dimensional structures. These research efforts seek to design advanced biomaterials that mimic the natural environments of tissues more closely, and thus enhance the functional performance of these materials. To this end, surface modification/functionalization of biomaterials is considered pivotal to achieve the goals. Recent progress in biomaterials fabrication techniques has shown huge promise for surface engineering of biomaterials leading to realization of devices that have complex surface geometries for various biomedical applications in the pharmaceutical and medical fields. These include next generation drug delivery, diagnosis and biosensors, to name a few. In this review, we have highlighted important surface modification processes that have been employed for surface engineering of biomaterials. Further, an overview of the cellular response of surface modified biomaterial is presented. We have also discussed precise engineering of three-dimensional surface modification of biomaterials by initiated chemical vapor deposition (i-CVD) method. Notable biomedical applications have been described. Finally, we have presented a brief future perspective.
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James, Roshan, Paulos Mengsteab e Cato T. Laurencin. "Regenerative Engineering: Studies of the Rotator Cuff and other Musculoskeletal Soft Tissues". MRS Advances 1, n.º 18 (2016): 1255–63. http://dx.doi.org/10.1557/adv.2016.282.
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ABSTRACT‘Regenerative Engineering’ is the integration of advanced materials science, stem cell science, physics, developmental biology and clinical translation to regenerate complex tissues and organ systems. Advanced biomaterial and stem cell science converge as mechanisms to guide regeneration and the development of prescribed cell lineages from undifferentiated stem cell populations. Studies in somite development and tissue specification have provided significant insight into pathways of biological regulation responsible for tissue determination, especially morphogen gradients, and paracrine and contact-dependent signaling. The understanding of developmental biology mechanisms are shifting the biomaterial design paradigm by the incorporation of molecules into scaffold design and biomaterial development that are specifically targeted to promote the regeneration of soft tissues. Our understanding allows the selective control of cell sensitivity, and a temporal and spatial arrangement to modulate the wound healing mechanism, and the development of cell phenotype leading to the patterning of distinct and multi-scale tissue systems.Building on the development of mechanically compliant novel biomaterials, the integration of spatiotemporal control of biological, chemical and mechanical cues helps to modulate the stem cell niche and direct the differentiation of stem cell lineages. We have developed advanced biomaterials and biomimetic scaffold designs that can recapitulate the native tissue structure and mechanical compliance of soft musculoskeletal tissues, such as woven scaffold systems for ACL regeneration, non-woven scaffolds for rotator cuff tendon augmentation, and porous elastomers for regeneration of muscle tissue. Studies have clearly demonstrated the modulation of stem cell response to bulk biomaterial properties, such as toughness and elasticity, and scaffold structure, such as nanoscale and microscale dimensions. The integration of biological cues inspired from our understanding of developmental biology, along with chemical, mechanical and electrical stimulation drives our development of novel biomaterials aimed at specifying the stem cell lineage within 3-dimensional (3D) tissue systems. This talk will cover the development of biological cues, advanced biomaterials, and scaffold designs for the regeneration of complex soft musculoskeletal tissue systems such as ligament, tendon, and muscle.
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Hakim, Lotfollah Kamali, Mohsen Yazdanian, Mostafa Alam, Kamyar Abbasi, Hamid Tebyaniyan, Elahe Tahmasebi, Danial Khayatan, Alexander Seifalian, Reza Ranjbar e Alireza Yazdanian. "Biocompatible and Biomaterials Application in Drug Delivery System in Oral Cavity". Evidence-Based Complementary and Alternative Medicine 2021 (13 de novembro de 2021): 1–12. http://dx.doi.org/10.1155/2021/9011226.
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Biomaterials applications have rapidly expanded into different fields of sciences. One of the important fields of using biomaterials is dentistry, which can facilitate implantation, surgery, and treatment of oral diseases such as peri-implantitis, periodontitis, and other dental problems. Drug delivery systems based on biocompatible materials play a vital role in the release of drugs into aim tissues of the oral cavity with minimum side effects. Therefore, scientists have studied various delivery systems to improve the efficacy and acceptability of therapeutic approaches in dental problems and oral diseases. Also, biomaterials could be utilized as carriers in biocompatible drug delivery systems. For instance, natural polymeric substances, such as gelatin, chitosan, calcium phosphate, alginate, and xanthan gum are used to prepare different forms of delivery systems. In addition, some alloys are conducted in drug complexes for the better in transportation. Delivery systems based on biomaterials are provided with different strategies, although individual biomaterial has advantages and disadvantages which have a significant influence on transportation of complex such as solubility in physiological environments or distribution in tissues. Biomaterials have antibacterial and anti-inflammatory effects and prolonged time contact and even enhance antibiotic activities in oral infections. Moreover, these biomaterials are commonly prepared in some forms such as particulate complex, fibers, microspheres, gels, hydrogels, and injectable systems. In this review, we examined the application of biocompatible materials in drug delivery systems of oral and dental diseases or problems.
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Stamboliev, I. A., Julia Vladimirovna Gazhva, S. G. Ivashkevich e V. M. Ryabova. "CURRENT APPROACHES OF BONE TISSUE ENGINEERING". Russian Journal of Dentistry 22, n.º 2 (15 de abril de 2018): 111–16. http://dx.doi.org/10.18821/1728-2802-2018-22-2-111-116.
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This article discusses the modern approaches of bone tissue engineering in oral and maxillofacial surgery for repair of bone integrity. Describes the new biomaterials in bone tissue engineering, complex scaffolds containing MSC for bone repair of large and critical bone defects, the criteria for selecting biomaterial scaffolds, as well as their positive and negative properties.
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Aminov, Liana, Eusebiu Viorel Sindilar, Aurelian Sorin Pasca, Cristina Antohi, Yllka Decolli, Ovidiu Stamatin, Lupu Iulian Costin et al. "In Vivo Evaluation of Biocompatibility of Three Biomaterials Used in Endodontics for Prosthetic Purposes in Complex Rehabilitation Treatment". Applied Sciences 11, n.º 14 (15 de julho de 2021): 6519. http://dx.doi.org/10.3390/app11146519.
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The ideal biomaterial used in endodontics in the process of sealing the radicular canals should possess a group of qualities for a predictable outcome: biocompatibility, initiation of ontogenesis and cementogenesis, ease of handling, sufficient manipulation time, and convenient price. For a perfect sealing, the root canal treatment can be followed by prosthetic restoration. This study of biocompatibility aims to determine the quantification of the local reaction following the implantation of three biomaterials in the rabbit subcutaneous connective tissue. The used biomaterials with particular reparative properties are: MTA (Mineral Trioxide Aggregate, Dentsply, Tulsa Dental, Johnson City, TN, USA), Sealapex (Kerr, Switzerland), and DiaRoot BioAggregate (Innovative BioCaramix Inc, Vancouver, BC, Canada). The first two biomaterials (MTA, Sealapex) are already being used in endodontic treatments, and the latter was newly introduced during the concrete development of the study. This is an experimental study focused on qualitative and quantitative analysis based on histopathological examination and underlined by the positive result of the study undertaken of the applicability of oral rehabilitation treatments, increasing patients’ quality of life by a significant proportion of 95%, and generating optimal functionality of the stomatognathic system with prosthetic devices as well as accomplishing the objectives of homeostasis.
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Gristina, A. G., G. Giridhar, B. L. Gabriel, P. T. Naylor e Q. N. Myrvik. "Cell Biology and Molecular Mechanisms in Artificial Device Infections". International Journal of Artificial Organs 16, n.º 11 (novembro de 1993): 755–64. http://dx.doi.org/10.1177/039139889301601103.
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Biomaterials are being used with increasing frequency for tissue substitution. Complex devices such as total joint replacement and the total artificial heart represent combinations of polymers and metal alloys for system and organ replacement. The major barrier to the extended use of these devices is bacterial adhesion to biomaterials, which causes biomaterial-centered infection, and the lack of successful tissue integration or compatibility with biomaterial surfaces. Adhesion-mediated infections are extremely resistant to antibiotics and host defenses and frequently persist until the biomaterial or foreign body is removed. The pathogenesis of adhesive infections is related, in part, to preferential colonization of “inert” substrata whose surfaces are not integrated with healthy tissues composed of living cells and intact extracellular polymers. Tissue integration is an interesting parallel to microbial adhesion and is a desired phenomenon for the biocompatibility of certain implants and biomaterials. Tissue integration requires a form of eukaryocytic adhesion or compatibility with possible chemical integration to an implant surface. Many of the fundamental principles of interfacial science apply to both microbial adhesion and to tissue integration and are general to and independent of the substratum materials involved. Interactions of biomaterials with bacteria and tissue cells are directed not only by specific receptors and outer membrane molecules on the cell surface, but also by the atomic geometry and electronic state of the biomaterial surface. An understanding of these mechanisms is important to all fields of medicine and is derived from and relevant to studies in microbiology, biochemistry, and physics. Modifications of biomaterial surfaces at an atomic level will allow the programming of cell-to-substratum events, thereby diminishing infection by enhancing tissue compatibility or integration, or by directly inhibiting bacterial adhesion.
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Chaudhry, Afeefa, Aleesha Naheed, Zaima Latif, Sehar Nadeem, Natasha Mehmood e Mishal Arzoo. "Applications and Limitations of 3D Bioprinters in Tissue Culturing: A Review". Volume 5 Issue 1, Volume 5 Issue 1 (30 de junho de 2022): 31–43. http://dx.doi.org/10.34091/ajls.5.1.4.
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3D bioprinting is an advanced technology that uses different biomaterial like hydrogels and bio-inks to develop artificial tissue cells and organs. There are three types of bioprinting techniques: Jetting-based bioprinting, extrusion based bioprinting, and integrated bioprinting. Biomaterials used in 3D bioprinter should have some ideal characteristics such as they should be biocompatible, printable, and provide mechanical and structural properties. There are different types of bio-inks, hydrogels, and growth factors used to overcome the crisis of organ shortage. Bioprinting technology is essential for the development of eleven organ systems as there is a need for organ replacement and tissue regeneration. It is possible to make complex tissue culture structures by using 3D bioprinting. The mixture of biomaterial and living cells used for bioprinting is called bio-inks. Hydrogels are one of the ideal components of biomaterials as it has similar characteristics as natural extracellular matrix and provides a hydrated environment for cells to divide. Generation and transportation of many tissues, including skin, heart tissues, cartilaginous constructs, and tracheal tissues is done by 3D bioprinting. It is used for research purposes, drug testing, and drug discovery. But our focus is to highlight the applications of 3D bioprinters in tissue engineering and the development of organ systems. Skin tissues have also been engineered to overcome complex skin treatment procedures and to save time and cost. Keywords: 3D bioprinting; Bio-inks; Biomaterials; Hydrogels; Tissue Culturing
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Akram, Ambreen, Mujahid Iqbal, Aqeela Yasin, Kun Zhang e Jingan Li. "Sulfonated Molecules and Their Latest Applications in the Field of Biomaterials: A Review". Coatings 14, n.º 2 (19 de fevereiro de 2024): 243. http://dx.doi.org/10.3390/coatings14020243.
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This review provides an overview of the latest applications of sulfonated molecules in biomaterials. Sulfonation, a chemical modification process introducing sulfonic acid groups, enhances biomaterial properties. This review explores the effect of sulfonation and recent innovations in biomaterial applications. It covers hydrogels, scaffolds, and nanoparticles, emphasizing sulfonation’s unique advantages. The impact on cellular responses, including adhesion, proliferation, and differentiation, is discussed. This review also addresses sulfonated biomaterials’ role in regenerative medicine, drug delivery, and tissue engineering challenges. It also provides a small overview of the sources and features of marine-derived sulfonated molecules, emphasizing their potential roles in advancing scientific research. As a novel aspect, an unconventional complex, “traditional Chinese medicine” and its sulfonation method have come to the forefront after a thousand years of history. This article concludes with a reflection on current research and future avenues, highlighting sulfonation’s transformative potential in biomedicine.
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Chen, Manyu, Qiguang Wang, Yunbing Wang, Yujiang Fan e Xingdong Zhang. "Biomaterials-assisted exosomes therapy in osteoarthritis". Biomedical Materials 17, n.º 2 (2 de fevereiro de 2022): 022001. http://dx.doi.org/10.1088/1748-605x/ac4c8c.
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Abstract Due to the avascular characteristic of articular cartilage, its self-repair capacity is limited. When cartilage is damaged or forms osteoarthritis (OA), clinical treatment is necessary. However, conventional treatments, including joint replacement, microfracture, cell and drug therapies, have certain limits. Lately, the exosomes derived from mesenchymal stem cells (MSCs-EXO), which consist of complex transcription factors, proteins and targeting ligand components, have shown great therapeutic potentials. With recent advancements in various biomaterials to extend MSCs-EXO’s retention time and control the release properties in vivo, biomaterials-assisted exosomes therapy has been soon becoming a practically powerful tool in treating OA. This review analyzes the effects of MSCs-EXO on OA inflammation, metabolism, ageing and apoptosis, and introduces the combinational systems of MSCs-EXO with biomaterials to enhance the repair, anti-inflammatory, and homeostasis regulation functions. Moreover, different types of natural or synthetic biomaterials and their applications with MSCs-EXO were also described and discussed. And finally, we presage the future perspective in the development of biomaterial-assisted exosome therapies, as well as the potential to incorporate with other treatments to enhance their therapeutic effects in OA.
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Torrealba, Débora, Joaquin Seras-Franzoso, Uwe Mamat, Kathleen Wilke, Antonio Villaverde, Nerea Roher e Elena Garcia-Fruitós. "Complex Particulate Biomaterials as Immunostimulant-Delivery Platforms". PLOS ONE 11, n.º 10 (7 de outubro de 2016): e0164073. http://dx.doi.org/10.1371/journal.pone.0164073.
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Kretlow, James D., Simon Young, Leda Klouda, Mark Wong e Antonios G. Mikos. "Injectable Biomaterials for Regenerating Complex Craniofacial Tissues". Advanced Materials 21, n.º 32-33 (4 de setembro de 2009): 3368–93. http://dx.doi.org/10.1002/adma.200802009.
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Islam, Mohammad Ariful, Emma K. G. Reesor, Yingjie Xu, Harshal R. Zope, Bruce R. Zetter e Jinjun Shi. "Biomaterials for mRNA delivery". Biomaterials Science 3, n.º 12 (2015): 1519–33. http://dx.doi.org/10.1039/c5bm00198f.
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Schematic representation of various biomaterial-based systems for mRNA delivery: (a) protamine–mRNA complex; (b) lipid nanoparticle; (c) lipid nanoparticle with inorganic compounds (e.g.apatite); (d) cationic polymeric nanoparticle; (e) lipid–polymer hybrid nanoparticles including (i) mRNA–polymer complex core surrounded by a lipid shell and (ii) polymer core surrounded by a lipid shell with mRNA absorbed onto the surface; and (f) gold nanoparticle.
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Chan, Weng Wan, David Chen Loong Yeo, Vernice Tan, Satnam Singh, Deepak Choudhury e May Win Naing. "Additive Biomanufacturing with Collagen Inks". Bioengineering 7, n.º 3 (1 de julho de 2020): 66. http://dx.doi.org/10.3390/bioengineering7030066.
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Collagen is a natural polymer found abundantly in the extracellular matrix (ECM). It is easily extracted from a variety of sources and exhibits excellent biological properties such as biocompatibility and weak antigenicity. Additionally, different processes allow control of physical and chemical properties such as mechanical stiffness, viscosity and biodegradability. Moreover, various additive biomanufacturing technology has enabled layer-by-layer construction of complex structures to support biological function. Additive biomanufacturing has expanded the use of collagen biomaterial in various regenerative medicine and disease modelling application (e.g., skin, bone and cornea). Currently, regulatory hurdles in translating collagen biomaterials still remain. Additive biomanufacturing may help to overcome such hurdles commercializing collagen biomaterials and fulfill its potential for biomedicine.
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Khanna, Astha, Maedeh Zamani e Ngan F. Huang. "Extracellular Matrix-Based Biomaterials for Cardiovascular Tissue Engineering". Journal of Cardiovascular Development and Disease 8, n.º 11 (22 de outubro de 2021): 137. http://dx.doi.org/10.3390/jcdd8110137.
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Regenerative medicine and tissue engineering strategies have made remarkable progress in remodeling, replacing, and regenerating damaged cardiovascular tissues. The design of three-dimensional (3D) scaffolds with appropriate biochemical and mechanical characteristics is critical for engineering tissue-engineered replacements. The extracellular matrix (ECM) is a dynamic scaffolding structure characterized by tissue-specific biochemical, biophysical, and mechanical properties that modulates cellular behavior and activates highly regulated signaling pathways. In light of technological advancements, biomaterial-based scaffolds have been developed that better mimic physiological ECM properties, provide signaling cues that modulate cellular behavior, and form functional tissues and organs. In this review, we summarize the in vitro, pre-clinical, and clinical research models that have been employed in the design of ECM-based biomaterials for cardiovascular regenerative medicine. We highlight the research advancements in the incorporation of ECM components into biomaterial-based scaffolds, the engineering of increasingly complex structures using biofabrication and spatial patterning techniques, the regulation of ECMs on vascular differentiation and function, and the translation of ECM-based scaffolds for vascular graft applications. Finally, we discuss the challenges, future perspectives, and directions in the design of next-generation ECM-based biomaterials for cardiovascular tissue engineering and clinical translation.
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Levin, Alexandra, Vaibhav Sharma, Lilian Hook e Elena García-Gareta. "The importance of factorial design in tissue engineering and biomaterials science: Optimisation of cell seeding efficiency on dermal scaffolds as a case study". Journal of Tissue Engineering 9 (1 de janeiro de 2018): 204173141878169. http://dx.doi.org/10.1177/2041731418781696.
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This article presents a case study to show the usefulness and importance of using factorial design in tissue engineering and biomaterials science. We used a full factorial experimental design (2 × 2 × 2 × 3) to solve a routine query in every biomaterial research project: the optimisation of cell seeding efficiency for pre-clinical in vitro cell studies, the importance of which is often overlooked. In addition, tissue-engineered scaffolds can be cellularised with relevant cell type(s) to form implantable tissue constructs, where the cell seeding method must be reliable and robust. Our results show the complex relationship between cells and scaffolds and suggest that the optimum seeding conditions for each material may be different due to different material properties, and therefore, should be investigated for individual scaffolds. Our factorial experimental design can be easily translated to other cell types and three-dimensional biomaterials, where multiple interacting variables can be thoroughly investigated for better understanding of cell–biomaterial interactions.
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Chew, Sue Anne, Stefania Moscato, Sachin George, Bahareh Azimi e Serena Danti. "Liver Cancer: Current and Future Trends Using Biomaterials". Cancers 11, n.º 12 (16 de dezembro de 2019): 2026. http://dx.doi.org/10.3390/cancers11122026.
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Hepatocellular carcinoma (HCC) is the fifth most common type of cancer diagnosed and the second leading cause of death worldwide. Despite advancement in current treatments for HCC, the prognosis for this cancer is still unfavorable. This comprehensive review article focuses on all the current technology that applies biomaterials to treat and study liver cancer, thus showing the versatility of biomaterials to be used as smart tools in this complex pathologic scenario. Specifically, after introducing the liver anatomy and pathology by focusing on the available treatments for HCC, this review summarizes the current biomaterial-based approaches for systemic delivery and implantable tools for locally administrating bioactive factors and provides a comprehensive discussion of the specific therapies and targeting agents to efficiently deliver those factors. This review also highlights the novel application of biomaterials to study HCC, which includes hydrogels and scaffolds to tissue engineer 3D in vitro models representative of the tumor environment. Such models will serve to better understand the tumor biology and investigate new therapies for HCC. Special focus is given to innovative approaches, e.g., combined delivery therapies, and to alternative approaches—e.g., cell capture—as promising future trends in the application of biomaterials to treat HCC.
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Al-Maawi, Sarah, Carlos Herrera-Vizcaíno, Anna Orlowska, Ines Willershausen, Robert Sader, Richard J. Miron, Joseph Choukroun e Shahram Ghanaati. "Biologization of Collagen-Based Biomaterials Using Liquid-Platelet-Rich Fibrin: New Insights into Clinically Applicable Tissue Engineering". Materials 12, n.º 23 (2 de dezembro de 2019): 3993. http://dx.doi.org/10.3390/ma12233993.
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Platelet-rich fibrin (PRF) is a blood concentrate derived from venous blood that is processed without anticoagulants by a one-step centrifugation process. This three-dimensional scaffold contains inflammatory cells and plasma proteins entrapped in a fibrin matrix. Liquid-PRF was developed based on the previously described low-speed centrifuge concept (LSCC), which allowed the introduction of a liquid-PRF formulation of fibrinogen and thrombin prior to its conversion to fibrin. Liquid-PRF was introduced to meet the clinical demand for combination with biomaterials in a clinically applicable and easy-to-use way. The aim of the present study was to evaluate, ex vivo, the interaction of the liquid-PRF constituents with five different collagen biomaterials by histological analyses. The results first demonstrated that large variability existed between the biomaterials investigated. Liquid-PRF was able to completely invade Mucograft® (MG; Geistlich Biomaterials, Wolhusen, Switzerland) and to partly invade Bio-Gide® (BG; Geistlich Biomaterials, Wolhusen, Switzerland) and Mucoderm® (MD; Botiss Biomaterials, Berlin, Germany), and Collprotect® (CP; Botiss Biomaterials, Berlin, Germany) showed only a superficial interaction. The BEGO® collagen membrane (BCM; BEGO Implant Systems) appeared to be completely free of liquid-PRF. These results were confirmed by the different cellular penetration and liquid-PRF absorption coefficient (PAC) values of the evaluated membranes. The present study demonstrates a system for loading biomaterials with a complex autologous cell system (liquid-PRF) in a relatively short period of time and in a clinically relevant manner. The combination of biomaterials with liquid-PRF may be clinically utilized to enhance the bioactivity of collagen-based biomaterials and may act as a biomaterial-based growth factor delivery system.
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Candelari, Mara, Ida Anna Cappello, Luigi Pannone, Cinzia Monaco, Edoardo Bori, Giacomo Talevi, Robbert Ramak et al. "3D-Printed Biomaterial Testing in Response to Cryoablation: Implications for Surgical Ventricular Tachycardia Ablation". Journal of Clinical Medicine 12, n.º 3 (29 de janeiro de 2023): 1036. http://dx.doi.org/10.3390/jcm12031036.
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Background: The lack of thermally and mechanically performant biomaterials represents the major limit for 3D-printed surgical guides, aimed at facilitating complex surgery and ablations. Methods: Cryosurgery is a treatment for cardiac arrhythmias. It consists of obtaining cryolesions, by freezing the target tissue, resulting in selective and irreversible damage. MED625FLX and TPU95A are two biocompatible materials for surgical guides; however, there are no data on their response to cryoenergy delivery. The study purpose is to evaluate the biomaterials’ thermal properties, examining the temperature changes on the porcine muscle samples (PMS) when the biomaterials are in place during the cryoablation. Two biomaterials were selected, MED625FLX and TPU95A, with two thicknesses (1.0 and 2.5 mm). To analyze the biomaterials’ behavior, the PMS temperatures were measured during cryoablation, firstly without biomaterials (control) and after with the biomaterials in place. To verify the biomaterials’ suitability, the temperatures under the biomaterial samples should not exceed a limit of −30.0 °C. Furthermore, the biomaterials’ geometry after cryoablation was evaluated using the grid paper test. Results: TPU95A (1.0 and 2.5 mm) successfully passed all tests, making this material suitable for cryoablation treatment. MED625FLX of 1.0 mm did not retain its shape, losing its function according to the grid paper test. Further, MED625FLX of 2.5 mm is also suitable for use with a cryoenergy source. Conclusions: TPU95A (1.0 and 2.5 mm) and MED625FLX of 2.5 mm could be used in the design of surgical guides for cryoablation treatment, because of their mechanical, geometrical, and thermal properties. The positive results from the thermal tests on these materials and their thickness prompt further clinical investigation.
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Ødegaard, Kristin S., Jan Torgersen e Christer W. Elverum. "Structural and Biomedical Properties of Common Additively Manufactured Biomaterials: A Concise Review". Metals 10, n.º 12 (15 de dezembro de 2020): 1677. http://dx.doi.org/10.3390/met10121677.
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Biomaterials are in high demand due to the increasing geriatric population and a high prevalence of cardiovascular and orthopedic disorders. The combination of additive manufacturing (AM) and biomaterials is promising, especially towards patient-specific applications. With AM, unique and complex structures can be manufactured. Furthermore, the direct link to computer-aided design and digital scans allows for a direct replicable product. However, the appropriate selection of biomaterials and corresponding AM methods can be challenging but is a key factor for success. This article provides a concise material selection guide for the AM biomedical field. After providing a general description of biomaterial classes—biotolerant, bioinert, bioactive, and biodegradable—we give an overview of common ceramic, polymeric, and metallic biomaterials that can be produced by AM and review their biomedical and mechanical properties. As the field of load-bearing metallic implants experiences rapid growth, we dedicate a large portion of this review to this field and portray interesting future research directions. This article provides a general overview of the field, but it also provides possibilities for deepening the knowledge in specific aspects as it comprises comprehensive tables including materials, applications, AM techniques, and references.
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Kesti, Matti, Christian Eberhardt, Guglielmo Pagliccia, David Kenkel, Daniel Grande, Andreas Boss e Marcy Zenobi-Wong. "Bioprinting Complex Cartilaginous Structures with Clinically Compliant Biomaterials". Advanced Functional Materials 25, n.º 48 (19 de novembro de 2015): 7406–17. http://dx.doi.org/10.1002/adfm.201503423.
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Tatara, Alexander M., Gerry L. Koons, Emma Watson, Trenton C. Piepergerdes, Sarita R. Shah, Brandon T. Smith, Jonathan Shum et al. "Biomaterials-aided mandibular reconstruction using in vivo bioreactors". Proceedings of the National Academy of Sciences 116, n.º 14 (18 de março de 2019): 6954–63. http://dx.doi.org/10.1073/pnas.1819246116.
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Large mandibular defects are clinically challenging to reconstruct due to the complex anatomy of the jaw and the limited availability of appropriate tissue for repair. We envision leveraging current advances in fabrication and biomaterials to create implantable devices that generate bone within the patients themselves suitable for their own specific anatomical pathology. The in vivo bioreactor strategy facilitates the generation of large autologous vascularized bony tissue of customized geometry without the addition of exogenous growth factors or cells. To translate this technology, we investigated its success in reconstructing a mandibular defect of physiologically relevant size in sheep. We fabricated and implanted 3D-printed in vivo bioreactors against rib periosteum and utilized biomaterial-based space maintenance to preserve the native anatomical mandibular structure in the defect site before reconstruction. Nine weeks after bioreactor implantation, the ovine mandibles were repaired with the autologous bony tissue generated from the in vivo bioreactors. We evaluated tissues generated in bioreactors by radiographic, histological, mechanical, and biomolecular assays and repaired mandibles by radiographic and histological assays. Biomaterial-aided mandibular reconstruction was successful in a large superior marginal defect in five of six (83%) sheep. Given that these studies utilized clinically available biomaterials, such as bone cement and ceramic particles, this strategy is designed for rapid human translation to improve outcomes in patients with large mandibular defects.
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Filip, Diana Georgiana, Vasile-Adrian Surdu, Andrei Viorel Paduraru e Ecaterina Andronescu. "Current Development in Biomaterials—Hydroxyapatite and Bioglass for Applications in Biomedical Field: A Review". Journal of Functional Biomaterials 13, n.º 4 (16 de novembro de 2022): 248. http://dx.doi.org/10.3390/jfb13040248.
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Inorganic biomaterials, including different types of metals and ceramics are widely used in various fields due to their biocompatibility, bioactivity, and bioresorbable capacity. In recent years, biomaterials have been used in biomedical and biological applications. Calcium phosphate (CaPs) compounds are gaining importance in the field of biomaterials used as a standalone material or in more complex structures, especially for bone substitutes and drug delivery systems. The use of multiple dopants into the structure of CaPs compounds can significantly improve their in vivo and in vitro activity. Among the general information included in the Introduction section, in the first section of this review paper, the authors provided a background on the development of hydroxyapatite, methods of synthesis, and its applications. The advantages of using different ions and co-ions for substitution into the hydroxyapatite lattice and their influence on physicochemical, antibacterial, and biological properties of hydroxyapatite are also presented in this section of the review paper. Larry Hench’s 45S5 Bioglass®, commercially named 45S5, was the first bioactive glass that revealed a chemical bond with bone, highlighting the potential of this biomaterial to be widely used in biomedicine for bone regeneration. The second section of this article is focused on the development and current products based on 45S5 Bioglass®, covering the historical evolution, importance of the sintering method, hybrid bioglass composites, and applications. To overcome the limitations of the original biomaterials, studies were performed to combine hydroxyapatite and 45S5 Bioglass® into new composites used for their high bioactivity and improved properties. This particular type of combined hydroxyapatite/bioglass biomaterial is discussed in the last section of this review paper.
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Chakraborty, Arnab, Fabien Deligey, Jenny Quach, Frederic Mentink-Vigier, Ping Wang e Tuo Wang. "Biomolecular complex viewed by dynamic nuclear polarization solid-state NMR spectroscopy". Biochemical Society Transactions 48, n.º 3 (7 de maio de 2020): 1089–99. http://dx.doi.org/10.1042/bst20191084.
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Solid-state nuclear magnetic resonance (ssNMR) is an indispensable tool for elucidating the structure and dynamics of insoluble and non-crystalline biomolecules. The recent advances in the sensitivity-enhancing technique magic-angle spinning dynamic nuclear polarization (MAS-DNP) have substantially expanded the territory of ssNMR investigations and enabled the detection of polymer interfaces in a cellular environment. This article highlights the emerging MAS-DNP approaches and their applications to the analysis of biomolecular composites and intact cells to determine the folding pathway and ligand binding of proteins, the structural polymorphism of low-populated biopolymers, as well as the physical interactions between carbohydrates, proteins, and lignin. These structural features provide an atomic-level understanding of many cellular processes, promoting the development of better biomaterials and inhibitors. It is anticipated that the capabilities of MAS-DNP in biomolecular and biomaterial research will be further enlarged by the rapid development of instrumentation and methodology.
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Shick, Tang Mei, Aini Zuhra Abdul Kadir, Nor Hasrul Akhmal Ngadiman e Azanizawati Ma’aram. "A review of biomaterials scaffold fabrication in additive manufacturing for tissue engineering". Journal of Bioactive and Compatible Polymers 34, n.º 6 (25 de setembro de 2019): 415–35. http://dx.doi.org/10.1177/0883911519877426.
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The current developments in three-dimensional printing also referred as “additive manufacturing” have transformed the scenarios for modern manufacturing and engineering design processes which show greatest advantages for the fabrication of complex structures such as scaffold for tissue engineering. This review aims to introduce additive manufacturing techniques in tissue engineering, types of biomaterials used in scaffold fabrication, as well as in vitro and in vivo evaluations. Biomaterials and fabrication methods could critically affect the outcomes of scaffold mechanical properties, design architectures, and cell proliferations. In addition, an ideal scaffold aids the efficiency of cell proliferation and allows the movements of cell nutrient inside the human body with their specific material properties. This article provides comprehensive review that covers broad range of all the biomaterial types using various additive manufacturing technologies. The data were extracted from 2008 to 2018 mostly from Google Scholar, ScienceDirect, and Scopus using keywords such as “Additive Manufacturing,” “3D Printing,” “Tissue Engineering,” “Biomaterial” and “Scaffold.” A 10 years research in this area was found to be mostly focused toward obtaining an ideal scaffold by investigating the fabrication strategies, biomaterials compatibility, scaffold design effectiveness through computer-aided design modeling, and optimum printing machine parameters identification. As a conclusion, this ideal scaffold fabrication can be obtained with the combination of different materials that could enhance the material properties which performed well in optimum additive manufacturing condition. Yet, there are still many challenges from the printing methods, bioprinting and cell culturing that needs to be discovered and investigated in the future.
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Cao, Uyen M. N., Yuli Zhang, Julie Chen, Darren Sayson, Sangeeth Pillai e Simon D. Tran. "Microfluidic Organ-On-A-Chip: A Guide to Biomaterial Choice and Fabrication". International Journal of Molecular Sciences 24, n.º 4 (6 de fevereiro de 2023): 3232. http://dx.doi.org/10.3390/ijms24043232.
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Organ-on-a-chip (OoAC) devices are miniaturized, functional, in vitro constructs that aim to recapitulate the in vivo physiology of an organ using different cell types and extracellular matrix, while maintaining the chemical and mechanical properties of the surrounding microenvironments. From an end-point perspective, the success of a microfluidic OoAC relies mainly on the type of biomaterial and the fabrication strategy employed. Certain biomaterials, such as PDMS (polydimethylsiloxane), are preferred over others due to their ease of fabrication and proven success in modelling complex organ systems. However, the inherent nature of human microtissues to respond differently to surrounding stimulations has led to the combination of biomaterials ranging from simple PDMS chips to 3D-printed polymers coated with natural and synthetic materials, including hydrogels. In addition, recent advances in 3D printing and bioprinting techniques have led to the powerful combination of utilizing these materials to develop microfluidic OoAC devices. In this narrative review, we evaluate the different materials used to fabricate microfluidic OoAC devices while outlining their pros and cons in different organ systems. A note on combining the advances made in additive manufacturing (AM) techniques for the microfabrication of these complex systems is also discussed.
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Palomino-Durand, Carla, Emmanuel Pauthe e Adeline Gand. "Fibronectin-Enriched Biomaterials, Biofunctionalization, and Proactivity: A Review". Applied Sciences 11, n.º 24 (19 de dezembro de 2021): 12111. http://dx.doi.org/10.3390/app112412111.
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Modern innovation in reconstructive medicine implies the proposition of material-based strategies suitable for tissue repair and regeneration. The development of such systems necessitates the design of advanced materials and the control of their interactions with their surrounding cellular and molecular microenvironments. Biomaterials must actively engage cellular matter to direct and modulate biological responses at implant sites and beyond. Indeed, it is essential that a true dialogue exists between the implanted device and the cells. Biomaterial engineering implies the knowledge and control of cell fate considering the globality of the adhesion process, from initial cell attachment to differentiation. The extracellular matrix (ECM) represents a complex microenvironment able to meet these essential needs to establish a relationship between the material and the contacting cells. The ECM exhibits specific physical, chemical, and biochemical characteristics. Considering the complexity, heterogeneity, and versatility of ECM actors, fibronectin (Fn) has emerged among the ECM protagonists as the most pertinent representative key actor. The following review focuses on and synthesizes the research supporting the potential to use Fn in biomaterial functionalization to mimic the ECM and enhance cell–material interactions.
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Liu, Siyu, Tianlin Wang, Shenglong Li e Xiaohong Wang. "Application Status of Sacrificial Biomaterials in 3D Bioprinting". Polymers 14, n.º 11 (27 de maio de 2022): 2182. http://dx.doi.org/10.3390/polym14112182.
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Additive manufacturing, also known as three-dimensional (3D) printing, relates to several rapid prototyping (RP) technologies, and has shown great potential in the manufacture of organoids and even complex bioartificial organs. A major challenge for 3D bioprinting complex org unit ans is the competitive requirements with respect to structural biomimeticability, material integrability, and functional manufacturability. Over the past several years, 3D bioprinting based on sacrificial templates has shown its unique advantages in building hierarchical vascular networks in complex organs. Sacrificial biomaterials as supporting structures have been used widely in the construction of tubular tissues. The advent of suspension printing has enabled the precise printing of some soft biomaterials (e.g., collagen and fibrinogen), which were previously considered unprintable singly with cells. In addition, the introduction of sacrificial biomaterials can improve the porosity of biomaterials, making the printed structures more favorable for cell proliferation, migration and connection. In this review, we mainly consider the latest developments and applications of 3D bioprinting based on the strategy of sacrificial biomaterials, discuss the basic principles of sacrificial templates, and look forward to the broad prospects of this approach for complex organ engineering or manufacturing.
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Varghese, Jothi, Anjale Rajagopal e Shashikiran Shanmugasundaram. "Role of Biomaterials Used for Periodontal Tissue Regeneration—A Concise Evidence-Based Review". Polymers 14, n.º 15 (27 de julho de 2022): 3038. http://dx.doi.org/10.3390/polym14153038.
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Periodontal infections are noncommunicable chronic inflammatory diseases of multifactorial origin that can induce destruction of both soft and hard tissues of the periodontium. The standard remedial modalities for periodontal regeneration include nonsurgical followed by surgical therapy with the adjunctive use of various biomaterials to achieve restoration of the lost tissues. Lately, there has been substantial development in the field of biomaterial, which includes the sole or combined use of osseous grafts, barrier membranes, growth factors and autogenic substitutes to achieve tissue and bone regeneration. Of these, bone replacement grafts have been widely explored for their osteogenic potential with varied outcomes. Osseous grafts are derived from either human, bovine or synthetic sources. Though the biologic response from autogenic biomaterials may be better, the use of bone replacement synthetic substitutes could be practical for clinical practice. This comprehensive review focuses initially on bone graft replacement substitutes, namely ceramic-based (calcium phosphate derivatives, bioactive glass) and autologous platelet concentrates, which assist in alveolar bone regeneration. Further literature compilations emphasize the innovations of biomaterials used as bone substitutes, barrier membranes and complex scaffold fabrication techniques that can mimic the histologically vital tissues required for the regeneration of periodontal apparatus.
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Dorogin, Jonathan, Jakob M. Townsend e Marian H. Hettiaratchi. "Biomaterials for protein delivery for complex tissue healing responses". Biomaterials Science 9, n.º 7 (2021): 2339–61. http://dx.doi.org/10.1039/d0bm01804j.
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Ilyas, R. A., M. Y. M. Zuhri, Mohd Nor Faiz Norrrahim, Muhammad Syukri Mohamad Misenan, Mohd Azwan Jenol, Sani Amril Samsudin, N. M. Nurazzi et al. "Natural Fiber-Reinforced Polycaprolactone Green and Hybrid Biocomposites for Various Advanced Applications". Polymers 14, n.º 1 (3 de janeiro de 2022): 182. http://dx.doi.org/10.3390/polym14010182.
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Recent developments within the topic of biomaterials has taken hold of researchers due to the mounting concern of current environmental pollution as well as scarcity resources. Amongst all compatible biomaterials, polycaprolactone (PCL) is deemed to be a great potential biomaterial, especially to the tissue engineering sector, due to its advantages, including its biocompatibility and low bioactivity exhibition. The commercialization of PCL is deemed as infant technology despite of all its advantages. This contributed to the disadvantages of PCL, including expensive, toxic, and complex. Therefore, the shift towards the utilization of PCL as an alternative biomaterial in the development of biocomposites has been exponentially increased in recent years. PCL-based biocomposites are unique and versatile technology equipped with several importance features. In addition, the understanding on the properties of PCL and its blend is vital as it is influenced by the application of biocomposites. The superior characteristics of PCL-based green and hybrid biocomposites has expanded their applications, such as in the biomedical field, as well as in tissue engineering and medical implants. Thus, this review is aimed to critically discuss the characteristics of PCL-based biocomposites, which cover each mechanical and thermal properties and their importance towards several applications. The emergence of nanomaterials as reinforcement agent in PCL-based biocomposites was also a tackled issue within this review. On the whole, recent developments of PCL as a potential biomaterial in recent applications is reviewed.
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Da Silva, Jessica, Ermelindo C. Leal, Eugénia Carvalho e Eduardo A. Silva. "Innovative Functional Biomaterials as Therapeutic Wound Dressings for Chronic Diabetic Foot Ulcers". International Journal of Molecular Sciences 24, n.º 12 (8 de junho de 2023): 9900. http://dx.doi.org/10.3390/ijms24129900.
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The imbalance of local and systemic factors in individuals with diabetes mellitus (DM) delays, or even interrupts, the highly complex and dynamic process of wound healing, leading to diabetic foot ulceration (DFU) in 15 to 25% of cases. DFU is the leading cause of non-traumatic amputations worldwide, posing a huge threat to the well-being of individuals with DM and the healthcare system. Moreover, despite all the latest efforts, the efficient management of DFUs still remains a clinical challenge, with limited success rates in treating severe infections. Biomaterial-based wound dressings have emerged as a therapeutic strategy with rising potential to handle the tricky macro and micro wound environments of individuals with DM. Indeed, biomaterials have long been related to unique versatility, biocompatibility, biodegradability, hydrophilicity, and wound healing properties, features that make them ideal candidates for therapeutic applications. Furthermore, biomaterials may be used as a local depot of biomolecules with anti-inflammatory, pro-angiogenic, and antimicrobial properties, further promoting adequate wound healing. Accordingly, this review aims to unravel the multiple functional properties of biomaterials as promising wound dressings for chronic wound healing, and to examine how these are currently being evaluated in research and clinical settings as cutting-edge wound dressings for DFU management.
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Kaushik, Neha, Linh Nhat Nguyen, June Hyun Kim, Eun Ha Choi e Nagendra Kumar Kaushik. "Strategies for Using Polydopamine to Induce Biomineralization of Hydroxyapatite on Implant Materials for Bone Tissue Engineering". International Journal of Molecular Sciences 21, n.º 18 (7 de setembro de 2020): 6544. http://dx.doi.org/10.3390/ijms21186544.
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In the field of tissue engineering, there are several issues to consider when designing biomaterials for implants, including cellular interaction, good biocompatibility, and biochemical activity. Biomimetic mineralization has gained considerable attention as an emerging approach for the synthesis of biocompatible materials with complex shapes, categorized organization, controlled shape, and size in aqueous environments. Understanding biomineralization strategies could enhance opportunities for novel biomimetic mineralization approaches. In this regard, mussel-inspired biomaterials have recently attracted many researchers due to appealing features, such as strong adhesive properties on moist surfaces, improved cell adhesion, and immobilization of bioactive molecules via catechol chemistry. This molecular designed approach has been a key point in combining new functionalities into accessible biomaterials for biomedical applications. Polydopamine (PDA) has emerged as a promising material for biomaterial functionalization, considering its simple molecular structure, independence of target materials, cell interactions for adhesion, and robust reactivity for resulting functionalization. In this review, we highlight the strategies for using PDA to induce the biomineralization of hydroxyapatite (HA) on the surface of various implant materials with good mechanical strength and corrosion resistance. We also discuss the interactions between the PDA-HA coating, and several cell types that are intricate in many biomedical applications, involving bone defect repair, bone regeneration, cell attachment, and antibacterial activity.
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da Silva, Victor A., Bianca C. Bobotis, Felipe F. Correia, Théo H. Lima-Vasconcellos, Gabrielly M. D. Chiarantin, Laura De La Vega, Christiane B. Lombello et al. "The Impact of Biomaterial Surface Properties on Engineering Neural Tissue for Spinal Cord Regeneration". International Journal of Molecular Sciences 24, n.º 17 (4 de setembro de 2023): 13642. http://dx.doi.org/10.3390/ijms241713642.
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Tissue engineering for spinal cord injury (SCI) remains a complex and challenging task. Biomaterial scaffolds have been suggested as a potential solution for supporting cell survival and differentiation at the injury site. However, different biomaterials display multiple properties that significantly impact neural tissue at a cellular level. Here, we evaluated the behavior of different cell lines seeded on chitosan (CHI), poly (ε-caprolactone) (PCL), and poly (L-lactic acid) (PLLA) scaffolds. We demonstrated that the surface properties of a material play a crucial role in cell morphology and differentiation. While the direct contact of a polymer with the cells did not cause cytotoxicity or inhibit the spread of neural progenitor cells derived from neurospheres (NPCdn), neonatal rat spinal cord cells (SCC) and NPCdn only attached and matured on PCL and PLLA surfaces. Scanning electron microscopy and computational analysis suggested that cells attached to the material’s surface emerged into distinct morphological populations. Flow cytometry revealed a higher differentiation of neural progenitor cells derived from human induced pluripotent stem cells (hiPSC-NPC) into glial cells on all biomaterials. Immunofluorescence assays demonstrated that PCL and PLLA guided neuronal differentiation and network development in SCC. Our data emphasize the importance of selecting appropriate biomaterials for tissue engineering in SCI treatment.
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Sarmin, Atiya M., Nadia El Moussaid, Ratima Suntornnond, Eleanor J. Tyler, Yang-Hee Kim, Stefania Di Cio, William V. Megone et al. "Multi-Scale Analysis of the Composition, Structure, and Function of Decellularized Extracellular Matrix for Human Skin and Wound Healing Models". Biomolecules 12, n.º 6 (16 de junho de 2022): 837. http://dx.doi.org/10.3390/biom12060837.
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The extracellular matrix (ECM) is a complex mixture of structural proteins, proteoglycans, and signaling molecules that are essential for tissue integrity and homeostasis. While a number of recent studies have explored the use of decellularized ECM (dECM) as a biomaterial for tissue engineering, the complete composition, structure, and mechanics of these materials remain incompletely understood. In this study, we performed an in-depth characterization of skin-derived dECM biomaterials for human skin equivalent (HSE) models. The dECM materials were purified from porcine skin, and through mass spectrometry profiling, we quantified the presence of major ECM molecules, including types I, III, and VI collagen, fibrillin, and lumican. Rheological analysis demonstrated the sol-gel and shear-thinning properties of dECM materials, indicating their physical suitability as a tissue scaffold, while electron microscopy revealed a complex, hierarchical structure of nanofibers in dECM hydrogels. The dECM materials were compatible with advanced biofabrication techniques, including 3D printing within a gelatin microparticle support bath, printing with a sacrificial material, or blending with other ECM molecules to achieve more complex compositions and structures. As a proof of concept, we also demonstrate how dECM materials can be fabricated into a 3D skin wound healing model using 3D printing. Skin-derived dECM therefore represents a complex and versatile biomaterial with advantageous properties for the fabrication of next-generation HSEs.
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Ren, Xiang, Qingwei Zhang, Kewei Liu, Ho-lung Li e Jack G. Zhou. "Modeling of pneumatic valve dispenser for printing viscous biomaterials in additive manufacturing". Rapid Prototyping Journal 20, n.º 6 (20 de outubro de 2014): 434–43. http://dx.doi.org/10.1108/rpj-03-2013-0025.
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Purpose – The purpose of this paper is establishing a general mathematical model and theoretical design rules for 3D printing of biomaterials. Additive manufacturing of biomaterials provides many opportunities for fabrication of complex tissue structures, which are difficult to fabricate by traditional manufacturing methods. Related problems and research tasks are raised by the study on biomaterials’ 3D printing. Most researchers are interested in the materials studies; however, the corresponded additive manufacturing machine is facing some technical problems in printing user-prepared biomaterials. New biomaterials have uncertainty in physical properties, such as viscosity and surface tension coefficient. Therefore, the 3D printing process requires lots of trials to achieve proper printing parameters, such as printing layer thickness, maximum printing line distance and printing nozzle’s feeding speed; otherwise, the desired computer-aided design (CAD) file will not be printed successfully in 3D printing. Design/methodology/approach – Most additive manufacturing machine for user-prepared bio-material use pneumatic valve dispensers or extruder as printing nozzle, because the air pressure activated valve can print many different materials, which have a wide range of viscosity. We studied the structure inside the pneumatic valve dispenser in our 3D heterogeneous printing machine, and established mathematical models for 3D printing CAD structure and fluid behaviors inside the dispenser during printing process. Findings – Based on theoretical modeling, we found that the bio-material’s viscosity, surface tension coefficient and pneumatic valve dispenser’s dispensing step time will affect the final structure directly. We verified our mathematical model by printing of two kinds of self-prepared biomaterials, and the results supported our modeling and theoretical calculation. Research limitations/implications – For a certain kinds of biomaterials, the mathematical model and design rules will have unique solutions to the functions and equations. Therefore, each biomaterial’s physical data should be collected and input to the model for specified solutions. However, for each user-made 3D printing machine, the core programming code can be modified to adjust the parameters, which follows our mathematical model and the related CAD design rules. Originality – This study will provide a universal mathematical method to set up design rules for new user-prepared biomaterials in 3D printing of a CAD structure.
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Hong, Jaan, Joakim Andersson, Kristina Nilsson Ekdahl, Graciela Elgue, Niklas Axén, Rolf Larsson e Bo Nilsson. "Titanium Is a Highly Thrombogenic Biomaterial: Possible Implications for Osteogenesis". Thrombosis and Haemostasis 82, n.º 07 (1999): 58–64. http://dx.doi.org/10.1055/s-0037-1614630.
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SummaryTitanium has superior osteointegrating properties compared to other biomaterials. The mechanism for this is unknown. During the initial phase of bone implantation the biomaterial comes into direct contact with whole blood. In this study we use a newly developed in vitro chamber model to compare different commonly used biomaterials in contact with whole blood. These materials were selected with respect to their different osteointegrating properties in order to correlate these properties with the response to whole blood. In the presence of 3 IU/ml of heparin only titanium induced macroscopic clotting. This was reflected by the generation of thrombin-antithrombin which was much increased in blood in contact with titanium compared with steel and PVC. The coagulation activation caused by titanium was triggered by the intrinsic pathway because the generation of FXIIa-AT/C1 esterase inhibitor paralleled that of thrombin-antithrombin, and both thrombinantithrombin complex and FXIIa-AT/C1 esterase inhibitor generation were abrogated by corn trypsin inhibitor, which is a specific inhibitor of FXIIa. The binding of platelets was increased on the titanium surface compared to the other biomaterial surfaces and the state of platelet activation was much more pronounced as reflected by the levels of β-thromboglobulin and PDGF. This study indicates that titanium is unsuitable as a biomaterial in devices which are in direct contact with blood for a prolonged period. Furthermore, PDGF and other α-granule proteins e.g. TGF-β, are known to be potent promotors of osteogenesis which suggests that the pronounced thrombogenic properties of titanium might contribute to the good osteointegrating properties.
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Richard, Caroline. "Innovative Surface Treatments of Titanium Alloys for Biomedical Applications". Materials Science Forum 879 (novembro de 2016): 1570–75. http://dx.doi.org/10.4028/www.scientific.net/msf.879.1570.
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Biomedical engineering is an advanced technology based on an extremely complex development of advanced biomaterials. Since the first Consensus Conference in Chester (UK) on Definitions in Biomaterials of the European Society for Biomaterials, in 1986, biomaterial was defined as ‘a bioinert or bioactive material used in a material advice, intended to interact with biological systems, restore functions of natural living tissues and organism in the body’. In this way, passive metallic materials (as titanium alloys), a broad spectrum of bioceramics, even biopolymers and all combinations of these biomaterials are used for numerous medical devices owing to their high biocompatibility. For example, titanium alloys can be employed for the femoral stems in the total hip joint replacement (trh) or for dental applications. Among the different clinical aims of an implant, a high osseointegration is required and crucial. In order to prevent the alloys from the aggressive body environment, surface modification of implants are employed to render them protection from both wear, corrosion and even tribocorrosion. In addition to the surface treatments, new implant materials are also being fabricated with biocompatible alloying elements to reduce the toxic effects of the alloying elements. These presentation describes the methodologies that could be adapted to overcome some of the factors leading to implant failure. It gives a panorama and shows that the different processes can increase noticeably the performance of the alloy as orthopedic and dental implant. It also gives prospects for the development of new possible ways for enhancing the biosecurity of such material.
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Li, Wei, Qing Li, Jeffery Loughran, Michael Swain, Ionut Ichim e Naoki Fujisawa. "Contact-Driven Crack Formation in Dental Ceramic Materials". Key Engineering Materials 324-325 (novembro de 2006): 1257–60. http://dx.doi.org/10.4028/www.scientific.net/kem.324-325.1257.
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Natural human tooth consists of multiple layered quasi-brittle biomaterials, which make dental restorations experience a complex stress state under masticatory contact loading. As such, many restorations are prone to failure and a constant effort is made to improve the mechanical characteristics of the restorative materials. Clinical observations have shown that improved strengths and fracture toughness in ceramic materials do not necessarily lead to an anticipated higher functional longevity of the restoration. While substantial experimental investigations have been carried out to identify the contact induced fracture in such multi-layer material systems, numerical modelling of this event was largely unexplored. This paper presents a new numerical method to account for micro-damage driven fracture in various multi-layered biomaterial structures. In this study, a Rankine constitutive model is adopted and the crack initiation and propagation are automatically implemented in an explicit finite element (FE) framework. The effects of indenter radius, surface curvature and thickness of layered biomaterials on the cracking patterns are investigated. The results show good agreement with the experimental studies in literature.
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James, Bryan D., Paxton Guerin, Zion Iverson e Josephine B. Allen. "Mineralized DNA-collagen complex-based biomaterials for bone tissue engineering". International Journal of Biological Macromolecules 161 (outubro de 2020): 1127–39. http://dx.doi.org/10.1016/j.ijbiomac.2020.06.126.
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Armiento, Angela Rita, Luan Phelipe Hatt, Guillermo Sanchez Rosenberg, Keith Thompson e Martin James Stoddart. "Functional Biomaterials for Bone Regeneration: A Lesson in Complex Biology". Advanced Functional Materials 30, n.º 44 (19 de fevereiro de 2020): 1909874. http://dx.doi.org/10.1002/adfm.201909874.
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