Bibliografias temáticas / Circadian systems

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Literatura científica selecionada sobre o tema "Circadian systems"

Autor: Grafiati

Publicado: 5 de abril de 2025

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Artigos de revistas sobre o assunto "Circadian systems"

Roenneberg, Till, e Martha Merrow. "Circadian systems: different levels of complexity". Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences 356, n.º 1415 (29 de novembro de 2001): 1687–96. http://dx.doi.org/10.1098/rstb.2001.0969.

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After approximately 50 years of circadian research, especially in selected circadian model systems ( Drosophila, Neurospora, Gonyaulax and, more recently, cyanobacteria and mammals), we appreciate the enormous complexity of the circadian programme in organisms and cells, as well as in physiological and molecular circuits. Many of our insights into this complexity stem from experimental reductionism that goes as far as testing the interaction of molecular clock components in heterologous systems or in vitro . The results of this enormous endeavour show circadian systems that involve several oscillators, multiple input pathways and feedback loops that contribute to specific circadian qualities but not necessarily to the generation of circadian rhythmicity. For a full appreciation of the circadian programme, the results from different levels of the system eventually have to be put into the context of the organism as a whole and its specific temporal environment. This review summarizes some of the complexities found at the level of organisms, cells and molecules, and highlights similar strategies that apparently solve similar problems at the different levels of the circadian system.

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Schulz, Pierre, e Thierry Steimer. "Neurobiology of Circadian Systems". CNS Drugs 23, Supplement 2 (setembro de 2009): 3–13. http://dx.doi.org/10.2165/11318620-000000000-00000.

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Foster, Russell G. "Photoreceptors and Circadian Systems". Current Directions in Psychological Science 2, n.º 2 (abril de 1993): 34–39. http://dx.doi.org/10.1111/1467-8721.ep10770677.

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Roenneberg, Till, e Martha Merrow. "Circadian Systems and Metabolism". Journal of Biological Rhythms 14, n.º 6 (dezembro de 1999): 449–59. http://dx.doi.org/10.1177/074873099129001019.

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Lee, Junghyun, Sevde Goker, Sookkyung Lim e Christian I. Hong. "Development of circadian rhythms in mammalian systems". Biochemical Journal 481, n.º 24 (23 de dezembro de 2024): 1967–76. https://doi.org/10.1042/bcj20210060.

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In mammals, molecular mechanisms of circadian rhythms involve a time-delayed negative feedback loop generating autonomous oscillations of ∼24 h. Most cell types in mammals possess circadian rhythms regulating temporal organization of cellular and physiological processes. Intriguingly, pluripotent stem cells do not possess circadian rhythms and oscillations arise after a defined period of differentiation. Previous studies demonstrated that post-transcriptional regulations of core clock components, CLOCK and PER2, play critical roles in inducing circadian rhythms. In this article, we review the development of circadian rhythms in mammalian systems and provide a theoretical understanding of potential mechanisms regulating the birth of circadian rhythms using mathematical modeling.

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Kalustova, D., V. Kornaga, A. Rybalochka e S. Valyukh. "Space of visual and circadian parameters of RGBW lighting systems". Lighting engineering and power engineering 1, n.º 57 (6 de abril de 2020): 16–21. http://dx.doi.org/10.33042/2079-424x-2020-1-57-16-21.

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Due to the proven effect of light on human circadian rhythms, nowadays researchers and developers of lighting systems (LS) concentrate on the non-visual parameters of light and methods of ensuring a safe comfortable light environment. This requires optimisation of spectral power distribution (SPD). In this view the most promising and functional are RGBW systems due to their ability to change dynamically SPD and, hence, light parameters. In this work we explore two RGBW (red-greenblue-white) systems with different white LEDs (warm white and neutral white) and the space of visual and non-visual parameters that they can ensure. Visual parameters are studied in terms of colour rendering index, colour fidelity index and visual corneal illuminance while non-visual parameters are studied in terms of circadian light, circadian stimulus and circadian action factor. These parameters are calculated for different contribution of the components in a correlated colour temperature (CCT) range of 2500 – 7000K. In addition, acceptable criterion of the colour fidelity index above 85 is used. It is shown that under this condition the circadian action factor in the range of 0.33-0.98 can be obtained by changing the CCT and (or) colour fidelity index. Also an achievable area of the circadian stimulus versus corneal illuminance space for RGBW systems is found. It enables to choose optimal combination of CCT, circadian stimulus and corneal illuminance to provide the desired level of circadian effect with sufficient visual comfort depending on the daytime and field of system's implementation. This data is useful for LS manufacturers and lighting designers to create a comfortable lighting environment. Keywords - RGBW colour mixing, tunable white light, circadian effect, colour rendering, colour fidelity index.

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Hubbard, Katharine E., Fiona C. Robertson, Neil Dalchau e Alex A. R. Webb. "Systems analyses of circadian networks". Molecular BioSystems 5, n.º 12 (2009): 1502. http://dx.doi.org/10.1039/b907714f.

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Lin, L. L., H. C. Huang e H. F. Juan. "Circadian systems biology in Metazoa". Briefings in Bioinformatics 16, n.º 6 (10 de março de 2015): 1008–24. http://dx.doi.org/10.1093/bib/bbv006.

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Neumann, Anne-Marie, Cosima Xenia Schmidt, Ruth Merle Brockmann e Henrik Oster. "Circadian regulation of endocrine systems". Autonomic Neuroscience 216 (janeiro de 2019): 1–8. http://dx.doi.org/10.1016/j.autneu.2018.10.001.

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Tsang, Anthony H., Johanna L. Barclay e Henrik Oster. "Interactions between endocrine and circadian systems". Journal of Molecular Endocrinology 52, n.º 1 (30 de agosto de 2013): R1—R16. http://dx.doi.org/10.1530/jme-13-0118.

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In most species, endogenous circadian clocks regulate 24-h rhythms of behavior and physiology. Clock disruption has been associated with decreased cognitive performance and increased propensity to develop obesity, diabetes, and cancer. Many hormonal factors show robust diurnal secretion rhythms, some of which are involved in mediating clock output from the brain to peripheral tissues. In this review, we describe the mechanisms of clock–hormone interaction in mammals, the contribution of different tissue oscillators to hormonal regulation, and how changes in circadian timing impinge on endocrine signalling and downstream processes. We further summarize recent findings suggesting that hormonal signals may feed back on circadian regulation and how this crosstalk interferes with physiological and metabolic homeostasis.

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Teses / dissertações sobre o assunto "Circadian systems"

Damineli, Daniel Santa Cruz. "Synchronization properties of multi-oscillator circadian systems". Doctoral thesis, Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica, 2014. http://hdl.handle.net/10362/13561.

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Dissertation presented to obtain the Ph.D degree in Computational Biology
Circadian oscillators are usually regarded as time-keeping mechanisms that can synchronize to environmental cycles (zeitgebers) and coordinate the timing of virtually all aspects of organismal function. Circadian pacemakers would be the main time-keepers that synchronize to light/dark cycles and convey temporal information to peripheral oscillators. However, the idea of circadian systems as being simple clocks is challenged by the coexistence, within the same organism, of multiple circadian oscillators with diverse synchronization strategies.(...)
Fundação para a Ciência e a Tecnologia (FCT)

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Locke, James C. W. "A systems biology approach to the Arabidopsis circadian clock". Thesis, University of Warwick, 2006. http://wrap.warwick.ac.uk/58550/.

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Circadian clocks involve feedback loops that generate rhythmic expression of key genes. Molecular genetic studies in the higher plant Arabidopsis theliene have revealed a complex clock network. We begin by modelling the first part of the Arabidopsis clock network to be identified, a transcriptional feedback loop comprising TIMING OF CAB EXPRESSION 1 (TOCl), LATE ELONGATED HYPOCOTYL (LHY) and CIRCADIAN CLOCK ASSOCIATED 1 (CCA1). As for many biological systems, there are no experimental values for the parameters in our model, and the data available for parameter fitting is noisy and varied. To tackle this we construct a cost function, which quantifies the agreement between our model and various key experimental features. We then undertake a global search of parameter space, to test whether the proposed circuit can fit the experimental data. Our optimized solution for the Arabidopsis clock model is unable to account for significant experimental data. Thanks to our search of parameter space, we are able to interpret this as a failure of the network architecture. We develop an extended clock model that is based upon a wider range of data and accurately predicts additional experimental results. The model comprises two interlocking feedback loops comparable to those identified experimentally in other circadian systems. We propose that each loop receives input signals from light, and that each loop includes a hypothetical component that had not been explicitly identified. Analysis of the model predicts the properties of these components, including an acute light induction at dawn that is rapidly repressed by LHY and CCAL We find this unexpected regulation in RNA levels of the evening-expressed gene GIGANTEA (GI), supporting our proposed network and making GI a strong candidate for this component. We go on to develop reduced models of the Arabidopsis clock to aid conceptual understanding, and add a further proposed feedback loop to develop a 3-loop model of the circadian clock. This 3-loop model is able to reproduce further key experimental data.

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Brager, Allison Joy. "Roles of the circadian and reward systems in alcoholism". Kent State University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=kent1306869438.

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Ton, That Long. "Nonlinear control studies for circadian models in system biology". Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/nonlinear-control-studies-for-circadian-models-in-system-biology(f616f360-99e4-4314-ba51-be7a49e9ff0e).html.

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Circadian rhythms exist in almost all of living species, and they occupy an important role in daily biological activities of these species. This thesis deals with reduction of measurements in circadian models, and recovery of circadian phases. Two mathematical models of circadian rhythms are considered, with a 3rd order model for Neurospora, and a 7th order model for Mammals. The reduction of measurements of circadian models is shown by the proposals of observer designs to the two mathematical models of circadian rhythms. Both mathematical models contain strong nonlinearities, which make the observer design challenging. Two observer designs, reduced-order and one-sided Lipschitz, are applied to the circadian models to tackle the nonlinearities. Reduced-order observer design is based on a state transformation to make certain nonlinearities have no impact on the observer errors, and the design of one-sided Lipschitz observer is based on systems with one-sided Lipschitz nonlinearities. Both observer designs are based on the existing methods in literature. The existing method of reduced-order observer has been applied to a class of multi-output nonlinear systems. A new reduced-order observer design which extends the existing one in literature is presented in this thesis. In this new reduced-order observer method, the observer error dynamics can be designed by choosing the observer gain, unlike the existing one, of which the observer error dynamics depend on the invariant zeros under certain input-output map. The recovery of circadian phases is carried out to provide a solution to phase shifts occurred in circadian disorders. The restoration of circadian phases is performed by the synchronizations of trajectories of a controlled model with trajectories of a reference model. The reference model and the controlled model have phase differences, and both these models are based on a given 3rd order model of Neurospora circadian rhythms. The phase differences are reflected by different initial conditions, and by parameter uncertainty. The synchronizations of the two models are performed by using back-stepping method for the case of different initial conditions, and by using adaptive back-stepping method for the remaining case. Several simulation studies of the proposed observer designs and the proposed schemes of synchronizations are carried out with the results shown in this thesis.

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Pearson, Kristen A. "Circadian rhythms, fatigue, and manpower scheduling". Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 2004. http://library.nps.navy.mil/uhtbin/hyperion/04Dec%5FPearson.pdf.

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Trané, Camilla. "Robustness Analysis of Intracellular Oscillators with Application to the Circadian Clock". Licentiate thesis, KTH, Automatic Control, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4815.

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Periodic oscillations underlie many intracellular functions, such as circadian time keeping, cell cycle control and locomotor pattern generation in nerve cells. These intracellular oscillations are generated in intricate biochemical reaction networks involving genes, proteins and other biochemical components. In most cases, robust oscillations are of pivotal importance for the organism, i.e., the oscillations must be maintained in the presence of internal and external perturbations.

Model based analysis of robustness in intracellular oscillators has attracted considerable attention in recent years. The analysis has almost exclusively been based on either complete removal of network components, e.g., single genes, or perturbation of model parameters. In this thesis, a control theoretic approach to analyze structural robustness of intracellular oscillators is proposed. The method is based on adding dynamic perturbations to the network interactions. Determination of the smallest perturbation translating the underlying steady-state into a Hopf bifurcation point is used to quantify the robustness. The method can be used to determine critical substructures within the overall network and to identify specific network fragilities. Also, an approach to nonlinear model reduction based on the robustness analysis is proposed.

The proposed robustness analysis method is applied to elucidate mechanisms underlying robust oscillations in circadian clocks. Circadian clocks, molecular oscillators generating 24 hour rhythms in many organisms, are known to display a striking robustness towards internal and external perturbations. The underlying networks involve a large number of genes that are transcribed into mRNA which produce proteins subsequently regulating the activity of other genes, together forming an intricate network with a large number of embedded feedback loops. An often recurring hypothesis is that the interlocked feedback loop structure of circadian clocks serves the purpose of robustness. From analysis of several recently published models of circadian clocks, it is found in this thesis that the robustness of circadian clocks primarily results from a high gain in a single gene regulatory feedback loop generating the oscillations. This gain can be elevated by additional feedback loops, involving either gene regulation or post-translational feedback, but a similar robustness can be achieved by simply increasing the amplification within the master feedback loop.

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Bellman, Jacob. "Phase Response Optimization of the Circadian Clock in Neurospora crassa". University of Cincinnati / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1459438726.

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Jin, Junyang. "Novel methods for biological network inference : an application to circadian Ca2+ signaling network". Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/285323.

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Biological processes involve complex biochemical interactions among a large number of species like cells, RNA, proteins and metabolites. Learning these interactions is essential to interfering artificially with biological processes in order to, for example, improve crop yield, develop new therapies, and predict new cell or organism behaviors to genetic or environmental perturbations. For a biological process, two pieces of information are of most interest. For a particular species, the first step is to learn which other species are regulating it. This reveals topology and causality. The second step involves learning the precise mechanisms of how this regulation occurs. This step reveals the dynamics of the system. Applying this process to all species leads to the complete dynamical network. Systems biology is making considerable efforts to learn biological networks at low experimental costs. The main goal of this thesis is to develop advanced methods to build models for biological networks, taking the circadian system of Arabidopsis thaliana as a case study. A variety of network inference approaches have been proposed in the literature to study dynamic biological networks. However, many successful methods either require prior knowledge of the system or focus more on topology. This thesis presents novel methods that identify both network topology and dynamics, and do not depend on prior knowledge. Hence, the proposed methods are applicable to general biological networks. These methods are initially developed for linear systems, and, at the cost of higher computational complexity, can also be applied to nonlinear systems. Overall, we propose four methods with increasing computational complexity: one-to-one, combined group and element sparse Bayesian learning (GESBL), the kernel method and reversible jump Markov chain Monte Carlo method (RJMCMC). All methods are tested with challenging dynamical network simulations (including feedback, random networks, different levels of noise and number of samples), and realistic models of circadian system of Arabidopsis thaliana. These simulations show that, while the one-to-one method scales to the whole genome, the kernel method and RJMCMC method are superior for smaller networks. They are robust to tuning variables and able to provide stable performance. The simulations also imply the advantage of GESBL and RJMCMC over the state-of-the-art method. We envision that the estimated models can benefit a wide range of research. For example, they can locate biological compounds responsible for human disease through mathematical analysis and help predict the effectiveness of new treatments.

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Carignano, Alberto. "Genome wide analysis of differentially expressed systems : an application to circadian networks". Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708703.

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Urquiza, García José María Uriel. "Mathematical model in absolute units for the Arabidopsis circadian oscillator". Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31132.

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The Earth’s oblique rotation results in changes in light and temperature across the day and time of year. Living organisms evolved rhythmic behaviours to anticipate these changes and execute appropriate responses at particular times. The current paradigm for the biological clocks in several branches of life is an underlying biochemical oscillator mainly composed by a network of repressive transcription factors. The slow decay in their activity is fundamental for generating anticipatory dynamics. Interestingly, these dynamics can be well appreciated when the biological system is left under constant environmental conditions, where oscillation of several physiological readouts persists with a period close to 24 hours, hence the term “circadian clocks”, circa=around dian=day. In plants the model species Arabidopsis thaliana has served as an invaluable tool for analysing the genetics, biochemical, developmental, and physiological effects of the oscillator. Many of these experimental results have been integrated in mechanistic and mathematical theories for the circadian oscillator. These models predict the timing of gene expression and protein presence in several genetic backgrounds and photoperiodic conditions. The aim of this work is the introduction of a correct mass scale for both the RNA transcript and protein variables of the clock models. The new mass scale is first introduced using published RNA data in absolute units, from qRT-PCR. This required reinterpreting several assumptions of an established clock model (P2011), resulting in an updated version named U2017. I evaluate the performance of the U2017 model in using data in absolute mass units, for the first time for this clock system. Introducing absolute units for the protein variables takes place by generating hypothetical protein data from the existing qRT-PCR data and comparing a data-driven model with western blot data from the literature. I explore the consequences of these predicted protein numbers for the model’s dynamics. The process required a meta-analysis of plant parameter values and genomic information, to interpret the biological relevance of the updated protein parameters. The predicted protein amounts justify, for example, the revised treatment of the Evening Complex in the U2017 model, compared to P2011. The difficulties of introducing absolute units for the protein components are discussed and components for experimental quantification are proposed. Validating the protein predictions required a new methodology for absolute quantification. The methodology is based on translational fusions with a luciferase reporter than has been little used in plants, NanoLUC. Firstly, the characterisation of NanoLUC as a new circadian reporter was explored using the clock gene BOA. The results show that this new system is a robust, sensitive and automatable approach for addressing quantitative biology questions. I selected five clock proteins CCA1, LHY, PRR7, TOC1 and LUX for absolute quantification using the new NanoLUC methodology. Functionality of translation fusions with NanoLUC was assessed by complementation experiments. The closest complementing line for each gene was selected to generate protein time series data. Absolute protein quantities were determined by generation of calibration curves using a recombinant NanoLUC standard. The developed methodology allows absolute quantification comparable to the calibrated qRT-PCR data. These experimental results test the predicted protein amounts and represent a technical resource to understand protein dynamics of Arabidopsis’ circadian oscillator quantitatively. The new experimental, meta-analysis and modelling results in absolute units allows future researchers to incorporate further, quantitative biochemical data.

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Livros sobre o assunto "Circadian systems"

Guo, Xinfei, e Mircea R. Stan. Circadian Rhythms for Future Resilient Electronic Systems. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-20051-0.

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Ripkens, Michael. Untersuchung zur Vorhersage der Resynchronisation des zirkadianen Systems nach transmeridianen Flugen. Koln: DFVLR, 1989.

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Aguilar-Roblero, Raúl, Mauricio Díaz-Muñoz e Mária Luisa Fanjul-Moles, eds. Mechanisms of Circadian Systems in Animals and Their Clinical Relevance. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-08945-4.

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Rensing, Ludger. Temporal Disorder in Human Oscillatory Systems: Proceedings of an International Symposium University of Bremen, 8-13 September 1986. Berlin, Heidelberg: Springer Berlin Heidelberg, 1987.

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Ludger, Rensing, Heiden, Uwe an der, 1942- e Mackey Michael C. 1942-, eds. Temporal disorder in human oscillatory systems: Proceedings of an international symposium, University of Bremen, 8-13 September 1986. Berlin: Springer-Verlag, 1987.

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H, Monk Timothy, e American Nurses Association, eds. The nurse's shift work handbook. Washington, D.C: American Nurses Pub., 1993.

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Redfern, P. H., I. C. Campbell, J. A. Davies e K. F. Martin, eds. Circadian Rhythms in the Central Nervous System. London: Palgrave Macmillan UK, 1985. http://dx.doi.org/10.1007/978-1-349-07837-0.

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H, Redfern P., e IUPHAR International Congress of Pharmacology, (9th : 1984 : London), eds. Circadian rhythms in the central nervous system. Weinheim: VCH, 1985.

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1942-, Redfern P. H., International Union of Pharmacology e International Congress of Pharmacology (9th : 1984 : London, England), eds. Circadian rhythms in the central nervous system. Deerfield Beach, FL, USA: Distribution for USA and Canada, VCH Publishers, 1985.

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1942-, Redfern P. H., International Union of Pharmacology e International Congress of Pharmacology (9th : 1984 : London, England), eds. Circadian rhythms in the central nervous system. Houndmills, Basingstoke, Hampshire: Macmillan, 1985.

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Capítulos de livros sobre o assunto "Circadian systems"

Reddy, Akhilesh B. "Genome-Wide Analyses of Circadian Systems". In Circadian Clocks, 379–88. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-25950-0_16.

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Lei, Jinzhi. "Circadian Rhythm". In Encyclopedia of Systems Biology, 406–7. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-9863-7_535.

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d’Eysmond, Thomas, e Felix Naef. "Systems Biology and Modeling of Circadian Rhythms". In The Circadian Clock, 283–93. New York, NY: Springer New York, 2009. http://dx.doi.org/10.1007/978-1-4419-1262-6_11.

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Page, Terry L. "Circadian Systems of Invertebrates". In Handbook of Behavioral Neurobiology, 79–110. Boston, MA: Springer US, 2001. http://dx.doi.org/10.1007/978-1-4615-1201-1_5.

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Thiriet, Marc. "Circadian Clock". In Control of Cell Fate in the Circulatory and Ventilatory Systems, 329–56. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4614-0329-6_5.

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Petiau-de Vries, Ghislaine M. "Membrane Glycosylation and Circadian Rhythms in Plant Systems and in Animal Normal and Transformed Systems". In Membranes and Circadian Rythms, 47–66. Berlin, Heidelberg: Springer Berlin Heidelberg, 1996. http://dx.doi.org/10.1007/978-3-642-79903-7_3.

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Kim, Jae Kyoung. "Tick, Tock, Circadian Clocks". In Case Studies in Systems Biology, 79–94. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-67742-8_6.

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Roenneberg, T., e M. Merrow. "The Circadian Systems of Cells". In Biological Rhythms, 60–70. Berlin, Heidelberg: Springer Berlin Heidelberg, 2002. http://dx.doi.org/10.1007/978-3-662-06085-8_6.

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Buijs, Ruud M., Eva Soto-Tinoco e Andries Kalsbeek. "Circadian Control of Neuroendocrine Systems". In Masterclass in Neuroendocrinology, 297–315. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-86630-3_11.

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Daan, Serge, e Jürgen Aschoff. "The Entrainment of Circadian Systems". In Handbook of Behavioral Neurobiology, 7–43. Boston, MA: Springer US, 2001. http://dx.doi.org/10.1007/978-1-4615-1201-1_2.

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Trabalhos de conferências sobre o assunto "Circadian systems"

Dos Santos, Angélica T., Catia M. S. Machado e Diana F. Adamatti. "Circadian rhythm and pain: a modeling using multiagent systems". In XV Encontro Nacional de Inteligência Artificial e Computacional. Sociedade Brasileira de Computação - SBC, 2018. http://dx.doi.org/10.5753/eniac.2018.4450.

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The circadian rhythm is responsible for the daily routines without metabolism and its disorders have great repercussion, such as obesity and mental disorders. This study is, the work approach has metate the study of synchronization and synchronization cycle circadian and influenced the variable of the, in the perspective of an integrated system with an computational system and computational. Results show the circadian rhythm periodicity is modified by the pain variable.

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AXMANN, ILKA M., STEFAN LEGEWIE e HANSPETER HERZEL. "A MINIMAL CIRCADIAN CLOCK MODEL". In Proceedings of the 7th Annual International Workshop on Bioinformatics and Systems Biology (IBSB 2007). IMPERIAL COLLEGE PRESS, 2007. http://dx.doi.org/10.1142/9781860949920_0006.

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Sadekar, Prachi, Jackson Baitinger, Sean Conway, Matthew Clark e Afsaneh Doryab. "Personalization in Circadian Rhythm-Based Event Scheduling". In 2023 Systems and Information Engineering Design Symposium (SIEDS). IEEE, 2023. http://dx.doi.org/10.1109/sieds58326.2023.10137806.

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Kurosawa, Gen, Kazuyuki Aihara e Yoh Iwasa. "Bifurcation analyses in the cyanobacterial circadian clock model". In 2006 IEEE/NLM Life Science Systems and Applications Workshop. IEEE, 2006. http://dx.doi.org/10.1109/lssa.2006.250394.

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Somalakshmi, K., Revathi Venkataraman, N. Shalin, M. Jerome Samrai e M. Viveka. "Rhythm Monitor - A Wearable for Circadian Health Monitoring". In 2022 International Conference on Electronic Systems and Intelligent Computing (ICESIC). IEEE, 2022. http://dx.doi.org/10.1109/icesic53714.2022.9783609.

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"Mathematical and numerical modelling of the circadian oscillator". In Bioinformatics of Genome Regulation and Structure/Systems Biology (BGRS/SB-2022) :. Institute of Cytology and Genetics, the Siberian Branch of the Russian Academy of Sciences, 2022. http://dx.doi.org/10.18699/sbb-2022-657.

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"Seven-day Analysis of Atrial Fibrillation and Circadian Rhythms". In International Conference on Bio-inspired Systems and Signal Processing. SciTePress - Science and and Technology Publications, 2013. http://dx.doi.org/10.5220/0004191400200024.

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Köhler, M., C. Mivashita, A. Friedl, S. Littbarski, M. Heiden e E. Wenzel. "ENDOGENOUS CIRCADIAN RHYTHM OF FIBRINOLYTIC PARAMETERS". In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644840.

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Recently, the fibrinolytic system was shown to be dependent on complex interactions of several proteins for which specific test systems have been developed. We report on the results in placebo groups of two drug trials which strongly suggest an endogenous circadian rhythm of these parameters. In the first trial, 6 male subjects consecutively received either different heparins or placebo (group A). In a double blind placebo controlled trial, 10 male subjects received either DDAVP or placebo (group B). Blood was obtained before (7:30 a.m.), and 1, 2, 3, 4, 6, 9, 12 h and, only in group A, 15 and 24 h after the injection (8:00 a.m.). Euglobulin precipitate (EP) was prepared immediately after centrifugation. Fibrinolytic activity (FA) and t-PA activity were measured according to Astrup and Miillertz (1952) and Verheijen et al.(l982), respectively. t-PA antigen was measured using a kit from Biopool, Umea. t-PA-inhibitor (INH) was determined using a commercial kit from Kabivitrum and the method described by Chmielewska et al.(l983). Statistical analysis was performed using ANOVA (t-PA antigen) and Kruskal-Wal1is test.Results: In group A, t-PA antigen was significantly higher in the morning than in the evening. In contrast, t-PA activity and FA were low in the morning and gradually increased and reached maxima at 8 p.m. and 11 p.m., respectively. In group B, the same pattern was observed and all diurnal variations were statistically significant. Higher levels of t-PA-INH and t-PA-antigen were observed in the morning, and lower levels of t-PA and fibrinolytic activity. A reversed pattern was seen in the evening ( 8 p.m.). The two different methods for t-PA measurements showed the same variation^ although a c.lO-fold higher level was determined using the Kabivitrum test kit.

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Foo, Mathias, Hee Young Yoo e Pan-Jun Kim. "System identification of circadian clock in plant Arabidopsis thaliana". In 2013 13th International Conference on Control, Automaton and Systems (ICCAS). IEEE, 2013. http://dx.doi.org/10.1109/iccas.2013.6703901.

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Deli, Alceste, Mayela Zamora, John E. Fleming, Amir Divanbeighi Zand, Moaad Benjaber, Alexander L. Green e Timothy Denison. "Bioelectronic Zeitgebers: Targeted Neuromodulation to Re-Establish Circadian Rhythms". In 2023 IEEE International Conference on Systems, Man, and Cybernetics (SMC). IEEE, 2023. http://dx.doi.org/10.1109/smc53992.2023.10394632.

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Relatórios de organizações sobre o assunto "Circadian systems"

Doyle III, Francis J. Multiscale Problems in Circadian Systems Biology: From Gene to Cell to Performance. Fort Belvoir, VA: Defense Technical Information Center, março de 2012. http://dx.doi.org/10.21236/ada570943.

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Moore, Robert Y. Organization of the Human Circadian System. Fort Belvoir, VA: Defense Technical Information Center, maio de 1994. http://dx.doi.org/10.21236/ada288223.

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Moore, Robert Y. Organization of the Human Circadian System. Fort Belvoir, VA: Defense Technical Information Center, maio de 1994. http://dx.doi.org/10.21236/ada288468.

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Moore, Robert Y. Organization of the Human Circadian System. Fort Belvoir, VA: Defense Technical Information Center, maio de 1996. http://dx.doi.org/10.21236/ada311778.

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Moore, Robert Y. Organization of the Human Circadian System. Fort Belvoir, VA: Defense Technical Information Center, janeiro de 2001. http://dx.doi.org/10.21236/ada387044.

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Rafaeli, Ada, Wendell Roelofs e Anat Zada Byers. Identification and gene regulation of the desaturase enzymes involved in sex-pheromone biosynthesis of pest moths infesting grain. United States Department of Agriculture, março de 2008. http://dx.doi.org/10.32747/2008.7613880.bard.

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The original objectives of the approved proposal included: 1. Establishment of the biosynthetic pathways for pheromone production using labeled precursors and GC-MS. 2. The elucidation of a circadian regulation of key enzymes in the biosynthetic pathway. 3. The identification, characterization and confirmation of functional expression of the delta-desaturases. 4. The identification of gene regulatory processes involved in the expression of the key enzymes in the biosynthetic pathway. Background to the topic: Moths constitute one of the major groups of pest insects in agriculture and their reproductive behavior is dependent on chemical communication. Sex-pheromone blends are utilized by a variety of moth species to attract conspecific mates. The sex pheromones used are commonly composed of blends of aliphatic molecules that vary in chain length, geometry, degree and position of double bonds and functional groups. They are formed by various actions of specific delta-desaturases to which chain shortening, elongation, reduction, acetylation, and oxidation of a common fatty acyl precursor is coupled. In most of the moth species sex-pheromone biosynthesis is under circadian control by the neurohormone, PBAN (pheromone-biosynthesis-activating neuropeptide). The development of specific and safe insect control strategies utilizing pheromone systems depends on a clear knowledge of the molecular mechanisms involved. In this proposal we aimed at identifying and characterizing specific desaturases involved in the biosynthetic pathway of two moth pest-speciesof stored products, P. interpunctella and S. cerealella, and to elucidate the regulation of the enzymes involved in pheromone biosynthesis. Due to technical difficulties the second stored product pest was excluded from the study at an early phase of the research project. Major conclusions: Within the framework of the planned objectives we confirmed the pheromone biosynthetic pathway of P. interpunctella and H. armigera by using labeled precursor molecules. In addition, in conjunction with various inhibitors we determined the PBAN-stimulated rate-limiting step for these biosynthetic pathways. We thereby present conclusive evidence that the enzyme Acetyl Coenzyme A Carboxylase is activated as a result of PBAN stimulation. We also found that P. interpunctella produce the main pheromone component Z9, E12 Tetradecenyl acetate through the action of a D11 desaturase working on the 16:Acid precursor. This is evidenced by the high amount of incorporation of ²H-labeled 16:Acid into pheromone when compared to the incorporation of ²H-labeled 14:Acid. However, in contrast to reports on other moth species, P. interpunctella is also capable of utilizing the 14:Acid precursor, although to a much lesser extent than the 16:Acid precursor. Despite the discovery of nine different desaturase gene transcripts in this species, from the present study it is evident that although PCR detected all nine gene transcripts, specific to female pheromone glands, only two are highly expressed whereas the other 7 are expressed at levels of at least 10⁵ fold lower showing very low abundance. These two genes correspond to D11-like desaturases strengthening the hypothesis that the main biosynthetic pathway involves a D11 desaturase.

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Baker, T. L., D. Morisseau e N. M. Murphy. Use of Circadian Lighting System to improve night shift alertness and performance of NRC Headquarters Operations Officers. Office of Scientific and Technical Information (OSTI), abril de 1995. http://dx.doi.org/10.2172/90926.

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Wagner, D. Ry, Eliezer Lifschitz e Steve A. Kay. Molecular Genetic Analysis of Flowering in Arabidopsis and Tomato. United States Department of Agriculture, maio de 2002. http://dx.doi.org/10.32747/2002.7585198.bard.

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The primary objectives for the US lab included: the characterization of ELF3 transcription and translation; the creation and characterization of various transgenic lines that misexpress ELF3; defining genetic pathways related to ELF3 function regulating floral initiation in Arabidopsis; and the identification of genes that either interact with or are regulated by ELF3. Light quality, photoperiod, and temperature often act as important and, for some species, essential environmental cues for the initiation of flowering. However, there is relatively little information on the molecular mechanisms that directly regulate the developmental pathway from the reception of the inductive light signals to the onset of flowering and the initiation of floral meristems. The ELF3 gene was identified as possibly having a role in light-mediated floral regulation since elj3 mutants not only flower early, but exhibit light-dependent circadian defects. We began investigating ELF3's role in light signalling and flowering by cloning the ELF3 gene. ELF3 is a novel gene only present in plant species; however, there is an ELF3 homolog within Arabidopsis. The Arabidopsis elj3 mutation causes arrhythmic circadian output in continuous light; however, we show conclusively normal circadian function with no alteration of period length in elj3 mutants in dark conditions and that the light-dependent arrhythmia observed in elj3 mutants is pleiotropic on multiple outputs regardless of phase. Plants overexpressing ELF3 have an increased period length in constant light and flower late in long-days; furthermore, etiolated ELF3-overexpressing seedlings exhibit a decreased acute CAB2 response after a red light pulse, whereas the null mutant is hypersensitive to acute induction. This finding suggests that ELF3 negatively regulates light input to both the clock and its outputs. To determine whether ELF3's action is phase dependent, we examined clock resetting by light pulses and constructed phase response curves. Absence of ELF3 activity causes a significant alteration of the phase response curve during the subjective night, and overexpression of ELF3 results in decreased sensitivity to the resetting stimulus, suggesting that ELF3 antagonizes light input to the clock during the night. Indeed, the ELF3 protein interacts with the photoreceptor PHYB in the yeast two-hybrid assay and in vitro. The phase ofELF3 function correlates with its peak expression levels of transcript and protein in the subjective night. ELF3 action, therefore, represents a mechanism by which the oscillator modulates light resetting. Furthermore, flowering time is dependent upon proper expression ofELF3. Scientifically, we've made a big leap in the understanding of the circadian system and how it is coupled so tightly with light reception in terms of period length and clock resetting. Agriculturally, understanding more about the way in which the clock perceives and relays temporal information to pathways such as those involved in the floral transition can lead to increased crop yields by enabling plants to be grown in suboptimal conditions.

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