Literatura científica selecionada sobre o tema "Ciblage du bas TGI"
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Artigos de revistas sobre o assunto "Ciblage du bas TGI"
Hakik, Idriss. "ESSAI DE DETERMINATION DUN TAUX OPTIMAL DINFLATION AU MAROC". International Journal of Advanced Research 9, n.º 5 (31 de maio de 2021): 994–1009. http://dx.doi.org/10.21474/ijar01/12935.
Texto completo da fonteDejemeppe, Muriel, e Bruno Van der Linden. "Numéro 118 - octobre 2015". Regards économiques, 12 de outubro de 2018. http://dx.doi.org/10.14428/regardseco.v1i0.14463.
Texto completo da fonteDejemeppe, Muriel, e Bruno Van der Linden. "Numéro 118 - octobre 2015". Regards économiques, 12 de outubro de 2018. http://dx.doi.org/10.14428/regardseco2015.10.01.
Texto completo da fonteDejemeppe, Muriel, e Bruno Van der Linden. "Numéro 40 - avril 2006". Regards économiques, 12 de outubro de 2018. http://dx.doi.org/10.14428/regardseco.v1i0.15873.
Texto completo da fonteDejemeppe, Muriel, e Bruno Van der Linden. "Numéro 40 - avril 2006". Regards économiques, 12 de outubro de 2018. http://dx.doi.org/10.14428/regardseco2006.04.01.
Texto completo da fonteSneessens, Henri, e Bruno Van der Linden. "Numéro 33 - septembre 2005". Regards économiques, 12 de outubro de 2018. http://dx.doi.org/10.14428/regardseco.v1i0.15943.
Texto completo da fonteSneessens, Henri, e Bruno Van der Linden. "Numéro 33 - septembre 2005". Regards économiques, 12 de outubro de 2018. http://dx.doi.org/10.14428/regardseco2005.09.02.
Texto completo da fonteTeses / dissertações sobre o assunto "Ciblage du bas TGI"
Strich, Samuel. "Oral drug delivery systems based on polysaccharides for colon targeting". Electronic Thesis or Diss., Université de Lille (2022-....), 2023. http://www.theses.fr/2023ULILS081.
Texto completo da fonte10 million people worldwide, over 1.5 million in North America and 2 million in Europe. Those are the numbers of people affected by inflammatory bowel disease (IBD) in each region quoted, respectively. Including both Crohn's disease (CD) and ulcerative colitis (UC), inflammatory bowel disease has emerged as a public health challenge worldwide in the past decades. Often diagnosed between 15 and 35 years old, IBD are characterized by moderate to severe symptoms, and have in common relapsing-remitting cycles of mucosal inflammation.To date, there is no cure for IBD. Defined as colon targeting, targeted drug delivery systems is a way to get selective and efficient delivery of pharmacologically active compounds to the predetermined targeted region in therapeutic concentrations along with minimizing side effects of the drug. Current strategies for colon targeting rely on : *) prodrugs, **) pH-dependant systems, ***) time-dependant systems, ****) microbially triggered systems.Of all approaches, microbiota sensitive systems are currently known as the best ones for colonic drug delivery. It is also possible to combine several complementary approaches (pH- and microbiota sensitive) to significantely favor localized drug release.Our project aimed to develop 5 mm mini-tablets for colon targeting. First, a comparison of different film coatings was made to highlight the most interesting drug release profiles. Then, an innovative formulation, combining synthetic and natural polymers as well as polysaccharides, was evaluated. Different blend ratios were selected as well for films as for coated mini-tablets. In vitro drug release was carried out in simulated digestive fluids for a 32 h duration, including:- 0.1 N HCl or simulated gastric fluid (2 h)- PBS 6.8 or simulated intestinal fluid (6 h)- Colonic simulated medium with and without patients' faeces (24 h).Colonic simulated medium inoculated with patients' faeces allowed for working closer to pathophysiological conditions. Relevant results were obtained and paved the way for a promising monolayer technology. None or negligible drug release occurred up to 8 h, in the upper GIT. Also, drug could be totally protected in the lower gastrointestinal tract.Ethylcellulose, as a thermoplastic polymer, prevented from premature dissolution.Shellac, as a natural resin, provided pH-dependant properties.The adjunction of a polysaccharide acted as a substrate of microbiota.Interestingly, colonic release profiles could be optimized depending on the amount of polysaccharide added into the system
Marie-Pierre, Hamel. "Les politiques d'accès aux droits sociaux : entre rationalisation budgétaire et lutte contre la pauvreté : une comparaison France, Pays-Bas, Royaume-Uni / Marie-Pierre Hamel". Phd thesis, Institut d'études politiques de paris - Sciences Po, 2009. http://tel.archives-ouvertes.fr/tel-00866930.
Texto completo da fonteAchour, Oussama. "Aide au ciblage du microenvironnement tumoral par le développement d’un nano-système de détection et de traitement des tumeurs avec inhibition ciblée de l’héparanase". Thesis, La Rochelle, 2014. http://www.theses.fr/2014LAROS012/document.
Texto completo da fonteTumor microenvironment is characterized by several particularities such as hypoxia, extracellular media acidification and the hyper-secretion of hydrolytic enzymes. These hydrolases, such as cathepsin D and heparanase, are involved in many steps of tumor progression like angiogenesis. This thesis is a part of a project that aims to develop a "smart" molecular nano-object that specifically reacts to hyper-secreted enzymes in the tumor microenvironment for the simultaneous detection and targeting of tumor. The first part of our work concerned the design and the validation of a peptide that is sensitive to active forms of cathepsin D which is a protease, unregulated in many tumors microenvironment such as breast cancers. This objective has been achieved following the kinetic study of the hydrolysis of 5 peptides by mature cathepsin D and procathepsin D in the pH conditions of the tumor microenvironment. On the other hand, we studied the effect of hypoxia and the acidification of the extracellular medium on the secretion of active forms of cathepsin D by the breast cancer cell line MCF-7. In a second part, we worked on the development of low molecular weight heparins that may provide therapeutic function of the molecular object through their anti-angiogenic activity. We have developed an innovative method for the depolymerization of heparin that consists on a radical hydrogen peroxide hydrolysis assisted by ultrasound. This technique allows the production of heparins oligosaccharides characterized by controlled molecular weight and degree of sulfatation. Depending on the depolymerization conditions by this technique, the produced low molecular weight heparins can be used as an anticoagulant or anti-angiogenic