Artigos de revistas sobre o tema "Carlos Gonzalez y Hermano"
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1
Residente, Residente. "Reumatología". Acta Médica Colombiana 43, n.º 2S (24 de junho de 2019): 240–75. http://dx.doi.org/10.36104/amc.2018.1406.
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R-1 NEUROPATÍA CRANEANA MÚLTIPLE COMO PRIMERA MANIFESTACIÓN DE SARCOIDOSIS - REPORTE DE CASO. (AGUDELO CARLOS, CORTÉS CAMILO)
R-2 DISECCIÓN CAROTÍDEA COMO CAUSA DE ATAQUE CEREBROVASCULAR EN PACIENTE JÓVEN CON SÍNDROME ANTIFOSFOLÍPIDO SECUNDARIO A LUPUS ERITEMATOSO SISTÉMICO (RICAURTE ANDRÉS, OCAMPO MARIA ISABEL, PENAGOS LAURA CONSTANZA, CAICEDO TOMÁS)
R-3 APROXIMACIÓN DIAGNÓSTICA EN AMILOIDOSIS SISTÉMICA (LEAL JANETH, QUEVEDO HENRY, JIMÉNEZ ANA, MONSALVE MÓNICA, JARAMILLO DANI)
R-4 LECCIONES APRENDIDAS EN EL DIAGNÓSTICO DE UN PACIENTE CON ENFERMEDAD DE STILL DEL ADULTO (RUMBO JOSÉ, RICAURTE ANDRÉS, TASSINARI STEFANO, CARRERO LAURA, PATIÑO LUISA, BUSTOS MARLON)
R-5 DIAGNOSTICO DIFERENCIAL DE TAPONAMIENTO CARDIACO APROPÓSITO DE UN CASO DE LUPUS DE INICIO TARDÍO (POVEDA GUSTAVO, ALZA JHONGERT, GARCÍA DIANA, ALZA LYZINHAWER)
R-6 ANEURISMA DE AORTA ABDOMINAL EN PACIENTE CON SOSPECHA DE SÍNDROME DE MARFÁN: REPORTE DE CASO EN EL HOSPITAL SANTA CLARA BOGOTÁ - COLOMBIA (ROMERO SANTIAGO, ROSADO KATIANA)
R-7 VASCULITIS OCULAR SECUNDARIO A GRANULOMATOSIS CON POLIANGITIS ANCAS NEGATIVOS (BEDOYA VANESSA, OSORIO LUIS M., SUÁREZ NATALIA A., RUEDA JORGE M., Y LIBREROS DIANA M)
R-8 ENCEFALITIS LIMBICA ASOCIADA A LUPUS ERITEMATOSO SISTÉMICO (SIERRA-MERLANO RITA-M, SEGOVIA-FUENTES JAVIER, RAMÍREZBARRANCO ROSANGELA, ÁLVAREZ-CASTRO MARÍA-FERNANDA)
R-9 NEUMONIA POR PNEUMOCYSTIS JIROVECII EN ARTRITIS REUMATOIDE (SIERRA-MERLANO RITA M, ARAUJO-OROZCO KARINA, RAMÍREZBARRANCO ROSANGELA)
R-10 MIOCARDIOPATIA INFILTRATIVA POR ANTIMALARICOS EN PACIENTE CON LUPUS ERITEMATOSO SISTÉMICO (GAMBA FERNANDO, GRISALES NATALIA, ORLAS CLAUDIA, ESPINOSA NATALIA, ESCARRIA DIANA, BACCA JOHANA, VEGA DAVID, GONZÁLEZ HERMAN, CUELLO HAROLD. URREA JUAN KARLO)
R-11 PSEUDOTUMOR PULMONAR COMO DEBUT CLÍNICO DE GRANULOMATOSIS CON POLIANGITIS (RINCÓN ÁLVAREZ EMILY, CONDE-CAMACHO RAFAEL E, JIMÉNEZ-CANIZALES CARLOS EDUARDO, PUENTES MARÍA ELSY, DOMÍNGUEZ JUAN DIEGO)
R-12 ENFERMEDAD RELACIONADA CON IGG4: ¿ES EL RITUXIMAB LA MEJOR ESTRATEGIA TERAPÉUTICA? RESULTADOS DE UNA REVISIÓN SISTEMÁTICA (DÍAZ-CORONADO JUAN C, ROJAS-VILLARRAGA ADRIANA, HERNANDEZ-PARRA DEICY, PEREZ-ESTRADA PAULA, BETANCURVÁSQUEZ LAURA, GONZALEZ-HURTADO DANIEL, ARANGO-ISAZADANIELA, CARMONA-SAMUEL)
R-13 LA IL-6 ES UN FACTOR CENTRAL EN LA ESCLEROSIS SISTÉMICA (ROJAS MANUEL, RODRÍGUEZ YHOJAN, PACHECO YOVANA, MONSALVE DIANA M., ACOSTA-AMPUDIA YENY, MÓNICA RODRÍGUEZ-JIMENEZ, RUBÉN D. MANTILLA, RAMÍREZ-SANTANA CAROLINA, ANAYA JUAN-MANUEL)
R-14 DE LA ECOLOGÍA AUTOINMUNE AL DESARROLLO DE POLIAUTOINMUNIDAD (ROJAS MANUEL, RODRÍGUEZ YHOJAN, PACHECO YOVANA, MONSALVE DIANA M., ACOSTA-AMPUDIA YENY, RAMÍREZ-SANTANA CAROLINA, ANAYA JUAN-MANUEL)
R-15 AUTOINMUNIDAD TIROIDEA EN INDIVIDUOS EUTIROIDEOS (RODRÍGUEZ YHOJAN, MONSALVE DIANA M., PACHECO YOVANA, ACOSTA-AMPUDIA YENY, ROJAS MANUEL, RODRÍGUEZ-JIMÉNEZ MÓNICA, MOLANO-GONZÁLEZ NICOLAS, RAMÍREZ-SANTANA CAROLINA, ANAYA JUAN-MANUEL)
R-16 POLIAUTOINMUNIDAD TIROIDEA EN EL SINDROME DE SJÖGREN (RESTREPO PAULA, BAYONA NATALIA, LEON KELLY, RODRÍGUEZ YHOJAN, CASTELLANOS LAURA, ZAPATA ESTEFANÍA, SÁNCHEZ JANNETH, ROJAS MANUEL, RAMÍREZ CAROLINA, MONSALVE DIANA, PACHECO YOVANA, ACOSTA YENY, RODRÍGUEZ MÓNICA, MOLANO NICOLÁS, ANAYA JUAN-MANUEL)
R-17 HIPERFERRITINEMIA y SINDROME FEBRIL PROLONGADO (CASTAÑEDA CAMACHO HÉCTOR ANDRES, PINILLA QUINTERO LADY SAMARA, MELO GUARÍN ASTRID ROCÍO, HIGUERA COBOS JUAN DIEGO)
R-18 SÍNDROME DE DEVIC (PEDRAZA MAURICIO, NAVARRETE LINDA, SOLÓRZANO CARLOS, SUPELANO MARIO, MÉNDEZ ALEJANDRO)
R-19 DE LA ARTRITIS REUMATOIDE AL HIPERCORTISOLISMO EXÓGENO (FERNÁNDEZ JORGE, CLAVIJO FAIR, SILVA O.)
R-20 VASCULITIS PRIMARIA SISTÉMICA COMO CAUSA DE FIEBRE DE ORIGEN DESCONOCIDO (FOD): REPORTE DE UN CASO y ENFOQUE PARA EL CLÍNICO (RUIZ TALERO PAULA ANDREA, VALENCIA-MEJÍA MARGARITA ROSA, RONDÓN-CARVAJAL JULIÁN FELIPE, CONTRERAS KATEIR MARIE)
R-21 SÍNDROME ESCLERODERMIFORME COMO MANIFESTACIÓN PARANEOPLÁSICA DE CÁNCER DE PRÓSTATA (RONDÓN-CARVAJAL JULIÁN FELIPE, REYNA-CARRASCO ÓSCAR ANDRÉS, CUÉLLAR-RÍOS ISABEL CRISTINA, MUÑOZ-VELANDIA OSCAR MAURICIO)
R-22 OLIGOARTRITIS AGUDA REACTIVA y COMPROMISO EXTRAARTICULAR (CASTAÑEDA CAMACHO HÉCTOR ANDRÉS, TORRES BUSTAMANTE ANGELA MARÍA, TORRES BUSTAMANTE MARIANA)
R-23 EMBOLIA PULMONAR COMO PRIMERA MANIFESTACIÓN EN PACIENTE CON SÍNDROME DE KIKUCHI FUJIMOTO (RUEDA GALVIS MYRIAM, BAUTISTA MIER HEIDER)
R-24 MIOSITIS POR CUERPOS DE INCLUSION (HURTADO YESID; CAMPY JUAN; CORTÉS CAMILO)
R-25 DISFUNCIÓN VENTRICULAR IZQUIERDA SECUNDARIA A REACTIVACIÓN DE LUPUS ERITEMATOSO SISTÉMICO (BUSTOS-CLARO MARLON MAURICIO, GARCIA-CONSUEGRA ELIAS ALBERTO, MOLINA-PIMIENTA LUISANA, RAMÍREZ-MESÍAS DIANA CRISTINA.)
R-26 DEDO AZUL COMO MANIFESTACIÓN DE UN CASO GRAVE DE SÍNDROME DE SOBREPOSICIÓN (ALARCÓN-ROBLES PILAR, SALGADO-SÁNCHEZ JUAN CAMILO, MOLINA-PIMIENTA LUISANA)
R-27 ENCEFALOMIELITIS DISEMINADA AGUDA COMO MANIFESTACIÓN PRIMARIA DE LUPUS ERITEMATOSO SISTÉMICO (GUTIÉRREZ CAROL, MORA SERGIO, TOSCANO ANDRÉS)
R-28 BIOPSIA RENAL CONSECUTIVA EN UNA COHORTE DE PACIENTES CON NEFRITIS LÚPICA DEL CARIBE COLOMBIANO (AROCA GUSTAVO, MENDOZA-JAIMES JACKELINE, GONZÁLEZTORRES HENRY, DOMÍNGUEZ-VARGAS ALEX,MARTINEZ ÁLVARO, CADENA BONFANTI ANDRÉS)
R-29 NEUMOMEDIASTINO ESPONTANEO y DERMATOMIOSITIS (SUPELANO MARIO, ENRIQUE PRIETO, AGATÓN CATALINA, NAVARRETE LINDA, CUINEME SANDRA)
R-30 ENCEFALOPATIA POSTERIOR REVERSIBLE SECUNDARIO A NEUROLUPUS UN DIAGNÓSTICO INUSUAL (MORA JAVIER MAURICIO, OVIEDO PABLO, CABRA ANDREA, FUENTES CARLOS, PRIETO JAVIER, CUERVO JESSICA, FLECHAS JOHN)
R-31 INTOXICACION POR LEVAMIZOL: UNA CAUSA DE VASCULOPATIA EN CONSUMIDORES DE COCAINA (CASTELLANOS-DE LA HOZ JUAN, NARANJO JULIÁN, AGUDELO CARLOS, ARAGÓN DIANA)
R-32 SINDROME DE FELTY y PIODERMA (MARTÍNEZ DIEGO, ECHEVERRY TATIANA, RIAÑO CATALINA, ALVARADO LINA, VILLANUEVA JULIANA)
R-33 PANUVEÍTIS EN EL CONTEXTO DEL SÍNDROME DE VOGTKOyANAGI-HARADA (ÁLVAREZ-PERDOMO LUIS CARLOS, PERDOMO-QUINTERO DANIELA, GIRÓN- CÁRDENAS CAMILA, GONZALEZ- AVILÉS CATALINA)
R-34 TAXONOMÍA DE LAS ENFERMEDADES REUMÁTICAS AUTOINMUNES BASADA EN LA POLIAUTOIMMUNIDAD (MOLANO-GONZÁLEZ NICOLAS, ROJAS MANUEL, RODRÍGUEZ YHOJAN, PACHECO YOVANA, MONSALVE DIANA M., ACOSTAAMPUDIA YENY, RODRÍGUEZ-JIMENEZ MÓNICA, MANTILLA RUBÉN D., RAMÍREZ-SANTANA CAROLINA, ANAYA JUAN-MANUEL)
R-35 ENFERMEDAD DE STILL: UN RETO DIAGNÓSTICO y TERAPEÚTICO (ARDILA BÁEZ MANUEL, SANDOVAL JENNIFER, TAPIAS ELSA, BERNAL EDGAR)
R-36 HEMOGLOBINURIA PAROXÍSTICA NOCTURNA CON ESQUISTOCITOS EN EL FROTIS DE SANGRE PERIFÉRICA (ALARCÓN CLARA, ÁLVAREZ LUIS CARLOS, DOMÍNGUEZ JUAN DIEGO, ROMÁN ADRIANA, PUENTES MARÍA ELCY, JIMENEZ JAIME MARTIN)
2
Vranich, Stanko B. "Luis Carlos López visto por su hermano". Revista Iberoamericana 52, n.º 135 (22 de setembro de 1986): 691–702. http://dx.doi.org/10.5195/reviberoamer.1986.4235.
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Contra a Discriminação Racial, Movimento Negro Unificado. "Movimento Negro Unificado Contra a Discriminação Racial (1982)". InSURgência: revista de direitos e movimentos sociais 3, n.º 2 (14 de abril de 2018): 532–36. http://dx.doi.org/10.26512/insurgncia.v3i2.19774.
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Vilar Sánchez, Juan Antonio. "Dos procesos dinásticos paralelos en la década de 1520 Carlos V y su hermano Fernando I". Hispania 60, n.º 206 (5 de março de 2019): 835. http://dx.doi.org/10.3989/hispania.2000.v60.i206.538.
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Hasta 1520 Carlos había cumplimentado la primera etapa en su proceso dinástico, la obtención de casi toda su herencia patrimonial. La segunda etapa, la conservación de tan vasto imperio, se mostró harto difícil y por ello, desde 1522, Carlos fue cediendo partes de su patrimonio y de sus derechos a su hermano Fernando, que a su sombra, fue creando su propio patrimonio dinástico, la Alta Alemania-Austria, las coronas hereditarias de Bohemia y Hungría y finalmente los derechos sobre el Imperio. La tercera etapa del proceso dinástico, la fijación de un heredero en que dejar asegurado todo el proceso, estaba ya también muy clara desde 1525. Carlos había decidido que necesitaba de dos herederos, un hijo propio para sus tierras patrimoniales, y su hermano Fernando para sus derechos sobre el Imperio. La consecución de ambos fines, sin fijar cual era el más importante de los dos, siguió un único camino con dos metas diferentes. Fundamental en esta tercera etapa dinástica fue el proceso de preparación de la boda imperial, su realización en Sevilla, el embarazo en Granada, y el nacimiento en 1527 del heredero en Valladolid. La meta que parecía ser la principal a lo largo de todo ese proceso, la unción y coronación imperial en Roma y la elección de Fernando como rey de Romanos, fue quedando postergada por los acontecimientos y sólo se alcanzó en 1530 y 1531, cerrando la tercera etapa en la carrera dinástica de Carlos V.
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Gonzalez-Gallardo, Carlos Luis, Noé Arjona, Lorena Álvarez-Contreras e Minerva Guerra-Balcázar. "Correction: Electrochemical creatinine detection for advanced point-of-care sensing devices: a review". RSC Advances 12, n.º 49 (2022): 31890. http://dx.doi.org/10.1039/d2ra90109a.
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Correction for ‘Electrochemical creatinine detection for advanced point-of-care sensing devices: a review’ by Carlos Luis Gonzalez-Gallardo et al., RSC Adv., 2022, 12, 30785–30802, https://doi.org/10.1039/D2RA04479J.
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Villegas Páucar, Samuel Alcides. "Las cortes de Cádiz y la cuestión indígena, 1808-1814". Revista de antropología, n.º 5 (31 de dezembro de 2007): 199–220. http://dx.doi.org/10.15381/antropologia.v0i5.20000.
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Xavier-Guerra señala que, el primero de los acontecimientos “que marca de una manera definitiva a todo el mundo hispánico”, es la abdicación de Bayona1, cuando en 1808, Fernando VII, presionado por Napoleón, abdica la corona a favor de su padre Carlos IV, éste a su vez se lo entrega a Napoleón, quien luego termina dejándoselo a su hermano José.
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Zalama, Miguel Ángel. "Los tapices de la Batalla de Pavía. De María de Hungría al príncipe don Carlos". Además de. Revista on line de artes decorativas y diseño, n.º 9 (13 de outubro de 2023): 137–59. http://dx.doi.org/10.46255/add.2023.9.134.
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La serie de tapices de la Batalla de Pavía perteneció a María de Hungría. La reina abandonó los Países Bajos junto con su hermano, el emperador Carlos V, para trasladarse a España, donde falleció en 1558. La colgadura pasó a manos de su sobrino-nieto el príncipe Don Carlos, hijo de Felipe II. Sin embargo, no tuvo demasiado tiempo los tapices, pues los intercambió, que no regaló, con el marqués de Pescara por un anillo, una medalla y sesenta y seis botones de oro. Las razones de este desigual cambio y por qué Felipe II permitió que los paños abandonaran España es algo que permanece sin resolver.
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Tabares Ochoa, Catalina María. "Análisis de un discurso antirracista, espontáneo y callejero. El caso de Carlos Alberto Angulo Góngora y su intervención pública en el centro de Bogotá". Boletín de Antropología 33, n.º 56 (4 de setembro de 2018): 226–48. http://dx.doi.org/10.17533/udea.boan.v33n56a11.
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El 15 de septiembre de 2015, en el centro de Bogotá, Colombia, Carlos Alberto Angulo Góngora, quien se dirigía hacia su trabajo con su hermano menor, fue abordado por dos policías entre muchos otros transeúntes. “Negro, una requisa”, le dijo uno de los policías. Tras este hecho, la reacción de Carlos Alberto consistió en el pronunciamiento de un discurso claramente antirracista que quedó plasmado en un video subido a YouTube y que se tornó viral en Colombia. El presente artículo pretende analizar detallada y sistemáticamente el corpus discursivo de este episodio a partir de una perspectiva de análisis crítico del discurso en la que se incluyen conceptos propios de la sociología de la vida cotidiana.
9
Gozalbes García, Helena, e Carlos Gozalbes Cravioto. "Enrique Gozalbes Cravioto (1957-2018), un historiador de todos y para todos". Vínculos de Historia. Revista del Departamento de Historia de la Universidad de Castilla-La Mancha, n.º 8 (20 de junho de 2019): 411. http://dx.doi.org/10.18239/vdh_2019.08.21.
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El 12 de julio de 2018 fallecía nuestro compañero y amigo Enrique Gozalbes. Desde Vínculos de Historia, a cuyo Consejo de Redacción perteneció Enrique,hemos querido que tenga un lugar en la revista no solo nuestro pesar sino también nuestro más sincero reconocimiento a su importante labor como historiador. Nadie mejor que su hija Helena y su hermano Carlos, compañeros de profesión, para redactar la semblanza vital e historiográfica que sigue a continuación.
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Espaço Aberto, Revista. "Outros professores que passaram pelo PPGG/UFRJ". Espaço Aberto 12, n.º 2 (9 de dezembro de 2022): 221–27. http://dx.doi.org/10.36403/espacoaberto.2022.55322.
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Prof. Milton Santos (1926-2001)Profa Maria Luiza Fernandes PereiraProfa Leila Christina Duarte DiasProf. Carlos Minc BaumfeldProfa. Irene Ester Gonzalez GarayProf. Elmo da Silva Amador (1943/2010)Profa. Ana Clara Torres Ribeiro (1944-2011)Prof. João José Bigarella (1923-2016)Prof. Hélio Monteiro Penha (1949-2009)Prof. Rafael StraforiniProf. Antônio Paulo de FariaProf. Eduardo José Pereira Maia
11
Infante, Ulisses. ""O carioca passava a vida musicando" ou o carioca Murilo Mendes e a Música Popular Urbana". Teresa, n.º 4-5 (8 de dezembro de 2003): 228. http://dx.doi.org/10.11606/issn.2447-8997.teresa.2003.116385.
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Resumo Este ensaio parte da constatação de que o lundu, o maxixe e o samba são referências frequentes nos primeiros livros de poesia de Murilo Mendes — Poemas, Bumba-meu-poeta e História do Brasil. Tais referências são a parte mais visível de uma reflexão densa sobre a constituição e a importância da música popular urbana no mosaico das manifestações culturais brasileiras. O que Murilo Mendes pensou sobre a música das ruas pode ser proveitosamente relacionado com a contribuição recente de Hermano Vianna, Carlos Sandroni e André Gardel ao tema
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Andreu Candela, Irene, e Cayetano Mas Galvañ. "La correspondencia de Carlos III como fuente para el estudio climático (1759-1782)". Revista de Historia Moderna, n.º 39 (1 de outubro de 2021): 99. http://dx.doi.org/10.14198/rhm2021.39.04.
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El presente artículo analiza la información climática contenida en la correspondencia del monarca Carlos III con tres de sus principales corresponsales italianos: su hermano Felipe de Parma, el ministro napolitano Bernardo Tanucci y el príncipe de San Nicandro. La homogeneidad y la continuidad de los comentarios del rey han permitido crear una serie de casi un cuarto de siglo que contribuye a conocer el comportamiento del clima durante las décadas de 1760 y 1770, coincidentes con el inicio de la Anomalía Maldá. Con el fin de cuantificar y tratar serialmente una información que es de naturaleza subjetiva, se han aplicado y comparado los resultados que ofrecen dos diferentes métodos (sistemas de índices y análisis de contenido).
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Sanzsalazar, Jahel. "Los hermanos Estuardo y los Wautier. Retratos de una familia real en el exilio". Philostrato. Revista de Historia y Arte, n.º 9 (25 de junho de 2021): 29–59. http://dx.doi.org/10.25293/philostrato.2021.02.
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El presente artículo examina la relación de los hermanos pintores del siglo XVII, Michaelina (Mons, 1604–Bruselas, 1689) y Charles Wautier (Mons, 1609– Bruselas, 1703), con los tres hijos mayores de Carlos I de Inglaterra, en el contexto previo a la restauración de la soberanía de los Estuardo en Gran Bretaña, mientras estaban en Bruselas, en el exilio. Junto al ya conocido Retrato de James, duque de York (Londres, 1633–1701), por Charles Wautier, se somete a investigación un anónimo retrato de dama vestida de rojo que se identifica con Mary Stuart, Princesa Real de Inglaterra y Princesa de Orange (Londres, 1631–1660), quien habría posado para la hermana de Charles, Michaelina, a principios de 1660, cuando es posible localizarla en Bruselas, pocos meses antes de su temprana muerte. El significativo hallazgo refuerza la relación de los Wautier con los Estuardo y nos invita a considerar un retrato del hermano mayor y pronto rey, Carlos II (Londres, 1630–1685), realizado en las mismas circunstancias.
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Schlickers, Sabine. "La violencia y lo abyecto en Bajo este sol tremendo (2009), de Carlos Busqued, y El otro hermano (2017), de Israel Adrián Caetano". Trasvases entre la Literatura y el Cine, n.º 3 (29 de setembro de 2021): 181–94. http://dx.doi.org/10.24310/trasvasestlc.vi3.10629.
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El director argentino Israel Adrián Caetano realizó con El otro hermano (2017) una adaptación cinematográfica muy lograda de la novela Bajo este sol tremendo de Carlos Busqued (2009) en la que el pasado de la dictadura se vincula con el presente narrativo a través de la violencia de un ex militar de la fuerza aérea. El único afán de este protagonista llamado Duarte es la guita, que adquiere con secuestros y actos de corrupción, que forma parte de la violencia sistémica. En la película, Duarte es un tipo sórdido, todo en él es horrible y a la vez extrañamente atrayente, por lo que se correlaciona con la noción de lo abyecto de Kristeva (1982). Su representación se distingue de la de los militares de la dictadura en el «cine de desaparecidos», como se demuestra con un breve análisis de Garage Olimpo (1999), de Marco Bechis. Concluyo que la personalidad abyecta, contradictoria de Duarte, caracteriza asimismo la ambigüedad de la violencia representada en El otro hermano, que provoca los mismos efectos de atracción y rechazo en el espectador implícito y lo llevan a una reflexión mediática y genérica.
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Muñoz Figueroa, Jorge Antonio. "Una angustia compartida. Análisis de la voz narrativa en Mi hermano Carlos de Jorge López Páez". CONNOTAS. REVISTA DE CRÍTICA Y TEORÍA LITERARIAS, n.º 13 (1 de janeiro de 2013): 97–115. http://dx.doi.org/10.36798/critlit.v0i13.110.
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El presente trabajo revisa las técnicas narrativas empleadas por Jorge López Páez (1922) en la novela Mi hermano Carlos (1965), relato donde el autor veracruzano consolida su estilo y uno de los temas más importantes de su universo ficcional: la infancia. Las implicaciones de elegir a niños como figuras centrales se perciben claramente en el tipo de focalización y la modulación entre la narración consonante y la disonante, lo que da como resultado infantes con discursos propios y no simples vehículos de pensamientos adultos. Pero más aún: narradores que regresan a sus recuerdos para enfrentar, una vez más, los sentimientos que vivieron como personajes.
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Salinas, Martín. "In the red corner. The marxism of José Carlos Mariátegui, de Mike Gonzalez". Inter Litteras, n.º 3 (1 de outubro de 2021): 246–47. http://dx.doi.org/10.34096/interlitteras.n3.10753.
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RUBBO, DENI ALFARO. "Mariátegui em debate: fantasmas marxistas e horizontes críticos". Estudos Avançados 37, n.º 107 (janeiro de 2023): 239–52. http://dx.doi.org/10.1590/s0103-4014.2023.37107.014.
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RESUMO Este ensaio tem como objetivo fazer uma avaliação crítica do livro In the red corner: The marxism of José Carlos Mariátegui, do historiador Mike Gonzalez, recém-publicado nos Estados Unidos. Através de uma incursão neste trabalho, que consiste em uma biografia política sobre as diversas etapas da trajetória e do pensamento de Mariátegui, é possível observar seus alcances e lacunas a partir da comparação com outros trabalhos produzidos. Oportuniza também esboçar alguns desafios sobre questões metodológicas e políticas tendo em vista pesquisas mariateguianas futuras.
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Delgado-García, Guillermo, Carolina Rodríguez-Návarez e Bruno Estañol. "Pierrot doctor (1898) de Julio Ruelas (1870-1907)". Archivos de Neurociencias 23, n.º 2 (17 de maio de 2020): 36–41. http://dx.doi.org/10.31157/an.v23i2.9.
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El dibujante, grabador, pintor e ilustrador mexicano Julio Ruelas (1870-1907) está íntimamente ligado al modernismo, nombre con el que se conoció al simbolismo en nuestro país. Ruelas expuso por primera vez su óleo Pierrot doctor (1898) en la XXIII Exposición Nacional de Bellas Artes en la Academia de San Carlos. El tema y escenario de esta pintura están influenciados por la obra del escritor Bernardo Couto Castillo (1879-1901). El pintor utilizó como modelo a su hermano, quien años luego se graduaría como médico cirujano con la tesis La cura radical de la hernia inguinal (1907). A través de una de las dos ilustraciones anatómicas reproducidas por Ruelas en su lienzo, fue posible identificar el libro de medicina que está leyendo el Pierrot doctor: el Traité de Paul Tillaux (1834-1904), profesor de clínica quirúrgica en la Facultad de Medicina de París. En el libro que sostiene el Pierrot doctor es posible observar la sustancia gris en azul, el cordón de Goll y el fascículo piramidal directo en rojo, y el fascículo cerebeloso directo igualmente en azul. En el germen de este Pierrot doctor confluyeron diversos ejes, entre estos, las afinidades espirituales del pintor, el influjo ejercido por Couto y la imagen del hermano estudiante de medicina y posteriormente médico.
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Delgado-García, Guillermo, Carolina Rodríguez-Návarez e Bruno Estañol. "Pierrot doctor (1898) de Julio Ruelas (1870-1907)". Archivos de Neurociencias 23, n.º 2 (17 de maio de 2020): 36–41. http://dx.doi.org/10.31157/archneurosciencesmex.v23i2.9.
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El dibujante, grabador, pintor e ilustrador mexicano Julio Ruelas (1870-1907) está íntimamente ligado al modernismo, nombre con el que se conoció al simbolismo en nuestro país. Ruelas expuso por primera vez su óleo Pierrot doctor (1898) en la XXIII Exposición Nacional de Bellas Artes en la Academia de San Carlos. El tema y escenario de esta pintura están influenciados por la obra del escritor Bernardo Couto Castillo (1879-1901). El pintor utilizó como modelo a su hermano, quien años luego se graduaría como médico cirujano con la tesis La cura radical de la hernia inguinal (1907). A través de una de las dos ilustraciones anatómicas reproducidas por Ruelas en su lienzo, fue posible identificar el libro de medicina que está leyendo el Pierrot doctor: el Traité de Paul Tillaux (1834-1904), profesor de clínica quirúrgica en la Facultad de Medicina de París. En el libro que sostiene el Pierrot doctor es posible observar la sustancia gris en azul, el cordón de Goll y el fascículo piramidal directo en rojo, y el fascículo cerebeloso directo igualmente en azul. En el germen de este Pierrot doctor confluyeron diversos ejes, entre estos, las afinidades espirituales del pintor, el influjo ejercido por Couto y la imagen del hermano estudiante de medicina y posteriormente médico.
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Ducange, Jean-Numa, Camila Vergara, Talat Ahmed e Christian Høgsbjerg. "Book Reviews". Theoria 67, n.º 163 (1 de junho de 2020): 106–18. http://dx.doi.org/10.3167/th.2020.6716305.
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The Complete Works of Rosa Luxemburg. Volume III. Political Writings, 1: On Revolution 1893–1905, by Peter Hudis, Axel Fair-Schulz and William A. Pelz (eds). London: Verso, 2019. 592 pp.In the Red Corner: The Marxism of José Carlos Mariátegui by Mike Gonzalez. Chicago: Haymarket Books, 2019. 231 pp.Indigenous Vanguards: Education, National Liberation and the Limits of Modernism, by Ben Conisbee Baer. New York: Columbia University Press, 2019. 384 pp.Here to Stay – Here to Fight: A Race Today Anthology, by Paul Field, Robin Bunce, Leila Hassan and Margaret Peacock (eds). London: Pluto Press, 2019. 304 pp.
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Setton, Roman Pablo. "El otro hermano, animalidad, razón utilitaria y política como pilares constructivos del noir en la actualidad". Alea: Estudos Neolatinos 20, n.º 1 (janeiro de 2018): 110–24. http://dx.doi.org/10.1590/1517-106x/2018201110124.
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Resumen: El siguiente artículo analiza una de las producciones audiovisuales argentinas más importantes del año 2017, la película El otro hermano, de Adrián Caetano, transposición cinematográfica de la novela Bajo este sol tremendo, de Carlos Busqued. Intentamos mostrar de qué modo esta nueva producción de Caetano se distancia de sus producciones anteriores pertenecientes al género negro (Un oso rojo, Bolivia, Tumberos), a partir de la construcción de un mundo que se puede emparentar sin dificultad con la concepción deleuzeana de la imagen-pulsión, un mundo que ya no deja lugar para los códigos de las películas previas del director. Asimismo, tratamos de extender la tesis sobre la película y mostrar que la razón utilitaria y la animalidad aparecen como determinantes contemporáneas fundamentales del film noir en la actualidad.
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Vetter, María Alicia. "Book Review: In the Red Corner: The Marxism of José Carlos Mariátegui by Gonzalez, M." Adult Education Quarterly 71, n.º 3 (1 de fevereiro de 2021): NP1—NP3. http://dx.doi.org/10.1177/0741713621991496.
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Da Silva, Arlene Batista, e Ana Carla Soares De Oliveira. "BATUCADA NO MORRO: A PRESENÇA DA RODA DE SAMBA NO CONTO ANA DAVENGA, DA AUTORA CONCEIÇÃO EVARISTO". Estudos Linguísticos e Literários, n.º 70 (11 de dezembro de 2021): 85–106. http://dx.doi.org/10.9771/ell.i70.44104.
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Este artigo tem como objetivo levantar discussões acerca da presença da roda de samba no conto Ana Davenga (1995), de Conceição Evaristo, a partir dos aspectos da tradição histórica. Inicialmente, reconhece-se a importância do samba como forma de divertimento para as comunidades afro-brasileiras, tendo em vista as influências culturais oriundas da África. Assim, busca-se apoio nos referenciais teóricos de Hermano Vianna na obra O Mistério do Samba (1995), Feitiço Decente (2012) de Carlos Sandroni, O terreiro e a Cidade (2002), de Muniz Sodré, entre outros. No conto Ana Davenga, a roda de samba compõe o espaço da narrativa como o lugar de divertimento e alegria ao passo das batucadas. Ancorado em uma análise literária, este artigo trouxe resultados reflexivos sobre as relações interartes – literatura e música, com destaque para o legado deixado pelos povos em nossa tradição musical.
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Mansilla, Silvina Luz. "Un aporte de Carlos Guastavino y Lima Quintana al mundo de la Nueva Canción argentina". Per Musi, n.º 23 (junho de 2011): 19–27. http://dx.doi.org/10.1590/s1517-75992011000100003.
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El artículo se refiere a la canción Hermano compuesta por el músico Carlos Guastavino sobre una poesía de Hamlet Lima Quintana. Dedicada al editor Rómulo Lagos, fue grabada por Mercedes Sosa en 1966. Incluida como pista inicial del disco de la cantante tucumana al cual le dio su nombre, la canción constituye una evidencia de la simpatía del compositor con los postulados centrales del Nuevo Cancionero argentino. El trabajo comprende una aproximación a la temática del poema, el análisis musical de la partitura, la puesta en contexto de las circunstancias de composición y difusión y la descripción de la versión grabada por Mercedes Sosa. Aplicando la noción "mundos del arte" de Howard BECKER (1982), se interpreta la red de personas ligadas a la editorial Lagos como un tejido cooperativo que funcionó con eficacia hasta mediados de la década de 1970. Un esbozo del contexto posterior, signado por la censura, permite inferir algunos factores que incidieron en el quiebre de esa red de colaboraciones. Aunque respecto de Guastavino, se habla aquí de vinculación y no de pertenencia.
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Ferrer del Río, Estefanía. "Successio ab intestato: A propósito de la muerte de Rodrigo de Mendoza, I Marqués del Cenete". Revista de Historia Moderna. Anales de la Universidad de Alicante, n.º 35 (14 de novembro de 2017): 467. http://dx.doi.org/10.14198/rhm2017.35.14.
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La muerte de Rodrigo de Mendoza, I Marqués del Cenete, sin testamento se vio envuelta de la incertidumbre propia del fallecimiento de un noble con un cuantioso patrimonio heredado en gran parte de su padre, el gran cardenal de España, sin especificar ni repartir y con tres hijas menores huérfanas sin un albacea designado por él. El gobernador general de Valencia, Lluís de Cabanyelles, del círculo más íntimo del marqués durante su estancia en la ciudad del Turia, junto a otros partícipes y testigos, llevó a cabo el proceso de inventariado de todos sus bienes cuatro días después de su defunción, apelando, asimismo, al emperador Carlos V para que confirmase al virrey del Reino de Valencia y hermano del Marqués, Diego Hurtado de Mendoza, como tutor de sus sobrinas. El objetivo del trabajo es esclarecer el complejo proceso seguido para la correcta transmisión de los bienes de un destacado noble castellano afincado en Valencia fallecido ab intestato.
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Residentes, Residentes. "Nefrología". Acta Médica Colombiana 43, n.º 2S (24 de junho de 2019): 188–97. http://dx.doi.org/10.36104/amc.2018.1402.
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NF-1 MANEJO MULTIDIMENSIONAL DE CALCIFILAXIS URÉMICA (PATIÑO GIRALDO SANTIAGO)
NF-2 SÍNDROME PULMON RIÑON (RUBIANO WENDY, SÁENZ OSCAR)
NF-3 PRESENTACIÓN ATÍPICA DE NEFROPATÍA POR IGA (MUÑOZ OSCAR, ÁVILA VANEZA, GONZALEZ IVAN)
NF-4 PERITONITIS ASOCIADA A DIÁLISIS PERITONEAL POR MYCOBACTERIUM FORTUITUM (SANDOVAL JENNIFER, BERNAL EDGAR, TAPIAS ELSA, ARDILA MANUEL)
NF-5 HEMOSIDEROSIS EN PACIENTES TRATADOS PARA ANEMIA FERROPENICA EN DIÁLISIS (AGUDELO CARLOS, NAVARRO ALBERTO, YUCUMÁ SAMUEL, WANCJER BENJAMÍN, MOLANO ALEJANDRA)
NF-6 FALLA RENAL AGUDA POR ACTIvACIÓN DE LA vÍA ALTERNA DEL COMPLEMENTO (CASTAÑEDA CAMACHO HÉCTOR ANDRÉS, PINILLA QUINTERO LADY SAMARA, HERNÁNDEZ SIERRA ASTRID PATRICIA)
NF-7 LESION RENAL AGUDA SECUNDARIA A RABDOMIOLISIS POR SALMONELLA GUARÍN GLORIA, ECHEVERRI JORGE, LARRARTE CAROLINA, SUÁREZ WILSON, FIGUEROA CHRISTIAN
NF-8 CORRELACIÓN DE LAS FÓRMULAS DE LA TASA DE FILTRACIÓN GLOMERULAR ESTIMADA CON LA DEPURACIÓN DE CREATININA EN ORINA DE 24 HORAS (VARELA DIANA-CRISTINA, RESTREPO MARY-ALEJANDRA, RUIZ ALEJANDRA, GUARÍN MAYRA, TABARES MABEL, MARTÍNEZ LINA, URIBE MAURICIO)
NF-9 LESIÓN RENAL AGUDA ASOCIADA A PICADURA DE AvISPAS (FIGUEROA CHRISTIAN, LARRARTE CAROLINA, SUAREZ WILSON)
NF-10 SINDROME HEMOLITICO UREMICO ATIPICO Y RETIRO DE ECULIZUMAB, A PROPÓSITO DE UN CASO (ÁLVAREZ PERDOMO LUIS CARLOS, BARRAGÁN LUIS ERNESTO, HERRERA CÉSPEDES CRISTHIAN EMILIO, CUELLAR AZUERO MARÍA ISABEL, PEDRAZA ATAHUALPA PAOLA ANDREA)
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Peattie, Lisa. ": Paraguana: Tradiciones y Cambios en el Habitat de una Region Venezolana . Graziano Gasparini, Carlos Gonzalez B., Luise Margolies." American Anthropologist 89, n.º 4 (dezembro de 1987): 981–82. http://dx.doi.org/10.1525/aa.1987.89.4.02a00480.
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Goeury, Hugo. "Gonzalez, Mike (2019) In the Red Corner: The Marxism of José Carlos Mariátegui, Haymarket Books (Chicago, IL), 231 pp. £12.32 pbk." Bulletin of Latin American Research 40, n.º 2 (abril de 2021): 326–28. http://dx.doi.org/10.1111/blar.13256.
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Agustín-Lacruz, Carmen, e María Jesús García Camón. "Hijas de Pliego, un estudio fotográfico en Pamplona (1924-1934)". Documentación de las Ciencias de la Información 47 (25 de junho de 2024): 55–70. http://dx.doi.org/10.5209/dcin.96052.
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Con el nombre comercial de Hijas de Pliego, Esmeralda, Blanca e Isolina Pliego Soler dirigieron entre 1924 y 1934 el único estudio fotográfico femenino de Pamplona. Heredaron el establecimiento de su padre y formaron parte de la segunda generación de fotógrafos de esta ciudad, adquirieron conocimientos técnicos estéticos en los estudios familiares. Fueron primero ayudantes en el estudio paterno y luego también sus herederas, tras la prematura muerte de su hermano Emilio Carlos Pliego. Contaban 45, 44 y 31 años respectivamente, convivían en el domicilio familiar y estaban solteras. Su gabinete se encontraba en la Plaza del Castillo, 22, junto al Teatro Gayarre. Allí realizaban trabajos de estudio, retratando a la burguesía pamplonesa con técnica impecable y estilo moderno. También colaboraban con los medios de la prensa local y nacional, publicando en ellos retratos y fotonoticias. El objetivo de este trabajo es investigar las trayectorias biográficas y profesionales de María de la Esmeralda Eloísa Leopoldina, (1878 - 1952), Blanca Rufina Isabel (1879 - 1936) e Isolina Jovita, (1892 - 1969) y estudiar su obra fotográfica, tanto de estudio como sus colaboraciones con la prensa local y nacional. La metodología desarrollada ha consistido en el análisis y cotejo de un amplio conjunto de fuentes orales, archivísticas y hemerográficas; la revisión sistemática de fuentes bibliográficas, como anuarios y guías comerciales, tanto regionales como nacionales y el análisis crítico del corpus de obras fotográficas conservadas en instituciones y en colecciones privadas.
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Álava Carrascal, María Eugenia. "Tiempo de ceniza (1961) de Carlos Murciano: entre el compromiso y la renovación del lenguaje en un poeta de Arcos de la Frontera". Enclaves. Revista de Literatura, Música y Artes Escénicas, n.º 1 (2021): 173–95. http://dx.doi.org/10.12795/enclaves.2021.i01.12.
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No fue hasta 1983 cuando Carlos Murciano (Arcos de la Frontera, 1931) se dedicó exclusivamente a la literatura. Su trayectoria literaria es, sin embargo, muy amplia, aunque en este trabajo solo haremos referencia a la lírica. Acumula más de treinta títulos en verso, siendo el primero El alma repartida (1954) y el último Sonetos para ella (Ars Poética, 2018). En 1970 obtuvo el Premio Nacional de Poesía por Este claro silencio, siendo su máximo galardón. Participó en la fundación, junto a su hermano mayor Antonio, de la revista de poesía Alcaraván (1949), fruto de un grupo de amigos gaditanos que conformaron lo que con el tiempo se ha llamado «Escuela de Arcos de la Frontera». Con semejante trayectoria de galardones, de participación en la vida cultural española y de extensa obra poética, sorprende que esté al margen del canon de los poetas del medio siglo tradicionalmente generado a raíz de antologías con afán historicista. Quizás esa exclusión recalcitrante sea una condición compartida por varios poetas andaluces, como a menudo tuvieron que reivindicar desde antologías propias y orientadas hacia Andalucía como tema. Pero, fundamentalmente, su poesía es de corte tremendamente personalista y está atravesada de principio a fin por una tensión irresoluble entre el yo y los otros, entre el tiempo histórico y el tiempo estático de la conciencia y, como tal, es una poesía meditativa que escapa a las catalogaciones estancas y que a menudo sorprende por clara y otras veces por conceptista y esteticista en exceso. Presentaremos una breve trayectoria del recorrido de la obra de Murciano a través de las antologías para detenernos en Tiempo de ceniza (1961). El fin último del trabajo es determinar las claves estéticas de la poesía de Murciano y, en particular, del poemario seleccionado como ejemplo de esa tensión entre compromiso e introspección
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Calla Quispe, Helen Mari Luz. "“Una herida que sigue sangrando” Protestas y masacre en la región Puno de Puno 2022-2023". Revista de Pensamiento Crítico Aymara 5, n.º 1 (31 de dezembro de 2023): 66–81. http://dx.doi.org/10.56736/2023/120.
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El presente articulo aborda sobre la participación y la lucha constante de los hermanos quechuas y aimaras contra el gobierno de Dina Boluarte, contra la represión que se vivió desde el mes de diciembre del 2022 hasta la fecha de hoy. Grande fue la masacre y la tortura que se vivió en la región de Puno, Ayacucho, Arequipa, Cuzco, Andahuaylas y demás regiones, pero más dolor y sufrimiento se vivió en Puno, la muerte de 29 hermanos y más de 100 heridos. Familiares de los fallecidos, niños, vecinos cercanos al aeropuerto de Juliaca, también en las provincias buscan ayuda psicológica por el trauma que vivieron durante los enfrentamientos y peor aún no encuentran justicia hasta el momento. El objetivo es describir y comprender la valentía y la lucha constante dirigida por los hermanos quechuas y aimaras para dar a conocer su clamor, sus derechos, ya no más abusos contra el hermano puneño. Por ello se utiliza el método etnográfico e investigación cualitativa, como resultado obtenemos información de entrevistas a personas afectadas durante los enfrentamientos que nos contaran detalles de cómo se organizaban la población, muchas personas empezaron a recordar a Pedro Vilcapaza, Rita Puma, Carlos Condorena, Bartolina Sisa, que lucharon de igual forma contra los mistis en esos tiempos para hacer valer sus derechos. En conclusión, se pretende mostrar la gran participación de hombres, mujeres quechuas y aimaras unidos por una lucha justa, ya no mas discriminación hacia los hermanos de las comunidades, solo se busca la justicia para los hermanos fallecidos.
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Tereshchuk, A. A. "Comparative Analysis of Two Versions of A Chapter from the History of Charles V by Baron de los Valles". Bulletin of Kemerovo State University 24, n.º 5 (7 de novembro de 2022): 662–68. http://dx.doi.org/10.21603/2078-8975-2022-24-5-662-668.
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This article features two versions of A Chapter from the History of Charles V written by Louis Xavier Auguet de Saint- Sylvain, Baron de los Valles. The original French version was published in 1835, while the Spanish translation appeared 1837. The text describes the background and the start of the First Carlist War in Spain in 1833–1835. The author was a confidant of Don Carlos, and so his book reflected the Carlist perspective. The author believes that the Spanish translation included certain semantic modifications and additions made due to fit the changing political situation. These almost imperceptible modifications were able to change the perception of some military and political figures of the era, e.g., former Minister F. T. Calomarde, Carlist general V. Gonzalez Moreno, Christino general and future Regent B. Espartero, etc. The research objective was to show how Baron de los Valles interpreted the events related to the capture of Villafranca by the Carlists in 1834. This historical episode, later popularized by numerous memoirs and fiction, appeared only in the Spanish version of the book. The account made by the Baron de los Valles differed from the versions of other memoirists, as well as from the official press reports. A Chapter from the History of Charles V by Baron de los Valles has a low value as a historical source, but presents a considerable interest as an example of Carlist propaganda during the war of 1833–1840.
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Martin-Martinez, M. A., S. Castañeda, F. Sánchez-Alonso, C. García Gomez, C. Gonzalez Juanatey, M. A. Belmonte, J. Tornero et al. "OP0002 INCIDENCE OF FIRST CARDIOVASCULAR EVENT IN SPANISH PATIENTS WITH CHRONIC INFLAMMATORY RHEUMATIC DISEASES: PROSPECTIVE DATA FROM THE CARMA PROJECT AFTER 5 YEARS OF FOLLOW-UP". Annals of the Rheumatic Diseases 79, Suppl 1 (junho de 2020): 2.2–2. http://dx.doi.org/10.1136/annrheumdis-2020-eular.4711.
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Objectives:To determine the incidence and risk factors implicated in the development of first cardiovascular (CV) event (CVE) in patients with chronic inflammatory rheumatic diseases (CIRD) attending Spanish rheumatology clinics after 5 years of follow-upMethods:Analysis of data of patients included in an observational prospective study [CARdiovascular in rheuMAtology (CARMA) project] after 5 years of follow-up. The study includes a cohort of 2234 patients with rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA), and another cohort of matched individuals (n=677) without CIRD from 67 hospitals in Spain. Cumulative incidence per 1000 patients of CVE was estimated in both cohorts at 5 years from the start. Weibull proportional hazard model was used to calculate the Hazard Ratio (HR) and 95% confidence intervals (CI) of the risk factors involved in the development of CV events. Losses to follow-up and their causes were also analyzed.Results:The total number patient who completed the follow-up visit at 5 years was 2.382 (81.9%). Fifteen patients died due to CVE and sixty due to non-CVE. The patients with CIRD showed higher cardiovascular cumulative incidence (40.5; 95% CI: 36.2-44.8) than controls (28.3; 95% CI: 21.8-34.8). The higher risk of developing a first CVE during the 5 years of follow-up was seen in patients with AS (HR: 4.60; 95% CI: 1.32-15.99; p=0.02), those with older age (HR:1.09; 95% CI: 1.05-1.13; p<0.001), higher systolic blood pressure (HR: 2.64; 95% CI: 1.32-5.25; p=0.006), and those with longer duration of the rheumatic disease (HR: 1.07; 95% CI: 1.03-1.12; p=0.002). In contrast, woman gender was a protective factor (HR: 0.45; 95% CI: 0.21-0.99; p=0.047).Conclusion:Patients with AS prospectively followed-up at rheumatology outpatient clinics showed higher risk of developing a first CVE than those without CIRD. Besides traditional CV disease risk factors, a longer time course of the disease is a risk factor for the development of CV disease in patients with CIRD.Acknowledgments:This project has been supported by an unrestricted grant from Abbvie, Spain. The design, analysis, interpretation of results and preparation of the manuscript has been done independently of Abbvie.Disclosure of Interests:Maria Auxiliadora Martin-Martinez: None declared, Santos Castañeda: None declared, Fernando Sánchez-Alonso: None declared, Carmen García Gomez: None declared, Carlos Gonzalez Juanatey: None declared, Maria Angeles Belmonte: None declared, Jesús Tornero: None declared, José Santos Rey: None declared, CARMEN OLGA SANCHEZ GONZALEZ: None declared, Estefanía Quesada-Masachs: None declared, MARIA DELPUERTO MORENO GIL: None declared, Tatiana Cobo-Ibáñez: None declared, Jose Antonio Pinto Tasende: None declared, Jesús Babío: None declared, Gemma Bonilla: None declared, Antonio Juan Mas: None declared, Javier Manero: None declared, Montserrat Romera: None declared, Javier Bachiller-Corral: None declared, Eugenio Chamizo Carmona: None declared, Javier Calvo: None declared, Raimon Sanmarti: None declared, Maria Celia Erausquin: None declared, Rosario Garcia de Vicuna Grant/research support from: BMS, Lilly, MSD, Novartis, Roche, Consultant of: Abbvie, Biogen, BMS, Celltrion, Gebro, Lilly, Mylan, Pfizer, Sandoz, Sanofi, Paid instructor for: Lilly, Speakers bureau: BMS, Lilly, Pfizer, Sandoz, Sanofi, Carmen Barbadillo: None declared, Sergio Ros Exposito: None declared, Javier del Pino Grant/research support from: Roche, Bristol, Consultant of: Gedeon, MARIA JOSE GONZALEZ: None declared, José Manuel Pina Salvador: None declared, Javier Llorca: None declared, Miguel A González-Gay Grant/research support from: Pfizer, Abbvie, MSD, Speakers bureau: Pfizer, Abbvie, MSD
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Montero, F., K. Carpio, I. Janta, J. Molina Collada, B. Serrano Benavente, J. Martínez-Barrio, A. Ariza et al. "AB0431 SALIVARY GLAND ULTRASOUND IN CLINICAL PRACTICE". Annals of the Rheumatic Diseases 79, Suppl 1 (junho de 2020): 1514.1–1515. http://dx.doi.org/10.1136/annrheumdis-2020-eular.4678.
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Background:Sjogren’s syndrome (SS) is characterized by lymphocytic infiltration of the exocrine glands and marked B-lymphocytic cell hyperreactivity involving a variety of serum autoantibodies.1Salivary Gland Ultrasound (SGU) is a simple, fast, and well- tolerated examination, wich provides information about glandular structure and has proven to be very useful in the Sjögren Syndrome diagnosis2. A prognostic value has also been proposed due to its posible relationship with lymphomas and extra-glandular manifestations.Objectives:The objective of our study is to evaluate ultrasound results in patients who went through an SGU in clinical practice, its usefulness in the diagnosis of Sjögren’s syndrome and the presence of complications (lymphomas, extra-glandular manifestations or factors related to increased lymphoma risk).Methods:We conducted a retrospective cross-sectional study with review of clinical records that included all those patients coded as SGU in the Ultrasound unit of Rheumatology Department from 2016 to December 2019. Information collected included final diagnosis, laboratory results, clinical manifestations and ultrasound results. We performed an analysis on the frequency of pathological SGU and on the relationship between this lesions in patients with final SS diagnosis and the presence of lymphoma, extra-glandular manifestations and the laboratory values related with increased lymphoma risk (low complement levels, cryoglobulinemia, positive autoimmunity).Results:SGU was performed in 171 patients in four years, 162 women (94.7%). The previous diagnoses, reason for the request and final diagnosis are shown in Table 1. The vast majority of the SGU were normal, only 28 (16,3%) were pathological, 13 with a grade II and 8 with a grade III. In the other 7 patients grading was not available. Of the 28 patients with pathological SGU, none had lymphoma, only 3 had recurrent parotitis and 15 had had extra-glandular manifestations, mainly arthralgia / arthritis (12). Only 1 patient, with rheumatoid arthritis, had had a lymphoma and the SGU was normal. Antibody positivity was frequent in pathological SGU, 16/23 antinuclear antibodies, 13/22 anti-Ro and 9/23 rheumatoid factor. Of the 86 patients without previous diagnosis, 18 were diagnosed with Sjogren syndrome, 9 with pathological SGU and the rest were normal. No patient diagnosed with a dry non-autoimmune syndrome presented pathological SGU.Table 1.Previous diagnoses, reason for request and final diagnoses.Previous diagnoses (n: 171)Reason for request (n: 171)Final diagnosis (n: 78)Without prior diagnosis (n: 86)Dry non- autoinmune syndrome (n: 127)Dry non-autoimmune syndrome (n: 60)Primary Sjögren’s syndrome (n: 11)Primary Sjögren’s syndrome (n: 12)Primary Sjögren’s syndrome (n: 18)Systemic Lupus Erythematosus (n: 9)Lymphoma (n: 0)Secondary Sjögren’s syndrome (n: 0)Rheumatoid arthritis (n: 24)Control (n: 13)Other diagnoses (n: 7)Other diagnoses (n: 18)Other reasons (n: 11)Conclusion:The impact of the SGU is low and its use cannot, for now, displace other methods (e.g. salivary gland biopsy) in the diagnosis of SS. Also our low number of patients with pathological SGU together with the low prevalence of the complications studied (e.g. lymphomas = 1) prevents the expected comparisons.References:[1]Ramos-Casals M, Solans R, Rosas J, et al. Primary Sjogren syndrome in Spain: clinical and immunologic expression in 1010 patients. Medicine (Baltimore) 2008; 87: 210–219.[2]Damjanov N, Milic V, Nieto-Gonzalez JC, et al. Multiobserver Reliability of Ultrasound Assessment of Salivary Glands in Patients with Established Primary Sjogren Syndrome. J Rheumatology 2016; 43: 1858–1863.Disclosure of Interests:Fernando Montero: None declared, Karen Carpio: None declared, Iustina Janta: None declared, Juan Molina Collada: None declared, Belén Serrano Benavente: None declared, Julia Martínez-Barrio Consultant of: UCB Pharma, Alfonso Ariza: None declared, Javier Rivera: None declared, Carlos Gonzalez Consultant of: Gilead, Janssen, Novartis,, Speakers bureau: Abbvie, Celgene, Gilead, Janssen, Novartis, Pfizer, Roche, Indalecio Monteagudo: None declared, Juan Carlos Nieto Speakers bureau: Pfizer, Abbvie, MSD, Novartis, Janssen, Lilly, Nordic Pharma, BMS, Gebro, FAES Farma, Roche, Sanofi
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Clavijo, María Constanza Toquica. "Joanna de San Esteban: perfil hagiográfico de una vida ejemplar en los albores de la Independencia". Análisis, n.º 79 (15 de dezembro de 2011): 103. http://dx.doi.org/10.15332/s0120-8454.2011.0079.05.
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<p>Bajo los parámetros conceptuales de Michel de Certeau, el texto presenta la hagiografía de la monja clarisa Joanna María de San Esteban. La investigación se efectuó en el Archivo Privado del Convento de Santa Clara, donde se encontró la Colección de la vida ejemplar de Joanna de San Esteban, obra inédita de inales del siglo XVIII (1790), escrita por el presbítero Martín Palacios Galán. Una de las preguntas centrales que enfocan esta interpretación de la biografía de Joanna fue la que me permitió ir descubriendo por qué era importante, en ese punto de la línea temporal, narrar un modelo religioso de vida ejempliicante que, como lo comunica el mismo texto hagiográfico, ya estaba entrando en desuso. Nuevos aires aparecen a inales del siglo XVIII en los territorios de ultramar derivados de la Ilustración, de la Revolución Francesa y de las políticas borbónicas de Carlos III, cuyo efecto más contundente en el campo religioso fue la expulsión de los jesuitas, y en el cultural, nuevos textos escriturísticos y pictóricos producidos en la Nueva Granada. También variaron notablemente sus contextos de producción y sus formas de circulación, como se puede observar en la producción de imágenes de la Expedición Botánica y en los textos periodísticos que se comenzaron a publicar. De Joanna de San Esteban (1642 – 1708) también se tiene noticia en la obra De la ejemplar vida y muerte dichosa de doña Francisca Zorrilla, escrita por su padre don Gabriel álvarez de Velasco, cuando habla de su madre, también una mujer sobresaliente. Joanna tuvo un hermano jesuita, el padre Gabriel álvarez de Velasco y Zorrilla. Lo importante para mí en este documento es rastrear cómo y por qué se construye un modelo de sujeto barroco en extinción, y cuál es su función social como documento historiográico. No su “vida real”, que jamás la conoceremos a pesar de conocer su imagen “idealizada” y su desafortunado retrato, realizado por una mano inexperta.</p>
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Simion, Sorina Dora. "La exposición de arte visual novelada por Enrique Vila-Matas". Studia Universitatis Babeș-Bolyai Philologia 66, n.º 4 (17 de dezembro de 2021): 223–38. http://dx.doi.org/10.24193/subbphilo.2021.4.15.
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The Art Exhibition as a Novel by Enrique Vila-Matas. I set out to analyze, using the New Rhetoric methods, the book entitled Cabinet d`amateur, an oblique novel published by the contemporary Spanish writer Enrique Vila-Matas in 2019, at the same time as the opening of an exhibition whose curator he was in the Whitechapel Gallery in east London. Choosing the six visual art works, different in nature, concept, and aesthetics, from the collection of the “laCaixa” Foundation represents an occasion for the writer, led by curiosity, to investigate the works of art and to make a personal, purely subjective selection, on which he reflects in his heterogenic work as a genre: the catalogue of an exhibition, memoirs, essay (auto)biography, the skeleton of an oblique novel of the future. The selected works of art (I.G., the mysterious portrait of a woman by the painter Gerhard Richter; an installation, Petite, by Dominique Gonzalez-Foerster; a videoclip, La lección respiratoria, belonging to the artist Dora García; Milonga, Carlos Pazos’s self-portrait; a detailed scenery, Une poignée de terre, by Miquel Barceló and a photography of Theban by Andreas Gursky, in an overlap of an aerial view with one detailed figure) are included in the text as a starting point for meditations and reflections upon the nature of the art in general, because the metaphor of the literary work, the novel of the future, is precisely the building of Rem Koolhass, the library in Seattle, in which different styles overlap and whose shapes are imprecise, undetermined, incongruent, disharmonic and lacking in logic. Literature, visual arts, music, and architecture are associated, and different figures are used to point out the aesthetic of the negative and the idea that form and content are interchangeable. Keywords: Enrique Vila-Matas, Cabinet d´amateur, an oblique novel, general-rhetoric analysis, the exhibition as a novel, literary biography
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Owen, Gareth I., Nicolle Santander, Gabriel Mingo, Pamela Gonzalez, Valentina George, Nicole Babbitt, Alejandra Espinioza et al. "Abstract 5401: Vasculogenic mimicry: A three-step progress to form lumen-containing and fluid-conducting tubular structures in vitro". Cancer Research 84, n.º 6_Supplement (22 de março de 2024): 5401. http://dx.doi.org/10.1158/1538-7445.am2024-5401.
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Abstract Introduction: Vasculogenic mimicry (VM) is a clinical phenomenon by which cancer cells can form vessel-like structures in an endothelial-free (CD31-) fashion. VM presence in tumors correlates to poor patient prognosis. In our laboratory we have established an in vitro model where cancer cells from either cell lines or primary culture form lumen-lined and fluid-conducting tubular structures when grown on laminin-rich Matrigel over a four-day period. Given the duration of formation and the complexity of these structures, we hypothesize that VM in vitro is a multistep process, where each stage requires spatio-temporal organization of adhesive proteins, stemness and EMT (suggesting the need for epithelial to mesenchymal transition) signaling. Methods: Using our in vitro models, we analyzed by siRNA, immunostaining and live cell imaging with Airyscan the distinct phases and the corresponding spatio-temporal organization of selected proteins. Results: We show that VM in vitro has three distinct phases that are characterized by (1) alignment and migration, (2) contraction, proliferation and bridge formation, and (3) tubular structure closure and lumen formation. These steps require spatio-temporal distribution of ZEB1 and E-cadherin (suggesting gain and loss of epithelial to mesenchymal transition), the presence of Integrin β1 and laminin 111, and the distinct localization of Laminin and CD44. Conclusion: A better characterization of VM may lead to the identification of a clinically useful marker to predict poor patient prognosis and shed light on a druggable pathway to treat this subgroup of aggressive cancer. Citation Format: Gareth I. Owen, Nicolle Santander, Gabriel Mingo, Pamela Gonzalez, Valentina George, Nicole Babbitt, Alejandra Espinioza, Isidora Vega, Cristobal Canales, Carolina Ibañez, Roger Gejman, Juan Carlos Roa, Francisco Nualart, Andrea Ravasio, Cristina Bertocchi. Vasculogenic mimicry: A three-step progress to form lumen-containing and fluid-conducting tubular structures in vitro [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 5401.
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Walsh, Dana, Carlos Gonzalez, Bill Shannon e Ken Blount. "30. Antimicrobial Resistance Genes Are Reduced Following Administration of Investigational Microbiota-based Therapeutic RBX7455 to Individuals with Recurrent clostrioides Difficile Infection". Open Forum Infectious Diseases 7, Supplement_1 (1 de outubro de 2020): S16. http://dx.doi.org/10.1093/ofid/ofaa417.029.
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Abstract Background Antimicrobial resistance (AMR) is a challenge in individuals at risk for recurrent Clostrioides difficile infection (rCDI). Recognizing that AMR bacteria colonize the intestinal microbiota, therapeutic approaches that decolonize the gut of AMR bacteria would be valuable. Herein, we assessed the microbial resistome before and after treatment with RBX7455—a room temperature-stable, orally-administered investigational microbiota-based therapeutic—in a Phase 1 trial for reducing CDI recurrence. Methods This investigator-sponsored trial enrolled 30 rCDI patients in 3 open-label treatment groups (n=10 per group): 1) Four RBX7455 capsules BID for 4 days, 2) Four RBX7455 capsules BID for 2 days, 3) Two RBX7455 capsules BID for 2 days. RBX7455 administration began 48 hours after finishing CDI antibiotics. Participants were asked to submit stool samples at baseline, 1, 7, 28 and 56 days after treatment. These were extracted and sequenced using a shallow shotgun method. Relative taxonomic abundances at the class level and the presence of AMR genes were determined for 148 participant samples and 11 product samples using 90% K-mer sequence coverage based on the MEGARes database. Results Ninety percent of participants met the primary endpoint of no CDI recurrence through 8 weeks after treatment, and participant microbiome compositions became more similar to RBX7455 after treatment. The total AMR counts per participant decreased from before to after treatment (p< .05, mixed effects model), with the pattern of AMRs identified (resistome) becoming more like the RBX7455 resistome (Figure 1). Most notably, AMRs associated with multi-drug, fluoroquinolone, and betalactam resistance decreased from before to after treatment. There was no significant difference among the groups with respect to clinical response or changes in microbiome composition and AMR content. Figure 1 Average total and per-class AMR gene counts in participant samples before and after RBX7455 treatment. Conclusion In a Phase 1 trial of RBX7455 for rCDI, AMR gene content decreased after treatment. This underscores the potential of microbiota-based therapies for decolonizing AMR bacteria from the gut microbiota. Continued clinical evaluation of RBX7455 is underway. Disclosures Dana Walsh, PhD, Rebiotix Inc. (Employee) Carlos Gonzalez, MS, BioRankings, LLC (Employee) Bill Shannon, PhD MBA, BioRankings, LLC (Employee) Ken Blount, PhD, Rebiotix Inc. (Employee)
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Sánchez Trolliet, Ana. "Santiago Medero (compilador), Arquitectura en Marcha 1950-1954. La crítica arquitectónica en el semanario Marcha, Montevideo, Facultad de Arquitectura, Universidad de la República, 2014." Estudios del hábitat 15, n.º 1 (16 de maio de 2017): 020. http://dx.doi.org/10.24215/24226483e020.
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Compilado por Santiago Medero y editado por la editorial de la Universidad de la República, el libro Arquitectura en Marcha, reúne una selección de artículos sobre crítica arquitectónica que fueron publicados en esta consagrada revista uruguaya entre los años 1950 y 1956. La edición en libro de estas notas y editoriales, que constituye un generoso ejemplo de visibilización y puesta en disponibilidad de archivos, supuso un extenso trabajo de transcripción y organización de textos. En efecto, uno de los principales logros de esta compilación lo constituye el hecho de que los artículos publicados originalmente en distintas secciones de crítica dirigidas por los arquitectos Ricardo Saxlund, Leopoldo Carlos Artucio y Ramón Gonzalez Almeida, son presentados en torno a cinco áreas definidas especialmente para esta publicación. En la primera parte, “Fundamentos”, los artículos selecciones vuelven visibles los principios arquitectónicos –afines a los del Movimiento Moderno, la carta de Atenas y los CIAM– a los cuales sus autores adscriben. En la segunda sección dedicada a la “Planificación” se transcriben una serie de textos de temas urbanos que permiten ver la pregnancia que tuvieron los difundidos principios del desarrollismo, el planeamiento y la intervención estatal entre los arquitectos uruguayos en los años cincuenta. La tercera sección, “Crítica de Obras”, selecciona una serie de escritos donde a partir del análisis de distintos edificios proyectados y construidos por reconocidos arquitectos uruguayos se evidencia la preocupación de los redactores por hacer de la arquitectura un objeto de apreciación estética entre legos y profesionales. En “Internacionales”, la cuarta sección, se incluyen artículos que expresan el interés por comparar otros contextos nacionales a fin de contradecir el consenso sobre la excepcionalidad del caso uruguayo y su interpretación como un escenario social y cultural de avanzada en la región. En la última sección, “Resonancias”, se transcriben distintas cartas de lectores donde puede verse las reacciones, en general negativas, que estas columnas despertaban entre quienes leían el semanario. El libro contiene además un pequeño estudio introductorio del autor y un anexo biográfico con énfasis en la vida profesional y, en menor medida, la vida política de los principales redactores de estas columnas.
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Lugowska, Iwona, Carlos Rojas, Alejandro Falcon Gonzalez, Lucia Gonzalez Cortijo, Chih-Hung Hsu, Chia-Jui Yen, Sun Young Rha et al. "Abstract CT129: A multicohort, open-label, phase 2 basket study of the coformulation of vibostolimab with pembrolizumab, with or without other anticancer therapies, in select solid tumors". Cancer Research 82, n.º 12_Supplement (15 de junho de 2022): CT129. http://dx.doi.org/10.1158/1538-7445.am2022-ct129.
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Abstract Background: T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is coexpressed with PD-1 on both CD4+ and CD8+ T cells in tumors. Preclinical models and early clinical data have shown enhanced antitumor activity when an anti-TIGIT antibody is co-administered with an anti-PD-1 antibody. The efficacy and safety of a novel coformulation of the anti-TIGIT antibody vibostolimab and the anti-PD-1 antibody pembrolizumab (vibostolimab/pembrolizumab), alone or in combination with other anticancer therapies, will be investigated in select advanced solid tumors in a multicohort, open-label, phase 2 basket trial (NCT05007106). Trial Design: Key eligibility criteria are histologically or cytologically confirmed advanced (locally recurrent unresectable or metastatic) solid tumor naive to anti-PD-1/PD-L1 therapy (Table 1). Patients will be assigned to treatment randomly (cohort A1) or nonrandomly (cohorts A2-G) by tumor type and biomarker status (Table 1). All patients will be treated until disease progression, unacceptable toxicity, patient/physician decision to withdraw, or 35 cycles of vibostolimab/pembrolizumab or pembrolizumab alone. Primary end points are objective response rate (all cohorts) and progression-free survival (PFS; cohort A1) per RECIST v1.1 by blinded independent central review (cohort A1) or investigator (cohorts A2-G). Secondary end points include PFS per RECIST v1.1 assessed by the investigator (cohorts A2-G), quality of life (cohort A1), and duration of response, overall survival, and safety (all cohorts). Enrollment is ongoing. Table 1. Patient Population and Treatment by Cohort Cohort Patient Population Treatmenta A1b PD-L1-positive (CPS ≥1) cervical cancer that progressed on ≥1 line of therapy Vibostolimab 200 mg/pembrolizumab 200 mg Q3W IV Pembrolizumab 200 mg Q3W IV A2 PD-L1-negative (CPS <1) cervical cancer that progressed on ≥1 line of therapy Vibostolimab 200 mg/pembrolizumab 200 mg Q3W IV B1 dMMR endometrial cancer that progressed after 1 prior systemic, platinum-based chemotherapy Vibostolimab 200 mg/pembrolizumab 200 mg Q3W IV B2 pMMR endometrial cancer that progressed after 1 prior systemic, platinum-based chemotherapy Vibostolimab 200 mg/pembrolizumab 200 mg Q3W IV + lenvatinib 20 mg QD PO C PD-L1-positive (CPS ≥1) head and neck squamous cell carcinoma (previously untreated) Vibostolimab 200 mg/pembrolizumab 200 mg Q3W IV D Biliary tract cancer that progressed after 1 prior systemic therapy Vibostolimab 200 mg/pembrolizumab 200 mg Q3W IV E Esophageal cancer (previously untreated) Vibostolimab 200 mg/pembrolizumab 200 mg Q3W IV + 5-FU 800 mg/m2/day on days 1-5 Q3W IV + cisplatin 80 mg/m2 Q3W IV for ≤6 cycles F Triple-negative breast cancer (previously untreated) Vibostolimab 200 mg/pembrolizumab 200 mg Q3W IV + paclitaxel 90 mg/m2 on days 1, 8, and 15 Q4W IV G Hepatocellular carcinoma (previously untreated) Vibostolimab 200 mg/pembrolizumab 200 mg Q3W IV + lenvatinib 12 mg/8 mg QD PO 5-FU, fluorouracil; CPS, combined positive score; dMRR, mismatch repair-deficient; IV, intravenously; pMRR, mismatch repair-proficient; PO, orally; Q3W, every 3 weeks; Q4W, every 4 weeks; QD, once daily. aAll treatments are ≤35 cycles unless otherwise indicated. bPatients in cohort A1 will be randomly assigned 1:1 to receive one of the 2 treatments; analysis will be stratified by prior bevacizumab use. Citation Format: Iwona Lugowska, Carlos Rojas, Alejandro Falcon Gonzalez, Lucia Gonzalez Cortijo, Chih-Hung Hsu, Chia-Jui Yen, Sun Young Rha, Kan Yonemori, Daneng Li, Ravit Geva, Pamela Salman, Eduardo Yanez Ruiz, Qi Liu, Tanya Keenan, Jane Healy, Mariusz Kwiatkowski. A multicohort, open-label, phase 2 basket study of the coformulation of vibostolimab with pembrolizumab, with or without other anticancer therapies, in select solid tumors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr CT129.
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Orenstein, Robert, Sarah Mische, Sarah Mische, Ken Blount, Ken Blount, Lindy Bancke, Xin Su et al. "LB5. A Long-Time Coming: Final 2-year Analysis of Efficacy, Durability, and Microbiome Changes in a Controlled Open-Label Trial of Investigational Microbiota-Based Drug RBX2660 for Recurrent Clostridioides difficile Infections". Open Forum Infectious Diseases 6, Supplement_2 (outubro de 2019): S994—S995. http://dx.doi.org/10.1093/ofid/ofz415.2488.
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Abstract Background Recurrent Clostridioides difficile infection (rCDI) is an urgent public health threat associated with significant mortality and medical cost. Microbiota therapy is gaining acceptance as a strategy to reduce rCDI recurrence. We present the final 24-month analysis of clinical safety, efficacy, and microbiome restoration from a Phase 2 open-label trial of RBX2660 for prevention of CDI recurrence. Methods Participants with multi-recurrent CDI received <2 doses of RBX2660 delivered via enema 7 days apart in this multicenter, open-label Phase 2 study. Efficacy was defined as the absence of CDI recurrence through 56 days after the last dose and was compared with 8-week recurrence-free rates for a historical control cohort that received standard-of-care antibiotic therapy. Fisher exact test compared the proportion of treatment participants who were CDI-free by age and sex. Durability was defined as continued absence of CDI episodes beyond 8 weeks. Safety and durability assessments occurred at 3, 6, 12, and 24 months. Participant stool samples were collected prior to and for up to 720 days after treatment, and microbiome changes were assessed by shallow shotgun sequencing. Results The efficacy of RBX2660 to prevent rCDI at 8 weeks (78.9%; 112/142) was higher than the CDI-free rate in the historical control group (30.7%, 23/75; P < 0.0001). Age and sex did not impact efficacy. Among participants who achieved treatment success at 8 weeks and were evaluable for long-term durability (n = 95), 8 experienced a new CDI episode by the 24-month follow-up for an overall durability of 91.6%. The safety profile was consistent with previous reports for RBX2660. In total, 503 stool samples from 110 treatment responders were analyzed. Within 7 days of treatment, the relative abundance of Bacteroidia and Clostridia remained shifted higher than pre-treatment levels while Gammaproteobacteria and Bacilli declined sharply after treatment, and these changes persisted to at least 24 months. Conclusion RBX2660, a microbiota-based drug, was safe and efficacious for preventing rCDI with clinical durability to 24 months after treatment, independent of age or sex, and RBX2660 durability associated with durable microbiome shifts from pre-treatment to a healthier composition. Disclosures Robert Orenstein, DO, Rebiotix Inc. (Advisor or Review Panel member), Sarah Mische, PhD, Rebiotix Inc. (Employee), Ken Blount, PhD, Rebiotix Inc. (Employee), Lindy Bancke, PharmD, Rebiotix Inc. (Employee), Xin Su, MD, MSci, Rebiotix Inc. (Employee), Dana Walsh, PhD, Rebiotix Inc. (Employee), Adam Harvey, PhD, Rebiotix Inc. (Employee), Carlos Gonzalez, MS, Rebiotix Inc. (Consultant), Dale N. Gerding, MD, Rebiotix Inc. (Board Member).
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Sritharan, Nithya, Carlos Gutierrez, Isaac Perez-Raya, Jose-Luis Gonzalez-Hernandez, Alyssa Owens, Donnette Dabydeen, Lori Medeiros, Satish Kandlikar e Pradyumna Phatak. "Abstract PO1-07-12: Inverse modeling with surface temperature accurately detects the presence of breast cancer". Cancer Research 84, n.º 9_Supplement (2 de maio de 2024): PO1–07–12—PO1–07–12. http://dx.doi.org/10.1158/1538-7445.sabcs23-po1-07-12.
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Abstract Breast cancer affects over 250,000 women in the United States every year. Patient outcomes including overall survival significantly decline with large sized tumors and nodal involvement on initial presentation. The introduction of mammogram screening has been instrumental in the early detection of cancer. However, it has lower sensitivity in dense breast tissue and limited specificity which leads to unnecessary additional invasive testing. Several methods such as magnetic resonance imaging (MRI), computed tomography (CT) and ultrasound imaging are used as adjunctive methods. However, there is still a need for cost-effective techniques without additional radiation exposure for breast cancer screening for use with mammography. We propose an adjunctive screening method using surface temperature measurements and inverse breast modeling for early detection of breath cancer. Methods: We enrolled patients who presented with mammogram detected breast tumors that were confirmed to be cancerous lesions by biopsy. We used prone position steady state infrared imaging of bilateral breasts to measure surface temperatures and multi-view MRI images to create patient specific 3D breast models. The inverse technique applies Levenberg-Marquard algorithms (LMA) and utilizes commercial software for thermal transport modeling. The inverse technique predicts a heat generation map normalized for baseline surface temperatures to localize the presence of an underlying tumor. Results: A total of 25 breast tumors (diameter range from 5 to 27 mm) from 24 patients were included in the analysis with a median patient age of 67 years. One patient had bilateral breast tumors. Mammogram data showed inclusion of mixed breast tissue composition including dense and extremely dense breast tissue. LMA accurately detected the tumor in all 25 patients with maximum absolute errors of 7 mm in location of the tumor in the breast and 1.78 mm in diameter. The accuracy of detection was not affected by tumor histology which included invasive ductal and lobular carcinomas, ductal and lobular carcinoma in-situ and atypical ductal hyperplasia. No heat sensitive tumors were detected in the 23 contralateral breasts which acted as internal negative controls. Conclusion: Infrared temperature profiles and inverse modeling successfully detected malignant breast tumors with no missed tumors or false positive results and could be used as adjunctive screening along with mammography, especially in patients with dense breast tissue. Citation Format: Nithya Sritharan, Carlos Gutierrez, Isaac Perez-Raya, Jose-Luis Gonzalez-Hernandez, Alyssa Owens, Donnette Dabydeen, Lori Medeiros, Satish Kandlikar, Pradyumna Phatak. Inverse modeling with surface temperature accurately detects the presence of breast cancer [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO1-07-12.
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López Gloria, K., I. Castrejon, L. Trives Folguera, J. C. Nieto, B. Serrano Benavente, J. Martínez-Barrio, J. Rivera et al. "AB0205 PREDICTORS OF ULTRASOUND DETECTED INFLAMMATORY FINDINGS IN PATIENTS WITH INFLAMMATORY ARTHRALGIA". Annals of the Rheumatic Diseases 79, Suppl 1 (junho de 2020): 1402.2–1403. http://dx.doi.org/10.1136/annrheumdis-2020-eular.6332.
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Background:Patients with inflammatory arthralgia (IA) are considered to be at increased risk for progression to RA. US has shown high sensitivity to detect synovitis compared with physical examination. Thus, US is recommended to identify subclinical synovitis in patients without clinical signs of inflammation.Objectives:The objective of our study is to determine the frequency and pattern of US detected inflammatory findings in patients with IA and investigate factors contributing to predict these findings.Methods:An US clinic is scheduled in an academic center running three days every week. A retrospective analysis of our US unit cohort during a period of 6 months was undertaken. Patients with IA and no previous diagnosis of inflammatory arthropathies were included for analysis. Inclusion criteria of IA definition included: severe symptoms presenting in the morning, duration of morning stiffness ≥60 min, symptoms predominantly located in MCP joints and abscense of clinically detected synovitis by the referral rheumatologist. The following routinely collected variables were included in the analysis: demographics, clinical features and laboratory tests. Patients underwent bilateral US examination in GS and PD mode of hands and/or feet according to the European League Against Rheumatism (EULAR) guidelines. The presence of synovitis, tenosynovitis and enthesitis was assessed on a semi quantitative scale (0–3) for Grey Scale(GS)/Power Doppler(PD) or using enthesitis OMERACT definition, respectively. Patients were stratified in two groups based on the presence of US inflammatory findings (synovitis, tenosynovitis or enthesitis with PD signal). First, differences between groups were tested using chi-squared and Student-t tests in the univariate analysis. Second, multivariate logistic regression models were employed to investigate the association between possible predictive factors of US detected inflammatory findings.Results:A total of 57 patients were included in the analysis. Mean age was 55.8±15.2 years, 41 (71.9%) were females, and mean symptoms duration was 11.4±10.4 months (Table 1). A total of 42 (73.7%) patients presented with a polyarticular arthralgia pattern. US inflammatory findings were present in 20 (35.1%) patients (26.3% PD synovitis, 21.1% PD tenosynovitis and 3.5% PD enthesitis). Hands were most commonly involved with PD synovitis at wrists in 19.3% and at MCP in 12.3% of patients (Table 2). For PD tenosynovitis, the flexor MCP 2-5 (5.3%) and compartment IV tenosynovitis (1.8 %) were the most frequent affected locations. Only two patients had PD enthesitis at feet and 6 (10.5%) had erosions in hands or feet at baseline examination. In the univariate analysis, the higher ESR values and the shorter time from symptoms onset were significantly associated with US detected inflammatory findings (p=0.044 and 0.049, respectively). In the multivariate analysis, only ESR values (OR=1,04; 95%CI 1,002-1,078), remained significantly associated with the presence of US inflammatory findings (Table 3).Table 3.Independent predictors of US detected inflammatory findingspOdds ratio95% C.I.LowerUpperESR (mm/h)0.0391.041.0021.078Time (months) from symptoms onset0.10.9240.8411.015Conclusion:PD US inflammatory findings are found in 1 over 3 patients with IA being PD synovitis the most common finding, specially at the wrists and MCP joints. Higher ESR values were significantly associated with the presence of US inflammatory findings. Our data highlights how the use of PD US may be useful to detect subclinical synovitis in patients with IA.Disclosure of Interests:Katerine López Gloria: None declared, Isabel Castrejon: None declared, Laura Trives Folguera Speakers bureau: ROCHE, Juan Carlos Nieto Speakers bureau: Pfizer, Abbvie, MSD, Novartis, Janssen, Lilly, Nordic Pharma, BMS, Gebro, FAES Farma, Roche, Sanofi, Belén Serrano Benavente: None declared, Julia Martínez-Barrio Consultant of: UCB Pharma, Javier Rivera: None declared, Carlos Gonzalez Consultant of: Gilead, Janssen, Novartis,, Speakers bureau: Abbvie, Celgene, Gilead, Janssen, Novartis, Pfizer, Roche, Indalecio Monteagudo: None declared, Jose-Maria Alvaro-Gracia Grant/research support from: Abbvie, Elli-Lilly, MSD, Novartis, Pfizer, Consultant of: Abbvie, BMS, Janssen-Cilag, Elli-Lilly, MSD, Novartis, Pfizer, Sanofi, Tigenix, Roche, UCB, Paid instructor for: Elli-Lilly, Pfizer, Roche, Speakers bureau: Abbvie, BMS, Janssen-Cilag, Elli-Lilly, Gedeon Richter, MSD, Novartis, Pfizer, Sanofi, Tigenix, Roche, UCB, Juan Molina Collada: None declared
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Lozano, Jose F. Muñoz, Diana Cristina Pérez Ibave, Estefania Abundis Marquez, Fernando Alcorta Nuñez, Celia B. Gonzalez Alcorta, Carlos Salazar Mejia, Maria Fernanda Noriega et al. "Abstract P1-08-03: EXPLORATORY ANALYSIS OF A MOBILE APP THAT ADDRESSES RADIOTHERAPY INFORMATIONAL NEEDS FOR BREAST CANCER PATIENTS". Cancer Research 83, n.º 5_Supplement (1 de março de 2023): P1–08–03—P1–08–03. http://dx.doi.org/10.1158/1538-7445.sabcs22-p1-08-03.
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Abstract INTRODUCTION Radiotherapy is an area of medicine that is little known by patients and that requires a long time for the doctor to be able to explain and resolve the doubts that arise in the first consultation, which may cause anxiety and low adherence to treatment recommendations. A mobile app called Canswer was developed to address this problem in a novel way to help patients learn about radiation oncology in their free time. OBJECTIVE Developed a mobile app that provides oncology radiotherapy information to patients. MATERIAL AND METHODS The patients who attended the consultation for the first time were provided with information and obtained verbal consent, later they were provided with the Canswer application on their mobile device, and at the end, a Likert-type perception survey was applied and the Cancer Treatment Survey (CATS), which analyzed the information needs of patients. Anxiety and depression were analyzed through the Hospital Anxiety and Depression Scale (HADS). RESULTS Of the total number of patients recruited, 17 patients from northeast Mexico with breast cancer agreed that the use of the application would be useful to them and were interested in receiving additional information after their first-time radiotherapy consultation from March to June 2022. Average age of respondents was 45 years. A total of 7 patients (41%) had doubts about radiotherapy after consultation. When analyzing their knowledge, only 1 patient identified that radiotherapy works by DNA damage, the rest had wrong information, 14 patients thought that this treatment works by heating the cells; 2 thought that radiation therapy causes cells to burst. 8 patients (47%) understood how teletherapy works and 5 how brachytherapy works (19%). A question was included about the best skin care during breast radiotherapy in which 76% correctly answered that the skin should be washed daily with water and neutral soap, but 24% answered that hydrating creams should be applied just before stepping into the machine. Regarding the duration of the consultation, a total of 10 patients (60%) thought it was too short. 47% felt the limited time of the consultation did not allow an adequate evaluation. 100% of the respondents were satisfied with the information provided about the type of treatment, its benefits, and adverse effects, however, 47% persisted with doubts at the end of the consultation. 47% of patients (n=8) had some level of anxiety with 29% mild, 11% moderate and 6% severe. Incidence of depression was 24% with 18% having mild form and 6% severe. Regarding the information provided by the doctor during the consultation, 8 patients (47%) would like their doctor to have told them more about anxiety and depression, 7 about sexuality concerns (41%), and 6 (35%) about alternative medicine. 79% of patients wanted to know more about the side effects the treatment might cause after their visit, and 71% reported wanting to know more about how to prevent side effects. 66% also reported that they would like more information about how the treatment feels when it begins. DISCUSSION AND CONCLUSION This analysis revealed that most patients have doubts about radiotherapy, even after the information provided in their first consultation. This may be multifactorial but a key factor may be work overload at radiotherapy centers and a consultation of short duration. This application seems to be an effective, easily accessible, free tool that provides the necessary information, even on topics that are difficult to explain in a standard consultation. Important aspects that the app needs to focus on in future updates include side effects and their management, sexuality, nutrition, depression, and alternative medicine. This application also revealed misconceptions that should be routinely addressed, such as skin care during treatment. Link to app: https://www.canswer.info/?page_id=393 Citation Format: Jose F. Muñoz Lozano, Diana Cristina Pérez Ibave, Estefania Abundis Marquez, Fernando Alcorta Nuñez, Celia B. Gonzalez Alcorta, Carlos Salazar Mejia, Maria Fernanda Noriega, Omar Zayas Villanueva, Victor Oyervides Juarez, Larisa M. Renteria Garcia, Adelina Alcorta Garza, Juan Francisco Gonzalez Guerrero, Valeria Luna, David Hernandez, Rafael Piñeiro Retif, Oscar Vidal Gutiérrez. EXPLORATORY ANALYSIS OF A MOBILE APP THAT ADDRESSES RADIOTHERAPY INFORMATIONAL NEEDS FOR BREAST CANCER PATIENTS [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr P1-08-03.
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Lozano, Jose F. Muñoz, Omar Zayas Villanueva, Estefania Abundis Marquez, Fernando Alcorta Nuñez, Maria Fernanda Noriega, Carlos Salazar Mejia, Celia B. Gonzalez Alcorta et al. "Abstract P5-04-09: Analysis of an update to a novel breast cancer screening web-app". Cancer Research 83, n.º 5_Supplement (1 de março de 2023): P5–04–09—P5–04–09. http://dx.doi.org/10.1158/1538-7445.sabcs22-p5-04-09.
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Abstract Introduction A minority of women with breast cancer in Mexico are diagnosed through a screening program with a low rate of national coverage of about 20%, which translates into late diagnosis and worse outcomes. The detection of high-risk groups through easy-access interventions is essential to increase the screening rate. OBJECTIVE To identify and analyze patients at high risk of breast cancer, through a web app specially designed for this purpose. MATERIAL AND METHODS The web app stratified respondents according to breast cancer risk into 4 categories: very high risk (symptomatic), high lifetime risk, average risk (usual screening recommendations), or low risk. The app was programmed to guide patients to a risk-based information page or urge them to seek medical advice if indicated (https://cuccuanl.com/tamiz_mama/). The web app also provided the contact information of our center, or an appointment could also be scheduled within the app. Distribution was made via social media. An upgrade of the app was launched, which expanded the functionality with the inclusion of the Gail model to identify women with a high lifetime risk for developing breast cancer and the option for a simple interpretation of mammographic results. In version 2.0, the patients were divided into 2 populations, the first one which already had a breast imaging test but wished to know what the BIRADS score obtained meant and the other group were those who answered a simple survey similar to the one available on version 1.0, with added questions to calculate the Gail model risk. RESULTS The web app was originally released in October 2021 with a total number of 1,012 women answering the survey. The update was released in June 2022 with 406 new subjects. 281 patients wished for a risk calculation with no prior breast imaging tests and 124 patients already had a breast image diagnosis test that wanted a simple interpretation. Table1 depicts the answers given between both versions. Among the group of patients that had a mammography but had doubts about the result 12.9% (n=16) reported a BIRADS 0, 12.1% (n=15) BIRADS 1, 46% (n=57) BIRADS 2, 14.5% (n=18) BIRADS 3, and 14.4% (n=18) BIRADS 4 or 5. To date 41 patients have booked an appointment at the cancer prevention clinic directly within the webapp for further evaluation. DISCUSSION AND CONCLUSION The changes in the criteria of high risk did not translate into changes in the proportion of patients considered at high lifetime risk of breast cancer, but these changes made might be more specific for subsequent screening and chemoprevention strategies. The app persisted with a high proportion of symptomatic patients. The results of integration of the simple mammography interpretation were surprising, with a high proportion of subjects with indication for a biopsy founded. In the Mexican population there is a significant gap between the screening mammography and the first consultation with a specialist, averaging 113 days from an abnormal screening test to a diagnosis of breast cancer (1), which delays treatment initiation resulting on a worst outcome. These kinds of apps may empower patients to seek earlier consultation if warranted or educate patients on their personal risk for developing cancer so they may have a closer adherence to early detection programs. These results and subsequent updates might help evolve the app into something more akin to a digital navigator for patients. Bibliography 1)Unger-Saldaña K, Cedano Guadiamos M. Delays to diagnosis and barriers to care for breast cancer in Mexico and Peru: a cross sectional study. The Lancet Global Health. 2020 Apr 1;8:S16. Table 1 Results stratified by risk groups between version 1.0 and 2.0 Citation Format: Jose F. Muñoz Lozano, Omar Zayas Villanueva, Estefania Abundis Marquez, Fernando Alcorta Nuñez, Maria Fernanda Noriega, Carlos Salazar Mejia, Celia B. Gonzalez Alcorta, Diana Cristina Pérez Ibave, Victor Oyervides Juarez, Larisa M. Renteria Garcia, Adelina Alcorta Garza, Juan Francisco Gonzalez Guerrero, David Hernandez, Rafael Piñeiro Retif, Oscar Vidal Gutiérrez. Analysis of an update to a novel breast cancer screening web-app [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr P5-04-09.
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Remuzgo-Martínez, S., J. Rueda-Gotor, V. Pulito-Cueto, R. López-Mejías, A. Corrales, L. Lera-Gómez, R. Pérez-Fernández et al. "POS0327 IRISIN: A NEW MARKER OF SUBCLINICAL ATHEROSCLEROSIS, CARDIOVASCULAR RISK AND DISEASE ACTIVITY IN AXIAL SPONDYLOARTHRITIS?" Annals of the Rheumatic Diseases 81, Suppl 1 (23 de maio de 2022): 414.1–415. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1058.
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BackgroundAxial spondyloarthritis (axSpA) is an inflammatory disease with detrimental effects on the health status of the individuals affected by this condition [1]. axSpA patients also exhibit high cardiovascular (CV) risk, mainly due to accelerated atherosclerosis [2]. Interestingly, the adipomyokine irisin was described to play a beneficial role in several physiological and pathophysiological processes such as inflammation, angiogenesis, oxidative stress, as well as lipid and bone metabolism [3]. However, studies on the role of irisin in CV risk in the setting of axSpA or in the pathogenesis of axSpA are limited [4].ObjectivesIn this study we evaluated the role of irisin as a genetic and serological biomarker of subclinical atherosclerosis and CV risk in a large cohort of patients with axSpA. We also assessed its role as a marker of axSpA susceptibility and severity.Methods725 patients who fulfilled the Assessment of SpondyloArthritis international Society classification criteria for axSpA were included in this study [5]. In these patients, the presence of subclinical atherosclerosis (plaques and/or abnormal carotid intima-media thickness values) was assessed by carotid ultrasound. Four irisin polymorphisms (rs16835198 G/T, rs3480 A/G, rs726344 G/A and rs1570569 G/T) were genotyped by TaqMan probes in all the patients and in 656 age, sex and ethnically-matched healthy controls. Additionally, serum irisin levels were determined by ELISA in all the patients. All analyses were performed using STATA v.11.1 statistical software, adjusting for potential confounding factors. The strength of associations is indicated as odds ratios (OR) [95% confidence intervals].ResultsLow levels of serum irisin were linked to the presence of plaques (p=0.002) and with atherogenic index values indicative of an adverse lipid profile (p=0.01). Serum irisin levels also negatively correlated with visual analogue scale (VAS) patient, VAS physician and Bath Ankylosing Spondylitis Metrology Index (BASMI) values (p<0.05). Moreover, the presence of sacroiliitis was related to lower serum irisin levels (p<0.001). Furthermore, the minor alleles of rs3480 (G) and rs1570569 (T) were associated with higher values of Ankylosing Spondylitis Disease Activity Score (ASDAS) in axSpA patients (p≤0.01 in both cases). In this line, the frequency of the minor allele of rs1570569 (T) was higher in patients with ASDAS values >2.1 (indicative of high disease activity) (OR: 1.46 [1.08-1.97], p=0.01), while the minor allele of rs16835198 (T) was less frequent in this group of patients (OR: 0.73 [0.57-0.92], p=0.01).ConclusionLow serum irisin levels could be indicators of the presence of subclinical atherosclerosis, high CV risk and more severe disease in axSpA patients. In addition, irisin may also constitute a genetic biomarker of disease activity in axSpA.References[1]Packham J. Rheumatology (Oxford). 2018;57(6):vi29-vi34.[2]Szabo SM, et al. Arthritis Rheum. 2011;63(11):3294–304.[3]Korta P, et al. Medicina (Kaunas). 2019;55(8):485.[4]Nam B, et al. Ann Rheum Dis. 2020;79:1358.[5]Sieper J, et al. Ann Rheum Dis. 2009;68(2):ii1–44.AcknowledgementsThis work was partially supported by grants from Instituto de Investigación Sanitaria IDIVAL (NVAL17/10), from the `Asociación Cántabra de Reumatología’ awarded to FG. FG and JR-G are beneficiaries of a grant funded by `Instituto de Salud Carlos III´ (ISCIII) (PI20/00059). SR-M is supported by funds of the RETICS Program (RD16/0012/0009) from ISCIII, co-funded by the European Regional Development Fund. VP-C is supported by a pre-doctoral grant from IDIVAL (PREVAL18/01). RL-M is a recipient of a Miguel Servet type I programme fellowship from ISCIII, co-funded by the European Social Fund, `Investing in your future´ (grant CP16/00033).Disclosure of InterestsSara Remuzgo-Martínez: None declared, Javier Rueda-Gotor: None declared, Verónica Pulito-Cueto: None declared, Raquel López-Mejías: None declared, Alfonso Corrales: None declared, Leticia Lera-Gómez: None declared, Raquel Pérez-Fernández: None declared, Virginia Portilla: None declared, Iñigo Gonzalez-Mazon: None declared, Ricardo Blanco Speakers bureau: Abbvie, Pfizer, Roche, Bristol-Myers, Janssen and MSD, Consultant of: Abbvie, Pfizer, Roche, Bristol-Myers, Janssen and MSD, Grant/research support from: Abbvie, MSD and Roche, Rosa Expósito: None declared, Cristina Mata: None declared, Javier Llorca: None declared, Vanessa Hernández-Hernández: None declared, Carlos Rodríguez-Lozano: None declared, Nuria Barbarroja Puerto: None declared, Rafaela Ortega Castro: None declared, Esther F. Vicente-Rabaneda: None declared, Cristina Fernández-Carballido: None declared, Maria Paz Martínez-Vidal: None declared, David Castro-Corredor: None declared, Joaquín Anino-Fernández: None declared, Diana Peiteado: None declared, Chamaida Plasencia: None declared, E Galindez: None declared, María L. García Vivar: None declared, Nuria Vegas-Revenga: None declared, Irati Urionaguena: None declared, Oreste Gualillo: None declared, Juan Carlos Quevedo-Abeledo: None declared, Santos Castañeda: None declared, Iván Ferraz-Amaro: None declared, Miguel A González-Gay Speakers bureau: Abbvie, Pfizer, Roche, Sanofi, Lilly, Celgene, MSD, GSK, Grant/research support from: Abbvie, MSD, Janssen, Roche, Fernanda Genre: None declared
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Tapanes-Castillo, Alexis, Mariacira Di Santi, Abel Sousa, Jonathan M. Brown, Paola M. Gonzalez Rodriguez, Thiago P. Leal, Leticia Saladrigas et al. "Abstract 3827: Schinus terebinthifolius extracts impair migration of BT549 triple negative breast cancer cells in vitro". Cancer Research 83, n.º 7_Supplement (4 de abril de 2023): 3827. http://dx.doi.org/10.1158/1538-7445.am2023-3827.
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Abstract Bark extracts, derived from the Brazilian peppertree (Schinus terebinthifolius) were tested on BT549 triple negative breast cancer cells, a model system for invasive, metastatic cancers. Crude extracts, prepared with a 50% ethanol-50% water solvent, were investigated for cytotoxicity and effects on cell migration in vitro. Extract-treated cells exhibited statistically significant slower migration velocities than untreated control cells. Crude bark extracts, screened at a concentration of 3.15mg/mL in five independent experiments, produced an approximate 80% decrease in average migration velocity (p<0.05 in every experiment). Three independent tetrazolium based MTT cytotoxicity experiments confirmed that cells exposed to the same 3.15 mg/mL crude extract concentrations displayed similar viability as untreated control cells. Interestingly, these data suggest the Brazilian peppertree bark extract harbors bioactivity that impairs BT549 cell migration without cytotoxic side effects. Current experiments aim to discover which bioactive molecules, present in the crude extract, impede cancer cell migration. Silica-based column chromatography was used to separate the crude extract into fractions of increasing polarity. A wet method, which commenced with hexane, followed by dichloromethane, methanol, ethanol, ethyl acetate, and butanol, was employed. Fractions which retained anti-migratory activity were identified. Gas chromatography Mass Spectrometry (GCMS) was performed on crude extracts, samples with strong anti-migratory activity, and samples with weak anti-migratory activity, solubilized with ethanol, methanol, and acetonitrile. Data from two independent, complete sets of experiments, involving column chromatography, cellular assays with fractionated extracts, and GCMS, replicated results. Compounds that were unique to specific samples, as well as compounds that were found in multiples samples were identified. Rstudio software was utilized to organize and visualize data. This work lays down the preliminary foundation for future experiments testing specific purified forms of candidate molecules present in Brazilian peppertree bark extracts for the ability to limit BT549 cancer cell migration in vitro. Furthermore, Western blotting and immunocytochemistry experiments are underway to determine cellular signaling pathways targeted by the extract. Funding was provided by St. Thomas University’s Summer Research Institute and U.S. Dept. of Education STEM grants P03C110190, P031C160161, and P031C210035. Citation Format: Alexis Tapanes-Castillo, Mariacira Di Santi, Abel Sousa, Jonathan M. Brown, Paola M. Gonzalez Rodriguez, Thiago P. Leal, Leticia Saladrigas, Vadym Trokhymchuk, Leonardo M. Soto Chumpitaz, Andrea Peterson, Susana Gutierrez, Rolando J. Petit, Carlos Planchart, Christian Del Corro, Daniela A. Ramos, Valeria Nazaire, Sean Mondesire, Maria Pina. Schinus terebinthifolius extracts impair migration of BT549 triple negative breast cancer cells in vitro. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 3827.
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Caballero Motta, L. R., A. M. Anzola Alfaro, L. A. Torrens Cid, C. Y. Soleto, B. Serrano Benavente, I. Janta, J. Molina Collada et al. "AB0333 CLINICAL AND ULTRASONOGRAPHIC RESPONSE TO SUBCUTANEOUS METHOTREXATE IN EARLY RHEUMATOID ARTHRITIS. PRELIMINARY RESULTS." Annals of the Rheumatic Diseases 79, Suppl 1 (junho de 2020): 1465.2–1465. http://dx.doi.org/10.1136/annrheumdis-2020-eular.6573.
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Background:Metotrexate (MTX) is usually the first line therapy for Rheumatoid Arthritis (RA) because of its favorable efficacy-toxicity ratio. However the exact mechanism and treatment response time in both a clinical and ultrasonographic setting are still uncertain.Objectives:To describe the clinical and ultrasound response to MTX during the first 6 months of treatment in early RA patients who started subcutaneous methotrexate as the first disease-modifying drug (DMARD).Methods:Ongoing prospective cohort of patients with early RA (ACR-EULAR 2010 criteria), over 18 years and starting MTX-SC. Patients had a clinical and ultrasonographic evaluation at baseline, 1, 3 and 6 months. We collected demographic data, C-reactive protein [CRP], erythrocyte sedimentation rate [ESR], rheumatoid factor [FR], anti-citrullinated protein antibody [ACPA]), inflammatory activity indexes (DAS28esr and DAS28crp) and EULAR’s response to treatment (delta value of -1.2 in DAS28 scores). Joints explored with ultrasound were elbows and wrists (radio-carpal and inter-carpal joint) counted as a single joint, 1st-5th metacarpophalangeal (MCF), proximal interphalangeal (IFP), knees, tibio-talar and subtalar joints and 2nd-5th metatarsophalangeal (MTF) joints. Bone erosions were evaluated in 2nd and 5th MCF, styloid, distal ulna and 5th MTF. Synovitis was graduated semi-quantitatively from 0 to 3 (OMERACT) and calculated on B mode and Doppler.Results:35 patients were included (mean age 61.2 years, 65.7% women) with a median of 0.8 (+/-8) months delay to diagnosis. 34 patients (97.1%) started 15mg MTX-SC/weekly. A higher DAS28esr was found in baseline data for the group that had a response by month 1 (DAS28esr baseline 5.5 vs 4.2 p=0.01), no other significant differences were found. During the first month, a significant response was achieved in 13 (41%) patients and remission in 11 (35%) (Table 1). 17 patients have 6thmonth data. 11 (64.7%) have achieved EULAR response compared to baseline(P=0.0005) out of which 7 (54.5%) had already reached it by month 1. A difference in MTX dose (month1 14.8 vs month6 17.1 p=0.003) was found between month 1 and 6, with no differences in disease activity. In the ultrasonographic baseline data; 8 patients (22.9%) had erosions, with a mean of 2,75 erosions/patient (22 of the 280 locations). During the follow up the global rating lowered, with no differences in B mode but significant differences in Doppler at the 6 month mark (Table 2). As of this report, 10 patients (28.5%) had stopped MTX treatment due to lack on response or adverse effects and 8 (22.9%) are waiting 6thmonth evaluation.Table 2.Ultrasound synovitis global rating.BaselineMonth 1P ValueEULAR response013 (41)0.00005MTX Dose mg (SD)14.8 (+/-0.8)14.8 (+/-1.6)1Prednisone Dose mg(SD)5.9 (+/-6.5)2.9 (+/-3)0.02DAS28crp (SD)4.3 (+/-1.5)3,4 (+/-1.4)0.02DAS28esr (SD)(4.8 (+/-1.5)3.7 (+/-1.4)0.006Remission (DAS28<1.2)3(9.6)11(35.5)0.04Table 1.Baseline characteristics of the patients with RA (n=102).BaselineN=351 monthN=313 monthsN=256 monthsN=17B Mode:Median (interquartile range)8 (3.5-12)8 (3-12.5)6 (4-11)5 (2-11)p 0,16Doppler Mode: Median (interquartile range)2 (0.5-6)2 (0-6)2 (0-6)0 (0-2)p 0,005Conclusion:In this cohort half of the patients that responded to treatment had achieved this by month 1. A higher baseline inflammatory profile was related to the response. Little difference is found between month 1 and 6 on clinical data, however ultrasonographic results suggest that at least 6 months are needed for Doppler improvement. Perhaps MTX has a faster effect over joint pain and lowers DAS28 scores requiring longer to completely suppress inflammatory activity.References:[1]Braun, J. et al. Comparison of the clinical efficacy and safety of subcutaneous versus oral administration of methotrexate in patients with active rheumatoid arthritis. Arthritis Rheum 2008Disclosure of Interests:Liz R. Caballero Motta: None declared, Ana Melissa Anzola Alfaro: None declared, Luis A Torrens Cid: None declared, Christian Y Soleto: None declared, Belén Serrano Benavente: None declared, Iustina Janta: None declared, Juan Molina Collada: None declared, Carlos Gonzalez Consultant of: Gilead, Janssen, Novartis,, Speakers bureau: Abbvie, Celgene, Gilead, Janssen, Novartis, Pfizer, Roche, Indalecio Monteagudo: None declared, Jose Maria Alvaro Gracia: None declared, Juan Carlos Nieto Speakers bureau: Pfizer, Abbvie, MSD, Novartis, Janssen, Lilly, Nordic Pharma, BMS, Gebro, FAES Farma, Roche, Sanofi
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Molina Collada, J., M. Pérez, I. Castrejon, J. C. Nieto, T. González, J. Rivera, C. Gonzalez, I. Monteagudo e J. M. Alvaro-Gracia. "AB1117 CLINICAL IMPACT OF MUSCULOSKELETAL ULTRASOUND ON RHEUMATOID ARTHRITIS IN ROUTINE CLINICAL PRACTICE". Annals of the Rheumatic Diseases 79, Suppl 1 (junho de 2020): 1848.3–1848. http://dx.doi.org/10.1136/annrheumdis-2020-eular.6289.
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Background:Musculoskeletal ultrasound (MSUS) is a useful tool to assess disease activity in rheumatoid arthritis (RA) patients. However, it has not yet been established if its use would change treatment decisions within a treat to target strategy or whether it would lead to better outcomes in RA patientsObjectives:Our aim was to determine the impact of MSUS in the clinical management of RA patients and investigate factors associated with subsequent clinical actions by the referring rheumatologistMethods:A prospective analysis of RA patients seen at an MSUS clinic over a 6-month period was undertaken. Pre- and post-US follow-up data (± 3 months) were analyzed. Baseline assessment included clinical features, physical examination and laboratory tests. All MSUS examinations were performed according to EULAR guidelines and using an Esaote MyLab 8 (Esaote, Genoa) with a high frequency (8-15 MHz) transducer. Patients were stratified in groups based on the clinical impact of the MSUS visit: 1) No clinical impact and 2) US findings leading to subsequent clinical action by the referring rheumatologist (including changes in dosages of current rheumatologic treatments, addition/substraction of medications or interventional procedures based on the MSUS results). First, differences between groups were tested using chi-squared and Student-t tests in the univariate analysis. Second, multivariate logistic regression models were employed to investigate factors associated to a change in clinical managementResults:A total of 61 RA patients were included for analysis. Mean age was 61.9± 11.4 years and 51 (83.6%) were female. Disease activity assessment was the most frequent referral reason (43; 70.5%). Overall, MSUS led to a subsequent therapeutic action by the referring rheumatologist in 39 (63.9%) patients, and to a change in the underlying diagnosis and/or in the clinical impression of the chief complaint that generated the referral in 7 (11.5%) patients. Baseline characteristics between both groups are compared in Table 1. In the univariate analysis, the detection of Power Doppler (PD) synovitis/tenosynovitis and 28 swollen joint count were significantly associated with a subsequent clinical action. In the multivariate analysis only PD synovitis/tenosynovitis (OR=3.28; 95%CI 1.06-10.27) remained significantly associated with a change in clinical management (Table 2)Table 1.Baseline characteristics of RA patientsTotal n= 61Change in clinical management n= 39 (63.9%)No change in clinical management n= 22 (36.1%)pAge61.9±11.461.5±12.562.6±9.20.7SexFemale51(83.6%)35(89.7%)16(72.7%)0.09SmokingNon smoker33(54.1%)17(43.6%)16(72.7%)0.08Smoker13(21.3%)11(28.2%)2(9.1%)Former smoker15(24.6%)11(28.2%)13(21.3%)Radiographic erosions29(48.3%)22(57.9%)7(31.8%)0.0528 Tender Joint Count2.3±3.42.7±3.91.6±2.40.228 Swollen Joint Count2±32.6±3.51.1±1.6<0.05ESR (mm/h)28.1±20.626.1±15.531.7±27.40.4CRP (g/L)1±1.51±1.40.9±1.70.7RF (IU/mL)175.8±452.8139.9±249.5243.9±697.40.4ACPA (IU/mL)775.6±998.6619.4±797.11079.9±1,275.90.2US PD synovitis/tenosynovitis37(60.7%)28(71.8%)9(40.9%)<0.05Table 2.Independent factors associated with a change in clinical management based on logistic regression modelpOdds ratio95% C.I.LowerUpper28 Tender Joint Count0.131.240.941.64US PD synovitis/tenosynovitis0.043.281.0610.17Conclusion:The most common indication of MSUS examination in RA patients was disease activity assessment. MSUS findings led frequent changes in therapeutic management and even to a change in the diagnosis in some of cases. The presence of PD synovitis/tenosynovitis was significantly associated to a change in the therapeutic management. These data highlight the impact of MSUS inflammatory findings in RA patients in daily clinical practiceDisclosure of Interests:Juan Molina Collada: None declared, María Pérez: None declared, Isabel Castrejon: None declared, Juan Carlos Nieto Speakers bureau: Pfizer, Abbvie, MSD, Novartis, Janssen, Lilly, Nordic Pharma, BMS, Gebro, FAES Farma, Roche, Sanofi, Teresa González: None declared, Javier Rivera: None declared, Carlos Gonzalez Consultant of: Gilead, Janssen, Novartis,, Speakers bureau: Abbvie, Celgene, Gilead, Janssen, Novartis, Pfizer, Roche, Indalecio Monteagudo: None declared, Jose-Maria Alvaro-Gracia Grant/research support from: Abbvie, Elli-Lilly, MSD, Novartis, Pfizer, Consultant of: Abbvie, BMS, Janssen-Cilag, Elli-Lilly, MSD, Novartis, Pfizer, Sanofi, Tigenix, Roche, UCB, Paid instructor for: Elli-Lilly, Pfizer, Roche, Speakers bureau: Abbvie, BMS, Janssen-Cilag, Elli-Lilly, Gedeon Richter, MSD, Novartis, Pfizer, Sanofi, Tigenix, Roche, UCB
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López-González, R., J. A. Valero Jaimes, M. A. Martin-Martinez, S. Castañeda, C. García Gomez, F. Sánchez-Alonso, C. Gonzalez Juanatey et al. "FRI0330 BODY MASS INDEX AND DISEASE ACTIVITY IN CHRONIC INFLAMMATORY RHEUMATIC DISEASES: RESULTS OF THE CARDIOVASCULAR IN RHEUMATOLOGY (CARMA) PROJECT". Annals of the Rheumatic Diseases 79, Suppl 1 (junho de 2020): 757.1–757. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3591.
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Objectives:Since obesity has been associated with higher inflammatory burden and worse response to therapy in patients with chronic inflammatory joint diseases (CIJDs), we aimed to confirm the potential association between body mass index (BMI) and disease activity in a large series of patients with CIJDs included in the Spanish CARdiovascular in rheuMAtology (CARMA) registry.Methods:Baseline data assessment of patients included from the CARMA project, a 10-year prospective study of patients with rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA) attending outpatient rheumatology clinics from 67 Spanish hospitals. Obesity was defined when BMI (kg/m2) was>30 according to the WHO criteria. Scores used to evaluate disease activity were DAS28 in RA, BASDAI in AS, and modified DAS for PsA.Results:Data from 2,234 patients (775 RA, 738 AS and 721 PsA) were assessed. The mean±SD BMI at the baseline visit were: 26.9±4.8 in RA, 27.4±4.4 in AS and 28.2±4.7 in PsA. Multivariate analyses shown a positive association between BMI and disease activity in patients with RA (β-coefficient: 0.029; 95% CI: 0.01-0.05; p=0.007) and in those with PsA (β-coefficient: 0.036; 95% CI: 0.015-0.058; p=0.001). By contrast, there was no significant association between BMI and disease activity in patients with AS (β-coefficient: 0.001; 95% CI: -0.026-0.03; p=0.926).In patients with RA, female gender (β-coefficient: 0.546; 95% CI: 0.316-0.775; p<0.001) and rheumatoid factor status (seropositivity for RF) (β-coefficient: 0.328; 95% CI: 0.106-0.549; p=0.004) also showed a positive association with disease activity, while physical activity revealed a negative association with disease activity (β-coefficient: -0.280; 95% CI: -0.479-(- 0.081); p=0.006).Besides BMI, female gender (β-coefficient: 0.720; 95% CI: 0.524-0.916; p<0.001), Psoriasis Area Severity Index (β-coefficient: 0.038; 95% CI: 0.012-0.066; p=0.005) and enthesitis (β-coefficient: 0.256; 95% CI: 0.199-0.313; p<0.001) were also positively associated with disease activity in PsA.As observed in RA and PsA, female gender was also associated with disease activity patients with AS (β-coefficient: 0.565; 95% CI: 0.299-0.832; p<0.001).Conclusion:BMI is associated with disease activity in RA and PsA but not in AS. Since obesity is a potentially modifiable factor, disease activity was associated with female gender and RF status in RA and with Psoriasis Area Severity Index and enthesitis in PsA. Adequate control over body weight may improve the outcome of patients with CIJDs and, therefore, weight control should be included in the strategy of management of these patients.Disclosure of Interests:Ruth López-González: None declared, Jesús Alejandro Valero Jaimes: None declared, Maria Auxiliadora Martin-Martinez: None declared, Santos Castañeda: None declared, Carmen García Gomez: None declared, Fernando Sánchez-Alonso: None declared, Carlos Gonzalez Juanatey: None declared, Eva Revuelta-Evrad: None declared, Carolina Perez-Garcia: None declared, Vicenç Torrente Segarra: None declared, Trinidad Pérez Sandoval: None declared, Javier Llorca: None declared, Miguel A González-Gay Grant/research support from: Pfizer, Abbvie, MSD, Speakers bureau: Pfizer, Abbvie, MSD