Bibliografias temáticas / Carbohydrate receptors

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Literatura científica selecionada sobre o tema "Carbohydrate receptors"

Autor: Grafiati

Publicado: 8 de fevereiro de 2025

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Artigos de revistas sobre o assunto "Carbohydrate receptors"

Rauschenberg, Melanie, Sateesh Bandaru, Mark P. Waller e Bart Jan Ravoo. "Peptide-Based Carbohydrate Receptors". Chemistry - A European Journal 20, n.º 10 (13 de fevereiro de 2014): 2770–82. http://dx.doi.org/10.1002/chem.201303777.

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Nosova, A. S., Yu A. Budanova e Yu L. Sebyakin. "Structural features of synthetic glycoconjugates and efficiency of their interaction with glycoprotein receptors on the surface of hepatocytes". Fine Chemical Technologies 14, n.º 5 (14 de novembro de 2019): 7–20. http://dx.doi.org/10.32362/2410-6593-2019-14-5-7-20.

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Objectives. Over the last few years, medicinal chemistry research has been focusing on the creation of molecules that can target particular body systems, organs and tissues, thus abating systemic toxicity and side effects, and, most of all, boosting therapeutic potential. This goal can be achieved through the specific interaction of such drugs with active sites of cellular receptors. For example, glycoprotein receptors that can be found on cellular surfaces in neural tissues and liver parenchyma, selectively bind various glycoproteins and glycosides, facilitating their penetration into cells. This review describes how certain parameters of ligand structure (the nature and length of the spacer between carbohydrate and non-carbohydrate fragments of the molecule, number of carbohydrate residues per molecule, etc.) influence the penetration efficiency of synthetic glycoconjugates into liver cells.Methods. This review article summarizes 75 research papers and discusses data from in vitro and in vivo experiments showing which structures of synthetic carbohydrate derivatives are optimal for targeted drug delivery into liver cells.Results. The surface of liver cells (hepatocytes) contains a significant number of asialoglycoprotein receptors (ASGP-R) that are almost never found elsewhere. This makes ASGP-R an ideal target for the directed treatment of liver diseases, including such difficult, socially important conditions as hepatocellular carcinoma and Hepatitis C. A number of various ligands and targeted (to ASGP-R) delivery systems have been designed. Such molecules always contain derivatives of mono- and disaccharides, most commonly D-glucose, D-galactose, D-lactose and N-acetylglucosamines. This review contains the chemical structures of carbohydrate-based ligands.Conclusions. Glycolipids based on D-carbohydrates, when in liposomes, facilitate penetration into liver cells by a receptor-mediated, clathrin-dependent endocytosis mechanism that is activated upon contact of the carbohydrate-containing ligand fragment with the active site of ASGP-R. It can be addressed by the use of monovalent derivatives of carbohydrates as well as polyvalent glycoconjugates. Alterations in the ligand structure and the number of liposomal modifications can boost the therapeutic effect. The distance between the liposomal surface and the carbohydrate residue (spacer length), as well as the hydrophilic-lipophilic balance of the ligand molecule, have a great effect on the affinity and cellular response.

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Bonar-Law, Richard P., Anthony P. Davis e Brian A. Murray. "Artificial Receptors for Carbohydrate Derivatives". Angewandte Chemie International Edition in English 29, n.º 12 (dezembro de 1990): 1407–8. http://dx.doi.org/10.1002/anie.199014071.

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Castillo, Gaston, Ralf Kleene, Melitta Schachner, Gabriele Loers e Andrew E. Torda. "Proteins Binding to the Carbohydrate HNK-1: Common Origins?" International Journal of Molecular Sciences 22, n.º 15 (29 de julho de 2021): 8116. http://dx.doi.org/10.3390/ijms22158116.

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The human natural killer (HNK-1) carbohydrate plays important roles during nervous system development, regeneration after trauma and synaptic plasticity. Four proteins have been identified as receptors for HNK-1: the laminin adhesion molecule, high-mobility group box 1 and 2 (also called amphoterin) and cadherin 2 (also called N-cadherin). Because of HNK-1′s importance, we asked whether additional receptors for HNK-1 exist and whether the four identified proteins share any similarity in their primary structures. A set of 40,000 sequences homologous to the known HNK-1 receptors was selected and used for large-scale sequence alignments and motif searches. Although there are conserved regions and highly conserved sites within each of these protein families, there was no sequence similarity or conserved sequence motifs found to be shared by all families. Since HNK-1 receptors have not been compared regarding binding constants and since it is not known whether the sulfated or non-sulfated part of HKN-1 represents the structurally crucial ligand, the receptors are more heterogeneous in primary structure than anticipated, possibly involving different receptor or ligand regions. We thus conclude that the primary protein structure may not be the sole determinant for a bona fide HNK-1 receptor, rendering receptor structure more complex than originally assumed.

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Kingsley, D. M., K. F. Kozarsky, M. Segal e M. Krieger. "Three types of low density lipoprotein receptor-deficient mutant have pleiotropic defects in the synthesis of N-linked, O-linked, and lipid-linked carbohydrate chains." Journal of Cell Biology 102, n.º 5 (1 de maio de 1986): 1576–85. http://dx.doi.org/10.1083/jcb.102.5.1576.

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Biochemical, immunological, and genetic techniques were used to investigate the genetic defects in three types of low density lipoprotein (LDL) receptor-deficient hamster cells. The previously isolated ldlB, ldlC, and ldlD mutants all synthesized essentially normal amounts of a 125,000-D precursor form of the LDL receptor, but were unable to process this receptor to the mature form of 155,000 D. Instead, these mutants produced abnormally small, heterogeneous receptors that reached the cell surface but were rapidly degraded thereafter. The abnormal sizes of the LDL receptors in these cells were due to defective processing of the LDL receptor's N- and O-linked carbohydrate chains. Processing defects in these cells appeared to be general since the ldlB, ldlC, and ldlD mutants also showed defective glycosylation of a viral glycoprotein, alterations in glycolipid synthesis, and changes in resistance to several toxic lectins. Preliminary structural studies suggested that these cells had defects in multiple stages of the Golgi-associated processing reactions responsible for synthesis of glycolipids and in the N-linked and O-linked carbohydrate chains of glycoproteins. Comparisons between the ldl mutants and a large number of previously isolated CHO glycosylation defective mutants showed that the genetic defects in ldlB, ldlC, and ldlD cells were unique and that only very specific types of carbohydrate alteration could dramatically affect LDL receptor function.

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Bashiri, Sahra, Prashamsa Koirala, Istvan Toth e Mariusz Skwarczynski. "Carbohydrate Immune Adjuvants in Subunit Vaccines". Pharmaceutics 12, n.º 10 (14 de outubro de 2020): 965. http://dx.doi.org/10.3390/pharmaceutics12100965.

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Modern subunit vaccines are composed of antigens and a delivery system and/or adjuvant (immune stimulator) that triggers the desired immune responses. Adjuvants mimic pathogen-associated molecular patterns (PAMPs) that are typically associated with infections. Carbohydrates displayed on the surface of pathogens are often recognized as PAMPs by receptors on antigen-presenting cells (APCs). Consequently, carbohydrates and their analogues have been used as adjuvants and delivery systems to promote antigen transport to APCs. Carbohydrates are biocompatible, usually nontoxic, biodegradable, and some are mucoadhesive. As such, carbohydrates and their derivatives have been intensively explored for the development of new adjuvants. This review assesses the immunological functions of carbohydrate ligands and their ability to enhance systemic and mucosal immune responses against co-administered antigens. The role of carbohydrate-based adjuvants/delivery systems in the development of subunit vaccines is discussed in detail.

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Sørensen, Anne Louise Tølbøll, Henrik Clausen e Hans H. Wandall. "Carbohydrate clearance receptors in transfusion medicine". Biochimica et Biophysica Acta (BBA) - General Subjects 1820, n.º 11 (novembro de 2012): 1797–808. http://dx.doi.org/10.1016/j.bbagen.2012.07.008.

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Das, Goutam, e Andrew D. Hamilton. "Carbohydrate recognition: Enantioselective spirobifluorene diphosphonate receptors". Tetrahedron Letters 38, n.º 21 (maio de 1997): 3675–78. http://dx.doi.org/10.1016/s0040-4039(97)00725-9.

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Rauschenberg, Melanie, Susanne Bomke, Uwe Karst e Bart Jan Ravoo. "Dynamic Peptides as Biomimetic Carbohydrate Receptors". Angewandte Chemie International Edition 49, n.º 40 (26 de agosto de 2010): 7340–45. http://dx.doi.org/10.1002/anie.201002847.

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Cervantes-Olivier, P., C. Delavier-Klutchko, O. Durieu-Trautmann, S. Kaveri, M. Desmandril e A. D. Strosberg. "The β2-adrenergic receptors of human epidermoid carcinoma cells bear two different types of oligosaccharides which influence expression on the cell surface". Biochemical Journal 250, n.º 1 (15 de fevereiro de 1988): 133–43. http://dx.doi.org/10.1042/bj2500133.

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The beta 2-adrenergic receptors of the human epidermoid carcinoma A431 cells reside on two polypeptide chains revealed by photoaffinity labelling with [125I]iodocyanopindolol-diazirine. These proteins correspond to two distinct populations of N-asparagine-linked glycoproteins: the 55-52 kDa molecules are associated with complex carbohydrate chain(s), the 65-63 kDa component with polymannosidic carbohydrate chain(s). Both types of receptors are present in preconfluent cells, but only the polymannosidic type is found in the postconfluent cells. Moreover, complex chains appear to be associated with the receptors with the highest affinity for (-)-isoproterenol and polymannosidic chains with the receptors with the lowest affinity for this agonist. the carbohydrate moiety of the beta-adrenergic receptor is involved in the expression and function of the beta 2-adrenergic receptors at the surface of the A431 cells, since tunicamycin and monensin, complete and partial inhibitors of glycosylation respectively, diminish the number of binding sites at the cell surface and increase the total number of sites in the cell. In these conditions a diminution of cyclic AMP accumulation is also observed.

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Teses / dissertações sobre o assunto "Carbohydrate receptors"

Joshi, Gururaj G. "New water soluble synthetic carbohydrate receptors". Thesis, University of Bristol, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.557976.

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The macrotricyclic system as a receptor for carbohydrates in organic as well as aqueous media has been extensively studied within the Davis group. The hydrogen bonding and CH-π interactions are the two main non covalent interactions operating for the recognition of carbohydrates in our system. In principle higher affinities could be achieved by enhancing either of these types of interactions. The possibility of enhancing H-bonding interactions with host-guest was explored by the introduction of heterocyclic linkers in the 'temple' receptors. Macrocycle with pyrrole linker 132 and pyridine linker 131 (Figure i) were synthesised and studied for their affinities with different carbohydrate substrates. Pyrrole macrotricycle 132 bound D- Glucose selectively over other substrates with K; = 18 M-1. However pyridine macrotricycle 131 did not show selectivity and higher affinities with any substrates. Figure i. Macrotricycle with pyridine linker 131 and pyrrole linker 132. In collaboration with Roelens group in Firenze, Italy, a series of water soluble C3-symmetric receptors were synthesized and studied for their affinity for carbohydrates. Unfortunately, these series of receptors did not bind the substrates strong enough to be detected by lH NMR titration studies.

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Velasco, Trinidad. "Towards a second generation of macrotricyclic receptors for carbohydrate recognition". Thesis, University of Bristol, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251149.

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Kårström, Andreas. "The effect of carbohydrate mouthrinse on simulated XC-sprint performance". Thesis, Mittuniversitetet, Avdelningen för hälsovetenskap, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-22998.

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The purpose with this study was to investigate the effect of a carbohydrate (CHO) mouth rinse protocol on simulated cross country (XC) sprint. The primaryaim was to investigate ifa 10 secCHO solutionmouth rinsingprotocolimprovedthe finish timein a simulated cross country (XC) sprint(800 meters for female and 1000 meters for male) compared with control (CON).The second aim was to examif post-finish blood lactateconcentrationwouldbe lowercompared with CONwith mouth rinsing. Seven participants(four males and three females)completed four simulated sprints, two CON and two experimentalrinse protocols, CHO solution and placebo (PLA).Time to completion was not different with CHO compared with CON or PLA (203.0 ±16.5 sec, 202.3 ± 15.7 sec, 203.3 ± 14.6respectively.p >.05).Mean power output was CON 264 ± 73, PLA 258 ± 65, CHO 261± 70.Blood lactateat 15 minweresimilar between CHO, CON and and PLA(9.9 ± 3.9 mmol 7.6 ± 4.0 mmol, 10.1 ± 3.7 mmol respectively.p >.05).We concludethat mouth rinsing a CHO solutionfor 10 sechave no effect on high intensity exercise with duration lasting between 3 and 4 minutes.

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Tucker, Kenneth D. "Characterization of the carbohydrate receptors of the Clostridium difficile enterotoxin". Diss., Virginia Tech, 1990. http://hdl.handle.net/10919/37739.

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Clostridium difficile causes pseudomembranous colitis in humans and a similar ileocecitis in hamsters. This organism can colonize the intestines after antibiotic therapy disrupts the normal intestinal microflora. Once established in the intestines, the organism causes disease by producing two toxins, designated toxin A and toxin B. Only toxin A is active on intestinal epithelium, thus toxin A is the cause of the initial tissue damage in the intestines. In order for a toxin to affect a cell, it must first bind to the cell. Toxin A has been shown to bind to Galα 1-3Galβ 1-4GlcNAc on the intestinal epithelium of hamsters. I provide evidence that toxin A can use this trisaccharide as a functional receptor on cell lines, and that the expression of the carbohydrate receptor increases the sensitivity of the cells to toxin A Furthermore, the intestinal epithelium of infant hamsters bound less toxin A at 37C than did the adult tissue, and infants are less sensitive to the disease caused by C. difficile than are adults. This provides further evidence that the activity of toxin A is increased by the binding of the toxin to Galα 1-3Galβ 1-4GlcNAc. Even though Galα 1-3Galβ 1-4GlcNAc was a receptor for toxin A on animal cells, it probably is not a receptor for toxin A in humans, because people do not normally express this carbohydrate. Instead, I found that toxin A bound to the carbohydrate antigens designated I, X, and Y, which are present on the intestinal epithelium of humans. These carbohydrates could be receptors for toxin A The possible significance of these receptors is discussed.
Ph. D.

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Sakonsinsiri, Chadamas. "Carbohydrate-based inhibitors and multivalent probes for LOX-1 and DC-SIGN receptors". Thesis, University of Leeds, 2016. http://etheses.whiterose.ac.uk/14317/.

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Morgan, David Alexander. "The role of neuropeptides Y and neuropeptide Y receptors in the control of carbohydrate metabolism". Thesis, Imperial College London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267076.

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Neu, Ursula [Verfasser], e Thilo [Akademischer Betreuer] Stehle. "Structural and Functional Analysis of Polyomavirus Attachment to Carbohydrate Receptors / Ursula Neu ; Betreuer: Thilo Stehle". Tübingen : Universitätsbibliothek Tübingen, 2013. http://d-nb.info/1162844388/34.

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Enache, Liviu. "Chronic viral hepatitis and human lipid and carbohydrate metabolism". Thesis, Lyon 1, 2014. http://www.theses.fr/2014LYO10176.

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L'infection au virus de l'hépatite B (VHB) est étroitement liée au métabolisme énergétique hépatique. La réplication du virus est contrôlée en principal par des facteurs de transcription et récepteurs nucléaires tels que PPARa, HNF4a et Foxül, impliqués dans ce métabolisme. Ainsi, la réplication du virus est augmentée par la privation de nutriments et le stress énergétique en modèles cellulaires, et par le jeûne, en modèles murins. PGC-la, un régulateur majeur de la réponse métabolique adaptative au jeûne, est impliqué dans l'augmentation de la transcription du VHB par son interaction avec plusieurs facteurs de transcription. Il est connu que le récepteur des acides biliaires, FXRa, qui est capable d'activer le promoteur de Core du VHB, est co-activaté par PGC-la. Un autre acteur important dans l'adaptation métabolique à la privation d'énergie est la protéine déacétylase SIRTl. Lorsqu'il est activé, SIRTl hépatique est capable de désacétyler et activer autant PGC-la que FXRa. Ces données nous ont amenés à émettre l'hypothèse que SIRTl pourrait coopérer avec FXRa et PGC-la pour augmenter la transcription du VHB. Dans un premier travail, nous avons donc étudié le rôle de la coopération de ces trois facteurs métaboliques dans la réplication du virus. Ça nous a permis de décrire un nouveau réseau métabolique, composé de FXRa, PGC-la et SIRTl, qui régule l'activité transcriptionnelle du VHB. Nous avons montré que SIRTl augmente l'activité du promoteur de Core par l'intermède d'autre facteurs, parmi lesquels, FXRa. Nous avons en outre observé que la fonction de déacétylase de SIRTl était nécessaire pour l'amplification de l'effet de FXRa sur VHB promoteur de Core. Une autre cible de SIRTl, connue pour son activité co-activatrice sur FXRa, est PGC-la. Grâce à une série d'expériences de surexpression et suppression, nous avons montré que non seulement la co-activation de FXRa par PGC-la est potentialisée par SIRTl, mais la présence de PGC-la est nécessaire pour l'effet de SIRTl sur l'activation du promoteur de Core VHB induite par FXRa. Ces données suggèrent que FXRa, PGC-la et SIRTl coopèrent dans la modulation de l'activité transcriptionnelle du promoteur de Core. Nous avons ensuite confirmé nos observations initiales et avons montré que l'activation de l'axe SIRTl/PGC-la/FXRa induit la transcription de l'ARN de VHB dans des lignées cellulaires d'origine hépatique et non-hépatique. Ces résultats renforcent l'idée que la réplication du VHB peut être modulée en fonction de l'état nutritionnel. Les rapports des études précédentes menées in vitro et sur des modèles animaux suggèrent que la transcription du VHB est contrôlée de la même manière que les gènes de la néoglucogenèse. Notre hypothèse a été que chez l'homme, la réplication du VHB montrerait des fluctuations diurnes, selon les périodes de la journée de jeûne et de réalimentation. Le but de la deuxième étude a été donc de déterminer si la charge viral du VHB plasmatique montre des variations importantes tout au long du nichthemeron chez les patients chroniquement infectés par VHB, avec une réplication virale active [etc...]
Hepatitis B virus (HBV) infection is tightly linked with hepatic fuel metabolism. HBV replication depends on the activity of several liver-enriched nuclear receptors and transcription factors, such as PPARa, HNF4a, and Fox01, involved in the metabolic adaptive response to fasting. In the first part of our work, we identified a metabolic subnetwork that enhances the activity of HBV core promoter. FXRa (NR1H4), PPAR gamma coactivator 1a and SIRT1, the members of this regulatory axis, cooperate to increase HBV transcription. The three molecules are themselves key factors of liver metabolism, linking HBV replication to complex metabolic cues, such as energy status and nutrient availability during the fasting-refeeding cycles. We then observed the existence of a circadian cycle of HBV replication in humans, underlining the role of nutrient availability in the modulation of HBV replication, previously predicted by experimental models. The second part of the work focused on the plasma cell-free nucleic acids as potential biomarkers in chronic viral hepatitis. Due to the multiple links between HBV replication and cellular factors involved in fuel metabolism, we hypothesized that plasma mRNAs corresponding to these factors may constitute potential biomarkers for chronic hepatitis B. We successfully detected more than 30 plasma mRNA sequences corresponding to enzymes, transporters, nuclear receptors and transcription factors involved in fatty acids synthesis and oxidation, cholesterol synthesis, transport and excretion, and energy sensing and expenditure. The circadian variation and the multiple correlations in the expression patterns of these plasma transcripts are similar to those previously described in cells both in vitro and in vivo. This suggests that cell- free mRNAs may provide a "virtual biopsy" of the transcriptional status of the organism. Moreover, we found significant differences in the plasma mRNA profiles of HBV carriers compared with healthy controls, similar to those found in experimental models of infection, suggesting that these transcripts may also serve as biomarkers of liver disease. Further research is warranted to shed new light on the complex relationship between HBV life cycle and host lipid-carbohydrate-fuel metabolism and may lead to the identification of both actionable targets in antiviral therapy, and putative biomarkers in chronic hepatitis B

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Bulut, Haydar [Verfasser]. "Structures of carbohydrate, cysteine and cystine binding receptors of ATP-Binding Cassette (ABC) Transporters / Haydar Bulut". Berlin : Freie Universität Berlin, 2012. http://d-nb.info/1026790263/34.

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Eriksson, Magdalena Karin Matilda [Verfasser]. "C-type Lectin Receptors: from Immunomodulatory Carbohydrate Ligands to a Role in Murine Colitis / Magdalena Karin Matilda Eriksson". Berlin : Freie Universität Berlin, 2013. http://d-nb.info/1044576324/34.

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Livros sobre o assunto "Carbohydrate receptors"

Gregory, Bock, Harnett Sara e Symposium on Carbohydrate Recognition in Cellular Function (1988 : Ciba Foundation), eds. Carbohydrate recognition in cellular function. Chichester [England]: Wiley, 1989.

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Bellissimo, Nicola. Fat and carbohydrate induced suppression of food intake via CCK(A) receptors in rats. Ottawa: National Library of Canada, 2003.

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C, Wong Simon Y., e Arsequell Gemma, eds. Immunobiology of carbohydrates. Georgetown, Tex: Landes Bioscience/Eurekah.com, 2003.

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Quesenberry, Michael Stephen. Molecular analysis of calcium-dependent carbohydrate-recognition domains. 1991.

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Hartman, Adam L. Amino Acids in the Treatment of Neurological Disorders. Editado por Dominic P. D’Agostino. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190497996.003.0035.

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Studies of metabolism- and diet-based therapies in epilepsy and neuroprotection have focused primarily on the quality and quantity of fat supplementation or carbohydrate restriction. However, protein is another key dietary component that has not been as thoroughly studied. A number of amino acids have been shown to stop, terminate, or prevent seizures. In addition, some have been shown to exert neuroprotective effects in other neurological disorders. Amino acids (and their metabolites) may exert their effects by acting at membrane or cytoplasmic receptors, serving as substrates for membrane transporters and as modulators of signaling pathway activity. This chapter highlights examples of each of these mechanisms of action in select nervous system disorders.

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Droz, Anne Sophie. Synthesis of chiral macrocyclic receptors for Carbohydrates. 2000.

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Immunobiology of carbohydrates. Georgetown, TX: Eurekah.com/Landes Bioscience ; Kluwer Academic/Plenum, 2004.

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(Editor), Thomas Schrader, e Andrew D. Hamilton (Editor), eds. Functional Synthetic Receptors. Wiley-VCH, 2005.

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Schrader, Thomas, e Andrew D. Hamilton. Functional Synthetic Receptors. Wiley-VCH Verlag GmbH, 2005.

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Schrader, Thomas, e Andrew D. Hamilton. Functional Synthetic Receptors. Wiley & Sons, Incorporated, John, 2006.

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Capítulos de livros sobre o assunto "Carbohydrate receptors"

Davis, Anthony P., e Tony D. James. "Carbohydrate Receptors". In Functional Synthetic Receptors, 45–109. Weinheim, FRG: Wiley-VCH Verlag GmbH & Co. KGaA, 2005. http://dx.doi.org/10.1002/352760572x.ch2.

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Davis, Anthony P. "Carbohydrate Receptors". In Supramolecular Chemistry in Water, 161–91. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2019. http://dx.doi.org/10.1002/9783527814923.ch5.

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Ohlsen, K., T. A. Oelschlaeger, J. Hacker e A. S. Khan. "Carbohydrate Receptors of Bacterial Adhesins: Implications and Reflections". In Glycoscience and Microbial Adhesion, 17–65. Berlin, Heidelberg: Springer Berlin Heidelberg, 2008. http://dx.doi.org/10.1007/128_2008_10.

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Fukuda, Michiko N. "Identification of Endothelial Cell Surface Carbohydrate-Binding Receptors by Carbohydrate Ligand Mimicry Peptides". In Advances in Experimental Medicine and Biology, 57–66. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4614-3381-1_5.

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McWilliam, A. S., P. Tree e S. Gordon. "Carbohydrate recognition receptors of the macrophage and their regulation". In Mononuclear Phagocytes, 224–32. Dordrecht: Springer Netherlands, 1992. http://dx.doi.org/10.1007/978-94-015-8070-0_30.

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Lee, Y. C. "Binding Modes of Mammalian Hepatic Gal/GalNAc Receptors". In Ciba Foundation Symposium 145 - Carbohydrate Recognition in Cellular Function, 80–101. Chichester, UK: John Wiley & Sons, Ltd., 2007. http://dx.doi.org/10.1002/9780470513828.ch6.

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Lee, K. K., H. B. Sheth, R. T. Irvin, R. S. Hodges, W. Paranchych e O. Hindsgaul. "Peptide-carbohydrate interactions: Understanding bacterial adherence to host cell receptors". In Peptides, 672–74. Dordrecht: Springer Netherlands, 1994. http://dx.doi.org/10.1007/978-94-011-0683-2_222.

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Mashayekh, Siavash, Elizabeth A. D’Ambrosio e Catherine L. Grimes. "Methods to Investigate Innate Immune Receptors and Their Carbohydrate-Based Ligands". In ACS Symposium Series, 127–47. Washington, DC: American Chemical Society, 2020. http://dx.doi.org/10.1021/bk-2020-1346.ch008.

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Heicappell, R., H. Buszello, S. Gabius, R. Ackermann e H. J. Gabius. "Endogenous receptors fore carbohydrate ligands in human renal cell carcinoma (RCC)". In Lectins and Cancer, 105–22. Berlin, Heidelberg: Springer Berlin Heidelberg, 1991. http://dx.doi.org/10.1007/978-3-642-76739-5_8.

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Czech, Michael P., Robert E. Lewis e Silvia Corvera. "Multifunctional Glycoprotein Receptors for Insulin and the Insulin-Like Growth Factors". In Ciba Foundation Symposium 145 - Carbohydrate Recognition in Cellular Function, 27–44. Chichester, UK: John Wiley & Sons, Ltd., 2007. http://dx.doi.org/10.1002/9780470513828.ch3.

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Trabalhos de conferências sobre o assunto "Carbohydrate receptors"

Tzeng, Tzuen-Rong J., Yunyan R. Cheng, Reza Saeidpourazar, Siddharth Sanjeev Aphale e Nader Jalili. "Adhesin-Specific Nanomechnical Cantilever Biosensors for Detection of Microorganisms". In ASME 2009 Second International Conference on Micro/Nanoscale Heat and Mass Transfer. ASMEDC, 2009. http://dx.doi.org/10.1115/mnhmt2009-18487.

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Considerable evidence has indicated that lectins (adhesins) on bacterial surfaces play an important role in the initiation of infection by mediating bacterial adherence to epithelial cell, especially in the gastrointestinal and urinary tracts. Many bacteria express adhesins on their surfaces in the form of specialized organelles that seek and bind to cognate receptors on the surface of mucosal cells. Some of these specific receptors have been reported and many of them are carbohydrates in nature. We have explored the use of specific carbohydrate receptors for the functionalization of nanoparticles and demonstrated their binding specificities and their ability to mediate aggregations of targeted bacteria. Based on these binding specificities, here we report the development of adhensin-specific nanomechanical cantilever (microcantilever) biosensors for the detection of their targeted microorganisms.

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Shaw, David M., Peter Stern, David V. Renouf, Michael J. Davies e Elizabeth F. Hounsell. "THE FUNCTION OF GLYCOSYLATION IN LEUCINE-RICH REPEAT (LRR) PROTEIN RECEPTORS". In XXIst International Carbohydrate Symposium 2002. TheScientificWorld Ltd, 2002. http://dx.doi.org/10.1100/tsw.2002.397.

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Wu, Albert M. "CARBOHYDRATE STRUCTURAL UNITS IN GLYCOSPHINGOLIPIDS AS RECEPTORS FOR Gal AND GalNAc REACTIVE LECTINS". In XXIst International Carbohydrate Symposium 2002. TheScientificWorld Ltd, 2002. http://dx.doi.org/10.1100/tsw.2002.570.

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Meyer, Bernd, Jens Klein, Moriz Mayer, Robert Meinecke e Heiko Moller. "STD-NMR TO SCREEN LIBRARIES AND TO CHARACTERIZE BINDING OF CARBOHYDRATE LIGANDS TO RECEPTORS". In XXIst International Carbohydrate Symposium 2002. TheScientificWorld Ltd, 2002. http://dx.doi.org/10.1100/tsw.2002.389.

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Bakhit, C., D. Lewis, R. Billings e B. Malfroy. "CELLULAR CATABOLISM OF RECOMBINANT TISSUE-TYPE PLASMINOGEN ACTIVATOR: IDENTIFICATION AND CHARACTERIZATION OF A NOVEL HIGH AFFINITY UPTAKE SYSTEM ON RAT HEPATOCYTES". In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644400.

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The uptake, internalization and intracellular degradation of 125I-labeled rt-PA (125I-rt-PA) by isolated rat hepatocytes was investigated. Incubation at 37°C resulted in internalization of 125I-rt-PA, followed by the appearance of labeled trichloroacetic acid-soluble (TCA) material in the inclubation media due to degradation of rt-PA. Degradation of rt-PA was inhibited by the presence of NH4Cl (10mM) or chloroquine (ImM) (lysosoma tropic agents) in the incubation media. This suggests that rt-PA degradation occurs intracellularly, perhaps within the lysosomes. 125I-rt-PA was taken up by rat hepatocytes through a specific, high affinity mechanism. Scatchard analysis of the data indicated that 106 molecules of rt-PA were taken up per cell/hour and the calculated dissociation constant was lOnM. Uptake of 125I-rt-PA was not inhibited by glycopeptides isolated from rt-PA nor by several other glycoproteins known to be cleared by identified hepatic receptors. These results suggest that the uptake of rt-PA by rat hepatocytes involves a receptor specific for t-PA and is not mediated by a carbohydrate specific receptor.

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Thomas, Wendy E., Evgeni V. Sokurenko e Viola Vogel. "How Bacteria Bind More Strongly Under Mechanical Force: The Catch-Bond FimH". In ASME 2003 International Mechanical Engineering Congress and Exposition. ASMEDC, 2003. http://dx.doi.org/10.1115/imece2003-43680.

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We study a protein that responds to mechanical force in most striking manner. We demonstrate that Escherichia coli bacteria need shear stress to bind to certain tissues and model surfaces; they bind strongest precisely when the body tries to wash them off. We have determined that the protein responsible for this behavior is FimH, a ubiquitous adhesion protein in intestinal bacteria that mediates adhesion to host cells via the carbohydrate mannose. Although mechanical force noramlly decreases bond lifetimes, we have shown that the bond betweeen FimH and simple mono-mannose receptors is s “catch-bond” that lasts longer under shear stress. In contrast, structural variations in either FimH or the receptor cause a stronger mode of adhesion in static conditions with little or no activation under force. We derive a structural for how mechanical force switches FimH to a strong binding mode by using steered molecular dynamics simulations, and validate the predictions with subsequent site-directed mutagenesis. The physiological consequences as well as the engineering principles suggested by the structural model will be discussed.

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Pogodaeva, P. S. "Changes in the parameters of a clinical blood test in rats using hypoglycemic agents for the potentiation of drugs with a hepatoprotective effect". In SPbVetScience. FSBEI HE St. Petersburg SUVM, 2023. http://dx.doi.org/10.52419/3006-2023-11-28-34.

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Glucagon-like peptide-1 is an isulin-like peptide hormone from the incretin family. The most popular pharmaceutical analogue of GLP-1 at the moment is liraglutide. GLP-1 receptors are localized in many areas of the brain responsible for the regulation of metabolic processes and eating behavior and in specific areas of the pancreas, heart, blood vessels, immune system, skin and adipose tissue, gastrointestinal tract and kidneys. We can definitely say that the effect of liraglutide extends to all tissues equipped with GLP-1 receptors, while the effect of the drug on the cardiovascular system, immune system, kidneys and gastrointestinal tract is still being studied. Also interesting is the possible effect of liraglutide on the liver, as an organ directly related to lipid and carbohydrate metabolism. In this article, we analyze the possibilities of using Saxenda, the main active ingredient of which is liraglutide, to potentiate the hepatoprotective effects of the Hepaton-vet drug in groups of rats with induced hepatopathy, evaluating the effect of these drugs on the parameters of a clinical blood test.

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Marquerie, G., A. Duperray, G. Uzan e R. Berthier. "BIOSYNTHETIC PATHWAYS OF THE PLATELET FIBRINOGEN RECEPTOR IN HUMAN MEGAKARYOCYTES". In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642954.

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Interaction between cells and between cells and extracellular matrices are critical for a number of biological processes, including organ development, cell differenciation, cell motility, and the inimune' response. These interactions are mediated by a family of adhesion receptors that recognize short sequences such as Arg-Gly-Asp (RGD). These receptors share similar structural properties. They are heterodimers composed of a and B subunits and sometime express common epitopes. This suggests that the structural and functional relationship of these receptors may result from the transcription of related genes or may arise from cell specific post-transcriptional events. Thus, analysis of the biosynthesis and processing of these receptors would provide valuable insights into the molecular mechanism which control their expression at the surface,of different cells. Platelet membrane glycoprotein (GP) IIb-IIIa is a member of this receptor family. This protein is a non covalent heterodimer composed of two distinct polypeptides, Glib which consists of two subunits Ilba and IlbB (Mr = 116 kD, Mr = 25 kD) and GPIIIa (Mr = 100 kD, reduced). GPIIb-IIIa functions at site of platelet aggregation and serves as receptor for RGD containing factors including fibrinogen, fibronectin and von Willebrand factor. We report here on the investigation of the biosynthetic pathways of this RGD receptor in human megakaryocytes. High number of megakaryocytic cells from the megakaryoblastic stage to the polyploid mature megakaryocyte were obtained from liquid culture of cryopreserved leukocyte stem cell concentrates from patients with chronic myelogenous leukemia (CML). After sorting, using a FACS IV and indirect immunofluores-cent labeling with monoclonal antibodies anti-GPIIb-IIIa, 95 % of the cells in culture were of the megakaryocytic lineage. These megakarocytes represented an excellent tool to delineate at the molecular level events associated with the biosynthesis of GPIIb-IIIa.Metabolic labeling and pulse-chase experiments indicated that GPIIb and GPIIIa are synthesized from separate mRNA and that the two subunits of GPIIb derive from a common precursor. This was further confirmed by cell-free translation of megakaryocyte mRNA and the identification of separate cDNA containing sequences coding for the pro-GPIIb and for GPIIIa. These cDNA were isolated from a Xgt11 expression library constructed with purified megakaryocyte RNA, and were used to size the messengers coding for the two polypeptides. A single mRNA species of 3.9 kB was found to encode the pro-GPIIb, whereas two different mRNA species of 2.9 kB and 4. 1 kB were identified with the GPIIIa cDNA.The newly synthesized GPIIIa associates early with the pro-GPIIb in the rough endoplasmic reticulum. Examination of the glycosylation pathways with endoglycosidase H, tunicamycin and monensin indicated that high mannose oligosaccharides are added to the GPIIIa and pro-GPIIb polypeptide backbone. The pro-GPIIb is then processed with conversion of high mannose to the complex type carbohydrate, whereas GPIIIa remains endoH sensitive. Glycosylation of pro-GPIIb-IIIa and processing of oligosaccharides are prerequisite for proteolytic maturation of pro-GPIIb and the expression of the mature complex at the surface of the cell. Thus post-translational processing of GPIIb-IIIa requires an early assembly of the complex. This may have important implications in the maturation of megakaryocyte granules and in the molecular mechanism underlying the Glanzmann thrombastenic disease.

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Bock, Klaus, Socorro Vazquez Campos, Dorthe Damgaard, Phaedria St. Hilaire e Morten Meldal. "SULFATED PEPTIDES AS HEPARIN MIMICS DESIGNED FOR FGF RECEPTOR INTERACTIONS". In XXIst International Carbohydrate Symposium 2002. TheScientificWorld Ltd, 2002. http://dx.doi.org/10.1100/tsw.2002.387.

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Takahashi, Noriko, Joel Cohen-Solal, Annie Galinha, Wolf Herman Fridman, Catherine Sautes-Fridman e Koichi Kato. "N-GLYCOSYLATION PROFILE OF RECOMBINANT HUMAN SOLUBLE Fc[GAMMA] RECEPTOR III". In XXIst International Carbohydrate Symposium 2002. TheScientificWorld Ltd, 2002. http://dx.doi.org/10.1100/tsw.2002.562.

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