Artigos de revistas: "Boron-neutron capture therapy"

1

Taskaev, S. Yu. "Boron Neutron Capture Therapy". Physics of Atomic Nuclei 84, n.º 2 (março de 2021): 207–11. http://dx.doi.org/10.1134/s106377882101021x.

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ONO, Koji, Minoru SUZUKI, Shinichiro MASUNAGA, Natsuko KONDO, Yoshinori SAKURAI, Hiroki TANAKA, Yuko KINASHI e Akira MARUHASHI. "Boron Neutron Capture Therapy". RADIOISOTOPES 61, n.º 4 (2012): 209–22. http://dx.doi.org/10.3769/radioisotopes.61.209.

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FREEMANTLE, MICHAEL. "BORON NEUTRON CAPTURE THERAPY". Chemical & Engineering News 80, n.º 34 (26 de agosto de 2002): 13. http://dx.doi.org/10.1021/cen-v080n034.p013.

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Beddoe, A. H. "Boron neutron capture therapy." British Journal of Radiology 70, n.º 835 (julho de 1997): 665–67. http://dx.doi.org/10.1259/bjr.70.835.9245876.

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Slatkin, Daniel N. "Boron neutron-capture therapy". Neutron News 1, n.º 4 (janeiro de 1990): 25–28. http://dx.doi.org/10.1080/10448639008229357.

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Ota, Ichiro, e Tadashi Kitahara. "Boron Neutron Capture Therapy (BNCT)". Practica Oto-Rhino-Laryngologica 107, n.º 12 (2014): 937–46. http://dx.doi.org/10.5631/jibirin.107.937.

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7

&NA;. "Improving boron neutron capture therapy". Inpharma Weekly &NA;, n.º 971 (janeiro de 1995): 8. http://dx.doi.org/10.2165/00128413-199509710-00016.

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Mumot, M. "325. Boron Neutron Capture Therapy". Reports of Practical Oncology & Radiotherapy 8 (2003): S354—S355. http://dx.doi.org/10.1016/s1507-1367(03)70808-6.

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9

Kato, I. "S17.1 Boron neutron capture therapy". Oral Oncology Supplement 1, n.º 1 (janeiro de 2005): 63. http://dx.doi.org/10.1016/s1744-7895(05)80118-x.

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Sauerwein, Wolfgang A. G., Lucie Sancey, Evamarie Hey-Hawkins, Martin Kellert, Luigi Panza, Daniela Imperio, Marcin Balcerzyk et al. "Theranostics in Boron Neutron Capture Therapy". Life 11, n.º 4 (10 de abril de 2021): 330. http://dx.doi.org/10.3390/life11040330.

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Boron neutron capture therapy (BNCT) has the potential to specifically destroy tumor cells without damaging the tissues infiltrated by the tumor. BNCT is a binary treatment method based on the combination of two agents that have no effect when applied individually: 10B and thermal neutrons. Exclusively, the combination of both produces an effect, whose extent depends on the amount of 10B in the tumor but also on the organs at risk. It is not yet possible to determine the 10B concentration in a specific tissue using non-invasive methods. At present, it is only possible to measure the 10B concentration in blood and to estimate the boron concentration in tissues based on the assumption that there is a fixed uptake of 10B from the blood into tissues. On this imprecise assumption, BNCT can hardly be developed further. A therapeutic approach, combining the boron carrier for therapeutic purposes with an imaging tool, might allow us to determine the 10B concentration in a specific tissue using a non-invasive method. This review provides an overview of the current clinical protocols and preclinical experiments and results on how innovative drug development for boron delivery systems can also incorporate concurrent imaging. The last section focuses on the importance of proteomics for further optimization of BNCT, a highly precise and personalized therapeutic approach.

11

Edgecock, Rob. "Accelerator-driven boron neutron capture therapy". International Journal of Modern Physics A 29, n.º 14 (26 de maio de 2014): 1441004. http://dx.doi.org/10.1142/s0217751x14410048.

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Boron Neutron Capture Therapy is a binary treatment for certain types of cancer. It works by loading the cancerous cells with a boron-10 carrying compound. This isotope has a large cross-section for thermal neutrons, the reaction producing a lithium nucleus and alpha particle that kill the cell in which they are produced. Recent studies of the boron carrier compound indicate that the uptake process works best in particularly aggressive cancers. Most studied is glioblastoma multiforme and a trial using a combination of BNCT and X-ray radiotherapy has shown an increase of nearly a factor of two in mean survival over the state of the art. However, the main technical problem with BNCT remains producing a sufficient flux of neutrons for a reasonable treatment duration in a hospital environment. This paper discusses this issue.

12

Wuu, C. S., H. I. Amols, P. Kliauga, L. E. Reinstein e S. Saraf. "Microdosimetry for Boron Neutron Capture Therapy". Radiation Research 130, n.º 3 (junho de 1992): 355. http://dx.doi.org/10.2307/3578381.

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Barth, Rolf F., Albert H. Soloway e Ralph G. Fairchild. "Boron Neutron Capture Therapy for Cancer". Scientific American 263, n.º 4 (outubro de 1990): 100–107. http://dx.doi.org/10.1038/scientificamerican1090-100.

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14

Sauerwein, Wolfgang. "81 Boron neutron capture therapy (BNCT)". Radiotherapy and Oncology 40 (janeiro de 1996): S23. http://dx.doi.org/10.1016/s0167-8140(96)80088-0.

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Barth, Rolf F., e Albert H. Soloway. "Perspective on boron neutron capture therapy". International Journal of Radiation Oncology*Biology*Physics 28, n.º 5 (março de 1994): 1059–60. http://dx.doi.org/10.1016/0360-3016(94)90478-2.

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16

Yamamoto, Tetsuya, Kei Nakai e Akira Matsumura. "Boron neutron capture therapy for glioblastoma". Cancer Letters 262, n.º 2 (abril de 2008): 143–52. http://dx.doi.org/10.1016/j.canlet.2008.01.021.

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17

Hatanaka, H. "Boron neutron capture therapy for tumors". International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes 37, n.º 1 (janeiro de 1986): 79–80. http://dx.doi.org/10.1016/0883-2889(86)90215-7.

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18

Hu, Kuan, Zhimin Yang, Lingling Zhang, Lin Xie, Lu Wang, Hao Xu, Lee Josephson, Steven H. Liang e Ming-Rong Zhang. "Boron agents for neutron capture therapy". Coordination Chemistry Reviews 405 (fevereiro de 2020): 213139. http://dx.doi.org/10.1016/j.ccr.2019.213139.

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19

Salt, C., A. J. Lennox, M. Takagaki, J. A. Maguire e N. S. Hosmane. "Boron and gadolinium neutron capture therapy". Russian Chemical Bulletin 53, n.º 9 (setembro de 2004): 1871–88. http://dx.doi.org/10.1007/s11172-005-0045-6.

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20

Howard, William Bruce. "Accelerator-based boron neutron capture therapy". Medical Physics 25, n.º 6 (junho de 1998): 1060. http://dx.doi.org/10.1118/1.598286.

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21

MORRIS, J. H. "ChemInform Abstract: Boron Neutron Capture Therapy". ChemInform 22, n.º 32 (22 de agosto de 2010): no. http://dx.doi.org/10.1002/chin.199132313.

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22

Metwally, Walid A., Yumna A. Alharahsheh, Entesar Z. Dalah e Husam Al-Omari. "Utilizing neutron generators in boron neutron capture therapy". Applied Radiation and Isotopes 174 (agosto de 2021): 109742. http://dx.doi.org/10.1016/j.apradiso.2021.109742.

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23

Wolber, Gerd. "Fast Neutron Beams for Boron Neutron Capture Therapy?" Zeitschrift für Medizinische Physik 14, n.º 1 (2004): 55–63. http://dx.doi.org/10.1078/0939-3889-00192.

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24

Takahashi, Minoru, Tooru Kobayashi, Mingguang Zhang, Michael Mak, Jiri Stefanica, Vaclav Dostal e Wei Zhao. "ICONE19-43192 STUDY ON HIGH SPEED LITHIUM JET FOR NEUTRON SOURCE OF BORON NEUTRON CAPTURE THERAPY (BNCT)". Proceedings of the International Conference on Nuclear Engineering (ICONE) 2011.19 (2011): _ICONE1943. http://dx.doi.org/10.1299/jsmeicone.2011.19._icone1943_74.

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25

Ogura, K., A. Yamazaki, H. Yanagie, M. Eriguchi, E. H. Lehmann, G. Küehne, G. Bayon, K. Maruyama e H. Kobayashi. "Neutron capture autoradiography for a study on boron neutron capture therapy". Radiation Measurements 34, n.º 1-6 (junho de 2001): 555–58. http://dx.doi.org/10.1016/s1350-4487(01)00227-x.

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26

Sumitani, Shogo, e Yukio Nagasaki. "Boron neutron capture therapy assisted by boron-conjugated nanoparticles". Polymer Journal 44, n.º 6 (4 de abril de 2012): 522–30. http://dx.doi.org/10.1038/pj.2012.30.

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27

Susilowati, Anggraeni Dwi, Kusminarto Kusminarto e Yohannes Sardjono. "Boron Neutron Capture Therapy (BNCT) using Compact Neutron generator". Indonesian Journal of Physics and Nuclear Applications 1, n.º 2 (30 de junho de 2016): 73. http://dx.doi.org/10.24246/ijpna.v1i2.73-80.

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Boron Neutron Capture Therapy (BNCT) must be appropriate with ﬁve criteria from IAEA. These criteria in order to prevent neutron beam output harm the patient. It can be by using Collimator of neutron source Compact Neutron Generator (CNG) and Monte Carlo simulation method with N particles 5 .CNG is developed by deuteriumtritium reaction (DT) and deuterium-deuterium (DD) reaction. The manufacture result of the collimator is obtained epithermal neutron ﬂux value of 1.69e-9 n/cm^2s for D-T reaction and 8e6 n/cm^2s for D-D reaction, ratio of epithermal and thermal is 1.95e-13 Gy cm^2/n for D-T reaction and for D-D reaction, ratio of fast neutron component is 1.69e-13 Gy cm^2/n for D-T reaction and for D-D reaction, ratio of gamma component is 1.18e-13 Gy cm^2/nfor D-T reaction and for D-D reaction. The Latest reaction is current ratio 0.649 for D-T reaction and 0.46 for D-D reaction.

28

Kiyanagi, Yoshiaki. "Accelerator-based neutron source for boron neutron capture therapy". Therapeutic Radiology and Oncology 2 (novembro de 2018): 55. http://dx.doi.org/10.21037/tro.2018.10.05.

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29

Perks, C. A., e J. A. B. Gibson. "Neutron Spectrometry and Dosimetry for Boron Neutron Capture Therapy". Radiation Protection Dosimetry 44, n.º 1-4 (1 de novembro de 1992): 425–28. http://dx.doi.org/10.1093/oxfordjournals.rpd.a081477.

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30

Perks, C. A., e J. A. B. Gibson. "Neutron Spectrometry and Dosimetry for Boron Neutron Capture Therapy". Radiation Protection Dosimetry 44, n.º 1-4 (1 de novembro de 1992): 425–28. http://dx.doi.org/10.1093/rpd/44.1-4.425.

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31

Kasatov, D., A. Koshkarev, A. Kuznetsov, A. Makarov, Yu Ostreinov, I. Shchudlo, I. Sorokin, T. Sycheva, S. Taskaev e L. Zaidi. "The accelerator neutron source for boron neutron capture therapy". Journal of Physics: Conference Series 769 (novembro de 2016): 012064. http://dx.doi.org/10.1088/1742-6596/769/1/012064.

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32

Zaidi, L., E. A. Kashaeva, S. I. Lezhnin, G. N. Malyshkin, S. I. Samarin, T. V. Sycheva, S. Yu Taskaev e S. A. Frolov. "Neutron-beam-shaping assembly for boron neutron-capture therapy". Physics of Atomic Nuclei 80, n.º 1 (janeiro de 2017): 60–66. http://dx.doi.org/10.1134/s106377881701015x.

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33

Golubev, S. V., I. V. Izotov, S. V. Razin, A. V. Sidorov e V. A. Skalyga. "A Compact Neutron Source for Boron Neutron Capture Therapy". Radiophysics and Quantum Electronics 59, n.º 8-9 (janeiro de 2017): 682–89. http://dx.doi.org/10.1007/s11141-017-9735-9.

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34

Ailuno, Giorgia, Alice Balboni, Gabriele Caviglioli, Francesco Lai, Federica Barbieri, Irene Dellacasagrande, Tullio Florio e Sara Baldassari. "Boron Vehiculating Nanosystems for Neutron Capture Therapy in Cancer Treatment". Cells 11, n.º 24 (13 de dezembro de 2022): 4029. http://dx.doi.org/10.3390/cells11244029.

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Boron neutron capture therapy is a low-invasive cancer therapy based on the neutron fission process that occurs upon thermal neutron irradiation of 10B-containing compounds; this process causes the release of alpha particles that selectively damage cancer cells. Although several clinical studies involving mercaptoundecahydro-closo-dodecaborate and the boronophenylalanine–fructose complex are currently ongoing, the success of this promising anticancer therapy is hampered by the lack of appropriate drug delivery systems to selectively carry therapeutic concentrations of boron atoms to cancer tissues, allowing prolonged boron retention therein and avoiding the damage of healthy tissues. To achieve these goals, numerous research groups have explored the possibility to formulate nanoparticulate systems for boron delivery. In this review. we report the newest developments on boron vehiculating drug delivery systems based on nanoparticles, distinguished on the basis of the type of carrier used, with a specific focus on the formulation aspects.

35

Minoru, SUZUKI. "New Application for Boron Neutron Capture Therapy". RADIOISOTOPES 64, n.º 1 (2015): 59–66. http://dx.doi.org/10.3769/radioisotopes.64.59.

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36

Maulana, Indra. "ANIMATION OF BORON NEUTRON CAPTURE CANCER THERAPY". Indonesian Journal of Physics and Nuclear Applications 3, n.º 3 (22 de dezembro de 2018): 102–12. http://dx.doi.org/10.24246/ijpna.v3i3.102-112.

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One of the most common causes of death in the world is cancer. Scientists have been trying to find the best cure for cancer ever since it was discovered. There are some ways that are used to treat cancer patients. Lately, scientists have developed a new way in treating cancer, it’s called Boron Neutron Capture Therapy (BNCT). BNCT is a selective cancer therapy, it only selects the cancer cells to be treated and leaves the normal cell untouched. It may have no effect or only a little effect on normal cells. As new knowledge that needs to be known by all people, what is the best way to introduce BNCT? What is the best media to introduce BNCT? Is it enough to just read it in a newspaper or in a book? How about using advanced technology such as animation to introduce BNCT? The use of animation as a form of media to introduce something new is already being done in many fields. Can animation be used as a form of media to introduce BNCT too? Will it be effective? By this study, the author gives information about the effect of using animation as a tool to explain and understand BNCT more.

37

Kanygin, V. V., E. L. Zavyalov, A. E. Simonovich, A. I. Kichigin, A. I. Kasatova, R. A. Mukhamadiyarov, R. V. Sibirtsev, N. S. Filin e T. V. Sycheva. "BORON NEUTRON CAPTURE THERAPY OF GLIAL TUMORS". Современные проблемы науки и образования (Modern Problems of Science and Education), n.º 3 2019 (2019): 144. http://dx.doi.org/10.17513/spno.28914.

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38

Akan, Zafer. "Boron Neutron Capture Therapy for Breast Cancer". International Journal of Women's Health and Reproduction Sciences 3, n.º 2 (7 de fevereiro de 2015): 77. http://dx.doi.org/10.15296/ijwhr.2015.14.

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39

Carlsson, Jorgen, Stefan Sjoberg e Bengt S. Larsson. "Present Status of Boron Neutron Capture Therapy". Acta Oncologica 31, n.º 8 (janeiro de 1992): 803–13. http://dx.doi.org/10.3109/02841869209089712.

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40

Kabalka, George W. "Recent developments in boron neutron capture therapy". Expert Opinion on Therapeutic Patents 8, n.º 5 (maio de 1998): 545–51. http://dx.doi.org/10.1517/13543776.8.5.545.

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41

Raaijmakers, C. P. J., E. L. Nottelman, B. J. Mijnheer e E. L. Nottelman. "Phantom materials for boron neutron capture therapy". Physics in Medicine and Biology 45, n.º 8 (25 de julho de 2000): 2353–61. http://dx.doi.org/10.1088/0031-9155/45/8/320.

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42

Walker, Simon J. "Boron neutron capture therapy: principles and prospects". Radiography 4, n.º 3 (agosto de 1998): 211–19. http://dx.doi.org/10.1016/s1078-8174(98)80048-5.

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43

Carlsson, Jörgen, Erika Bohl Kullberg, Jacek Capala, Stefan Sjöberg, Katarina Edwards e Lars Gedda. "Ligand liposomes and boron neutron capture therapy". Journal of Neuro-oncology 62, n.º 1-2 (março de 2003): 47–59. http://dx.doi.org/10.1007/bf02699933.

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44

Gupta, Nilendu, Reinhard A. Gahbauer, Thomas E. Blue e André Wambersie. "Dose prescription in boron neutron capture therapy". International Journal of Radiation Oncology*Biology*Physics 28, n.º 5 (março de 1994): 1157–66. http://dx.doi.org/10.1016/0360-3016(94)90490-1.

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45

Diaz, Aidnag Z., Jeffrey A. Coderre, Arjun D. Chanana e Ruimei Ma. "Boron neutron capture therapy for malignant gliomas". Annals of Medicine 32, n.º 1 (janeiro de 2000): 81–85. http://dx.doi.org/10.3109/07853890008995913.

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46

Rij, Catharina M. van, Abraham J. Wilhelm, Wolfgang A. G. Sauerwein e Arie C. van Loenen. "Boron neutron capture therapy for glioblastoma multiforme". Pharmacy World & Science 27, n.º 2 (abril de 2005): 92–95. http://dx.doi.org/10.1007/s11096-004-2850-7.

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47

Pitto-Barry, Anaïs. "Polymers and boron neutron capture therapy (BNCT): a potent combination". Polymer Chemistry 12, n.º 14 (2021): 2035–44. http://dx.doi.org/10.1039/d0py01392g.

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48

Mirzaei, Hamed, HamidReza Mirzaei, Amirhossein Sahebkar, Rasoul Salehi, JavidSadri Nahand, Ehsan Karimi e MahmoudReza Jaafari. "Boron neutron capture therapy: Moving toward targeted cancer therapy". Journal of Cancer Research and Therapeutics 12, n.º 2 (2016): 520. http://dx.doi.org/10.4103/0973-1482.176167.

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49

Bortolussi, Silva, Yuan-Hao Liu e Ignacio Porras. "Boron Neutron Capture Therapy: From Nuclear Physics to Biomedicine". Biology 10, n.º 5 (26 de abril de 2021): 370. http://dx.doi.org/10.3390/biology10050370.

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Pramusinta, Rawi, Rawi Pramusinta, R. Zailani e Yohannes Sardjono. "Dose Analysis in Boron Neutron-capture Cancer Therapy (BNCT) Neutron Generator Based for Breast Cancer". Indonesian Journal of Physics and Nuclear Applications 4, n.º 1 (14 de agosto de 2019): 8–11. http://dx.doi.org/10.24246/ijpna.v4i1.8-11.

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Resumo:

The purpose of this study is to know the concentration of boron and irradiation times which optimizes the treatment of breast cancer using the BNCT method. This research was conducted by using MCNPX simulation which outputs are flux neutron, neutron scattering dose and gamma dose. The neutron source used is the BSA D-D Neutron generator model. The independent variable of this research is the boron concentration injected into the cancer. The dependent variable is the total dose rate and irradiation time which determines the effectiveness of BNCT therapy. The controlled variables are the output of the neutron flux, dose and gamma neutron scattering dose. The results showed that in the range of 70-150 µg/g, the dose rate received by cancer increases with increasing the concentration of boron-10. If the dose rate is increased, the irradiation time interval will be faster. The Boron dose of 70 μg/g and the dose rate of irradiation 0.00293603 Gy/sec needs an irradiation time of 409.43 minutes; the boron dose of 90 µg/g and the dose rate of irradiation 0.00241049 Gy/sec needs an irradiation time of 345.71 minutes; the boron dose of 110 µg/g and the dose rate of irradiation 0.00271236 Gy/sec needs an irradiation time of 307.24 minutes; the boron dose of 130 µg/g and the dose rate of irradiation 0.00303389 Gy/sec needs an irradiation time of 274.67 minutes; and the boron dose 150 µg/g and the dose rate of irradiation 0.00334565 Gy/sec needs an irradiation time of 249.08 minutes. The Optimum concentration of boron is 150 µg/g with irradiation time of 249.08 minutes.

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