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Artigos de revistas sobre o assunto "Boron-neutron capture therapy"
Taskaev, S. Yu. "Boron Neutron Capture Therapy". Physics of Atomic Nuclei 84, n.º 2 (março de 2021): 207–11. http://dx.doi.org/10.1134/s106377882101021x.
Texto completo da fonteONO, Koji, Minoru SUZUKI, Shinichiro MASUNAGA, Natsuko KONDO, Yoshinori SAKURAI, Hiroki TANAKA, Yuko KINASHI e Akira MARUHASHI. "Boron Neutron Capture Therapy". RADIOISOTOPES 61, n.º 4 (2012): 209–22. http://dx.doi.org/10.3769/radioisotopes.61.209.
Texto completo da fonteFREEMANTLE, MICHAEL. "BORON NEUTRON CAPTURE THERAPY". Chemical & Engineering News 80, n.º 34 (26 de agosto de 2002): 13. http://dx.doi.org/10.1021/cen-v080n034.p013.
Texto completo da fonteBeddoe, A. H. "Boron neutron capture therapy." British Journal of Radiology 70, n.º 835 (julho de 1997): 665–67. http://dx.doi.org/10.1259/bjr.70.835.9245876.
Texto completo da fonteSlatkin, Daniel N. "Boron neutron-capture therapy". Neutron News 1, n.º 4 (janeiro de 1990): 25–28. http://dx.doi.org/10.1080/10448639008229357.
Texto completo da fonteOta, Ichiro, e Tadashi Kitahara. "Boron Neutron Capture Therapy (BNCT)". Practica Oto-Rhino-Laryngologica 107, n.º 12 (2014): 937–46. http://dx.doi.org/10.5631/jibirin.107.937.
Texto completo da fonte&NA;. "Improving boron neutron capture therapy". Inpharma Weekly &NA;, n.º 971 (janeiro de 1995): 8. http://dx.doi.org/10.2165/00128413-199509710-00016.
Texto completo da fonteMumot, M. "325. Boron Neutron Capture Therapy". Reports of Practical Oncology & Radiotherapy 8 (2003): S354—S355. http://dx.doi.org/10.1016/s1507-1367(03)70808-6.
Texto completo da fonteKato, I. "S17.1 Boron neutron capture therapy". Oral Oncology Supplement 1, n.º 1 (janeiro de 2005): 63. http://dx.doi.org/10.1016/s1744-7895(05)80118-x.
Texto completo da fonteMonti, V., M. Costa, E. Durisi, E. Mafucci, A. Calamida, A. I. Castro Campoy, A. Fontanilla, L. Russo e R. Bedogni. "Neutron spectroscopy for Boron Neutron Capture Therapy beams characterization". Journal of Instrumentation 19, n.º 05 (1 de maio de 2024): C05036. http://dx.doi.org/10.1088/1748-0221/19/05/c05036.
Texto completo da fonteTeses / dissertações sobre o assunto "Boron-neutron capture therapy"
Howard, William Bruce. "Accelerator-based boron neutron capture therapy". Thesis, Massachusetts Institute of Technology, 1997. http://hdl.handle.net/1721.1/44479.
Texto completo da fonteHefne, Jameel. "Neutron spectrum measurement for Boron Neutron Capture Therapy". Diss., Georgia Institute of Technology, 1996. http://hdl.handle.net/1853/16625.
Texto completo da fonteGoorley, John Timothy 1974. "Boron neutron capture therapy treatment planning improvements". Thesis, Massachusetts Institute of Technology, 1998. http://hdl.handle.net/1721.1/49670.
Texto completo da fonteIncludes bibliographical references.
The Boron Neutron Capture Therapy (BNCT) treatment planning process of the Harvard/MIT team used for their clinical Phase I trials is very time consuming. If BNCT proves to be a successful treatment, this process must be made more efficient. Since the Monte Carlo treatment planning calculations were the most time consuming aspect of the treatment planning process, requiring more than thirty six hours for scoping calculations of three to five beams and final calculations for two beams, it was targeted for improvement. Three approaches were used to reduce the calculation times. A statistical uncertainty analysis was performed on doses rates and showed that a fewer number of particles could not be used and still meet uncertainty requirements in the region of interest. Unused features were removed and assumptions specific to the Harvard/MIT BNCT treatment planning calculations were hard wired into MCNP by Los Alamos personnel, resulting in a thirty percent decrease in runtimes. MCNP was also installed in parallel on the treatment planning computers, allowing a factor of improvement by roughly the number of computers linked together in parallel. After theses enhancements were made, the final executable, MCNPBNCT, was tested by comparing its calculated dose rates against the previously used executable, MCNPNEHD. Since the dose rates in close agreement, MCNPBNCT was adopted. The final runtime improvement to a single beam scoping run by linking the two 200MHz Pentium Pro computers was to reduce the wall clock runtime from 2 hours thirty minutes to fifty nine minutes. It is anticipated that the addition of ten 900 MHz CPUs will further reduce this calculation to three minutes, giving the medical physicist or radiation oncologist the freedom to use an iterative approach to try different radiation beam orientations to optimize treatment. Additional aspects of the treatment planning process were improved. The previously unrecognized phenomenon of peak dose movement during irradiation and its potential for overdosing the subject was identified. A method of predicting its occurrence was developed to prevent this from occurring. The calculated dose rate was also used to create dose volume histograms and volume averaged doses. These data suggest an alternative method for categorizing the subjects, rather than by peak tissue dose.
by John Timothy Goorley.
S.M.
Matalka, Khalid Zuhair. "Boron neutron capture therapy of brain tumors /". The Ohio State University, 1992. http://rave.ohiolink.edu/etdc/view?acc_num=osu148778039326795.
Texto completo da fonteGuidi, Claretta. "Sviluppo e applicazioni della boron neutron capture therapy". Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2017. http://amslaurea.unibo.it/13399/.
Texto completo da fonteShah, Jungal (Jugal Kaushik). "Hypoxia-selective compounds for boron neutron capture therapy". Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/44829.
Texto completo da fonte"June 2008."
Includes bibliographical references.
Boron neutron capture therapy (BNCT) is a biochemically targeted form of radiotherapy for cancer. In BNCT, a compound labeled with the stable isotope boron-10 is systemically administered, and tumor cells selectively uptake the boron-10 containing compound at higher concentrations than normal cells. A general problem with the tumor seeking compounds is that drug delivery is dependent upon sufficient vascularization within the tumor. To investigate the possibility of delivering boron to hypoxic regions of tumor, a new boronated nitroimidazole delivery agent has been synthesized as a carrier of boron-10 for BNCT. It is expected that this will be used in combination with the existing boron carrier boronophenylalanine-fructose to treat solid tumors. An immunohistochemical protocol to visualize hypoxia was tested and refined to confirm the suitability of two tumor models established in the lab for hypoxia related uptake studies. The immunohistochemical protocol is used to detect pimonidazole, which localizes at hypoxic regions in tissue and is the parent compound for the new hypoxia-selective boron carrier. The protocol was used to test and confirm the suitability of a hypoxic in vivo tumor model. Two tumor lines were tested: SCCVII squamous cell carcinoma and EMT-6 murine mammary carcinoma. Both exhibited hypoxia. Finally, quantitative studies using Inductive Coupled Plasma Atomic Emission Spectrum demonstrated that the synthesized boronated nitroimidazole reaches suitable concentrations in SCCVII and F98 tumor. Future therapeutic studies are required to empirically confirm the effectiveness of this compound.
by Jugal Shah.
S.B.
Wang, Zhonglu. "Design of a Boron Neutron Capture Enhanced Fast Neutron Therapy Assembly". Diss., Georgia Institute of Technology, 2006. http://hdl.handle.net/1853/14100.
Texto completo da fonteSweezy, Jeremy Ed. "Development of a boron neutron capture enhanced fast neutron therapy beam". Diss., Georgia Institute of Technology, 2002. http://hdl.handle.net/1853/17107.
Texto completo da fonteKudchadker, Rajat. "Optimized accelerator based epithermal neutron beams for boron neutron capture therapy /". free to MU campus, to others for purchase, 1996. http://wwwlib.umi.com/cr/mo/fullcit?p9821332.
Texto completo da fonteChung, Yoonsun. "Radiobiological evaluation of new boron delivery agents for boron neutron capture therapy". Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/44784.
Texto completo da fonteIncludes bibliographical references (p. 123-132).
This thesis evaluates the radiobiological effectiveness of three new boron compounds namely a boronated porphyrin (BOPP) and two liposome formulations for neutron capture therapy (BNCT). The methodology utilizes in vitro and in vivo comparisons that characterize compounds relative to boric acid and boronophenylalanine (BPA). In vitro evaluations utilized a colorimetric assay and 96-well plates to minimize the quantities of compound required for testing. The assay was optimized for the murine SCCVII, squamous cell carcinoma to determine the chemical toxicity and relative cellular uptake of a compound. BOPP was toxic at low concentrations and comparisons between the different compounds for thermal neutron irradiations were performed with approximately 5 [mu]g 10B/ml in the culture medium to allow radiation induced effects to govern the observed response. Using less than 300 [mu]g of compound and 250 kVp X-rays as control irradiations, a compound biological effectiveness (CBE) of 3.3 ± 0.7 was determined for BOPP that is comparable to the result for boric acid (3.5 ± 0.5) indicating a non-selective intracellular accumulation of 10B. BPA has a significantly higher CBE of 6.1 + 0.7. Boronated liposomes (MAC-16 and MAC+TAC) were evaluated with the EMT-6 murine mammary carcinoma. Biodistribution studies showed high 10B uptake in tumor (20-40 [mu]g 10B/g) 30 hours after a single i.v. injection (dose 6-20 [mu]g 10B per gram of body weight). Tumor control experiments were performed using thermal neutrons to study the efficacy of the boron delivered by liposomes and BPA. The MAC-16 produced a 16 % tumor control and BPA (dose 43 [mu]g 10B/gbw) 63 % for tumor boron concentrations of approximately 20 [mu]g 10B/g and the same neutron fluence.
(cont.) Liposome doses were limited by injection volume and so two injections were tried 2-hours apart that doubled the boron concentration in tumor compared to a single administration. This improved the therapeutic response to 67 % with less apparent skin damage than with BPA. Microscopic studies using fluorescent labeled liposomes revealed 10B was nonuniformly distributed and concentrated at the edge of the tumor. Based on these studies in the tumor cell lines chosen neither of the compounds appear superior to BPA.
by Yoonsun Chung.
Ph.D.
Livros sobre o assunto "Boron-neutron capture therapy"
Gabel, Detlef, e Ray Moss, eds. Boron Neutron Capture Therapy. Boston, MA: Springer US, 1992. http://dx.doi.org/10.1007/978-1-4615-3408-2.
Texto completo da fonte1932-, Hatanaka Hiroshi, ed. Boron-neutron capture therapy for tumors. Niigata, Japan: Nishimura, 1986.
Encontre o texto completo da fonte1929-, Mishima Yutaka, e International Symposium on Neutron Capture Therapy (6th : 1994 : Kōbe-shi, Japan), eds. Cancer neutron capture therapy. New York: Plenum Press, 1996.
Encontre o texto completo da fonteNievaart, Victor Alexander. Spectral tailoring for boron neutron capture therapy. Amsterdam: IOS Press, 2007.
Encontre o texto completo da fonteH, Soloway Albert, Barth Rolf F, Carpenter David E. 1943-, International Society for Neutron Capture Therapy., International Union against Cancer, Arthur G. James Cancer Hospital and Research Institute. e International Symposium on Neutron Capture Therapy (5th : 1992 : Columbus, Ohio), eds. Advances in neutron capture therapy. New York: Plenum Press, 1993.
Encontre o texto completo da fonteRoss, David Ian. Various studies relating to boron neutron capture therapy. Birmingham: University of Birmingham, 1992.
Encontre o texto completo da fonteBörje, Larsson, Crawford John e Weinreich Regin, eds. Advances in neutron capture therapy: Proceedings of the Seventh International Symposium on Neutron Capture Therapy for Cancer, Zürich, Switzerland, 4-7 September 1996. Amsterdam: Elsevier, 1997.
Encontre o texto completo da fonteHosmane, Narayan S. Boron and gadolinium neutron capture therapy for cancer treatment. Singapore: World Scientific, 2012.
Encontre o texto completo da fonteG, Fairchild Ralph, Bond Victor P e Woodhead Avril D, eds. Clinical aspects of neutron capture therapy. New York: Plenum Press, 1989.
Encontre o texto completo da fonteNational Cancer Institute (U.S.). Division of Cancer Treatment. Radiation Research Program e Boron Workshop (1988 : Annapolis, Md.), eds. Boron compounds suitable for neutron capture therapy for the treatment of cancer. [Bethesda, MD: The Program, 1988.
Encontre o texto completo da fonteCapítulos de livros sobre o assunto "Boron-neutron capture therapy"
Yanch, Jacquelyn C. "Boron Neutron Capture Synovectomy". In Neutron Capture Therapy, 521–30. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-31334-9_31.
Texto completo da fonteNakagawa, Yoshinobu. "Boron Neutron Capture Therapy". In Frontiers in Neutron Capture Therapy, 73–79. Boston, MA: Springer US, 2001. http://dx.doi.org/10.1007/978-1-4615-1285-1_6.
Texto completo da fontePerks, Christopher A., e Howard J. Delafield. "Neutron Spectrometry Measurements of the Petten HFR, HB11 Neutron Beam". In Boron Neutron Capture Therapy, 79–91. Boston, MA: Springer US, 1992. http://dx.doi.org/10.1007/978-1-4615-3408-2_10.
Texto completo da fonteMauri, Pier Luigi, e Fabrizio Basilico. "Proteomic Investigations for Boron Neutron Capture Therapy". In Neutron Capture Therapy, 189–200. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-31334-9_10.
Texto completo da fonteKawabata, Shinji, e Shin-Ichi Miyatake. "Boron Neutron Capture Therapy for Malignant Meningiomas". In Neutron Capture Therapy, 399–406. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-31334-9_22.
Texto completo da fonteHondros, E. D. "Opening Speech". In Boron Neutron Capture Therapy, 1–3. Boston, MA: Springer US, 1992. http://dx.doi.org/10.1007/978-1-4615-3408-2_1.
Texto completo da fonteRaaijmakers, Cornelis P. J., Luc Dewit, Mark W. Konijnenberg, Ben J. Mijnheer, Raymond L. Moss e Finn Stecher-Rasmussen. "A Semi-Empirical Method of Treatment Planning for Boron Neutron Capture Therapy". In Boron Neutron Capture Therapy, 93–100. Boston, MA: Springer US, 1992. http://dx.doi.org/10.1007/978-1-4615-3408-2_11.
Texto completo da fonteWatkins, Peter. "Present Status of the Three-Dimensional Treatment Planning Methodologies for the Petten BNCT Facility". In Boron Neutron Capture Therapy, 101–9. Boston, MA: Springer US, 1992. http://dx.doi.org/10.1007/978-1-4615-3408-2_12.
Texto completo da fonteCoderre, Jeffrey A. "A Phase 1 Biodistribution Study of p-Boronophenylalanine". In Boron Neutron Capture Therapy, 111–21. Boston, MA: Springer US, 1992. http://dx.doi.org/10.1007/978-1-4615-3408-2_13.
Texto completo da fonteGahbauer, Reinhard A., Ralph G. Fairchild, Joseph H. Goodman e Thomas E. Blue. "RBE in Normal Tissue Studies". In Boron Neutron Capture Therapy, 123–28. Boston, MA: Springer US, 1992. http://dx.doi.org/10.1007/978-1-4615-3408-2_14.
Texto completo da fonteTrabalhos de conferências sobre o assunto "Boron-neutron capture therapy"
Stecher‐Rasmussen, F., R. L. Moss e M. W. Konijnenberg. "Boron Neutron Capture Therapy". In Capture gamma‐ray spectroscopy. American Institute of Physics, 1991. http://dx.doi.org/10.1063/1.41154.
Texto completo da fonteHaque, A. M., G. Moschini, Vlado Valkovic e D. Zafiropoulos. "Boron-neutron capture therapy". In 4th International Conference on Applications of Nuclear Techniques: Neutrons and their Applications, editado por George Vourvopoulos e Themis Paradellis. SPIE, 1995. http://dx.doi.org/10.1117/12.204194.
Texto completo da fonteGabel, Detlef. "Boron neutron capture therapy: from physics to treatment". In Fifth International Conference on Applications of Nuclear Techniques: Neutrons in Research and Industry, editado por George Vourvopoulos. SPIE, 1997. http://dx.doi.org/10.1117/12.267842.
Texto completo da fonteKanda, Keiji. "Experience of boron neutron capture therapy in Japan". In Fifth International Conference on Applications of Nuclear Techniques: Neutrons in Research and Industry, editado por George Vourvopoulos. SPIE, 1997. http://dx.doi.org/10.1117/12.267900.
Texto completo da fonteTaskaev, Sergey. "Neutron source VITA for Boron Neutron Capture Therapy and other applications". In RAD Conference. RAD Centre, 2021. http://dx.doi.org/10.21175/rad.abstr.book.2021.16.2.
Texto completo da fonteHerrera, María S., Sara J. González, Daniel M. Minsky, Andrés J. Kreiner, Ricardo Alarcon, Phil Cole, Andres J. Kreiner e Hugo F. Arellano. "Treatment Planning for Accelerator-Based Boron Neutron Capture Therapy". In VIII LATIN AMERICAN SYMPOSIUM ON NUCLEAR PHYSICS AND APPLICATIONS. AIP, 2010. http://dx.doi.org/10.1063/1.3480233.
Texto completo da fonteShefer, Ruth E., Robert E. Klinkowstein e Jacquelyn C. Yanch. "High-current electrostatic accelerator for boron neutron capture therapy". In Fifth International Conference on Applications of Nuclear Techniques: Neutrons in Research and Industry, editado por George Vourvopoulos. SPIE, 1997. http://dx.doi.org/10.1117/12.267922.
Texto completo da fonteYanch, J. C., R. E. Shefer, R. E. Klinkowstein, W. B. Howard, H. Song, B. Blackburn e E. Binello. "Research in Boron Neutron Capture Therapy at MIT LABA". In The fourteenth international conference on the application of accelerators in research and industry. AIP, 1997. http://dx.doi.org/10.1063/1.52637.
Texto completo da fonteSingh, Bikramjeet, Paviter Singh, Manjeet Kumar, Anup Thakur e Akshay Kumar. "Single step synthesis of nanostructured boron nitride for boron neutron capture therapy". In PROCEEDINGS OF THE INTERNATIONAL CONFERENCE ON CONDENSED MATTER PHYSICS 2014 (ICCMP 2014). AIP Publishing LLC, 2015. http://dx.doi.org/10.1063/1.4915415.
Texto completo da fonteKanygin, V. V., A. I. Kichigin, A. L. Krivoshapkin e S. Yu Taskaev. "Perspectives of boron-neutron capture therapy of malignant brain tumors". In PHYSICS OF CANCER: INTERDISCIPLINARY PROBLEMS AND CLINICAL APPLICATIONS: Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications (PC IPCA’17). Author(s), 2017. http://dx.doi.org/10.1063/1.5001609.
Texto completo da fonteRelatórios de organizações sobre o assunto "Boron-neutron capture therapy"
Maughan, R. L., e C. Kota. Microdosimetry for Boron Neutron Capture Therapy. Office of Scientific and Technical Information (OSTI), setembro de 2000. http://dx.doi.org/10.2172/770637.
Texto completo da fonteN. Commercial Clinical Application of Boron Neutron Capture Therapy. Office of Scientific and Technical Information (OSTI), setembro de 1999. http://dx.doi.org/10.2172/942161.
Texto completo da fonteDolan, T., E. Ottewitte, E. Wills, W. Neuman e D. Woodall. Non-reactor neutron sources for BNCT (Boron Neutron Capture Therapy). Office of Scientific and Technical Information (OSTI), maio de 1989. http://dx.doi.org/10.2172/5876401.
Texto completo da fonteWang, Zhonglu. Design of a boron neutron capture enhanced fast neutron therapy assembly. Office of Scientific and Technical Information (OSTI), dezembro de 2006. http://dx.doi.org/10.2172/892403.
Texto completo da fonteSweezy, Jeremy Ed. Development of a Boron Neutron Capture Enhanced Fast Neutron Therapy Beam. Office of Scientific and Technical Information (OSTI), janeiro de 2002. http://dx.doi.org/10.2172/1420958.
Texto completo da fonteJ. Vujic, E. Greenspan, W.E. Kastenber, Y. Karni, D. Regev, K. N. Leung J.M. Verbeke, D. Chivers et al. Optimal Neutron Source & Beam Shaping Assembly for Boron Neutron Capture Therapy. Office of Scientific and Technical Information (OSTI), abril de 2003. http://dx.doi.org/10.2172/810841.
Texto completo da fonteBarnum, Beverly A., Yan Hao, Roger Moore, M. Frederick Hawthorne e Kurt Baum. Carborane derivative development for boron neutron capture therapy. Final report. Office of Scientific and Technical Information (OSTI), abril de 1999. http://dx.doi.org/10.2172/762720.
Texto completo da fonteDorn, R. V. III. Power Burst Facility/Boron Neutron Capture Therapy Program for cancer treatment. Editado por A. L. Ackermann. Office of Scientific and Technical Information (OSTI), agosto de 1990. http://dx.doi.org/10.2172/6321857.
Texto completo da fonteAckermann, A. L., ed. Power Burst Facility/Boron Neutron Capture Therapy Program for cancer treatment. Office of Scientific and Technical Information (OSTI), outubro de 1990. http://dx.doi.org/10.2172/6141929.
Texto completo da fonteDorn, R. V. III. Power Burst Facility/Boron Neutron Capture Therapy Program for cancer treatment. Editado por A. L. Ackermann. Office of Scientific and Technical Information (OSTI), setembro de 1990. http://dx.doi.org/10.2172/6168994.
Texto completo da fonte