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Bibliografias temáticas / Blood disorder

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Literatura científica selecionada sobre o tema "Blood disorder"

Autor: Grafiati

Publicado: 4 de junho de 2021

Última modificação: 30 de janeiro de 2023

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Artigos de revistas sobre o assunto "Blood disorder"

1

Khan, KausarRehman. "Thalassemia: Genetically transmitted blood disorder". Acta Medica International 2, n.º 2 (2015): 195. http://dx.doi.org/10.5530/ami.2015.5.7.

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Zonda, Tamas, e David Lester. "Blood Type and Bipolar Disorder". Perceptual and Motor Skills 95, n.º 3 (dezembro de 2002): 988. http://dx.doi.org/10.2466/pms.2002.95.3.988.

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3

SAITO, HIDEHIKO. "Blood coagulation disorder Thrombotic tendency." Nihon Naika Gakkai Zasshi 88, n.º 9 (1999): 1668–78. http://dx.doi.org/10.2169/naika.88.1668.

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4

Coghlan, Andy. "Gene therapy cures blood disorder". New Scientist 207, n.º 2778 (setembro de 2010): 12. http://dx.doi.org/10.1016/s0262-4079(10)62249-x.

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5

Godara, Amandeep, Nauman Siddiqui, Zarmina Khan, Ankit Kansagra, Jean Yared e Saurabh Dahiya. "Blood and Blues: Prevalence of Mental Health Disorders in Patients Hospitalized with Acute Leukemia". Blood 132, Supplement 1 (29 de novembro de 2018): 4871. http://dx.doi.org/10.1182/blood-2018-99-120239.

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Abstract Introduction: Approximately 1.5% of population will be diagnosed with leukemia in their lifetime (SEER Cancer Statistics Review). Diagnosis of acute leukemia has an overwhelming effect on the patient and their families. Besides the diagnosis, effect of chemotherapeutic agents and agony over the ultimate outcome can also affect emotional-behavioral wellbeing. Evolution of depression as a disorder, along the course of acute leukemia has been reported in the past (David et al Procedia Soc & Behav Sci 2014). We investigated the prevalence of mental health disorders in hospitalized patients admitted with acute leukemia diagnosis utilizing Healthcare Utilization Project National Inpatient Sample (HCUP NIS), 2002-2014. HCUP-NIS is the largest publicly available all-payer inpatient health care database in the United States, and is a 20% stratified sample of all hospital discharges. Methods: We identified hospitalizations for acute leukemia using ICD-9 codes (203.XX, 204.XX, 205.XX, 206.XX, 207.XX and 208.XX) in the NIS database. We included patients with a primary diagnosis of acute leukemia (myeloid, lymphoid and plasma cell leukemia) including admissions for inpatient chemotherapy and/or complications requiring hospitalization. Similarly, ICD-9 codes were used to identify patients with mental health disorders of interest (ADHD, adjustment disorder, alcohol abuse, anxiety disorder, mood disorders, personality disorders, schizophrenia, substance abuse, childhood disorders). "Surveyfreq" was used to calculate proportions while "Surveymeans" was used to calculate median length of stay and hospital charges. Cochran-Armitage test was used to analyze trends; Kruskal-Wallis test was used for non-parametric data. We used chi-square for categorical data frequency, P value of < 0.05 was considered statistically significant. All analysis was performed using SAS 9.4. Results: We identified a total of 59,223 patients with mental health disorders (18.4%) out of a total of 321223 hospitalizations for acute leukemia (table 1). Median age for patients with mental health disorders is 56 years. Mood disorder was most prevalent at 8% followed by anxiety disorder at 6%. Within all mental disorders, mood disorders comprised 44% of all cases followed by anxiety disorder at 32% (figure 1). Over 60% of mental health disorders were in patient age group above 50 years (figure 2). Prevalence of mental health disorders has increased from 10% to 28% between 2002 and 2014 (figure 3). Prevalence of anxiety disorder has increased 6 fold between 2002 (2%) and 2014 (12%). It is unclear if this change is due to an actual increase in the prevalence of this condition or better recognition of mental health disorders leading to better coding. Median length of stay (LOS) is significantly longer in patients with mental health disorders compared to those without (18 days vs 9 days respectively). Median charges for hospitalization are also significantly increased in patients with mental health disorders than those without ($119,245 vs $62,132 respectively). Conclusion: Mental health disorders are common in patients with acute leukemia. One in four patients (28%) in 2014 had a mental health disorder compared to 9% in 2002. Given the retrospective nature of our study, it is difficult to determine if this is an actual increase in the incidence and prevalence of mental health disorders or if better recognition and medical coding contributes to this finding. Our study shows a disproportionate burden of mental health disorders in patients above the age 50, which constitutes the majority of the patients diagnosed with acute leukemia. Use of mental health screening tools in this population could provide an avenue for recognition and possible early intervention. Given the retrospective nature of our study, these findings need to be validated in a prospective patient population. Disclosures No relevant conflicts of interest to declare.

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Fedoseyeva, I. F., T. V. Poponnikova e A. V. Veremeyev. "Noradrenaline state in children with a tic disorders". Bulletin of Siberian Medicine 8, n.º 1(2) (28 de fevereiro de 2009): 87–89. http://dx.doi.org/10.20538/1682-0363-2009-1(2)-87-89.

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The content of noradrenaline in blood serum in 28 children 6–16 years of age with tic disorder was analyzed. It was detected reliable descent the content of noradrenaline in blood serum of the children with a tic disorders compared the group of healthy children. Authors suppose that metabolism of noradrenaline takes part in pathogenesis of tic disorder, emotional and behavioral disorders.

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7

Means, Robert T. "Pure red cell aplasia". Blood 128, n.º 21 (24 de novembro de 2016): 2504–9. http://dx.doi.org/10.1182/blood-2016-05-717140.

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Abstract Pure red cell aplasia (PRCA) is a syndrome defined by a normocytic normochromic anemia with severe reticulocytopenia and marked reduction or absence of erythroid precursors from the bone marrow. Diamond-Blackfan anemia is a congenital form of PRCA. Acquired PRCA may be either a primary disorder or secondary to some other disorder or agent. Primary acquired PRCA is an autoimmune disorder that is frequently antibody-mediated. Myelodysplastic syndromes may also present with the morphologic appearance of PRCA. Secondary acquired PRCA may be associated with collagen vascular/autoimmune disorders such as systemic lupus erythematosus; lymphoproliferative disorders such as chronic lymphocytic leukemia or large granular lymphocyte leukemia; infections, particularly B19 parvovirus; thymoma and other solid tumors; or a variety of other disorders, drugs, or toxic agents. The therapeutic approach to PRCA typically involves immunosuppression, but specific pathogenic subtypes are associated with specific therapeutic approaches. Cyclosporine A, with or without concurrent corticosteroids, appears to be the single most effective immunosuppressive agent.

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8

Nair, Arun B. "Proportion of Raised Blood Pressure and Raised Blood Sugar Level in Newly Diagnosed Attention Deficit Hyperactivity Disorder in Children". Journal of Medical Science And clinical Research 05, n.º 03 (23 de maio de 2017): 19260–66. http://dx.doi.org/10.18535/jmscr/v5i3.150.

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9

Romanenko, S. Yu, K. V. Vilchevska, I. O. Bakhchivandzhi e Yu V. Martinenko. "A rare disorder of blood coagulation". Modern pediatrics. Ukraine, n.º 6(126) (29 de outubro de 2022): 97–100. http://dx.doi.org/10.15574/sp.2022.126.97.

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The problem of impaired hemostasis remains relevant even today. Rare bleeding disorders that cause life-threatening bleeding in patient are often overlooked by clinicians. Rare blood coagulation disorders are a genetically determined group of coagulopathies caused by a deficiency of blood plasma proteins involved in hemostasis, as well as a deficiency of fibrinogen, prothrombin, blood coagulation factor V (FV), blood coagulation factors V and VIII (FV+FVIII), blood coagulation factor VII (FVII), blood coagulation factor X (FX), blood coagulation factor XI (FXI), blood coagulation factor XII (FXII), blood coagulation factor XIII (FXIII), which are clinically are manifested by bleeding. The amount of the factor determines not only the nature of bleeding, but also their severity and prognosis for the disease. In such patients, the general hemostatic balance is important, since the level of each blood coagulation factor and the general control of hemostasis, which can determine the risk of bleeding, remain important. Purpose - to draw the attention of doctors of various specialties to the problem of clinical manifestations of rare hereditary disorders of blood coagulation, which can be accompanied by bleeding that poses a threat to the health and life of patient. Clinical case. A clinical case is presented that illustrates the course of a rare blood coagulation disorder in children from one family, where a comprehensive diagnostic search was conducted by doctors of various specialties to establish a final diagnosis. Conclusions. Rare blood coagulation disorders are a pathology that is not often found in the population, but clinical symptoms can have negative consequences for a person's health and life. Children with various manifestations of hemorrhagic syndrome need a thorough diagnostic examination in specialized laboratories. Physicians of related specialties should look for a possible rare deficiency of the coagulation factor in early and late complications in the postoperative period or after medical manipulations. It is necessary to remember the hereditary genesis of this pathology and examine all family members. The research was carried out in accordance with the principles of the Helsinki Declaration. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors.

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Olaiya, Oluwaseun, Zuri Hudson, Eryn Bilynsky, Hung-Wen Yeh e Shannon L. Carpenter. "Bleeding Disorder Referrals to Hematology Clinic: A Single Institution Experience". Blood 136, Supplement 1 (5 de novembro de 2020): 4–5. http://dx.doi.org/10.1182/blood-2020-140552.

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BACKGROUND Our tertiary care pediatric hematology/oncology/BMT service receives hundreds of referrals yearly for bleeding disorder evaluation both due to bleeding symptoms and secondary to routine preoperative laboratory testing prior to elective surgery. The evaluation for a bleeding disorder can be challenging due to the wide variability of symptoms as well as the need for accurate interpretation of lab results. In 2014, Bhasin et al., Pediatric Hematology and Oncology showed that 4% of patients referred to hematology based on a preoperative coagulation evaluation had a clinically relevant bleeding disorder. Currently there is little literature about the referral patterns to pediatric hematology and the outcomes of these referrals. OBJECTIVES To characterize our hematology referrals for bleeding disorder, work up To describe the diagnostic outcomes from these referrals To estimate the proportion of bleeding disorders diagnosed from these referrals To identify referral factors that are associated with being diagnosed with a bleeding disorder DESIGN/METHOD This is a single center, retrospective chart review. Patients referred and or seen for a bleeding disorder evaluation at Children's Mercy Hospital from 07/1/2018 until 06/30/19 were evaluated for demographics, reason for consultation, referring provider, and outcome of referral. Akaike Information Criterion (AIC) was applied to logistic regression to identify factors associated with diagnosis of bleeding disorder. RESULTS A total of 373 patients were included and demographics are detailed in Table 1. Forty patients were diagnosed with a bleeding disorder, 78 patients were lost to follow up or have work up still in progress, and 255 patients had a bleeding disorder ruled out. Of our referred patient sample, 6% (21/373) were diagnosed with von Willebrand disease, 4% (14/373) were diagnosed with a platelet function disorder, and 1.3% (5/373) were diagnosed with a coagulation factor deficiency. The median time between referral and appointment was 31.5 days with a median of 2 total visits including clinic and laboratory visit for a clinical diagnosis. Forty percent of referrals were for preoperative clearance, 36% for family history, and 57% for symptoms. Of the patients referred for symptoms, 22.7% were referred for bruising and 83.9% for bleeding. Thirty eight percent had previously been treated for symptoms through hormone management, nasal cauterization, surgical intervention, or other methods. Forty four percent (164/373) of the referrals were from Otolaryngology, 30% from primary care including adolescent medicine and gynecology, and 27% from other specialties. Seventy percent of referrals were internal from specialties within our institution. The results indicate that the odds of a bleeding disorder diagnosis decrease by 8% for every year increment in age and was 3 times higher among patients having abnormal coagulation labs at the time of referral as compared to their counterpart when other variables were controlled. Logistic regression model showing referral factors that could be associated with bleeding disorder diagnosis are detailed in table 3. CONCLUSION This study characterizes the bleeding disorder referral patterns at our institution including the proportion of bleeding disorders diagnosed. This study also highlighted certain referral factors such as age, gender, referral for preoperative clearance, previous treatment with nasal cauterization and the presence of abnormal lab values that could be predictive of the presence of a bleeding disorder. Limitations of this study include the small number of patients with confirmed diagnosis and that it is conducted at a single center. Additionally, at our center, referrals are screened by a physician prior to being seen, which could have influenced the results. We illustrate that large-scale studies are needed to determine referral factors associated with the diagnosis of a bleeding disorder. Disclosures Carpenter: American Academy of Pediatrics: Other: PREP Heme/Onc editorial board; Hemostasis & Thrombosis Research Society: Membership on an entity's Board of Directors or advisory committees; Shire: Research Funding; CSL Behring: Research Funding; American Thrombosis and Hemostasis Network: Membership on an entity's Board of Directors or advisory committees; Genentech, Inc.: Honoraria; Kedrion: Honoraria; Novo Nordisk: Honoraria.

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Teses / dissertações sobre o assunto "Blood disorder"

1

Neuger, Jolanta. "Platelet serotonin function and personality traits in affective disorder /". Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-181-0.

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2

Newsome, Dominique. "My story, my identity and my relationship with work : sickle cell disorder". Thesis, Canterbury Christ Church University, 2016. http://create.canterbury.ac.uk/14924/.

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This study explored the narratives people living with sickle cell disorder construct to explain how the experience of employment influences their identity and subsequently their quality of life. Nine individuals with sickle cell disorder were interviewed and gave detailed autobiographical narratives which were transcribed and processed using narratives analysis. Participants were 4 men and 5 women aged between 22 and 60 years. Participants' passion for their job roles was illustrated by their positive work identities. Earlier experiences were felt to be influential on drive and resilience to work challenges. In the narratives, poor understanding of sickle cell disorder by organisations and reduced ability to manage their condition impacted physical health; psychological and emotional wellbeing; social and cultural experiences. This study has implications for the clinical practice and future research of adults living with sickle cell disorder, contributing to the broadening general understanding of sickle cell disorder.

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3

Vranish, Jennifer R. "Obstructive Sleep Apnea: Daytime Assessment And Treatment Of A Nighttime Disorder". Diss., The University of Arizona, 2015. http://hdl.handle.net/10150/566239.

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Obstructive sleep apnea (OSA) is a disease characterized by nighttime airflow limitation, hypoxemia, arousal from sleep, and elevated sympathetic activity and blood pressure. With time, this nighttime dysfunction gives rise to daytime hypertension and a heightened risk for cardiovascular disease. Current treatment options for OSA are not always effective for all patients and the gold-standard intervention, continuous positive airway pressure, has discouraging compliance rates. The work set forth in this dissertation has as its focus a novel intervention for sleep apnea known as inspiratory muscle training (IMT). IMT improves respiratory function and cardiovascular health but has not been implemented previously as a treatment for OSA. As such, Study 1 implements IMT in individuals with mild and moderate OSA, with the objective of assessing the effects of training on the cardio- respiratory parameters of this disease. We randomly assigned 24 individuals with mild- moderate OSA into one of two groups: training vs. placebo, to assess the effects of 6 weeks of training on overnight polysomnography, subjective sleep quality, blood pressure, circulating inflammatory T cells, and plasma catecholamine content. Our results show IMT- related improvements in sleep quality, reduction in the number of arousals from sleep and in periodic limb movements following 6 weeks of training. Most important, IMT was associated with a significant reduction in systolic (~12 mmHg) and diastolic (~5 mmHg) blood pressure, relative to sleep apneics who undertook 6 weeks of placebo training. Additionally, individuals in the training group exhibited ~30% lower levels of sympathetic activity, as measured by plasma catecholamines, relative to placebo trained peers. The mechanism(s) that underlie the IMT-related reductions in blood pressure and sympathetic activity remain to be determined. However, in an effort to determine the precise respiratory stimulus that contributes to the results obtained in Study 1, we subsequently assessed the specific respiratory components of IMT to determine which component (large intrathoracic pressures and/or large lung volumes) likely contributes to the reduction in blood pressure in Study 1. The results of this study conducted in normotensive adults show that respiratory training that entails either large negative or positive intrathoracic pressures reduces systolic and diastolic blood pressure in healthy young adults. Importantly, neither the generation of large lung volumes alone nor performance of daily paced breathing is sufficient to lower blood pressure. Study 3 is a methodologic study that has as its focus upper airway electromyography (EMG) and the utility of assessing EMG activity across a range of conditions and breathing tasks in wakefulness. Because OSA traditionally has been viewed as the result of neuromuscular dysfunction of the upper airway that occurs during sleep, the aim of this work was to develop a "fingerprint" of healthy electromyographic activities during the day in healthy adults across a range of breathing tasks, body positions, and from two different muscle compartments of the upper airway. The findings from this study demonstrate regional differences in muscle activity that vary as a function of body position and task. These data from healthy subjects provide the basis of comparison for subsequent studies in individuals with obstructive sleep apnea.

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4

Ewing, Jane Elizabeth. "Support services for adolescents and young adults with cancer or a blood disorder : measurement properties and validation of quality of life instruments for adolescents and young adults with cancer or a blood disorder". University of Technology, Sydney. Faculty of Science, 2006. http://hdl.handle.net/2100/423.

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Health-Related Quality of Life (HRQOL) is an important outcomes measure in cancer and there are specific issues depending on the site, stage, treatment and patient age. Although numerous instruments are available for cancer HRQOL, most are designed for adults, some for children, but none for adolescents and young adults (AYA) who have special age-specific concerns and poor improvement in survival compared with other age groups. An existing HRQOL instrument was modified to ensure its suitability for AYA, its validity, reliability and sensitivity were tested in Australians aged 16 to 25 years old diagnosed with cancer or a blood disorder. Varni’s PedsQLTM Measurement Model (13-18 year olds) was selected, modified then administered to families recruited from haematology/oncology clinics and wards at three Sydney Metropolitan Hospitals in person or by telephone. The Memorial Symptom Assessment Scale was used to categorise participants into groups reflecting sensitivity of symptom severity (slight, moderate and severe). The instruments demonstrated excellent internal consistency reliability, making them suitable for both group and individual comparisons. Clinical validity, construct validity, and discriminant validity were demonstrated by “known-groups” analysis, exploratory factor analysis and correlations, respectively. These new versions of the PedsQL Generic Core and Cancer Module are reliable, valid and sensitive measures of HRQOL in patients aged 16-25 years diagnosed with cancer or a blood disorder. The measures will soon be available for use as outcome measures in clinical trials and clinical practice with this age cohort in Australasia and internationally.

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5

Frans, Örjan. "Posttraumatic Stress Disorder (PTSD) in the General Population". Doctoral thesis, Uppsala University, Department of Psychology, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3528.

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This thesis explored the epidemiology of Posttraumatic Stress Disorder (PTSD) and different aspects of the disorder. Firstly, we investigated the lifetime prevalence of traumatic experiences and PTSD in the general adult population in Sweden and evaluated the impact of different trauma types, trauma frequency, and perceived distress. The results show that traumatic experiences are common and PTSD is not rare; roughly one out of ten traumatic events results in PTSD, with a 5.6% lifetime prevalence. The female/male ratio is 2:1. The risk for PTSD increases considerably with a high trauma-associated emotional impact. The distressing impact of a given trauma appears to be higher in women than in men, indicating an increased vulnerability in women. Secondly, we hypothesized that traffic road accidents (TRA’s) are one of the most prevalent types of traumatic events in Swedish society; therefore, we examined the impact of event and response characteristics associated with TRA’s on PTSD development. The data demonstrate that of those who had experienced a TRA (n=1074, 58.9%), 6.1% reported lifetime PTSD. TRA’s associated with fatal accidents and injury to oneself and related to high distress more than double the risk for PTSD. Thirdly, we compared the relative merits of the DSM-IV’s three-factor solution for PTSD symptoms to alternative models. We found that the symptomatology is equally well accounted for using all factor analytic models as yet presented in the literature; the DSM-IV, we found, provides as good a fit to data as other models. Fourthly, we examined the neurofunctional correlates of PTSD symptoms and whether a treatment-induced (serotonin reuptake inhibitor - SSRI) reduction of PTSD symptoms is associated with altered rCBF during symptom provocation. Our results indicate that PTSD symptoms correlates with areas involved in memory, emotion, attention, and motor control and that SSRI treatment normalizes provocation-induced rCBF in these areas.

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6

Lee, Sherman. "The effect of acute cigarette smoke exposure on regional pulmonary blood flow, volume, red cell transit and polymorphonuclear leukocyte retention in the rabbit lung". Thesis, University of British Columbia, 1985. http://hdl.handle.net/2429/24840.

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Regional pulmonary blood flow and volume was measured in ten rabbits anesthetized with pentobarbital (30 mg/kg). Tracheostomy was performed and catheters were placed into the jugular vein and carotid artery. The cardiac ⁹⁹mtc output was measured using the indicator-dilution technique using Tc labelled RBC followed by an injection of radiolabelled macroaggregates (MAA) to mark regional blood flow. Measurements were made both before and after either exposure to cigarette smoke (3 cigarettes for ten minutes at 4 puffs/minute) or sham exposure to air. The animals were sacrificed and the lungs were removed with the vessels tied. The lungs were then inflated and rapidly frozen over liquid nitrogen. The lungs were sampled into slices by vertical height, each slice was further sampled and then gamma counted for the injected isotopes. Regional pulmonary blood flow was calculated by setting the total lung MAA counts for each MAA equal to the cardiac output so that the sample flow was calculated as the fraction of sample counts to total counts times the cardiac output. The blood volume was marked by the labelled RBC and RBC transit was calculated as blood volume (ml) divided by blood flow (ml/sec). In a second series of experiments (N=10) , ⁵¹Cr PMN were injected as a bolus along with ⁹⁹mtc RBC in an indicator-dilution run. Following the injection of the cells, the blood flow was marked with MAAs and then the same sham or smoke treatments were given as in the previous experiments. At the end of ten minutes, the animals were sacrificed and the lungs were processed the same as before. Regional PMN retention was calculated as the [formula omitted]. The data show that smoke exposure increased pulmonary blood volume (p<.01), pulmonary transit time (pMedicine, Faculty of
Pathology and Laboratory Medicine, Department of
Graduate

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7

Rothman, David J. "The Effect of Pre-Deployment Physiology as a Predictor of Post-Traumatic Stress Disorder Among a Sample of United States Army National Guard and Reserve Soldiers". VCU Scholars Compass, 2016. http://scholarscompass.vcu.edu/etd/4123.

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Potential risk factors for development of Post-Traumatic Stress Disorder (PTSD) are still unclear. One potential risk factor for the development of PTSD is an individual’s cardiovascular reactivity and recovery in response to stressor tasks. The current study was conducted with 763 Army National Guard and Army Reserve soldiers. Participants completed a stressful induction along with self-report measures prior to deployment. Post-deployment, self-report measures were completed to assess PTSD symptomatology and experiences related to deployment and combat. Multiple regression was used to determine the ability of blood pressure response to stress to predict PTSD symptoms immediately and one-year after return from deployment. Results indicated that soldiers who had a less reactive systolic blood pressure response to and recovery from stressor tasks reported more PTSD symptomatology immediately after and one year after return from deployment. These results suggest that soldiers who develop PTSD after deployment have less pre-deployment emotion regulation ability.

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8

Negrao, Bianca Lee. "Autonomic correlates at rest and during evoked attention in children with attention-deficit/hyperactivity disorder and effects of sympathomimetic medication". Diss., Pretoria : [s.n.], 2009. http://upetd.up.ac.za/thesis/available/etd-07072009-163036/.

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9

Lucey, James Vincent. "Regional cerebral blood flow (rCBF) assessed as uptake of '9'9'mTc-HMPAO in the basal ganglia and other brain regions in obsessive-compulsive disorder (OCD) on single photon tomography (SPET)". Thesis, Imperial College London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.392900.

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10

Marsh, Victoria Mary Chuck. "Sharing findings on sickle cell disorder in international collaborative biomedical research : an empirical ethics study in coastal Kenya". Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:b693b762-5ce8-4109-82ea-4cf7ba38675e.

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Against the background of a dilemma experienced by researchers during a genomics study at an established biomedical research centre in Kenya, the broad aims of this thesis are to develop appropriate responses to important ethical questions on sharing information on a common and serious genetic condition, sickle cell disorder, and assess the responsibilities of researchers in this regard. Using an empirical approach to normative reflection across two phases of qualitative research, I explore the nature of important moral concerns related to sharing sickle cell disease information from researchers’ and community members’ points of view; and develop a bottom-up normative analysis around the questions generated. This analysis interweaves community experiences, processes of community reasoning and ex situ normative reflection; placing community views and values centrally while referencing these to wider ethical debates, commentaries and guidelines in the literature. Two main outputs of this thesis are to provide recommendations for information sharing on SCD findings in the genomics study in Kilifi; and to propose a set of key issues to consider for this type of information in other studies and geographic settings. I conclude that researchers have a strong responsibility to share SCD information on affected children with families as a form of ancillary service (validating tests, counselling and care); but less responsibility to actively share carrier information. Concurrent responsibilities are working collaboratively with the Ministry of Health/District General Hospital to plan and implement services for SCD; ensuring counselling services support family stability as far as reasonably possible; and to build forms of community engagement and informed consent that counter risks of diagnostic interpretations of research.

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Mais fontes

Livros sobre o assunto "Blood disorder"

1

Myron, Susin, ed. Differential diagnosis of lymphoid disorder. New York: Igaku-Shoin, 1996.

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2

Blood disorders. St. Louis: Mosby, 1993.

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3

Matthias, Fritz Reinhard. Blood Coagulation Disorders. Berlin, Heidelberg: Springer Berlin Heidelberg, 1987. http://dx.doi.org/10.1007/978-3-642-83098-3.

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4

1916-, Ratnoff Oscar D., e Forbes C. D. 1938-, eds. Disorders of hemostasis. 2^a ed. Philadelphia: Saunders, 1991.

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5

Blood disorders: The facts. Oxford: Oxford University Press, 1985.

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6

d'Onofrio, Giuseppe, e Gina Zini, eds. Morphology of Blood Disorders. Oxford, UK: John Wiley & Sons, Ltd, 2014. http://dx.doi.org/10.1002/9781118442562.

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7

Jon, Aster, ed. Pathophysiology of blood disorders. New York: McGraw-Hill, 2011.

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8

Taloyan, Anett M. Coagulation: Kinetics, structure formation, and disorders. Hauppauge, N.Y: Nova Science Publisher's, 2011.

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9

1937-, Machleder Herbert I., ed. Vascular disorders of the upper extremity. 3^a ed. Armonk, N.Y: Futura Pub. Co., 1998.

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10

1937-, Machleder Herbert I., ed. Vascular disorders of the upper extremity. 2^a ed. Mount Kisco, N.Y: Futura Pub. Co., 1989.

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Capítulos de livros sobre o assunto "Blood disorder"

1

Brooks, John O., Po W. Wang e Terence A. Ketter. "Functional Brain Imaging Studies in Bipolar Disorder: Focus on Cerebral Metabolism and Blood Flow". In Bipolar Disorder, 200–209. Chichester, UK: John Wiley & Sons, Ltd, 2010. http://dx.doi.org/10.1002/9780470661277.ch15.

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2

Henriksen, L., H. Lou e P. Bruhn. "Focal Frontal Hypoperfusion in Children with Attentional Deficit Disorder". In Cerebral Blood Flow and Metabolism Measurement, 278–82. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-642-70054-5_44.

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Takayama, Masaomi, Keiichi Isaka, Yoshichika Suzuki, Hitoshi Funayama, Yasunobu Suzuki, Kiyoshi Akiya e Hans Bohn. "Placental Protein 19 in Clinical Blood Coagulation Disorder". In Perinatal Thrombosis and Hemostasis, 155–63. Tokyo: Springer Japan, 1991. http://dx.doi.org/10.1007/978-4-431-65871-9_16.

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Benton, L. A., S. J. Berry e F. E. Yates. "Ultradian Oscillations in Human Blood Pressure: Effects of Age". In Temporal Disorder in Human Oscillatory Systems, 141–49. Berlin, Heidelberg: Springer Berlin Heidelberg, 1987. http://dx.doi.org/10.1007/978-3-642-72637-8_16.

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Wilson, C. Brad, Leslie D. McLaughlin, Anand Nair, Philip J. Ebenezer, Rahul Dange e Joseph Francis. "Inflammation and Oxidative Stress in the Brain and Blood in an Animal Model of Post-Traumatic Stress Disorder: Mechanisms for PTSD Progression". In Comprehensive Guide to Post-Traumatic Stress Disorder, 1–13. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-08613-2_87-1.

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Sun, Jessica M., e Joanne Kurtzberg. "Umbilical Cord Blood or Mesenchymal Stromal Cells as Potential Therapies for Autism Spectrum Disorder". In Hematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases, 182–88. Boca Raton: CRC Press, 2021. http://dx.doi.org/10.1201/9781315151366-22.

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Peters, A. M., e D. M. Swirsky. "Blood disorders". In Clinical Nuclear Medicine, 525–39. Boston, MA: Springer US, 1998. http://dx.doi.org/10.1007/978-1-4899-3356-0_40.

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Zuo, Zhuang, Cheng Cameron Yin, Lixia Zhang, Lin Wang e Zhen Ren. "Blood Disorders". In Clinical Molecular Diagnostics, 641–64. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-1037-0_39.

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Faiman, Beth. "Blood and Blood Disorders". In Mental Health Practitioner's Guide to HIV/AIDS, 107–11. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4614-5283-6_14.

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Hallof-Büstrich, Heike, e Barbara Di Benedetto. "Examining the Coverage of Blood Vessels by Astrocyte Endfeet in an Animal Model of Major Depressive Disorder". In Methods in Molecular Biology, 255–63. New York, NY: Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9068-9_18.

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Trabalhos de conferências sobre o assunto "Blood disorder"

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Lv, Jiantao, Weiping Wang, Hong Wang, Deru Yu, Ning Zou, Chengyan Ma, Minghua Wang e Xuexi Tang. "Blood Fat Regulating Capsule Promotes Lipid Metabolism of Blood Fat in Mice with Fat Disorder". In 2007 1st International Conference on Bioinformatics and Biomedical Engineering. IEEE, 2007. http://dx.doi.org/10.1109/icbbe.2007.305.

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Jagdale, Amruta, e Rupali Sawant. "Neonatal Blood Analysis and Generating Disorder Estimation Using Image Processing". In 2017 International Conference on Computing, Communication, Control and Automation (ICCUBEA). IEEE, 2017. http://dx.doi.org/10.1109/iccubea.2017.8463913.

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Rabbani, Naila, e Paul John Thornalley. "Blood Biomarkers associated with Autism Spectrum Disorder may Provide Early Diagnosis". In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0151.

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Autism spectrum disorders (ASD) are a collection of neuropsychiatric disorders. ASD affects 1 in 87 in Qatar and is expected to increase. The high variability and heterogeneity of the symptoms makes diagnosis of ASD difficult and uncertain, particularly at the early stages of development. If detected early, clinical support can be given to promote optimal development and well-being of children with ASD and even achieve complete remission. The current method of diagnosing ASD is by observations and interviews made by experts in child development to assess child behavior, communication and cognition: the ADOS test. There is often delay in referral for expert diagnosis; delay is typically >18 months in Qatar and >4 years in EU and USA. The diagnostic accuracy is 60 – 70%. Mutations in proteins transporters of amino acids have been linked to some cases of ASD. We hypothesized that levels of amino acids in blood, including amino acids damaged by modification by sugars (glycation), oxidation and nitration may provide novel biomarker for diagnosis of ASD at very young age.

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Vivekanandan S, Trisha Chandra, Radha Mehta e Ganesh R. "Modeling of blood vessel for diabetic disorder and its cogent analysis". In 2014 International Conference on Advances in Electrical Engineering (ICAEE). IEEE, 2014. http://dx.doi.org/10.1109/icaee.2014.6838452.

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Tufa, Uilki, Dene Ringuette, Xue Fan Wang, Ofer Levi e Peter Carlen. "Two-photon microscopy imaging of blood brain barrier leakage in fetal alcohol disorder mice". In Bio-Optics: Design and Application. Washington, D.C.: OSA, 2017. http://dx.doi.org/10.1364/boda.2017.jtu4a.9.

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Rechkalov, A. V., O. L. Rechkalova e N. R. Halliulina. "Efficacy of Neurodynamic Method Complex Rehabilitation of Patients with Acute Cerebral Blood Circulation Disorder". In Proceedings of the International Conference on Health and Well-Being in Modern Society (ICHW 2019). Paris, France: Atlantis Press, 2019. http://dx.doi.org/10.2991/ichw-19.2019.48.

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Dow, William, Frank Jacobitz e Peter Chen. "On the Microcirculation in the Human Conjunctiva". In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14104.

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The microcirculation includes the smallest arterioles, capillaries, and venules with vessel diameters ranging from 8 to 150 μm and it represents a region where active and passive exchanges of nutrients and gasses take place. The microvessels’ rheological properties differ from large arteries: they are less viscous, and demonstrate autoregulation [3]. Epidemiologists study the microcirculation in detail and have identified associations between microvascular disorder and organ damage. The organization of the microvascular network can be different in different sites but the networks serve the common function in the delivery of nutrients to the surrounding tissues. This is controlled by a distribution of blood flow based on local metabolic needs. Under challenge or in the development of diseases, the microcirculation responds by selectively regulating blood flow. A comparison between healthy and diseased states may lead to the identification of changes in the microcirculation that can be used as diagnosis for a variety of vascular related disorders [4, 5].

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Katagiri, Kengo, Absei Krdey, Sota Yamamoto e Marie Oshima. "Strong Coupled Fluid-Structure Interaction Simulation of Cerebrovascular System Using Multi-Scale Model". In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80415.

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Cerebrovascular disorder such as subarachnoid hemorrhage is the number 3 cause of death in Japan [1]. Initiation and growth of those diseases depend on hemodynamic factors such as Wall Shear Stress (WSS) or blood pressure induced by blood flow [2]. Therefore the information on the magnitude and the distribution of WSS is important to predict the consequences.

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Aeinfar, Vahid, Hoorieh Mazdarani, Fatemeh Deregeh, Mohsen Hayati e Mehrdad Payandeh. "Multilayer Perceptron Neural Network with supervised training method for diagnosis and predicting blood disorder and cancer". In 2009 IEEE International Symposium on Industrial Electronics (ISIE 2009). IEEE, 2009. http://dx.doi.org/10.1109/isie.2009.5213591.

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Jan, Zala, Christian Gostečnik e Veronika Kralj-Iglič. "Adverse Human Health Outcomes Associated with Psychologi-cal Trauma: A review". In Socratic Lectures 7. University of Lubljana Press, 2022. http://dx.doi.org/10.55295/psl.2022.d7.

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Until 30 years ago it was believed that psychological stress increases cortisol secretion, but later stud-ies gave contradictory results. Decrease in cortisol levels in post-traumatic stress disorder (PTSD) reflects a nonnormative and inadequate response to severe stressors, with its pathophysiology in-volving maladaptation or dysfunction in stress-regulatory systems. To have more insights in re-sponse of human body to physiological stress, inflammatory signals, oxidative stress parameters and other health parameters were measured. As for the cortisol level results, also inflammatory signals, including proinflammatory and anti-inflammatory cytokines and C-reactive protein (CRP), have been reported to increase and decrease in PTSD. Levels of interleukin (IL)-1β, IL-2, IL-4, IL-6, IL-8, IL-10, tumour necrosis factor (TNF)-α, interferon gamma (IFN-γ) and CRP were reported higher and lower in blood samples of individuals with PTSD. Some studies report that dysregulation of the stress axis could have direct effects on brain regions responsible for the regulation of fear and anxiety (such as the prefrontal cortex, insula, amygdala, and hippocampus). Early-life stress, such as child-hood adversity (abuse, neglect, or family disfunction), is a potent risk factor for developing PTSD in response to later trauma, and elevated peripheral markers of inflammation are one of the best-repli-cated findings in children and adults with early-life stress. Those who develop PTSD may have an inability or failure to activate an innate immune response. PTSD can also result in other adverse outcomes, such as heightened oxidative stress (OXS), eating disorders, metabolic disorder, and car-diovascular disease (CVD). Since the results are very contradictory for PTSD and inflammation re-sponse of the human body, further research is important. Small cellular particles that can be isolated from body fluids present potential biomarkers of the clinical status and will be considered in plan-ning the future research. This contribution presents perspectives in assessment of psychological stress by objective parameters. Keywords: Cortisol; Post-traumatic stress disorder; Inflammatory response; Oxidative stress; Cyto-kines; Eating disorders; Metabolic disorder; Cardiovascular disease; Small cellular particles as stress markers, Extracellular vesicles as stress markers

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Relatórios de organizações sobre o assunto "Blood disorder"

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Yang, Ruoting, Jr Daigle, Muhie Bernie J., Hammamieh Seid Y., Jett Rasha, Petzold Marti, Doyle Linda e Francis J. III. Core Modular Blood and Brain Biomarkers in Social Defeat Mouse Model for Post Traumatic Stress Disorder. Fort Belvoir, VA: Defense Technical Information Center, agosto de 2013. http://dx.doi.org/10.21236/ada596945.

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yu, luyou, jinping yang, xi meng e yanhua ling. Efficacy and safety of acupuncture combined with probiotics in the treatment of type 2 diabetes mellitus with intestinal microbiota disorder: A protocol for systematic review and meta analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, setembro de 2022. http://dx.doi.org/10.37766/inplasy2022.9.0001.

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Review question / Objective: Efficacy and safety of acupuncture combined with probiotics in the treatment of type 2 diabetes mellitus with intestinal microbiota disorder: A protocol for systematic review and meta analysis. Eligibility criteria: 1.The literatures of type 2 diabetes patients were included without restriction on gender, age, race, disease course and blood glucose control of the subjects. 2. The relevant literatures included in human intestinal flora do not strictly restrict the test methods and key indicators of fecal specimens. 3. Relevant literatures with no statistically significant difference in general data between the experimental group and the control group were included. 4.There is no restriction on whether blind method or distributive hiding method is used to include Chinese and English literatures whose research type is correlation study. 5. References that clearly indicated standard deviation (SD), mean value or which could be calculated by formula were included.

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Wu, Xiaoqi, Maoxia Fan, Yaobo Pan e Dona Guo. Quality of Evidence Supporting the Effects of Ginkgo Terpene Lactone Preparations in Ischemic Stroke: An Overview of Systematic Reviews and Meta-Analyses. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, setembro de 2022. http://dx.doi.org/10.37766/inplasy2022.9.0124.

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Review question / Objective: 2.2.1 Type of studies SRs/MAs of Randomized Controlled Trials (RCTs) of GTLP for IS in any language. 2.2.2 Type of Participants Included patients were diagnosed with IS according to international or national standards, regardless of race, age, gender, time of onset, and source of cases. 2.2.3 Type of Intervention The intervention method in the control group was routine treatment, and the intervention method in the intervention group was GTLP treatment or GTLP combined with the treatment of the control group. 2.2.4 Types of outcomes Conclusions at least need to include clinical efficacy analysis and National Institute of Health Stroke Scale (NIHSS). Condition being studied: Stroke is the second leading cause of death and third leading cause of disability globally.Among them, ischemic stroke (IS) accounts for 70% of all stroke types. It is a central nervous system disease caused by cerebral blood circulation disorder, ischemia and hypoxia .The incidence rate is high and increasing year by year, the age of onset is younger, the disability rate is high, and most patients have different degrees of limb motor dysfunction.In order to reduce the burden of stroke on the society and the patient's family, many articles proposed to strengthen the primary stroke prevention - behavior change and drug intervention.

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Neykova, Konstantsa, Violeta Dimitrova e Rumen Dimitrov. Antithrombotic Medication Outcome on Uteroplacental Blood Flow in Patients with Previous Obstetric History of Placental Mediated Disorders. "Prof. Marin Drinov" Publishing House of Bulgarian Academy of Sciences, março de 2021. http://dx.doi.org/10.7546/crabs.2021.03.16.

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Zhuo, Guifeng, Hengwang Yu, Ran Liao, Xuexia Zheng, Dongmin Liu, Libing Mei e Guiling Wu. Auricular point pressing therapy for obstructive sleep apnea hypoventilation syndrome: A protocol for systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, maio de 2022. http://dx.doi.org/10.37766/inplasy2022.5.0015.

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Review question / Objective: Patients with obstructive sleep apnea hypoventilation syndrome (OSAHS) suffer from repeated hypoxemia, hypercapnia, and sleep structure disorders at night, leading to daytime lethargy and complications of heart, brain, lung, and blood vessel damage, which seriously affect their quality of life and life span. Clinical studies have shown that auricular point pressing therapy has an excellent therapeutic effect on OSAHS, and has the potential to be a complementary and alternative therapy for patients with OSAHS. Currently, systematic reviews and meta-analyses evaluating the efficacy and safety of electroacupuncture for the treatment of OSAHS are lacking. This study aimed to address this deficiency. Information sources: RCTs of auricular point pressing therapy in the treatment of OSAHS were searched in the Web of Science, PubMed, Cochrane Library, Embase, Allied and Complementary Medicine Database (AMED), China Science and Technology Journal Database (VIP), China National Knowledge Infrastructure (CNKI), and Wan-Fang Database. The retrieval time is from database construction to the present.

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Cord blood metabolites linked with an ADHD diagnosis in childhood. ACAMH, março de 2021. http://dx.doi.org/10.13056/acamh.15036.

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Researchers in the USA have analysed whether the levels of branched-chain amino acids (BCAAs) detectable in maternal plasma and newborn cord blood are associated with the development of attention-deficit hyperactivity disorder (ADHD) later in childhood.

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