Literatura científica selecionada sobre o tema "B 358 t732 1993"

A Dictyostelium membrane fraction rich in vacuolar proton pumps, previously described by Nolta et al. (J. Biol. Chem. 266, 18,318-18,323, 1991), was used as the immunogen for production of monoclonal antibodies. We obtained antibodies that recognized polypeptides of 100 kDa and 68 kDa, corresponding to the two largest subunits of the vacuolar proton pump. In indirect immunofluorescence experiments, these two subunits were located on an interconnected collection of tubules and vacuoles. On frozen thin sections they were found principally on membranes of vacuoles and collections of small vesicles typically located just internal to the plasma membrane. These vesicles and vacuoles had electron-translucent lumens. No other structures in axenically grown Dictyostelium cells were labeled to a significant extent by these two antibodies. Using an affinity-purified antibody to calmodulin and a monospecific antibody to the B subunit of the chromaffin granule vacuolar ATPase, markers known to label the membranes of the contractile vacuole complex in Dictyostelium (Zhu and Clarke, J. Cell Biol. 118, 347–358, 1992; Heuser et al., J. Cell Biol. 121, 1311–1327, 1993), we showed that the 100 kDa and 68 kDa subunits had the same distribution as these two markers. Co-localization was seen in both interphase and mitotic cells. Thus, our results support the conclusion that vacuolar proton pumps are located principally on the membranes of the contractile vacuole complex in Dictyostelium. In addition, in indirect immunofluorescence experiments, these monoclonal antibodies provided improved images of the organization of the contractile vacuole system.

-Dennis Walder, Robert D. Hamner, Derek Walcott. New York: Twayne Publishers, 1993. xvi + 199 pp.''Critical perspectives on Derek Walcott. Washington DC: Three continents, 1993. xvii + 482 pp.-Yannick Tarrieu, Lilyan Kesteloot, Black writers in French: A literary history of Negritude. Translated by Ellen Conroy Kennedy. Washington DC: Howard University Press, 1991. xxxiii + 411 pp.-Renée Larrier, Carole Boyce Davies ,Out of the Kumbla: Caribbean women and literature. Trenton NJ: Africa World Press, 1990. xxiii + 399 pp., Elaine Savory Fido (eds)-Renée Larrier, Evelyn O'Callaghan, Woman version: Theoretical approaches to West Indian fiction by women. London: Macmillan Caribbean, 1993. viii + 126 pp.-Lisa Douglass, Carolyn Cooper, Noises in the blood: Orality, gender and the 'vulgar' body of Jamaican popular culture. London: Macmillan Caribbean, 1993. ix + 214 pp.-Christine G.T. Ho, Kumar Mahabir, East Indian women of Trinidad & Tobago: An annotated bibliography with photographs and ephemera. San Juan, Trinidad: Chakra, 1992. vii + 346 pp.-Eva Abraham, Richenel Ansano ,Mundu Yama Sinta Mira: Womanhood in Curacao. Eithel Martis (eds.). Curacao: Fundashon Publikashon, 1992. xii + 240 pp., Joceline Clemencia, Jeanette Cook (eds)-Louis Allaire, Corrine L. Hofman, In search of the native population of pre-Colombian Saba (400-1450 A.D.): Pottery styles and their interpretations. Part one. Amsterdam: Natuurwetenschappelijke Studiekring voor het Caraïbisch Gebied, 1993. xiv + 269 pp.-Frank L. Mills, Bonham C. Richardson, The Caribbean in the wider world, 1492-1992: A regional geography. Cambridge: Cambridge University Press, 1992. xvi + 235 pp.-Frank L. Mills, Thomas D. Boswell ,The Caribbean Islands: Endless geographical diversity. New Brunswick NJ: Rutgers University Press, 1992. viii + 240 pp., Dennis Conway (eds)-Alex van Stipriaan, H.W. van den Doel ,Nederland en de Nieuwe Wereld. Utrecht: Aula, 1992. 348 pp., P.C. Emmer, H.PH. Vogel (eds)-Idsa E. Alegría Ortega, Francine Jácome, Diversidad cultural y tensión regional: América Latina y el Caribe. Caracas: Nueva Sociedad, 1993. 143 pp.-Barbara L. Solow, Ira Berlin ,Cultivation and culture: Labor and the shaping of slave life in the Americas. Charlottesville: University Press of Virginia, 1993. viii + 388 pp., Philip D. Morgan (eds)-Andrew J. O'Shaughnessy, Karen Ordahl Kupperman, Providence Island, 1630-1641: The other puritan colony. Cambridge: Cambridge University Press, 1993. xiii + 393 pp.-Armando Lampe, Johannes Meier, Die Anfänge der Kirche auf den Karibischen Inseln: Die Geschichte der Bistümer Santo Domingo, Concepción de la Vega, San Juan de Puerto Rico und Santiago de Cuba von ihrer Entstehung (1511/22) bis zur Mitte des 17. Jahrhunderts. Immensee: Neue Zeitschrift für Missionswissenschaft, 1991. xxxiii + 313 pp.-Edward L. Cox, Carl C. Campbell, Cedulants and capitulants; The politics of the coloured opposition in the slave society of Trinidad, 1783-1838. Port of Spain, Trinidad: Paria Publishing, 1992. xv + 429 pp.-Thomas J. Spinner, Jr., Basdeo Mangru, Indenture and abolition: Sacrifice and survival on the Guyanese sugar plantations. Toronto: TSAR, 1993. xiii + 146 pp.-Rosemarijn Hoefte, Lila Gobardhan-Rambocus ,Immigratie en ontwikkeling: Emancipatie van contractanten. Paramaribo: Anton de Kom Universiteit, 1993. 262 pp., Maurits S. Hassankhan (eds)-Juan A. Giusti-Cordero, Teresita Martínez-Vergne, Capitalism in colonial Puerto Rico: Central San Vicente in the late nineteenth century. Gainesville: University Press of Florida, 1992. 189 pp.-Jean Pierre Sainton, Henriette Levillain, La Guadeloupe 1875 -1914: Les soubresauts d'une société pluriethnique ou les ambiguïtés de l'assimilation. Paris: Autrement, 1994. 241 pp.-Michèle Baj Strobel, Solange Contour, Fort de France au début du siècle. Paris: L'Harmattan, 1994. 224 pp.-Betty Wood, Robert J. Stewart, Religion and society in post-emancipation Jamaica. Knoxville: University of Tennessee Press, 1992. xx + 254 pp.-O. Nigel Bolland, Michael Havinden ,Colonialism and development: Britain and its tropical colonies, 1850-1960. New York: Routledge, 1993. xv + 420 pp., David Meredith (eds)-Luis Martínez-Fernández, Luis Navarro García, La independencia de Cuba. Madrid: MAPFRE, 1992. 413 pp.-Pedro A. Pequeño, Guillermo J. Grenier ,Miami now! : Immigration, ethnicity, and social change. Gainesville: University Press of Florida, 1992. 219 pp., Alex Stepick III (eds)-George Irving, Alistair Hennessy ,The fractured blockade: West European-Cuban relations during the revolution. London: Macmillan Caribbean, 1993. xv + 358 pp., George Lambie (eds)-George Irving, Donna Rich Kaplowitz, Cuba's ties to a changing world. Boulder CO: Lynne Rienner, 1993, xii + 263 pp.-G.B. Hagelberg, Scott B. MacDonald ,The politics of the Caribbean basin sugar trade. New York: Praeger, 1991. vii + 164 pp., Georges A. Fauriol (eds)-Bonham C. Richardson, Trevor W. Purcell, Banana Fallout: Class, color, and culture among West Indians in Costa Rica. Los Angeles: UCLA Center for Afro-American studies, 1993. xxi + 198 pp.-Gertrude Fraser, George Gmelch, Double Passage: The lives of Caribbean migrants abroad and back home. Ann Arbor: University of Michigan Press, 1992. viii + 335 pp.-Gertrude Fraser, John Western, A passage to England: Barbadian Londoners speak of home. Minneapolis: University of Minnesota Press, 1992. xxii + 309 pp.-Trevor W. Purcell, Harry G. Lefever, Turtle Bogue: Afro-Caribbean life and culture in a Costa Rican Village. Cranbury NJ: Susquehanna University Press, 1992. 249 pp.-Elizabeth Fortenberry, Virginia Heyer Young, Becoming West Indian: Culture, self, and nation in St. Vincent. Washington DC: Smithsonian Institution Press, 1993. x + 229 pp.-Horace Campbell, Dudley J. Thompson ,From Kingston to Kenya: The making of a Pan-Africanist lawyer. Dover MA: The Majority Press, 1993. xii + 144 pp., Margaret Cezair Thompson (eds)-Kumar Mahabir, Samaroo Siewah, The lotus and the dagger: The Capildeo speeches (1957-1994). Port of Spain: Chakra Publishing House, 1994. 811 pp.-Donald R. Hill, Forty years of steel: An annotated discography of steel band and Pan recordings, 1951-1991. Jeffrey Thomas (comp.). Westport CT: Greenwood, 1992. xxxii + 307 pp.-Jill A. Leonard, André Lucrèce, Société et modernité: Essai d'interprétation de la société martiniquaise. Case Pilote, Martinique: Editions de l'Autre Mer, 1994. 188 pp.-Dirk H. van der Elst, Ben Scholtens ,Gaama Duumi, Buta Gaama: Overlijden en opvolging van Aboikoni, grootopperhoofd van de Saramaka bosnegers. Stanley Dieko. Paramaribo: Afdeling Cultuurstudies/Minov; Amsterdam: Koninklijk Instituut voor de Tropen, 1992. 204 pp., Gloria Wekker, Lady van Putten (eds)-Rosemarijn Hoefte, Chandra van Binnendijk ,Sranan: Cultuur in Suriname. Amsterdam: Koninklijk Instituut voor de Tropen/Rotterdam: Museum voor Volkenkunde, 1992. 159 pp., Paul Faber (eds)-Harold Munneke, A.J.A. Quintus Bosz, Grepen uit de Surinaamse rechtshistorie. Paramaribo: Vaco, 1993. 176 pp.-Harold Munneke, Irvin Kanhai ,Strijd om grond in Suriname: Verkenning van het probleem van de grondenrechten van Indianen en Bosnegers. Paramaribo, 1993, 200 pp., Joyce Nelson (eds)-Ronald Donk, J. Hartog, De geschiedenis van twee landen: De Nederlandse Antillen en Aruba. Zaltbommel: Europese Bibliotheek, 1993. 183 pp.-Aart G. Broek, J.J. Oversteegen, In het schuim van grauwe wolken: Het leven van Cola Debrot tot 1948. Amsterdam: Muelenhoff, 1994. 556 pp.''Gemunt op wederkeer: Het leven van Cola Debrot vanaf 1948. Amsterdam: Muelenhoff, 1994. 397 pp.

Abstract We recently identified a human minor histocompatibility (H) antigen encoded by the UDP glycosyltransferase 2 family, polypeptide B17 (UGT2B17) gene. UGT2B17 is a metabolic enzyme that is highly expressed in liver and colon, and at low levels in hematopoietic cells. UGT2B17 conjugates exogenous and endogenous compounds including steroid hormones and facilitates their elimination. The immunogenicity of the UGT2B17 was due to differential expression of the protein in donor and recipient cells as a consequence of a homozygous deletion of the UGT2B17 gene in the recipient. Deletion of this gene in a subset of normal individuals suggested two mechanisms by which UGT2B17 could affect the outcome of allogeneic BMT. First, the expression of UGT2B17 in recipient but not donor cells could provide minor H antigens and increase GVHD. Second, the presence of UGT2B17 in the donor or recipient could affect the metabolism, function, or toxicity related to endogenous hormones or drugs administered with BMT. The purposes of this study were to determine the frequency of homozygous UGT2B17 deletion in healthy individuals and patients with hematological disease and whether a deficiency of UGT2B17 in donor and/or recipient affected the outcome of allogeneic BMT. A total of 435 recipients were selected from the patients who received unrelated BMT through the Japanese Marrow Donor Program between January 1993 and March 2000. Selection criteria were (1) matched at HLA-A, B, C and DRB1 genotypes, (2) unmanipulated marrow graft, (3) cyclosporine A or tacrolimus as GVHD prophylaxis, and (4) available DNA was stored. DNA from a total of 358 of the donors was also available. Homozygous deletion of the UGT2B17 gene determined by SSP-PCR was found in 320 (84.8%) of 377 donors and 358 (82.3%) of 435 patients (P=0.32, χ2 test). These frequencies of UGT2B17 deletion were substantially higher than the 11% observed in the Caucasian population in a previous study. A multivariate analysis (Cox proportional hazard model) showed no significant association between UGT2B17-mismatch in the GVHD direction and the incidence of acute GVHD (grade II-IV or III-IV), chronic GVHD, relapse, or survival. However, a deletion of UGT2B17 in the donor was a favorable factor for transplant-related mortality (TRM) (relative risk, 0.530; 95% CI, 0.334 to 0.841; P=0.007), survival (0.567; 0.387 to 0.831; P=0.036) and disease-free survival (DFS) (0.647; 0.443 to 0.945; P=0.024). We also analyzed these outcomes in the subset of patients with standard-risk malignant disease by the Kaplan-Meier method. TRM, survival, and DFS at eight years after transplantation were 23.7% for patients transplanted from a UGT2B17-deleted donor vs 52.9% for patients with a UGT2B17-positive donor (P=0.001); 68.3% vs 37.5% (P=0.0009); and 66.9% vs 37.5% (P=0.0009), respectively. These data suggest that the UGT2B17 enzyme in donor-derived blood cells may affect the metabolism of exogenously administered or endogenous molecules and adversely influence the outcome of unrelated BMT. Analysis in another patient population will be important to confirm our results.

Эндофуллерены, содержащие один или несколько атомов металла внутри углеродного каркаса (металлофуллерены), представляют большой практический интерес в связи с возможностью создания на их основе эффективных контрастирующих агентов для магнитно-резонансной томографии (МРТ), антиоксидантных и противораковых средств. Данные соединения могут быть также использованы в спинтронике для создания наноразмерных электронных устройств. В настоящей работе в рамках теории функционала плотности произведен расчет структурных, электронных и термодинамических характеристик эндофуллеренов металлов подгруппы скандия с числом инкапсулированных атомов от одного до семи в газовой фазе. Описаны стабильные структуры с симметриямиCs, C2, C3 и Ci, соответствующие позициям, занимаемым атомами металла внутри каркаса фуллерена. Установлен теоретический предел числа атомов металла, при котором структура эндофуллерена сохраняет устойчивость – шесть атомов для скандия, четыре для иттрия и три для лантана. Расчет показывает, что наиболее устойчивыми являются структуры с двумя и тремя инкапсулированными атомами. Описана зависимость между числом инкапсулированных атомов металла и характером распределения электронной плотности. Общий заряд на инкапсулированном металлическом кластере положителен для соединений Me@C60 – Me3@C60, слабо положителен для Me4@C60(отдельные атомы имеют отрицательный заряд) и отрицателен для соединений Me5C60 – Me6@C60. Описан эффект спиновой утечки для структур с основным дублетным спиновым состоянием. Для соединений с тремя и более инкапсулированными атомами данный эффект незначителен, что указывает на нецелесообразность создания контрастирующих агентов для МРТ на их основе. ЛИТЕРАТУРА 1. Kroto H. W., Heath J. R., O’Brien S. C., Curl R. F., Smalley R. E. C60: Buckminsterfullerene. Nature.1985;318(6042): 162–163. DOI: https://doi.org/10.1038/318162a02. Kratschmer W., Lamb L. D., Fostiropoulos K., Huffman D. R. Solid C60: a new form of carbon. 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Adger, W.N., Kelly, P.M., Winkels, A., Huy, L.Q. and Locke, C. (2002). Migration, remittances, livelihood trajectories, and social resilience. AMBIO: A Journal of the Human Environment, Vol. 31 No. 4, p. 358-366. Alagie Bah. (2018). Farmers Awareness and Adaptation to Climate Change in Kaffrine Region of Senegal. German Federal Ministry of Education and Research (BMBF) and the West African Science Service Centre in Climate Change and Adapted Land Use Bhatta, G.D., Aggarwal, P.K., Kristjanson, P. and Shrivastava, A.K. (2016). Climatic and non climatic factors influencing changing agricultural practices across different rainfallregimes in South Asia”, Current Science Vol. 110 No. 7, p. 1272. Census of the Gambia (2014). Government of the Gambia, Banjul Chandan Kumar, Jha, Vijaya Gupta, Utpal Chattopadhyay, Binilkumar and Amarayil Sreeraman. (2017). Migration as adaptation strategy to cope with climate change: A study of farmers’ migration in rural India. International Journal of Climate ChangeStrategies and Management. Volume 10:1 Cho Renee. (2021). Climate Migration: An Impending Global Challenge. Columbia ClimateSchool. Climate, Earth and Society. Climate of Foni Bondali District (2022). Ministry of Water Resources, Banjul, Gambia. Conway, D. and Cohen, J.H. (1998). Consequences of migration and remittances for Mexicantransnational communities. Economic Geography, Vol. 74 No. 1, pp. 26-44. Bradatan, C. and Hayhoe, K. (2013). Migration and Climate change in Senegal. Texas Tech University De Haan, A., Brock, K. and Coulibaly, N. (2002). Migration, livelihoods and institutions:contrasting patterns of migration in Mali. Journal of Development Studies. Vol. 38 No. 5, pp. 37-58. De Haas, H. (2010), Migration and development: a theoretical perspective1. The InternationalMigration Review. Vol. 44 No. 1, pp. 227-264. Jha, C.K., Gupta, V., Chattopadhyay, U. and Amarayil Sreeraman, B. (2018). Migration as adaptation strategy to cope with climate change: A study of farmers’ migration in rural India. International Journal of Climate Change Strategies and Management. Vol. 10 No.1, pp. 121-141. Massey, D.S., Arango, J., Hugo, G., Kouaouci, A., Pellegrino, A. and Taylor, J.E. (1993).Theories of international migration: a review and appraisal. Population and Development. Review. Vol. 19 No. 3, pp. 431-466. Oli Brown. (2007). Fighting Climate Change: Human solidarity in a divided world. Human Development Report 2007/2008. https://www.iisd.org/system/files/publications/climate-forced-migration.pdf Science for Environment Policy. (2015). Migration in response to environmental change. European Commission. Thematic Issue 51. Taylor, E.J. (1999). The new economics of labour migration and the role of remittances in the migration Process. International Migration (Geneva, Switzerland). Vol. 37 No. 1, pp. 63-88. Woodruff, C. and Zenteno, R. (2007). Migration networks and microenterprises in Mexico. Journal of Development Economics. Vol. 82 No. 2, pp. 509-528.

Ammonia is an indispensable component of modern fertilizers and a key nitrogen source in chemical synthesis, making it one of the highest-volume commodity chemicals.1–3 However, its synthesis via the Haber-Bosch process contributes significantly to global carbon emissions, motivating the development of alternative pathways for ammonia synthesis.4–6 Of many alternative methods, an electrochemical lithium-mediated process is one of the most promising. Since its initial implementations,7–9 novel cell designs10–12 and electrolytes13–15 have greatly improved the selectivity and productivity of lithium-mediated electrochemical ammonia synthesis (LiMEAS), but questions persist regarding the mechanism of nitrogen fixation and the role of lithium in this process (Figure 1a). In particular, many in the literature have alluded to the possible importance of lithium passivation species, commonly known as the solid electrolyte interphase (SEI), but their small length-scale and reactivity make direct observation challenging.11,13,15 In this work, we leveraged a multiscale approach to reveal connections between device-scale performance and nanoscale passivation behavior in LiMEAS. We used four model systems, varying the presence of proton donor (no proton donor or 0.1 M ethanol), and the feed gas (Ar or N2), which allowed us to examine the influence of the two reactive components in LiMEAS which are not usually present for lithium metal electrodeposition in the literature: proton donor and nitrogen. For each model system, we quantified major reaction products (Figure 1b, f). Ammonia and lithium nitride were measured by the salicylate colorimetric assay,16 hydrogen by online gas chromatography (GC), and residual lithium by galvanostatic stripping. We used scanning electron microscopy to observe microscale morphology, and to gain deeper insights into nanoscale surface morphology, we implemented cryo-electron microscopy (cryo-EM) (Figure 1c-d, g-h). Cryo-EM is a powerful technique that enables high-resolution observation of beam-sensitive metallic lithium and SEI materials by holding them at cryogenic temperatures, which preserve their native state.17 In addition to nanoscale morphological information, cryo-EM provided chemical information in the form of selected-area electron diffraction (SAED), energy-dispersive X-ray spectroscopy (EDS), and electron energy loss spectroscopy (EELS), which were paired with X-ray photoelectron spectroscopy (XPS) to develop an understanding of the chemistry of the interphase. Our results indicate that the proton donor governs reactivity toward nitrogen reduction in LiMEAS via its influence on the SEI. In the absence of proton donor, the lithium deposit forms a passivating, mosaic-structured SEI that preserves the deposited lithium, regardless of whether the feed gas is argon or nitrogen (Figure 1e). With the addition of ethanol, the surface changes significantly. The resultant SEI does not passivate the lithium, allowing it to react with nitrogen and other electrolyte components (Figure 1i). This permeable SEI appears to be mosaic in structure, with organic phases dominated by ethanol breakdown products, and its formation is key to the functionality of lithium-mediated ammonia synthesis. These findings can help guide the development of optimal SEIs for selectivity and stability of LiMEAS, and beyond that, offer insights into the characteristics of the lithium SEI at a reactive rather than passivated interface. Figure 1. (a) Schematic of possible lithium reactions. 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This paper aims at analyzing the use of scientific electronic papers and journals in the didactics material of the specialization Course on Educational Technologies from UFSCar. The bibliographical analysis focused on the development and legitimacy of scientific journals. The purpose of the documental analysis on the didactic material, composed by 48 volumes, was to verify the kinds of material cited and suggested in the multimedia study guides. The data show that books are the most cited material, whereas other electronic materials are the most suggested kind of complementary material. The international scientific community considers papers published in scientific journals as the main and most legitimate mean of scientific knowledge sharing. They are the third most cited and suggested kind of material by the author-docents. This result indicates dissociation between the course didactics material and its innovative proposal of hybrid, flexible and integrated education. It is also dissociated from the international trends of scientific knowledge legitimacy. Such dissociation, commonly found in human sciences, may jeopardize the quality of the Brazilian science and its integration in the international scientific community.ResumoEste artigo pretende analisar a utilização de artigos e periódicos científicos eletrônicos no material didático do curso de especialização em Educação e Tecnologias da UFSCar. Para tanto, foi feita análise bibliográfica sobre o desenvolvimento dos periódicos científicos e a questão da legitimidade conferida a esse tipo de publicação. A análise documental do material didático do curso, composto por 48 volumes, teve como objetivo avaliar o tipo de material citado e indicado nos guias de estudo multimídia. Os dados levantados mostram que os livros são o material mais citado pelos autores do material didático, enquanto outros tipos de material eletrônico compõem a maioria das indicações de material complementar. Os artigos publicados em periódicos científicos, considerados pela comunidade científica internacional o principal e mais legítimo meio de divulgação de ciência, aparecem como terceiro tipo de material mais citado e indicado pelos docentes autores. Esse resultado aponta uma dissociação do material didático do curso e a sua proposta inovadora de formação híbrida, flexível e integrada, bem como as tendências internacionais de legitimação do conhecimento científico. Tal dissociação, comumente encontrada nas ciências humanas, pode ferir a qualidade da ciência produzida no Brasil e sua integração na comunidade científica internacional.Palavras-chave: Periódicos científicos, Legitimidade, Material didático, Educação a distância.Keywords: Scientific journals, Legitimacy, Didactics materials, Educational technology.ReferencesBATES, Tony. The promise and the myths of e-learning in post-secondary education. In: CASTELLS, Manuel. The network society: a cross-cultural perspective. 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