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Not Available, Not Available. "International course on Laboratory Animal Science - Utrecht, The Netherlands". European Journal of Applied Physiology 84, n.º 1-2 (16 de fevereiro de 2001): 168. http://dx.doi.org/10.1007/s004210000350.
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Not Available, Not Available. "International course on Laboratory Animal Science - Utrecht, The Netherlands". European Journal of Applied Physiology 81, n.º 3 (1 de janeiro de 2000): 258. http://dx.doi.org/10.1007/s004210050040.
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Andel, Joan D., H. E. Coomans, Rene Berg, James N. Sneddon, Thomas Crump, H. Beukers, M. Heins et al. "Book Reviews". Bijdragen tot de taal-, land- en volkenkunde / Journal of the Humanities and Social Sciences of Southeast Asia 147, n.º 4 (1991): 516–46. http://dx.doi.org/10.1163/22134379-90003185.
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- Joan D. van Andel, H.E. Coomans, Building up the the future from the past; Studies on the architecture and historic monuments in the Dutch Caribbean, Zutphen: De Walburg Pers, 1990, 268 pp., M.A. Newton, M. Coomans-Eustatia (eds.) - Rene van den Berg, James N. Sneddon, Studies in Sulawesi linguistics, Part I, 1989. NUSA, Linguistic studies of Indonesian and other languages in Indonesia, volume 31. Jakarta: Badan Penyelenggara Seri Nusa, Universitas Katolik Indonesia Atma Jaya. - Thomas Crump, H. Beukers, Red-hair medicine: Dutch-Japanese medical relations. Amsterdam/Atlanta, GA: Rodopi, Publications for the Netherlands Association of Japanese studies No. 5, 1991., A.M. Luyendijk-Elshout, M.E. van Opstall (eds.) - M. Heins, Kees P. Epskamp, Theatre in search of social change; The relative significance of different theatrical approaches. Den Haag: CESO Paperback no. 7, 1989. - Rudy De Iongh, Rainer Carle, Opera Batak; Das Wandertheater der Toba-Batak in Nord Sumatra. Schauspiele zur Währung kultureller Identität im nationalen Indonesischen Kontext. Veröffentlichungen des Seminars fur Indonesische und Südseesprachen der Universität Hamburg, Band 15/1 & 15/2 (2 Volumes), Berlin: Dietrich Reimer Verlag, 1990. - P.E. de Josselin de Jong, Birgit Rottger-Rossler, Rang und Ansehen bei den Makassar von Gowa (Süd-Sulawesi, Indonesien), Kölner Ethnologische Studien, Band 15. Dietrich Reimar Verlag, Berlin, 1989. 332 pp. text, notes, glossary, literature. - John Kleinen, Vo Nhan Tri, Vietnam’s economic policy since 1975. Singapore: ASEAN Economic research unit, Institute of Southeast Asian studies, 1990. xii + 295 pp. - H.M.J. Maier, David Banks, From class to culture; Social conscience in Malay novels since independence, Yale, 1987. - Th. C. van der Meij, Robyn Maxwell, Textiles of Southeast Asia; Tradition, trade and transformation. Melbourne/Oxford/Auckland/New York: Australian National Gallery/Oxford University Press. - A.E. Mills, Elinor Ochs, Culture and language development, Studies in the social and cultural foundations of language No. 6, Cambridge University Press, 227 + 10 pp. - Denis Monnerie, Frederick H. Damon, Death rituals and life in the societies of the Kula Ring, Dekalb: Northern Illinois University Press, 1989. 280 pp., maps, figs., bibliogr., Roy Wagner (eds.) - Denis Monnerie, Frederick H. Damon, From Muyuw to the Trobriands; Transformations along the northern side of the Kula ring, Tucson: The University of Arizona Press, 1990. xvi + 285 pp., maps, figs., illus., apps., bibliogr., index. - David S. Moyer, Jeremy Boissevain, Dutch dilemmas; Anthropologists look at the Netherlands, Assen/Maastricht: Van Gorcum, 1989, v + 186 pp., Jojada Verrips (eds.) - Gert Oostindie, B.H. Slicher van Bath, Indianen en Spanjaarden; Een ontmoeting tussen twee werelden, Latijns Amerika 1500-1800. Amsterdam: Bert Bakker, 1989. 301 pp. - Parakitri, C.A.M. de Jong, Kompas 1965-1985; Een algemene krant met een katholieke achtergrond binnen het religieus pluralisme van Indonesie, Kampen: Kok, 1990. - C.A. van Peursen, J. van Baal, Mysterie als openbaring. Utrecht: ISOR, 1990. - Harry A. Poeze, R.A. Longmire, Soviet relations with South-East Asia; An historical survey. London-New York: Kegan Paul International, 1989, x + 176 pp. - Harry A. Poeze, Ann Swift, The road to Madiun; The Indonesian communist uprising of 1948. Ithaca, N.Y.: Cornell Modern Indonesia Project (Monograph series 69), 1989, xii + 116 pp. - Alex van Stipriaan, Cornelis Ch. Goslinga, The Dutch in the Caribbean and in Surinam 1791/5 - 1942, Assen/Maastricht: Van Gorcum, 1990. xii + 812 pp. - A. Teeuw, Keith Foulcher, Social commitment in literature and the arts: The Indonesian ‘Institute of People’s culture’ 1950-1965, Clayton, Victoria: Southeast Asian studies, Monash University (Centre of Southeast Asian studies), 1986, vii + 234 pp. - Elly Touwen-Bouwsma, T. Friend, The blue-eyed enemy; Japan against the West in Java and Luzon, 1942-1945. New Jersey: Princeton University press, 1988, 325 pp.
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Gerritsen, Hans, Arie Draaijer e Joseph Lakowicz. "Second International Lifetime Imaging Meeting, Utrecht, The Netherlands, June 14, 1996". Journal of Fluorescence 7, n.º 1 (março de 1997): 1. http://dx.doi.org/10.1007/bf02764570.
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Charlesworth, Hilary. "SIM Peter Baehr lecture 2023: Human rights and the International Court of Justice". Netherlands Quarterly of Human Rights 42, n.º 1 (março de 2024): 116–27. http://dx.doi.org/10.1177/09240519241236505.
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The annual SIM Peter Baehr lecture celebrates the founding of the Netherlands Institute of Human Rights (SIM) in 1981 and commemorates the late Peter Baehr, one of SIM's former directors and an eminent human rights scholar. The 2023 lecture was delivered at Utrecht University on 30 November by Hilary Charlesworth, judge at the International Court of Justice and renowned scholar of international law and human rights.
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van Zutphen, L. F. M., e Stephan van Meulebrouck. "International Course on Laboratory Animal Science – Utrecht, The Netherlands 14–25 May 2001". Veterinary Journal 161, n.º 2 (março de 2001): 212. http://dx.doi.org/10.1053/tvjl.2000.0535.
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Not Available, Not Available. "International course on Laboratory Animal Science - Utrecht, The Netherlands May 15-26, 2000". Archives of Toxicology 73, n.º 8-9 (9 de dezembro de 1999): 499. http://dx.doi.org/10.1007/s002040050643.
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van Meulebrouck, Stephan. "International course on Laboratory Animal Science, Utrecht, The Netherlands, July 9–20, 2007". Archives of Toxicology 81, n.º 1 (23 de novembro de 2006): 73. http://dx.doi.org/10.1007/s00204-006-0156-3.
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van Straalen, Fennie M., e Patrick A. Witte. "LANDac, International Land Governance Conference 2016, 30 June–1 July, Utrecht, the Netherlands". Town Planning Review 88, n.º 2 (março de 2017): 263–67. http://dx.doi.org/10.3828/tpr.2017.15a.
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van Meulebrouck, Stephan. "International course on laboratory animal science, Utrecht, The Netherlands June 12–23, 2006". European Journal of Applied Physiology 96, n.º 3 (26 de novembro de 2005): 337. http://dx.doi.org/10.1007/s00421-005-0092-6.
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Dawson, William J. "Abstracts from the Literature, No. 50". Medical Problems of Performing Artists 26, n.º 1 (1 de março de 2011): 53–55. http://dx.doi.org/10.21091/mppa.2011.1009.
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Once again, the recent performing arts medicine literature contains several articles with a common thread. For this issue, the piano is the subject—four articles, both clinical and research-based, provide further insights into aspects of performance and difficulties that may affect it. A second attribute of this column is the review of several papers from the recent International Symposium on Performance Science, held in Utrecht, Netherlands, in 2009. Installment 50.
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Van Zutphen, L. F. M., e Stephan Van Meulebrouck. "International Course on Laboratory Animal Science—Utrecht, The Netherlands May 27–June 7, 2002". Veterinary Journal 163, n.º 1 (janeiro de 2002): 108. http://dx.doi.org/10.1053/tvjl.2001.0625.
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Verhoeven, Jos T. A. "The 7th Intecol International Wetlands Conference in Utrecht, The Netherlands 25–30 July 2004". Society of Wetland Scientists Bulletin 20, n.º 2 (junho de 2003): 22. http://dx.doi.org/10.1672/0732-9393(2003)020[0022:ttiiwc]2.0.co;2.
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van Gaans, Pauline F. M., e Simon P. Vriend. "Geochemical mapping in the Kingdom of the Netherlands: introduction". Netherlands Journal of Geosciences - Geologie en Mijnbouw 79, n.º 4 (dezembro de 2000): 371–72. http://dx.doi.org/10.1017/s0016774600021879.
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In the beginning of the 1990’s, the Department of Geochemistry of Utrecht University started a series of geochemical surveys of the Leeward Islands of the Antilles that form part of the Kingdom of the Netherlands. Apart from seeking a nice, warm fieldwork environment, the undertaking was motivated by the deficits in infrastructure and financial resources of these islands, which precluded the authorities to undertake such a survey on their own. By then, the International Geological Correlations Programme (IGCP; Darnley et al., 1995) had just been established to address the need for standardised geochemical databases worldwide; the then Geological Survey of the Netherlands (RGD) - now the TNO-Institute of Applied Geosciences (TNO-NITG) - participated in this programme from the start.
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Freestone, David. "International Governance, Responsibility and Management of Areas beyond National Jurisdiction". International Journal of Marine and Coastal Law 27, n.º 2 (2012): 191–204. http://dx.doi.org/10.1163/157180812x633609.
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Abstract This article is a summary of a keynote address given at the Symposium held at the Netherlands Institute for the Law of the Sea at the University of Utrecht on 8 July 2011, the articles from which are collected in this Special Issue. It considers the threats facing the high seas and open ocean, and it considers the defects of the current state of governance of areas beyond national jurisdiction (ABNJ), using the current efforts to protect the Sargasso Sea as an example. It then puts forward the case for the restatement of principles of ocean governance as part of a process within the UN to develop a new instrument to govern ABNJ.
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KITLV, Redactie. "Book Reviews". Bijdragen tot de taal-, land- en volkenkunde / Journal of the Humanities and Social Sciences of Southeast Asia 161, n.º 1 (2005): 143–80. http://dx.doi.org/10.1163/22134379-90003718.
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-Monika Arnez, Niels Mulder, Southeast Asian images; Towards civil society? Chiang Mai: Silkworm Books, 2003, ix + 253 pp. -Adriaan Bedner, Connie Carter, Eyes on the prize; Law and economic development in Singapore. The Hague: Kluwer Law International, xviii + 307 pp. [The London-Leiden series on law, administration and development 7.] -Amrit Gomperts, J.R. van Diessen ,Grote atlas van Nederlands Oost-Indië/Comprehensive atlas of the Netherlands East Indies. Zierikzee: Asia Maior, Utrecht: Koninklijk Nederlands Aardrijkskundig Genootschap (KNAG), 2004, 480 pp. (editors, with the collaboration of R.C.M. Braam, W. Leijnse, P.A. Levi, J.J. Reijnders, R.P.G.A. Voskuil and M.P.B. Ziellemans), F.J. Ormeling (eds) -Stuart R. Harrop, Adriaan Bedner ,Towards integrated environmental law in Indonesia? Leiden: Research school CNWS, School of Asian, African and Amerindian studies, 2003, 161 pp. [CNWS publications 127.], Nicole Niessen (eds) -David Henley, Paul H. Kratoska ,Locating Southeast Asia: Geographies of knowledge and politics of space. Singapore: Singapore University Press, 2005, xi + 326 pp., Remco Raben, Henk Schulte Nordholt (eds) -Gerry van Klinken, Anthony J. Langlois, The politics of justice and human rights; Southeast Asia and universalist theory. Cambridge: Cambridge University Press, 2001, xi + 214 pp. [Cambridge Asia-Pacific studies.] -Koh Keng We, Jurrien van Goor, Prelude to colonialism; The Dutch in Asia. Hilversum: Verloren, 2004, 127 pp. -Lim Beng Soon, Thomas H. Slone, Prokem; An analysis of a Jakartan slang. Oakland: Masalai Press, 2003, 95 pp. -Lim Beng Soon, Neil Khor Jin Keong ,The Penang Po Leung Kuk; Chinese women, prostitution and a welfare organisation. Kuala Lumpur; The Malaysian branch of the Royal Asiatic society (MBRAS), 2004, VII + 181 pp., Khoo Keat Siew (eds) -Dick van der Meij, J. Thomas Lindblad ,Macht en majesteit; Opstellen voor Cees Fasseur bij zijn afscheid als hoogleraar in de geschiedenis van Indonesië aan de Universiteit Leiden. Leiden: Opleiding Talen en Culturen van Zuidoost-Azië en Oceanië, Universiteit Leiden, 2002, xviii + 328 pp. [Semaian 22.], Willem van der Molen (eds) -Dick van der Meij, Renato Rosaldo, Cultural citizenship in island Southeast Asia; Nation and belonging in the hinterlands. Berkeley CA: University of California Press, 2003, x + 228 pp. -Lisa Migo, Sjoerd R. Jaarsma, Handle with care; Ownership and control of ethnographic materials. Pittsburgh: University of Pittsburgh Press, 2002, x + 264 pp. [ASAO monograph series 20.] -Jonathan H. Ping, Priyambudi Sulistiyanto, Thailand, Indonesia and Burma in comparative perspective. Aldershot: Ashgate, 2002, xiv + 308 pp. [The international political economy of new regionalisms series.] -Anthony L. Smith, Amitav Acharya, Constructing a security community in Southeast Asia; ASEAN and the problem of regional order. London: Routledge, 2001, xx + 234 pp. -Achmad Sunjayadi, Elsbeth Locher-Scholten ,Hof en handel; Aziatische vorsten en de VOC 1620-1720. Leiden: KITLV Uitgeverij, 2004, x + 350 pp. [Verhandelingen 223.], Peter Rietbergen (eds) -Gerard Termorshuizen, Marieke Bloembergen, De koloniale vertoning; Nederland en Indië op de wereldtentoonstellingen (1880-1931). Amsterdam: Wereld-bibliotheek, 2002, 463 pp.''Koloniale inspiratie; Frankrijk, Nederland, Indië en de wereldtentoonstellingen 1883-1931. Leiden: KITLV Uitgeverij, 2004, 256 pp. -Jojanneke van der Toorn, Philip Taylor, Goddess on the rise; Pilgrimage and popular religion in Vietnam. Honolulu: University of Hawaii Press, 2004, x + 332 pp. -Holger Warnk, Azyumardi Azra, The origins of Islamic reformism in Southeast Asia; Networks of Malay-Indonesian and Middle Eastern 'ulama' in the seventeenth and eighteenth century. Leiden: KITLV Press, 2004, ix + 253 pp. -Robert Wessing, Gregory Forth, Beneath the volcano; Religion, cosmology and spirit classification among the Nage of eastern Indonesia. Leiden: KITLV Press, 1998, xi + 369 pp. [Verhandelingen 117.] -Edwin Wieringa, Dauril Alden, Charles R. Boxer; An uncommon life: soldier, historian, teacher, collector, traveller. Lisboa: Fundacão Oriente, 2001, 616 pp. (author assisted by James S. Cummins and Michael Cooper)
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Ferguson, Andrew. "Along the Krommerun: The Twenty-Fourth International James Joyce Symposium, Utrecht, The Netherlands, 15-20 June 2014". James Joyce Quarterly 50, n.º 3 (2013): 586–89. http://dx.doi.org/10.1353/jjq.2013.0036.
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Remie, R., I. M. Cuesta Cobo e E. N. Spoelstra. "Microsurgery in the Netherlands, from an experimental pharmacological perspective". Issues of Reconstructive and Plastic Surgery 24, n.º 1 (20 de maio de 2021): 39–47. http://dx.doi.org/10.52581/1814-1471/76/4.
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This paper is dedicated to the memory of Hans Rensema (1948–2020), medical artist of Microsurgical Developments Foundation.The history of training in microsurgical and experimental techniques in the Netherlands goes back to the 1960s. The training was mostly done on an individual basis. Clinical surgeons could benefit from the 'Wet-Lab' training at the Erasmus University of Rotterdam. Experimental microsurgery and techniques training for larger groups of bio-technicians and researchers started at Utrecht University in 1993, and later at Groningen University. The first commercial training was offered at the International Microsurgical Training Centre in Lelystad (IMTC,) in 2002. This paper presents the current state-of-the-art training in the Netherlands and some future perspectives.Professor Remie studied Pharmacy at the University of Groningen. After completing his studies in 1983, he specialised in pharmacology and did his PhD on the presynaptic modulation of noradrenergic neurotransmission in the freely moving rat portal vein. He joined Solvay Pharmaceuticals as a Group leader in Pharmacology, specialized (1991) in Laboratory Animal Science (Utrecht University), and became Laboratory Animal Scientist and Animal Welfare Officer of Solvay Pharmaceuticals and Fort Dodge Animal Health Holland. He is chairman of the Microsurgical Developments Foundation and several IACUCs. From 1997 until 2012, he was appointed professor with a special chair in Microsurgery and Experimental Technique in Laboratory Animals at the Groningen Centre for Drug Research, Department of Biomonitoring & Sensoring, University Centre for Pharmacy, University of Groningen. He is CEO of 3-R's Training Centre BV, and Director of the René Remie Surgical Skills Centre (www.rrssc.eu).Irene Cuesta Cobo earned a BSc in Biology and physiotherapy, and an MSc in manual therapy at the University of Jaén (Spain). She worked at the department of physiology at the same university on an in-vivo assay with gliomas in rats and subsequently, at the Laboratory of CAR Madrid to analyse top athletes' blood samples. She is a senior instructor at RRSSC.Edwin Spoelstra earned an MSc in Pharmacy and specialised stereotaxic surgery and microdialysis in the rat. He developed several techniques in mice and spent the last ten years on catheter design and blood-sampling.
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Senders, Joeky T., Sybren L. N. Maas, Kaspar Draaisma, John J. McNulty, Joanna L. Ashby, Imo Hofer, Wouter W. van Solinge et al. "International practice variation in perioperative laboratory testing in glioblastoma patients—a retrospective cohort study". Acta Neurochirurgica 164, n.º 2 (7 de janeiro de 2022): 385–92. http://dx.doi.org/10.1007/s00701-021-05090-w.
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Abstract Purpose Although standard-of-care has been defined for the treatment of glioblastoma patients, substantial practice variation exists in the day-to-day clinical management. This study aims to compare the use of laboratory tests in the perioperative care of glioblastoma patients between two tertiary academic centers—Brigham and Women’s Hospital (BWH), Boston, USA, and University Medical Center Utrecht (UMCU), Utrecht, the Netherlands. Methods All glioblastoma patients treated according to standard-of-care between 2005 and 2013 were included. We compared the number of blood drawings and laboratory tests performed during the 70-day perioperative period using a Poisson regression model, as well as the estimated laboratory costs per patient. Additionally, we compared the likelihood of an abnormal test result using a generalized linear mixed effects model. Results After correction for age, sex, IDH1 status, postoperative KPS score, length of stay, and survival status, the number of blood drawings and laboratory tests during the perioperative period were 3.7-fold (p < 0.001) and 4.7-fold (p < 0.001) higher, respectively, in BWH compared to UMCU patients. The estimated median laboratory costs per patient were 82 euros in UMCU and 256 euros in BWH. Furthermore, the likelihood of an abnormal test result was lower in BWH (odds ratio [OR] 0.75, p < 0.001), except when the prior test result was abnormal as well (OR 2.09, p < 0.001). Conclusions Our results suggest a substantially lower clinical threshold for ordering laboratory tests in BWH compared to UMCU. Further investigating the clinical consequences of laboratory testing could identify over and underuse, decrease healthcare costs, and reduce unnecessary discomfort that patients are exposed to.
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Jancev, Milena, Frank J. Snoek, Geert W. J. Frederix, Heleen Knottnerus, Helga Blauw, Maureen Witkop, Karel G. M. Moons et al. "Dual hormone fully closed loop in type 1 diabetes: a randomised trial in the Netherlands – study protocol". BMJ Open 13, n.º 8 (agosto de 2023): e074984. http://dx.doi.org/10.1136/bmjopen-2023-074984.
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IntroductionThe management of type 1 diabetes (T1DM) has undergone significant advancements with the availability of novel technologies, notably continuous and flash glucose monitoring (CGM and FGM, respectively) and hybrid closed loop (HCL) therapy. The dual hormone fully closed loop (DHFCL) approach with insulin and glucagon infusion has shown promising effects in small studies on glycaemic regulation and quality of life in T1DM.Methods and analysisThe Dual Hormone Fully Closed Loop for Type 1 Diabetes (DARE) study is a non-commercial 12-month open-label, two-arm randomised parallel-group trial. The primary aim of this study is to determine the long-term effects on glycaemic control, patient-reported outcome measurements and cost-effectiveness of the DHFCL compared with usual care, that is, HCL or treatment with multiple daily insulin injections+FGM/CGM. We will include 240 adult patients with T1DM in 14 hospitals in the Netherlands. Individuals will be randomised 1:1 to the DHFCL or continuation of their current care.Ethics and disseminationEthical approval has been obtained from the Medical Research Ethics Committee NedMec, Utrecht, the Netherlands. Findings will be disseminated through peer-reviewed publications and presentations at local, national and international conferences.Trial registration numberNCT05669547.
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Hoek, Wim Z. "The interactions between Quaternary Geology and Archaeology". Netherlands Journal of Geosciences - Geologie en Mijnbouw 89, n.º 1 (julho de 2010): 1–2. http://dx.doi.org/10.1017/s0016774600000779.
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This special issue focuses on the interactions between Quaternary Geology and Archaeology and results from the INQUA-NL Symposium: ‘Late Quaternary Climate Change: a Human Perspective’ held on April 14th2009, KNAW Trippenhuis, Amsterdam. The symposium was attended by over 125 scientists and students with interest in the fields of Quaternary Geology and Archaeology. The symposium was organized for the INQUA Netherlands commission (INQUA-NL) by Wim Hoek, Faculty of Geosciences, Utrecht University (UU), Henry Hooghiemstra, Faculty of Science, University of Amsterdam (UvA), and Jos Deeben, National Service for Cultural Heritage (RCE). The INQUA Netherlands commission (INQUA-NL) is the Netherlands' national representation in INQUA, the International Union for Quaternary Research (see furtherwww.geo.uu.nl/inqua-nl).The Netherlands is a country made by humans, but before the large-scale impact of humans that formed the typical Dutch landscape, people inhabited our area and needed to be able to deal with natural disasters like climate change, river floods or sea-level change. In the field of archaeology, there is increasingly more space to include the environmental changes that partly determined the behaviour of prehistoric communities. The interactions between quaternary geology and archaeology are not only restricted to provide stratigraphical information during archaeological prospection or on exposures during excavations. Quaternary geology is increasingly applied to gain insight in the landscape development and environmental setting where people have lived in the past. Above this, predictive models can be improved by the interaction of archaeological and geological/palaeogeographical research (see also Deeben et al., 2010).
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Karstens, Simon. "A New Old Reign: How Traditional Privileges and Old Laws Established Austrian Rule in the Southern Netherlands after 1713". Central European History 55, n.º 3 (setembro de 2022): 355–71. http://dx.doi.org/10.1017/s0008938921001345.
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AbstractHow did early modern sovereigns establish authority over newly acquired territories? This is the question behind this article which examines the beginning of Austrian rule in the Southern Netherlands after the Peace of Utrecht 1713. Transfers of sovereignty like these marked the end of international conflicts and lead to the change or reinforcement of the social and political order within affected territories. Therefore, their analysis offers new insight into early modern state building. To achieve this, the article first offers an overview of the events before and after the transfer of sovereignty. This is followed by a closer look at the vital role of the relationship between the local church and the new ruler. Finally, a spotlight will be cast on a tax called Pain d'Abbaye, which serves as a example for an empowering interaction that helped to create a stable relationship between the new Lord and his new subjects.
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Schaufeli, Wilmar B., Akihito Shimazu, Jari Hakanen, Marisa Salanova e Hans De Witte. "An Ultra-Short Measure for Work Engagement". European Journal of Psychological Assessment 35, n.º 4 (julho de 2019): 577–91. http://dx.doi.org/10.1027/1015-5759/a000430.
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Abstract. The current study introduces an ultra-short, 3-item version of the Utrecht Work Engagement Scale. Using five national samples from Finland ( N = 22,117), Japan ( N = 1,968), the Netherlands ( N = 38,278), Belgium/Flanders ( N = 5,062), and Spain ( N = 10,040) its internal consistency and factorial validity vis-à-vis validated measures of burnout, workaholism, and job boredom are demonstrated. Moreover, the UWES-3 shares 86–92% of its variance with the longer nine-item version and the pattern of correlations of both versions with 9 indicators of well-being, 8 job demands, 10 job resources, and 6 outcomes is highly similar with an average, absolute difference between correlations of only .02. Hence, it is concluded that the UWES-3 is a reliable and valid indicator of work engagement that can be used as an alternative to the longer version, for instance in national and international epidemiological surveys on employee’s working conditions.
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Joosten, Linda P. T., Sander van Doorn, Arno W. Hoes, Melchior C. Nierman, Nynke M. Wiersma, Huiberdina L. Koek, Martin E. W. Hemels et al. "Safety of switching from vitamin K antagonist to non-vitamin K antagonist oral anticoagulant in frail elderly with atrial fibrillation: rationale and design of the FRAIL-AF randomised controlled trial". BMJ Open 9, n.º 12 (dezembro de 2019): e032488. http://dx.doi.org/10.1136/bmjopen-2019-032488.
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IntroductionClinical guidelines recommend non-vitamin K antagonist oral anticoagulants (NOACs) over vitamin K antagonists (VKAs) for stroke prevention in most patients with atrial fibrillation (AF). Frail elderly were under-represented in the landmark NOAC-trials, leaving a knowledge gap on the optimal anticoagulant management (VKA or NOAC) in this increasing population. The aim of the Frail-AF (FRAIL-AF) study is to assess whether switching from international normalised ratio (INR)-guided VKA-management to a NOAC-based treatment strategy compared with continuing VKA-management is safe in frail elderly patients with AF.Methods and analysisThe FRAIL-AF study is a pragmatic, multicentre, open-label, randomised controlled clinical trial. Frail elderly (age ≥75 years plus a Groningen Frailty Indicator score ≥3) who receive VKA-treatment for AF in the absence of a mechanical heart valve or severe mitral valve stenosis will be randomised to switch to a NOAC-based treatment strategy or to continue INR-guided VKA-management. Patients with severe renal impairment (estimated glomerular filtration rate <30 mL/min/1.73 m2) will be excluded from randomisation. Based on existing trial evidence in non-frail patients, we will aim to explore whether NOAC-treatment is superior to VKA-therapy in reducing major or clinically relevant non-major bleeding events. Secondary outcomes include minor bleeding, the composite of ischaemic and haemorrhagic stroke, health-related quality of life and cost-effectiveness. The follow-up period for all subjects is 12 months.Ethics and disseminationThe protocol was approved by the Medical Research Ethics Committee of the University Medical Center Utrecht, the Netherlands and by the Central Committee on Research Involving Human Subjects, the Netherlands. All patients are asked written informed consent. Results are expected in 2022 and will be disseminated through peer-reviewed journals as well as presentations at national and international conferences.Trial registration numberEudraCT: 2017-000393-11; The Netherlands Trial Registry: 6721 (FRAIL-AF study).
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de Valk, J. P. "Sources for the History of the Dutch Colonies in the Ecclesiastical Archives of Rome (1814–1903)". Itinerario 9, n.º 1 (março de 1985): 53–66. http://dx.doi.org/10.1017/s0165115300003430.
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The source material for the history of Catholic missionary activities in the Dutch colonies during the last century is hardly available in much abundance in the mother country. The Dutch archivist and bibliographer, Marius Roessingh, had to make do in his U.N.E.S.C.O. archival guide on Netherlandish Latin American materials with a “memorandum,” in which he signalled utility of the Vatican archives. Another author in the same series, Frits Jaquet, in his second volume on Asia and Oceania, could be more explicit: he pointed to the materials kept in the state archives at Utrecht, in the Catholic Documentation Centre at Nijmegen University, and in various ecclesiastical archives. In nearly all cases, his emphasis falls within the first half of the 20th century. Such is also true with the detailed survey of materials available in the Catholic Documentation Centre that was featured two years ago in Itinerario, with only one important exception: the archive of the apostolic prefecture, later Apostolic Vicarate of Batavia (1807–1949, on microfiche), that obviously forms an essential source for the mission history of the Netherlands Indies.
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Wang, Xiaomei, e Hans Van de Velde. "Constructing Identities through Multilingualism and MultiscriptualismThe Linguistic Landscape in Dutch and Belgian Chinatowns多元语言文字中的认同建构——以荷兰、比利 时唐人街的语言风貌为例". Journal of Chinese Overseas 11, n.º 2 (27 de outubro de 2015): 119–45. http://dx.doi.org/10.1163/17932548-12341302.
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This paper examines characteristics of the linguistic landscape (ll) in Chinatowns in Belgium and the Netherlands. Fieldwork was conducted in four cities in the Netherlands (Amsterdam, Utrecht, The Hague, and Rotterdam) and two in Belgium (Brussels and Antwerp). All these cities are situated in the Dutch language area, but Brussels is officially bilingual French-Dutch. In the study, the traditional approach in linguistic landscape studies was combined with an ethnographic approach, in which shopkeepers were interviewed about language and script choice in their signs. The quantitative analysis shows that Chinese shows up in more than three quarters of all signs and that in almost 60 per cent of the signs Chinese is the dominant language. Dutch (the language of the region) and English (the international language) show up in almost half the signs. French shows up almost exclusively in Brussels, where Dutch is less used in signs. The analysis also shows interesting differences in script types between the cities. The presence of different types of Chinese character and pinyin systems indexes the Chineseness of the community, the origin of the local Chinese population, the position of the different establishments in the host countries, and the tendency of these Chinese immigrants to localize. We will show how these small overseas-Chinese communities construct and express their new identity by means of multilingualism and multiscriptualism.
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Hulsbergen, Alexander F. C., Sandra C. Yan, Brittany M. Stopa, Aislyn DiRisio, Joeky T. Senders, Max J. van Essen, Stéphanie M. E. van der Burgt, Timothy R. Smith, William B. Gormley e Marike L. D. Broekman. "International practice variation in postoperative imaging of chronic subdural hematoma patients". Journal of Neurosurgery 131, n.º 6 (dezembro de 2019): 1912–19. http://dx.doi.org/10.3171/2018.8.jns181767.
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OBJECTIVEThe value of CT scanning after burr hole surgery in chronic subdural hematoma (CSDH) patients is unclear, and practice differs between countries. At the Brigham and Women’s Hospital (BWH) in Boston, Massachusetts, neurosurgeons frequently order routine postoperative CT scans, while the University Medical Center Utrecht (UMCU) in the Netherlands does not have this policy. The aim of this study was to compare the use of postoperative CT scans in CSDH patients between these hospitals and to evaluate whether there are differences in clinical outcomes.METHODSThe authors collected data from both centers for 391 age- and sex-matched CSDH patients treated with burr hole surgery between January 1, 2002, and July 1, 2016, and compared the number of postoperative scans up to 6 weeks after surgery, the need for re-intervention, and postoperative neurological condition.RESULTSBWH patients were postoperatively scanned a median of 4 times (interquartile range [IQR] 2–5), whereas UMCU patients underwent a median of 0 scans (IQR 0–1, p < 0.001). There was no significant difference in the number of re-operations (20 in the BWH vs 27 in the UMCU, p = 0.34). All re-interventions were preceded by clinical decline and no recurrences were detected on scans performed on asymptomatic patients. Patients’ neurological condition was not worse in the UMCU than in the BWH (p = 0.43).CONCLUSIONSWhile BWH patients underwent more scans than UMCU patients, there were no differences in clinical outcomes. The results of this study suggest that there is little benefit to routine scanning in asymptomatic patients who have undergone surgical treatment of uncomplicated CSDH and highlight opportunities to make practice more efficient.
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van Baarsen, Kirsten, Mariam Slot, Peter Woerdeman, Sen Han e Eelco Hoving. "SURG-16. Pediatric oncology neurosurgery, four years after centralization in the Princess Máxima Center". Neuro-Oncology 24, Supplement_1 (1 de junho de 2022): i145. http://dx.doi.org/10.1093/neuonc/noac079.534.
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Abstract INTRODUCTION: In 2018, the Princess Máxima Center officially opened its doors as a national referral center for pediatric oncology in the Netherlands. This centralization of pediatric oncology also reshaped the pediatric neurosurgery landscape. Almost four years after centralization it is time to make up the balance. METHODS: From the start in May 2018, a predesigned database was kept for all neurosurgical procedures performed in the Princess Máxima Center, Utrecht. Data was collected by a well-trained medical student and under close supervision of a pediatric neurosurgeon. Patient demographic data, tumor data (location, pathology), surgical data (approach, intended and obtained extent of resection), radiology data, and follow up data (complications, functional outcome) were collected. PRELIMINARY RESULTS: From May 2018 to December 2021, 783 oncology related surgeries have been performed in 472 individual patients (56% male; mean age 8 years). There were 316 cranial tumor resections, 279 of which were first resections. Pilocytic astrocytoma was the most frequent diagnosis (38%), followed by medulloblastoma (14%) and ependymoma (11%). Among the more rare tumors there were 29 diffuse midline gliomas and 29 craniopharyngiomas, reflecting the high volume after centralization. The extent of tumor resection and Clavien Dindo complication grading are correlated to time after centralization. CONCLUSION: Four years after the start of centralization, the pediatric oncology neurosurgery service in the Netherlands is well established. Clustering has resulted in high absolute numbers, even for rare tumor types, and growing experience. With this series we hope to create an international benchmark for pediatric oncology neurosurgery.
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Pine, Alexander B., Ayesha Butt, Rolando Garcia-Milian, Sean X. Gu, Valentina Restrepo, Yu Pei Chock, John Hwa et al. "Proteomic Profiling of Different Antiphospholipid Antibody-Positive Phenotypes: Results from Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking (APS ACTION) Registry". Blood 142, Supplement 1 (28 de novembro de 2023): 2575. http://dx.doi.org/10.1182/blood-2023-185232.
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Background. Antiphospholipid syndrome (APS) is an autoimmune disease with thrombotic and obstetric complications arising via a model of immunothrombosis. Patients may present with a spectrum of phenotypes, including thrombotic (tAPS), obstetric (oAPS), or catastrophic/microvascular APS (C/MAPS), while others may have antiphospholipid antibodies (aPL) without disease manifestations. The mechanisms underlying the development of these diverse phenotypes remain uncertain. Proteomic profiling was used in other thrombotic and microvascular disorders to highlight potential mechanisms of disease pathogenesis and may have a role in understanding the pathophysiology of APS. We performed multiplex plasma proteomic profiling in aPL-positive patients with different clinical phenotypes to gain a greater understanding of potential immunothrombotic mechanisms in the pathogenesis of APS. Methods. We utilized samples from APS ACTION Registry. The inclusion criteria were positive aPL per Updated Sapporo Classification Criteria tested within one year prior to the enrollment. Multiplex proteomic profiling measuring approximately 7,000 unique proteins (SomaLogic; Boulder, CO, USA) was performed on 40 primary aPL-positive patient plasma samples (10 each of tAPS with/without oAPS, oAPS only, C/MAPS, and positive aPL without APS classification), and 10 of healthy controls. Differentially abundant proteins among all phenotypic groups and in pairwise comparisons were determined by applying ANOVA and t-tests to log-normalized data, respectively, with p-values <0.05 considered statistically significant (Qlucore Omics Explorer, Lund, Sweden). Tests were adjusted for false discovery (q<0.1) to minimize the likelihood of false positives. Pathway enrichment analysis was performed using Metascape (https://metascape.org) and Ingenuity IPA (Qiagen, Venlo, Netherlands) platforms. Results. The median age of patients was 48 years; 30% were men, 70% had triple aPL-positivity, and no one had a concurrent diagnosis of lupus. A set of concordant and differentially abundant proteins clustered patients with 4 APS clinical phenotypes and controls (Figure A) with a high statistical significance (p<0.0007) and a high false discovery confidence (q<0.05). Proteins in the identified set belonged to several highly enriched pathways such as neutrophil degranulation (p<10 -10), humoral immune response (p<10 -9), coagulation (p<10 -6), and alternative complement (p<10 -5) [data not shown]. Pathway enrichment analysis of protein sets identified in pairwise comparisons of APS phenotypes (aPL vs C/MAPS, aPL vs tAPS, tAPS vs C/MAPS) revealed involvement of several common pathways associated with inflammation, collagen and fibroblast signaling, cellular and cytoskeletal activation, humoral immune response, myeloid and effector cell differentiation and recruitment, and immunothrombosis such as Pathogen-Induced Cytokine Storm, Neutrophil Extracellular Trap (NET), and collagen-induced platelet-activating GP6 signaling (Figure B). For several pathways, the measure of activation related to increased or predicted to be increased proteins annotated within a particular pathway positively correlated with the clinical “distance” between APS subtypes, from the most clinically related C/MAPS vs tAPS to the most distant aPL vs C/MAPS suggesting an “evolution” from one phenotype to a more severe in terms of activation of specific pathways. Specifically notable is the higher activation of the NET signaling pathway in the aPL than in C/MAPS phenotype suggesting that the presence of aPL antibodies activates this immunothrombotic pathway. Conclusions. Plasma proteome of APS subtypes is characterized by alteration in several cellular processes, particularly receptor signaling, signal transduction, regulation of cellular differentiation, neutrophil, complement, coagulation and cytokine activation notable in all individuals with aPL-positivity. Pathways activated in the non-thrombotic (aPL) phenotype and escalating activation of several pathways from non-thrombotic to the most thrombotic (C/MAPS) phenotype provide important data for the understanding of APS pathogenesis and informing the model of APS-related immunothrombosis.
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Willemsen, Anna C. H., Annemieke Kok, Laura W. J. Baijens, J. P. De Boer, Remco de Bree, Lot Devriese, Chantal M. L. Driessen et al. "Update and external validation of a multivariable prediction model for tube feeding dependency for at least four weeks during chemoradiotherapy for head and neck cancer." Journal of Clinical Oncology 39, n.º 15_suppl (20 de maio de 2021): 6040. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.6040.
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6040 Background: Patients who receive chemoradiation or bioradiation (CRT/BRT) for locally advanced head and neck squamous cell carcinoma (LAHNSCC) often experience high toxicity rates, which may interfere with oral intake, leading to (temporary) tube feeding (TF) dependency. International guidelines recommend gastrostomy insertion when the expected use of TF exceeds four weeks. In this study we aimed to update and externally validate a prediction model to identify patients in need for TF for at least four weeks, meeting the international criteria for prophylactic gastrostomy insertion. Methods: This retrospective multicenter cohort study was performed in four tertiary referral head and neck cancer centers in the Netherlands. The prediction model was developed using data from the University Medical Center Utrecht and the Netherlands Cancer Institute. The model was externally validated in patients from the Maastricht University Medical Center and Radboud University Medical Center. The primary endpoint was TF, initiated during or within 30 days after completion of CRT/BRT, and administered for at least four weeks. Potential predictors were retrieved from patient medical records and radiotherapy dose-volume parameters were calculated. Results: The developmental and validation cohort included 409 and 334 patients respectively. Multivariable analysis showed significant predictive value (p < 0.05) for adjusted diet at start of CRT/BRT, percentage weight change prior to treatment initiation, WHO performance status, tumor-site, nodal stage, mean radiation dose to the contralateral parotid gland, and mean radiation dose to the oral cavity. The area under the receiver operating characteristics curve for the updated model was 0.73 and after external validation 0.64. Positive and negative predictive value at 90% cut off were 80.0% and 48.2% respectively. Conclusions: This externally validated prediction model to estimate TF-dependency for at least four weeks in LAHNSCC patients performs well. This model, which will be presented, can be used in clinical practice to guide personalized decision making on prophylactic gastrostomy insertion.
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Leeuw, Laura de, e Martijn Groenleer. "The Regional Governance of Energy-Neutral Housing: Toward a Framework for Analysis". Sustainability 10, n.º 10 (16 de outubro de 2018): 3726. http://dx.doi.org/10.3390/su10103726.
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Regions are expected to play a key role in realizing international, European, and national climate and energy goals. Also regions in the Netherlands are working toward these goals, taking initiatives toward an energy-neutral built environment by 2050. However, it remains unclear how such efforts and other socially innovative activities can best be described and how variation between them in terms of governance can be explained. In this article, we develop a framework for analyzing the governance of regional energy-neutral housing initiatives. We ask what factors shape regional climate and energy governance, particularly regional efforts to increase the efficiency of urban dwellings. We answer this question using a subnational comparative method and a most similar case design, focusing on three Dutch regions: Utrecht, Noord-Brabant and Drenthe. Based on document analysis and 24 semi-structured interviews, we find that the regional governance of energy-neutral housing initiatives is primarily driven by existing social networks in the regions, and less determined by local characteristics of the built environment. Thus, regional governance seems to have generated solutions that are supported by regional actors. Nonetheless, as these solutions are not entirely tailored to the regional situation, functionally speaking, a key question for future research is how effective these solutions will be.
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Dibbets, Alicia, Quirine A. M. Eijkman, Dorien Claessen e Majda Lamkaddem. "Social Workers as Local Human Rights Actors? Their Response to Barriers in Access to Care and Support in the Netherlands". Journal of Human Rights Practice 13, n.º 1 (1 de fevereiro de 2021): 105–23. http://dx.doi.org/10.1093/jhuman/huab013.
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Abstract The realization of human rights standards depends in part on the commitment of local actors. It can be argued that local public service professionals such as social workers can also be regarded as key players. The possible role of social workers becomes imperative if these professionals are working in a policy context that is not congruent with human rights. If existing laws or policies cause or maintain disrespect for human rights, social workers are in a position to observe that this is having an adverse impact on clients. When social workers are regarded as human rights actors, the question arises how they can or should respond to law and policy that impedes them in carrying out their work with respect for human rights. This article adds to existing theories on social workers as human rights actors by examining the practices of social professionals working in such a challenging policy context. The research took place among professionals in social district teams in the city of Utrecht, the Netherlands. Following a series of decentralizations and austerity measures the social care landscape in the Netherlands has changed drastically over the last few years. As a result, social workers may find themselves on the one hand trying to realize the best possible care for their clients while on the other hand dealing with new laws and policy expectations focused on self-reliance and diminished access to specialist care. The article explores how social professionals’ responses to barriers in access to care affect human rights requirements. In doing so, this socio-legal study provides insight into the ways in which everyday social work relates to the realization of human rights at the local level.
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van Spreuwel, Peggy C. J. M., Katarina Jerković-Ćosić, Cor van Loveren e Geert J. M. G. van der Heijden. "Oral Health Coaches at Well-Baby Clinics to Promote Oral Health in Preschool Children From the First Erupted Tooth: Protocol for a Multisite, Pragmatic Randomized Controlled Trial". JMIR Research Protocols 11, n.º 8 (31 de agosto de 2022): e39683. http://dx.doi.org/10.2196/39683.
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Background Early childhood caries is considered one of the most prevalent diseases in childhood, affecting almost half of preschool-age children globally. In the Netherlands, approximately one-third of children aged 5 years already have dental caries, and dental care providers experience problems reaching out to these children. Objective Within the proposed trial, we aim to test the hypothesis that, compared to children who receive usual care, children who receive the Toddler Oral Health Intervention as add-on care will have a reduced cumulative caries incidence and caries incidence density at the age of 48 months. Methods This pragmatic, 2-arm, individually randomized controlled trial is being conducted in the Netherlands and has been approved by the Medical Ethics Research Board of University Medical Center Utrecht. Parents with children aged 6 to 12 months attending 1 of the 9 selected well-baby clinics are invited to participate. Only healthy children (ie, not requiring any form of specialized health care) with parents that have sufficient command of the Dutch language and have no plans to move outside the well-baby clinic region are eligible. Both groups receive conventional oral health education in well-baby clinics during regular well-baby clinic visits between the ages of 6 to 48 months. After concealed random allocation of interventions, the intervention group also receives the Toddler Oral Health Intervention from an oral health coach. The Toddler Oral Health Intervention combines behavioral interventions of proven effectiveness in caries prevention. Data are collected at baseline, at 24 months, and at 48 months. The primary study endpoint is cumulative caries incidence for children aged 48 months, and will be analyzed according to the intention-to-treat principle. For children aged 48 months, the balance between costs and effects of the Toddler Oral Health Intervention will be evaluated, and for children aged 24 months, the effects of the Toddler Oral Health Intervention on behavioral determinants, alongside cumulative caries incidence, will be compared. Results The first parent-child dyads were enrolled in June 2017, and recruitment was finished in June 2019. We enrolled 402 parent-child dyads. Conclusions All follow-up interventions and data collection will be completed by the end of 2022, and the trial results are expected soon thereafter. Results will be shared at international conferences and via peer-reviewed publication. Trial Registration Netherlands Trial Register NL8737; https://trialsearch.who.int/Trial2.aspx?TrialID=NL8737 International Registered Report Identifier (IRRID) DERR1-10.2196/39683
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van de Meent, Mette, Dianne G. Kleuskens, Wessel Ganzevoort, Sanne J. Gordijn, Elisabeth M. W. Kooi, Wes Onland, Bas B. van Rijn et al. "OPtimal TIming of antenatal COrticosteroid administration in pregnancies complicated by early-onset fetal growth REstriction (OPTICORE): study protocol of a multicentre, retrospective cohort study". BMJ Open 13, n.º 3 (março de 2023): e070729. http://dx.doi.org/10.1136/bmjopen-2022-070729.
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IntroductionEarly-onset fetal growth restriction (FGR) requires timely, often preterm, delivery to prevent fetal hypoxia causing stillbirth or neurologic impairment. Antenatal corticosteroids (CCS) administration reduces neonatal morbidity and mortality following preterm birth, most effectively when administered within 1 week preceding delivery. Optimal timing of CCS administration is challenging in early-onset FGR, as the exact onset and course of fetal hypoxia are unpredictable. International guidelines do not provide a directive on this topic. In the Netherlands, two timing strategies are commonly practiced: administration of CCS when the umbilical artery shows (A) a pulsatility index above the 95thhcentile and (B) absent or reversed end-diastolic velocity (a more progressed disease state). This study aims to (1) use practice variation to compare CCS timing strategies in early-onset FGR on fetal and neonatal outcomes and (2) develop a dynamic tool to predict the time interval in days until delivery, as a novel timing strategy for antenatal CCS in early-onset FGR.Methods and analysisA multicentre, retrospective cohort study will be performed including pregnancies complicated by early-onset FGR in six tertiary hospitals in the Netherlands in the period between 2012 and 2021 (estimated sample size n=1800). Main exclusion criteria are multiple pregnancies and fetal congenital or genetic abnormalities. Routinely collected data will be extracted from medical charts. Primary outcome for the comparison of the two CCS timing strategies is a composite of perinatal, neonatal and in-hospital mortality. Secondary outcomes include the COSGROVE core outcome set for FGR. A multivariable, mixed-effects model will be used to compare timing strategies on study outcomes. Primary outcome for the dynamic prediction tool is ‘days until birth’.Ethics and disseminationThe need for ethical approval was waived by the Ethics Committee (University Medical Center Utrecht). Results will be published in open-access, peer-reviewed journals and disseminated by presentations at scientific conferences.Trial registration numberClinicalTrials.gov:NCT05606497
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de Sévaux, Joline L. H., Roger A. M. J. Damoiseaux, Saskia Hullegie, Elisabeth A. M. Sanders, G. Ardine de Wit, Nicolaas P. A. Zuithoff, Lucy Yardley et al. "Effectiveness of analgesic ear drops as add-on treatment to oral analgesics in children with acute otitis media: study protocol of the OPTIMA pragmatic randomised controlled trial". BMJ Open 13, n.º 2 (fevereiro de 2023): e062071. http://dx.doi.org/10.1136/bmjopen-2022-062071.
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IntroductionEar pain is the most prominent symptom of childhood acute otitis media (AOM). To control the pain and reduce reliance on antibiotics, evidence of effectiveness for alternative interventions is urgently needed. This trial aims to investigate whether analgesic ear drops added to usual care provide superior ear pain relief over usual care alone in children presenting to primary care with AOM.Methods and analysisThis is a pragmatic, two-arm, individually randomised, open, superiority trial with cost-effectiveness analysis and nested mixed-methods process evaluation in general practices in the Netherlands. We aim to recruit 300 children aged 1–6 years with a general practitioner (GP) diagnosis of AOM and ear pain. Children will be randomly allocated (ratio 1:1) to either (1) lidocaine hydrochloride 5 mg/g ear drops (Otalgan) one to two drops up to six times daily for a maximum of 7 days in addition to usual care (oral analgesics, with/without antibiotics); or (2) usual care. Parents will complete a symptom diary for 4 weeks as well as generic and disease-specific quality of life questionnaires at baseline and 4 weeks. The primary outcome is the parent-reported ear pain score (0–10) over the first 3 days. Secondary outcomes include proportion of children consuming antibiotics, oral analgesic use and overall symptom burden in the first 7 days; number of days with ear pain, number of GP reconsultations and subsequent antibiotic prescribing, adverse events, complications of AOM and cost-effectiveness during 4-week follow-up; generic and disease-specific quality of life at 4 weeks; parents’ and GPs’ views and experiences with treatment acceptability, usability and satisfaction.Ethics and disseminationThe Medical Research Ethics Committee Utrecht, the Netherlands, has approved the protocol (21-447/G-D). All parents/guardians of participants will provide written informed consent. Study results will be submitted for publication in peer-reviewed medical journals and presented at relevant (inter)national scientific meetings.Trial registrationThe Netherlands Trial Register: NL9500; date of registration: 28 May 2021. At the time of publication of the study protocol paper, we were unable to make any amendments to the trial registration record in the Netherlands Trial Register. The addition of a data sharing plan was required to adhere to the International Committee of Medical Journal Editors guidelines. The trial was therefore reregistered in ClinicalTrials.gov (NCT05651633; date of registration: 15 December 2022). This second registration is for modification purposes only and the Netherlands Trial Register record (NL9500) should be regarded as the primary trial registration.
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Hosney, Mohamed, Abeer M. Badr, Sohair R. Fahmy, Ahmed Afifi, Vera Baumans e Khadiga M. Gaafar. "Culture of Care Enhancement in Egypt: The Impact of Laboratory Animal Science Training on Participants’ Attitudes". Alternatives to Laboratory Animals 49, n.º 1-2 (janeiro de 2021): 49–55. http://dx.doi.org/10.1177/02611929211016851.
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Cairo University was the first academic institution in Egypt to establish an Institutional Animal Care and Use Committee (IACUC), as mandated by the World Organisation for Animal Health (OIE). Animal-based research should be performed in accordance with international regulations to monitor the humane care and use of the laboratory animals. Until 2018, the formal training of researchers in the appropriate and correct methods of animal handling during sampling and administration, as well as their husbandry demands, was an uncommon practice in Egypt. In 2018, the Egyptian Association for Animal Research Advancement (EAARA) organised the first international course in laboratory animal science (LAS), in collaboration with Utrecht University (The Netherlands) and the Faculty of Science, Cairo University, to raise researchers’ awareness and increase their knowledge of the principles that govern the humane use and care of laboratory animals. A total of 26 researchers from a number of fields (veterinary medicine, dentistry, science, medicine, pharmacy and agriculture) enrolled in the course. In the responses to the post-course questionnaire, 24 (92.3%) participants stated that the principles of animal welfare (Three Rs) were well explained. In addition, 18 (69%) participants found that the course improved their skills in animal sampling and handling. Of the 26 participants, 22 (84.6%) became aware of their responsibility towards their experimental animals and agreed that the different methods of euthanasia were well explained. In conclusion, the general assessment of the course revealed a positive outcome regarding the culture of animal care; the course was repeated a year later, and several participants were enlisted as trainers in this second course.
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Simons, Michelle V., Marijn H. A. Groen, Gert J. de Borst, Tim Leiner, Pieter A. F. Doevendans, Emad Ebbini, Fons J. B. Slieker, René van Es e Constantijn E. V. B. Hazenberg. "Safety and feasibility study of non-invasive robot-assisted high-intensity focused ultrasound therapy for the treatment of atherosclerotic plaques in the femoral artery: protocol for a pilot study". BMJ Open 12, n.º 5 (maio de 2022): e058418. http://dx.doi.org/10.1136/bmjopen-2021-058418.
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IntroductionPeripheral arterial disease (PAD) is an atherosclerotic disease leading to stenosis and/or occlusion of the arterial circulation of the lower extremities. The currently available revascularisation methods have an acceptable initial success rate, but the long-term patency is limited, while surgical revascularisation is associated with a relatively high perioperative risk. This urges the need for development of less invasive and more effective treatment modalities. This protocol article describes a study investigating a new non-invasive technique that uses robot assisted high-intensity focused ultrasound (HIFU) to treat atherosclerosis in the femoral artery.Methods and analysisA pilot study is currently performed in 15 symptomatic patients with PAD with a significant stenosis in the common femoral and/or proximal superficial femoral artery. All patients will be treated with the dual-mode ultrasound array system to deliver imaging-guided HIFU to the atherosclerotic plaque. Safety and feasibility are the primary objectives assessed by the technical feasibility of this therapy and the 30-day major complication rate as primary endpoints. Secondary endpoints are angiographic and clinical success and quality of life.Ethics and disseminationEthical approval for this study was obtained in 2019 from the Medical Ethics Committee of the University Medical Center Utrecht, the Netherlands. Data will be presented at national and international conferences and published in a peer-reviewed journal.Trial registration numberNL7564.
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Liu, Dan, Siqi Che e Wenzhong Zhu. "Visualizing the Knowledge Domain of Academic Mobility Research from 2010 to 2020: A Bibliometric Analysis Using CiteSpace". SAGE Open 12, n.º 1 (janeiro de 2022): 215824402110685. http://dx.doi.org/10.1177/21582440211068510.
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Academic mobility, given its importance in the dissemination of knowledge and globalization of research collaboration, has received growing attention over the past decades. Based on a bibliometric analysis of the literature on academic mobility (119) from 343 journal articles in Web of Science over the period of 2010 to 2020 with the use of CiteSpace, this paper outlines the research intellectual map, such as the most active contemporary institutions, journals, and popular regions/countries; dissects the network of categories and summarizes the emerging trends and future research opportunities for academic mobility. The results of the study are: (1) England is the most productive region followed by China and Netherlands in terms of publication; (2) Utrecht University, The Polytechnic University of Valencia, and Russian Academy of Science are the most productive institutions; (3) The publications are mainly in the subject categories of Education, Business and Economics, and Geography; (4) Gender, scientific practice, brain drain are the main keywords for discussion; and (5) Louise Ackers is the most influential author in this field and International Migration Journal is the most frequently cited journal over the past decade. Our paper contributes to the relevant body of literature by systematizing the literature on academic mobilities through CiteSpace, a visualized analytical tool for undertaking bibliometric analysis, providing valuable references for researchers and practitioners who want to further explore this knowledge area.
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Citron, Marcia J. "Beyond Biography: Seventh International Congress on Women in Music Utrecht, The Netherlands 29 May-2 June 1991. Music and Gender Conference King's College, London 5-7 July 1991". Journal of Musicology 9, n.º 4 (1991): 533–43. http://dx.doi.org/10.2307/763875.
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Citron, Marcia J. "Beyond Biography: Seventh International Congress on Women in Music Utrecht, The Netherlands 29 May-2 June 1991. Music and Gender Conference King's College, London 5-7 July 1991". Journal of Musicology 9, n.º 4 (outubro de 1991): 533–43. http://dx.doi.org/10.1525/jm.1991.9.4.03a00080.
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Groenewegen, Amy, Victor W. Zwartkruis, Michiel Rienstra, Monika Hollander, Hendrik Koffijberg, Maarten Jan Maria Cramer, Yvonne T. van der Schouw, Arno W. Hoes, Rudolf A. de Boer e Frans H. Rutten. "Improving early diagnosis of cardiovascular disease in patients with type 2 diabetes and COPD: protocol of the RED-CVD cluster randomised diagnostic trial". BMJ Open 11, n.º 10 (outubro de 2021): e046330. http://dx.doi.org/10.1136/bmjopen-2020-046330.
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IntroductionThe early stages of chronic progressive cardiovascular disease (CVD) generally cause non-specific symptoms that patients often do not spontaneously mention to their general practitioner, and are therefore easily missed. A proactive diagnostic strategy has the potential to uncover these frequently missed early stages, creating an opportunity for earlier intervention. This is of particular importance for chronic progressive CVDs with evidence-based therapies known to improve prognosis, such as ischaemic heart disease, atrial fibrillation and heart failure.Patients with type 2 diabetes or chronic obstructive pulmonary disease (COPD) are at particularly high risk of developing CVD. In the current study, we will demonstrate the feasibility and effectiveness of screening these high-risk patients with our early diagnosis strategy, using tools that are readily available in primary care, such as symptom questionnaires (to be filled out by the patients themselves), natriuretic peptide measurement and electrocardiography.Methods and analysisThe Reviving the Early Diagnosis-CVD trial is a multicentre, cluster randomised diagnostic trial performed in primary care practices across the Netherlands. We aim to include 1300 (2×650) patients who participate in a primary care disease management programme for COPD or type 2 diabetes. Practices will be randomised to the intervention arm (performing the early diagnosis strategy during the routine visits that are part of the disease management programmes) or the control arm (care as usual). The main outcome is the number of newly detected cases with CVDs in both arms, and the subsequent therapies they received. Secondary endpoints include quality of life, cost-effectiveness and the added diagnostic value of family and reproductive history questionnaires and three (novel) biomarkers (high-sensitive troponin-I, growth differentiation factor-15 and suppressor of tumourigenicity 2). Finally newly initiated treatments will be compared in both groups.Ethics and disseminationThe protocol was approved by the Medical Ethical Committee of the University Medical Center Utrecht, the Netherlands. Results are expected in 2022 and will be disseminated through international peer-reviewed publications.Trial registration numberNTR7360.
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Penner, Regina V. "Review of the Book by Rosi Braidotti “Posthuman”". Galactica Media: Journal of Media Studies 4, n.º 2 (27 de junho de 2022): 173–82. http://dx.doi.org/10.46539/gmd.v4i2.268.
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The article offers reflections on Rosi Braidotti’s book “Posthuman”, which was published in 2021 by the Gaidar Institute Publishing House (translator Diana Khamis). Rosi Braidotti is a contemporary philosopher and feminist theorist, originally from Italy, currently teaching at the Utrecht University (Netherlands). Despite her connection with significant international organizations and associations (including UNESCO, Conseil National de la Recherche Scientifique, France, European Consortium for Humanities Institutes and Centres, EEC) and the role that her research plays in contemporary social and humanitarian discourse, her name is not widely known to the Russian-speaking reader in comparison to other authors of feminist trend, such as Judith Butler or Donna Haraway. Rosi Braidotti’s interest is directed towards the reflections on the subjectivity of a contemporary person. Based on critical theory, the project of nomadology, feminist studies, and using her own anti-humanistic optics, she affirms the idea of a posthuman who has a developing identity, overcomes anthropocentric limits in its essence, and is open to assemblies with living matter and the world of technology. In this review, I focus on the main structural elements of the book, its key ideas; I offer my interpretation of some plots of the text; I dwell on the discussion points of the work. I come to the conclusion that the concept of the posthuman and the posthumanistic method allow us to open new horizons for the current research practices of man and society.
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Nahm, Michael. "A History of the (Attempted) Institutionalization of Parapsychology". Journal of Scientific Exploration 34, n.º 4 (24 de dezembro de 2020): 849–53. http://dx.doi.org/10.31275/20201953.
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In addition to an introduction, the present book contains 14 chapters. Most of them represent elaborated text versions of contributions that were presented by the authors at a (nearly) eponymous conference held in Freiburg, Germany, on the 17.10.2014. As the book title announces, the chapter authors trace the development of parapsychological research in different countries. Usually they focusing on the more or usually less successful attempts to academicize and institutionalize parapsychology as a legitimate scientific discipline, but sometimes they cover also related aspects. The chapters include historical parapsychological treatises for Germany (Ulrich Linse, Anna Lux, Uwe Schellinger, Martin Schneider, Bernd Wedemeyer-Kolwe) including the GDR (Andreas Anton, Ina Schmied-Knittel, Michael Schetsche), France (Renaud Evrard), Great Britain (Elizabeth Valentine), Hungary (Júlia Gyimesi), the Netherlands (Ingrid Kloosterman), Russia in the Soviet and post-Soviet area (Birgit Menzel), and the USA (Eberhard Bauer, Anna Lux). The four chapters covering France, Great Britain, Hungary, and the Netherlands are written in English, the others in German. In the following, will briefly touch upon topics I found most interesting.
Anna Lux from the university in Freiburg, Germany, identified several characteristic aspects of academic parapsychological work in Germany and compared them with those in the USA, which took place at about the same time and were more strongly focused on the experimental paradigm. She shows how different social circumstances and also private predilections of the main actors involved resulted in different developments. This also applies to the fate of parapsychology in the other countries mentioned, which is surprisingly multifaceted: While in the Netherlands the situation with official professorships at the University of Utrecht can be compared most closely to that of Germany where Hans Bender (1907-1991) held a professorship at the university of Freiburg, the academization of parapsychology in Hungary was hindered by an influential spiritualist and religious social current. In France, however, comparable efforts were mainly impeded by continued opposition of established scientists. After all, the private research institute “Institute Métapsychique International” (IMI) was founded in France in 1919, which has survived to this day despite adverse circumstances. Great Britain has always played a special role in Western parapsychology, mainly due to the foundation of the “Society for Psychical Research” as early as 1882, which is still considered an international figurehead for a constructive and critical examination of parapsychological topics. However, in Great Britain existed several other societies and “institutes”, which were often small and short-lived. It was not until 1985 that parapsychological research was able to gain a foothold at a British university for the first time through an endowed professorship in Edinburgh, held by Robert Morris (1942–2004) until 2004. From here, numerous graduates were able to carry the work on parapsychological research questions further to other universities.
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Oscar, William. "Reviewer Acknowledgements". International Journal of Contemporary Education 2, n.º 2 (25 de setembro de 2019): 148. http://dx.doi.org/10.11114/ijce.v2i2.4541.
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International Journal of Contemporary Education (IJCE) would like to acknowledge the following reviewers for their assistance with peer review of manuscripts for this issue. Many authors, regardless of whether IJCE publishes their work, appreciate the helpful feedback provided by the reviewers. Their comments and suggestions were of great help to the authors in improving the quality of their papers. Each of the reviewers listed below returned at least one review for this issue.Reviewers for Volume 2, Number 2Alexandra Ingram, University of Tennessee, USAÁlvaro Manzano Redondo, UCJC University, SpainAurora Q. Pestano, University of San Jose Recoletos, PhilippinesBlessing Dwumah Manu, Jiangsu University, GhanaDina Radeljas, Mohawk Valley Community College, USAFederica Cornali, University of Turin, ItalyFroilan Delute Mobo, Philippine Merchant Marine Academy, PhilippinesGiuseppe Maugeri, Ca' Foscari University, ItalyInaad M Sayer, University of Human Development, IraqIonel Bondoc, University of Agricultural Sciences and Veterinary Medicine Iasi, RomaniaIosif Fragkoulis, Hellenic Open University, GreeceJavier Fombona, Univ. Oviedo, SpainLi Li, Bath Spa University, UKMakrina Nina Zafiri, Aristotle University of Thessaloniki, GreeceMatthew Schatt, University of Florida, USAMs. Bruna Gabriela Augusto Marçal Vieira, Universidade Estadual Paulista, BrazilMurat Tezer, Near East University, CyprusNesrin Ozturk, Ege University, TurkeyNoelia Navarro Gómez, Universidad de Almería, SpainRaymond Aaron Younis, ACU Australia, AustraliaSaid K. Juma, State University of Zanzibar, TanzaniaSandro Sehic, Oneida BOCES, USASuriadi Samsuri, Institute of Islamic Religion Sultan Muhammad Syafiuddin Sambas, IndonesiaTeresa Pozo-Rico, University of Alicante, SpainVassiliki Pliogou, Metropolitan College of Thessaloniki, GreeceVassilios Papadimitriou, University of Thessaly, GreeceXiaojing Sun, Utrecht University, The Netherlands William OscarEditorial AssistantInternational Journal of Contemporary Education---------------------------------------------------------Redfame Publishing9450 SW Gemini Dr. #99416Beaverton, OR 97008, USATel: 1-503-828-0536 ext. 509Fax: 1-503-828-0537E-mail: ijce@redfame.comURL: http://ijce.redfame.com
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Hillebregt, Chantal F., Eline W. M. Scholten, Marjolijn Ketelaar, Marcel W. M. Post e Johanna M. A. Visser-Meily. "Effects of family group conferences among high-risk patients of chronic disability and their significant others: study protocol for a multicentre controlled trial". BMJ Open 8, n.º 3 (março de 2018): e018883. http://dx.doi.org/10.1136/bmjopen-2017-018883.
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IntroductionMany patients and family members experience a large gap between the protected environment during inpatient medical rehabilitation and life in the community after discharge. They feel insufficiently prepared to cope with the consequences of their disability in daily life. This study protocol describes the design measuring the effectiveness and implementation of family group conferences on the empowerment of patients with a high risk of chronic disability and their significant others.Methods and analysisA multicentre controlled trial will be carried out in 12 rehabilitation centres in the Netherlands. A total of 328 clinically admitted patients will participate (≥18 years, diagnosed with acquired brain injury, spinal cord injury or leg amputation), and their significant others will be included. During three family group conferences, supported by the social worker, the patient, significant other and their social network will be stimulated in collaboration, to set up participation goals, determine the needed help and make a concrete action plan. Self-reported questionnaires will be collected at baseline, clinical discharge, and 3 months and 6 months following clinical discharge. Empowerment as the primary outcome is operationalised as self-efficacy and participation. Secondary outcome measures are psychological (eg, coping, neuroticism) and environmental (eg, family functioning, social support) factors. This is the first controlled trial evaluating the effectiveness of family group conferences in rehabilitation medicine among adult patients and their significant others, providing us with knowledge in improving rehabilitation care.Ethics and disseminationThis study has been approved by the Medical Ethics Committee of the University Medical Center Utrecht (number 15–617/C). The results will be published in peer-reviewed journals and presented in local, national and international conferences.Trial registration numberNTR5742; Pre-results.
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Menne, Tobias, Daniel Slade, Joshua Savage, Sarah Johnson, Julie Irving, Pamela Kearns, Ruth Plummer et al. "Selumetinib in combination with dexamethasone for the treatment of relapsed/refractory RAS-pathway mutated paediatric and adult acute lymphoblastic leukaemia (SeluDex): study protocol for an international, parallel-group, dose-finding with expansion phase I/II trial". BMJ Open 12, n.º 3 (março de 2022): e059872. http://dx.doi.org/10.1136/bmjopen-2021-059872.
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IntroductionEvent-free survival rates at 15 years for paediatric patients with relapsed/refractory acute lymphoblastic leukaemia (ALL) are 30%–50%, with 5-year survival for adult patients only 20%. Many patients with newly diagnosed and relapsed ALL harbour somatic RAS-signalling activation mutations. Induction therapy for ALL involves steroids, with preclinical data suggesting the combination of dexamethasone with the MEK1/2 inhibitor, selumetinib (ARRY-142886) has a synergistic anticancer effect.Methods and analysisThe SeluDex trial is an international, parallel-group, dose-finding with expansion, phase I/II trial to assess the selumetinib/dexamethasone combination in adult and paediatric patients with relapsed/refractory, RAS pathway mutant ALL. The Cancer Research UK Clinical Trials Unit at University of Birmingham is the UK Coordinating Centre, with national hubs in Copenhagen, Denmark; Monza, Italy; Münster, Germany; Paris, France; and Utrecht, Netherlands. Patients with morphologically proven relapsed/refractory or progressive B-cell precursor or T-cell ALL, with demonstrated RAS pathway activating mutations are eligible. Adult patients are >18 years old, ECOG <2 and paediatric <18 years old, Lansky play scale ≥60% or Karnofsky score ≥60%. Phase I primary objective is the recommended phase II dose of selumetinib as defined by occurrence/non-occurrence of dose limiting toxicities using the continual reassessment method; phase II will evaluate preliminary antileukaemic activity of the combination, as defined by morphological response 28 days post-treatment using a Bayesian approach. Target recruitment is between 26 and 42 patients (minimum 13 and maximum 21 per group), depending the number of phase I patients included in phase II.Ethics and disseminationMedical ethical committees of all the participating countries have approved the study protocol; initial (UK) ethics approval (17/YH/0123) was granted by Yorkshire & The Humber—Leeds West Research Ethics Committee. Participants are required to provide written informed consent/assent. Results will be disseminated through national and international presentations and peer-reviewed publications.Trial registration numberISRCTN92323261.
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Sieradz, Małgorzata. "‘With deepest respect and gratitude…’. On the early years of Myroslaw Antonowycz’s musicological path, from his letters to Adolf Chybiński". Muzyka 67, n.º 2 (8 de julho de 2022): 113–60. http://dx.doi.org/10.36744/m.1296.
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Myroslaw Antonowycz (1917–2006) was a musicologist, conductor and composer, a Ukrainian whose entire career in musicology was associated with his work at Utrecht University. He is well known primarily among musicologists studying the music of Josquin des Prez, and more generally – of Franko-Flemish composers, as well as among Byzantinists. He was an alumnus of the Faculty of Musicology at Lviv’s (then Lwów’s) Jan Kazimierz University, where he studied for three years in the last period of Adolf Chybiński’s (1880–1952) academic work in Lviv. Chybiński was the founder and head of the chair, as well as one of the founding fathers of Polish musicology. The history of Lviv musicology and the representation of the Ukrainian minority in this milieu has already been studied by such Polish and Ukrainian musicologists as Ulyana Hrab, Vasyl Vitvitskyi, Luba Kijanowska, Leszek and Teresa Mazepa, Yuri Yasinovskyi, Michał Piekarski, and Małgorzata Sieradz. Since unfortunately most of their works have been published in either Polish or Ukrainian, that is, languages less common in international research, the present paper is an attempt to present the figure of this eminent scholar to a wider audience. This biographical sketch concerning Antonowycz’s early years as a musicologist was directly inspired by a set of forty-one letters and nine postcards sent by this researcher to Adolf Chybiński in 1939–52. This correspondence is now kept at the Poznań University Library, the Adolf Chybiński Archive at the Music Collections Studio, Special Collections Department, shelf mark 803 III/1, c. 4–58). These sources in this publication they have been printed in full and with commentary (see the Appendix). Their presentation is complementary to Yuri Yasinovskyi’s edition of Chybiński’s letters to Antonowycz (Musica Humana [Lviv] I 2003 pp. 67–110). Antonowycz spent World War II in Vienna, Linz, and Łódź, where he focused first and foremost on his singing skills (appearing in opera houses, on concert stages, and in radio broadcasts). He also continued his musicological studies at the University of Vienna. Having settled in the Netherlands after the war, he started work under Professor Albertus Smijers, founder and long-time head (from 1930 till his death in 1957) of the chair of musicology at De Universiteit Utrecht, who is universally recognised at the founder of the Dutch school of musicology. Having obtained his doctorate, he became Smijers’s assistant and co-editor of the Werken van Josquin des Prez, initiated and edited from 1922 by Smijers. After Smijers’s death Antonowycz undertook to complete work on the successive volumes in this series, first on his own and later with Willem Elders. In this way he made a name for himself in history of the world musicology. The surviving letters by Myroslaw Antynowycz offer direct proof of his strong attachment to the Lviv university circles and his first mentor, Professor Adolf Chybiński. Though Antynowycz was associated from the late 1940s and throughout his professional career with Utrecht University, where he obtained his PhD, it needs to be emphatically stated that his scholarly attitude had been shaped during his studies at the Faculty of Musicology of Lviv’s Jan Kazimierz University, and he frequently declared that Chybiński, a founding father of the Polish musicology and its Lviv centre, was his model as a scholar.
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Kozlov, Yu A., K. A. Kovalkov, V. M. Kapuller, S. Rothenberg, A. Yu Razumovsky, D. van der Zee, D. Patkowski e A. N. Narkevich. "THORACOSCOPIC TREATMENT OF ESOPHAGEAL ATRESIA: 18-YEARS INTERNATIONAL EXPERIENCE IN 775 PATIENTS IN FIVE CHILDREN’S SURGERY CENTERS". Pediatria. Journal named after G.N. Speransky 100, n.º 3 (28 de maio de 2021): 240–47. http://dx.doi.org/10.24110/0031-403x-2021-100-3-240-247.
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The paper presents a synthesis of the multicenter retrospective comparative study of the treatment of patients with esophageal atresia (EA) from 5 children's hospitals located in different countries of the world. Materials and methods of research: The study examined the results of surgical treatment of 775 patients with EA who were treated in 5 children’s hospitals located in Russia, USA and Europe: Ivano-Matreninskaya Children's Clinical Hospital, Irkutsk (Russia) – 126 patients; Children's Hospital of the Rocky Mountains, Denver (Colorado, USA) – 143, Pirogov Russian National Research Medical University, Moscow (Russia) – 175, University Medical Center, Utrecht (Netherlands) – 173, University of Medicine, Wroclaw (Poland) – 158 patients. The study lasted 18 years, from the very beginning of technology adoption in these hospitals and endied in December 2018 (from 2000 to 2018). In relation to patients, uniform technological methods of performing thoracoscopic anastomosis of the esophagus and recommendations for the postoperative management of such patients were applied, issued and controlled by all participants in this process. Results: in the analysis of treatment outcomes, mortality associated with surgery and mortality that had no causal link with surgery were considered. Mortality associated with surgical intervention in the presented treatment series did not differ statistically significantly and amounted to 0,8% (minimum – 0,0%, maximum – 1,7%, p=0,320). Non-operation fatalities varied statistically significantly and ranged from 0,0% to 4,4% (weighted average – 3,0%, p=0,030), but a pairwise comparison with the Benjamini-Hochberg amendment shows no statistically significant differences between the cities of the study. Anastomotic leakage (failure) rate was comparable and was detected in 5,8% of cases (minimum 2,9%, maximum 9,7%, p=0,059). Statistically significant differences were found in the following parameters: anastomotic stenosis developed in 10,3–39,9% of cases (weighted average – 20,1%, p<0,001); fistula recanalization was recorded in 2,7% of patients (minimum – 0,7%, maximum – 8,1%, p<0,001); the need for fundoplication existed in 14,3% of patients (minimum – 2,5%, maximum – 26,0%, p<0,001); the level of detection of tracheomalacia also differed in the presented treatment series and ranged from 0,0% to 9,2% (weighted average – 3,7%, p<0,001). Thus, the use of thoracoscopy for the treatment of EA ensures a low level of postoperative mortality, a low incidence of early and late postoperative complications. Conclusion: thoracoscopic EA reconstruction can be safely performed by experienced endoscopic surgeons from different centers, united by one technology for performing endosurgical operations in newborns and infants.
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Donners, Anouk, Konrad van der Zwet, Antoine C. G. Egberts, Karin Fijnvandraat, Ron Mathôt, Ilmar Kruis, Marjon H. Cnossen, Roger Schutgens, Rolf T. Urbanus e Kathelijn Fischer. "DosEmi study protocol: a phase IV, multicentre, open-label, crossover study to evaluate non-inferiority of pharmacokinetic-guided reduced dosing compared with conventional dosing of emicizumab in people with haemophilia A". BMJ Open 13, n.º 6 (junho de 2023): e072363. http://dx.doi.org/10.1136/bmjopen-2023-072363.
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IntroductionEmicizumab effectively prevents bleeding in people with haemophilia A (PwHA), but is a burden for national healthcare budgets and consequently may limit access. According to the drug label, dosing of emicizumab is based on body weight with fixed intervals of 7, 14 or 28 days, which leads to mean plasma concentrations of 55 µg/mL (SD 15 µg/mL). However, a moderate variability of concentrations and a minimal effective concentration of 30 µg/mL have been suggested in studies. Therefore, a dose of emicizumab that targets a trough concentration of 30 µg/mL is hypothesised to be equally effective as conventional dosing in the prevention of bleeding.Methods and analysisWe designed a phase IV, multicentre, open-label, crossover study to evaluate non-inferiority of bleed control of ≥6 months on conventional dosing in comparison to ≥6 months on dose intervention. This dose intervention consists of reducing the dose of emicizumab to target a trough concentrations of 30 µg/mL using individual pharmacokinetic (PK) parameters. Ninety-five PwHA aged >1 years who received conventional dosing of emicizumab for ≥12 months with good bleeding control during the last 6 months will be recruited from all Dutch haemophilia treatment centres. The study is powered to detect a clinically relevant decrease (risk difference) of 15% in the proportion of patients without treated bleeds during follow-up. Secondary endpoints are spontaneous joint or muscle bleeds, and annualised treated bleeding rates (using negative binomial regression). Cost-effectivity between conventional dosing and individualised PK-guided dosing of emicizumab will be compared.Ethics and disseminationThe DosEmi study was approved by the Medical Ethics Review Committee NedMec of the University Medical Center of Utrecht, The Netherlands. Study results will be communicated through publications in international scientific journals and presentations at (inter)national conferences.Trial registration numberEUCTR2021-004039-10-NL athttps://trialsearch.who.int.Protocol versionV.4.1 on 28 October 2022 (DosEmi protocol_V4.1; NL81112.041.22).
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Diepstraten, Franciscus A., Annelot JM Meijer, Martine van Grotel, Sabine LA Plasschaert, Alexander E. Hoetink, Marta Fiocco, Geert O. Janssens, Robert J. Stokroos e Marry M. van den Heuvel-Eibrink. "A Study on Prevalence and Determinants of Ototoxicity During Treatment of Childhood Cancer (SOUND): Protocol for a Prospective Study". JMIR Research Protocols 11, n.º 4 (7 de abril de 2022): e34297. http://dx.doi.org/10.2196/34297.
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Background Some children with central nervous system (CNS) and solid tumors are at risk to develop ototoxicity during treatment. Up to now, several risk factors have been identified that may contribute to ototoxicity, such as platinum derivates, cranial irradiation, and brain surgery. Comedication, like antibiotics and diuretics, is known to enhance ototoxicity, but their independent influence has not been investigated in childhood cancer patients. Recommendations for hearing loss screening are missing or vary highly across treatment protocols. Additionally, adherence to existing screening guidelines is not always optimal. Currently, knowledge is lacking on the prevalence of ototoxicity. Objective The aim of the Study on Prevalence and Determinants of Ototoxicity During Treatment of Childhood Cancer (SOUND) is to determine the feasibility of audiological testing and to determine the prevalence and determinants of ototoxicity during treatment for childhood cancer in a national cohort of patients with solid and CNS tumors. Methods The SOUND study is a prospective cohort study in the national childhood cancer center in the Netherlands. The study aims to include all children aged 0 to 19 years with a newly diagnosed CNS or solid tumor. Part of these patients will get audiological examination as part of their standard of care (stratum 1). Patients in which audiological examination is not the standard of care will be invited for inclusion in stratum 2. Age-dependent audiological assessments will be pursued before the start of treatment and within 3 months after the end of treatment. Apart from hearing loss, we will investigate the feasibility to screen patients for tinnitus and vertigo prevalence after cancer treatment. This study will also determine the independent contribution of antibiotics and diuretics on ototoxicity. Results This study was approved by the Medical Research Ethics Committee Utrecht (Identifier 20-417/M). Currently, we are in the process of recruitment for this study. Conclusions The SOUND study will raise awareness about the presence of ototoxicity during the treatment of children with CNS or solid tumors. It will give insight into the prevalence and independent clinical and cotreatment-related determinants of ototoxicity. This is important for the identification of future high-risk patients. Thereby, the study will provide a basis for the selection of patients who will benefit from innovative otoprotective intervention trials during childhood cancer treatment that are currently being prepared. Trial Registration Netherlands Trial Register NL8881; https://www.trialregister.nl/trial/8881 International Registered Report Identifier (IRRID) DERR1-10.2196/34297