Artigos de revistas sobre o tema "Approche par LMI"

To characterize the spatial heterogeneity of forest canopies at various scales, leaf area index (LAI) and transmission of photosynthetically active radiation (PAR) were measured. Six Scots pine (Pinussylvestris L.) stands, representing typical growth stages, from regeneration to mature forest, were selected for study, in Alsace, France. In each stand, hemispherical photographs were taken near the ground at regular intervals along transects, digitized, and analyzed. Gap fractions were inverted to provide estimates of LAI. Light transmission through the canopy was calculated by means of a numerical method. In a typical mature stand, the variability of LAI and PAR transmittance was spatially assessed by means of semi-variograms; spatial autocorrelation occurred up to about 10 m. This result provided a guide to optimize the sampling at the forest mosaic level. For the whole forest, LAI ranged from 1.6 to 7.8; PAR transmittance ranged from 0.02 to 0.59 under overcast sky and from 0.01 to 0.48 under clear sky (June). Maximum variability was found in the youngest stand, owing to a row effect, and in the two oldest stands, which include Norway spruce (Piceaabies (L.) Karst.) patches in the understory. Intermediate variability characterized maturing stands. Methodological problems concerning LAI and PAR transmission estimated by indirect approaches are discussed, as well as the spatial structure of these variables.

K. Zalcmane in her publication has reflected the problem of the new security principles of soccer in Europe. The author analyses the significance of the European Parliament Convention on integrated approach to security, guard and servicing during the game of soccer and other sporting games. The regulations of the new convention are dedicated to integration of the wholistic approach on questions regarding security during the sporting events. The article mentions new approaches to ensure security during the sporting events. K. Zalcmane savā publikācijā ir atspoguļojusi problēmu par jaunajiem futbola drošības principiem Eiropā. Autore analizē Eiropas Padomes Konvencijas par integrētu pieeju drošības, apsardzes un apkalpošanas futbola spēļu un citu sporta pasākumu laikā jautājumiem nozīmi. Rakstā konstatēts, ka jaunās Konvencijas noteikumi ir paredzēti, lai integrētu vispārīgu pieeju drošības jautājumiem sporta pasākumu laikā, un minētas jaunas pieejas sporta pasākumu drošības nodrošināšanā.

In this paper, the state-feedback mixed H2/H∞ control problem for state-delayed linear systems is considered. Sufficient conditions for the solvability of this problem are given in terms of the solution to a pair of algebraic Riccati equations similar to the nondelayed case. However, these Riccati equations are more difficult to solve than those arising in the pure H2,H∞ problems, and an alternative approach is to solve a pair of linear matrix inequalities (LMIs).

AbstractElectrical properties of a set of lithium-ion conducting sulfide glasses with general formula 20LiI-xGa2S3-(80-x)GeS2 (x = 10, 15 and 20) is studied in the present article. The experimental data obtained using impedance spectroscopy are analyzed by means of a random-walk (RW) model assuming that the conduction takes place by a random motion of Li+ ions. The influences of added gallium on the structural network and on the conductivity of prepared glasses are also analyzed using the RW model. The results are further confirmed by Raman spectral analysis. The results obtained by the random-walk model and by a conventional equivalent electric circuit model are in a good agreement. We observed that the addition of Ga2S3 contributed to phase separation in the prepared glassy system and negatively influenced the conductivity of the studied glasses. Factors contributing to the total conductivity with respect to the amount of both LiI and Ga2S3 are also reported.

A simulation model was built as a decision aid for management of five weed species in direct seeded irrigated onion (Allium cepa L.). The model uses the state variable approach and simulations are driven by temperature and sunlight as photosynthetically active radiation (PAR). It predicts yield reduction caused by competition for PAR according to the ratio of crop leaf area index (LAI) to weed LAI and respective light extinction coefficients (k). Input variables are plant density by species and average number of leaves by species. Number of leaves per plant is used by the model to provide an estimate of initial leaf area per plant. The model calculates initial species LAIs by multiplying species density times average leaf area per plant. The model accurately describes competitive interactions, taking into account respective plant densities, time of emergence, and time of weed removal. It permits economic evaluation of management factors such as handweeding, chemical weed control, herbicide phytotoxicity due to early application, and control of weed flushes during the season. The model is also used to evaluate mechanisms of plant competition for sunlight. In a sensitivity analysis, onion yield loss was more sensitive to weed PAR interception than to PAR use efficiency, the latter a species-dependent constant in the model.

Two-dimensional images of OH fluorescence, polycyclic aromatic hydrocarbons (PAHs) fluorescence, and laser-induced incandescence (LII) from soot were measured in a sooting diffusion flame. To obtain an accurate OH fluorescence image, two images were taken with the laser wavelength tuned to (“on”) and away from (“off”) the OH absorption line. An accurate OH fluorescence image was obtained by subtracting the off-resonance image from the on-resonance image. For the PAH fluorescence and LII measurements, temporally resolved measurements were used to obtain the individual images; the LII image was obtained by detecting the LII signal after the PAH fluorescence radiation had stopped and the PAH fluorescence image was obtained by subtracting the LII image from the simultaneous image of PAH fluorescence and LII. Based on the obtained images, the relative location of OH, PAH, and soot in the flame was discussed in detail. To investigate the PAH size distribution in a sooting flame using LIF, an estimation strategy for PAH size is proposed. Emission spectra were measured at several heights in the flame using a spectrograph. Since the emission wavelength of PAH fluorescence shifts toward longer wavelengths with increasing PAH size, the main PAH components in the emission spectra could be estimated. The results suggest that PAH grows and the type of PAH changes as the soot inception region was approached. Near the soot inception region, we estimated that the PAHs, which have over 16 carbon atoms, mainly constituted the emission spectrum.

Abstract. Volcanic eruptions can alter the quality of incoming solar irradiance reaching the Earth's surface thereby influencing the interactions between vegetation and the Earth system. Isoprene (C5H8) is a biogenic volatile organic compound emitted from leaves at a rate that is strongly dependent on the received flux of photosynthetically active radiation (PAR). We used a theoretical approach to investigate the potential for volcanic eruptions to change the isoprene flux from terrestrial forests using canopy-scale isoprene emission simulations that vary either the relative or absolute amount of diffuse (Idiff) and direct (Idir) PAR. According to our simulations for a northern hardwood deciduous forest, if the total amount of PAR during summer remains constant while the proportion of Idiff increases, canopy-scale isoprene emissions increase. This effect increases as leaf area index (LAI) increases. Simulating a decrease in the total amount of PAR, and a corresponding increase in Idiff fraction, as measured during the 1992 Pinatubo eruption, changes daily total canopy-scale isoprene emissions from terrestrial vegetation in summertime by +2.8% and −1.4% for LAI of 6 and 2, respectively. These effects have not previously been realized or quantified. Better capturing the effects of volcanic eruptions (and other major perturbations to the atmospheric aerosol content) on isoprene emissions from the terrestrial biosphere, and hence on the chemistry of the atmosphere, therefore may require inclusion of the effects of aerosols they produce on climate and the quality of PAR.

Abstract. Accurate measurement of vegetation density metrics including plant, wood and leaf area indices (PAI, WAI and LAI) is key to monitoring and modelling carbon storage and uptake in forests. Traditional passive sensor approaches, such as digital hemispherical photography (DHP), cannot separate leaf and wood material, nor individual trees, and require many assumptions in processing. Terrestrial laser scanning (TLS) data offer new opportunities to improve understanding of tree and canopy structure. Multiple methods have been developed to derive PAI and LAI from TLS data, but there is little consensus on the best approach, nor are methods benchmarked as standard. Using TLS data collected in 33 plots containing 2472 trees of 5 species in Mediterranean forests, we compare three TLS methods (lidar pulse, 2D intensity image and voxel-based) to derive PAI and compare with co-located DHP. We then separate leaf and wood in individual tree point clouds to calculate the ratio of wood to total plant area (α), a metric to correct for non-photosynthetic material in LAI estimates. We use individual tree TLS point clouds to estimate how α varies with species, tree height and stand density. We find the lidar pulse method agrees most closely with DHP, but it is limited to single-scan data, so it cannot determine individual tree properties, including α. The voxel-based method shows promise for ecological studies as it can be applied to individual tree point clouds. Using the voxel-based method, we show that species explain some variation in α; however, height and plot density were better predictors. Our findings highlight the value of TLS data to improve fundamental understanding of tree form and function as well as the importance of rigorous testing of TLS data processing methods at a time when new approaches are being rapidly developed. New algorithms need to be compared against traditional methods and existing algorithms, using common reference data. Whilst promising, our results show that metrics derived from TLS data are not yet reliably calibrated and validated to the extent they are ready to replace traditional approaches for large-scale monitoring of PAI and LAI.

RESUME Bien que le terme 'sociolinguistics' n'ait ete introduit dans le vocabulai-re technique de la linguistique qu'en 1952 par Haver Currie et que la socio-linguistique ne soit devenue une sous-discipline importante de la science du langage que depuis les annees soixante (v. Bright 1966), cet article main-tient qu'une telle approche du langage existait depuis longtemps, peut-etre plus de cent ans. En d'autres mots, nous avangons qu'il y avait une sociolin-guistique bien avant la lettre. En effet, on retrouve dans la linguistique generate de Wiliam Dwight Whitney (1827-1894) et de Heymann Steinthal (1823-1899) et dans quel-ques articles de Michel Breal (1832-1915) des annees 60 et 70 du siecle dernier des observations qui mettent en relief la nature sociale du langage. Les dialectologues de la meme periode, surtout en France et dans les pays de langue allemande, etaient tout a fait conscients du fait que l'etude des patois, des parlers et des langues orales en general devait etre guidee par des considerations sociologiques (v. Malkiel 1976). Dans la linguistique compa-ree et historique c'est Antoine Meillet (1866-1936), eleve de Saussure et de Breal et collaborates de la revue d'Emile Durkheim, Vannee sociologique, au debut de notre siecle, qui a insiste sur l'importance de l'aspect social (et sociologique) dans l'etude du changement linguistique (par ex., Meillet 1905). Avec ses eleves de Paris, surtout Joseph Vendryes (1875-1960), Alf Sommerfelt (1892-1965) et Marcel Cohen (1884-1974), Meillet etablit l'ecole sociologique du langage (par ex., Vendryes 1921; Sommerfelt 1932; Cohen 1956). Enfin, il existe — a cote de la dialectologie et de l'histoire des langues — encore une troisieme source de la sociolinguistique: l'etude du bilinguisme (par ex., Max Weinreich 1931; Haugen 1953). Ces trois traditions de la recherche linguistique se trouvent toutes reunis dans l'etude de Uriel Weinreich (1926-1967), Languages in Contact (1953), et puisque l'ouvrage de William Labov de 1966, The Social Stratification of English in New York City, qui est souvent cite (bien a tort) comme point de depart de la sociolo-gie moderne, representait sa these de doctorate ecrite sous la direction de Weinreich, il n'est pas etonnant de voir ces traditions, surtout celles de la linguistique geographique et de la linguistique historique, maintenues dans l'oeuvre de Labov (par ex., 1976, 1982). SUMMARY Although the term 'sociolinguistics' was not introduced into linguistic nomenclature before 1952 (see Currie 1952) and the field became a recognized field of research in the late 1960s only (e.g., Bright 1966), it is clear that the subject did not begin two decades ago. Indeed, an investigation into the sources of 'sociolinguistics' reveals that its beginnings go back at least 100 years, to the work of William Dwight Whitney (1827-1894), Heymann Steinthal (1823-1899), Michel Breal (1832-1915), and others. However, these were the first programmatic statements and a number of developments in the study of language were necessary to converge upon the kind of sociolinguistics which most students of language associate with the name of William Labov (e.g., Labov 1966), at least in North America. Interestingly enough, it is also in the work of Labov (e.g., 1972) that the origins of 'sociolinguistics' (to some extent in contradistinction to the 'sociology of language' approach associated with Basil Bernstein, Joshua A. Fishman, and others) could be traced, although neither Labov nor the prolific Dell Hymes has written anything on the history of sociolinguistics. (Indeed, the only paper that comes close to it was written by an outsider to the field, the great Romance scholar Yakov Malkiel, in 1976.) In my paper, I shall demonstrate that there are essentially three major traditions of investigation that led to 'sociolinguistics', namely, (1) Dialectology, especially the work done in German-speaking lands and in France from the 1870s onwards (e.g., Georg Wenker [1852-1911], Jules Gillieron [1854-1926], and others) — part of which had been undertaken in an effort to verify and possibility to support the neogrammarian 'regularity hypothesis' of sound changes; (2) Historical Linguistics, in particular the kind advocated by Antoine Meillet (1866-1936) and his school (e.g., Meillet 1905; Vendryes 1921), which developed into a 'science sociologique' of linguistics in general (Sommerfelt 1932) and a 'sociologie du langage' (e.g., Cohen 1956) among the younger Meillet disciples, and (3) Bilingualism Studies (e.g., Max Weinreich 1931; Haugen 1953), traditions all of which can be found united in the 1953 study of Uriel Weinreich (1926-1967), who happens to have been Labov's teacher and mentor.

Résumé L’article montre que la construction parenthétique ce m’est avis fonctionne comme un marqueur discursif dans un corpus outillé inédit de romans français en prose du 13e siècle. Nous adoptons une double approche, phraséologique et stylistique, pour étudier le fonctionnement discursif de ce marqueur dans les séquences représentant de l’oral (dialogue des personnages ou paroles du narrateur). La comparaison avec la construction en que P (il/ce) m’est avis que permet de noter leur origine commune puis leur spécialisation progressive dans la langue. Enfin, un aperçu de l’évolution diachronique du marqueur discursif ce m’est avis permet de constater son déclin et son remplacement par à mon avis.

Solutions for theH∞synthesis problems of asynchronous hybrid systems with input-output delays are proposed. The continuous-time lifting approach of sampled-data systems is extended to a hybrid system with multiple delays, and some feasible formulas to calculate the operators of the equivalent discrete-time (DT) system are given. Different from the existing methods derived from symplectic pair theory or by state augmentation, a Lyapunov-Krasovskii functional to solve the synthesis problem is explicitly constructed. The delay-dependent stability conditions we obtained can be described in terms of nonstrict linear matrix inequalities (LMIs), which are much more convenient to be solved by LMI tools.

Résumé Nous proposons dans cet article une analyse multifactorielle et contrastive de la notion de saillance, telle qu’elle s’applique aux entités du discours et détermine l’interprétation référentielle d’une anaphore. En observant les phénomènes de saillance en français et en chinois, notre but est de montrer que la saillance est influencée par une multitude de facteurs, de manière plus ou moins comparable dans les deux langues. Nous classons ces facteurs selon leur nature syntaxique, sémantique, textuelle ou pragmatique. Notre approche contrastive permet d’illustrer que, si plusieurs divergences – qui sont souvent corrélées avec les différences typologiques des deux langues – s’observent au niveau syntaxique, de nombreux facteurs de saillance dérivent plutôt de principes cognitifs généraux.

AbstractThe article describes a comprehensive mass spectrometric approach to the study of surfaces of structural materials. The combined use of thermal desorption mass spectrometry, gas and liquid chromatography, and laser desorption/ionization mass spectrometry (LDI) to provide information about the surface and surface layers of materials is proposed. The suggested method allows one to determine the thermodynamic characteristics of compounds and surface contaminants adsorbed on surfaces, as well as surface layers, to determine the composition of volatile and non-volatile contaminants on the surface, and to determine the nature of the distribution over the surface of these compounds. The method allows to obtain the most complete information about the surface condition and can be used to predict the life of structural materials.

The rule of law era has given rise to multiple indicators purporting to measure the concept. This article compares four major indicators of the rule of law and shows that their approaches to conceptualization and measurement differ. Given their disparate conceptualizations and measurement strategies, one might expect a weak correlation between them. Strikingly, however, all four indicators are highly correlated with each other (with the pair-wise correlations between three of them exceeding 0.95). They are also correlated with the widely used measure of corruption. This suggests that the indicators might capture a more encompassing concept, like impartial administration. The article critiques the rule of law measurement enterprise as insufficiently linked to the underlying normative concept. It points to the reliance on expert perceptions and information constraints as a possible cause for the convergence. It concludes that measurement strategy, rather than differences in conceptualization, explains the convergence between the indicators.

The application of organic liquid fertilizer combined with chemical fertilizer is one of the key technologies used to simultaneously improve cotton yield and efficiently utilize resources. However, organic fertilizer is usually applied once as a base fertilizer during production, and few studies have been conducted on topdressing with water during the growth period. Therefore, in this study, Xinluzao 74 was used as the experimental material, and a single fertilizer application (CF) was used as a control in 2019–2020 under the conditions of integrated control of water and fertilizer with mulch drip irrigation. Five combinations of reduction in chemical fertilizer combined with organic fertilizer (OF1, OF2, OF3, OF4, and OF5) were used to investigate the influences of chemical fertilizer combined with organic liquid fertilizer on the leaf area index (LAI), canopy openness (DIFN), mean foliage tilt angle (MTA), photosynthetically active radiation (PAR), canopy apparent photosynthesis (CAP), and yield and quality of cotton. The results show that among the different fertilization treatments, the OF2 treatment had the best results, not only ensuring a suitable LAI (4.8) and maintaining a large DIFN (0.1) but also increasing the light transmittance of the middle and lower canopies (0.02–0.03). At the same time, CAP increased significantly compared with that in the CF treatment, with an average increase of 12.8%. The high value lasted for a long time, and the late decay stage remained at 8.9 μmol m−2 s−1. The ratio of the population respiration rate to total photosynthesis (CR/TCAP) decreased significantly, with an average decrease of 13.5%. Compared with that in CF, the lint yield increased by 27.0% in the other treatments. The correlation analysis showed that lint yield was positively correlated with the relative chlorophyll content (SPAD value), PAR transmittance (PARU) and CAP in the upper canopy (p < 0.05) and significantly negatively correlated with PAR transmittance (PARM) in the middle canopy and PAR transmittance (PARD) and CR/TCAP in the lower canopy (p < 0.05). Therefore, under mulch drip irrigation, the OF2 treatment (OF + 80% CF) improved the canopy structure of cotton at the late growth stage, increased the population photosynthetic rate, and increased lint yield significantly; thus, this approach can be used as an effective fertilization method to achieve the goal of decreasing costs and increasing efficiency in cotton production.

This paper deals with the Maximum Power Point Tracking (MPPT) for photovoltaic energy system. It includes photovoltaic array panel, DC/DC converter, and load. The operating point for photovoltaic energy system depends on climatic parameters and load. For each temperature and irradiation pair, there exists only one optimal operating point which corresponds to the maximum power transmitted to the load. The photovoltaic energy system is described by nonlinear equations. It is transformed into an augmented system which is described with a Takagi-Sugeno (T-S) fuzzy model. The proposed MPPT algorithm which permits transfering the maximum power from the panel to the load is based on Parallel Distributed Compensation method (PDC). The control parameters have been computed based on Linear Matrix Inequalities tools (LMI). The Lyapunov approach has been used to prove the stability of the system. Some reliable simulation results are provided to check the efficiency of the proposed algorithm.

Estimating transpiration as an individual component of canopy evapotranspiration using a theoretical approach is extremely useful as it eliminates the complexity involved in partitioning evapotranspiration. A model to predict transpiration based on radiation intercepted at various levels of canopy leaf area index (LAI) was developed in a controlled environment using a pasture species, tall fescue (Festuca arundinacea var. Demeter). The canopy was assumed to be a composite of two indistinct layers defined as sunlit and shaded; the proportion of which was calculated by utilizing a weighted model (W model). The radiation energy utilized by each layer was calculated from the PAR at the top of the canopy and the fraction of absorbed photosynthetically active radiation (fAPAR) corresponding to the LAI of the sunlit and shaded layers. A relationship between LAI and fAPAR was also established for this specific canopy to aid the calculation of energy interception. Canopy conductance was estimated from scaling up of stomatal conductance measured at the individual leaf level. Other environmental factors that drive transpiration were monitored accordingly for each individual layer. The Penman–Monteith and Jarvis evapotranspiration models were used as the basis to construct a modified transpiration model suitable for controlled environment conditions. Specially, constructed self-watering tubs were used to measure actual transpiration to validate the model output. The model provided good agreement of measured transpiration (actual transpiration = 0.96 × calculated transpiration, R2 = 0.98; p < 0.001) with the predicted values. This was particularly so at lower LAIs. Probable reasons for the discrepancy at higher LAI are explained. Both the predicted and experimental transpiration varied from 0.21 to 0.56 mm h−1 for the range of available LAIs. The physical proportion of the shaded layer exceeded that of the sunlit layer near LAI of 3.0, however, the contribution of the sunlit layer to the total transpiration remains higher throughout the entire growing season.

Plant nitrogen (N) information has widely been estimated through empirical techniques using hyperspectral data. However, the physical model inversion approach on N spectral response has seldom developed and remains a challenge. In this study, an N-PROSAIL model based on the N-based PROSPECT model and the SAIL model canopy model was constructed and used for retrieving crop N status both at leaf and canopy scales. The results show that the third parameter (3rd-par) retrieving strategy (leaf area index (LAI) and leaf N density (LND) optimized where other parameters in the N-PROSAIL model are set at different values at each growth stage) exhibited the highest accuracy for LAI and LND estimation, which resulted in R2 and RMSE values of 0.80 and 0.69, and 0.46 and 21.18 µg·cm−2, respectively. It also showed good results with R2 and RMSE values of 0.75 and 0.38% for leaf N concentration (LNC) and 0.82 and 0.95 g·m−2 for canopy N density (CND), respectively. The N-PROSAIL model retrieving method performed better than the vegetation index regression model (LNC: RMSE = 0.48 − 0.64%; CND: RMSE = 1.26 − 1.78 g·m−2). This study indicates the potential of using the N-PROSAIL model for crop N diagnosis on leaf and canopy scales in wheat.

L’espace blanc, envisagé ici comme une surface vide, souvent ignoré, est pourtant un élément essentiel de la structuration et de la mise en texte, en page et en livre à l’époque médiévale. Trois exemples, de la plus petite à la plus grande surface concernée, permettent ici de l’envisager, en présentant des champs de réflexion à développer. Ainsi le blanc entre les mots, réévalué par les linguistes avec notamment les travaux de Nelly Andrieux-Reix et Simone Monsonego, est aujourd’hui considéré comme un outil pour appréhender la conscience linguistique des copistes ; il pourrait ainsi permettre de nouvelles approches dans les manuscrits écrits dans des zones de contact linguistique, comme les manuscrits copiés en Italie. Le trou dans le support manuscrit peut quant à lui être utilisé dans des mises en scène esthétiques et graphiques complexes, qui font écho et dialoguent avec le texte copié autour de lui, comme on le voit dans le Roi Flore et la belle Jeanne, lors de la scène du bain interrompu par Raoul (Paris, BnF, fr. 24430). Enfin, l’utilisation d’espaces blancs et la distribution et l’agencement des éléments sur la page (module des écritures, rubriques, place des illustrations, présence ou non de bouts-de-lignes) dans le Double Lai de fragilité humaine du BnF, fr. 20029 permet à Eustache Deschamps d’infléchir l’un des dispositifs de mise en page utilisés pour les traductions. Il inverse ainsi en partie le statut attendu dans ces mises en page pour les deux textes mis en regard.

In this article, the application of the FRAME (Frequency Recognition Algorithm for Multiple Exposures) technique is presented for multi-species measurements in symmetric and asymmetric ethylene/air diffusion flames. Laminar Bunsen-type and swirled diffusion flames are investigated to gain a better understanding of sooting combustion. For this purpose, simultaneous imaging is conducted in terms of Laser-Induced Fluorescence (LIF) of Polycyclic Aromatic Hydrocarbons (PAH) and Laser-Induced Incandescence (LII) of soot particles. Subsequently, the approach is utilized for simultaneous imaging of hydroxyl (OH)-LIF and soot-LII. Here, the modulated LIF- and LII-signals are acquired together as a single sub-image—with a single exposure utilizing the full sensor size of a single camera. By employing the frequency-recognition algorithm on the single image, the LIF- and LII-signals are spectrally isolated—generating two individual LIF- and LII-images. The flame luminosity and out-of-focus light such as reflected surrounding laser light are detected as non-modulated signals in the unprocessed image. These unwanted signals are suppressed using the image post-processing, and, therefore, the image contrast of the two resulting images is improved. It is found that PAHs mainly exist in the inner region near the burner and are surrounded by soot. The majority of the OH is distributed on the outer edges of the flame—representing the reaction zone and soot-oxidation region of the flame.

Perceforest est un vaste roman en prose que Christine Ferlampin-Acher propose de dater, non du xive siècle, mais du xve. C’est sur cette datation qu’est basée l’étude qui suit. S’interroger sur le pastiche dans une oeuvre médiévale est tributaire d’une approche stylistique, problématique. À l’inverse, le questionnement sur le pastiche peut contribuer à nourrir une réflexion sur le style dans les oeuvres médiévales. Perceforest se présente comme une suite, à la fois de l’Historia Regum Britaniae et des Voeux du Paon, et comme une préhistoire du Graal du cycle de la Vulgate : y a-t-il continuité stylistique (et donc pastiche) entre Perceforest et les textes qui le bornent, en amont et en aval ? Le sujet, vaste, est abordé à travers l’étude du maintien de déclinaisons à morphologie latine (sera étudiée la relation entre Perceforest et ses modèles en amont) et de deux discours, du Christ et d’Alain (sera ciblée la relation avec le cycle Vulgate). Par ailleurs, Perceforest, comme chronique fictive, présente des traits qui vieillissent le texte et qui pourraient ressortir du pastiche : cependant, la patine naît surtout d’une nouvelle conception du passé, nostalgique, du fait de la confrontation avec le présent. L’étude du Conte de la Rose, dont la version en vers peut se lire comme un pastiche de lai et la version en prose comme un pastiche de mise en prose, confirme que c’est par la prise en charge du présent (les mises en prose sont un genre « moderne ») que l’écart temporel avec le passé se trouve le mieux mis en perspective. Finalement, comme les entremets et l’entrelardement (ce terme désigne dans Perceforest une conception esthétique fondée sur la variété), le pastiche a pour enjeu essentiel de redonner du goût à ce qui risque de devenir plat, monotone, routinier, topique.

Snapshot multispectral imaging of chemical species in the flame is essential for improved understanding of the combustion process. In this article, we investigate the different configurations of a structured laser sheet-based multispectral imaging approach called the Frequency Recognition Algorithm for Multiple Exposures (FRAME). Using FRAME, a snapshot of Laser-Induced Fluorescence (LIF) of Polycyclic Aromatic Hydrocarbons (PAH) excited by 283.5 nm laser and Laser-Induced Incandescence (LII) of soot particles excited by 532 nm laser are acquired simultaneously on a single FRAME image. A laminar diffusion flame of acetylene produced by a Gülder burner is used for the experiments. The standard FRAME approach is based on creating two spatially modulated laser sheets and arranging them in a cross-patterned configuration (X). However, the effect of using different configurations (angles) of the two laser sheets on the multispectral planar imaging of the flame has not yet been studied. Therefore, we have compared the FRAME approach in four different configurations while keeping the same flame conditions. First, we have compared the relation between laser fluence and LII signals with and without spatial modulation of the 532 nm laser sheet and found that both detections follow the same curve. When comparing the maps of flame species reconstructed from the standard FRAME configuration and other configurations, there are some dissimilarities. These differences are attributed to minor changes in the imaging plane, optical alignment, laser path length, different modulation frequencies of the laser sheet, laser extinction, laser fluence, etc.

Reliable estimation of surface sensible and latent heat flux is the most important process to appraise energy and mass exchange among atmosphere and biosphere. In this study the surface energy fluxes were measured over an irrigated orange orchard during 2005-2008 monitoring periods using a Surface Renewal- Energy Balance approach. The experimental area is located in a representative orchard growing area of eastern Sicily (Italy). The performance of Surface Renewal (SR) analysis for estimating sensible heat flux (H) was analysed and evaluated in terms of correlation with H fluxes from the eddy covariance (EC) method. Study revealed that the mean available energy (RN- G) and latent heat flux (LE) were of about 300 W m-2 and 237 W m-2, respectively, during dry periods and unstable-case atmospheric conditions. The estimated crop coefficient Kc values for the orchard crop averaged close to 0.80, which is considerably higher than previous FAO studies that found the value to be 0.65 for citrus with 70% of ground cover. The intercepted photosynthetically active radiation (LI PAR) by the crop was measured and relationships between LAI and crop coefficient (Kc) were established.

Predictive approaches such as virtual screening have been used in drug discovery with the objective of reducing developmental time and costs. Current machine learning and network-based approaches have issues related to generalization, usability, or model interpretability, especially due to the complexity of target proteins’ structure/function, and bias in system training datasets. Here, we propose a new method “DRUIDom” (DRUg Interacting Domain prediction) to identify bio-interactions between drug candidate compounds and targets by utilizing the domain modularity of proteins, to overcome problems associated with current approaches. DRUIDom is composed of two methodological steps. First, ligands/compounds are statistically mapped to structural domains of their target proteins, with the aim of identifying their interactions. As such, other proteins containing the same mapped domain or domain pair become new candidate targets for the corresponding compounds. Next, a million-scale dataset of small molecule compounds, including those mapped to domains in the previous step, are clustered based on their molecular similarities, and their domain associations are propagated to other compounds within the same clusters. Experimentally verified bioactivity data points, obtained from public databases, are meticulously filtered to construct datasets of active/interacting and inactive/non-interacting drug/compound–target pairs (~2.9M data points), and used as training data for calculating parameters of compound–domain mappings, which led to 27,032 high-confidence associations between 250 domains and 8,165 compounds, and a finalized output of ~5 million new compound–protein interactions. DRUIDom is experimentally validated by syntheses and bioactivity analyses of compounds predicted to target LIM-kinase proteins, which play critical roles in the regulation of cell motility, cell cycle progression, and differentiation through actin filament dynamics. We showed that LIMK-inhibitor-2 and its derivatives significantly block the cancer cell migration through inhibition of LIMK phosphorylation and the downstream protein cofilin. One of the derivative compounds (LIMKi-2d) was identified as a promising candidate due to its action on resistant Mahlavu liver cancer cells. The results demonstrated that DRUIDom can be exploited to identify drug candidate compounds for intended targets and to predict new target proteins based on the defined compound–domain relationships. Datasets, results, and the source code of DRUIDom are fully-available at: https://github.com/cansyl/DRUIDom.

Purpose The purpose of this paper is to investigate the operation and management as well as the activities of tribal libraries in general, providing insights and implications in five areas: general operations and management, staffing and human resource management, financial operations, service and program management, and technology-related activities, using Oglala Lakota College (OLC) Library as a case study. Design/methodology/approach This paper uses information visualization techniques to create visual displays of report data collected from OLC Library. Visualizations were created using Tableau software to provide a quantitative, analytical, and evidence-based view of how tribal libraries operate and are managed. Findings Tribal populations can be well served despite limited funding and staff resources, providing academic and public library services on par with urban libraries. Research limitations/implications Drawing a story from the data proved to be difficult because a bias had been created by the legal service area that most tables of the state data set used to compare reported data. How tribal libraries translate value also posed another challenge. Because the research was conducted in a single tribal library, further research in different, expanded settings and contexts is suggested. Originality/value This study is one of the first to investigate tribal library activities by exploring report data and quantitatively using information visualization techniques.

A defence attorney is a significant and notable figure in criminal proceedings who for the whole procedural activity in a criminal case, in theory, should facilitate detecting and correcting possible judicial mistakes. In this respect, it is vital to conduct a series of research in order to highlight prevalent problems and issues of a defence attorney’s participation in criminal trials and to work out relevant recommendations for trial attorneys that would help to forestall, detect and prevent judicial mistakes. A specific condition of a defence attorney’s activity in the process of evidencing at a judicial examination is his awareness of the entire system of evidences presented by the prosecution and accusation conclusions in disputable classification situations. They should rely upon the fact that a judicial examination is performed under circumstances of direct examination of evidence, oral proceedings, publicity, invariability of the body of the court, as well as the fact that both the court and the representatives of the parties take part at the examination. Rather short deadlines of a judicial examination entails working under circumstances when decisions must be taken under extreme conditions, by applying tricks and methods that would allow examining all evidence in the most productive way. It makes sense for a defence attorney to state his activity position and determination of taking an active part in evidencing already at the beginning of court hearings, by filing a motion to summoning new witnesses, experts and specialists, disclosure of material evidence and documents or exclusion of evidence obtained in the way of violating the law. The author of the study applied general scientific methods of studying objective reality, peculiar to legal sciences: systematic document analysis, structural-functional analysis, critical approach, generalisation and prediction. As a result, the author provides numerous recommendations and rules for successful and immaculate defence in criminal trials. Aizstāvis ir nozīmīga, ievērojama figūra kriminālprocesā, jo aizstāvja procesuālajai darbībai krimināllietā teorētiski būtu jāatvieglo iespējamo tiesas kļūdu konstatēšana un labošana. Un šajā sakarā ir vitāli svarīgi veikt virkni pētījumu, lai izceltu problēmjautājumus, kas saistīti ar aizstāvja piedalīšanos krimināllietās, un izstrādātu tādas rekomendācijas aizstāvjiem, kas praktiskajā darbībā sekmētu tiesas kļūdu paredzēšanu, konstatēšanu un novēršanu. Par specifisku priekšnoteikumu aizstāvja darbībai pierādīšanas procesā tiesas izmeklēšanā ir uzskatāma viņa pilnā informētība par visu pierādījumu sistēmu lietā, kuru piedāvā valsts apsūdzība, un par valsts apsūdzības apsvērumiem strīdus krimināltiesiskās kvalifikācijas gadījumos. Aizstāvim jāņem vērā, ka tiesas izmeklēšana norit pierādījumu tiešas un nepastarpinātas pārbaudes apstākļos, ievērojot mutiskuma, publicitātes un tiesas sastāva nemainīguma principus. Pierādījumu pārbaudē piedalās gan tiesa, gan visi pārējie procesa dalībnieki, kas nav aizstāvības pusē. Likuma prasība ievērot saprātīgus lietas iztiesāšanas termiņus paredz saspringtu darbu, svarīgus lēmumus pieņemot ekstremālos procesuālos apstākļos, izmantojot tādus paņēmienus un metodes, kas veicinātu efektīvu pierādījumu kopuma pārbaudi un novērtēšanu. Aizstāvim būtu ieteicams deklarēt savu aktīvu procesuālo pozīciju un paust gatavību aktīvi piedalīties pierādīšanā jau tiesas izmeklēšanas sākumā, piesakot lūgumus par jauno liecinieku, ekspertu un/vai speciālistu aicināšanu uz tiesas sēdi, kā arī piesakot lūgumus par lietisko pierādījumu un/vai dokumentu pieprasīšanu un par pierādījumu, kas iegūti, pārkāpjot likumu, izslēgšanu no pierādījumu kopuma. Šajā pētījumā ir izmantotas vispārīgās zinātniskās metodes, kas sekmē objektīvās realitātes izzināšanu un ir raksturīgas tiesību zinātnei, proti: sistēmiskā dokumentu analīze, strukturāli funkcionālā analīze, kritiskā pieeja, vispārināšana un prognozēšana. Secinājumos tiek piedāvātas vairākas rekomendācijas veiksmīgai, efektīvai un nevainojamai aizstāvībai pirmās instances tiesā.

Named Entity Recognition and Classification (NERC) is a known and well-explored text analysis application that has been applied to various languages. We are presenting an automatic, highly multilingual news analysis system that fully integrates NERC for locations, persons and organisations with document clustering, multi-label categorisation, name attribute extraction, name variant merging and the calculation of social networks. The proposed application goes beyond the state-of-the-art by automatically merging the information found in news written in ten different languages, and by using the aggregated name information to automatically link related news documents across languages for all 45 language pair combinations. While state-of-the-art approaches for cross-lingual name variant merging and document similarity calculation require bilingual resources, the methods proposed here are mostly language-independent and require a minimal amount of monolingual language-specific effort. The development of resources for additional languages is therefore kept to a minimum and new languages can be plugged into the system effortlessly. The presented online news analysis application is fully functional and has, at the end of the year 2006, reached average usage statistics of 600,000 hits per day.

Accurate and consistent information on the area and production of field crops is vital for national and state planning and ensuring food security in India. Satellite-based remote sensing offers a suitable and cost-effective technique for regional- and national-scale crop monitoring. The use of remote sensing data for crop yield estimation has been demonstrated using a semi-physical approach with reasonable success. Assimilating remote sensing data with the DSSAT model and spectral indices-based regression analysis are promising methods for spatially estimating rice crop yields. Rice area and yield in the Cauvery delta zone of Tamil Nadu, India was estimated during samba (August–January) season in the years 2020–2021 using Sentinel 1A Synthetic Aperture Radar satellite data with three different spatial yield estimation methods, namely a spectral indices-based regression analysis, semi-physical approach, and integrating remote products with DSSAT crop growth model. A rice area map was generated for the study area using a rule-based classifier approach utilizing parameterization with a classification accuracy of 94.5% and a kappa score of 0.89. The total classified rice area in Cauvery Delta Region was 379,767 ha, and the Start of Season (SoS) maps for samba season revealed that the major planting period for rice was between 22 September and 9 November in 2020. The study also aimed to identify promising spatial yield estimation techniques for optimal rice yield prediction over large areas. Regression models resulted in rice yields of 3234 to 3905 kg ha−1 with a mean of 3654 kg ha−1. The net primary product was computed using the periodical PAR, fAPAR, Wstress, Tstress, and maximum radiation use efficiency in a semi-physical approach. The resultant rice yields ranged between 2652 and 3438 kg ha−1 with the mean of 3076 kg ha−1. During the integration of remote sensing products with crop growth models, LAI values were extracted from dB images and utilized to simulate rice yields in the range of 3684 to 4012 kg ha−1 with the mean of 3855 kg ha−1. When compared to the semi-physical approach, both integrating remote sensing products with the DSSAT crop growth model and spectral indices-based regression analysis had R2 greater than 0.80, NRMSE of less than 10%, and agreement of more than 90%, indicating that these two approaches could be used for spatial rice yield estimation.

Intravenous immunoglobulin preparations with proven effectiveness are widely used for treatment of various immunodeficient, autoimmune, inflammatory and infectious diseases. Nevertheless, algorithms for use of immunoglobulin preparations to correct immune status in burn disease, prevention, etc. have not been developed yet. Here we present the results of a prospective controlled study with 70 patients assessing effectiveness of using immunoglobulin preparations for intravenous administration in complex treatment of subjects suffering from extensive burns. Expanded immunological examination (more than 300 studies) in this patient cohort at different stages of burn disease consisted of phenotyping lymphocytes, granulocytes, monocytes (constitutive and activation markers, cell functional activity), immunoglobulin level and phagocyte oxygen metabolism. Data analysis included significant parameters only. Patient selection for using intravenous immunoglobulins to prevent or treat septic complications was performed by using the previously proposed 95%-specificity sepsis prognosis formula: LF 9.3%, NK cells 5%, HLA-DR+ Mn 50%, IgG 4.0-6.0 g/l, LII 4.0 u, CD64+ Gy 90-100%, N/I NF 21%. Immunosuppressive therapy with drug “GabriglobinIgG” at a dose of 50 ml per day for preventing infection spread in patients with burns for 5 days as well as for treatment of sepsis for 10 days, exerted pronounced immunomodulatory effect compared to control groups not only restoring baseline IgG deficiency, but also normalizing quantitative deficit of key immune parameters such as total lymphocytes, B and T cells, natural killer cells, cytotoxic T lymphocytes. Use of gabriglobin for sepsis prevention was effective in 72% of cases (control group without gabriglobin – 37%), so that clinical and immunological effectiveness was as high as 79% (control group – 32%). At the same time, along with conventional immune indicators in heavily burned patients, immune markers previously underestimated were: CD56+ and CD25+ monocytes, CD14+ and CD40+ granulocytes, CD40+ lymphocytes (B cell subset), various effector and regulatory natural killer subsets. It allowed to obtain radically new information about immune system state, inflammation, and bacterial complications in heavily burned patients and apply a personalized approach for immunocorrection by using several intravenous immunoglobulin preparations for effective comprehensive treatment of burn injury-related consequences.

Purpose – The purpose of this paper is to provide a case study of total cost of ownership (TOC) for Electronic Theses and Dissertations (ETD). Only few articles have been published to discuss the costs associated with repository and/or theses and dissertations (TD). Design/methodology/approach – The paper first provides literature reviews in costs associated with repository and TD. By using the DCC life cycle model, the author presents costs for each actionable category: create or receive, appraise & select, ingest, preservation action, store, access, use and reuse and transform. The paper presents four TOCs to illustrate the changes of TOCs from 2005 to current time. Findings – The paper gives one case study of the TOCs for ETD over the years, and illustrates how the University lowered the TOCs. The current ETD's TOC is on a par with these costs of two other studies published related to repository titles. The TOC has been decreased from the traditional paper-based TD of $75 per title to ETD of $69 in 2005. By removing the ProQuest processing fee of $55, the TOC decreased to $14.37 in 2010. The TOC is currently $6.33 per title after the ETD collection was migrated to the University of Arizona repository. Research limitations/implications – Readers shall be aware that there are no “transform” and little “preservation action” tasks performed. The current cost of “transform” is $0 due to the nature of ETD of its rigid format requirements, Originality/value – The paper fulfills the need to study costs associated with repository titles, especially ETD titles. It also provide a way to estimate costs for institutions planning to start ETD collections.

PurposeThe purpose of this article is to give an overview of the development of a Virtual Research Environment (VRE) conceptual model for the management of research data at a South African university.Design/methodology/approachThe research design of this article consists of empirical and non-empirical research. The non-empirical part consists of a critical literature review to synthesise the strengths, weaknesses (limitations) and omissions of identified VRE models as found in literature to develop a conceptual VRE model. As part of the critical literature review concepts were clarified and possible applications of VREs in research lifecycles and research data lifecycles were explored. The empirical part focused on the practical application of this model. This part of the article follows an interpretivist paradigm, and a qualitative research approach, using case studies as inquiry method. Case studies with a positivist perspective were selected through purposive sampling, and inferences were drawn from the sample to design and test a conceptual VRE model, and to investigate the management of research data through a VRE. Investigation was done through a process of participatory action research (PAR) and included semi-structured interviews and participant observation data collection techniques. Evaluation of findings was done through formative and summative evaluation.FindingsThe article presents a VRE conceptual model, with identified generic component layers and components that could potentially be applied and used in different research settings/disciplines. The article also reveals the role that VREs play in the successful management of research data throughout the research lifecycle. Guidelines for setting up a conceptual VRE model are offered.Practical implicationsThis article assisted in clarifying and validating the various components of a conceptual VRE model that could be used in different research settings and disciplines for research data management.Originality/valueThis article confirms/validates generic layers and components that would be needed in a VRE by synthesising these in a conceptual model in the context of a research lifecycle and presents guidelines for setting up a conceptual VRE model.

FR. Du point de vue sémio - narratif, ce travail démontre de quelles manières les clivages politiques entre les quotidiens et entre les journalistes s’effacent en matière d’assainissement urbain à Kinshasa. Il s’agit ici d’une découverte inattendue au regard de la littérature existante sur le journalisme, particulièrement en RDC, et qui établit notamment comment les contenus des médias congolais sont clivés selon leurs différentes orientations politiques. La présente étude procède par une analyse croisée des articles journalistiques dédiés à la problématique de gestion urbaine des déchets et des déclarations des auteurs de ces articles sur les conditions de production de ces derniers. Elle tient compte des acquis des travaux sur les rapports entre les médias (presse, radio, télévision) et le pouvoir politique en RDC, vu que la presse quotidienne considère la gestion urbaine des déchets comme une question éminemment politique. Dans une approche discursive des corpus mobilisés, inspirée par la narratologie sémiotique, l’auteur découvre l’uniformité des contenus de ces corpus à trois niveaux : 1. - au niveau du constat de l’ampleur de l’insalubrité publique après la fin du financement du Projet d’appui à la réhabilitation et l’assainissement urbain de la ville de Kinshasa (PARAU) par l’Union Européenne (UE), 2. - au niveau de la double incapacité du gouvernement congolais à financer l’évacuation des déchets des décharges publiques construites par l’UE et à faire respecter la loi sur la salubrité publique, 3. - au niveau de l’ambivalence du statut de la population vue par les chevaliers de la plume comme responsable et victime de l’insalubrité publique. Dans ces trois niveaux, les indices textuels concordent et les structures narratives des corpus analysés se ressemblent. Ceci constitue un bémol intéressant que cette étude apporte quant à l’effet du positionnement politique d’un journal sur son contenu. Un apport remarquable qui mérite des approfondissements ultérieurs. *** EN. From a semio-narrative point of view, this study demonstrates the ways political divisions between newspapers and between journalists are disappearing with respect to urban sanitation in Kinshasa. This is unexpected in light of existing literature on journalism, particularly in the DRC, which establishes how Congolese media is divided along lines defined by political orientation. This study cross-analyzes journalistic articles dedicated to the urban waste management issue and the discourses of these articles’ authors on the production conditions of the latter. It takes into account an analysis of the work on the relationship between the media (press, radio, television) and political power in the DRC, since the daily press considers urban waste management a highly political issue. Following a discursive approach of the mobilized corpus, inspired by a semiotic narratology, the author discovered uniformity in the content of this corpus in three instances: 1) the observation of the extent of public insalubrity after the end the financing of the Kinshasa City Rehabilitation and Urban Sanitation Support Project (PARAU) by the European Union (EU), 2) the incapacity of the Congolese government to finance the evacuation of waste from public landfills built by the EU and to enforce public health law, and 3) the ambivalence of the status of the population as seen by news writers as both responsible and victim of public insalubrity. In all three instances, the textual indices agree and the narrative structures of the corpus analyzed are similar. In this respect, this study provides an interesting caveat regarding the effect of newspapers’ political positioning on content and deserves further study. *** PT. Do ponto de vista semio-narrativo, este trabalho demonstra de que maneira as divisões políticas entre jornais e entre jornalistas estão desaparecendo em termos de saneamento urbano em Kinshasa. Esta é uma descoberta inesperada à luz da literatura existente sobre jornalismo, particularmente na DRC, que estabelece como o conteúdo dos congoleses é dividido de acordo com suas diferentes orientações políticas. Este estudo prossegue com uma análise cruzada de artigos jornalísticos dedicados à questão do gerenciamento de resíduos urbanos e as declarações dos autores desses artigos sobre as condições de produção deste último. Ele leva em conta as realizações do trabalho sobre a relação entre a mídia (imprensa, rádio, televisão) e o poder político na DRC, uma vez que a imprensa diária considera a gestão de resíduos urbanos uma questão altamente política. Numa abordagem discursiva, inspirada na narratologia semiótica, corpora mobilizada, o autor descobre a uniformidade do conteúdo desses corpora em três níveis: 1. - no nível da observação da extensão da insalubridade pública após o fim do financiamento do Projeto de Apoio à Reabilitação e Saneamento Urbano da Cidade de Kinshasa (PARAU) pela União Europeia (UE), 2. - a dupla incapacidade do governo congolês para financiar a evacuação de resíduos de aterros públicos pela UE e fazer cumprir a lei de saúde pública, 3. - no nível da ambivalência do status da população visto pelos cavaleiros da pena como responsáveis e vítimas de insalubridade pública. Nestes três níveis, os índices textuais concordam e as estruturas narrativas dos corpora são semelhantes. Este é um reverso interessante que este artigo apresenta sobre o efeito do posicionamento político de um jornal em seu conteúdo. Uma contribuição notável que merece mais estudos. ***

Purpose The purpose of this paper is to identify the frequency at which the users of agricultural libraries of Northern India tend to use the e-resources and explore the time they invest on average in a day in using e-resources. An effort has also been made to examine the state wise, university wise and user category wise tendency w.r.t. the frequency at which they use e-resources and the average time in a day they spend on their use. Design/methodology/approach A survey was adopted to conduct the study and a questionnaire was used as a data collection tool. The investigator also interacted with the librarians through telephone and also resorted to the e-mail communication to substantiate the responses and seek certain clarifications thereof. Statistical Package for Social Science was used to analyse the data on an empirical basis. χ2 test was used to derive an association between the variables and test the level of significance thereof. Findings It is found that the users of North Indian agricultural libraries have got a great tendency to use e-resources as majority of them are seen to use them “daily” and “2-3 times a week”. They prove to be voracious, prudent and sensible users in the sense that they spend 2 hrs in a day, 1 hr in a day and even 3 hrs in a day on usage of e-resources and thus go at par with the use pattern recorded in other domains of knowledge across India. No remarkable difference is witnessed among different categories of users w.r.t. frequency of use and the time spend on use of e-resources. Research limitations/implications This study has been conducted on e-resources only. Response to a similar set of questions need to be collected from the same library users to consolidate the facts about the print form of information and thus carryout a comparative study. Originality/value This is first work of its nature in Northern India with domain as agricultural libraries. The outcome of the study will enable the librarians to judiciously decide about the proportion at which the two formats of information resources need to be acquired and the facilities the libraries need to create for adequate, smooth and reliable access to two formats of information.

The embedding of active and passive components offers a wide range of benefits and potentials. With the use of laminate based technology concepts, components can be moved from surface mount into the build-up layers of substrates by embedding and by that, the third dimension will be available for further layers or assemblies. This paper will briefly discuss the necessary process steps of the embedded chip technology and more importantly it will focus on new efforts to actually use chip embedding concepts for the realization of standard-type industrial Quad Flat Packages with embedded chips (embedded chip QFN). Chips of 50 μm thickness, a pad pitch of 100 μm and pad size of 85 μm are die bonded to a copper substrate and subsequently embedded in RCC (Resin-Coated-Copper) layers by using vacuum lamination. The resulting QFN packages are only 160 μm thick and provide standard pads at 400 μm pitch and a total number of 84 I/Os with dimensions of 10x10 mm2. All embedded chip QFN packages at prototype level are manufactured in 250x300 mm2 panels. The present work will include QFN package reliability results after extensive testing of thermal cycling, temperature humidity, high temperature storage and pressure cooker test. The investigation of new embedding material combinations is one task to provide a reliable package. The main focus here is on new materials that offer improved package stability and also the ability to embed dies of different thickness. Together with material suppliers improved resin formulations as well as the introduction of filler and glass fibers into the resin layers is currently realized and tested. In order to realize a further miniaturization ultra fine pitch (UFP) and fine line (UFL) approaches will be presented. For a UFP approach the goal is to develop the laser via technology further towards their limits as well as the investigation of new concepts. UFP requires the use of a semi additive patterning process. Here LDI processing is being used for all new generation chip embedded packages due to its potential for very fine copper patterning. Results on very fine L/S of 15–20μm will be shown based on the semi-additive processes on an ultra thin initial 1–2μm copper foil. Finally different applications will be presented. In an industrial cooperation different power package developments are ongoing. Here single and multi chips modules are realized as well as multiple routing layers. The combination of power and logic is one of the main challenges here, due to the need of thick copper layers for the power part and the more fine pitch demands for the controller chips. Process developments and results will be discussed in detail.

Abstract The rearrangement hIn1(I) was isolated as a crossover suppressor for the right end of linkage group (LG) I. By inducing genetic markers on this crossover suppressor and establishing the gene order in the homozygote, hIn1(I) was demonstrated to be the first genetically proven inversion in Caenorhabditis elegans. hIn1(I) extensively suppresses recombination in heterozygotes in the right arm of chromosome I from unc-75 to unc-54. This suppression is associated with enhancement of recombination in other regions of the chromosome. The enhancement observed maintains the normal distribution of events but does not extend to other chromosomes. The genetic distance of chromosome I in inversion heterozygotes approaches 50 map units (m.u.), approximately equal to one chiasma per meiosis. This value is maintained in hIn1(I)/szT1(I;X) heterozygotes indicating that small homologous regions can pair and recombine efficiently. hIn1(I)/hT2(I;III) heterozygotes share no uninverted homologous regions and segregate randomly, suggesting the importance of chiasma formation in proper segregation of chromosomes. The genetic distance of chromosome I in these heterozygotes is less that 1 m.u., indicating that crossing over can be suppressed along an entire chromosome. Since one of our goals was to develop an efficient balancer for the right end of LGI, the effectiveness of hIn1(I) as a balancer was tested by isolating and maintaining lethal mutations. The meiotic behaviour of hIn1(I) is consistent with other genetic and cytogenetic data suggesting the meiotic chromosomes are monocentric. Rare recombinants bearing duplications and deficiencies of chromosome I were recovered from hIn1(I) heterozygotes, leading to the proposal the inversion was paracentric.

Background. Te modern information space containing both reliable and quasi-scientifc information has a signifcant impact on the formation of students’ scientifc worldview. Objective. To obtain an empirical support for the theoretical model of the formation of scientifc worldview in the middle-adolescent students which was formulated in the framework of the cultural-historical conception. Methods. A special questionnaire was developed containing 16 pairs of statements. Each pair presented both scientifc and an everyday interpretation of a natural science phenomenon. Te respondents had to choose the answer considered to be correct. When processing the data, the number of answers corresponding to the modern scientifc concepts was taken into account. Sample. Te study involved 200 high school students and 196 junior college students aged 16–18 years, a total of 396 people (232 girls and 164 boys). Results. Te study has revealed that the worldview of middle-adolescent students is predominantly characterized by an average level of scientifc concepts and presents an individual combination of scientifc and everyday knowledge. It has been found out that boys demonstrate a signifcantly higher level of scientifc views than girls. College students’ outlook tends to be more scientifc than that of high school students, but the diferences linked to the type of educational institution do not reach statistica signifcance. Conclusion. Te theoretical model of scientifc worldview formation in the middle adolescence proposed by L.I. Bozhovich in the framework of cultural-historical approach is not confrmed. It is assumed that the key factor in the formation of an individual’s scientifc worldview is not the scope of one’s knowledge but its personal meaning. Te data obtained expand understanding of formation of the students’ worldview and provide new insights into the content and structure of modern individual’s outlook.

We compare the results of the analysis of hemispherical images (of a broadleaved and a coniferous forest) obtained using the Gap Light Analyser (GLA) software and the results obtained by analyzing the same images with the aid of WinScanopy. The two packages were used to calculate relative total, relative diffuse and relative direct transmittance, canopy openness, and leaf area index. Our aim was to find out whether it is possible to compare the studies using different software packages for determining light conditions. The binary pixel classification of images of canopy and sky was performed automatically (in the case of Gap Light Analyser, using the SideLook programme). The threshold values determined by the SideLook programme were lower compared to the WinScanopy, which was also reflected in the evaluated output results. There was a strong positive correlation between the results obtained with the two software packages (R2 ranges from 0.814 to 0.999). However, when the Gap Light Analyser analysis was applied to the threshold values obtained with the SideLook, the output results mostly manifested systematic differences in comparison with the output results obtained using the WinScanopy. Using the same threshold value in both programmes, the differences between the output values were quite small (a minimum of 0.038 m2.m&ndash;2 for LAI in the spruce forest and a maximum of 0.738% for total relative transmittance also in the spruce forest). The differences in some characteristics were statistically significant, on the other hand, both the photo series had only the identical direct transmittance values. The observed differences can be explained by differences in the calibration of the used camera-lens pair, different image registration techniques and different theoretical background and models used in the two software packages. It follows that it is also necessary to be aware of possible differences when comparing the outputs of the two compared software packages analyzing photos obtained applying the same methodical approach.

Abstract Although balanced translocations often result in the formation of chimaeric fusion genes, the analysis of unbalanced translocations has largely failed to identify target loci. This is due to the heterogeneity of the chromosomal breakpoints and the multiplicity of partner chromosomes. One such example is that of dicentric chromosomes found in patients with acute lymphoblastic leukaemia (ALL). We investigated patients with dic(7;9)(p11;p11~13) [n=13], dic(9;12)(p11~13;p13) [n=38] and dic(9;20)(p11~13;q11) [n=59] to determine the breakpoints of these translocations. FISH with probes for 9p showed that breakpoints were heterogeneous [n=54]. Apart from two cases with dic(9;20), all showed either deletion of the entire PAX5 gene [53.7%, n=29] or a breakpoint within the gene [42.6%, n=23]. For those cases with breakpoints within PAX5, FISH identified ETV6 as the partner in dic(9;12) cases (18/19 cases tested). Sequencing showed a novel breakpoint within intron 1 of ETV6 in a one case of dic(9;12). Molecular copy number counting (MCC) and long distance inverse PCR (LDI-PCR) identified five novel fusion sequences in which PAX5 partnered the LOC392027 (7p12.1), SLCO1B3 (12p12), ASXL1 (20q11.1), KIF3B (20q11.21) and C20orf112 (20q11.1) loci. The PAX5-ASXL1 and PAX5-KIF3B fusion sequences were in opposing orientation, the remaining three fusions were in the same orientation but out of frame, implicating loss of PAX5 function. To confirm the significance of PAX5 disruption, we demonstrated that both the deletion and gene fusion events resulted in the same under-expression of PAX5 exons 1–2 (p<0.04), and 4–5 (p<0.04) in the patients with dicentric chromosomes, in association with differential expression of the PAX5 target genes, EBF1 (p<0.001), ALDH1A1 (p<0.001), ATP9A (p<0.01) and FLT3 (p<0.006). Genomic quantitative PCR (gqPCR) confirmed the heterozygous loss of PAX5 [n=16] and showed homozygous deletions involving the homologous allele in two patients. Mutation analysis [n=20] identified two cases with a single base pair deletion of exon 8 and a single base pair insertion into exon 2, both of which would translate into a truncated PAX5 protein. This is further support that the formation of the dicentric chromosome provided leukemic potential by abrogating normal PAX5 function in these cases. The same analysis of chromosome 20 in 26 dic(9;20) cases highlighted ASXL1 as the potential target gene in 62% [n=16] patients with the dic(9;20) tested, manifesting as recurrent fusion events and deletions as shown for PAX5. Three additional fusion sequences were identified; involving ASXL1, FRG1B (20q11.1) and LOC149950 (20q11.21) fused to sequence centromeric of PAX5. Here, we have shown for the first time, that specific gene loci may be the target of heterogeneous breakpoints in human cancer, acting through a variety of mechanisms. Although several investigations have failed to identify the key molecular events in patients with dicentric chromosomes, we report PAX5 and ASXL1 as key target genes, as a consequence of their involvement in multiple fusion genes and by deletion. This approach has considerable application to the identification of cancer genes in solid tumours, where unbalanced chromosomal rearrangements are particularly prevalent while relatively few genes have been identified. In the absence of a dicentric chromosome, PAX5 is also targeted by interstitial deletions and copy number neutral LOH events, further supporting the importance of investigating the underlying molecular basis of unbalanced translocations. From the expansion of this approach into other tumour types, a large number of novel genes will surely emerge, expanding our understanding of carcinogenesis and ultimately leading to improved management of patients with cancer.

Abstract Background.Targeting HER2 gene amplification is one of the great achievements in oncology resulting in the use of a wide array of anti-HER2 agents in the clinic. Unfortunately, 20% of patients still relapse with secondary organ metastasis and are currently incurable. While only 1.6% of primary non-HER2-amplified ER+ breast cancers harbor HER2 mutations, 6-10% of all metastatic breast cancers harbor HER2 mutations, suggesting their causal role in contributing to metastasis. The clinical value of HER2 activating mutations is being tested with the pan-HER tyrosine kinase inhibitor neratinib in phase II clinical trials (NCT01670877, NCT01953926, and NCT02465060). To date, neratinib has elicited only modest responses in ER+ breast cancer, often rapidly followed by progression. This study characterizes HER2-mutant induced resistance to endocrine therapy or neratinib induced resistance and resulting metastasis, in order to determine a more effective rational therapeutic approach for treating ER+ HER2-mutant breast cancer. Methods.HER2 mutation frequency and its impact on patient outcome was determined using METABRIC primary breast cancer (BC) and MSK IMPACT metastatic BC ER+ sequencing studies. Effects of estrogen (E2), fulvestrant, or neratinib on cell growth and HER2 signaling were examined on ER+/ILC cells (MM134) stably expressing HER2/WT, HER2/S310F, and HER2/L755S. Cell growth was measured using CellTiter-Glo and HER2 signaling was analyzed by western blot analysis. Additionally, the effect of these ER+/ILC and IDC HER2 mutations on tumor growth and endocrine or neratinib treatment resistance was determined using fat pad injections and MIND xenografts in NOD-scid gamma mice. Results.We searched ER+ sequencing datasets and identified HER2 mutations that are highly enriched in ER+ ILC as compared to ER+ IDC. These activating HER2 mutations in ER+ ILC are associated with early relapse and poor overall survival. Moreover, we are finding that ILC patients harboring the recurrent HER2/L755S mutation have worse overall survival compared to non-mutant HER2 ILC. MM134 cells expressing HER2/S310F and HER2/L755S show increased cell growth, strongly activated autophosphorylation of HER2, and increased downstream signaling (pMAPK and pAKT) as compared to cells expressing HER2/WT upon treatment with fulvestrant (1μM). Three clinically relevant in vivo models including ILC HER2/L755S Mammary INtraDuctal (MIND) xenografts, IDC HER2/L755S fat pad xenografts, and IDC HCI-003 (an ER+ patient-derived xenograft (PDX) naturally harboring the exon 20 activating HER2G778_P780 dup) exhibit fulvestrant and neratinib resistance and lung and ovary metastases. In addition, we find that HER2 mutations induced mTOR signaling. In contrast, however, the pan-HER drug poziotinib does potently inhibit tumor growth and organ-specific metastasis and perturbs mTOR activation in these models. Conclusion.We demonstrate that clinically associated HER2 mutations drive endocrine therapy or neratinib resistance and poor patient outcome in ER+ patients. Our data propose the use of the irreversible pan-HER TKI poziotinib for treating endocrine therapy or neratinib refractory ER+ HER2-mutant metastatic breast cancer. Citation Format: Shyam. M Kavuri, Rashi Kalra, Ching Hui Chen, Junkai Wang, Ahmad Bin Salam, Lacey Dobrolecki, Alaina Lewis, Christina Sallas, Clayton Yates, Carolina Gutierrez, Balasubramanyam Karanam, Meenakshi Anurag, Bora Lim, Matthew Ellis. Distinct HER2 allele specific therapeutic response and preclinical efficacy of poziotinib in metastatic ER+ HER2 mutant breast cancer [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P2-13-24.

Endohedral metallofullerenes (EMFs), which are the hybrid materials consisting of fullerene cage and encapsulated metal(s), are one of the well-studied nanocarbon materials during the past 3 decades.[1] As a result of significant progress in the development of synthetic procedures and purification processes, a variety of different types of EMFs, such as mono-metallofullerenes, di-metallofullerenes and metal-cluster-fullerenes with various carbon-cage sizes, are currently available. We previously reported development of an efficient method to access EMFs, so-called plasma implantation.[2] This approach allowed us to achieve scalable synthesis of lithium-ion-encapsulated [60]fullerene Li+@C60 X−, a stable ionic form of lithium encapsulated fullerene. The compound can be regarded as “ion-endohedral fullerene” consisting of encapsulated ion, neutral fullerene cage and external counter anion X−, and it should not be categorized into general metallofullerenes because of its ion-pair structure. Despite the unique properties arising from its ionic natures, no other ionic metallofullerenes have been well studied so far.[3] For systematic and deeper studies on ion-endohedral fullerenes, we focused on Li+-endohedral [70]fullerene (Li+@C70) because C70 is the second abundant and therefore widely studied fullerene next to C60. The Li+@C70 was synthesized as PF6 − and TFSI− (TFSI=bis(trifluoromethanesulfonyl)imide) salts using our improved plasma implantation method followed by oxidative purification process. 7Li NMR spectrum showed a sharp singlet signal at −32.81 ppm (vs LiCl/D2O standard) indicating that the Li+ was encapsulated in the C70 cage. 13C NMR spectrum showed 5 aromatic peaks, which evidenced the defectless C70 structure. In addition to the NMR signals originated from the Li+@C70 core, 19F and 31P NMR spectra showed clear signals assigned to each external counter anion. The structure of Li+@C70 was unambiguously confirmed by X-ray crystal structure analysis of the TFSI− salt. The crystal structure showed encapsulation of Li+ by C70 cage as well as the 1:1 ion-paired structure of the cationic Li+@C70 core and external TFSI− anion. Moreover, we also performed collision experiments using sodium plasma to synthesize sodium-ion-endohedral [60]fullerene. Laser desorption ionization (LDI) mass spectrum of the crude products showed signals at m/z= 720 and 743 assignable to the molecular ion of empty C60 and the Na+@C60, respectively. The target compound was isolated as TFSI− salt by oxidative purification process followed by electrolyte-added HPLC. There was only a mass peak at m/z= 743 after the purification, which evidenced the complete removal of empty C60. 23Na NMR spectrum showed a sharp singlet signal at −59.6 ppm (vs NaCl/D2O standard), evidenced the formation of the target Na+@C60. References [1] (a) Shinohara, H. Rep. Prog. Phys. 2000, 63, 843; (b) Popov, A. A. et al. Chem. Rev. 2013, 113, 5989. [2] Aoyagi, S. et al. Nature Chem. 2010, 2, 678. [3] Matsuo, Y. et al. Endohedral Lithium-Containing Fullerenes: Preparation, Derivatization, and Application; Springer: Singapore, 2017.

OBJECTIVES/GOALS: Characterize formal informatics methods and approaches for enabling reproducible translational research. Education of reproducible methods to translational researchers and informaticians. METHODS/STUDY POPULATION: We performed a scoping review [1] of selected informatics literature (e.g. [2,3]) from PubMed and Scopus. In addition we reviewed literature and documentation of translational research informatics projects [4–21] at the University of Utah. RESULTS/ANTICIPATED RESULTS: The example informatics projects we identified in our literature covered a broad spectrum of translational research. These include research recruitment, research data requisition, study design and statistical analysis, biomedical vocabularies and metadata for data integration, data provenance and quality, and uncertainty. Elements impacting reproducibility of research include (1) Research Data: its semantics, quality, metadata and provenance; and (2) Research Processes: study conduct including activities and interventions undertaken, collections of biospecimens and data, and data integration. The informatics methods and approaches we identified as enablers of reproducibility include the use of templates, management of workflows and processes, scalable methods for managing data, metadata and semantics, appropriate software architectures and containerization, convergence methods and uncertainty quantification. In addition these methods need to be open and shareable and should be quantifiable to measure their ability to achieve reproducibility. DISCUSSION/SIGNIFICANCE OF IMPACT: The ability to collect large volumes of data collection has ballooned in nearly every area of science, while the ability to capturing research processes hasn’t kept with this pace. Potential for problematic research practices and irreproducible results are concerns.Reproducibility is a core essentially of translational research. Translational research informatics provides methods and means for enabling reproducibility and FAIRness [22] in translational research. In addition there is a need for translational informatics itself to be reproducible to make research reproducible so that methods developed for one study or biomedical domain can be applied elsewhere. Such informatics research and development requires a mindset for meta-research [23].The informatics methods we identified covers the spectrum of reproducibility (computational, empirical and statistical) and across different levels of reproducibility (reviewable, replicable, confirmable, auditable, and open or complete) [24–29]. While there are existing and ongoing efforts in developing informatics methods for translational research reproducibility in Utah and elsewhere, there is a need to further develop formal informatics methods and approaches: the Informatics of Research Reproducibility.In this presentation, we summarize the studies and literature we identified and discuss our key findings and gaps in informatics methods for research reproducibility. We conclude by discussing how we are covering these topics in a translational research informatics course.1.Pham MT, Rajić A, Greig JD, Sargeant JM, Papadopoulos A, McEwen SA. A scoping review of scoping reviews: advancing the approach and enhancing the consistency. Res Synth Methods. 2014 Dec;5(4):371–85.2.McIntosh LD, Juehne A, Vitale CRH, Liu X, Alcoser R, Lukas JC, Evanoff B. Repeat: a framework to assess empirical reproducibility in biomedical research. BMC Med Res Methodol [Internet]. 2017 Sep 18 [cited 2018 Nov 30];17. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604503/3.Denaxas S, Direk K, Gonzalez-Izquierdo A, Pikoula M, Cakiroglu A, Moore J, Hemingway H, Smeeth L. Methods for enhancing the reproducibility of biomedical research findings using electronic health records. BioData Min. 2017;10:31.4.Burnett N, Gouripeddi R, Wen J, Mo P, Madsen R, Butcher R, Sward K, Facelli JC. Harmonization of Sensor Metadata and Measurements to Support Exposomic Research. In: 2016 International Society of Exposure Science [Internet]. Research Triangle Park, NC, USA; 2017 [cited 2017 Jun 17]. Available from: http://www.intlexposurescience.org/ISES20175.Butcher R, Gouripeddi RK, Madsen R, Mo P, LaSalle B. CCTS Biomedical Informatics Core Research Data Service. In Salt Lake City; 2016.6.Cummins M, Gouripeddi R, Facelli J. A low-cost, low-barrier clinical trials registry to support effective recruitment. In Salt Lake City, Utah, USA; 2016 [cited 2018 Nov 30]. Available from: //campusguides.lib.utah.edu/UtahRR16/abstracts7.Gouripeddi R, Warner P, Madsen R, Mo P, Burnett N, Wen J, Lund A, Butcher R, Cummins MR, Facelli J, Sward K. An Infrastructure for Reproducibile Exposomic Research. In: Research Reproducibility 2016 [Internet]. Salt Lake City, Utah, USA; 2016 [cited 2018 Nov 30]. Available from: //campusguides.lib.utah.edu/UtahRR16/abstracts8.Eilbeck K, Lewis SE, Mungall CJ, Yandell M, Stein L, Durbin R, Ashburner M. The Sequence Ontology: a tool for the unification of genome annotations. Genome Biol. 2005;6:R44.9.Gouripeddi R, Cummins M, Madsen R, LaSalle B, Redd AM, Presson AP, Ye X, Facelli JC, Green T, Harper S. Streamlining study design and statistical analysis for quality improvement and research reproducibility. J Clin Transl Sci. 2017 Sep;1(S1):18–9.10.Gouripeddi R, Eilbeck K, Cummins M, Sward K, LaSalle B, Peterson K, Madsen R, Warner P, Dere W, Facelli JC. A Conceptual Architecture for Reproducible On-demand Data Integration for Complex Diseases. In: Research Reproducibility 2016 (UtahRR16) [Internet]. Salt Lake City, Utah, USA; 2016 [cited 2017 Apr 25]. Available from: https://zenodo.org/record/16806711.Gouripeddi R, Lane E, Madsen R, Butcher R, LaSalle B, Sward K, Fritz J, Facelli JC, Cummins M, Shao J, Singleton R. Towards a scalable informatics platform for enhancing accrual into clinical research studies. J Clin Transl Sci. 2017 Sep;1(S1):20–20.12.Gouripeddi R, Deka R, Reese T, Butcher R, Martin B, Talbert J, LaSalle B, Facelli J, Brixner D. Reproducibility of Electronic Health Record Research Data Requests. In Washington, DC, USA; 2018 [cited 2018 Apr 21]. Available from: https://zenodo.org/record/1226602#.WtvvyZch27013.Gouripeddi R, Mo P, Madsen R, Warner P, Butcher R, Wen J, Shao J, Burnett N, Rajan NS, LaSalle B, Facelli JC. A Framework for Metadata Management and Automated Discovery for Heterogeneous Data Integration. In: 2016 BD2K All Hands Meeting [Internet]. Bethesda, MD; November 29-30 [cited 2017 Apr 25]. Available from: https://zenodo.org/record/16788514.Groat D, Gouripeddi R, Lin YK, Dere W, Murray M, Madsen R, Gestaland P, Facelli J. Identification of High-Level Formalisms that Support Translational Research Reproducibility. In: Research Reproducibility 2018 [Internet]. Salt Lake City, Utah, USA; 2018 [cited 2018 Oct 30]. Available from: //campusguides.lib.utah.edu/UtahRR18/abstracts15.Huser V, Kahn MG, Brown JS, Gouripeddi R. Methods for examining data quality in healthcare integrated data repositories. Pac Symp Biocomput Pac Symp Biocomput. 2018;23:628–33.16.Lund A, Gouripeddi R, Burnett N, Tran L-T, Mo P, Madsen R, Cummins M, Sward K, Facelli J. Enabling Reproducible Computational Modeling: The Utah PRISMS Ecosystem. In Salt Lake City, Utah, USA; 2018 [cited 2018 Oct 30]. Available from: //campusguides.lib.utah.edu/UtahRR18/abstracts17.Pflieger LT, Mason CC, Facelli JC. Uncertainty quantification in breast cancer risk prediction models using self-reported family health history. J Clin Transl Sci. 2017 Feb;1(1):53–9.18.Shao J, Gouripeddi R, Facelli J. Improving Clinical Trial Research Reproducibility using Reproducible Informatics Methods. In Salt Lake City, Utah, USA; 2018 [cited 2018 Oct 30]. Available from: //campusguides.lib.utah.edu/UtahRR18/abstracts19.Shao J, Gouripeddi R, Facelli JC. Semantic characterization of clinical trial descriptions from ClincalTrials.gov and patient notes from MIMIC-III. J Clin Transl Sci. 2017 Sep;1(S1):12–12.20.Tiase V, Gouripeddi R, Burnett N, Butcher R, Mo P, Cummins M, Sward K. Advancing Study Metadata Models to Support an Exposomic Informatics Infrastructure. In Ottawa, Canada; 2018 [cited 2018 Oct 30]. Available from: = http://www.eiseverywhere.com/ehome/294696/638649/?&t=8c531cecd4bb0a5efc6a0045f5bec0c321.Wen J, Gouripeddi R, Facelli JC. Metadata Discovery of Heterogeneous Biomedical Datasets Using Token-Based Features. In: IT Convergence and Security 2017 [Internet]. Springer, Singapore; 2017 [cited 2017 Sep 6]. p. 60–7. (Lecture Notes in Electrical Engineering). Available from: https://link.springer.com/chapter/10.1007/978-981-10-6451-7_822.Wilkinson MD, Dumontier M, Aalbersberg IjJ, Appleton G, Axton M, Baak A, Blomberg N, Boiten J-W, da Silva Santos LB, Bourne PE, Bouwman J, Brookes AJ, Clark T, Crosas M, Dillo I, Dumon O, Edmunds S, Evelo CT, Finkers R, Gonzalez-Beltran A, Gray AJG, Groth P, Goble C, Grethe JS, Heringa J, ’t Hoen PAC, Hooft R, Kuhn T, Kok R, Kok J, Lusher SJ, Martone ME, Mons A, Packer AL, Persson B, Rocca-Serra P, Roos M, van Schaik R, Sansone S-A, Schultes E, Sengstag T, Slater T, Strawn G, Swertz MA, Thompson M, van der Lei J, van Mulligen E, Velterop J, Waagmeester A, Wittenburg P, Wolstencroft K, Zhao J, Mons B. The FAIR Guiding Principles for scientific data management and stewardship. 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Christianity was the religion of spirit (and freedom), and critiqued Islam as a religion of flesh (and slavery); later, Christianity was the religion of reason, and critiqued Islam as the religion of fideism; later still, Christianity was the religion of the critique of religion, and critiqued Islam as the most atavistic of religions. Even now, when the West has critiqued its own Chris- tianity enough to be properly secular (because free, rational, and critical), it continues to critique Islam for being not secular enough. In contrast to Christianity or post-Christian secularism, then, and despite their best ef- forts, Islam does not know (has not learned from) critique. This sentiment is articulated at multiple registers, academic and popular and governmen- tal: Muslims are fanatical about their repressive law; they interpret things too literally; Muslims do not read their own revelation critically, let alone literature or cartoons; their sartorial practices are unreasonable; the gates of ijtihād closed in 900CE; Ghazali killed free inquiry in Islam… Such claims are ubiquitous enough to be unremarkable, and have political traction among liberals and conservatives alike. “The equation of Islam with the ab- sence of critique has a longer genealogy in Western thought,” Irfan Ahmad writes in this book, “which runs almost concurrently with Europe’s colonial expansion” (8). Luther and Renan figure in that history, as more recently do Huntington and Gellner and Rushdie and Manji.Meanwhile in the last decade an interdisciplinary conversation about the stakes, limits, complicities, and possibilities of critique has developed in the anglophone academy, a conversation of which touchstones include the polemical exchange between Saba Mahmood and Stathis Gourgouris (2008); the co-authored volume Is Critique Secular? (2009), by Talal Asad, Wendy Brown, Judith Butler, and Mahmood; journal special issues dedi- cated to the question (e.g. boundary 2 40, no. 1 [2013]); and Gourgouris’s Lessons in Secular Criticism (2013), among others. At the same time, the discipline of religious studies remains trapped in an argument over the lim- its of normative analysis and the possibility of critical knowledge.Religion as Critique: Islamic Critical Thinking from Mecca to the Mar- ketplace seeks to turn these debates on their head. Is critique secular? Decidedly not—but understanding why that is, for Ahmad, requires revising our understanding of critique itself. Instead of the object of critique, reli- gion here emerges as an agent of critique. By this account, God himself is the source of critique, and the prophets and their heirs are “critics par ex- cellence” (xiv). The book is divided into two parts bookended by a prologue and epilogue. “Formulation” comprises three chapters levying the shape of the argument. “Illustration” comprises three chapters taking up the case study of the South Asian reformer Abul-A‘la Maududi and his critics (es- pecially regarding his views on the state and on women) as well as a fourth chapter that seeks to locate critique in the space of the everyday. There are four theses to Ahmad’s argument, none of them radically original on their own but newly assembled. As spelled out in the first chap- ter (“Introduction”), the first thesis holds that the Enlightenment reconfig- uration of Christianity was in fact an ethnic project by which “Europe/the West constituted its identity in the name of reason and universalism against a series of others,” among them Islam (14). The second thesis is that no crit- ic judges by reason alone. Rather, critique is always situated, directed, and formed: it requires presuppositions and a given mode to be effective (17). The third thesis is that the Islamic tradition of critique stipulates the com- plementarity of intellect (‘aql, dimāgh) and heart (qalb, dil); this is a holistic anthropology, not a dualistic one. The fourth thesis is that critique should not be understood as the exclusive purview of intellectuals (especially when arguing about literature) or as simply a theoretical exercise. Instead, cri- tique should be approached as part of life, practiced by the literate and the illiterate alike (18).The second chapter, “Critique: Western and/or Islamic,” focuses on the first of these theses. The Enlightenment immunized the West from critique while subjecting the Rest to critique. An “anthropology of philosophy” approach can treat Kant’s transcendental idealism as a social practice and in doing so discover that philosophy is “not entirely independent” from ethnicity (37). The certainty offered by the Enlightenment project can thus be read as “a project of security with boundaries.” Ahmad briefly consid- ers the place of Islam across certain of Kant’s writings and the work of the French philosophes; he reads their efforts to “secure knowledge of humani- ty” to foreclose the possibility of “knowledge from humanity” (42), namely Europe’s others. Meanwhile, ethnographic approaches to Muslim debates shy away from according them the status of critique, but in so doing they only maintain the opposition between Western reason and Islamic unrea- son. In contrast to this view (from Kant through Foucault), Ahmad would rather locate the point of critical rupture with the past in the axial age (800-200BCE), which would include the line of prophets who reformed (critiqued) their societies for having fallen into corruption and paganism. This alternative account demonstrates that “critical inquiry presupposes a tradition,” that is, that effective critique is always immanent (58). The third chapter, “The Modes: Another Genealogy of Critique,” con- tests the reigning historiography of “critique” (tanqīd/naqd) in South Asia that restricts it to secular literary criticism. Critique (like philosophy and democracy) was not simply founded in Grecian antiquity and inherited by Europe: Ahmad “liberates” critique from its Western pedigree and so allows for his alternative genealogy, as constructed for instance through readings of Ghalib. The remainder of the chapter draws on the work of Maududi and his critics to present the mission of the prophets as critiquing to reform (iṣlāḥ) their societies. This mandate remains effective today, and Maududi and his critics articulate a typology of acceptable (tanqīd) and unacceptable (ta‘īb, tanqīṣ, tazhīk, takfīr, etc.) critiques in which the style of critique must be considered alongside its object and telos. Religion as Critique oscillates between sweeping literature reviews and close readings. Readers may find the former dizzying, especially when they lose in depth what they gain in breadth (for example, ten pages at hand from chapter 2 cite 44 different authors, some of whom are summarizing or contesting the work of a dozen other figures named but not cited di- rectly). Likewise there are moments when Ahmad’s own dogged critiques may read as tendentious. The political purchase of this book should not be understated, though the fact that Muslims criticize themselves and others should come as no surprise. Yet it is chapters 4–6 (on Maududi and his critics) which substantiate the analytic ambition of the book. They are the most developed chapters of the book and detail a set of emerging debates with a fine-grained approach sometimes found wanting elsewhere (espe- cially in the final chapter). They show how Islam as a discursive tradition is constituted through critique, and perhaps always has been: for against the disciplinary proclivities of anthropologists (who tend to emphasize discon- tinuity and rupture, allowing them to discover the modern invention of traditions), Ahmad insists on an epistemic connection among precolonial and postcolonial Islam. This connection is evident in how the theme of rupture/continuity is itself a historical topos of “Islamic critical thinking.” Chapter 4 (“The Message: A Critical Enterprise”) approaches Maududi (d. 1979) as a substantial political thinker, not simply the fundamentalist ideologue he is often considered to be. Reading across Maududi’s oeuvre, Ahmad gleans a political-economic critique of colonial-capitalist exploita- tion (95), a keen awareness of the limits of majoritarian democracy, and a warning about the dispossessive effects of minoritization. Maududi’s Isla- mism (“theodemocracy”), then, has to be understood within his broader project of the revival of religion to which tanqīd (“critique”), tajdīd (“re- newal”), and ijtihād (“understanding Islam’s universal principles to de- termine change”) were central (103). He found partial historical models for such renewal in ‘Umar b. ‘Abd al-‘Aziz, Ghazali, Ibn Taymiyya, Ahmad Sirhindi, and Shah Wali Ullah. A key element of this critique is that it does not aim to usher in a different future. Instead it inhabits a more complicated temporality: it clarifies what is already the case, as rooted in the primordial nature of humans (fiṭra), and in so doing aligns the human with the order of creation. This project entails the critique and rejection of false gods, in- cluding communism, fascism, national socialism, and capitalism (117). Chapter 5 (“The State: (In)dispensible, Desirable, Revisable?”) weaves together ethnographic and textual accounts of Maududi’s critics and de- fenders on the question of the state (the famous argument for “divine sov- ereignty”). In doing so the chapter demonstrates how the work of critique is undertaken in this Islamic tradition, where, Ahmad writes, “critique is connected to a form of life the full meaning of which is inseparable from death” (122). (This also means that at stake in critique is also the style and principles of critique.) The critics surveyed in this chapter include Manzur Nomani, Vahiduddin Khan, Abul Hasan Ali Nadvi, Amir Usmani, Sadrud- din Islahi, Akram Zurti, Rahmat Bedar, Naqi Rahman, Ijaz Akbar, and others, figures of varying renown but all of whom closely engaged, defend- ed, and contested Maududi’s work and legacy in the state politics of his Jamaat-e Islami. Chapter 6 (“The Difference: Women and In/equality”) shows how Maududi’s followers critique the “neopatriarchate” he proposes. Through such critique, Ahmad also seeks to affirm the legitimacy of a “nonpatri- archal reading of Islam” (156). If Maududi himself regarded the ḥarem as “the mightiest fortress of Islamic culture” (159)—a position which Ahmad notes is “enmeshed in the logic of colonial hegemony”—he also desired that women “form their own associations and unbiasedly critique the govern- ment” (163). Maududi’s work and legacy is thus both “disabling” and “en- abling” for women at the same time, as is borne out by tracing the critiques it subsequently faced (including by those sympathetic to his broader proj- ect). The (male) critics surveyed here include Akram Zurti, Sultan Ahmad Islahi, Abdurrahman Alkaf, and Mohammad Akram Nadwi, who seriously engaged the Quran and hadith to question Maududi’s “neopatriarchate.” They critiqued his views (e.g. that women were naturally inferior to men, or that they were unfit for political office) through alternative readings of Islamic history and theology. Chapter 7 (“The Mundane: Critique as Social-Cultural Practice”) seeks to locate critique at “the center of life for everyone, including ordinary sub- jects with no educational degrees” (179). Ahmad writes at length about Khan Abdul Ghaffar Khan (d. 1988), the anticolonial activist who led a massive movement against colonial domination, and whose following faced British brutality with nonviolence. The Khudai Khidmatgār movement he built was “a movement of critique” (195), Ahmad writes, composed of or- dinary men and women, peasants and the unlettered. The brief remainder of the chapter suggests that the proverbs which punctuate everyday life (for example, in the trope of the greedy mullah) also act as critiques. By the end of Religion as Critique it is difficult not to see critique na- scent in every declaration or action. This deflates the analytic power of the term—but perhaps that is one unstated aim of the project, to reveal critique as simply a part of life. Certainly the book displaces the exceptional West- ern claim to critique. Yet this trope of exposure—anthropology as cultural critique, the ethnographer’s gaze turned inward—also raises questions of its own. In this case, the paradigmatic account of critique (Western, sec- ular) has been exposed as actually being provincial. But the means of this exposure have not come from the alternative tradition of critique Ahmad elaborates. That is, Ahmad is not himself articulating an Islamic critique of Western critique. (Maududi serves as an “illustration” of Ahmad’s ar- gument; Maududi does not provide the argument itself.) In the first chap- ters (“Formulation”) he cites a wide literature that practices historicism, genealogy, archeology, and deconstruction in order to temper the universal claims of Western supremacists. The status of these latter critical practices however is not explored, as to whether they are in themselves sufficient to provincialize or at least de-weaponize Western critique. Put more directly: is there is a third language (of political anthropology, for example) by which Ahmad analytically mediates the encounter between rival traditions of cri- tique? And if there is such a language, and if it is historically, structurally, and institutionally related to one of the critical traditions it is mediating, then what is the status of the non-Western “illustration”? The aim of this revision of critique, Ahmad writes, is “genuinely dem- ocratic dialogue with different traditions” (xii). As much is signalled in its citational practices, which (for example) reference Talal Asad and Viveiros de Castro together in calling for “robust comparison” (14) between West- ern and Islamic notions of critique, and reference Maududi and Koselleck together in interpreting critique to be about judgment (203). No matter that Asad and de Castro or Maududi and Koselleck mean different things when using the same words; these citations express Ahmad’s commitment to a dialogic (rather than dialectical) mode in engaging differences. Yet because Ahmad does not himself explore what is variously entailed by “comparison” or “judgment” in these moments, such citations remain as- sertions gesturing to a dialogue to come. In this sense Religion as Critique is a thoroughly optimistic book. Whether such optimism is warranted might call for a third part to follow “Formulation” and “Illustration”: “Reckoning.” Basit Kareem IqbalPhD candidate, Department of Anthropologyand Program in Critical TheoryUniversity of California, Berkeley

e5034052The pandemic caused by the new coronavirus affected different sectors of society, among them, the school, with this, the school community had to reevaluate its forms of interaction and one of the strategies implemented was the development of emergency remote education, with the use of Digital Information and Communication Technologies (DICT). That said, this article aims to analyze the challenges and contributions of a training, carried out through emergency remote teaching, on the teaching of Spatial Geometry from the use of different technological tools. The training was carried out with twenty mathematics teachers from different regions of Brazil. The meetings and the execution of the activities were held between the months of May and June 2020, completely at a distance, organized in five synchronous meetings (Google Meet) and asynchronous (Google Classroom and Whatsapp). The research, with a qualitative approach, used as instruments for data collection: video recordings, activities developed with the GeoGebra software, as well as protocols of asynchronous activities. The results obtained through content analysis indicate contributions related to appropriation and technological deepening; professional development and collaborative networking. For future studies, it is intended to expand the workshop to new classes, including teachers from the early years of elementary school or in initial training and with students of different school levels.ResumoA pandemia provocada pelo novo coronavírus afetou diferentes setores da sociedade, dentre eles, a escola, com isso, a comunidade escolar precisou reavaliar suas formas de interação e uma das estratégias implementadas foi o desenvolvimento do ensino remoto emergencial, com a utilização de Tecnologias Digitais de Informação e Comunicação (TDIC). Isso posto, este artigo tem como objetivo analisar os desafios e as contribuições de uma formação, realizada por meio do ensino remoto emergencial, sobre o ensino de Geometria Espacial, a partir da utilização de diferentes ferramentas tecnológicas. A formação foi realizada com vinte professores de Matemática de regiões distintas do Brasil. Os encontros e a execução das atividades foram realizados entre os meses de maio e junho de 2020, completamente a distância, organizados em cinco encontros síncronos (Google Meet) e assíncronos (Google Classroom e Whatsapp). A pesquisa, com abordagem qualitativa, utilizou como instrumentos para a coleta de dados: videogravações, atividades desenvolvidas com o software GeoGebra, além de protocolos de atividades assíncronas. Os resultados, obtidos por meio da análise de conteúdo, indicam contribuições relacionadas com a apropriação e aprofundamento tecnológico, o desenvolvimento profissional e a formação de rede colaborativa. Para estudos futuros, pretende-se expandir a oficina para novas turmas, incluindo professores dos anos iniciais do Ensino Fundamental ou em formação inicial e com estudantes de diferentes níveis escolares.Palavras-chave: Ensino remoto, TDIC, Geometria Espacial, Formação docente.Keywords: Remote teaching, DICT, Spatial Geometry, Teacher Education.ReferencesALVES, Lynn. Educação remota: entre a ilusão e a realidade: Remote education: between illusion and reality / Educación remota: entre ilusión y realidad. Interfaces Científicas, Aracaju, v. 8, n. 3, p. 348-365, 2020.ARRUDA, Eucidio Pimenta. Educação remota emergencial: elementos para políticas públicas na educação brasileira em tempos de Covid-19. EmRede: Revista de Educação a Distância, Porto Alegre, v. 7, n. 1, p. 257-275, 2020.BENK, Polyana; SILVA, Sérgio Marconi da; FIGUEIREDO, Elisandra Bar de; SIPLE, Ivanete Zuchi. O Princípio de Cavalieri: numa abordagem apoiada pelas tecnologias atuais. 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Construção do conceito de covariação por estudantes do ensino fundamental em ambientes de múltiplas representações com suporte das tecnologias digitais. 275f. – Tese (Doutorado) – Universidade Federal do Ceará, Programa de Pós-graduação em Educação Brasileira, Fortaleza (CE), 2016.COSTA, Adriano Ribeiro da. A Educação a Distância no Brasil: Concepções, histórico e bases legais. Rios Eletrônica - Revista Científica da Faculdade Sete de Setembro. Paulo Afonso, BA, a. 11, n. 12, p. 59-74, 2017.GARRIDO, Yolanda Proenza; LEYVA, Luis Manuel Leyva. Pensamiento geométrico en los escolares primarios: un modelo didáctico para estimularlo. In: Congresso Internacional de Matemática e computação, 2005, Holguín. Anais eletrônicos... Holguín., 2005.GOMES, Luiz Fernando. EaD no Brasil: perspectivas e desafios. Avaliação (Campinas), Sorocaba, v. 18, n. 1, pág. 13-22. 2013. Disponível em: https://www.scielo.br/scielo.php?pid=S141440772013000100002script=sci_arttexttlng=pt. 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This study aimed to examine the implementation pattern of the constructivist theory in limited face-to-face learning (PTMT). The method used was descriptive qualitative with the subject of teachers in the Malang City area. Data was collected by using a survey distributed online through Google Forms. The results showed that the implementation pattern ofconstructivist theory in limited face-to-face learning (PTMT) was carried out through 5 (five) base of learning implementation, namely the application of problem-based learning, the application of project-based learning, the use of digital-based teaching materials and media, the application of psychosocial learning and contextuallearning. Teachers carried out limited face-to-face learning by applying constructivist theory massively and gradually, starting from planning, the process of learning activities, and learning evaluation. In addition to the use of media and 5M learning models in this study, the application of constructivist theory in PTMT learning aimed to help students become more active and teachers as moderators be more innovative. Learning process carried out at the elementary school level was only 50 percent attendance at the maximum. The implementation of student-centered learning showed 45% was very good, 50% was good, 2.5% was good, 2.5% was not good. The results showed that the inhibiting factor for student-centered implementation was the limited duration of time in learning. On the other hand, there were also restrictions on interactions carried out in the classroom so that teachers experienced a decline in exploring the learning process. Keywords: constructivism theory. limited face-to-face learning, elementary school. References: Adiyono, A. 2021. Implementasi Pembelajaran: Peluang dan Tantangan Pembelajaran Tatap Muka Bagi Siswa Sekolah Dasar di Muara Komam. 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soumission à Episciences This paper is dedicated to the implementation of a law of mechanical behavior in the finite element software Cast3M using an open source code generator named Mfront. To do so, an elastoplastic behaviour model has been chosen from existing laws in the literature. Following an implicit discretization, a hardware library corresponding to the isotropic and kinematic strain-hardening model is generated using Mfront. The UMAT computer interface is used to build the library in Cast3M. A validation of the approach has been carried out by comparing the numerical results obtained with the generated hardware library and the equivalent pre-existing library in Cast3M. Simulations in the case of a tensile bar and a perforated plate show almost identical results Ce papier est dédié à l’implantation d’une loi de comportement mécanique dans le logiciel éléments finis Cast3M à l’aide d’un générateur de code open source nommé Mfront. Pour ce faire, un modèle de comportement élasto-plastique a été choisi à partir des lois existantes dans la littérature. Suivant une discrétisation implicite, une bibliothèque matérielle correspondant au modèle de CHABOCHE à écrouissage isotrope et cinématique non linéaire est générée grâce à Mfront. L’interface informatique UMAT est utilisée pour construire la bibliothèque dans Cast3M. Une validation de l’approche a été menée en comparant les résultats numériques obtenus entre la bibliothèque matérielle générée et la bibliothèque équivalente préexistante dans Cast3M. Les simulations dans le cas d’une barre en traction et une plaque trouée montrent des résultats quasi identiques

Summary The canopy light extinction coefficient (k) is defined as the exponential decline in the amount of light passing through the leaf layers as a function of leaf area index (LAI). This definition is standard in oil palm breeding trials and models of canopy photosynthesis, where k is sometimes assumed to have a fixed value. The present experiment aims to validate the alleged constancy of k. Therefore, k was inferred from the fractional transmission of photosynthetically active radiation (PAR) and LAI, as obtained from dura x pisifera test crosses of Nigeria and Ghana pisifera origins. The palms were planted at two densities (135 and 160 palms ha−1) in North Sumatra in 2010. At the age of 7.5 years after planting, the area of newly opened leaves approached a maximum. Transmission of PAR remained very low and was only weakly related to k. By contrast, LAI exerted a strong negative effect on k, which generated, under both densities, considerable differences in k between both origins and among pisifera within an origin. The assumption of applying a fixed k value for a certain genotype or palm density, as obtained during leaf expansion at closed canopy, may therefore not be realistic. The present study suggests that the relationship of k with LAI over time merits further investigation, starting just before canopy closure.

AbstractWe report the three-dimensional (3D) mapping of polycyclic aromatic hydrocarbons (PAHs), soot, and hydroxyl radicals (OH) in ethylene/air diffusion flames. A structured illumination-based frequency recognition algorithm for multiple exposures (FRAME) approach is combined with sample translation to intersect the flame in several two-dimensional planes. The FRAME technique has been used for recording a snapshot of multiple species on a single camera. It relies on extracting the amplitude of spatial modulation of two or more probed species encoded on a single sub-image. Here, the FRAME technique is first applied for simultaneous imaging of PAH by laser-induced fluorescence (PAH-LIF) and soot by laser-induced incandescence (LII). Sequentially, it is employed for simultaneous mapping of OH-LIF and soot-LII. The LII signal is converted to absolute soot volume fraction (fv) maps using a line-of-sight light extinction measurement. Finally, we have demonstrated the approach for layer-wise 2D imaging of soot volume fraction and averaged 3D mapping of multiple species.

Abstract Leaf or plant area index (LAI, PAI) information is frequently used to describe vegetation structure in environmental science. While field measurements are time-consuming and do not scale to landscapes, model-based air- or space-borne remote-sensing methods have been used for many years for area-wide monitoring. As of 2019, NASA's Global Ecosystem Dynamics Investigation (GEDI) mission delivers a point-based LAI product with 25 m footprints and periodical repetition. This opens up new possibilities in integrating GEDI as frequently generated training samples with high resolution (spectral) sensors. However, the foreseeable duration of the system installed on the ISS is limited. In this study we want to test the potential of GEDI for regional comprehensive LAI estimations throughout the year with a focus on its usability beyond the lifespan of the GEDI mission. We study the landscape of Hesse, Germany, with its pronounced seasonal changes. Assuming a relationship between GEDI's PAI and Sentinel-1 and -2 data, we used a Random Forest approach together with spatial variable selection to make predictions for new Sentinel scenes. The model was trained with two years of GEDI PAI data and validated against a third year to provide a robust and temporally independent model validation. This ensures the applicability of the validation for years outside the training period, reaching a total RMSE of 1.12. Predictions for the test year showed the expected seasonal and spatial patterns indicated by RMSE values ranging between 0.75 and 1.44, depending on the land cover class. The overall prediction performance shows good agreement with the test data set of the independent year which supports our assumption that the usage of GEDI's PAI beyond the mission lifespan is feasible for regional studies.

Medical image resolution has been a serious limitation in plaque progression research. A modeling approach combining intravascular ultrasound (IVUS) and optical coherence tomography (OCT) was introduced and patient follow-up IVUS and OCT data were acquired to construct three-dimensional (3D) coronary models for plaque progression investigations. Baseline and follow-up in vivo IVUS and OCT coronary plaque data were acquired from one patient with 105 matched slices selected for model construction. 3D fluid–structure interaction (FSI) models based on IVUS and OCT data (denoted as IVUS + OCT model) were constructed to obtain stress/strain and wall shear stress (WSS) for plaque progression prediction. IVUS-based IVUS50 and IVUS200 models were constructed for comparison with cap thickness set as 50 and 200 μm, respectively. Lumen area increase (LAI), plaque area increase (PAI), and plaque burden increase (PBI) were chosen to measure plaque progression. The least squares support vector machine (LS-SVM) method was employed for plaque progression prediction using 19 risk factors. For IVUS + OCT model with LAI, PAI, and PBI, the best single predictor was plaque strain, local plaque stress, and minimal cap thickness, with prediction accuracy as 0.766, 0.838, and 0.890, respectively; the prediction accuracy using best combinations of 19 factors was 0.911, 0.881, and 0.905, respectively. Compared to IVUS + OCT model, IVUS50, and IVUS200 models had errors ranging from 1% to 66.5% in quantifying cap thickness, stress, strain and prediction accuracies. WSS showed relatively lower prediction accuracy compared to other predictors in all nine prediction studies.