Literatura científica selecionada sobre o tema "Antiviraux – composition chimique"
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Artigos de revistas sobre o assunto "Antiviraux – composition chimique"
Tine, Yoro, Moussa Diop, Idrissa Ndoye, Alioune Diallo e Alassane Wele. "Revue bibliographique sur la composition chimique et les activités biologiques de Guiera senegalensis J.F. Gmel. (Combretaceae)". International Journal of Biological and Chemical Sciences 13, n.º 7 (13 de fevereiro de 2020): 3449–62. http://dx.doi.org/10.4314/ijbcs.v13i7.37.
Texto completo da fonteOjezele, M. O. "Microbiome: pharmacokinetics, pharmacodynamics and drug/xenobiotic interactions". African Journal of Clinical and Experimental Microbiology 21, n.º 2 (17 de fevereiro de 2020): 78–87. http://dx.doi.org/10.4314/ajcem.v21i2.1.
Texto completo da fonteTeses / dissertações sobre o assunto "Antiviraux – composition chimique"
Respaud, Marie-José. "Etude phytochimique et évaluation d'activités biologiques de choisya ternata kunth (Rutaceae)". Toulouse, INPT, 1995. http://www.theses.fr/1995INPT043G.
Texto completo da fonteNakashima, Tomoe. "Etude phytochimique, évaluation des activités antifongiques et antivirales de trois verbenaceae : Lippia alba N.E.Brown, Lippia multiflora Mold. Citharexylum myrianthum Cham". Toulouse, INPT, 1993. http://www.theses.fr/1993INPT045G.
Texto completo da fonteHaslin, Camille. "Composition chimique, structure et évaluation des activités antivirales des polysaccharides pariétaux de l'algue méditerranéenne introduite Asparagopsis armata (Bonnemaisoniales) et de quatre Nemaliales". Aix-Marseille 1, 2000. http://www.theses.fr/2000AIX11003.
Texto completo da fonteMathieu, Thomas. "Etude de deux ANPs Antiviraux : caractéristiques physico-chimiques du LAVR-289 et formulations innovantes du Ténofovir". Electronic Thesis or Diss., Orléans, 2024. http://www.theses.fr/2024ORLE1021.
Texto completo da fonteThis thesis is part of one of the stages in the preclinical development of a drug candidate, which consists in determining various physico-chemical characteristics of the compound and exploring its formulation. The molecule in preclinical phase is LAVR-289, a novel broad-spectrum antiviral belonging to the acyclonucleoside phosphonate family, developed in prodrug form.We began by determining various parameters of LAVR-289 such as pKa, Log P and critical aggregation concentration by UV-visible spectrophotometry, reversed phase liquid chromatography and spectrofluorimetry, respectively. We also developed a HPLC-UV analytical method to determine the purity of LAVR-289 synthesis batches. This analytical method was used to determine the chemical stability of this molecule with respect to solvents and pH, as well as its plasma enzymatic stability. LC-HR-MS analyses were used to obtain the structure of degradation products and some metabolites. In the second part, we have synthesised new polymeric nanocarriers based on molecular imprinting technology for the controlled release of phosphonate acyclonucleosides. This exploratory study was carried out on Tenofovir, an antiviral used in the treatment of HIV and HBV infections. These nanomaterials were developed by precipitation polymerisation or by creating core-shell systems after surface derivatisation of biodegradable and biocompatible nanoparticles synthesised in the laboratory. These polymers were created from monomers derived from the functionalisation of pyrimidine bases. These materials showed slower temperature-dependent release kinetics of Tenofovir than the no imprinted form
Techer, Sophie. "Criblage d’activités biologiques de plantes endémiques ou indigènes de La Réunion - Recherche de molécules antivirales ciblant le virus du chikungunya". Thesis, La Réunion, 2013. http://www.theses.fr/2013LARE0014/document.
Texto completo da fonteThe aims of this PhD work were to identify plants and/or molecules with cytotoxic, antioxidant, anti-inflammatory or antiviral (chikungunya virus , CHIKV) activities in order to find therapeutic alternatives towards oxidative stress and inflammation, mechanisms involved in chronic noncommunicable diseases (diabetes, obesity ...), and chikungunya disease, reemerging vector-borne disease. The first part of this work presents the results obtained from a biological screening carried out on a selection of eighteen endemic and indigenous plants of La Réunion. The targeted activities were cytotoxicity on a human cell line (THP-1), antioxidant activities evaluated using an in cellulo hemolysis assay and four chemical tests (TEAC / DPPH / FRAP / ORAC) together with an evaluation of the content of phenolic compounds (FOLIN test) and anti-inflammatory activity tested in murine macrophages (RAW cells-BlueTM). The results allowed to highlight activities of different extracts in particular : cytotoxic for Carissa spinarum, antioxidant for Dryopteris wallichiana and Agarista buxifolia and anti-inflammatory for Stillingia lineata and Indigofera ammoxylum.The second part of this work is devoted to the phytochemical study of Stillingia lineata, an indigenous species of La Réunion chosen because of the results obtained in this preliminary biological screening and those carried out in Phytochik programme. Bioassay-guided fractionation performed on Vero cells (green monkey kidney cells Cercopithecus aethiops) infected with CHIKV led to the isolation of three rare macrocycle-type diterpenes called tonantzitlolone and a new pimarane. The 4'-acetoxytonantzitlolone was identified as a candidate molecule against CHIKV (EC50 = 7 μM). Structure-activity relationships have been defined, the presence of an oxygenated group on the side chain of tonantzitlolones seems to play an important role in the antiviral response of the diterpene skeleton