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Teses / dissertações sobre o tema "Animal models"

Autor: Grafiati

Publicado: 4 de junho de 2021

Última modificação: 25 de julho de 2025

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1

YalcÌ§in, Biannaz. "QTL mapping in animal models." Thesis, University of Oxford, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.410716.

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2

Mazzola, Carmen. "Neuropharmacology and Behaviural Animal Models." Thesis, Universita' degli Studi di Catania, 2011. http://hdl.handle.net/10761/93.

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Lo studio delle patologie umane richiede spesso l'ausilio di sperimentazioni animali. Generalmente i dati ottenuti in questi modelli permettono di ampliare le conoscenze sui meccanismi eziologici e sul trattamento delle patologie. Perche' un modello sperimentale sia considerato attendibile, deve avere specifici requisiti: face validity, construct validity and predictive validity. Rispettare tali criteri e' di enorme importanza per la ricerca in ambito fisiologico e farmacologico.<br>The study of human disease often involves performing physiological and pharmacological experiments in animal mo

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3

Klingström, Jonas. "Hantaviruses : animal models, immunology and pathogenesis /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-071-0/.

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4

Thomas, Kurt Florian Patrick. "Animal models of retroviral neurological diseases." Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=39882.

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The neuropathogenicity of two retroviruses was investigated. The human immunodeficiency virus, in addition to its profound effect on the immune system, also causes degenerative changes in the brain, the spinal cord and peripheral nerves. In order to elucidate how it affects the nervous system, transgenic mice were generated that express the entire HIV genome in neurons in the anterior thalamus and in the anterior horn of the spinal cord, and examined clinically, neuropsychologically, electrophysiologically and histologically. Animals developed a neurological syndrome characterized by hypoactiv

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5

Lydall, Emma Sian. "Palatability and animal models of schizophrenia." Thesis, Cardiff University, 2011. http://orca.cf.ac.uk/55071/.

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Schizophrenia is one of the most serious mental disorders of humankind. It affects about 1% of the population worldwide and has devastating consequences, including suicide in 10% of sufferers (e.g. Lewis & Lieberman, 2000). Schizophrenia also has serious social impact with sufferers accounting for more than one third of the homeless population in western society (Folsom & Jeste, 2002).

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6

Warren, Nicholas David. "Some stochastic models for animal territories." Thesis, University of Sheffield, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312289.

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7

Jusof, Felicita Fedelis. "Tryptophan-catabolising enzymes in animal models." Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/13697.

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The first and rate-limiting step of the kynurenine pathway is the metabolism of tryptophan (Trp) to N-formylkynurenine, which is then rapidly converted to kynurenine. This initial step can be catalysed by three enzymes, tryptophan 2,3-dioxygenase (TDO), indoleamine 2, 3-dioxygenase-1 (IDO1) and the most recently discovered, IDO2. In adult mammals, TDO is expressed constitutively in the liver and is involved in the global regulation of tryptophan. IDO1 expression is mainly induced in various tissues during inflammatory conditions. IDO2, detected in the adult liver, may play a role in inflammati

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8

Zemp, Franz Joseph, and University of Lethbridge Faculty of Arts and Science. "The bystander effect : animal and plant models." Thesis, Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2008, 2008. http://hdl.handle.net/10133/685.

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Bystander effects are traditionally known as a phenomenon whereby unexposed cells exhibit the molecular symptoms of stress exposure when adjacent or nearby cells are traversed by ionizing radiation. However, the realm of bystander effects can be expanded to include any systemic changes to cellular homeostasis in response to a number of biotic or abiotic stresses, in any molecular system. This thesis encompasses three independent experiments looking at bystander and bystander-like responses in both plant and animal models. In plants, an investigation into the regulation of small RNAs has given

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9

Birrell, Mark Andrew. "Characterisation of animal models of airway eosinophilia." Thesis, Imperial College London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408172.

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10

Nwosu, V. U. "Peroxisome enzymes in animal models of obesity." Thesis, University of Wolverhampton, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.380662.

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11

Degrassi, Anna. "MRI studies of animal models for osteoarthritis." Thesis, University of Cambridge, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621774.

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12

Allcroft, David John. "Statistical models for short-term animal behaviour." Thesis, University of Edinburgh, 2001. http://hdl.handle.net/1842/11132.

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This thesis aims to identify appropriate methods for the modelling of animal behaviour data, and in the wider context, any time series of categorical data. We make extensive use of a large dataset of cow feeding behaviour, consisting of full feeding records for a number of cows over one month, the data taking the form of binary time series, i.e. feeding/non-feeding periods. After initial exploratory data analysis, we go on to investigate three classes of model: latent Gaussian, hidden Markov and semi-Markov. The latent Gaussian model assumes the binary data occur from the thresholding of an un

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13

Hitchen, Barry. "Behavioural evaluation of animal models of diabetes." Thesis, Ulster University, 2017. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.744769.

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Diabetes is considered as a prominent threat to the worldwide population, and if left untreated may result in a number of severe complications, cognitive deterioration, and death. For the most prevalent form of the disease, type 2 diabetes, the main contributing factors to the development of the disease is being overweight and obese. There are a number of mediating factors regarding the relationship between excessive weight gain and subsequent development of diabetes, the most widely supported of which is the typical eating behaviours of the individual. While the physiological characteristics

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14

Atanasova, Nina A. "Animal Models and the Unity of Neuroscience." University of Cincinnati / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1406820028.

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15

Bierman, Stijn Martinus. "Spatio-temporal models in animal population dynamics." Thesis, University of Aberdeen, 2004. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU195633.

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Population dynamics is the study of how and why populations of animals change in distribution and abundance. Thus, the aims of the science of population dynamics are twofold: to document the empirical patterns of population distribution and change, and to determine the mechanisms underlying those observed patterns. Population dynamics data typically have rich and complex spatio-temporal patterns. Modern and flexible statistical methods are needed to describe these patterns, and for the sound estimation of parameters in realistic mathematical models of spatio-temporal population dynamics. Of pa

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16

Lai, Edwin W. "Molecular characterization of animal models of pheochromocytoma." Connect to Electronic Thesis (CONTENTdm), 2009. http://worldcat.org/oclc/454140444/viewonline.

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17

Talbot, Nicola A. "Obesity, inflammation and insulin resistance in skeletal muscle." Thesis, Royal Veterinary College (University of London), 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.618327.

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18

Schofield, Matthew R., and n/a. "Hierarchical capture-recapture models." University of Otago. Department of Mathematics & Statistics, 2007. http://adt.otago.ac.nz./public/adt-NZDU20080129.161029.

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A defining feature of capture-recapture is missing data due to imperfect detection of individuals. The standard approach used to deal with the missing data is to integrate (or sum) over all the possible unknown values. The missing data is completely removed and the resulting likelihood is in terms of the observed data. The problem with this approach is that often biologically unnatural parameters are chosen to make the integration (summation) tractable. A related consequence is that latent variables of interest, such as the population size and the number of births are only available as derived

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19

Glennie, Richard. "Incorporating animal movement with distance sampling and spatial capture-recapture." Thesis, University of St Andrews, 2018. http://hdl.handle.net/10023/16467.

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Distance sampling and spatial capture-recapture are statistical methods to estimate the number of animals in a wild population based on encounters between these animals and scientific detectors. Both methods estimate the probability an animal is detected during a survey, but do not explicitly model animal movement. The primary challenge is that animal movement in these surveys is unobserved; one must average over all possible paths each animal could have travelled during the survey. In this thesis, a general statistical model, with distance sampling and spatial capture-recapture as special cas

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20

Telkes, Ilknur. "Phase Validation Of Neurotoxic Animal Models Of Parkinson." Master's thesis, METU, 2012. http://etd.lib.metu.edu.tr/upload/12614866/index.pdf.

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Parkinson&rsquo<br>s disease (PD) is characterized by the progressive loss of dopaminergic nigral neurons and striatal dopamine resulting in serious motor deficits but also some non-motor anomalies. Animal models of human neurodegenerative diseases are essential for better understanding their pathogenesis and developing efficient therapeutic tools. There are many different PD models, however, none of them is fully reproducing all the symptoms of the disease. In addition, different investigators use different behavioral measures which makes even more difficult to compare and evaluate the result

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21

Brenner, Eiliv. "Glutamate related metabolism in animal models of schizophrenia." Doctoral thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for nevromedisin, 2011. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-13875.

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Schizophrenia is a clinical syndrome of variable psychopathology, which involves thought, perception, emotion, movement and behavior. The cumulative effect of the illness is always severe and usually long lasting. Epidemiologic studies indicate that the lifetime expectancy is 0.5-1% worldwide. The etiology and pathophysiology of schizophrenia are unknown. The two predominant pathophysiological hypotheses of schizophrenia are the dopamine hypothesis and the glutamate hypothesis. The former hypothesis states that dopamine neurotransmission is hyperactive in schizophrenia, the latter – that there

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22

Duncan, Warwick John, and n/a. "Sheep mandibular animal models for dental implantology research." University of Otago. School of Dentistry, 2005. http://adt.otago.ac.nz./public/adt-NZDU20060707.144214.

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This inquiry investigated the suitability of the jaw of domestic sheep as an animal model for dental implantology research. Initially, parameters for osseous healing of critical size defects (CSD) in the sheep mandible were established. Pilot studies were conducted using machined-surface implants and a surgical protocol established for dental implant placement in ovine mandibular sites. Subsequent experiments considered the utility of this animal model for examination of techniques designed to enhance osseointegration. Hydroxyapatite-coated implants were compared with titanium plasma-sprayed (

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23

Nilsson, Tatjana. "Amyloid precursor protein: cellular studies and animal models /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-832-0/.

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24

Pålsson, Erik. "Cognitive function studied in animal models of schizophrenia /." Göteborg : Dept. of Pharmacology, Institute of Neuroscience and Physiology, 2006. http://hdl.handle.net/2077/775.

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25

Arlinde, Christina. "Gene expression profiling in animal models of alcoholism /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-133-4/.

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26

Nordquist, Niklas. "Genetic Studies of Rheumatoid Arthritis using Animal Models." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2001. http://publications.uu.se/theses/91-554-5117-9/.

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27

Rostami, Elham. "Traumatic brain injury in humans and animal models." Doctoral thesis, Stockholm : Reproprint AB, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-212088.

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28

Ingram, E. "Glial glutamate transporters in animal models of epilepsy." Thesis, University of Cambridge, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.604933.

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The two glial transporters, GLAST (<SUB>L</SUB>-glutamate/L-aspartate transporter) and GLT-1 (<SUB>L</SUB>-glutamate transporter), are critical in regulating extracellular glutamate levels, being responsible for the majority of glutamate reuptake. The present study investigated GLAST and GLT-1 mRNA and protein levels in two animal models of inherited epilepsy: the EL (epileptic) mouse, a convulsive seizure model, and the GAERS (genetic absence epilepsy rat from Strasbourg) rat, a model of absence epilepsy. Additionally, tissue glutamate concentrations were determined in these animals by high p

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29

Gilder, Michael Frederick James. "Molecular investigations in animal models of Huntington's disease." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325046.

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30

Deiana, Serena. "Animal models for novel drug treatments of tauopathies." Thesis, University of Aberdeen, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.446226.

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A transgenic animal model in which tau protein aggregation is expected to produce behavioural symptoms similar to those observed in certain tauopathies in humans has been examined in this thesis. The transgenic mouse lines, when tested in a heterozygous genetic background, showed no cognitive deficit although non-associative learning was impaired. Fine motor learning and motor coordination, however, were severely compromised suggesting disruption of cerebellar and/or basal ganglia function. This model can be used to test tau aggregation inhibitors, that may be effective in preventing, or even

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31

Matthews, Keith D. "Animal models of affective psychopathology : depression and reward." Thesis, University of Aberdeen, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.319857.

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One approach to the clinical problem of defining the neural substrates of human depressive disorders is to model discrete aspects of affective psychopathology in animals. Two major methodological problems have hindered the development of valid animals models of depression. First, individual responses to the manipulations commonly used to model depression are highly variable. Second, reliable and valid measures of hedonic state remain elusive. This thesis describes experimental work which addresses these methodological concerns. Selective breeding based on individual responses to cholinergic ch

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32

Devadasu, Venkat Ratnam. "Evaluation of antioxidants encapsulated nanoparticles in animal models." Thesis, University of Strathclyde, 2011. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=16829.

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33

Selvan, Nithya. "Reductionist animal models to probe protein O-GlcNAcylation." Thesis, University of Dundee, 2015. https://discovery.dundee.ac.uk/en/studentTheses/6034adb4-fc6a-4c47-ade6-74e0b18d4297.

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Protein O-GlcNAcylation is a reversible type of glycosylation of serine and threonine residues of nucleocytoplasmic proteins occurring in all animals examined to date. Its installation on protein substrates is carried out by O-GlcNAc transferase (OGT), and its removal by O-GlcNAc hydrolase (O-GlcNAcase or OGA). A range of proteomics studies have suggested that over a thousand intracellular proteins are O-GlcNAc modified. However, little is known of the role of O-GlcNAc on these proteins. In a search for a reductionist model with a small proteome to dissect the general global mechanisms of prot

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34

Bicer, Sabahattin. "Efficacy/toxicity studies of amiodarone in animal models /." The Ohio State University, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=osu1486546889383936.

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35

Lopes, Vanessa Ferreira. "Caracterização funcional das diferentes linhagens de modelos murinos para distrofias musculares." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/87/87131/tde-04052011-150431/.

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As distrofias musculares constituem um grupo heterogêneo de doenças genéticas, caracterizadas por uma degeneração progressiva e irreversível dos músculos. Modelos murinos distróficos, como o mdx, SJL/J, Largemyd e Lama2dy-2J/J, são ferramentas importantes para o estudo destas doenças. O objetivo deste trabalho consistiu em estabelecer parâmetros de avaliação funcional que visem a sua utilização para elucidar os benefícios clínicos de futuras terapias. Para tanto, foram avaliadas as quatro linhagens distróficas, em diferentes idades, e comparadas a controle normal. Os testes padronizados consi

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36

Pereira, Danilo Florentino. "Metodologia para estimativa de bem-estar de matrizes de frango de corte utilizando monitoramento digital e construção de modelos de simulação." [s.n.], 2003. http://repositorio.unicamp.br/jspui/handle/REPOSIP/257219.

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Orientador: Irenilza de Alencar Naas<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Engenharia Agricola<br>Made available in DSpace on 2018-08-05T13:34:42Z (GMT). No. of bitstreams: 1 Pereira_DaniloFlorentino_D.pdf: 4613464 bytes, checksum: f69737da451ffc0d2ceecda7fcdacd9b (MD5) Previous issue date: 2003<br>Resumo: Esse trabalho propôs o uso de ferramentas de precisão para o monitoramento de matrizes pesadas que sirvam para a coleta de dados comportamentais que contribuem para a predição de bem-estar. Foram conduzidos dois experimentos em câmara climática onde se obser

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37

Gonçalves, Ana Sofia Ribeiro. "Validação do modelo de ansiedade Light / Dark Exploration Test em ratos Wistar." Master's thesis, Instituto Superior de Psicologia Aplicada, 2007. http://hdl.handle.net/10400.12/558.

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Dissertação de Mestrado em Etologia<br>Os modelos elevated plus-maze e light/dark são amplamente utilizados no estudo de compostos ansiolíticos e dos mecanismos neurobiológicos de ansiedade. O elevated plus-maze (EPM) e o open-field (OF) são testes validados para avaliação da ansiedade em ratos e ratinhos. O teste ligh/dark (LD) também é utilizado nos modelos de ansiedade, no entanto, só foi validado para modelos em ratinhos. Para validar o teste LD como um modelo de ansiedade em ratos avaliaram-se os parâmetros: validade construtiva, validade exterior e validade preditiva. Estes parâmetros fo

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38

Van, Eeden Willem Daniel. "Human and animal classification using Doppler radar." Diss., University of Pretoria, 2005. http://hdl.handle.net/2263/66252.

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South Africa is currently struggling to deal with a significant poaching and livestock theft problem. This work is concerned with the detection and classification of ground based targets using radar micro- Doppler signatures to aid in the monitoring of borders, nature reserves and farmlands. The research starts of by investigating the state of the art of ground target classification. Different radar systems are investigated with respect to their ability to classify targets at different operating frequencies. Finally, a Gaussian Mixture Model Hidden Markov Model based (GMM-HMM) classification a

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39

Cartón, García Fernando. "Myosin VB in intestinal pathogenesis." Doctoral thesis, Universitat Autònoma de Barcelona, 2017. http://hdl.handle.net/10803/458251.

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Miosina VB es una proteína que actúa como un motor molecular usando la energía del ATP para moverse a lo largo de filamentos de actina. Participa en el trafico intracelular de endosomas de reciclaje en la parte subapical de células polarizadas y no polarizadas. Su expresión es muy abundante en el intestino donde participa en el establecimiento y mantenimiento de la polaridad de los enterocitos. Mutaciones en MYO5B causan la enfermedad de inclusión de microvellosidades, in raro trastorno congénito que afecta a las células epiteliales del intestino cursando con diarrea acuosa persistente que sue

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40

Groppo, Mônica Feresini 1965. "Efeito de uma membrana de PCL impregnada com hidroxiapatita em defeito ósseo induzido na calvária de ratos." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/288467.

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Orientador: Ana Cláudia Rossi<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba<br>Made available in DSpace on 2018-08-26T07:37:41Z (GMT). No. of bitstreams: 1 Groppo_MonicaFeresini_M.pdf: 1793041 bytes, checksum: 85a537401a5b84975a441824072b9e89 (MD5) Previous issue date: 2014<br>Resumo: O objetivo do presente estudo foi observar o efeito de uma membrana de nanofibras poliméricas a base de poli-epsilon-caprolactona (PCL), impregnadas ou não com hidroxiapatita (HA), na reparação óssea em defeitos críticos produzidos artificialmente na calvá

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41

Lariviere, William R. "The bee venom test : a new tonic-pain test." Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=23405.

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The present study describes a new test of tonic pain in rats which can be used as an animal model of persistent pain. In the first experiment, the response to subcutaneous injection of various doses of bee venom into the hind paw of the rat was quantified. The second experiment investigated the effect of morphine and aspirin on the response to an intermediate dose of bee venom. Finally, the third experiment examined the response to concurrent injections of bee venom and formalin. Subcutaneous injection of bee venom produced local inflammation, marked edema, and tonic pain responses. Increasing

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42

Salas, Torras Anna. "Desarrollo de modelos celulares y animales para el estudio de terapia génica no viral anti-angiogénica en retina." Doctoral thesis, Universitat Autònoma de Barcelona, 2017. http://hdl.handle.net/10803/456676.

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La degeneración macular asociada a la edad (DMAE) y la retinopatía diabética (RD) pertenecen a un grupo de degeneraciones de retina con etiología compleja, influenciadas tanto por factores genéticos como ambientales. Aunque sus orígenes son distintos y sus mecanismos moleculares son complejos, ambas se caracterizan por una neurodegeneración progresiva con presencia de apoptosis en la retina, activación glial, estrés oxidativo y la aparición de neovascularización en sus fases más avanzadas. Estas dos enfermedades son las

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43

Peleg-Raibstein, Daria. "Animal models of schizophrenia: a behavioral and neurochemical investigation /." Zürich : ETH, 2006. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=16488.

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44

Thomas, Róisín Clare. "Nociceptin/orphanin FQ system and animal models of sepsis." Thesis, University of Leicester, 2016. http://hdl.handle.net/2381/38496.

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The nociceptin receptor (NOP) and its ligand nociceptin/orphanin FQ (N/OFQ) have been shown to exert a modulatory effect on immune cells during sepsis. We evaluated the suitability of three different experimental animal models for studying changes in the nociceptin system; lipopolysaccharide (LPS)-induced sepsis, faecal slurry-induced sepsis and caecal ligation and puncture-induced sepsis. Methods. LPS-induced sepsis: C57BL/6mice BALB/c mice and Wistar rats were inoculated with different doses of LPS with or without a nociceptin receptor antagonist (UFP-101 or SB-612111). Fecal slurry-induced

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45

Samaranayaka, Ari, and n/a. "Environmental stochasticity and density dependence in animal population models." University of Otago. Department of Mathematics & Statistics, 2006. http://adt.otago.ac.nz./public/adt-NZDU20060907.114616.

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Biological management of populations plays an indispensable role in all areas of population biology. In deciding between possible management options, one of the most important pieces of information required by population managers is the likely population status under possible management actions. Population dynamic models are the basic tool used in deriving this information. These models elucidate the complex processes underlying the population dynamics, and address the possible consequences/merits of management actions. These models are needed to guide the population towards desired/chosen man

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46

Haile, Melles. "Studies on new tuberculosis vaccine candidates in animal models /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-327-2/.

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47

Lindberg, Julia. "Exploring Brain Gene Expression i Animal Models of Behaviour." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8177.

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Bickerdike, Michael John. "CCK/5-HT interactions in animal models of anxiety." Thesis, University of Nottingham, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241150.

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Hough, Sally Jane. "Development of animal models to investigate drug-induced toxicity." Thesis, University of Liverpool, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266265.

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