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Scavée, V., S. Theys e J.-C. Schoevaerdts. "Surgery of varicose veins with transilluminated powered mini-phlebectomy: clinical experience". Phlebology: The Journal of Venous Disease 18, n.º 2 (1 de junho de 2003): 97–99. http://dx.doi.org/10.1258/026835503321895415.
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The authors report their experience with a new surgical technique, the transilluminated powered mini-phlebectomy (Trivex' System, Smith & Nephew Inc, Andover, USA), to remove primary varicose veins. There were 70 patients, 50 women and 20 men, with a mean age of 52 ± 9 years. The average operating time was 56 ± 8 min (range 30–75 min). The mean number of incisions was five (range 2–8). The postoperative pain, cosmetic scores and all complications were evaluated prospectively.
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Erdemir, Ebru Olgun, Abdulkadir Şengün e Mustafa Ülker. "Cytotoxicity of Mouthrinses on Epithelial Cells by Micronucleus Test". European Journal of Dentistry 01, n.º 02 (abril de 2007): 080–85. http://dx.doi.org/10.1055/s-0039-1698318.
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ABSTRACTObjectives: To determine the cytotoxicity of three commercial mouthrinses Klorhex, Andorex and Tanflex on buccal epithelial cells using micronucleus (MN) test.Materials and Methods: 28 patients with aged 16-24 undergone three mouthrinses’ application were analyzed before and after one week exposure. Physiologic saline was used for the control group. The MN incidence was scored in the buccal epithelial of each participants. The difference in pre- and posttreatment after one week incidence of MN and plaque (PI) and gingival indices (GI) was compared by non-parametric statistical tests.Results: The micronuclei incidence increased in Klorhex, Tanflex and Andorex groups after exposure to mouth rinses (P<.05). But when compared with the control group, there was not any difference between Andorex and control group (P>.05). In the other study groups, MN incidence was significantly increased after 7 days treatment (P<.05). GI scores of all groups were decreased significantly (P<.05). PI scores were decreased only in the Klorhex group (P<.05).Conclusions: Our primary findings support the presence of possible cytotoxic effects of the mouthrinses on gingival epithelial cells. (Eur J Dent 2007;2:80-85)
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Wentzel, Jeanette, Cory Gall, Mark Bourn, Juan De Beer, Ferreira du Plessis e Geoffrey T. Fosgate. "Carnivore Detection at the Domestic/Wildlife Interface within Mpumalanga Province, South Africa". Animals 11, n.º 9 (29 de agosto de 2021): 2535. http://dx.doi.org/10.3390/ani11092535.
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South African protected areas account for 8% of the total landmass according to World Bank indicators. Effective conservation of biodiversity in protected areas requires the development of specific reserve management objectives addressing species and disease management. The primary objective of the current study was to identify predictors of carnivore detection in an effort to inform carnivore species management plans on Andover and Manyeleti nature reserves in South Africa. A limited number of camera traps were placed randomly using a grid system. Species detection data were analysed using mixed-effects logistic regression and Spearman’s correlation coefficients. Deterministic inverse distance weighted distribution maps were used to describe the spatial distribution of carnivore species. Camera traps identified similar species as traditional call-up surveys during the study and would be useful as an adjunct census method. Carnivore detection was associated with several variables, including the presence of specific prey species. The measured intra-and interspecies interactions suggested the risk of disease transmission among species, and vaccination for prevalent diseases should be considered to manage this risk.
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Gildea, Spike, e Doris Payne. "Is Greenberg's "Macro-Carib" viable?" Boletim do Museu Paraense Emílio Goeldi. Ciências Humanas 2, n.º 2 (agosto de 2007): 19–72. http://dx.doi.org/10.1590/s1981-81222007000200003.
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In his landmark work Language in the Americas, Greenberg (1987) proposed that Macro-Carib was one of the major low-level stocks of South America, which together with Macro-Panoan and Macro-Ge-Bororo were claimed to comprise the putative Ge-Pano-Carib Phylum. His Macro-Carib includes the isolates Andoke and Kukura, and the Witotoan, Peba-Yaguan, and Cariban families. Greenberg's primary evidence came from person-marking paradigms in individual languages, plus scattered words from individual languages collected into 79 Macro-Carib 'etymologies' and another 64 Amerind 'etymologies'. The goal of this paper is to re-evaluate Greenberg's Macro-Carib claim in the light of the much more extensive and reliable language data that has become available largely since 1987. Based on full person-marking paradigms for Proto-Cariban, Yagua, Bora and Andoke, we conclude that Greenberg's morphological claims are unfounded. For our lexical comparison, we created lexical lists for Proto-Cariban, Proto-Witotoan, Yagua and Andoke, for both Greenberg's 143 putative etymologies and for the Swadesh 100 list. From both lists, a total of 23 potential cognates were found, but no consonantal correspondences were repeated even once. We conclude that our greatly expanded and improved database does not provide sufficient evidence to convince the skeptic that the Macro-Carib hypothesis is viable
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Kahlon, Rubab Zafar, e Ibtisam Butt. "Assessment of Forest Resource Exploitation in the Rural Communities of District Jhelum, Pakistan". International Journal of Economic and Environmental Geology 10, n.º 3 (12 de novembro de 2019): 16–21. http://dx.doi.org/10.46660/ijeeg.vol10.iss3.2019.302.
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18 October, 2019 Accepted: 25 October, 2019Abstract: Forest resources are deteriorating and experiencing decline around the globe due to unsustainable use andover exploitation. The present study was an attempt to determine the relationship between human activities, forestresource utilization, extraction methods and practices of forest resource exploitation in the district Jhelum of Pakistan.For this purpose, primary sources of data were used which were collected from 8 villages through structuredquestionnaire and tabulated in Microsoft Excel 365 and SPSS 22 was used for multiple linear regression analysis. Theresults revealed that farming, wood cutting, animal husbandry and agro-forestry were the major occupations in thestudy area. Most commonly used resources included timber 26%, fuelwood 25% and fodder 19%. Methods used forresource extraction included gathering 49%, plucking 34% trapping 11% and cutting 6%. Population growth, increaseddemand of fuelwood and land conversion were the main reasons behind forest degradation. Results for multiple linearregression revealed that Forest based activities, sources of energy production, methods used for wood harvesting andresource extraction and use of fuelwood for energy production contributed significantly towards extensive forestresource exploitation with p value <0.5 within the study area. The study suggests that effective measures should betaken by forest department to control the unsustainable use of forest resources by stringent management interventionsand awareness campaigns in Jhelum district.
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Kahlon, Rubab Zafar, e Ibtisam Butt. "Assessment of Forest Resource Exploitation in the Rural Communities of District Jhelum, Pakistan". International Journal of Economic and Environmental Geology 10, n.º 3 (12 de novembro de 2019): 16–21. http://dx.doi.org/10.46660/ojs.v10i3.302.
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18 October, 2019 Accepted: 25 October, 2019Abstract: Forest resources are deteriorating and experiencing decline around the globe due to unsustainable use andover exploitation. The present study was an attempt to determine the relationship between human activities, forestresource utilization, extraction methods and practices of forest resource exploitation in the district Jhelum of Pakistan.For this purpose, primary sources of data were used which were collected from 8 villages through structuredquestionnaire and tabulated in Microsoft Excel 365 and SPSS 22 was used for multiple linear regression analysis. Theresults revealed that farming, wood cutting, animal husbandry and agro-forestry were the major occupations in thestudy area. Most commonly used resources included timber 26%, fuelwood 25% and fodder 19%. Methods used forresource extraction included gathering 49%, plucking 34% trapping 11% and cutting 6%. Population growth, increaseddemand of fuelwood and land conversion were the main reasons behind forest degradation. Results for multiple linearregression revealed that Forest based activities, sources of energy production, methods used for wood harvesting andresource extraction and use of fuelwood for energy production contributed significantly towards extensive forestresource exploitation with p value <0.5 within the study area. The study suggests that effective measures should betaken by forest department to control the unsustainable use of forest resources by stringent management interventionsand awareness campaigns in Jhelum district.
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Zeidan, Muna. "Factors Associated with Anemia in A sample of Pregnant Women Attending Primary Health Centers". Iraqi National Journal of Nursing Specialties 26, n.º 3 (30 de dezembro de 2013): 20–29. http://dx.doi.org/10.58897/injns.v26i3.184.
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Objective (s): To determine proportion of anemia among sample of Pregnant women. To identify factorsassociated with the anemia (Maternal age, maternal education, gestational age, parity, gravidity, birthinterval, smoking, taking iron supplements and dietary habits).Methodology: A cross-sectional study conducted at Al- washash & Bab-almoadham primary health carecenters. The sample was selected by (non-probability convenient sampling) and sample size was (550).The study started from 1st March 2011 to 30th of March 2012. The data was collected by direct interviewusing special questionnaire to obtained socio-demographic information.Results: the result shows that mean age of the subjects was 26.5± 7.5 years, 85.8% were housewives;about (45.6%) of pregnant women in the sample were anemic. About (52.2%) of the pregnant womenwith anemia were mainly at 3rd trimester of their pregnancy. Analysis of results by chi-square test showthat (Maternal age, maternal education, gestational age, parity, gravidity, birth interval, smoking, takingiron supplements and dietary habits) were significant factors associated with anemia.Recommendations: the present study recommends that priority should be given to provide education andother social services in on the prevention of pregnancy-induced anemia.
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Mansoor, Nurulhana Shaikh, Farnaza Ariffin, Leny Suzana Suddin e Zati Sabrina Ahmad Zubaidi. "Knowledge, Attitude and Factors associated with Self-efficacy in Screening and Treatment of Hepatitis C among Primary Care Doctors in Selangor". Malaysian Family Physician 19 (20 de fevereiro de 2024): 11. http://dx.doi.org/10.51866/oa.454.
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Introduction: Primary care doctors (PCDs) play an increasingly important role in the management of hepatitis C. It is essential for PCDs to have good self-efficacy in screening and treating hepatitis C to achieve good outcomes. This study aimed to determine the knowledge and attitude towards andother factors associated with self-efficacy in screening and treating hepatitis C. Methods: This cross-sectional study was conducted using an online Google Form. PCDs workingat primary healthcare clinics were selected via simple random sampling. The online form contained items on sociodemographic and practice characteristics and a validated questionnaire on knowledge,attitude and self-efficacy towards screening and treating hepatitis C. Data were statistically analysed. Results: A total of 242 PCDs were included in the analysis. The median age was 35 years(interquartile range [IQR]=5). The majority of the PCDs were women (83.9%) and Malay (71.9%)and had a median working experience of 6 years (IQR=6). The mean self-efficacy score was 12.67(standard deviation=3.38). The factors associated with a higher level of self-efficacy in screening and treating hepatitis C were postgraduate qualification, training within the last one year, better knowledge and attitude scores and prior experience in treating hepatitis C. Conclusion: The identified factors are crucial in improving the self-efficacy among PCDs in hepatitis C care services. Policymakers are suggested to implement training programmes and encourage continuous medical education, exposure to patient management and postgraduate certification in family medicine to help PCDs in treating hepatitis C better.
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Toci, Valentin, e Iraj Hashi. "Law Enforcement Proxies Matter for the Law and Finance Nexus". International Journal of Finance & Banking Studies (2147-4486) 2, n.º 3 (21 de julho de 2013): 57–75. http://dx.doi.org/10.20525/ijfbs.v2i3.154.
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The paper employs various measures of law enforcement to provide new evidence on the importance of legal institutions for different dimensions of financial development in transition economies. It offers a critical assessment of law enforcement measures employed in recent studies by showing that some proxies for law enforcement in the credit market may not be appropriate. Hence, care should be taken in how the quality of institutions is measured and the context which it represents. An original approach to measuring law enforcement in the credit market is developed by embodying the legal theory of dispute resolution and assessing this approach by collecting primary data for Kosovo. The findings suggest that Kosovo compares well with countries in the region andother transition economies in terms of the enforcement of creditor rights.
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Atichartakarn, Vichai, Suporn Chuncharunee, Sukit Yamwong, Teerapat Yingchoncharoen, Sutipong Jongjirasiri, Napaporn Archararit, Umaporn Udomsubpayakul e Katcharin Aryurachai. "Relationship Between Pulmonary Artery Pressure and Spleen Volume in Non-Splenectomized Hemoglobin E/β-Thalassemia Patients". Blood 118, n.º 21 (18 de novembro de 2011): 2156. http://dx.doi.org/10.1182/blood.v118.21.2156.2156.
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Abstract Abstract 2156 Introduction: Clinically significant pulmonary arterial hypertension (PAH) has been reported in splenectomized hemoglobin E/β-Thalassemia patients. Like primary PAH, the underlying basis is hypercoagulability related thrombotic pulmonary arteriopathy, which results in an increased pulmonary vascular resistance. In the non-splenectomized counterparts with no clear evidence of hypercoagulability only mild PAH is found. To evaluate role of splenomegaly and the accompanying increased blood volume in the pathogenesis of PAH in this group of patients, we studied the relationship between spleen volume and PA pressure. Patients and Methods: Nineteen clinically stable hemoglobin E/β-Thalassemia outpatients, on no medication aside from folic acid and who received no blood transfusion in the preceding 4 weeks were first analyzed in this ongoing study. All gave written informed consent, and study protocol was approved by the institution ethics committee on studies in humans (ID 07–53-01). PA pressure (PAP) was estimated by a single echocardiologist (T.Y.) using Philips iE33 echocardiographic system with a S5 probe (Philips Medical Systems, Andover, MA). Spleen volume was determined by CT scan with non-contrast, 320-slice, 3 mm axial cut (Aquilion one, Toshiba, Japan). Statistical analysis of clinical and laboratory data was done by SPSS version 18 (SPSS Inc, Chicago, Ill), considering a P value <0.05 as statistically significant. Results: Patients' characteristics are shown. Results are expressed as mean ± SD or median (range) where appropriate. All had normal left ventricular systolic ejection fraction and no valvular heart disease. There was good correlation (r=0.609, P=0.006) between spleen volume and mean PAP. Conclusions: Non-splenectomized patients with hemoglobin E/β-Thalassemia have elevated PAP in proportion to spleen size, likely secondary to elevated blood volume. This situation is distinct from the pathologic PAH that results from increased pulmonary vascular resistance in splenectomized patients. Disclosures: No relevant conflicts of interest to declare.
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Bernardoni, Eamon, Rachel M. Frank, Shreya S. Veera, Justin W. Griffin, Brian Robert Waterman, Elizabeth Shewman, Brian J. Cole, Anthony A. Romeo e Nikhil N. Verma. "Biomechanical Analysis of All-Suture Anchor Fixation for Rotator Cuff Repair". Orthopaedic Journal of Sports Medicine 6, n.º 7_suppl4 (1 de julho de 2018): 2325967118S0017. http://dx.doi.org/10.1177/2325967118s00175.
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Objectives: Suture anchors are commonly utilized during arthroscopic rotator cuff repair (RCR). Recently, all-suture suture-anchor (ASSA) constructs have been introduced for RCR; however, the biomechanical properties of these implants are poorly understood. The purpose of this study was to compare the biomechanical properties of ASSA to conventional suture anchor (CSA) fixation during RCR. Methods: Fourteen fresh-frozen matched pair human cadaveric shoulders (average age 52 ± 13 years) with no documented prior rotator cuff tears or shoulder surgery were dissected. The supraspinatous tendon was isolated and detached from its footprint, and then was repaired in an anatomical position. Specimens were randomized into two repair constructs: Q-FIX double-loaded ASSA (N=7) and TWINFIX double-loaded conventional suture anchor (CSA) (N=7) (Smith & Nephew, Andover, MA). Each construct was cyclically loaded from 10 to 160 N for 100 cycles at 100N/s, and then pulled to failure at 1mm/s starting from the zero position. Load, crosshead displacement, failure mode, and time were recorded. Correlations between BMD, tendon gage length, maximum load, and stiffness were assessed. The groups were statistically analyzed with independent samples t-test, Fisher’s exact test, and a linear regression analysis, with p<0.05 considered significant. Results: There was no statistically significant difference in maximum load (ASSA: 617.73±177.8, CSA: 545.13±212.98 N, p=0.339), cyclic extension (ASSA: 7.88±1.33, CSA: 8.49±2.14 mm, p=0.117), construct stiffness (ASSA: 62.43±11.06, CSA: 68.14±10.77 N/mm, p=0.973), or extension at maximum load (ASSA: 17.03±4.73, CSA: 15.45±1.73 mm, p=0.122) between the ASSA and CSA groups. Failure modes consisted of suture tearing out of the tendon (ASSA: N=3, CSA: N=3) and anchor pull out (ASSA: N=4, CSA: N=4), with no difference in failure mode between groups (p=0.99). An association trended towards significance between higher BMD and higher maximum load in the CSA group (p=0.053) but not the ASSA group (p=0.125) Conclusion: ASSA constructs for RCR have similar biomechanical properties compared to CSA constructs. Additional clinical data is necessary to determine if these biomechanical results can be translated clinically.
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Kalawar, Rosan Prasad Shah, Pashupati Chaudhary, Raju Rijal e Bishnu Pokharel. "The Associated Meniscal Tears and Associated Risk Factors in Concomitant ACL Injuries of the Knee: A Retrospective Analysis". Birat Journal of Health Sciences 5, n.º 1 (26 de junho de 2020): 981–85. http://dx.doi.org/10.3126/bjhs.v5i1.29639.
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Introduction: The pattern of meniscus tear has significant impact onsubsequent rehabilitation and functional outcome as theyare usually associated with ACL injury.Knowledge about associated meniscus tear helps to identifypatients in the early post-traumatic phase.
Objectives: To study meniscus tear patterns and associationbetween different tear patterns of meniscus in ACLinjured subjects and to identify potential demographic andother associated risk factors.
Methodology: Routine arthroscopic findings database of 54 patientsoperated for primary ACL reconstruction from January 2017to December 2018 was used to study associated tear of meniscus. Based on arthroscopic evaluation, cases weregrouped into meniscus having no tear, minor tear and majortear. Major tear included complete radial tears, root tearsand unstable longitudinal tears including bucket-handletears.
Result: Totalarthroscopycasesinthestudydurationwere124.Ofthose,43% (n=54) underwent ACL reconstruction (ACLR) for tornACL. Among the patients who underwent ACLR, 58% had notear, 26%hadminortears, and16%hadmajortears ofthemeniscus. Therewere significant differencesbetweenthree groups for gender, age groupsandmechanism of injury. Risk factors formajortearsweremalegenderandage<30years.Minorandmajortears were associated with a contact injury.
Conclusion: Male, age <30 years and history of contact injury havehigh risks for having an associated meniscus tear. Earlyreferral to magnetic resonance imaging and/or arthroscopyis recommended to allow meniscus repair in a timelymanner.
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Adie, John, Wayne Graham e Marianne Wallis. "Entry Points to the Health System: a review of the emerging community models for management of non-life threatening urgent conditions relevant to Australia". Asia Pacific Journal of Health Management 12, n.º 2 (18 de julho de 2017): 9–16. http://dx.doi.org/10.24083/apjhm.v12i2.71.
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Problem: The number of presentations to Emergency Departments (EDs) is increasing at levels above population growth rates and these increases are becoming unsustainable.
Objective: To review evidence for emerging entry points to the health system for patients with non-life threatening urgent conditions (NLTUC) in order to consider more effective healthcare services in Australia.
Methods: An in-depth review of the Emerald, Medline, CINAHL, Web of Science, Proquest Business and Medical databases from January 2005 to April 2016 matching ‘acute care’ or ‘urgent care’ with general practice andother health providers found thirteen entry point models with five currently relevant to Australia.
Results: Studies examining five emerging entry points were found including urgent care community pharmacy, new prehospital practitioner community care, advanced nurse enhancement of primary care, designated urgent care clinics and integrated primary care centers. Evidence for these emerging models of community healthcare is presented including emerging initiatives, cost implications, subsequent admission to hospital, satisfaction, mortality, care, treatment time, subsequent referrals, testing and health outcomes.
Conclusion: These emerging models of community healthcare need to be trialed and studied in the Australian context to evaluate whether they provide patients with NLTUC with a safe cost-effective option with similar outcomes to EDs. Implementation of these models can be examined further to determine their effectiveness in potentially reducing the increasing rate of presentation to EDs.
Abbreviations: APCN – Advanced Primary Care Nurse; ECP – Emergency Care Practitioners; ED – Emergency Department; GP – General Practitioner; IPCC – Integrated Primary Care Centre; PP – Paramedic Practitioners; NLTUC – Non-Life Threatening Urgent Conditions; UCC – Urgent Care Clinics; UCCP – Urgent Care Community Pharmacy.
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Azzahra, Elsya Ikhsani. "Tindak Pidana Kekerasan Seksual Inses pada Anak dalam Hukum Positif Indonesia". Journal of Contemporary Law Studies 2, n.º 1 (1 de fevereiro de 2024): 64–74. http://dx.doi.org/10.47134/lawstudies.v2i1.2128.
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The present study explores the phenomenon of incest, defined as a forbidden marital orrelational alliance wherein individuals engage in matrimonial or sexual relations due toconsanguinity or close familial ties. Incest is categorized within the realm of familial abuseor domestic violence, encapsulating acts wherein individuals coerce or compel their kin intoengaging in sexual activities. The primary objective of this research is to furnish readerswith a comprehensive comprehension of incestuous sexual violence against minors,elucidating the causative factors, typologies, repercussions on child victims, and thetherapeutic interventions available for both victims and perpetrators. Employing a legalresearch paradigm with a normative juridical research approach, this investigationprimarily relies on library studies or document analyses centered on written statutes andother legal materials. The factors contributing to incestuous incidents are discernedthrough an internal-external dichotomy, whereby internal factors pertain to thepsychological instability of the offender, and external factors relate to residing in a familialmilieu characterized by low socio-economic conditions. Children subjected to incestuoussexual violence often manifest profound behavioral alterations. Consequent adverse effectsmay include early pregnancies, with associated risks of abortion, and progeny resultingfrom incestuous unions are predisposed to heightened probabilities of physical and mentaldisabilities. Consequently, it is imperative to foster collaboration among social institutions,the community, the state, and familial units to proactively prevent and address incidentsof incestuous sexual violence.
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Rizvi, Sajjad H. "Islam and the Army in Colonial India". American Journal of Islam and Society 27, n.º 3 (1 de julho de 2010): 122–25. http://dx.doi.org/10.35632/ajis.v27i3.1317.
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After what seems like a strange absence of academic interest, the study ofMuslims in South Asia is catching up – and not all of that interest is motivatedby the contemporary concerns of counter-terrorism and Af-Pak strategy.Part of this intellectual revival has been focused on the Deccan, andone of the best and brightest young historians working in the area is NileGreen, who now teaches at UCLA.The author posits three primary contributions to wider historiographicaldebates. First, it engages the social history of how empire impingedupon communities and practices and often co-opted and promoted them,thereby allowing us greater insight into its workings to suggest that partnershipswere essential to perpetuating power, especially in India, wherethe number of actual British soldiers and administrators on the ground wasnever sufficient for an absolutist colonial empire. As such, it allows us topeek into an alternative form of subaltern interaction and agency. This issignificant, given the neglect to a large extent of the study of religion onthe part of subalternists. Second, the book demonstrates how cultural practicesand the invention of norms were central to fostering military cultureand performance of the British Indian Army, which involves the selectivepromotion of certain forms of religiosity. It provides further evidence for ...
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Koerner, Michael M., Ali Ghodsizad, Uwe Schulz, Aly El Banayosy, Reiner Koerfer e Gero Tenderich. "Normothermic Ex Vivo Allograft Blood Perfusion in Clinical Heart Transplantation". Heart Surgery Forum 17, n.º 3 (3 de julho de 2014): 141. http://dx.doi.org/10.1532/hsf98.2014332.
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<p><b>Background:</b> Cold ischemia associated with cold static storage is an independent risk factor for primary allograft failure and survival of patients after orthotopic heart transplantation. The effects of normothermic ex vivo allograft blood perfusion on outcomes after orthotopic heart transplantation compared to cold static storage have been studied.</p><p><b>Methods:</b> In this prospective, nonrandomized, single-institutional clinical study, normothermic ex vivo allograft blood perfusion has been performed using an organ care system (OCS) (TransMedics, Andover, MA, USA). Included were consecutive adult transplantation patients who received an orthotopic heart transplantation (oHTx) without a history of any organ transplantation, in the absence of a congenital heart disorder as an underlying disease and not being in need of a combined heart-lung transplantation. Furthermore, patients with fixed pulmonary hypertension, ventilator dependency, chronic renal failure, or panel reactive antibodies >20% and positive T-cell cross-matching were excluded. Inclusion criteria for donor hearts was age of <55 years, systolic blood pressure >85 mmHg at the time of final heart assessment under moderate inotropic support, heart rate of <120 bpm at the time of explantation, and left ventricular ejection fraction >40% assessed by an transcutaneous echo/Doppler study with the absence of gross wall motion abnormalities, absence of left ventricular hypertrophy, and absence of valve abnormalities. Donor hearts which were conventionally cold stored with histidine-tryptophan-ketoglutarate solution (Custodiol; Koehler Chemie, Ansbach, Germany) constituted the control group. The primary end point was the recipients' survival at 30 days and 1 and 2 years after their heart transplantation. Secondary end points were primary and chronic allograft failure, noncardiac complications, and length of hospital stay.</p><p><b>Results:</b> Over a 2-year period (January 2006 to July 2008), 159 adult cardiac allografts were transplanted. Twenty-nine were assigned for normothermic ex vivo allograft blood perfusion and 130 for cold static storage with HTK solution. Cumulative survival rates at 30 days and 1 and 2 years were 96%, 89%, and 89%, respectively, whereas in the cold static storage group survival after oHTx was 95%, 81%, and 79%. Primary graft failure was less frequent in the recipients of an oHTx who received a donor heart which had been preserved with normothermic ex vivo allograft blood perfusion using an OCS (6.89% versus 15.3%; <i>P</i> = .20). Episodes of severe acute rejection (23% versus 17.2%; <i>P</i> = .73), as well as, cases of acute renal failure requiring haemodialysis (25.3% versus 10%; <i>P</i> = .05) were more frequent diagnosed among recipients of a donor heart which had been preserved using the cold static storage. The length of hospital stay did not differ (26 days versus 28 days; <i>P</i> = .80) in both groups.</p><p><b>Conclusions:</b> Normothermic ex vivo allograft blood perfusion in adult clinical orthotopic heart transplantation contributes to better outcomes after transplantation in regard to recipient survival, incidence of primary graft dysfunction, and incidence of acute rejection.</p>
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Swart, Christelle, e Sonja Verwey. "use of technology in relationship management". Communicare: Journal for Communication Studies in Africa 22, n.º 1 (24 de outubro de 2022): 80–99. http://dx.doi.org/10.36615/jcsa.v22i1.1797.
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Technological innovations have changed many aspects of public relations practice, andpublic relations is believed to have entered the “fourth wave” of technological changein the field. To achieve its ultimate objective, namely to build and maintain beneficialrelationships, thus contributing to achieving organisational goals, it is pivotal to explorethe impact of technology on the profession and practice of public relations. Knowledgeof the impact of these innovations will equip public relations with the required knowhow to contribute to the overall objectives of an integrated communication approach.While technology in itself cannot build or destroy relationships as maintained by Kent& Taylor (1998:324), the way in which technology is used can influence organisationpublic relationships, hence emphasising the need for public relations professionals tocome to terms with new technology and the opportunities and challenges it holds.An exploratory study was undertaken to provide new insights into the impact of newcommunication technology on the profession and practice of public relations in SouthAfrica. The primary purpose of the study was to determine the availability and use ofnew communication technology by South African public relations professionals forinternal and external relationship management. It comprised a theoretical and conceptualanalysis of public relations practice and models, dominant business approaches andother concepts related to the objectives of this study. The literature study wassupplemented by a pilot study concerning the availability and use of technology byPRISA-accredited public relations practitioners. This article reports on the findings ofthe empirical section of the study
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Kaluntas, Tita Natalia, Olly Esry Harryani Laoh e Yolanda Pinky Ivanna Rori. "EVALUASI PENGELOLAAN DANA DESA DI DESA KALASEY DUA KECAMATAN MANDOLANG KABUPATEN MINAHASA". AGRI-SOSIOEKONOMI 15, n.º 1 (4 de julho de 2019): 55. http://dx.doi.org/10.35791/agrsosek.15.1.2019.23364.
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This study aims to evaluate Village Fund management in Kalasey Dua illage, Mandolang Sub-district, Minahasa Regency. The study was conducted from May 2018 to January 2019. The data used in this study were primary data and secondary data. Primary data was collected based on interviews with two members of the Village Consultation Board (BPD), three village officials, and 50 community members to find out their responses to Village Fund management. The fifty community members were selected community members that have over the age of 21 years and had lived in the research village for more than 10 years. So the total respondents were 55 people.Interviews with community members were used by Likert Scale. Secondary data in this study came from the archives and reports of Kalasey Dua Village office in the form of Village Monographs, Village Fund Management Data andother documents relating to the management of the Kalasey Dua Village Village Fund; and through books available at local bookstores; and the internet. Internet used google searching to access articles from various scientific journals and theses from other universities related to the topic of this research. Data analysis using descriptive analysis. The results of the study indicate that overall the Village Funds received in Kalasey Dua Village have been managed properly by the government or the management, both in the management procedure with the availability of documents; and adhere to the principles of village fund management that consists of justice, needs, village authority, participation, self-management and village-based resources, village typology, transparency and accountability; and the community have felt the benefits. The Village Fund has been giving benefit to community of the village, both in the construction of infrastructure (roads, culverts, solar street lighting) and the empowerment of rural communities (by technical guidance of the management of Village-Owned Enterprises or BUMDES outside the region).*gmhk+erprm*
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Serikova, O. M., V. V. Syvochka e D. V. Fomenko. "Problems of forming competitive regional innovation systems". Вісник Східноукраїнського національного університету імені Володимира Даля, n.º 1 (281) (14 de fevereiro de 2024): 49–54. http://dx.doi.org/10.33216/1998-7927-2024-281-1-49-54.
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The creation of conditions for the development ofintegrated research, education and business complexeswill be possible through the interaction of political,regulatory, economic, social and cultural factors.Political conditions are determined at the state level. Atthe same time, the integration of education, science andinnovative business has faced some problems, inparticular, related to governance. Therefore, the maintask at present is to ensure real integration in thesesectors in order to ensure innovative transformations notonly in the economy but also in society as a whole, andthe ministry should restructure the management of theseareas to adequately meet this task. For example, theproject to modernize universities envisages that theyshould become a place where people are trained toperceive innovative ideas, to be formed into specialists ina new way, and to be the driving force behind innovativedevelopment. It has also become clear that it is necessaryto move from training specialists in mass professions totraining specialists capable of ensuring the operation ofmodernized enterprises and enterprises that useinnovative technologies aimed at producing innovativeproducts. The vocational education system has alreadybegun to restructure in this direction, with resourcecenters emerging that bring together primary, secondary,and higher vocational education institutions to build achain of training for all levels of personnel focused onadvanced manufacturing. At the present stage, theproblems of integrated formation and development ofscience and education are being solved, but themechanism of systemic influence through the creation ofintegrated regional research and education complexes -research (leading) universities of a new type - is not used.The experience of implementing integration processes ofacademic and university science and production showsthat the development of a specific model and itsorganizational and legal formalization require resolvingthe issues of identifying the lead organization and coexecutors,which will determine the type of integrationmodel, scientific, educational, social, environmental andother problems to be solved. In this case, it is importantto choose the organizational and legal form ofinteraction between the structures formed as part of thenew entity, the distribution of responsibilities of allparticipants in addressing issues of staffing, inventoryand equipment, financing for each participant through aninterconnected system of legal documents andregulations, reporting, etc.
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Abbas Shah, Tajammal. "COLONIC CANCER". Professional Medical Journal 23, n.º 03 (10 de março de 2016): 251–56. http://dx.doi.org/10.29309/tpmj/2016.23.03.1467.
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A prospective study was conducted to see presentation and management of coloniccancer presenting to a surgical unit in a teaching hospital at Faisalabad. Objectives: To knowdifferent presenting symptomatology like abdominal mass, pain, intestinal obstruction, alteredbowel habits, rectal bleeding, age co-relation, sex distribution, anatomic location among coloniccancer patients and management done for these patients. Study Design: A prospective study.Period: February 2009 to March 2010 for one year. Material and Methods: Total 8 patients werediagnosed and treated for colonic cancer presenting in a single surgical ward. Patients with ageabove 14 years were included in study while patients presenting with trauma and metastaticdisease for other carcinoma were excluded. Results: Among 8 patients diagnosed for coloniccancer, age’s range from 26 to 50 years at maximum, 2 patients (25 %) were males and 6 patients(75 %) were females. Only one patient (12.5%) presented with single complaint of left iliac fossamass, 2 patients (25 %) with only single complaint of rectal bleeding as a presenting symptomwhile all other 5 patients (62.5%) presented with more than one or two symptoms at the sametime. Among 5 patients presented with more than one symptom all had presented with abdominalmass associated with additional symptoms like, one patient (12.5%) developed intestinalobstruction with left sided abdominal mass, another one patient (12.5%) left sided abdominalmass with alternate diarrhea and constipation, another one patient (12.5%) right sided masswith pallor, one patient (12.5%) had constipation with left sided mass while another one patient(12.5%) developed abdominal pain, weight loss and palpable left sided abdominal mass. Patientswere staged according to TNM staging system. All patients were above stage II and Dukes B. Allpatients were operated in Surgical Unit II at Allied Hospital Faisalabad. Left hemi-colectomy wasdone for 2 patients; right hemi-colectomy was done for single patient presented with mass andanemia on right side, sigmoid resection with colostomy for one patient, Hartmann’s procedurefor another one patient and single stage resection with primary anastomosis for one patient. 2patients underwent abdomino-perineal resection with end colostomy. Conclusion: This studytells that majority of the patients with colon cancer presented with left sided abdominal mass andother associated symptom, the age’s range from 26 to 50 years. Disease affected 6 females out oftotal 8 patients. Two patients underwent APR with end colostomy while other patients were treatedwith alternate procedures like primary anterior resection with anastomosis or end colostomy
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Veith, Thomas A., Richard Beck e Noemi Andor. "Abstract A027: Detecting and modeling frequency-dependent evolution in serially passaged primary triple negative breast cancer patient derived xenografts". Cancer Research 84, n.º 3_Supplement_2 (1 de fevereiro de 2024): A027. http://dx.doi.org/10.1158/1538-7445.canevol23-a027.
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Abstract Tumor evolution is a contributing factor to most failed cancer treatments. The intratumor heterogeneity of cellular phenotypes found in the tumor microenvironment acts as an evolutionary substate for cancer cells during tumorigenesis, subsequent growth, and after the patient is in the clinic. Selective forces imposed by certain medications can cause the emergence of a tumor with a resistant phenotype. Chemotherapies that target rapidly dividing cells will select for slower dividing ones which are less sensitive to such agents. However, many selective pressures acting on the tumor microenvironment are yet to be elucidated. For example, the effect one cancer cell has on another’s growth through competitive (i.e., the struggle for resources) or cooperative (e.g., exchange of growth factors) interactions remains poorly understood. Our central hypothesis is that cancer cells with distinct karyotypes will have a varying growth rate influenced by the karyotype landscape of the entire tumor. That is, we expect the fitness of a cancer cell to be largely determined by its karyotype and the karyotypes of its neighbors. Thus, we predict that frequency-dependent selection has a significant impact on clonal evolution in cancer. To test this, we have developed two novel methods for respectively identifying likely instances of frequency-dependent selection and modeling the long-term evolutionary trajectory in such cases. To detect frequency-dependent effects, we investigate the relationship between the frequency of one clone and the growth rate of all others (including itself). If a statistically significant correlation can be found, we proceed to modeling clonal evolution. To do this, we use a penalized least squares method and find the best-fitting parameterization of the replicator equation to the clonally resolved frequency data. This provides us with a payoff matrix describing the intensity of competition between each pair of clones. Furthermore, it allows us to model the long-term evolutionary dynamics of the tumor and to make predictions regarding co-existence of clones or clonal sweeps. Recently, investigators serially passaged primary triple negative breast cancer (TNBC) patient derived xenograft (PDX) tumors in NRG mice for over a year, inferring clonal frequencies at multiple timepoints using single cell whole genome (scWGS) and RNA sequencing (scRNA-seq). From this data, we were able to detect statistically significant frequency-dependent effects in the majority of serially passaged PDX tumors. Of these, most are predicted to result in a clonal sweep. Three of the PDX tumors were treated with cisplatin which revealed clone-specific drug response. This presents an opportunity for adaptive therapy scheduling which takes advantage of fitness tradeoffs under different contexts. A greater understanding of the effects frequency-dependent selection has on tumor evolution will contribute to the design of therapies intended to preclude or delay the emergence of resistance to treatment. Citation Format: Thomas A. Veith, Richard Beck, Noemi Andor. Detecting and modeling frequency-dependent evolution in serially passaged primary triple negative breast cancer patient derived xenografts [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: Translating Cancer Evolution and Data Science: The Next Frontier; 2023 Dec 3-6; Boston, Massachusetts. Philadelphia (PA): AACR; Cancer Res 2024;84(3 Suppl_2):Abstract nr A027.
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Badewy, Rana, Michael Glogauer, Amir Azarpazhooh, Howard Tenenbaum, Kristin Connor, Michael Sgro, Richard Bazinet et al. "67 Infant Health Status Impacts the Neutrophil Phenotypes and Polyunsaturated Fatty Acids Composition in Human Milk". Paediatrics & Child Health 28, Supplement_1 (1 de setembro de 2023): e30-e31. http://dx.doi.org/10.1093/pch/pxad055.067.
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Abstract Background The abundance of human milk leukocytes, including neutrophils, changes in response to the health status of mothers and their infants. Elevated leukocyte counts occur during infant infection and return to baseline levels upon recovery. However, it is unclear how infant health status can affect the neutrophil phenotypes and the concentration of fatty acids in their mothers’ human milk. Objectives This study investigates the association between infant health status and human milk neutrophil counts and activation state, and fatty acid levels, in human milk. Design/Methods This is a prospective cohort study of 50 healthy breastfeeding mothers recruited from St. Michael’s hospital, in Toronto, Ontario, who were followed up from 2-4 weeks until 4 months postpartum. Human milk samples were collected from participants and data regarding infant health status were collected from self-reported questionnaires completed by participants at both timepoints, then imputed based on whether infants had taken antibiotics, had been hospitalized, or had been diagnosed with a medical condition, at least 2 weeks prior to samples collection. Neutrophils were quantified using flow cytometry and labelled with a panel of antibodies to detect specific cluster of differentiation (CD) biomarkers. Fatty acids were identified and quantified using a gas chromatography-flame ionization detector (GC-FID). Linear mixed-effects models were used to evaluate the correlation between infant health status and changes in neutrophil counts, along with their expressed CD markers, and fatty acids composition in human milk during lactation. Results The CD markers were classified into 4 categories based on their function: degranulation/activation markers (CD63, CD64, and CD66a), an immunoregulation marker (CD16), adhesion markers (CD11b, CD18), and a lipopolysaccharide receptor (CD14). Human milk from mothers whose infants had a health condition had neutrophils which significantly expressed elevated levels of the CD64 biomarker (β: 85.65, p=0.009 in adjusted models), compared to human milk from mothers of healthy infants. However, there were no significant associations between infant health status, absolute hmPMN counts, andother CD biomarkers (p>0.05). There were also elevated levels of arachidonic acid (β: 0.12, p=0.013) and C22:5n-6 (β: 0.06, p=0.015) fatty acids in the human milk of mothers whose infants had a health condition, compared with human milk from mothers of healthy infants, after adjusting for maternal age, post-pregnancy body mass index, infant sex, and infant feeding pattern. Conclusion This study demonstrates that infant health status is associated with changes in human milk immunological components, suggesting an inflammatory protective response mechanism in the mammary glands triggered by infants infection. How these alterations can affect infant health outcomes in the short and longer terms need critical consideration.
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ÖZSOY, Metin, e Necla TÜLEK. "The impact of COVID-19 pandemic on surveillance of influenza and influenza-like viruses: a single center experience". Journal of Health Sciences and Medicine 6, n.º 4 (30 de julho de 2023): 756–62. http://dx.doi.org/10.32322/jhsm.1303422.
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Aims: Influenza and the agents responsible for influenza-like illness (ILI) are a significant cause of upper and lower respiratory tract infections, with a notable pattern of seasonal incidence. The surveillance of influenza and agents causing ILI is important for the developmentof a prophylaxis approach and infection control. In the present study, we utilize the Reverse transcription-polymerase chain reaction (RT-PCR) method to identify the presence of influenza virus and other agents associated with ILI in nasopharyngeal smears obtained from patients exhibiting symptoms of influenza and ILI. The study sample included patients who were admitted to multiple clinics and intensive care units (ICU) of the Health Sciences University Ankara Training and Research Hospital in the period preceding, and in the initial months and first year following the coronavirus disease 2019 (COVID-19) outbreak. Throughthe comparisons made in the study, the intention is to gain a better understanding of the influence of the COVID-19 pandemic on other viral infectious agents transmitted via the respiratory tract.
Methods: Included in the study were 257 admitted to different wards and ICUs of our hospital due to symptoms of upper or lower respiratory tract infection and ILI between 2015 and 2021 (excluding data from 2017–2018). The study was conducted prospectively within the scope of the Global Influenza Hospital Surveillance Network project. Using sterile swabs, nasopharyngeal swab samples were collected from inpatients who provided informed consent for their participation in the study, and the samples were placed in a viral transport medium. The presence of influenza viruses (Influenza A, subtypes of Influenza A and Influenza B) and agents causing ILI (i.e. respiratory syncytial virus, coronavirus) was investigated with an RT-PCR approach.
Results: The most common symptoms among the 257 patients included in the study with pre-diagnoses of influenza and ILI were cough (82.2%), fever (67.7%), shortness of breath (66.1%) and myalgia (40%). The RT-PCR detected a viral agent in 60 (23.3%) of the 257 patients, whereas no agent could be detected in 197 (76.6%) patients. Furthermore, 51 (18.5%) tested positive for influenza virus, five (1.9%) for respiratory syncytial virus (RSV), and four (1.5%) for SARS-CoV-2. An analysis of the results within two distinct time frames, namely prior to the COVID-19 pandemic (2016–2017, 2019–prior to December 10, 2020) and during the COVID-19 pandemic (between December 11, 2020 and 2021), influenza viruses (influenza A H1N1 and influenza A H3N2), RSV and influenza type B were identified as the dominant viruses before the COVID-19 pandemic, while the predominant viruses were a single influenza strain and four SARS-CoV-2 variants during the COVID-19 pandemic.A significant difference was noted in the distribution of viruses between the two time frames – prior to the pandemic and during the pandemic. Of the patients, 199 (77.4%) were discharged with full recovery while 58 patients died (22.6%). Of the 58 patients that died, 25 were female (25/131 females) and 33 were male (33/126 males), 11 had tested positive for influenza virus andone for RSV, while no infectious agent could be identified in 46 patients.
Conclusion: The implementation of molecular testing methods for the identification of viral infectious agents among inpatients during influenza and ILI outbreaks, administering antiviral and prophylactic treatments targeting influenza, RSV and SARS-CoV-2 infections, and adopting infection control measures, could significantly decrease mortality and morbidity rates while mitigating the complications associated with these infectious agents.
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Andor, Noemi. "Abstract 139: Exploiting interactions between ploidy and host physiology". Cancer Research 83, n.º 7_Supplement (4 de abril de 2023): 139. http://dx.doi.org/10.1158/1538-7445.am2023-139.
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Abstract Whole-genome doubling facilitates rapid tumor evolution and is a hallmark of many cancers, including Glioblastoma (GBM) where it has an incidence of ~14%. GBM remains uniformly lethal, with a median overall survival of 14-16 months, despite aggressive therapy. In people aged 65 and above, prognosis is even more dismal, with median survival of less than 7 months. While comorbidities explain some of the increased age-related risk, age-related changes in the tumor microenvironment likely also contribute. Aging brains have higher incidence of polyploidy (Pearson r=0.80; P=0.031; Nandakumar et al., 2021), hypoxia related gene expression (Pearson r =0.22, P =0.008) and Glucose levels (Ding et al., 2021) as well as decreased stiffness (Hiscox et al., 2018). The average ploidy of 20 different cancer types correlates with the Oxygen levels recorded in their respective tissue of origin (Spearman r = 0.66, P = 0.002). Together these results suggest that availability of metabolic substrates in the GBM environment drives different cell fate decisions in cancer cells of different ploidy and shapes GBM disease initiation. We address this hypothesis with integrated in-vitro and in-silico experiments and multi-omic and imaging analysis of primary and recurrent GBM. We genetically engineered cell lines to obtain diploid and tetraploid lineages for each and tested how exposure to variable gradients of glucose, hypoxia and phosphate affect their migratory patterns. We performed RNA-seq and WGS of multiple regions obtained from two patient-matched primary and recurrent GBM. Pre- and post-surgery MRI data was available from both surgeries and registered to a T1 map Atlas to quantify stiffness and oxygenation in the brain. This data was used to calibrate a Stochastic State-Space Model (S3MB) we developed to recapitulate re-growth of enhancing primary tumor margins into the respective recurrent tumor. The model domain is initiated from MRI data and consists of 4mm3 voxels. Each voxel state is defined by 8+ variables that are updated over time: Stiffness, Oxygen, Phosphate, Glucose, Vasculature, Dead cells, migrating cells and proliferating cells of various ploidies. In-vitro results, multi-omics results and similarity between observed and simulated recurrent tumors were used to infer model parameters (resource consumption-, migration-, death and proliferation rates). Running the model backwards in time, we predict the local point of origin (LPO) of each GBM. We found that resource availability in the predicted LPO was correlated to WGD status, suggesting conditions in the local environment in which a GBM originates shape the outcome of an early competition between diploid and tetraploid cells. Citation Format: Noemi Andor. Exploiting interactions between ploidy and host physiology [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 139.
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Abdul-Qadir, Abuhamid M. "The Early Development of Islamic Jurisprudence". American Journal of Islam and Society 14, n.º 3 (1 de outubro de 1997): 83–86. http://dx.doi.org/10.35632/ajis.v14i3.2236.
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Professor Ahmed Hasan has made a great contribution to the understandingof the early history of Islamic jurisprudence up to the time of al Shafi'i (d. 204A.H.). A few works. such as The Origins of Muhammadan Jurisprudence byProfessor Joseph Schacht, have been published on the early development ofIslamic jurisprudence. and Hasan's work is a valuable addition. Islamic jurisprudenceis a dynamic, ongoing, and virtually limitless subject. The communitycannot survive without it as long as new issues arise to be resolved andIslamized. Thi field of study helps the community to move forward, encouragingmembers to solve new problems that arise in their social lives. Hasan discusseshow jurists debate one another over the extraction of God's law and how.ultimately, uch debates have developed Islamic jurisprndence and the differentlegal schools. ljma' (consensus) and qiyas (analogy) did not exist at the time ofthe Prophet; they developed through ijtihtid, based on the principle sources theQur'an and Sunnah. The subject has a kind of progressive flow, tide, and dynamiccharacter. Hasan divide his book into seven chapter, beside an introductionand a concluding discussion. He also includes a bibliography and an index. Theauthor chose a period in the history of jurisprudence for which sources for synthesisare difficult co obcain. He shows the historical development of lslamicjurisprudence in the first two centuries of Hijrah based mainly on the work ofMalik. Abu Yusuf, al Shaybani and al Shafi'i.This book is designed for readers who are particularly interested in Islamiclaw and history. In the introduction the author describes the meaning of fiqh andother allied terms. He analyzes the origins of the early schools of law-such asthe schools of Medina and Iraq-that developed through the work of scholarswho extracted God's law from the revealed sources. Further analysis by theauthor suggests that after the middle of the second century A.H., scholars weregenerally engaged in independent thinking on law. ln the same way. al Shafi'ideveloped his own legal theory and brought consistency into law. After him theregional character of the early schools began to disintegrate and faithfulness toone master and his principles gradually predominated.The author discusses the sources of Islamic law beginning with the developmentof the main five categories of judgment of Muslims' aces, namely, theobligatory. the recommended, the neutral, the disapproved, and the prohibited.These categories are ultimately based on four sources: the Qur'an, the Sunnah,ijma' and qiyas. The author first deal with the Qur'an, briefly pointing out thatit is the primary source of legislation and guidance. The author discusses thedoctrine of the abrogation of individual verses in the Qur'an (naskh) in a separatechapter, pointing out the development of the theory of naskh and its significantrole in Islamic jurisprudence. Although naskh is an established doctrine inthe field of Islamic jurisprudence, the author's long analysis of naskh suggeststhat since the Qur'an is eternal there can be no reasonable ground for the thesis ...
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Schultz, Andrew R., Saeed Alahmari, Pallavi Singh, Zaid Siddiqui, Emily Thomas, Emek Demir, Laura Heiser e Noemi Andor. "Abstract A013: Integrating imaging and sequencing to compute the subcellular organization of a cell’s transcriptome". Cancer Research 82, n.º 10_Supplement (15 de maio de 2022): A013. http://dx.doi.org/10.1158/1538-7445.evodyn22-a013.
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Abstract Background: Incorporation of prior information in the form of pathway activity profiles was key in the success of the algorithm that won the DREAM challenge to predict in vitro cell fitness from transcriptomic and other multi-omic datasets (Costello, C. C et al, 2014). We hypothesize that leveraging additional prior information on the spatial distribution of transcriptome activity inside the cell will yield better predictions of cell fitness, which span longer timeframes. Methods: We integrated (i) sequencing and (ii) imaging data obtained from a stomach cancer cell line (NCI-N87). For (i), we used previously published scRNA-seq data available for 3,246 NCI-N87 cells. Cells were assigned to either G0/G1, S or G2M phase; and G0G1 cells were grouped into subpopulations defined by somatic copy number alterations. In addition, we calculated the pathway activity profile of each cell using gene set variation analysis. For (ii), cells were imaged on a Leica confocal SP8 using 63X objective, collecting 70 z slices of target dye and brightfield with interslice interval 0.29 µm. We trained a previously developed label-free U-Net convolutional neural network (CNN) (Ounkomol, C. et al, 2018) on Z-stacks of images containing the nuclei or mitochondria (mito) to calculate the spatial distribution of the two organelles. Models were trained for nucleus using train (N=37)/test (N=5) and mito using train (N=24)/test (N=5) with the Adam optimizer for 150,000 minibatch iterations monitoring the weighted mean squared error (MSE). The model training pipeline was implemented in PyTorch on a Nvidia DGX A100 Tesla V100 GPU. The accuracy of the model was assessed by calculating the Pearson correlation coefficient between the pixel intensities of the model’s predicted output and the independent test images. The predicted 3D organelles were used as input for segmentation using the Cellpose algorithm (String, C. et al, 2021), giving us nucleus and mito coordinates (X,Y,Z) for each cell. To integrate (i) and (ii) we overlaid the distributions of nucleus and mito area and volume onto the activity of pathways expressed in the nucleus, mito, and their respective membranes. Sequenced and imaged NCI-N87 cells were then co-clustered together to obtain a tree that links profiles between the two assays. Results: Overall, the correlation coefficient (r) was higher when using nucleus images for training (r=[0.759, 0.833]; average 0.780) compared to mito (r=[0.633 - 0.783]; average 0.680), even when the sample sizes were equivalent. Of the imaged cells detected within a given field of view, 50-80% were linked to a sequenced cell. Linking sequenced and imaged cells allows visualizing the spatial distribution of pathway activity among various organelles inside a cell. Conclusions: While our results demonstrate how this can be achieved in principle computationally, they will require extensive experimental validation. Doing so will transform omics-based predictions of cell fitness into problems that can be solved by image classification algorithms and recent advances in computer vision. Citation Format: Andrew R. Schultz, Saeed Alahmari, Pallavi Singh, Zaid Siddiqui, Emily Thomas, Emek Demir, Laura Heiser, Noemi Andor. Integrating imaging and sequencing to compute the subcellular organization of a cell’s transcriptome [abstract]. In: Proceedings of the AACR Special Conference on the Evolutionary Dynamics in Carcinogenesis and Response to Therapy; 2022 Mar 14-17. Philadelphia (PA): AACR; Cancer Res 2022;82(10 Suppl):Abstract nr A013.
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Andor, Noemi, Ana Gomes, Gregory Kimmel, Andriy Marusyk, Richard Beck, Daria Miroshnychenko, Andrew Schultz, Samuel Bakhoum, Philipp Altrock e Thomas Veith. "Abstract A030: Characterizing cytotoxic therapy induced shifts in the cost-to-benefit ratio of high ploidy". Cancer Research 82, n.º 10_Supplement (15 de maio de 2022): A030. http://dx.doi.org/10.1158/1538-7445.evodyn22-a030.
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Abstract Analyses of intra-tumor heterogeneity across multiple cancer types suggest that tumor cell fitness declines once aneuploidy exceeds a certain limit. A significant difference in outcome between tumors above and below the limit however is only evident among therapy-naïve patients, not among patients who subsequently underwent cytotoxic therapy. Our hypothesis is that the context-dependent ambivalence of high ploidy is what accounts for both of these observations. On one hand, high ploidy ameliorates the deleterious effects of missegregation-induced genome-dosage imbalances, on the other hand a high ploidy cell has higher energetic demands as it has to replicate and express more genetic material. We performed a series of in-vitro and in-silico experiments to quantify both, (i) the costs and (ii) benefits of high ploidy. We developed and used mathematical models to predict differences in S phase duration between high and low ploidy cells (i), and to evaluate the possibility of mis-segregation induced population extinction (ii). Model predictions include critical curves that separate viable from non-viable populations as a function of their turnover- and mis-segregation rates. Missegregation- and turnover rates estimated for nine cancer types are then compared to these predictions for various biological assumptions. For (i), we evaluated three key building blocks of dNTP synthesis –PO4, O2 and Glucose– as candidate cell-extrinsic resources that cap ploidy in Glioblastoma and stomach cancers. We predict that at limiting dNTP concentrations, high-ploidy cells will take longer to replicate their DNA than low-ploidy cells. In-vitro experiments support these predictions showing that PO4 depletion imposes a higher fitness cost on near-tetraploid than on near-diploid breast cancer cells. For (ii), the majority of tumors across all nine cancer types had missegregation- and turnover rates that were within viable regions of the parameter space. When a dependency of mis-segregation rate on ploidy was introduced, ploidy states associated with low mis-segregation rates rendered MIE impossible at low turnover rates. Exposing a heterogeneous stomach cancer cell line to the microtubule-targeting drug Vinblastine confirmed that the high ploidy subpopulation had a fitness advantage. If our hypothesis is true, the implications are broad. It would explain vast differences in the extent of inter-tumor karyotype heterogeneity. It may contribute to explain why agents that block dNTP production work well in combination with DNA damaging agents. It would also explain differences in ploidy across different primary and metastatic sites. As solid tumors progress, resources in the tumor microenvironment become scarcer than the resources available in normal surrounding tissues. These resource-poor environments may push high-ploidy cells to leave the primary tumor and thrive at locations with abundant nutrients. Understanding the resource cost of high ploidy can help uncover its therapeutic vulnerabilities across tissue sites with versatile energy supplies. Citation Format: Noemi Andor, Ana Gomes, Gregory Kimmel, Andriy Marusyk, Richard Beck, Daria Miroshnychenko, Andrew Schultz, Samuel Bakhoum, Philipp Altrock, Thomas Veith. Characterizing cytotoxic therapy induced shifts in the cost-to-benefit ratio of high ploidy [abstract]. In: Proceedings of the AACR Special Conference on the Evolutionary Dynamics in Carcinogenesis and Response to Therapy; 2022 Mar 14-17. Philadelphia (PA): AACR; Cancer Res 2022;82(10 Suppl):Abstract nr A030.
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Tagal, Vural, Jackson Cole, Daria Miroshnychenko, Andriy Marusyk e Noemi Andor. "Abstract A024: Ploidy as a predictive biomarker for gemcitabine sensitivity in triple-negative breast cancers". Cancer Research 84, n.º 3_Supplement_2 (1 de fevereiro de 2024): A024. http://dx.doi.org/10.1158/1538-7445.canevol23-a024.
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Abstract The polyploid giant cancer cell (PGCC) state is a common response of cancer cells to various stressors including chemotherapy, irradiation, hypoxia and viral infection. Upon stress, PGCCs adopt an endoreplication in which the genome replicates, mitosis is omitted, and cells grow in size, causing drug resistance. How accessible endoreplication is to a cell, therefore, directly translates to its resistance to therapy. In this study, we hypothesized that endoreplication and PGCC state are more accessible to cancer cells that already have a higher ploidy content prior to therapy. To test this hypothesis, we developed a comprehensive three-tier framework consisting of i) computational, ii) in-vitro and iii) in silico components. First, we designed a set of ordinary differential equations (ODEs) to mathematically model how cells enter and exit the PGCC state in response to a given stressor. We engineered how this in silico approach interacts with in vitro experiments into a broadly applicable software solution called CLONEID. The software uses computer vision to monitor phenotypic changes in cell and nuclear size from standard bright-field microscopy and classify cells into PGCC and non-PGCC states. We used CLONEID to test various therapeutic agents for their ability to select for a stable near-tetraploid (4N) population in a set of near-diploid (2N) cell lines. Through spontaneous cell fusions, we also obtained tetraploid breast cancer cells matched with their parental lines. Altogether, this framework enabled us to i) monitor the PGCC state experimentally in ii) two sets of matched isogenic cell lines with 2N and 4N DNA content to iii) model the successful entry and exit rates to and from the endoreplication state, respectively. As the first application of this framework, we tested the ability of our 2N and 4N TNBC lines (SUM159 and MDA-MB-231) to access the PGCC state upon treatment with 18 chemotherapy agents. Among those drugs, we observed that only gemcitabine caused continued cell growth without cell division in both tetraploid SUM159 and MDA-MB-231 cells whereas near-diploid parental lines were hypersensitive to the treatment. Consequently, tetraploid cancer cells continued to safely grow in the presence of gemcitabine. Furthermore, these PGCCs re-entered the proliferative cell cycle and grew in cell number when treatment is terminated. Gemcitabine-based chemotherapy is a standard treatment for patients with TNBC although its efficacy is limited mainly due to drug resistance. We expect our findings and three-component framework strategy to help stratify the TNBC patient population by their response to gemcitabine. In addition, our mathematical modelling approach has the promising potential to inform personalized dose optimization and to effectively decrease administered gemcitabine dose for a subset of patients, which would alleviate severe therapy-associated side effects and co-morbidities. Citation Format: Vural Tagal, Jackson Cole, Daria Miroshnychenko, Andriy Marusyk, Noemi Andor. Ploidy as a predictive biomarker for gemcitabine sensitivity in triple-negative breast cancers [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: Translating Cancer Evolution and Data Science: The Next Frontier; 2023 Dec 3-6; Boston, Massachusetts. Philadelphia (PA): AACR; Cancer Res 2024;84(3 Suppl_2):Abstract nr A024.
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Marselino, Frendy, Muh Yusuf e Sri Redjeki. "Karakteristik Fisik Habitat Peneluran Penyu di Pulau Gelasa, Kepulauan Bangka Belitung". Journal of Marine Research 13, n.º 2 (2 de maio de 2024): 171–84. http://dx.doi.org/10.14710/jmr.v13i2.39011.
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Penyu merupakan satwa yang termasuk dalam daftar merah satwa yang dilindungi karena populasinya semakin sedikit. Banyaknya perburuan telur,pencemaran alam, hingga perubahan morfodinamika alam mengakibatkan habitat hidupnya menjadi terganggu. Kondisi bentang alam yang kondusif sangat diperlukan untuk meningkatkan populasi penyu, oleh karena itu pengetahuan tentang kondisi fisik habitat yang sesuai untuk peneluran penyu sangat diperlukan. Penelitian ini bertujuan untuk mengetahui karakteristik fisik habitat peneluran penyu di Pulau Gelasa, Kepulauan Bangka Belitung. Karakteristik fisik habitat peneluran terdiri dari karakteristik pesisir hingga laut dan karakteristik sarang penelurannya. Penelitian ini dilaksanakan pada bulan Oktober 2022. Metode yang digunakan adalah metode kuantitatif dan deskriptif dengan data primer meliputi: jumlah dan telur penyu, vegetasi, kemiringan pantai, panjang dan lebar pantai, kedalaman dan diameter sarang, ukuran butir sedimen sarang, pH sarang, suhusarang, dan kelembaban sarang. Sedangkan data sekunder meliputi: data topografi dan batimetri, pasang surut air laut, angin, gelombang laut, dan arus laut. Analisis data berupa korelasi antara beberapa parameter karakteristik fisik habitat peneluran terhadap jumlah telur penyu. Hasil penelitian menunjukkan terdapat tujuh sarang peneluran, diantaranya enam bekas sarang peneluran dan terdapat satu sarang yang terdapat telur. Rata-rata karakteristik fisik habitat peneluran penyu di Pulau Gelasa ini termasuk kurang sesuai untuk peneluran, karena kondisi kelerengan yang agak curam, sehingga sarang menjadi terlalu dekat dengan permukaan air laut. Hubungan antara beberapa karakteristik fisik habitat peneluran penyu yang terukur terhadap jumlah butir telur didapatkan hubungan yang sangat kuat yaitu 96,86% dengan setiap parameter yang tidak signifikan memengaruhi jumlah butir telur. Faktorfaktor yang membuat penyu tetap melakukan peneluran di Pulau Gelasa adalah kondisi alam yang masih terjaga, sehingga penyu laut banyak mencari makan di tempat tersebut, dan yang paling unik adalah penyu memiliki insting untuk kembali ke tempat kelahirannya untuk bertelur. Sea turtles are included in the red list of protected animals because of their smaller populations. The large number of egg hunting, natural pollution, tochanges in natural morphodynamics have resulted in disturbed living habitats.Conducive landscape conditions are indispensable for increasing turtlepopulations, therefore knowledge of the physical conditions of suitable habitats forturtle nesting is indispensable. This study aims to determine the physicalcharacteristics of turtle nesting beach habitats on Gelasa Island, in BangkaBelitung Province. The physical characteristics of the nesting habitat consist of thecharacteristics of the coast to the sea and the characteristics of the nest of itsspawning. This research was conducted in October 2022. The methods used arequantitative and descriptive methods with primary data including: nests and turtleeggs, vegetation, coastal slope, length and width of the beach, depth and diameterof the nest, grain size of the nest sediment, pH of the nest, nest temperature, andnest humidity. While secondary data include: topographic and bathymetric data,tides, winds, ocean waves, and ocean currents. Analysis of correlation data betweenseveral parameters of the physical characteristics of the nesting habitat to turt leeggs. The results showed that there were seven nests, including six former nests andone nest with eggs. The average physical characteristics of turtle nesting habitatson Gelasa Island are not suitable for nesting, because the slope conditions arerather steep, so the nests become too close to sea level. The relationship betweenseveral physical characteristics of turtle nesting habitat that is measured to seaturtle eggs obtained a very strong relationship of 96.86% with each parameter thatdoes not significantly affect sea turtle eggs. Factors that make sea turtles continueto nest on Gelasa Island are the natural conditions that are still maintained, so thatsea turtles are looking for food in that place, and the most unique thing is that seaturtles have an instinct to return to their birthplace to lay eggs.
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Tagal, Vural, Jackson P. Cole, Daria Miroshnychenko, Andriy Marusyk e Noemi Andor. "Abstract LB175: Ploidy as a predictive biomarker for gemcitabine sensitivity in triple-negative breast cancers". Cancer Research 83, n.º 8_Supplement (14 de abril de 2023): LB175. http://dx.doi.org/10.1158/1538-7445.am2023-lb175.
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Abstract Polyploid giant cancer (PGCC) state is a common response of cancer cells to various stressors including chemotherapy, irradiation, hypoxia and viral infection. Upon stress, PGCCs adopt an endoreplication in which the genome replicates, mitosis is omitted, and cells grow in size, leading to resistance. How accessible endoreplication is to a cell, therefore, directly translates to its resistance to therapy. In this study, we hypothesized that endoreplication and PGCC state are more plausible to cancer cells that already have a higher ploidy content prior to therapy. To test this hypothesis, we developed a comprehensive three-tier framework consisting of i) computational, ii) in vitro and iii) in silico components. We designed a set of ordinary differential equations (ODEs) to model how cells enter and exit the PGCC state in response to a given stressor. We engineered how this in silico approach interacts with in vitro experiments into a broadly applicable software solution called CLONEID. The software uses computer vision to monitor phenotypic changes in cell and nuclear size from standard bright-field microscopy and classify cells into PGCC and non-PGCC states. We used CLONEID to test various therapeutic agents for their ability to select for a stable near-tetraploid population in a set of near-diploid cell lines. Through spontaneous cell fusions, we also obtained tetraploid breast cancer cells matched with their parental lines. Altogether, this framework, now, enables us i) to monitor the PGCC state experimentally ii) in matched cell lines with differential DNA content iii) to model the successful entrance and exit rates to and from the endoreplication state, respectively. As the first application of this framework, we tested the ability of our matched triple-negative breast cancer (TNBC) lines (SUM-159 and MDA-MB-231) to access the PGCC state upon treatment with 18 commonly-used chemotherapy agents. We observed that gemcitabine caused continued cell growth without cell division in both tetraploid SUM-159 and MDA-MB-231 cells whereas near-diploid parental cells were hypersensitive to the treatment. Consequently, tetraploid cancer cells continued to safely grow in the presence of gemcitabine. Furthermore, these PGCCs re-entered the proliferative cell cycle and grew in cell number when treatment is terminated. Gemcitabine (GEM)-based chemotherapy is a standard treatment for patients with TNBC although its efficacy is limited mainly due to drug resistance. Moreover, such poor response rate is coupled with severe side effects that frequently leads to the failure of vital organs, serious secondary diseases, and co-morbidities. Our findings suggest that ploidy is a predictive biomarker for gemcitabine sensitivity. Thus, we expect our findings and three-component framework strategy to help stratify the TNBC patient population by their response to gemcitabine. In addition, our mathematical modelling approach has the promising potential to inform personalized dose optimization and to effectively decrease administered gemcitabine dose for a subset of patients, which would alleviate therapy-associated side effects and lethalities. Citation Format: Vural Tagal, Jackson P. Cole, Daria Miroshnychenko, Andriy Marusyk, Noemi Andor. Ploidy as a predictive biomarker for gemcitabine sensitivity in triple-negative breast cancers [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 2 (Clinical Trials and Late-Breaking Research); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(8_Suppl):Abstract nr LB175.
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Ahmad, Waqar. "Islam in a Changing Europe". American Journal of Islam and Society 10, n.º 2 (1 de julho de 1993): 275–77. http://dx.doi.org/10.35632/ajis.v10i2.2517.
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The conference Islam in a Changing Europe was held amid growingconcern about the future of Islamic and other minority conununities inEurope. The organizers, Hafiz Mirza and David Weir (both at the ManagementCentre), Waqar Ahmad, Charles Husband, and Reg Walker (Departmentof Social and Economic Studies), regarded it as opportune forseveral reasons. First, the Gulf War, the tragic situation in Bosnia, and thecontinuing crises throughout Europe and the Middle East are grim buttimely reminders of the tensions pervading European and Islamic relations,despite strong political, social, and economic ties of mutual interest.The impact on European Muslims is of particular concern, as they are thelarge t minority in Europe and thus primary targets of the "new" racism.Second, this precarious position is further affected by the EuropeanCommunity's pursuit of a Single European Market and, ultimately, a unifiedpolity. The large Islamic communities in the EC, the geographicalproximity of the Islamic world, and the "demonization" of Islam in thewe tern media and political imagination rai e the specter of "Europeanness"being defined in contradistinction to "Islam." Rising fasci t attackson minority conununities throughout Europe are the harbinger of dimgersthat must be understood and addressed now. Moreover, these attacks aremerely the overt manifestations of underlying social change in Europe.The implications for Muslims in Europe need to be examined, as they arcpotentially more invidious because of their subtle and subliminal impact.Finally, and symbolically, in marked contrast to the triumphalist celebrationsin Spain and elsewhere, and a a warning that today's racist andfascist attacks on "non-Europeans" have deep-rooted historical antecedents,it is worth recalling that 1992 is also the five-hundredth anniversaryof the European invasion of the Americas, the expulsion of theJews from Spain, and the extinction of the Muslim kingdom of Granada.In sum, the organizers opined that the position of all minorities willbe thrown into harp relief by the European quest for identity as the majoritycultures of the EC (and further afield) seek to integrate. Islamwould perforce act as the "Other" for a variety of reasons. The focus onIslam was not intended to suggest that the consequences of ongoing276 The American Journal of Islamic Social Sciences 102events in Europe for other minorities were insignificant, but that Islambeingon the front line, as it were-could be treated as a metaphor for theserious predicament of all minorities in a changing Europe. With the helpof a contribution of six thousand pounds sterling from CCETSW (theCentral Council for Education and Training in Social Work), the conferencewas convened to examine the many issues relating to "Islam in aChanging Europe" at both the conceptual and the concrete levels.The conference took place over three days. The fitst day looked atbroader conceptual and historical issues, including "The Other as Islam,""Muslim Communities of Europe," and "citizenship and Participation."FolIowing an initial address by Cllr. Mohammed Ajeeb (Deputy Leaderof Bradford Council), the discussion was initiated by five papers: YasminAlibhai-Brown, "Islam in a Changing Europe: Issues of Citizenship andParticipation"; Noshaba Hussain, "Islam in a Changing Europe: An AlternativePerspective"; Hafiz Mim, "Some Reflections on the EuropeanPerimeter"; Haleh Afshar, "Identity Ascribed and Adopted: The Dilemmaof Muslim Women in Europe"; and Ali Hussein, "Culture, Faith and PoliticalIdeology: Islam in an International Context."The second day was devoted to more concrete case studies: education(initiated by Moeen Yaseen's "Islam and the Educational Systems ofEurope," with David Weir acting as discussant); immigration (PaulGordon, "Islam as Europe's Other: Restrictive Immigration Policy as aResponse to the Muslim Presence," with S. I. Ananthakrishan as the discussant);gender and social policy (Sitara Khan, "Muslim Women inBritain: The Lessons of Experience"); and social welfare (Charles Husbandand Waqar Ahmad, "Religious Identity, Welfare and Citizenship:The Case of Muslims in Britain," with David Divine as the discussant).The final day examined practical strategies relating to specific areasof concern via a series of workshops, including ones on education (convener:Abdul Mabud); women (Noshaba Hussain); and participation(Mansur Ansari). In addition, to round off the conference, two views onMuslim futures were presented by Ishtiaq Ahmad and Zaki Badawi.The whole conference was characterized by a forthright openness.Participants disagreed explicitly and at length, and the invited speakerspresented analyses that were partisan and undiluted by euphemism. Yetwhile the discussions were robust and many different positions werevigorously asserted and defended, there was an exceptional lack of personalanimosity. There was a very real sense of dialogue between the participantsand a commitment to sharing both analyses and experience.The mixture of Islamic scholars, community activists, academics, andother interested individuals, as well as of Muslims and non-Muslims,proved to be an important ingredient in facilitating the successful exchangeof perspectives. What may be incapable of retrieval in the bookthat is planned to follow up the conference will be the atmosphere of ...
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Xiao, Lichang. "Basic Principles and Modularity of College English Teaching". Humanistic and Social Seekers, 30 de agosto de 2023, 13–17. http://dx.doi.org/10.61206/hass2023080003.
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The “University English Curriculum Teaching Requirements” promulgated by the Ministryof Education in January 2004 is a win-win document that has been democratically discussed manytimes. This article aims to clarify that the new “Teaching Requirements” embodies contemporaryadvanced concepts from philosophy, linguistics, literary criticism, psychology, pedagogy andother disciplines, such as individualization, collaboration, modularization and hypertextualization. It will have a profound impact on my country's college English teaching, English major teachingand English teaching in primary and middle schools, and promote the reform of foreign languageteaching in our country.
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Hocum Stone, Laura, Cayla Duffy, Tammy A. Butterick, Christopher Holley, Melanie Crampton, Herbert B. Ward, Corey Swingen, Rosemary F. Kelly e Edward O. McFalls. "Abstract 10277: Effect of CoQ10 on Contractile Reserve of Hibernating Swine Myocardium Following Bypass Surgery". Circulation 132, suppl_3 (10 de novembro de 2015). http://dx.doi.org/10.1161/circ.132.suppl_3.10277.
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Background: We have previously shown that the recovery of regional function and maximal oxygen consumption in a pig model of hibernating myocardium is incomplete at 4 weeks following bypass surgery (CABG). Because clinical studies suggest a beneficial effect of chronic administration of Coenzyme Q10 (CoQ10) in ischemic heart disease, we tested the benefit of this supplement on contractile reserve, using MRI. Methods: Twelve pigs underwent placement of a constrictor around the LAD artery and had reduced function by MRI at 12 weeks. They then underwent off-pump byass using a left internal mammary artery graft and were allowed to recover. Pigs were given daily dietary supplements of either CoQ10 (10 mg/kg/day) or placebo and restudied with MRI at 4 weeks post-CABG. Images were acquired prior to and following CABG with a 3.0-T scanner (Achieva, Philips Medical Systems, Andover MA, USA), with a 4-element phased array coil on the chest and EKG gating. Regional circumferential strain (EC) measures were determined at baseline and at the time of the final study post-CABG, during an infusion of low dose dobutamine. Immediately post-stress, blood samples were obtained for analysis of troponins. Results: One animal did not survive and comparisons are made between the Placebo (N=6) and CoQ10 (N=5) groups. At 12 weeks following instrumentation and just prior to CABG, strain in the LAD region of all animals was lower than the remote regions at rest (-14.27±0.65 versus -15.13±0.69 P<0.05). At 4 weeks post-CABG, baseline strain in placebo and CoQ10 groups was -12.4±1.2 and -13.7±0.8 respectively (NS). In addition to no differences in basal function, there were no intergroup differences in either contractile reserve in the LAD region, as measured by circumferential strain, or cardiac troponin levels post-stress (Figure). In summary, in this model of chronic myocardial ischemia, daily supplementation with CoQ10 did not improve basal function or contractile reserve at 4 weeks following CABG.
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Susanto, Aris, Irwandy Tirtawidjaja, Ivan Riyanto Widjaya e Meyselina Iwan. "Correlation between Completeness of Basic Immunization and Other Factors with the Incidence of Acute Respiratory Infection in Toddlers". Jurnal MedScientiae 2, n.º 2 (19 de dezembro de 2023). http://dx.doi.org/10.36452/jmedscientiae.v2i2.3068.
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Acute Respiratory Infection (ARI) is a common disease that occurs in children under five. In developingcountries, the probability of the disease within an age group of toddlers estimated 29% cases perchild/year and in developed countries 5% cases per child / year. It shows that there are 156 millionnew cases per year in the world in which 151 million cases (96.7%) occur in developing countries.Episode cold on Toddlers in Indonesia estimated 2-3 times per year (Rudan et al Bulletin WHO 2008).This study aims to determine the correlation between the comprehensiveness of basic immunization andother factors in terms of ARI on toddler in Cipejeuh Wetan – Cirebon within January to October 2016.The factors that are examined include comprehensiveness of basic immunization, exclusivebreastfeeding, nutrition, smoking behavior in the home. The design study is cross-sectional. Samplingtechnique is cluster random sampling with the primary data source in 62 children under five yearsusing questionnaire. The analysis is Chi-square. The statistical test showed a significant correlationbetween ARI against nutrition (p=0.015), smoking behavior in the home (p=0.009).
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Grapsa, Julia, Timothy C. Tan, David Dawson e Petros Nihoyannopoulos. "Abstract 16108: Right Ventricular Strain is a More Sensitive Marker of Right Ventricular Dysfunction Than Right Ventricular Ejection Fraction in a Cohort of Patients With Idiopathic Pulmonary Arterial Hypertension". Circulation 130, suppl_2 (25 de novembro de 2014). http://dx.doi.org/10.1161/circ.130.suppl_2.16108.
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Introduction: Strain has been shown to be more sensitive that ejection fraction in detecting subclinical dysfunction in the left ventricle. A number of echocardiographic parameters associated with right heart size and function have been shown to be impaired in idiopathic pulmonary arterial hypertension (IPAH) but there is minimal data on which may be the most sensitive. Aim: To characterize the changes in functional and echocardiographic indices of right ventricular (RV) size and function, in a cohort of IPAH patients followed serially to determine if strain is a more sensitive measure of RV dysfunction than RVEF. Methods: Thirty patients (24 women, mean age 46.8 ± 5.3 years) with newly diagnosed IPAH were prospectively recruited and followed with serial transthoracic echocardiograms (TTE; Philips Medical Systems, Andover, MA) 6 monthly for up to 18 months. A range of 2D and 3D echocardiographic measures of right ventricular dimensions and function, including right ventricular ejection fraction (RVEF) and systolic longitudinal strain (LS), was assessed at each time point after commencing treatment using vendor independent software (TomTec, Germany). Functional status was assessed at18 months. Statistical analyses were performed using JMP statistical package (SAS Institute In. Cary, NC) Results: 3D RV volumes, ejection fraction, mass, 2D global strain and 2D free wall strain all show significant changes over 18 months (p-value < 0.05; ANOVA of repeated measures) although peak tricuspid regurgitant velocity, RV systolic pressure and stroke volume do not. However, RV global strain and RV free wall strain showed significant changes within 6 months after diagnosis but not RVEF, peak TR velocity or RVSP. The degree of change in the RV free wall strain change at 18 months but not RVSP, RV mass or RVEF, was also associated with an abnormal 6 min walk test (18 months change, p=0.03). Conclusion: RV global and free wall strain demonstrate significant decreases prior to RVEF, peak TR velocity and RVSP hence may be more more sensitive measures of RV dysfunction in patients with IPAH. These results may help guide treatment decisions and highlight the potential value of echocardiography in detecting subacute cardiac pathology.
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Hinojar Baydes, R., A. Gonzalez-Gomez, A. Garcia-Martin, J. M. Monteagudo, E. A. Rajjoub Al-Mahdi, J. J. Jimenez-Nacher, A. Sanchez-Recalde, J. L. Zamorano e C. Fernandez-Golfin. "Prognostic value of right ventricular systolic function by speckle tracking echocardiography beyond conventional echocardiography in significant tricuspid regurgitation". European Heart Journal 42, Supplement_1 (1 de outubro de 2021). http://dx.doi.org/10.1093/eurheartj/ehab724.0117.
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Abstract Background Right ventricular (RV) systolic function is determinant in the evaluation of patients with significant tricuspid regurgitation (TR). Timely detection of RV dysfunction with conventional 2D echocardiography is limited by the geometry and position of the RV. RV strain has emerged as an accurate and sensitive tool for evaluation of RV function with the capability of detect subclinical RV dysfunction Purpose This study was aimed to evaluate the prognostic value of RV strain in consecutive patients with significant TR, in comparison with conventional parameters of RV systolic function. Methods Consecutive patients in stable clinical status with significant TR (severe, massive or torrential TR) evaluated in the Heart Valve Clinic were included. RV systolic function was measured with conventional echocardiographic parameters (RV fractional area change [FAC], tricuspid annular plane systolic excursion [TAPSE]), DTI S wave (S') and with STE derived automatic peak global and free wall longitudinal strain (GLS, FW-LS respectively) using the EPIQ system (Philips Medical Systems, Andover, Massachusetts). A combined endpoint of hospital admission due to right heart failure or cardiovascular mortality was defined. Results A total of 130 patients were included (mean age was 75±17 years, 69% females, 93% in NYHA I/II). According to etiology, 14% were primary TR and 86% were functional (49% due to corrected left valve disease and 37% due to tricuspid annulus dilatation). Mean values of RV function parameters are shown in the table. During a mean follow up of 18±8 months, n=39 patients (30%) reached the combined endpoint. Patients with events showed impaired RV GLS and FW-LS. Both parameters were predictive of the combined endpoint (table 1). Conventional parameters of RV systolic function were not associated with outcomes (p>0.05 for all). Conclusion In patients with severe TR, RV strain values are superior to conventional parameters to detect RV dysfunction. Among different measurements of RV function, RV GLS and FW-LS were the only predictors of poor prognosis. These parameters should be included in the serial evaluation of these patients. Funding Acknowledgement Type of funding sources: None. RV parameters
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Medenica, Snežana, Maja Račić e Vedrana Joksimović. "Internet and computer addiction: “new age” disease of the 21st century". БИОМЕДИЦИНСКА ИСТРАЖИВАЊА 9, n.º 1 (23 de julho de 2015). http://dx.doi.org/10.7251/bii1501069m.
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The aim of this paper is to give a brief overview of research and the newesttheoretical considerations on internet addiction classification and treatment.Over the past years we have been increasingly facing the so-called “newage” disease of internet addiction as a serious problem affecting numerouspeople, especially the young population who has made social networks andother internet contents a modus vivendi. A literature search was conducted forthe purpose of locating information on prevalence, diagnosis and treatmentof internet and computer addiction. Certain researchers and psychiatristsbelieve that the excessive internet use is a symptom of other disorders, suchas depression and anxiety, or impulse control disorder. However, over thepast few years a consensus has been reached that this constellation of symptomsis actually an addiction disorder. The American Society of AddictionMedicine (ASAM) has recently come up with a new definition, according towhich addiction represents a chronic brain disorder. Consequently, the newAmerican Classification of Mental Disorders (DSM-V) has introduced thisform of addiction under the diagnostic category dubbed “cybernetic disorder”.The field of internet addiction is advancing rapidly through its officialrecognition as a separate and distinct addiction disorder. Some individualswith internet addiction are at significant risk and merit professional care andtreatment. There are several treatments available, but the primary preventionis the most effective intervention. Family practitioners and psychiatrists shouldbe taught to screen their patients for this disorder.
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Lubis, Muhammad Efrizal, e Novdin M Sianturi. "PENETAPAN MODEL BANGKITAN PERGERAKAN UNTUK BEBERAPA TIPE PERUMAHAN DI KOTA PEMATANGSIANTAR". Jurnal Media Teknik Sipil 10, n.º 1 (7 de janeiro de 2013). http://dx.doi.org/10.22219/jmts.v10i1.1210.
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Town expansion not followed by infrastructure development can result many problems andone of them is related to transportation. This research aims to model Trip generation conducted bysome community of housing types in Pematangsiantar town. And the research of this is done toknow and estimate the level of out movement from the housing that will be used for forecasting inorder to overcome all problems at the future period.The primary survey is done by filling thequestionnaire by 86 members of families which are living in three housing type’s area that is luxurious,middle and simple. The result of the questionnaires will be tabulated to become dependent variableand independent variable. Moreover, it will be analyzed by SPSS-12 program. The equation regressionof it will be used to model and awaken the trip of community in some housing types in Pematangsiantartown.From the final result model test, it was gotten that the trip generation in three housing typearea that is luxurious housing type (Y1), middle housing type (Y2), and type housing of simplebuilding (Y3) had been very influenced by amount of family member (X1), amount of the ownershipof car (X3), amount of the ownership of motorcycle (X4) and amount of family go to school (X6).The regression model equations are included by luxurious housing type (Y1) = -0,728 + 1,885 X1+ 0,649 X3 + 0,772 X6, middle housing type (Y2) = 0,600 + 1,300 X1 + 0,900 X3, simple housingtype (Y3) = 0,271 + 1,518 X1 + 0,905 X4.Keyword: Trip generation model, Housing typologies.