Teses / dissertações: "Analyse AVO"

1

Voutay, Olivier. "Mise au point d'attributs sismiques pour l'interprétation AVO et 4D des réservoirs pétroliers par analyse en composantes généralisée". Vandoeuvre-les-Nancy, INPL, 2003. http://www.theses.fr/2003INPL009N.

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Nous proposons d'extraire à partir de données sismiques multicubes de nouveaux attributs sismiques par des analyses en composantes généralisées, résumant les données initiales, tout en gardant un lien clair avec ces dernières et permettant de mettre en évidence toute redondance d'information. Ces nouveaux attributs sont ensuite géologiquement interprétés à l'aide de méthodes statistiques. Dans le cadre AVO, l'apport de l'information sismique avant sommation vis à vis de l'information sismique après sommation est mis en évidence, sur un cas synthétique réaliste, puis sur un cas réel. Dans le cadre 4D, sur un cas réel, la part de non reproductibilité du signal sismique en dehors du réservoir est mesurée, puis les variations du signal au cours du temps au sein du réservoir, suite à son exploitation, sont interprétées. La méthodologie développée a également été adaptée afin de définir un attribut de cohérence, mesurant une similarité locale entre plusieurs cubes sismiques 4D ou AVO.

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2

Tamatoro, Johng-Ay. "Approche stochastique de l'analyse du « residual moveout » pour la quantification de l'incertitude dans l'imagerie sismique". Thesis, Pau, 2014. http://www.theses.fr/2014PAUU3044/document.

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Le principale objectif de l'imagerie sismique pétrolière telle qu'elle est réalisée de nos jours est de fournir une image représentative des quelques premiers kilomètres du sous-sol. Cette image permettra la localisation des structures géologiques formant les réservoirs où sont piégées les ressources en hydrocarbures. Pour pouvoir caractériser ces réservoirs et permettre la production des hydrocarbures, le géophysicien utilise la migration-profondeur qui est un outil d'imagerie sismique qui sert à convertir des données-temps enregistrées lors des campagnes d'acquisition sismique en des images-profondeur qui seront exploitées par l'ingénieur-réservoir avec l'aide de l'interprète sismique et du géologue. Lors de la migration profondeur, les évènements sismiques (réflecteurs,…) sont replacés à leurs positions spatiales correctes. Une migration-profondeur pertinente requiert une évaluation précise modèle de vitesse. La précision du modèle de vitesse utilisé pour une migration est jugée au travers l'alignement horizontal des évènements présents sur les Common Image Gather (CIG). Les évènements non horizontaux (Residual Move Out) présents sur les CIG sont dus au ratio du modèle de vitesse de migration par la vitesse effective du milieu. L'analyse du Residual Move Out (RMO) a pour but d'évaluer ce ratio pour juger de la pertinence du modèle de vitesse et permettre sa mise à jour. Les CIG qui servent de données pour l'analyse du RMO sont solutions de problèmes inverses mal posés, et sont corrompues par du bruit. Une analyse de l'incertitude s'avère nécessaire pour améliorer l'évaluation des résultats obtenus. Le manque d'outils d'analyse de l'incertitude dans l'analyse du RMO en fait sa faiblesse. L'analyse et la quantification de l'incertitude pourrait aider à la prise de décisions qui auront des impacts socio-économiques importantes. Ce travail de thèse a pour but de contribuer à l'analyse et à la quantification de l'incertitude dans l'analyse des paramètres calculés pendant le traitement des données sismiques et particulièrement dans l'analyse du RMO. Pour atteindre ces objectifs plusieurs étapes ont été nécessaires. Elles sont entre autres :- L’appropriation des différents concepts géophysiques nécessaires à la compréhension du problème (organisation des données de sismique réflexion, outils mathématiques et méthodologiques utilisés);- Présentations des méthodes et outils pour l'analyse classique du RMO;- Interprétation statistique de l’analyse classique;- Proposition d’une approche stochastique;Cette approche stochastique consiste en un modèle statistique hiérarchique dont les paramètres sont :- la variance traduisant le niveau de bruit dans les données estimée par une méthode basée sur les ondelettes, - une fonction qui traduit la cohérence des amplitudes le long des évènements estimée par des méthodes de lissages de données,- le ratio qui est considéré comme une variable aléatoire et non comme un paramètre fixe inconnue comme c'est le cas dans l'approche classique de l'analyse du RMO. Il est estimé par des méthodes de simulations de Monte Carlo par Chaîne de Markov.L'approche proposée dans cette thèse permet d'obtenir autant de cartes de valeurs du paramètre qu'on le désire par le biais des quantiles. La méthodologie proposée est validée par l'application à des données synthétiques et à des données réelles. Une étude de sensibilité de l'estimation du paramètre a été réalisée. L'utilisation de l'incertitude de ce paramètre pour quantifier l'incertitude des positions spatiales des réflecteurs est présentée dans ce travail de thèse
The main goal of the seismic imaging for oil exploration and production as it is done nowadays is to provide an image of the first kilometers of the subsurface to allow the localization and an accurate estimation of hydrocarbon resources. The reservoirs where these hydrocarbons are trapped are structures which have a more or less complex geology. To characterize these reservoirs and allow the production of hydrocarbons, the geophysicist uses the depth migration which is a seismic imaging tool which serves to convert time data recorded during seismic surveys into depth images which will be exploited by the reservoir engineer with the help of the seismic interpreter and the geologist. During the depth migration, seismic events (reflectors, diffractions, faults …) are moved to their correct locations in space. Relevant depth migration requires an accurate knowledge of vertical and horizontal seismic velocity variations (velocity model). Usually the so-called Common-Image-Gathers (CIGs) serve as a tool to verify correctness of the velocity model. Often the CIGs are computed in the surface offset (distance between shot point and receiver) domain and their flatness serve as criteria of the velocity model correctness. Residual moveout (RMO) of the events on CIGs due to the ratio of migration velocity model and effective velocity model indicates incorrectness of the velocity model and is used for the velocity model updating. The post-stacked images forming the CIGs which are used as data for the RMO analysis are the results of an inverse problem and are corrupt by noises. An uncertainty analysis is necessary to improve evaluation of the results. Dealing with the uncertainty is a major issue, which supposes to help in decisions that have important social and commercial implications. The goal of this thesis is to contribute to the uncertainty analysis and its quantification in the analysis of various parameters computed during the seismic processing and particularly in RMO analysis. To reach these goals several stages were necessary. We began by appropriating the various geophysical concepts necessary for the understanding of:- the organization of the seismic data ;- the various processing ;- the various mathematical and methodological tools which are used (chapters 2 and 3). In the chapter 4, we present different tools used for the conventional RMO analysis. In the fifth one, we give a statistical interpretation of the conventional RMO analysis and we propose a stochastic approach of this analysis. This approach consists in hierarchical statistical model where the parameters are: - the variance which express the noise level in the data ;- a functional parameter which express coherency of the amplitudes along events ; - the ratio which is assume to be a random variable and not an unknown fixed parameter as it is the case in conventional approach. The adjustment of data to the model done by using smoothing methods of data, combined with the using of the wavelets for the estimation of allow to compute the posterior distribution of given the data by the empirical Bayes methods. An estimation of the parameter is obtained by using Markov Chain Monte Carlo simulations of its posterior distribution. The various quantiles of these simulations provide different estimations of . The proposed methodology is validated in the sixth chapter by its application on synthetic data and real data. A sensitivity analysis of the estimation of the parameter was done. The using of the uncertainty of this parameter to quantify the uncertainty of the spatial positions of reflectors is presented in this thesis

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3

Bertolotti, Antoine. "Traitements locaux des condylomes ano-génitaux externes (revue systématique, méta-analyses, analyse poolée et méta-analyse en réseau²)". Thesis, Antilles, 2019. http://www.theses.fr/2019ANTI0412.

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Contexte: Il existe plusieurs traitements pour les condylomes ano-génitaux externes (CAE) cependant, aucune hiérarchie de traitement claire, n'est mentionnée dans les dernières recommandations. Objectifs: Comparer l'efficacité des traitements topiques et des traitements ablatifs pour la prise en charge des CAE. Méthodes: Tous les essais cliniques comparatifs et randomisés (ECR) de 12 bibliothèques numériques comparant des adultes immunocompétents avec des CAE ayant reçu au moins un traitement administré par le médecin ou auto appliqué par le patient ont été inclus. L’évaluation du risque de biais a suivi les recommandations Cochrane. Le critère d'évaluation de l'étude était la réponse lésionnelle complète (RLC) après évaluation du traitement. Des méta-analyses, des analyses poolées puis une méta-analyse réseau ont été réalisées. Résultats: Soixante-dix ECR (9 931 patients) ont été inclus. Tous les ECR, sauf quatre présentaient un risque élevé de biais. Méta-analyse en réseau: les traitements les plus efficaces comparativement au placebo étaient la chirurgie (RR 10,54 ; IC95% 4,53-24,52), une combinaison de traitement ablatif et d’imiquimod (RR 7,52 ; IC95% 4,53-24,52) et l'électrochirurgie (RR 7,10 ; IC95% 3,47-14,53). Les valeurs de SUCRA confirmaient la supériorité de la chirurgie (90,9%), d’une combinaison d’un traitement ablatif avec de l’imiquimod (79,8%) et de l'électrochirurgie (77,1%). Les TAP les plus efficaces étaient la podophyllotoxine 0,5 % solution (63,5%) et la podophyllotoxine à 0,5 % crème (62,2%). Conclusions: La majorité des ECR inclus sont à faible niveau de preuve. La chirurgie et l'électrochirurgie semblent être supérieures aux autres traitements
Background: While several treatments exist for anogenital warts (AGWs), no clear treatment hierarchy is mentioned in the latest guidelines. Objectives: To compare the efficacy of topical treatments and ablative procedures for the management of AGWs. Methods: Twelve electronic databases were systematically searched. All randomized controlled trials (RCTs) comparing immunocompetent adults with AGWs who received at least 1 provider-administered or patient-administered treatment in at least 1 parallel group were included. Risk of bias assessment followed the Cochrane Handbook. Study endpoints were clearance, recurrence, side effects (SE) and complete lesion response (CLR) after treatment assessment. Meta-analyses, pooled analysis then network meta-analysis were performed. Results: Seventy RCTs (9,931 patients) were included. All but 4 RCTs had a high risk of bias. In network meta-analysis (only CLR assessment): a network geometry was constructed based on 49 of the 70 RCTs. The most efficacious treatments compared to placebo were surgery (RR 10.54; CI95% 4.53-24.52), association of ablative therapy and imiquimod (RR 7.52; CI95% 4.53-24.52), and electrosurgery (RR 7.10; CI95% 3.47-14.53). SUCRA values confirmed the superiority of surgery (90.9%), association of ablative therapy and imiquimod (79.8%), and electrosurgery (77.1%). The most efficacious patient-administered treatments were podophyllotoxin 0.5% solution (63.5%) and podophyllotoxin 0.5% cream (62.2%). Conclusions: Most included RCTs have low-level evidence. Surgery and electrosurgery seem to be superior to other treatments. Combined therapy should be more evaluated in future RCT

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4

Davólio, Alessandra 1980. "Aproximações para os coeficientes de reflexão e analise de AVO". [s.n.], 2006. http://repositorio.unicamp.br/jspui/handle/REPOSIP/307608.

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Orientador: Lucio Tunes dos Santos
Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Matematica, Estatistica e Computação Cientifica
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Resumo: O estudo dos coeficientes de reflexão, de suas aproximações e consequentemente da análise de AVO (do inglês, Amplitude Variation with Offset) desenvolve um papel bastante importante na indústria do petróleo, por auxiliar na descrição litológica da região de interesse. Neste trabalho, inicialmente abordamos as principais idéias envolvidas na dedução das equações dos coeficientes de reflexão PP (ondas P incidente e P refletida) e PS (ondas P incidente e S refletida). Na sequência, são apresentadas diferentes aproximações para estas equações, seguidas de uma análise do comportamento das mesmas quando comparadas entre si e entre suas respectivas expressões exatas. Introduzimos uma nova aproximação para o coeficiente de reflexão PS similar à impedância de reflexão do coeficiente PP proposta recentemente. Finalizamos o trabalho discutindo o conceito de inversão de dados, avaliando a precisão dos indicadores apresentados, e fazendo um breve sumário da tradicional análise de AVO
Abstract: The study of the reflection coefficients, their approximations and the AVO (Amplitude Variation with Offset) analysis plays an important role in the oil industry as they can help to describe the interest region lithology. The first part of this work deals with the main ideas of the deduction of the reflection coefficients PP (P incident and P reflected waves) and PS (P incident and S reflected waves). Then, different approximations for these equations are presented, followed by a discussion of their behavior when compared among them and with their exact expressions. We introduce a new approximation for the reflection coefficient PS similar to the reflection impedance of PP coefficient proposed recently. To conclude, some indicators and their accuracy are discussed and a brief summary about the traditional AVO analysis is presented.
Mestrado
Mestre em Matemática Aplicada

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5

De, Guillen Karine. "Analyse structurale d’effecteurs de Magnaporthe Oryzae impliqués dans la reconnaissance de l’agent pathogène par le récepteur immunitaire du riz RGA5". Thesis, Montpellier, 2016. http://www.theses.fr/2016MONT3502.

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La pyriculariose provoquée par le champignon Magnaporthe oryzae constitue l’une des principales maladies du riz, avec des épidémies récurrentes et très destructrices qui touchent toutes les régions rizicoles. Outre les enjeux économiques et humanitaires liés à cette maladie, le statut de céréale modèle du riz et de champignon parasite modèle de M. oryzae font de l’interaction entre ces deux partenaires un modèle privilégié pour l’étude du contrôle génétique et moléculaire des relations hôte-pathogène. Les protéines effectrices, Avr, de M. oryzae sont sécrétées au cours de l’infection de la plante par ce champignon. Chez certaines variétés de riz ces effecteurs agissent comme des protéines d’avirulence. Elles sont reconnues par les protéines de résistance, R, et induisent une forte réponse de défense dont une mort cellulaire programmée appelée HR (hypersensitive response) à l’origine de la résistance de la plante. L’objectif de cette thèse est de déterminer les structures des protéines Avr, et R et celles des complexes Avr-R. L'analyse structure-fonction permettra d’identifier les domaines et les acides aminés importants pour l'activité des effecteurs et des protéines de résistance. Pour la réalisation de cette thèse, une large gamme de techniques de biologie moléculaire (PCR, clonage moléculaire), de biophysique (Fluorescence) et de biologie structurale (RMN, cristallographie aux RX) disponibles au laboratoire seront utilisées. Du point de vue fonctionnel, ces études devraient apporter de nouveaux éléments sur les fonctions végétales qui sont modulées au cours de l’infection et permettent ainsi à la maladie de s'établir en créant des conditions favorables à la mise en place du processus infectieux
MAGNAPORTHE oryzae causes a devastating disease of rice known as rice blast, affecting all regions cultivating rice. In addition to the economic and humanitarian issues associated with the disease, rice and M. oryzae are widely accepted as models of cereal and fungus for studying genetic control and host-pathogen molecular interactions. The effector proteins, Avr of M. oryzae, are secreted during plant infection by the fungus. In some of the rice cultivation these effectors act as avirulence proteins. They are recognized by resistance proteins R, and induce a strong host response, including programmed cell death known as HR (hypersensitive response) leading to plant resistance. The purpose of the thesis is to elucidate the atomic structures of the proteins Avr, R and Avr-R complexes. Subsequent structure-function analysis will identify domains and important amino acids needed for the activity of the effector and resistance proteins. To carry out this thesis, a wide range of molecular biology techniques (pcr, molecular cloning), biophysics (fluorescence) and structural biology (NMR, X-ray crystallography) will be used. From the functional point of view, these studies will provide insight into mechanisms affecting host functions that are modulated during infection, thus creating favorable conditions for the infection process

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6

Müller, Kai. "Analyse und Verbesserung von iterierter lokaler Optimierung für das Kapazitive Vehicle-Routing-Problem mit Zeitfenstern". [S.l. : s.n.], 2003. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB10952951.

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Fandino, Marino Hernan. "Analise da comunicação sonora no anu-branco guira quira (aves: cuculidae), avaliações eco-etologicas e evolutivas". [s.n.], 1986. http://repositorio.unicamp.br/jspui/handle/REPOSIP/316344.

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Orientador : Jacques Marie Edme Vielliard
Acompanha anexo I, II e III
Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia
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Resumo: Um levantamento do repertório vocal do anu-branco Guira quira em conotação com contextos comportamentais realizado com o intuito de obter uma maior ¿aproximação entendimento de sua estrutura social. Registrou-se o comportamento de vários grupos de anus que residem livremente no Campus da Universidade Estadual de Londrina, no Paraná. Observações também foram feitas de vários anus criados em cativeiro dentro da cidade e numa chácara da região rural suburbana. O viveiro permitiu a complementação e principalmente o detalhamento não só dos registros do comportamento, mas particularmente das gravações do repertório vocal, criando também a especial circunstância de anus livres mas "visitantes" regulares. As gravações foram feitas com um gravador magnetofônico UHER 4000 e microfone acoplado a um refletor parabólico. A análise foi baseada no estudo de sonogramas obtidos a partir das gravações e nas correlações com os contextos comportamentais observados. Os resultados apresentam um repertório de aproximadamente quinze CHAMADOS básicos associados em cinco categorias funcionais e estruturais. A análise e a classificação permaneceram a um nível preliminar devido a várias limitações: o ciclo reprodutivo não foi inteiramente acompanhado e o reconhecimento individual e de sexos permaneceram impossibilitados para o observador, restringindo assim as interpretações dos comportamentos sociais. Discutem-se as fontes ecológicas de seleção das vocalizações, particularmente as características de melhor eficiência de propagação em aves de espaços abertos que, como no anu-branco, implicam numa grande utilização dos parâmetros temporais do som para a codificação das mensagens
Abstract: The vocal repertoire of the Guira Cuckoo Guira guira is described together with its behavioral contexts. The natural groups of Guiras that live at the Campus of the Universidade Estadual de Londrina in Paraná, Brazil, were studied. Important observations and recordings were also obtained from birds raised in captivity in the middle of the town and in the suburban rural area. The latter had special significance because of their effect as lures for the Guira visitors of the neighbourhoods. Recordings were made with a UHER-4000 tape recorder and a microfone on a parabolic reflector. The analyses were made on the basis of the sonagrams obtained and the related behavioral contexts observed. Nevertheless some limitations greatly restricted the interpretations of social behavior, as the observer couldnot follow the whole repro ductive cycle and was unable to recognize the sexes, and in general, the single individuaIs. Ecological sources of selection of vocalizations are discussed. Particularly, it is observed that Guira Cukoos use mainly temporal parameters to code their messages and call from high perches as expected from birds of open habitats. From the biotic point of 'view, the importance of the distance and the possibility for the receiver to localize the sound source have been discussed.
Mestrado
Ecologia
Mestre em Ciências Biológicas

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8

Marques, José Oscar de Almeida 1949. "Ações e causas : um ensaio de analise do conceito de ação intencional". [s.n.], 1988. http://repositorio.unicamp.br/jspui/handle/REPOSIP/281714.

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Orientador : Balthazar Barbosa Filho
Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Filosofia e Ciencias Humanas
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Resumo: Não informado
Abstract: Not informed.
Mestrado
Mestre em Filosofia

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9

Avelino, Marcio Ferreira. "Analise bioacustica e tratamento multimidia do canto do tico-tico Zonotrichia capensis (aves,emberizidae) das populações das regiões entre Campinas e Botucatu". [s.n.], 2003. http://repositorio.unicamp.br/jspui/handle/REPOSIP/284825.

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Orientador: Jacques Marie Edme Vielliard
Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Artes
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Resumo: Nesta pesquisa se analisou os dialetos do Tico-tico Zonotrichia capensis que OCOlTem entres Campinas e Botucatu, estado de São Paulo, Sudeste do Brasil Treze localidades foram visitadas e os cantos de 88 indivíduos gravados com um gravador DAT (Digital Audio Tape) e um microfone cardióide montado em uma parábola acústica. Comparações de sonogramas mostraram a existência de duas áreas onde os cantos foram mais homogêneos, formando dois dialetos. Em 11 localidades, muitos indivíduos compartilham o mesmo tipo de canto. Em seis localidades, houve até cinco tipos de cantos e isto OCOlTeu nas fronteiras dos dialetos. Na região de fronteira também foram encontrados indivíduos que podem cantar mais que um tipo de canto. A similaridade entre os tipos de canto não está relacionada com a distância geográfica entre os cantores. Comparações foram feitas também com gravações de outras localidades do Brasil e similaridades foram encontradas com cantos de aves de localidades distantes, como Conchas e Macururé - Bahia (1810 km)
Abstract: This research analyzed the regiolects of the White-crowned Sparrow Zonotrichia capensis that occur between Campinas and Botucatu, São Paulo state, South Eastem Brazil. Thirteen localities were visited and the songs of 88 individuais recorded with a DAT (Digital Audio Tape) tape-recorder and a cardioid microphone mounted in an acoustic parabola. Comparison of the sonograms showed the existence of two areas where the songs were more homogeneous, forming two regiolects. In 11 localities most individuais shared the same song type. In six localities, there were sang up to 5 different song types; this occurs at the boundary ofthe regiolects. This is also where individuais that can sing more than one song type were found. The similarity between song types is not related with the geographic distance between the singers. Comparisons have been done also with recordings from other Brazilian localities, and similarities have been found with the song of very distant birds, for instance between Conchas and Macururé - Bahia (1810 km)
Mestrado
Multimeios
Mestre em Multimeios

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10

Eliasson, Lars. "Analyses of single-grip harvester productivity /". Umeå : Swedish Univ. of Agricultural Sciences (Sveriges lantbruksuniv.), 1998. http://epsilon.slu.se/avh/1998/91-576-5614-2.gif.

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Huang, Lue. "Analyse de l'efficacité de la régulation par les microARN". Phd thesis, Université Paris Sud - Paris XI, 2012. http://tel.archives-ouvertes.fr/tel-00783064.

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Les microARN constituent une classe de petits ARN non codants d'une vingtaine de nucléotides, issus de transcrits cellulaires, qui inhibent l'expression de gènes cibles au niveau post-transcriptionnel. Chez les mammifères, bien qu'ils puissent agir sur une cible parfaitement complémentaire (mode parfait), les microARN ont presqu'exclusivement des cibles partiellement complémentaires (mode imparfait). Puisqu'en mode imparfait une coupure endonucléolytique de la cible est impossible, il est généralement proposé que le mode imparfait soit moins efficace que le mode parfait : conduisant à un silencing moins efficace, nécessitant plus de complexes effecteurs (miRISC) et facilement saturable par une augmentation du nombre de cible. Dans ce travail j'ai développé une approche expérimentale reposant sur l'expression de protéines fluorescentes pour mesurer précisément le silencing au niveau de chaque cellule. J'ai fait trois observations inattendues sur l'efficacité de la régulation par les microARN : i) le silencing en mode parfait et imparfait nécessite des quantités similaires de petit ARN, ii) une augmentation, même très importante, de l'expression du gène cible ne lui permet pas d'échapper à la régulation, iii) le silencing n'est pas intrinsèquement plus faible en mode imparfait (qu'en mode parfait) mais n'est pas actif dans toutes les cellules. Si les deux premiers points sont facilement explicables dans le cadre de l'induction de la dégradation de l'ARNm cible sur un mode catalytique via la déadénylation de l'ARNm, le troisième indique l'existence d'une régulation forte du silencing qui est spécifique du mode imparfait. De plus, comme dans les deux modes le silencing dépend principalement du même partenaire, Ago2, cette régulation intervient après l'assemblage du complexe minimal (Ago2/petit ARN). Ainsi, les différences entre les modes parfait et imparfait ne se situent pas au niveau proposé puisque lorsque la cellule est compétente, leurs efficacités sont comparables. Par contre, mes travaux mettent en évidence l'existence d'un contrôle de la régulation en mode imparfait dont la nature reste à préciser.

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Hammed, Abdessalem. "Résistance de cible aux antivitamines KR : analyse des conséquences catalytiques de différentes mutations de VKORC1 et, : étude du rôle d’une nouvelle enzyme, la VKORC1L1". Thesis, Lyon 1, 2014. http://www.theses.fr/2014LYO10025/document.

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Les anticoagulants antivitamine K (AVK) sont destinées à limiter la coagulation du sang. Ils sont donc susceptibles de provoquer des saignements. Les AVK ralentissent le cycle de la vitamine K qui est indispensable à la gamma-carboxylation de certaines protéines (PVKD). Les AVK inhibent l'activité vitamine K époxide reductase (VKOR), principalement catalysée par VKORC1. Ce sont des médicaments anticoagulants utilisés chez l'homme. Chez les rongeurs, ils servent de rodonticides. Une résistance aux AVK est observé tant chez l'homme que chez le rongeur.Chez des patients résistants aux AVK, 26 mutations ont été décrites dans la zone codante de VKORC1. L'expression hétérologue de ces enzymes mutées n'a permis de trouver que 6 mutations impliquées dans la résistance. Repérer ces mutations avant le début d'un traitement permettra une mise en place du traitement plus rapide. Les autres mutations ne seraient pas responsables du phénotype observé.La VKORC1L1 a été décrite comme une protéine agissant contre le stress oxydatif. Notre travail confirme que l'enzyme catalyse la réaction VKOR. Si sa participation dans la réduction de la vitamine K époxide est insignifiante dans le foie, il en est tout autrement dans les autres tissus testés. De plus, la VKORC1L1 apparait plus résistante aux AVK par rapport à la VKORC1. Ces propriétés catalytiques de la VKORC1L1 permettent d'expliquer l'absence d'effets des AVK sur les PVKD d'origine extra-hépatiques.Enfin, un travail de mutagénèse dirigée a permis d'abaisser ou d'augmenter considérablement la sensibilité de VKORC1L1 aux AVK. Ces résultats nous permettent de décrire l'implication de différents acides aminés dans l'interaction avec les AVK
Anticoagulant vitamin K antagonists (VKA) are molecules designed to prevent or delay blood clotting. They cause bleeding by slowing the recycling of vitamin K, an essential micronutrient for posttranslational modification of specific proteins (VKDP). It has been shown that VKA specifically inhibit VKORC1 enzyme which catalyze the VKOR reaction. VKA are used as rodenticides to control the proliferation of populations of pest rodents. In humans, they are used in the treatment and prevention of the occurrence of thromboembolic events. Due to the widespread use of these VKA, it was observed a phenomenon of resistance which is essential to better understand for economic, ecological or public health interests. In humans, 25 of 26 mutations were characterized. While these changes have been observed in patients resistant to VKA, the causality of these mutations has been demonstrated for 6 mutations. The ability to detect these changes before the start of treatment will allow the future implementation of the much faster and less expensive. Other mutations are not responsible for the observed phenotype.Moreover, VKORC1L1 has been described as an enzyme whose function is to act against oxidative stress. This study confirms that the enzyme catalyzes the VKOR reaction. If it appears that the liver in its participation in the reduction of vitamin K epoxide is insignificant, it is quite different in other tissues tested. In addition, VKORC1L1 appears more resistant to VKA over the VKORC1. Finally, directed mutagenesis of these residues lead to the decrease or the increase of VKORC1L1 sensitivity to VKA. These data result to the implication of residues in their interaction with VKA

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LIMA, EMMANUEL P. R. "Desenvolvimento e analise de desempenho de ferramentas de aco rapido sinterizadas". reponame:Repositório Institucional do IPEN, 2008. http://repositorio.ipen.br:8080/xmlui/handle/123456789/11762.

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Tese (Doutoramento)
IPEN/T
Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP

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14

Loiseau, Serge. "Etude rétrospective des AVC (accident vasculaire cérébral) en Guadeloupe : analyse de 100 dossiers cliniques". Bordeaux 2, 1994. http://www.theses.fr/1994BOR2M036.

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Bucki, Barbara. "La capabilité de santé des aidants familiaux : analyses du paradigme et pistes d’opérationnalisation". Thesis, Université de Lorraine, 2014. http://www.theses.fr/2014LORR0158/document.

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Le prendre-soin à domicile des personnes atteintes de maladie chronique est de plus en plus assuré par les aidants familiaux, mais leur mode de vie crée un risque pour leur santé. Mener une recherche sur leur capabilité de santé, en d’autres termes sur leur aptitude à adopter un mode de vie favorable à la santé, est d’un intérêt scientifique majeur. L’opérationnalisation de ce paradigme développé en 2010 par Ruger pour comprendre les facteurs du maintien d’un état de santé optimal est au cœur de nos travaux de recherche. A partir d’une collecte de données quantitative menée au Luxembourg et en Lorraine (France), un outil de Capabilité de Santé des Aidants (CSA-20 items) a été élaboré et testé. Il explore huit domaines: santé physique, santé psychologique, valeur accordée au mode de vie, sentiment d’auto-efficacité, soutien familial, capital social, conditions matérielles/sentiment de sécurité, satisfaction à l’égard des informations et des services de soins. Des enquêtes qualitatives complémentaires ont permis de compléter le CSA-20 par 77 items couvrant des domaines tels que la motivation, les compétences psychosociales et les styles de coping. Cet instrument permet d’élaborer des diagnostics personnalisés et d’évaluer des programmes de promotion de la santé. Nos analyses préliminaires ont aussi montré que les répercussions de la maladie chronique sont vécues de manière conjointe dans les dyades aidant-aidé; et que la valeur accordée au rôle d’aidant est favorisée par le soutien venant des professionnels et du réseau social. Pour améliorer la capabilité de santé des aidants, la prise en compte à la fois de leur autonomie et de leur besoin de soutien est dès lors requise
Home care of persons with a chronic disease is increasingly provided by family caregivers, but their lifestyle creates a risk to their health. Therefore, leading a research on their "health capability", in other words, on their ability to adopt a healthy lifestyle is of major scientific interest. The operationalization of this paradigm, developed by Ruger in 2010 to understand the factors of maintaining a state of optimal health, has been the heart of our research. Based on a quantitative data collection conducted in Luxembourg and Lorraine (France), a Health Capability of Family Caregivers instrument (HCFC-20 items) was developed and tested. It explores eight areas: physical health, psychological health, lifestyle value, sense of self-efficacy, family support, social capital, material conditions/sense of security, satisfaction with information and healthcare services. Additional qualitative surveys have completed the HCFC-20 with 77 items covering areas such as motivation, life skills and coping styles. This instrument allows to develop personalized diagnoses and to evaluate health-promoting programs. Our preliminary analyses have also indicated that the impacts of a chronic disease are experienced jointly in patient-caregiver dyads; and the value placed on the role of caregiver is encouraged by the support from professionals and a social network. In order to improve the health capability of caregivers, taking into account both their autonomy and their need for support is therefore required

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Marques, Beatriz Sorrentino. "Sobre a aplicação do conceito de pessoa : uma analise conceitual". [s.n.], 2009. http://repositorio.unicamp.br/jspui/handle/REPOSIP/281980.

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Orientador: Gabbi Junior, Osmyr Faria
Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Filosofia e Ciencias Humanas
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Resumo: A distinção entre pessoas e coisas materiais, para P. F. Strawson em seu livro Individuals, guia a discussão sobre o que são pessoas e como as identificamos e nos referimos a elas. No entanto, a tentativa de fazer esta distinção chama a atenção para a necessidade da reflexibilidade do si mesmo, capaz de identificar si mesmo e outros como sendo pessoas. Paul Ricoeur explicita em seu livro Soi-même comme un autre como a designação de si desenvolve a compreensão da noção de si mesmo. A referência aos particulares de base que auxiliaria em sua distinção de coisas ocorre na linguagem, entretanto, ao levar em consideração atos de fala, que remetem à capacidade de designar a si na interlocução, surge a necessidade de considerar a ação como o principal aspecto que diferencia pessoas de coisas, como Strawson aponta em sua teoria. A ação expõe a distinção entre a espontaneidade com a qual o agente interfere no mundo, por meio de seu corpo, e a ocorrência de eventos de acordo com leis da natureza. Assim, a ação traz a dimensão da ética para o agente ao apontar o seu poder de agir. Por fim, a narrativa ajuda a designar uma ação ao seu agente, pois a ação faz parte da trama que o agente constrói, e contar algo é contar quem fez o que numa história em que o personagem apresenta uma constância. Dadas estas considerações, o presente estudo avalia dois casos de narrativas literárias para constatar se os seres não humanos que as compõem são pessoas ou não
Abstract: For P. F. Strawson, in his book Individuals, the distinction between persons and material things guides the argument over what persons are and how we identify and refer to them. However, tryning to point out the distinction calls atention to the need of the self's reflectivity, capable of identifying onself and another as persons. Paul Ricoeur elucidates in his book Soi-même Comme un Autre how self ascription develops our understanding of the self. The reference to basic particulars that should help distinguishing things happens through language, though, when we consider speech acts, which refere to the self designation capacity in interlocution, we realise the need to consider action as the key aspect which distinguishes persons from things, as Strawson poits out in his theory. Action exposes the distinction between the agente's spontaneous interference in the world, through his body, and the ocurrence of events in acordance with laws of nature. By way of his power to act, action brings to the agent a ethical dimension. Narrative helps ascribing an action to it's agent, since the action is a part of the plot the agent constructs, and to tell something is to tell who did what in a narrative where the character presents constancy. Based on these considerations, the present essay studies two literary cases to decide if the non-human beings preset on these narratives are persons or not. Key Words: Basic Particulars, Oneself, Intentional Action, Self-ascription, Own Body
Mestrado
Filosofia
Mestre em Filosofia

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Salgado, Douglas D'Alessandro. "Modelo estatistico para predição de bem-estar de reprodutoras de frango de corte baseado em dados de ambiente e analise do comportamento". [s.n.], 2006. http://repositorio.unicamp.br/jspui/handle/REPOSIP/257162.

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Orientador: Irenilza de Alencar Naas
Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Agricola
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Resumo: O estudo de reprodutoras de frangos de corte é de grande importância para o país, uma vez que o frango de corte é o terceiro maior item agropecuário em exportação, e o Brasil, o segundo maior exportador do mundo desta carne. O estudo de comportamento de matrizes é de interesse científico, por buscar padrões que possam determinar saúde e bem-estar nessas aves. O galpão de produção deve fornecer um ambiente interno que venha de encontro com as necessidades do conforto térmico das aves. Este trabalho teve como objetivo a implementação de ferramentas e metodologia de análise estatística, que sirva de base para a criação de um sistema de monitoramento eletrônico de comportamento. O trabalho foi desenvolvido com dados coletados em ambiente controlado, utilizando a linhagem Hybro - PG, submetidas a diferentes níveis de temperatura, energia de ração e idade. Os dados foram tabulados utilizando os softwares Minitab@ e SAS@. Foram procedidas as análises descritiva e exploratória e, posteriormente, a modelagem - utilizando as Equações de Estimação Generalizadas (EEG). A pesquisa permitiu o desenvolvimento de modelos estatísticos de simulação e predição de comportamento de matrizes pesadas, que possibilitam a criação de um sistema inteligente para acionamento de sistemas de controle de ambiente em galpões de produção, inclusive com indicativo de bem-estar
Abstract: The study of female broiler breeders is of great importance for the country as broiler production is the third largest export item, and Brazil is the world second largest producer. The study of female breeder behavior is of scientific interest as it searches of specific pattern that may determine health and welfare in those birds. Production housing needs to provide inside environmental conditions that reaches bird's thermal comfort. This research has as objective the implementation of statistical and methodology analysis tools that may contribute to develop a system of electronic behavior monitoring. The experiment was developed with data collected under controlled environmental conditions, using birds from one genetic, and submitted to three distinct levels of ambient temperature, feed energy and age. Data were organized and processes using the software Minitab@ and SAS@. The descriptive, and exploratory analysis were applied, and afterwards the modeling - using the Generalized Estimate Equation. This research allowed the development of simulation statistical models for predicting female broiler breeders behavior, that may permit the building of an expert system for controlling production housing environment, as well as an indicative of welfare
Mestrado
Construções Rurais e Ambiencia
Mestre em Engenharia Agrícola

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Matagrin, Benjamin. "Analyse des causes et des conséquences de la résistance aux anti-vitamines K associée à l’activité Vitamine K époxyde réductase". Thesis, Lyon 1, 2014. http://www.theses.fr/2014LYO10136.

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Le premier axe de ce travail de thèse s'est d'abord orienté vers la détermination des causes biochimiques de la résistance aux AVK liée au polymorphisme du gène Vkorcl. Ainsi, 26 mutations spontanées ont été répertoriées sur le gène Vkorcl chez des hommes recevant des doses augmentées d'AVK. Cependant, l'association entre la résistance et les réelles causes pharmacogénétiques, a parfois été établie de manière un peu hâtive. Nous avons donc, dans un premier temps, voulu confirmer ou non ces liens de causalités, en caractérisant le profile enzymatique de chaque mutant. L'expression hétérologue de ces enzymes mutées, par la levure Pichia pastoris, n'a permis de révéler uniquement 6 mutations réellement impliquées dans le phénotype résistant. De la même manière, nous avons ensuite déterminé l'efficacité d'un nouvel AVK, la Tecarfarine, sur ces mêmes mutants. Cet AVK, contournant toute forme de résistance liée aux polymorphismes des CYP450, présente un avantage relatif face à certaines SNP de Vkorcl. Dans un second temps, nous avons établi les caractéristiques catalytiques d'une nouvelle enzyme paralogue de VKORC1, la VKORC1-L1. Etant également dotée d'une activité vitamine K époxyde réductase, nous voulions éclaircir sont rôle biologique ainsi que sa répartition dans les différents tissus. La VKORC1-L1 apparait alors bien plus résistante aux AVK que VKORC1 malgré une forte homologie de structure. Les propriétés catalytiques de VKORC1-L1 et sa répartition biologique oriente alors sont rôle vers l'activation des PVKD extra- hépatiques, expliquant l'absence d'influence des traitements AVK sur les autres processus vitamine K dépendants. Enfin, grâce à ces résultats, une étude Structure/Fonction de ces 2 enzymes, basée sur la mutagénèse dirigée, nous a permis de révéler certains AA de VKORC1- L1 responsable de son phénotype résistant. Cette étude nous a alors permis de mieux comprendre l'implication de différents acides aminés dans l'interaction avec les AVK chez VKORC1 et VKORC1-L1 et de dévoiler un peu plus leur mécanisme enzymatique. Le deuxième axe de ce travail s'est construit, cette fois-ci, autour des conséquences biochimiques et physiologiques des ces SNP de Vkorcl chez l'homme et le rongeur. Nous avons alors révélé chez le rat des mutations responsables de la perte de vitamine K sous forme de 3-OH au sein du cycle de recyclage. Une explication mécanistique à alors été apportée afin de mieux comprendre cette altération du cycle de recyclage conduisant à terme vers un état de subcarence chez ces animaux. Cet état de subcarence en vitamine K est alors décrit comme le « coût biologique de la résistance aux AVK ». Ce coût biologique va alors avoir des répercussions sur de nombreux processus liés à la vitamine K, comme la calcification des tissus mous mené par la MGP. Nous avons alors tenté de créer un modèle animal, à partir d'une souche de rat possédant une mutation en positon 139 sur Vkorcl causant cette fuite sous forme de 3-OH vitamine K. Ce modèle animal mime parfaitement la calcification au niveau de la média artérielle, de part une simple diminution de l'apport en vitamine K dans l'alimentation, pendant environ 5 semaines. Ces calcifications s'observent dans les artères de multiples organes et reproduisent ce qu'il se manifeste chez les personnes âgées ou souffrant d'IRC. Ce modèle pourra donc à l'avenir supplanter les autres modèles de calcifications artérielles, nécessitant des traitements lourds et une attention toute particulière. Le modèle développé dans cette étude est simple à mettre en place, assez court, peu onéreux et permettra à terme d'étudier des maladies cardiovasculaires comme l'hypertension systolique isolée

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Mellul, Sylvie. "Contribution à l'étude de l'interface Cu-AlO par microscopie électronique en transmission et micro-analyse X". Grenoble 2 : ANRT, 1988. http://catalogue.bnf.fr/ark:/12148/cb37616248k.

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Attal, Yohan. "Analyse des lésions cérébrales ischémiques en phase aiguë, par imagerie par résonance magnétique de diffusion : méthodes, intégration logicielle et évaluations cliniques". Paris 11, 2010. http://www.theses.fr/2010PA112278.

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Dans un premier temps, nous avons développé des techniques de segmentation automatique de l'infarctus à la phase aigue de l' AIC à partir d'images IRM pondérées en diffusion (DWI). Deux méthodes ont été développées avec comme idée directrice, le croisement des informations issues des images DWI et celles de cartographie du coefficient apparent de diffusion (ADC). La première méthode est basée sur des critères d'intensité des images en question, avec une mise en œuvre faisant appel à l'algorithme EM. La seconde méthode intègre en supplément aux données les informations issues d'un atlas probabiliste des lésions attendues suites à un AIC de l'artère cérébrale moyenne. Nous nous sommes ensuite intéressés à l'estimation de la zone à risque de croissance : la pénombre ischémique. La méthode de référence que nous avons utilisée, appelée « NeurInfarct », est basée sur une mesure de disparité (mismatch) entre les mesures d'ADC et de DWI. Dans le cadre d'un tranfert de technologie, j'ai développé une solution logicielle, « NeurInfarct 1. 0. 0 », répondant à des critères d'usage clinique ainsi qu'aux normes qualité des règlementations européennes (CE) et américaines (FDA). La création de ce logiciel a permis la mise en place de plusieurs études cliniques afin d'évaluer ses performances sur de larges bases de données mono et multi centriques, auxquelles j'ai collaboré au tout premier plan. Ces études nous ont permis d'évaluer de manière soutenue les performances des approches méthodologiques proposées et d'envisager des améliorations. Les méthodes d'estimation de la pénombre ischémique à partir de cartes ADC bénéficient également d'informations a priori issues de l'intégration d'un atlas probabiliste des lésions ischémiques
We first developed new automatic image segmentation techniques of the ischemic lesion from diffusion-weighted MRI image (DWI) data acquired at the acute phase. We propose two approaches that both combine DWI data and apparent diffusion coefficient maps (ADC). The first of these segmentation methods isolates the ischemic lesions using a model designed with voxel-intensity criteria and an implementation running the EM algorithm. Indeed, irreversible lesions are revealed by both signaIs of hyper-intensity in DWI images and a relative diminution of the ADC. The second approach complements the imaging data with a probabilistic atlas of the expected lesion territory following an occlusion of the middle cerebral artery. We then worked on the prediction of potential infarct growth and the determination of the so-called ischemic penumbra region. The reference method that was used, called "NeurInfarct", is based on the detection of a regional mismatch between ADC and DWI measures 1 have brought a significant contribution to the technology translation during my thesis: I have developed a software application, « NeurInfarct 1. 0. 0 », complying with the clinical quality standards from European (CE) and American (FDA) regulations. Through this software, several mono and multi centric clinical studies were initiated to evaluate the performances of the approach on larger databases I have contributed and actively collaborated to these studies. This manuscript details the results from two of these studies. Similarly to the segmentation of acute lesions, the methods used for the estimation of the ischemic penumbra from ADC maps benefited from the addition of a priori information extracted from the probabilistic atlas of ischemic lesions

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Leny, Marc. "Analyse et enrichissement de flux compressés : application à la vidéo surveillance". Thesis, Evry, Institut national des télécommunications, 2010. http://www.theses.fr/2010TELE0031/document.

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Le développement de réseaux de vidéosurveillance, civils ou militaires, pose des défis scientifiques et technologiques en termes d’analyse et de reconnaissance des contenus des flux compressés. Dans ce contexte, les contributions de cette thèse portent sur : - une méthode de segmentation automatique des objets mobiles (piétons, véhicules, animaux …) dans le domaine compressé, - la prise en compte des différents standards de compression les plus couramment utilisés en surveillance (MPEG-2, MPEG-4 Part 2 et MPEG-4 Part 10 / H.264 AVC), - une chaîne de traitement multi-flux optimisée depuis la segmentation des objets jusqu’à leur suivi et description. Le démonstrateur réalisé a permis d’évaluer les performances des approches méthodologiques développées dans le cadre d’un outil d’aide à l’investigation, identifiant les véhicules répondant à un signalement dans des bases de données de plusieurs dizaines d’heures. En outre, appliqué à des corpus représentatifs des différentes situations de vidéosurveillance (stations de métro, carrefours, surveillance de zones en milieu rural ou de frontières ...), le système a permis d’obtenir les résultats suivants : - analyse de 14 flux MPEG-2, 8 flux MPEG-4 Part 2 ou 3 flux AVC en temps réel sur un coeur à 2.66 GHZ (vidéo 720x576, 25 images par seconde), - taux de détection des véhicules de 100% sur la durée des séquences de surveillance de trafic, avec un taux de détection image par image proche des 95%, - segmentation de chaque objet sur 80 à 150% de sa surface (sous ou sur-segmentation liée au domaine compressé). Ces recherches ont fait l’objet du dépôt de 9 brevets liés à des nouveaux services et applications rendus opérationnels grâce aux approches mises en oeuvre. Citons entre autres des outils pour la protection inégale aux erreurs, la cryptographie visuelle, la vérification d’intégrité par tatouage ou l’enfouissement par stéganographie
The increasing deployment of civil and military videosurveillance networks brings both scientific and technological challenges regarding analysis and content recognition over compressed streams. In this context, the contributions of this thesis focus on: - an autonomous method to segment in the compressed domain mobile objects (pedestrians, vehicles, animals …), - the coverage of the various compression standards commonly used in surveillance (MPEG-2, MPEG-4 Part 2, MPEG-4 Part 10 / H.264 AVC), - an optimised multi-stream processing chain from the objects segmentation up to their tracking and description. The developed demonstrator made it possible to bench the performances of the methodological approaches chosen for a tool dedicated to help investigations. It identifies vehicles from a witness description in databases of tens of hours of video. Moreover, while dealing with corpus covering the different kind of content expected from surveillance (subway stations, crossroads, areas in countryside or border surveillance …), the system provided the following results: - simultaneous real time analysis of up to 14 MPEG-2 streams, 8 MPEG-4 Part 2 streams or 3 AVC streams on a single core (2.66 GHz; 720x576 video, 25 fps), - 100% vehicles detected over the length of traffic surveillance footages, with a image per image detection near 95%, - a segmentation spreading over 80 to 150% of the object area (under or over-segmentation linked with the compressed domain). These researches led to 9 patents linked with new services and applications that were made possible thanks to the suggested approaches. Among these lie tools for Unequal Error Protection, Visual Cryptography, Watermarking or Steganography

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Atef, Ali Hadi Mr. "ANALYSES OF URSEIS MOHO REFLECTIONS BENEATH THE PREURALIAN FOREDEEP OF THE URAL MOUNTAINS, RUSSIA". University of Akron / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=akron1181569948.

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Fang, Jianxin. "Analyse et algorithmes de résolution de systèmes ATO (Assemble-To-Order) : Applications aux systèmes du type W". Thesis, Ecole centrale de Lille, 2017. http://www.theses.fr/2017ECLI0012/document.

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Nous analysons un type W de système de l’Assemble-à-commande avec des délais de livraison aléatoires, l'arrivée aléatoire de la demande et des ventes perdues, en temps continu. Nous formulons le problème en tant que processus de décision Markov à l'horizon infini. Nous nous éloignons de l'approche standard en caractérisant une région de l'espace d'état où toutes les propriétés de la fonction de coût tiennent. Nous caractérisons la politique optimale dans cette région. En particulier, nous montrons que, dans l'intérieur de la région récurrente, les composants sont toujours produits. Nous caractérisons également la politique d'allocation de composants optimale qui spécifie si une demande de produit arrivant devrait être remplie. Notre analyse révèle que la politique d'allocation optimale est contre-intuitive. Par exemple, même lorsqu'un produit domine l'autre, en termes de coût/taux de vente perdue, sa demande peut ne pas avoir une priorité absolue par rapport à la demande de l'autre produit. Une telle caractéristique n'a pas été observée dans de nombreux paramètres intégrés de production/inventaire où l'allocation d'inventaire suit une priorité fixe pour satisfaire les exigences. Nous montrons également que la structure de la politique optimale reste la même pour les systèmes à production par lots, les temps de production répartis par Erlang et la demande de produits non unitaire. Enfin, nous proposons des heuristiques efficaces qui peuvent être utilisées comme substitut à la politique optimale ou peuvent être utilisées comme une politique de départ pour les algorithmes communs utilisés pour obtenir une politique optimale dans le but de réduire leur temps de calcul
We analyze a W-configuration assemble-to-order system with random lead times, random arrival of demand, and lost sales, in continuous time. We formulate the problem as an infinite-horizon Markov decision process. We deviate from the standard approach by first characterizing a region (the recurrent region) of the state space where all properties of the cost function hold. We then characterize the optimal policy within this region. In particular, we show that within the interior of the recurrent region components are always produced. We also characterize the optimal component allocation policy which specifies whether an arriving product demand should be fulfilled. Our analysis reveals that the optimal allocation policy is counter-intuitive. For instance, even when one product dominates the other, in terms of lost sale cost and lost sale cost rate (i.e., demand rate times the lost sale cost), its demand may not have absolute priority over the other product’s demand. Such a feature has not been observed in many integrated production/inventory settings where inventory allocation follows a fixed priority in satisfying demands. We also show that the structure of the optimal policy remains the same for systems with batch production, Erlang distributed production times, and non-unitary product demand. Finally, we propose efficient heuristics that can be either used as a substitute for the optimal policy or can be used as a starting policy for the common algorithms that are used to obtain the optimal policy in an effort to reduce their computational time

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Metrot, Julien. "Prédicteurs sensorimoteurs de la récupération du membre supérieur après AVC : analyse d'un mouvement d'atteinte et de préhension". Thesis, Montpellier 1, 2013. http://www.theses.fr/2013MON14005/document.

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L'hétérogénéité inter-patients des altérations motrices consécutives aux lésions cérébrales rend nécessaire le besoin d'individualiser la prise en charge du patient après AVC. Afin d'apporter une thérapie adaptée aux besoins du patient au moment opportun, il est nécessaire de prendre en compte plusieurs considérations théoriques afin de comprendre comment la rééducation influence la plasticité cérébrale. La récupération motrice est un phénomène complexe et non-linéaire, et identifier ses composantes caractéristiques est délicat. Au travers d'une étude observationnelle, nous avons investigué la récupération de la fonction motrice en condition unimanuelle (membre non-parétique, parétique) et bimanuelle chez des patients cérébro-lésés en phase subaigüe, sans interférer sur leur programme de rééducation classique. Nous avons d'abord validé l'analyse cinématique pour l'évaluation motrice des mouvements d'atteinte d'objets après AVC, en complément des tests cliniques. L'analyse cinématique permet de fournir des indicateurs de la récupération en temps réel de manière plus sensible que les échelles cliniques. En condition unimanuelle, la récupération du membre non-parétique progresse avant de se stabiliser après 9-10 semaines après AVC. En condition bimanuelle, la dynamique de récupération des coordinations bimanuelles change 6 semaines après AVC. Ces périodes pourraient être des fenêtres temporelles clés à prendre en compte en établissant des protocoles de rééducation. L'identification complète et précise de ces patterns naturels de récupération après AVC pourrait permettre de mieux comprendre les réseaux nerveux spécifiques qui sous-tendent les altérations du membre supérieur. A partir de ces indications cliniques prometteuses, proposer une rééducation adaptée au patient et au meilleur moment devient le challenge des travaux futurs
Poststroke characteristics vary significantly between patients and over time, necessitating the introduction of individualized care. To provide to patients an appropriate and timely therapy, theoretical considerations must be taken into account to understand how a therapy may influence underlying neuroplasticity. Motor recovery is a nonlinear and complex function of time, and identifying its representative features remains intricate. Through observational analysis, we investigated in this thesis the time-related changes in unimanual (nonparetic, paretic upper-limb) and bimanual motor function in subacute poststroke patients, without interfering with standard rehabilitation. Overall, our results firstly validated the relevance of kinematics to assess recovery of reaching movements following stroke, in complement to clinical scores. Kinematics provides accurate real-time indicators of patients' recovery in a more sensitive way to current clinical scales. In unimanual reaching, motor function of nonparetic upper-limb recovered and then leveled off 9-10 weeks poststroke. In bimanual reaching, the dynamic of the recovery pattern of between-hands coordination changed after 6 weeks poststroke. These time-windows might be key periods to consider into designing rehabilitation protocols. Our results contribute to a better understanding of the natural pattern of motor recovery poststroke and could be of interest to understand specific neural network underlying upper-limb impairment. From these promising therapeutic guidelines, next challenge in future research includes tailoring rehabilitation training to patients at the most opportune time

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25

Sandberg, Michelle, e Michael Mayersohn. "Evidenced-Based Analysis of an Herbal Supplement, Procera AVH™ for Cognitive Enhancement". The University of Arizona, 2015. http://hdl.handle.net/10150/614157.

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Class of 2015 Abstract
Objectives: To evaluate evidence – based research on acetyl-L-carnitine (ALC), huperzine – A, and vinpocetine, the active ingredients found in Procera AVH for the treatment of memory loss and to investigate the named “authorities” or other professionals named in advertisements to determine if they are credible, reliable and unbiased sources of information for the treatment of memory enhancement. Methods: A systemic literature review of randomized controlled trials (RCT) was performed, based on predefined search criteria, using the words “memory” and “cognition” with the active ingredients of Procera AVH. The studies evaluated needed to meet certain inclusion criteria in order to be included. Results: Study selection criteria included RCTs conducted on male or female participants of all ethnicities, who were at least 18 years of age. The PubMed search on each of Procera's active ingredients, ALC, vinpocetine and huperzine-A, using the search terms and criteria described, yielded a total of 21 RCTs, but only one of which met all the inclusion criteria. The one study that met the inclusion criteria reported on the effect of ALC on cognition in patients with severe hepatic encephalopathy. Phone calls to KeyView Labs, Inc., the company that sells the product, were unsuccessful in obtaining the information sought. The company representatives stated that they did not have CVs or any other professional biographical information on the developers and promoters of Procera AVH. Conclusions: A search of the scientific literature yielded no evidence that Procera AVH, or any of its individual components listed as being the active ingredients, were effective in improving cognitive or memory function in healthy subjects. No data were found to either support or deny the credibility of those professionals or so-called authorities promoting Procera AVH.

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26

Žunkánová, Barbora. "Ocenění společnosti AVG Technologies N.V". Master's thesis, Vysoká škola ekonomická v Praze, 2017. http://www.nusl.cz/ntk/nusl-358961.

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The aim of this thesis is to estimate the market value of specific company as of 31. 12. 2015 based on Discounted Cash Flow method and Multiples method for potential investors. The thesis is divided into two parts, theoretical part and practical part. The first part describes the basic concepts necessary for valuation of the company and it gives the bases for practical part. The second part is focused on the introduction of the company, strategic and financial analysis and forecasting of value drivers, financial statements and final valuation of the company.

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27

Oliveira, Maria do Socorro. "Contar estorias : um evento de fala em analise, uma visão etnometodologica do ato de narrar". [s.n.], 1994. http://repositorio.unicamp.br/jspui/handle/REPOSIP/270772.

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Orientador: Ingedore G. V. Koch
Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Estudos da Linguagem
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Resumo: Este estudo examina interações narrativas entre crianças em fase de alfabetização e diversos interlocutores-professores, pais e pesquisador -, no intuito de investigar como a criança produz estórias e o entendimento que ela tem deste evento de fala. Para a discussão de ste evento narrra tivo, segu imos os procedimentos de pesquisa da orientação etnometodológica e adotamos, basicamente, as categorias do modelo SPEAKING (Hymes, 1972 ), cuja unidade análise são eventos de fala situadas no tempo e no espaço. A concepção de que narrativas são construções sociais é vista de duas maneiras. Num primeiro sentido, o processo de narrar e os mecanismos utilizados na produção narrativa são examinados em casa e na escola, tentando-se depreender as fontes sociais de letramento em tais ambientes. Com vistas a esta preocupação, foram observadas familias letradas e não-letradas, bem como diversos professores, atuando em atividades narrativas e opinando sobre o ato de narrar. Além da 'observação de rotinas narrativas, foram aplicados questionários e gravados depoimentos. Num segundo sentido, o processo de narrar é analisado como um evento de fala que sofre interferência de inúmeras variáveis. situação, participante!s, propósitos, formas de fala, interpretação, entre outros
Abstract: Not informed.
Doutorado
Doutor em Linguística

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28

Jalal, Naïm. "Caractérisation mécanique et structurelle du muscle squelettique atteint de myopathie spastique post-AVC". Thesis, Paris Est, 2019. http://www.theses.fr/2019PESC0022.

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Dans la phase aiguë suite à un accident vasculaire cérébrale (AVC), les patients sont alités avec le plus souvent les bras repliés sur la poitrine. Certains muscles sont soudainement et souvent pour longtemps, immobilisés en position courte. Ils sont le siège d’une cascade de réactions que l’on nomme myopathie spastique, menant inexorablement à une dégradation de la motricité du patient. L’objectif de ce travail de thèse est de contribuer à la compréhension de cette pathologie en évaluant l’effet de l’immobilisation sur les modifications structurelles et mécaniques de muscles squelettiques lésés. Pour caractériser le comportement mécanique de muscles squelettiques sains et lésés, deux études préliminaires ont été réalisées afin d’investiguer les effets des conditions expérimentales sur les propriétés visco-hyperélastiques du muscle squelettique. Les conditions de conservation des tissus ont ainsi été étudiées en vue de choisir le mode de conservation à privilégier dans le cadre d’essai de relaxation en traction. De plus, une méthodologie par plan d’expérience a été proposée afin de pouvoir étudier l’effet de nombreux facteurs expérimentaux en réalisant peu d’essais de relaxation en traction. Par ailleurs, un modèle animal de rat simulant la myopathie spastique a été proposé. Ce modèle combinant un AVC ischémique et une immobilisation précoce de la patte avant lésée a permis de déterminer les modifications de densités de microconstituants et de comportement mécanique des muscles squelettiques des rats pathologiques en comparaison aux rats sains ou uniquement cérébrolésés/immobilisés. La caractérisation des propriétés mécaniques a été effectuée par une méthode inverse par éléments finis à partir d’essais de relaxation en traction sur muscle entier. Les densités de collagène et les différents types de fibres ont été quantifiés à partir de coupes histologiques grâce à des algorithmes semi-automatiques mis au point durant ce travail de thèse. L’approche a permis de montrer que l’immobilisation est un facteur délétère suite à un AVC. Le modèle animal proposé met donc en évidence certaines modifications structurelles et mécaniques des muscles immobilisés en position courte. La poursuite de ces travaux par une étude longitudinale chez l’animale et une étude translationnelle chez l’homme devrait permettre d’affiner les stratégies thérapeutiques afin de prévenir la cascade de phénomène menant à la myopathie spastique
In the acute phase after stroke, patients are often left supine in bed with their arm folded on the chest. As a result, some muscles remain immobilized in the short position involving a cascade of reactions that we refer to as spastic myopathy, leading to a patient motor function deterioration. The main objective of this thesis is to contribute to the understanding of this muscular disease by evaluating the specific pathological significance of muscle immobilization in the context of stroke. In order to characterize the skeletal muscle mechanical behaviour, two preliminary studies were carried out for purposes of investigate experimental conditions on muscle visco-hyperelastic properties. Conservation conditions were therefore studied in order to choose the conservation method for tensile-relaxation tests. Furthermore, we propose a design of experiment method to study parameter sensitivity while minimizing number of tests. Otherwise, we used rat models to compare four situations: controls, immobilisation of one forelimb without stroke, stroke without immobilization and stroke with immobilisation of the paretic forelimb. We performed blinded measurements of histological parameters, muscle compressibility and visco-hyperelasticity, and overall behavioural testing. Mechanical characterization were carried out by inverse method by finite-element from tensile-relaxation test on whole muscle. Collagenous densities, and diverse fibre type proportions were quantify from histological/immunohistological sections thanks to semi-automatic algorithm developed during this thesis. Within 14 days, immobilisation produced worse contractile tissue atrophy, extracellular matrix fibrosis, connective tissue thickening and alteration of passive mechanical behaviour than stroke, while neurological behaviour was altered similarly to stroke cases in rats with immobilization without stroke. The rat group in whom ischemic stroke and immobilisation of the paretic limb were combined exhibited the worst muscle modifications. Our findings demonstrate that immobilization of skeletal muscle in short position is highly deleterious after stroke. Longitudinal animal studies investigating the precise time course of these changes are required and a translational research should test protocols of muscle hyper-mobilisation in the acute phase of stroke

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29

Widestrand, Johan. "Assessment of trichothecene contamination : chemical aspects and biological methodology /". Uppsala : Swedish Univ. of Agricultural Sciences (Sveriges lantbruksuniv.), 2001. http://epsilon.slu.se/avh/2001/91-576-5808-0.pdf.

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Leboulanger, Christine. "Analyse technométrique des relations ago-antagonistes entre le Japon et les Etats-Unis : cas de l'industrie des matériaux supraconducteurs". Caen, 1993. http://www.theses.fr/1993CAEN0549.

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L'étude "technométrique" portant sur le domaine des matériaux supraconducteurs laisse apparaître de façon significative le caractère de plus en plus international du "phénomène brevet". Les grandes nations industrielles, telles que les Etats-Unis et le Japon, sont de plus en plus portées à protéger leurs techniques et leurs produits nouveaux hors de leur frontières, pour tenter de créer des marchés plus larges. La mondialisation de la technologie, qui transparaît donc avec la supraconductivité, traduit des réalités multiples et complexes semblant devoir être gérées. La stratégie de l'industrie nippone semble être de couvrir l'ensemble du champ industriel tout en concentrant les moyens sur quelques pôles essentiels tandis que celle de l'industrie américaine vise à maintenir un leadership mondial qu'elle sent en passe de lui échapper. Le Japon apparaît comme un pays "d'origine" de la technologie alors qu'un pays traditionnellement très créatif comme les Etats-Unis perd du terrain. Cela traduit une tendance au nivellement entre ces deux pays. Ce travail montre que l'approche ago-antagoniste prédomine dans l'industrie des matériaux supraconducteurs. En effet les intervenants sont à la recherche d'un équilibre entre la compétition et la coopération pour faire face aux spécificités du domaine considéré. Le japon détient un avantage concurrentiel certain sur les Etats-Unis, avantage du aux apports de l'expérience, de la puissance matérielle et organisationnelle.
The "technometric" study focusing on supraconductor materials significantly shows the more and more international nature of the phenomenon of patent. Great industrial nations such as the United-States and Japan get more and more inclined to project their techniques and new products overseas in order to create broader markets. The globalisation of technology - thus appearing with superconductivity - espresses multiple and complex realities which seemingly have to be managed. Apparently the Japanese industrial strategy is to cover the whole industrial field while focusing the means of action on some essential poles. The american indutrial strategy aims keeping a worldwide leadership, which she thinks is on the way to escape her. Japan appears like a country where technology originates while a very creative country such the United-States loses ground. This expresses a tendency to a levelling between both countries. This research shows that ago-antagonism approach prevails in the supraconductor materials industry. In fact the actors are seeking for a balance between competition and cooperation to cope with the specificities of the field concerned

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31

Yang, Can. "Time-lapse Analysis of Borehole and Surface Seismic Data, and Reservoir Characterization of the Ketzin CO2 Storage Site, Germany". Doctoral thesis, Uppsala universitet, Geofysik, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-163013.

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The CO2SINK (and CO2MAN) project is the first onshore CO2 storage project in Europe. The research site is located near the town of Ketzin, close to Potsdam in Germany. Injection started in June 2008, with a planned injection target of 100,000 tonnes of CO2. In February 2011, around 45, 000 tons of CO2 had been injected into the saline aquifer at an approximate depth of 630 m. This thesis focuses on time-lapse analysis of borehole seismic data, surface seismic data and reservoir characterization at the Ketzin site. Baseline Moving Source Profiling (MSP) data were acquired in the borehole Ketzin 202/2007 (OW2), along seven lines in 2007. The zero-offset Vertical Seismic Profile (VSP) data were acquired in the same borehole. The main objective of the VSP and MSP survey was to generate high-resolution seismic images around the borehole. After modeling and data processing, the sandy layers within the Stuttgart Formation can potentially be imaged in the VSP and MSP data whereas reflections from these layers are not as clearly observed in the 3D surface seismic data. 2D and pseudo-3D time-lapse seismic surveys were conducted at the Ketzin site. Interpretation of 2D baseline and repeat stacks shows that no CO2 leakage related time lapse signature is observable where the 2D lines allow monitoring of the reservoir. This is consistent with the time-lapse results of the 3D surveys showing an increase in reflection amplitude just centered around the injection well. The results from the pseudo-3D surveys are also consistent with the 3D seismic time-lapse studies and show that the sparse pseudo-3D geometry can be used to qualitatively map the CO2 in the reservoir with significantly less effect than the full 3D surveying. The 2nd pseudo-3D repeat survey indicates preferential migration of the CO2 to the west. There are no indications of migration into the caprock on either of the repeat surveys. Amplitude Versus Offset (AVO) analysis was performed on both 2D and 3D repeat surveys. A Class 3 AVO anomaly is clearly observed on the 3D repeat data and matches the synthetic modeling well. No AVO anomaly was observed on the 2D repeat data, which was anticipated, but the result shows signs of a pressure response at the reservoir level in the data. Reflection coefficients were calculated using surface seismic data (3D and pseudo-3D) at the site. Pre-injection calculations agree well with calculations from logging data. Post-injection calculations are in general agreement with the seismic modeling, but generally show higher amplitudes than those expected. The full 3D data show a better image of the reflection coefficients before and after injection than the pseudo-3D data and can potentially be used to make quantitative calculations of CO2 volumes. The pseudo-3D data only provide qualitative information.

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32

Musil, Václav. "Analýza AVG signálů". Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2008. http://www.nusl.cz/ntk/nusl-217717.

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The presented thesis discusses the basic analysis methods of arteriovelocitograms. The core of this work rests in classification of signals and contribution to possibilities of noninvasive diagnostic methods for evaluation patients with peripheral ischemic occlusive arterial disease. The classification employs multivariate statistical methods and principles of neural networks. The data processing works with an angiographic verified set of arteriovelocitogram dates. The digital subtraction angiography classified them into 3 separable classes in dependence on degree of vascular stenosis. Classification AVG signals are represented in the program by the 6 parameters that are measured on 3 different places on each patient’s leg. Evaluation of disease appeared to be a comprehensive approach at signals acquired from whole patient’s leg. The sensitivity of clustering method compared with angiography is between 82.75 % and 90.90 %, specificity between 80.66 % and 88.88 %. Using neural networks sensitivity is in range of 79.06 % and 96.87 %, specificity is in range of 73.07 % and 91.30 %.

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33

Richter, Gabriele [Verfasser]. "Hybrid versus alleinige perkutan transluminale Angioplastie (PTA) bei arterieller Verschlusskrankheit (AVK) mit femoro-poplitealen Verschlussprozessen - eine retrospektive Analyse / Gabriele Richter". Ulm : Universität Ulm. Medizinische Fakultät, 2013. http://d-nb.info/1038005248/34.

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Kubík, Ján. "Investície podniku automobilového priemyslu do kovov ako strategických surovín". Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2020. http://www.nusl.cz/ntk/nusl-433261.

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This diploma thesis deals with the fundamental analysis of selected metals as commodities, for use in the production of batteries for electric vehicles, to hedge against changes in the price of physical raw materials. Selected metals are analyzed based on the fundamental parameters, historical price development and the current situation on the commodity market. Based on these fundamental data, a recommendation is formulated for the method of hedging the prices of selected commodities.

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35

Frisch, Jessica. "CHROMATOGRAPHIC AND MASS SPECTRAL ANALYSES OF OLIGOSACCHARIDES AND INDIGO DYE EXTRACTED FROM COTTON TEXTILES WITH MANOVA AND ANO". Master's thesis, University of Central Florida, 2008. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/2699.

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Research was conducted on thirteen 100% cotton denim samples using an acid wash, established by Murray, to extract oligosaccharides from the cellulosic material. The oligosaccharide ion groups (+, +, and +) for molecules with degrees of polymerization between two and seven (DP2-DP7) were analyzed using liquid chromatography coupled to mass spectrometry with an electrospray ionization interface (LC-ESI-MS). The results were compared using the least-squares means in a Multivariate ANOVA (MANOVA) test followed by Univariate ANOVA and Tukey HSD tests and demonstrated that the method could correctly determine that two samples were statistically different 85.9% of the time when analyzing the amount (ng) of each of the oligosaccharide ion groups separately, and 82.0% when analyzing the total moles of monosaccharide units released. A dye extraction was performed on the denim materials and the extract analyzed using gas chromatography coupled with mass spectrometry (GC-MS). Indigo dye was present in all of the denim samples except one. When these results were combined with the two oligosaccharide statistical analyses, the discriminating power was increased to 88.5% and 85.9%, respectively. Additional cellulosic materials were also investigated including four white 100% cotton t-shirts as well as five raw cotton samples grown in Tajikistan, Uzbekistan, Egypt, Iran, and Benin West Africa. The analytical methodology gave results for the white cotton t-shirts and raw cotton samples that were inconsistent with those obtained from the denim samples.
M.S.
Department of Chemistry
Sciences
Forensic Science MS

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36

Bassand, Patrick. "Les apo-dystrophines dans le système nerveux central : analyse régional et développementale. Interactions et rôle potentiel dans l'architecture des synapses glutamatergiques". Université Louis Pasteur (Strasbourg) (1971-2008), 2000. http://www.theses.fr/2000STR13240.

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Bianco-Miotto, Tina. "Loss of ABO antigens in haematological malignancies". Adelaide, S.A, 2002. http://web4.library.adelaide.edu.au/theses/09PH/09phb578.pdf.

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"May 2002" Includes bibliographical references (leaves 229-251) Describes the investigation of the alteration of ABH antigen expression on the surface of red blood cells in patients with haematological malignancies.

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38

Myrberg, Jessica. "Optimering av kolorimetrisk mätmetod i ordinarie verksamhet för analys av litium. : En jämförelse mellan Cobas 6000 och AVL 9180". Thesis, Umeå universitet, Biomedicinsk laboratorievetenskap, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-136570.

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Chenet, Amandine Rome Joanna. "Analyse de la valeur prédictive de la dégénérescence wallérienne diagnostiquée par IRM, sur la récupération motrice après un AVC ischémique résultats préliminaires /". [S.l.] : [s.n.], 2006. http://theses.univ-nantes.fr/thesemed/SPEchenet.pdf.

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Bourin, Marie-Claude. "Thrombomodulin: a novel proteoglycan : studies on structure-function relationships /". Uppsala : Sveriges lantbruksuniv, 1990. http://epsilon.slu.se/avh/1990/91-576-4149-8.gif.

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Ishizuka, Adriele Nayara Dias [UNESP]. "Turnover isotópico do 13C em aves poedeiras". Universidade Estadual Paulista (UNESP), 2014. http://hdl.handle.net/11449/108754.

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Este estudo avaliou o turnover do carbono-13 em sangue e plasma de poedeiras na fase de pré-postura e inicial da postura, pela substituição de dietas C4 por C3 e C3 por C4, utilizando a técnica de isótopos estáveis de carbono. Foram utilizadas 144 aves divididas ao acaso em 2 tratamentos na pré-postura que receberam por 42 dias dietas à base de quireta de arroz e farelo de soja, fosfato bicálcico ou farinha de carne e ossos bovinos. Na fase inicial da postura, as aves dos dois tratamentos da fase de pré postura, foram divididas em quatro tratamentos, consitituídos de dietas à base de milho moído e farelo de soja, fosfato bicálcico ou farinha de carne e ossos bovinos. Aos 1, 2, 3, 5, 7, 10, 14, 19, 25, 32 e 42 de cada fase foram coletados sangue e plasma de 6 aves por tratamento. Os valores de meia-vida do sangue e plasma dos tratamentos ASFB e ASFCO da pré-postura foram maiores (17;4 e 15;5 dias respectivamente) do que os tratamentos ASFB-MSFB; ASFB-MSFCO; ASFCO-MSFB e MSFCO-MSFCO da postura inicial (meias-vidas de 11;10;11 e 9 para o sangue e 2;2;2 e 2 dias para o plasma). Deste modo, pode-se concluir que houve diferença da idade, mas não houve diferença em relação a dieta no turnover do sangue e plasma das aves. Termos para indexação: aves, carbono-13, diluição ...
This study aimed to assess the turnover of carbon-13 on blood and plasma of laying hens by replacing C4 by C3 diets and C3 by C4 diets during the pre-laying period and initial laying period using the technique of stable carbon isotopes. We used 144 laying hens ramdomly divided into two treatments of which were fed by 42 days in the pre-posture period with diets based on rice grits and soybean meal, containing dicalcium phosphate or bovine meat and bone meal. On the beginning of laying period the diets were changed and the poultry of the pre-laying period were divided into four treatments whose diets contained ground corn, soybean meal and dicalcium phosphate; or ground corn, soybean meal and bovine meat and bone meal. On days 1, 2, 3, 5, 7, 10, 14, 19, 25, 32, and 42 of each period the blood and plasma from six birds per treatment were randomly collected. The half-life of blood and plasma of ASFB and ASFCO from pre-laying period were greater (17;4 and 15;5 days, respectively) than the treatments from initial laying period: ASFB-MSFB; ASFB-MSFCO; ASFCO-MSFB e MSFCOMSFCO (half-life of 11;10;11 and 9 for blood, and 2;2;2 and 2 days for plasma. We concluded that the age of hens influenced the blood and plasma turnover whereas the diets did not influenced them ...

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42

Castanho, Simone Braga. "ANÁLISE DE ERROS NO 6º ANO DO ENSINO FUNDAMENTAL: UMA TRANSIÇÃO DO 5º PARA O 6º ANO". Universidade Federal de Santa Maria, 2015. http://repositorio.ufsm.br/handle/1/6758.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Evaluations carried out in Brazil have revealed that the averages of proficiency in Mathematics have been continuing low in both national and state exams. The influence of teachers training over students learning has been investigated and, generally, it is accepted that problems on training have negative effects over students learning at basic education. Taking into consideration the difficulties in Mathematics and the low averages on official exams, such as SAEB (Brasil, 2005), presented on students learning from the elementary school system of the city of Santa Maria, this research has been carried out based on assumptions from analysis of errors in a public school from this city with 6th graders. From the analysis of students answers, on tests applied by the teacher of two classes, the most common errors were analyzed, classified and grouped. Then, teaching strategies were elaborated from those errors. Soon after the application of the strategies, we applied a new test in order to observe the impact of these strategies on the learning of such contents. With the results, we set teaching workshops for teachers from grades previous to the sixth grade, a questionnaire about the workshops for the participating teachers was applied as well. We think that we have contributed for the teaching of mathematics in that school besides helping with the teaching practice through workshops for teachers and with activities for students, such as games, which helped contemplate the discrepancies in the teaching of mathematics from the errors observed.
As avaliações, em larga escala, realizadas no Brasil têm revelado que as médias de proficiência em Matemática vêm se mantendo baixas, tanto nas provas nacionais como estaduais. A influência da formação do professor sobre a aprendizagem dos alunos tem sido investigada e, em geral, é aceito que problemas na formação têm efeitos negativos sobre a aprendizagem dos estudantes da escola básica. Tendo em vista as dificuldades na disciplina de Matemática e as baixas médias nos exames oficiais, como o SAEB (BRASIL, 2005), apresentadas na aprendizagem de alunos do Ensino Fundamental do município de Santa Maria, realizou-se esta pesquisa fundamentada em pressupostos de Análise de Erros, numa escola da rede pública desta cidade com alunos do 6º ano do Ensino Fundamental. Por meio da análise das respostas dos alunos, em provas aplicadas pela professora regente de duas turmas, foram analisados, classificados e agrupados os erros mais comuns cometidos, sendo que a partir destes foram elaboradas estratégias de ensino. Logo após a aplicação das estratégias aplicou-se uma nova prova a fim de observar o impacto das mesmas sobre a aprendizagem de tais conteúdos. Com os resultados foram preparadas oficinas de ensino aos professores das séries anteriores ao sexto ano. Aplicou um questionário sobre as oficinas a estes professores participantes. Julgou-se ter contribuído para o ensino de Matemática desta escola, bem como auxiliou a prática docente, através de oficinas aos professores e com atividades para os alunos, como jogos, que ajudaram a contemplar as defasagens no ensino de Matemática a partir dos erros observados.

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43

Moinard, Matthieu. "Codage vidéo hybride basé contenu par analyse/synthèse de données". Phd thesis, Telecom ParisTech, 2011. http://tel.archives-ouvertes.fr/tel-00830924.

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Les travaux de cette thèse sont destinés à la conception d'outils algorithmiques permettant d'accroître le facteur de compression des standards actuels de codage vidéo, tels que H.264/AVC. Pour cela, une étude préalable portant sur un ensemble de méthodes de restauration d'image a permis d'identifier et d'inspecter deux axes de recherche distincts. La première partie est fondée sur des méthodes d'analyse et de synthèse de texture. Ce type de procédé, aussi connu sous le nom de template matching, est couramment utilisé dans un contexte de codage vidéo pour prédire une portion de la texture de l'image suite à l'analyse de son voisinage. Nous avons cherché à améliorer le modèle de prédiction en prenant en compte les spécificités d'un codeur vidéo de type H.264/AVC. En particulier, la fonction débit/distorsion utilisée dans les schémas de codage vidéo normatifs se base sur une mesure objective de la qualité. Ce mécanisme est par nature incompatible avec le concept de synthèse de texture, dont l'efficacité est habituellement mesurée selon des critères purement perceptuels. Cette contradiction a motivé le travail de notre première contribution. La deuxième partie des travaux de cette thèse s'inspire des méthodes de régularisation d'image basée sur la minimisation de la variation totale. Des méthodes ont été élaborées originellement dans le but d'améliorer la qualité d'une image en fonction de la connaissance a priori des dégradations qu'elle a subies. Nous nous sommes basés sur ces travaux pour concevoir un modèle de prédiction des coefficients transformés obtenus à partir d'une image naturelle, qui a été intégré dans un schéma de codage vidéo conventionnel.

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44

Luiz, Aline Godoi [UNESP]. "Alimentação do lactente com fissura labiopalatina no primeiro ano de vida". Universidade Estadual Paulista (UNESP), 2017. http://hdl.handle.net/11449/150423.

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Objetivo: Analisar a história alimentar e a experiência materna com a amamentação de lactentes com fissura labiopalatina. Método: estudo descritivo, transversal, de dupla abordagem: quantitativo e qualitativo, realizado no ambulatório de um hospital de referência. Os dados foram coletados por meio de entrevistas estruturadas com 150 mães; 6 mães participaram do estudo qualitativo. Foram realizadas análises de regressão logística univariada e múltipla, adotando-se como critério para inclusão no modelo múltiplo p≤0,20. Para considerar um fator como associado ao desfecho foi considerado p crítico <0,05, na análise múltipla. Essas análises foram realizadas no programa SPSS. Para a abordagem qualitativa a amostra foi selecionada por conveniência. Os depoimentos das mães foram analisados segundo o referencial da análise de conteúdo de acordo com os passos propostos por Graneheim e Lundman. Após a análise das entrevistas qualitativas, os depoimentos foram categorizados em temas e subtemas. Resultados: Menos da metade das mães souberam do diagnóstico da fissura no pré-natal e esse fator associou-se com o aleitamento materno exclusivo na primeira semana de vida, sendo o médico o responsável pelas orientações no pré-natal. O tipo de fissura prevalente foi o transforame incisivo unilateral e sobre o estado nutricional, prevaleceu a eutrofia. Foi constatado também, através das análises do conteúdo latente, as fortalezes, dificuldades e desafios frente ao nascimento de um filho com fissura labiopalatina Conclusão: evidenciou-se a importância da orientação dos profissionais de saúde e da época de descoberta do diagnóstico da fissura, facilitando assim o processo de enfrentamento e o aleitamento materno. Demonstra-se a necessidade da capacitação prévia de todos os profissionais que irão atuar no pré e pós-natal.
Objective: To analyze feeding history and maternal experience with breastfeeding infants with cleft lip and palate. Method: descriptive, cross - sectional, double - approach study: quantitative and qualitative, performed at the outpatient clinic of a reference hospital. Data were collected through structured interviews with 150 mothers; 6 mothers participated in the qualitative study. Univariate and multiple logistic regression analyzes were used, adopting as criterion for inclusion in the multiple model p≤0.20. To consider a factor as associated to the outcome, p was considered critical <0.05, in the multiple analysis. These analyzes were performed in the SPSS program. For the qualitative approach the sample was selected for convenience. The statements of the mothers were transcribed in their entirety and analyzed according to the theoretical framework of content analysis according to the steps proposed by Graneheim and Lundman. After analyzing all the qualitative interviews, a framework was constructed with the themes found from the testimonies, being categorized in themes and sub-themes. Results: Less than half of the mothers knew of the prenatal diagnosis and this factor was associated with exclusive breastfeeding in the first week of life, the physician was responsible for the prenatal guidelines. The prevalent type of fissure was unilateral incisive transforamen and on nutritional status, eutrophy prevailed. The strengths, difficulties and challenges faced by the birth of a child with cleft lip and palate were also verified through latent content analysis. Conclusion: the importance of the guidance of health professionals and the time of discovery of the diagnosis of fissure was evidenced, facilitating thus the coping process and breastfeeding. It demonstrates the need for prior training of all the professionals who will work in the pre- and post-natal period.

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45

Magnusson, Margareta. "Soil pH and nutrient uptake in cauliflower (Brassica oleracea L. var botrytis) and Broccoli (Brassica oleracea L. var. italica) in northern Sweden : multielement studies by means of plant and soil analyses /". Umeå : Swedish Univ. of Agricultural Sciences (Sveriges lantbruksuniv.), 2000. http://epsilon.slu.se/avh/2000/91-576-5750-5.pdf.

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46

Wojciechowski, Elizabeth. "Personalised orthotic therapy using 3D printing in children with Charcot-Marie-Tooth disease". Thesis, University of Sydney, 2020. https://hdl.handle.net/2123/23718.

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Children with Charcot-Marie-Tooth disease (CMT), are often prescribed custom-made ankle-foot orthoses (AFO) to manage walking difficulty. These externally worn assistive devices are usually handmade using a plaster cast of the patient's lower limb followed by thermoplastic vacuum forming. This traditional approach is labour-intensive and provides limited design options, resulting in AFOs which are cumbersome and associated with low acceptability, discomfort and suboptimal biomechanical function. The aim of this PhD Thesis was to develop, redesign and evaluate 3D printed AFOs compared to traditional handmade AFOs for children with CMT. A systematic literature review revealed that 3D printing AFOs has many potential benefits over traditional methods, including the development of novel designs that optimise stiffness and energy dissipation, improve gait, comfort and fit. The relationship between functional ability in 60 children with CMT and associated gait deviations using 3D gait analysis was assessed. The results showed that not all children with CMT have the typically described foot drop, push-off deficit and ‘steppage gait’ pattern. Instead, three distinct gait patterns exist at the ankle, indicating patient-specific orthotic design pathways. In 12 children with CMT, traditional handmade AFOs, replicated and iteratively redesigned 3D printed AFOs were compared to a shoe only condition using 3D gait analysis, in-shoe pedobarography and a patient satisfaction scale. Replicated 3D printed AFOs were comparable to traditional AFOs for all gait outcomes and patient satisfaction scores. Iteratively redesigned 3D printed AFOs reduced mass by, on average, 35% and improved ankle plantarflexion angle during the push-off phase of gait by up to 7°. The design, gait and acceptability of traditionally handmade AFOs can be replicated and redesigned with 3D printing in children with CMT.

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47

Bianco-Miotto, Tina. "Loss of ABO antigens in haematological malignancies / Tina Bianco-Miotto". Thesis, Adelaide, S.A, 2002. http://hdl.handle.net/2440/21857.

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"May 2002"
Includes bibliographical references (leaves 229-251)
xv, 251 leaves : ill. (some col.) ; 30 cm.
Describes the investigation of the alteration of ABH antigen expression on the surface of red blood cells in patients with haematological malignancies.
Thesis (Ph.D.)--University of Adelaide, Dept. of Medicine, 2003

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48

Luiz, Aline Godoi. "Alimentação do lactente com fissura labiopalatina no primeiro ano de vida". Botucatu, 2017. http://hdl.handle.net/11449/150423.

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Orientador: Maria Antonieta de Barros Leite Carvalhaes
Resumo: Objective: To analyze feeding history and maternal experience with breastfeeding infants with cleft lip and palate. Method: descriptive, cross - sectional, double - approach study: quantitative and qualitative, performed at the outpatient clinic of a reference hospital. Data were collected through structured interviews with 150 mothers; 6 mothers participated in the qualitative study. Univariate and multiple logistic regression analyzes were used, adopting as criterion for inclusion in the multiple model p≤0.20. To consider a factor as associated to the outcome, p was considered critical <0.05, in the multiple analysis. These analyzes were performed in the SPSS program. For the qualitative approach the sample was selected for convenience. The statements of the mothers were transcribed in their entirety and analyzed according to the theoretical framework of content analysis according to the steps proposed by Graneheim and Lundman. After analyzing all the qualitative interviews, a framework was constructed with the themes found from the testimonies, being categorized in themes and sub-themes. Results: Less than half of the mothers knew of the prenatal diagnosis and this factor was associated with exclusive breastfeeding in the first week of life, the physician was responsible for the prenatal guidelines. The prevalent type of fissure was unilateral incisive transforamen and on nutritional status, eutrophy prevailed. The strengths, difficulties and challenges faced by the birth ... (Resumo completo, clicar acesso eletrônico abaixo)
Mestre

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49

Mocnik, Arianna. "Processing and analysis of seismic reflection data for hydrocarbon exploration in the plio-quaternary marine sediments". Doctoral thesis, Università degli studi di Trieste, 2012. http://hdl.handle.net/10077/7763.

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2010/2011
RIASSUNTO Durante i tre anni di Dottorato di Ricerca sono state studiate ed applicate delle specifiche tecniche di analisi del segnale sismico a riflessione mirate alla identificazione di livelli di idrocarburi all’interno di sedimenti marini Plio-Quaternari. Particolare attenzione è stata inoltre dedicata alla correlazione tra questi reservoir di idrocarburi e le strutture geologiche profonde che ne possono aver favorito l’accumulo. Le metodologie utilizzate sono costituite da: 1) metodi diretti, chiamati Direct Hydrocarbon Indicators, che si basano sull’osservazione delle caratteristiche acustiche di un riflettore legato a gas; 2) metodo AVO-Amplitude Variation with Offset, che si basa sull’analisi delle variazioni delle ampiezze di riflessione in funzione dell’offset, fortemente dipendente dalla presenza di idrocarburi; 3) calcolo degli attributi sismici, grazie al quale è possibile estrarre dall'onda sismica informazioni supplementari non direttamente evidenziate nei profili sismici standard osservabili dal dato originale, che contribuiscono a verificare la presenza di gas. E’ questo il caso analizzato nel Canale d’Otranto: lungo il profilo sismico MS-29 si sono riscontrate evidenze di possibili accumuli di idrocarburi all’interno della sequenza Plio-Quaternaria; gli attributi sismici sono stati applicati al bright spot osservato, sia in fase pre-stack che in fase post-stack; il metodo è risultato fondamentale per individuare le caratteristiche di ampiezza, fase e frequenza che caratterizzano un riflettore legato a idrocarburi. L’analisi AVO, ha consentito di rinvigorire l’ipotesi di un livello saturo a gas. Il bright spot osservato è ubicato in corrispondenza del margine della piattaforma carbonatica Apula. Questa avrebbe costituito l’elemento strutturale all'origine della deformazione dei sedimenti in una blanda anticlinale: in essa sarebbero stati intrappolati gli idrocarburi grazie allo sviluppo di fenomeni di compattazione differenziata tra i sedimenti di copertura di bacino e di piattaforma. Anche in Adriatico Centrale l’analisi di un possibile livello a gas lungo il profilo sismico ADRIA-95 ha fatto supporre l’esistenza di orizzonti saturi a gas all’interno della serie sabbiosa-argillosa Plio Quaternaria. In questo caso è stato effettuato l’analisi del bright spot mediante attributi sismici e AVO, i quali hanno confermato l’ipotesi. Oltretutto, sul dato sismico è stato eseguito il re-processing mirato alla definizione delle unità sedimentarie che caratterizzano la sequenza Post-Messiniana dell’area attraversata dal profilo. Sulla base dei risultati ottenuti è stato proposto l’utilizzo degli attributi per il miglior riconoscimento delle geometrie degli strati, da cui si è potuta affinare l’interpretazione dell’assetto geologico. Si è osservato nel dettaglio che l’evidenza di gas risulta collocata in corrispondenza di strati deformati da spinte profonde legate a domi salini triassici. Oltre a questi casi di studio, sono state effettuate delle analisi di possibili livelli saturi in gas riconosciuti lungo profili sismici ubicati nel Bacino Mediterraneo, in particolare nell'offshore della Sardegna Occidentale, nel Canale di Sicilia e nel Bacino Levantino. AVO e attributi sismici sono serviti a validare l’ipotesi di presenza di idrocarburi nei sedimenti Plio-Quaternari, valutando le correlazioni ai diversi contesti geologici in cui si sono impostati. L’effetto delle procedure è stata anche testata al caso specifico dei gas-idrati, con l’obiettivo di definire se un riflettore individuato lungo un profilo sismico della Penisola Antartica, potesse essere un bottom simulating reflector (BSR); questo rappresenta la tipica manifestazione sismica di gas idrato. Le procedure di AVO sono risultate efficaci anche in presenza di idrocarburi che si trovano in specifiche condizioni di temperatura, pressione e composizione. Le medesime procedure di analisi del segnale sismico sono state quindi applicate a dati che furono acquisiti con diverse sorgenti, modalità di registrazione e geometrie di acquisizione, in funzione dei diversi target da raggiungere. Grazie a ciò è stato possibile fare un confronto tra le varie risposte del metodo a questi “parametri" e giudicare le condizioni del dato originale che consentono di ottenere i risultati più soddisfacenti. L'insieme delle analisi effettuate conferma l'utilità di un approccio sempre più avanzato di analisi AVO e di Attributi Istantanei via via più complessi. Suggerisce inoltre l'opportunità di correlare la presenza di idrocarburi agli elementi geologici presenti, riconoscibili attraverso una accurata interpretazione del dato sismico.
ABSTRACT During the three years of the PhD course specific techniques of analysis of seismic reflection data have been studied and applied, aimed at identifying the hydrocarbon saturated levels within Plio-Quaternary marine sediments. Particular attention was also devoted to the correlation between these hydrocarbon reservoirs and some deep geological structures that have favored their accumulation. The used techniques consist of: 1) direct methods, called Direct Hydrocarbon Indicators, which are based on observation of the acoustic characteristics of a gas-related reflector; 2) AVO Amplitude Variation with Offset method, which is based on the analysis of amplitude variations as a function of the offset, strongly influenced by the presence of hydrocarbons; 3) estimation of seismic attributes, from which additional information, not directly evidenced in standard seismic data, can be extracted from the reflected wave, thus contributing to verify gas presence. A first case study has been analyzed in the Otranto Channel: evidences of possible hydrocarbon accumulations along the seismic profile MS-29 have been shown within the Plio-Quaternary sequence. Seismic attributes have been applied to the observed bright spots in both pre-stack and post-stack data; the method has resulted essential to identify the characteristics of amplitude, phase and frequency parameters, that usually contribute to define an hydrocarbon related reflector. AVO analysis has allowed to strengthen the hypothesis of a gas filled layer. The studied bright spots is located over the margin of the Apulia Carbonate platform. This would represent the structural feature at the origin of the sediments deformation in a gentle anticline: here, the hydrocarbons would be trapped due to the development of differential compaction phenomena between the sediments covering the basin and the platform. A possible gas saturated level identified along the seismic profile ADRIA-95 in the Central Adriatic suggested the existence of another reservoir within the Plio-Quaternary sediments. In this case study, the analysis of the bright spots has been achieved with application of seismic attributes and AVO, which have confirmed the hypothesis. Furthermore, re-processing of the seismic data was performed, aimed at the definition of the sedimentary units that characterize the post-Messinian sequence of the area. Based on the obtained results, the attributes analysis were also applied to the improvement of definition of the strata geometries: this allowed the refining of the interpretation. It has been observed, in detail, that the evidence of gas is placed in correspondence of deformed layers by pressures derived from deep Triassic salt domes. In addition to these case studies, some other analysis have been performed after the recognition of possible gas saturated horizons along seismic profiles located in the Mediterranean Basin, especially offshore of West Sardinia, Sicily Channel and in the Levantine Basin. AVO and seismic attributes have been used to validate the hypothesis of the presence of hydrocarbons in Pliocene-Quaternary sediments, also considering the correlations to the different geological contexts in which they are set. Finally, the effect of these procedures was also tested for gas-hydrates, with the aim of defining if a reflector observed along a seismic profile of the Antarctic Peninsula, could be a bottom simulating reflector (BSR), that represents the typical seismic manifestation of gas hydrate. The procedures for AVO are found to be effective even in the typical conditions of temperature, pressure and composition related to the BSRs. The same procedures of seismic signal analysis have been applied to data that were acquired with different sources, recording mode and acquisition geometries, depending on the different target to be reached. Thanks to that, the comparison among the different responses of the methods to these "parameters" has been possible, evaluating the conditions of the original data that could produce the most satisfactory results. All the applied methods confirm the utility of a more and more advanced approach for analysis of AVO and instantaneous attributes increasingly complex. It also suggests the opportunity to correlate the presence of hydrocarbons presence with the geological elements, identified through a rigorous seismic data interpretation.
XXIV Ciclo
1982

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Tamanaha, Eduardo Kazuo. "Um panorama comparativo da Amazônia no ano 1000". Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/71/71131/tde-18012019-150326/.

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Nesta tese buscou-se esboçar um cenário das ocupações ceramistas pré-coloniais, entre 600 e 1.400 DC, na região da Amazônia brasileira. Através do banco de dados georreferenciado foram realizadas análises correlacionando diferentes aspectos que compõem o sítio arqueológico, possibilitando a identificação de mudanças ou continuidades de determinadas sociedades em escala regional. Ao final percebeu-se que algumas áreas possuíam maior trânsito de pessoas e ideias do que outras regiões, refletindo em diferentes níveis de variabilidade observadas no contexto arqueológico.
This thesis sought to outline a scenario of precolonial ceramic occupations, between 600 and 1400 AD in the Brazilian Amazon region. Through the georeferenced database, analyzes were carried out correlating different aspects that make up the archaeological site, allowing the identification of changes or continuities of certain societies on a regional scale. At the end it was realized that some areas had greater movement of people and ideas than other regions, reflecting different levels of variability observed in the archaeological context.

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