Siga este link para ver outros tipos de publicações sobre o tema: Age.
Teses / dissertações sobre o tema "Age"
Crie uma referência precisa em APA, MLA, Chicago, Harvard, e outros estilos
Veja os 50 melhores trabalhos (teses / dissertações) para estudos sobre o assunto "Age".
Ao lado de cada fonte na lista de referências, há um botão "Adicionar à bibliografia". Clique e geraremos automaticamente a citação bibliográfica do trabalho escolhido no estilo de citação de que você precisa: APA, MLA, Harvard, Chicago, Vancouver, etc.
Você também pode baixar o texto completo da publicação científica em formato .pdf e ler o resumo do trabalho online se estiver presente nos metadados.
Veja as teses / dissertações das mais diversas áreas científicas e compile uma bibliografia correta.
1
Hokkanen, Suvi Rosa Kastehelmi. "Old-age hippocampal sclerosis in the aged population". Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/275889.
Texto completo da fonteResumo:
Old-age hippocampal sclerosis (HS), characterised by severe neuron loss in hippocampal CA1, is a poorly understood cause of dementia. At present no objective pathological HS criteria exist. In life HS is commonly diagnosed as Alzheimer's disease. HS aetiology is unclear, although it has been associated with both ischaemia and TAR-DNA-binding protein-43 (TDP-43)-related neurodegeneration. Variations in genes GRN, TMEM106B and ABCC9 are proposed as HS risk factors. The aim of this thesis was to investigate epidemiological, clinical, pathological and genetic characteristics of HS in older European populations. 976 brains donated for the Cambridge City over-75s Cohort, the Cognitive Function and Ageing Study and the Finnish Vantaa 85+ study were available for evaluation -including bilateral hippocampi from 302 individuals. A protocol capturing the extent and severity of hippocampal neuron loss was developed, establishing objective HS diagnosis criteria and allowing observation of distinct neuron loss patterns associated with ischaemia and neurodegeneration. 71 HS cases (overall prevalence: 7.3%) were identified. HS was significantly associated with an advanced age at death as well as dementia at the end of life. Neuropsychological and cardiovascular characteristics were similar between HS and AD, except for a longer duration of dementia and more disability in HS. HS was not associated with neurofibrillary tangles, amyloid plaques, or vascular pathologies, but all HS cases evaluated for TDP-43 showed neuronal inclusions in the hippocampal dentate and a high frequency of other glial, neuronal and neurite TDP-43 pathologies. GRN and TMEM106B but not ABCC9 variations were linked to HS. A moderating effect of TDP-43 on this association was detected. HS presented pathologically similarly to frontotemporal dementia cases with TDP-43 (FTLD-TDP) caused by mutations in GRN, but differed from other FTLD-TDP subtypes. Results of this thesis reveal the importance of HS in the oldest old in the population, the key role of TDP-43, as well as providing robust methods to capture HS characteristics for an area that has been under-researched but is clearly vital to understanding dementia in the oldest old.
2
Hladišová, Lenka. "Age management". Master's thesis, Česká zemědělská univerzita v Praze, 2016. http://www.nusl.cz/ntk/nusl-257442.
Texto completo da fonteResumo:
The concept of age management as a management with regard to the age of employees is due to demographic changes increasingly important topic. Therefore it is necessary the organizations should take care about age management to get by competitive fight and to avoid loosing experienced, qualified and loyal employees. Age management is gaining prominence due to delay founding families, an aging population and the lack of labor force. The basic threatened groups of age management are mainly workers 50+, graduates and ultimately mothers with small children. All these groups of workers require attention and the management of each organization should take care about them.
The aim of this work is to identify the pillars of the field of age management as part of human resources management in an organization, including evaluation of their objectives, strategies used within a given area. From a qualitative survey, namely structured interviews with human resources employees and after that with all managers can say that the organization is aware of the risks associated with the employment of graduates and workers 50+ and part of human resources management is to focus on risky groups of employees. The organization is aware of the qualities of its employees and is trying to use their retention of knowledge that human capital brings to achieve competitive advantage.
3
Jirásková, Barbora. "Age management". Master's thesis, Česká zemědělská univerzita v Praze, 2016. http://www.nusl.cz/ntk/nusl-261472.
Texto completo da fonteResumo:
This thesis processes the concept of the human resources management with respect to the age structure of employees in the intentions of the Czech Republic. In the theoretical part, there is outlined the history of the application of the principle of age management, focusing on current demographic trends, forecasts of population age structure, the aging workforce and the need to preserve the ability to work into old age. Points to the need to adapt corporate strategy, personnel management trend of an aging population. It presents ideas for the main underlying programs and legislative measures which form the basis of the latest concepts and strategic plans in the Czech Republic and Europe. The empirical part deals with a specific level of allowance organization established by TSU and two sub investigation. The first is a case study of age management staff. The resulting data are confronted with the results of a survey among employees of the organization. The second investigation are interviews with members of management and employees of the HR department on the issue of the introduction of age management, their awareness of the concept of age management, the question of age discrimination, the issue of maintaining the continuity of knowledge in the organization and their views on these topics. The outcome of this survey indicates a willingness and readiness of the organization has already received age management principles adhere to and develop further.
4
Homola, Ondřej. "Acid Drop Age". Master's thesis, Vysoké učení technické v Brně. Fakulta výtvarných umění, 2015. http://www.nusl.cz/ntk/nusl-232447.
Texto completo da fonte
5
Hruby, Steffan. "New Age Atheist". The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1555380659655266.
Texto completo da fonte
6
Stewart, Seth. "Age of legends". Thesis, University of Oregon, 2011. http://hdl.handle.net/1794/12190.
Texto completo da fonteResumo:
1 score (viii, 129 p. ： music)Age of Legends is an original orchestral composition in three movements, of approximately twenty minutes in duration. In the tradition of the literature-inspired symphonic poem, the piece is based on the celebrated fiction series The Wheel of Time , by acclaimed American author Robert Jordan (1948-2007). The title of the thesis refers to a particularly enchanting era described in the series, wherein the magical and miraculous are interwoven into everyday life. The piece's three movements portray a purely musical depiction of the breathtaking adventures that unfold throughout the fourteen-volume fantasy saga, evoking its richly imaginative scenes and thrilling, dramatic developments. Additionally, the music seeks to embody the intense emotional and psychological states experienced in the lives of The Wheel of Time 's fascinating literary characters, as they undergo defining moments of tremendous bravery, extreme peril, and exultant triumph.
Committee in charge: Dr. Robert Kyr, Chair; Dr. David Crumb, Member; Dr. Jack Boss, Member
7
Franco, Sâmia de Brito. "A língua age". reponame:Repositório Institucional da UFSC, 2015. https://repositorio.ufsc.br/xmlui/handle/123456789/160754.
Texto completo da fonteResumo:
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Sócio Econômico, Programa de Pós-Graduação em Relações Internacionais, Florianópolis, 2015Made available in DSpace on 2016-04-19T04:17:09Z (GMT). No. of bitstreams: 1 337706.pdf: 1754039 bytes, checksum: 10854df560520034e3f9ea8659c78d7e (MD5) Previous issue date: 2015
A presente dissertação aborda a política externa para a difusão da língua portuguesa empreendida pelo governo Lula (2003-2010). A pergunta norteadora deste trabalho foi: Por que houve uma expansão de iniciativas de difusão da língua portuguesa no governo Lula (2003-2010). A hipótese construída a partir da provocação inicial é a de que o governo Lula buscou impulsionar a expansão dos instrumentos de difusão da língua portuguesa para alcançar suas aspirações políticas e econômicas na política exterior, ou seja, fortalecer coalizões para participar mais assertivamente nos organismos multilaterais e proporcionar um ambiente mais favorável para as empresas nacionais. Foram usadas fontes primárias, como por exemplo, documentos do Arquivo Documental do Itamaraty em Brasília, e documentos disponíveis nos portais e publicações oficiais do governo brasileiro. Também nos servimos de fontes secundárias, como livros, trabalhos acadêmicos (teses e dissertações), revistas eletrônicas especializadas, anais de congresso, entre outros. Conceitos provindos da Economia Política do Sistemas-Mundo (EPSM), e o de Soft Power foram utilizados no intuito de compreender o contexto da política exterior brasileira para difusão linguística e a implementação da política de difusão linguística no período do governo Lula. Diante dos conceitos teóricos e dos dados coletados, percebeu-se que o governo Lula direcionou sua política externa de difusão linguística, principalmente, para as regiões da América Latina e África, no afã de alcançar suas aspirações políticas e econômicas não só na escala regional, como na escala global. Os resultados deste trabalho apontam que o governo Lula buscou, a partir de oportunidades conjunturais, imprimir uma maior dinamização e complementaridade de elementos culturais para o alcance de seus objetivos externos. Desse modo, esta dissertação contribui para os estudos da política externa brasileira e difusão de elementos culturais e, assim, problematiza e incentiva outros pesquisadores a aprofundar estudos desenvolvidos na área.
Abstract : This dissertation discusses the foreign policy and the Portuguese language diffusion conducted by Lula's governement (2003-2010). The question which guided this research was: why were the initiatives of language diffusion expanded during Lula's government? The hypothesis developed from the initial question is that Lula's government impulsed the expansion of the Portuguese language diffusion instruments in order to achieve its political and economics goals in foreign policy, in other words, build up coalitions to play an assertive role in multilateral organisms and provide a favorable enviroment to national enterprises abroad. The data were collected from primary resources, in Itamaraty's Documental Archive, and also in an oficial site and publications of the Brazilian Government, as well as in secondary resourses including, books, academic works (thesis and dissertations), specialized digital magazines, conference annals and others. Concepts from the World Systems Theory as well as the concept of Soft Power were mixed to understand the context of the linguistic diffusion in the Brazilian foreign policy and its implementation during Lula's government. Based on the theoric concepts and the collected data, it was shown that Lula's government conducted its linguistic foreign policy towards the Latin American and African regions as a result of Brazilian political and economic goals not only in those regions but also globally and structurally. The results of this research pointed that Lula's government, regarding conjuctural opportunities, has tried to boost and add the use of cultural elements to achieve its external objectives. In that way, this dissertation contributes to studies of Brazilian foreign policy and cultural elements difussion by problematizing and encouraging other researchers to deepen the studies in the area.
8
Hancock, Holly Elizabeth. "Age and functional asymmetry : do lateralized functions decline differentially with age?" Thesis, Georgia Institute of Technology, 1997. http://hdl.handle.net/1853/28661.
Texto completo da fonte
9
Reeves, Michael Dennis. "Age-typing across occupations when, where, and why age-typing exists". Master's thesis, University of Central Florida, 2011. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/4825.
Texto completo da fonteResumo:
The present study sought to determine the direction and degree to which occupations representative of all major occupational categories are viewed as age-typed (i.e., more appropriate for older or younger workers). The 60 occupations examined were the 12 most common and familiar occupations in each of five occupational categories used by the U.S. Census Bureau. I randomly assigned 365 participants to one of three survey conditions. Participants rated the feature centrality, proportional representation, normative age, and optimal performance age of 20 of the 60 occupations and the age-type of 20 different occupations. Results showed that participants reliably rated the occupations on a continuum from highly young-typed to highly old-typed. Occupations viewed as most appropriate for older workers included psychologists (clinical), bus drivers, and librarians, whereas those viewed as most appropriate for younger workers included recreation and fitness workers, bartenders, and hosts/hostesses. Interestingly, despite commonly held stereotypes that older workers are less competent than younger workers (Kite, Stockdale, Whitley, & Johnson, 2005), old-typed occupations were viewed as requiring higher competence than those viewed as young-typed. Additionally, roughly three times as many workers are needed to fill the most young-typed jobs compared to the most old-typed jobs (U.S. Census Bureau, 2000). Both of these findings suggest problems for an increasingly aging workforce (Administration of Aging, 2010). I also found that perceived proportional representation accounted for 79% of the variance in predicting the age-type of occupations. This suggests that people rely on general impressions of current worker ages, which supports career timetables theory's approach to the formation of occupational age-type. Implications for theory and research are discussed.ID: 030646252; System requirements: World Wide Web browser and PDF reader.; Mode of access: World Wide Web.; Thesis (M.S.)--University of Central Florida, 2011.; Includes bibliographical references (p. 86-100).
M.S.
Masters
Psychology
Sciences
Industrial Organizational Psychology
10
Oakley-McKeen, Kathryn J. (Kathryn Jill) Carleton University Dissertation Psychology. "Semantic congruity and age comparisons; towards a theory of psychological age". Ottawa, 1992.
Encontre o texto completo da fonte
11
Weiss, Elizabeth Marie. "Age Discrimination in personnel decisions : a reexamination and extension". Thesis, Georgia Institute of Technology, 2001. http://hdl.handle.net/1853/31017.
Texto completo da fonte
12
Earles, Julie Lynn. "The effects of environmental context on memory : an examination of age differences". Thesis, Georgia Institute of Technology, 1992. http://hdl.handle.net/1853/28634.
Texto completo da fonte
13
Seo, Young J. "Outcomes of students with learning disabilities at age 21 and age 24 /". Thesis, Connect to this title online; UW restricted, 2005. http://hdl.handle.net/1773/7635.
Texto completo da fonte
14
Sanchez, Paul. "Coming of Age: A Look at Minimum Age Requirements in Professional Sports". Honors in the Major Thesis, University of Central Florida, 2005. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/802.
Texto completo da fonteResumo:
This item is only available in print in the UCF Libraries. If this is your Honors Thesis, you can help us make it available online for use by researchers around the world by following the instructions on the distribution consent form at http://library.ucfBachelors
Health and Public Affairs
Legal Studies
15
Whiting, Catherine Rebecca. "Age at work : the discursive construction of age and the older worker". Thesis, Birkbeck (University of London), 2012. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.681233.
Texto completo da fonteResumo:
This research uses discourse analysis to explore constructions of age and the older worker in job search websites. These were identified on a Government website, Age Positive, a central location of age policy. The seemingly objective and factual nature of age and the older worker is ideal for sceptical examination of taken-for-granted knowledge. The de-stabilization of chronology, with age an aspect of equality, makes these relevant topics for investigation. The discourse analytic methodology is located ontologically and epistemologically within theories of social constructionism and discourse, and examines age and the older worker not as essentialist research categories but as díscursively constructed phenomena. ln the context of job search, age (positioned as older age) is constructed as risk and organiser of work; as negative ontology; as difference; as enterprise; and as commodíty. Older workers are constructed as Dinosaurs, Wise Owls and Wrinklies; as having special needs; as different; a safe pair of hands and a good match for marginal and flexible work. The older worker as victim and 'has been' is back-grounded. A minority are 'successful'. Discursive struggle is examined as job search websites seek to accommodate a business rationale that promotes older workers and a legal requirement not to discriminate against younger candidates. The constructions do little to challenge prevailing age norms and organizational structures that marginalise and constrain employment opportunities for older workers. Responding to the under-theorisation of age in organizations (Riach, 2011; Trethewey, 2001), this thesis posits that organizations are 'aged' through discourse, similar to being 'gendered' (Acker, 1990) and 'raced' (Ashcraft & Allen, 2003). This allows examination of the 'aged' claims to nature of organizations, making visible the hidden structures that are not age-neutral but described and conceived in terms of a discourse of older age as decline and of hegemonically defined differences between young and old.
16
Tubb, Paul Christopher. "The Bronze Age-Iron Age transition in the Vale of Pewsey, Wiltshire". Thesis, University of Bristol, 2009. http://hdl.handle.net/1983/34f0ca62-9bcc-4d0c-9eb7-3ac8854c2ef7.
Texto completo da fonteResumo:
This research set out to investigate the nature and extent of prehistoric human activity in the Vale of Pewsey, Wiltshire, a relatively poorly understood area located between the Marlborough Downs and Salisbury Plain. This was to be achieved through a combination of archival reassessment, aerial photographic interpretation and non-intrusive fieldwork. It became obvious that the Vale was the location for a considerable density of Late Bronze Age/Early Iron Age sites, many of which were so called "midden" or "black-earth "sites, and this dissertation concentrates on this period. A survey of some 240 square km of the Vale was undertaken and the results analysed in the context of the few blackearth sites in the area that had previously been investigated. A number of well preserved sites dating from this period were identified and surveyed for the first time and fragments of the late prehistoric landscape defined and discussed.
17
Keyes, Laura Marie. "Age Friendly Cities: The Bureaucratic Responsiveness Effects on Age Friendly Policy Adoption". Thesis, University of North Texas, 2017. https://digital.library.unt.edu/ark:/67531/metadc984140/.
Texto completo da fonteResumo:
Challenging a long-held attachment to the medical model, this research develops a cultural model placing local governments at the center of policy making and refocusing policy attention on mobility, housing, the built environment and services. To examine the phenomenon of age friendly policy adoption by cities and the magnitude of adoption, a 21-question web-based survey was administered to a sample of 1,050 cities from the U.S. Census having a population over 10,000 and having at least 14% of their population aged 65 years and over. The goal of the questionnaire was to help identify what kind of policy objectives cities establish to facilitate the opportunity for older adults to live healthy and independent lives in their communities as they age. Multiple linear and ordinal regression models examined the likelihood of policy action by cities and provide evidence as to why some cities support more age friendly policy actions than others. Evidence illustrates theoretical advancement providing support for a cultural model of aging. The cultural model includes multiple factors including bureaucratic responsiveness reflected in the management values of the administration. Findings show variation in the integration of a cultural awareness of aging in the municipality's needs assessment, strategic goals, citizen engagement strategies, and budgetary principles. Cities with a cultural awareness of aging are more likely to adopt age friendly policies. Findings also provide support for the argument that the public administrator is not the driving sole factor in decision making. A shared spaced with mobilized citizen need of individuals 65 and over is identified.
18
Saffer, Dylan. "Does Age Matter? Comparing CEO Age and Social Media Success in Startups". Scholarship @ Claremont, 2017. http://scholarship.claremont.edu/cmc_theses/1685.
Texto completo da fonteResumo:
In this paper, I examine the role of CEO age in predicting the success of startup firms, as measured by social media exposure. I use a novel measure of early-stage growth defined by increased levels of social media and online traction. I hypothesize that the age of the company’s CEO will be negatively correlated with their social media scores while controlling for the company’s total funding amounts and employee counts. My data consists of 250 United States-based startup companies that were founded between 2011 and 2015. Furthermore, they are all relatively successful in that they are still operating and have received between $100 thousand and $10 million of funding. I find that the social media score of a company is negatively impacted by the age of their CEO.
19
Buckberry, Jo, e M. Brickley. "Estimation of juvenile age at death". CIFA, 2018. http://hdl.handle.net/10454/17519.
Texto completo da fonte
20
Pevar, Sara Lynn. "The Last Ice Age". The University of Montana, 2010. http://etd.lib.umt.edu/theses/available/etd-06182010-114322/.
Texto completo da fonte
21
Wilson, Candice C. "Training retirement age volunteers". Menomonie, WI : University of Wisconsin--Stout, 2006. http://www.uwstout.edu/lib/thesis/2006/2006wilsonc.pdf.
Texto completo da fonte
22
Khan, Muhammad Aurangzeb. "Automatic facial age estimation". Thesis, Lancaster University, 2015. http://eprints.lancs.ac.uk/76420/.
Texto completo da fonteResumo:
The reliability of automatically estimating human ages, by processing input facial images, has generally been found to be poor. On other hand, various real world applications, often relating to safety and security, depend on an accurate estimate of a person’s age. In such situations, Face Image based Automatic Age Estimation (FI-AAE) systems which are more reliable and may ideally surpass human ability, are of importance as and represent a critical pre-requisite technology. Unfortunately, in terms of estimation accuracy and thus performance, contemporary FI-AAE systems are impeded by challenges which exist in both of the two major FI-AAE processing phases i.e. i) Age based feature extraction and representation and ii) Age group classification. Challenges in the former phase arise because facial shape and texture change independently and the magnitude of these changes vary during the different stages of a person’s life. Additionally, contemporary schemes struggle to exploit age group specific characteristics of these features, which in turn has a detrimental effect on overall system performance. Furthermore misclassification errors which occur in the second processing phase and are caused by the smooth inter-class variations often observed between adjacent age groups, pose another major challenge and are responsible for low overall FI-AAE performance. In this thesis a novel Multi-Level Age Estimation (ML-AE) framework is proposed that addresses the aforementioned challenges and improves upon state-of-the-art FI-AAE system performance. The proposed ML-AE is a hierarchical classification scheme that maximizes and then exploits inter-class variation among different age groups at each level of the hierarchy. Furthermore, the proposed scheme exploits age based discriminating information taken from two different cues (i.e. facial shape and texture) at the decision level which improves age estimation results. During the process of achieving our main objective of age estimation, this research work also contributes to two associated image processing/analysis areas: i) Face image modeling and synthesis; a process of representing face image data with a low dimensionality set of parameters. This is considered as precursor to every face image based age estimation system and has been studied in this thesis within the context of image face recognition ii) measuring face image data variability that can help in representing/ranking different face image datasets according to their classification difficulty level. Thus a variability measure is proposed that can also be used to predict the classification performance of a given face recognition system operating upon a particular input face dataset. Experimental results based on well-known face image datasets revealed the superior performance of our proposed face analysis, synthesis and face image based age classification methodologies, as compared to that obtained from conventional schemes.
23
Danielsson, Oscar. "Multimodal Brain Age Estimation". Thesis, KTH, Skolan för elektroteknik och datavetenskap (EECS), 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-281834.
Texto completo da fonteResumo:
Machine learning models trained on MRI brain scans of healthy subjects can be used to predict age. Accurate estimation of brain age is important for reliably detecting abnormal aging in the brain. One way to increase the accuracy of predicted brain age is through using multimodal data. Previous research using multimodal data has largely been non-deep learning-based; in this thesis, we examine a deep learning model that can effectively utilize several modalities. Three baseline models were trained. Two used T1-weighted and T2- weighted data, respectively. The third model was trained on both T1- and T2- weighted data using high-level fusion. We found that using multimodal data reduced the mean absolute error of predicted ages. Afourth model utilized disentanglement to create a representation robust to missing T1- or T2-weighted data. Our results showed that this model performed similarly to the baselines, meaning that it is robust to missing data and at no significant cost of prediction accuracy.Maskininlärningsmodeller tränade på MR-data av friska personer kan användas för att estimera ålder. Noggrann uppskattning hjärnans ålder är viktigt för att pålitligt upptäcka onormalt åldrande av hjärnan. Ett sätt att öka noggrannheten är genom att använda multimodal data. Tidigare forskning gjord med multimodal data har till stor del inte varit baserad på djupinlärning; i detta examensarbete undersöker vi en djupinlärningsmodell som effektivt kan utnyttja flera modaliteter. Tre basmodeller tränades. Två använde T1-viktad respektive T2-viktad data. Den tredje modellen tränades på både T1- och T2-viktad data genom högnivå-fusion. Vi fann att användning av multimodal data minskade det genomsnittliga absoluta felet för estimerade åldrar. En fjärde modell använde separering (eng. disentanglement) för att skapa en representation som är robust vid avsaknad av T1- eller T2-viktad data. Resultaten var lika för denna modell och basmodellerna, vilket innebär att modellen är robust mot avsaknad av data, utan någon betydande försämring i noggranhet.
24
Harnau, Jonas. "Age-period-cohort models". Thesis, University of Oxford, 2018. http://ora.ox.ac.uk/objects/uuid:b23d5253-739a-4660-8505-034c6114eed2.
Texto completo da fonteResumo:
While over-dispersed Poisson age-period-cohort and extended chain-ladder models are used in a number of fields, so far no rigorous statistical theory has been available. We consider models for aggregate data organized in a two-way table with age and cohort as indices, but without measures of exposure. In these models, used for example in actuarial science, demography, economics, epidemiology and sociology, the number of parameters grows with the number of observations. Thus, standard asymptotic theory is invalid. In Chapter 2, we propose a repetitive structure that keeps the dimension of the table fixed while increasing the latent exposure. We pair this with the assumptions of infinitely divisible distributions which include a variety of compound Poisson models and Poisson mixture models. We then show that Poisson quasi-likelihood estimation results in asymptotic t parameter distributions, F inference, and t forecast distributions. In Chapter 3, we build on the asymptotic framework from Chapter 2 and develop tests for model specification. The over-dispersed Poisson model assumes that the over-dispersion is common across the data. A further assumption is that effects do not have breaks, for example age effects do not vary over cohorts. A log-normal age-period-cohort model makes similar assumptions. We show that these assumptions can easily be tested and that similar tests can be used in both models. In Chapter 4, we develop a non-nested test that allows one to evaluate whether the over-dispersed Poisson or log-normal model is the better choice for the data. While the over-dispersed Poisson model imposes a fixed variance to mean ratio, the log-normal models assumes the same for the standard deviation to mean ratio. We leverage this insight to propose a test that has high power to distinguish between the two models. Again, the theory is asymptotic but does not build on a large size of the array and instead makes use of information accumulating within the cells.
25
Morrison, Nina. "The age of innocence". Thesis, University of Iowa, 2018. https://ir.uiowa.edu/etd/6223.
Texto completo da fonteResumo:
My work as a queer, feminist playwright is centered around reimagining the presentation of women and other marginalized people on stage. I write highly theatrical comedies meant to highlight and satirize aspects of presentation and representation related to gender, race and power. This play is titled The Age of Innocence, like the Edith Wharton novel which I have never read. I learned from the internet that Wharton wrote the novel in 1920 when she was 50 years old and thinking about her childhood days in New York City in the 1870’s long before the horrors of WWI. The novel is about the forbidden love and extramarital affair between very wealthy white people who cannot deny their love but are afraid of any impropriety that could threaten their wealth and social status. My play of the same title is inspired by Wharton’s novel and also by the very public breakup announcement made by famous television writer-director Jill Soloway and famous poet Eileen Myles. Soloway and Myles announced their breakup at a museum lecture that was supposed to be about queer media and queer literature. They decided to use the public speaking opportunity to publicly announce their breakup and process details of their relationship with the audience. My play is a comedy that borrows the premise of the Soloway Myles breakup announcement and a little of the structure of Wharton’s novel to examine gender presentation, race, privilege, romance and age.
26
Parkin, Tim G. "Age and the aged in Roman society : demographic, social and legal aspects". Thesis, University of Oxford, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334229.
Texto completo da fonte
27
Nilsson, Ethel. "Teosofi och New Age : Teosofiska Samfundets doktriner som inspiration till New Age-rörelsen". Thesis, Linköpings universitet, Institutionen för kultur och kommunikation, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-68718.
Texto completo da fonteResumo:
Den esoteriska teosofin har fått betydelse för det moderna sekulariserade samhället framför allt genom New Age-rörelsen under 1900-talets senare del och den gav redan under seklets första årtionden upphov till nya andliga rörelser i Europa och USA. Man har ofta glömt dess förankring i det sena 1800-talet. Teosofin, kunskapen eller visheten om Gud, har visserligen en betydligt äldre historia men den rörelse som skapades i Amerika på 1870-talet av Helena Blavatsky och hennes sympatisörer kom att överleva och kom att mer än hundra år senare vara aktuell i den moderna andliga rörelse vi kallar New Age. Det Teosofiska Samfundet, bildat i USA 1875, gav även upphov till flera vitala sidogrenar som till exempel Antroposofiska Sällskapet, Temple of the People, the Arcane School, the ” I AM” Religious Activity, the Church Universal and Triumphant och Liberala Katolska kyrkan vilka idag fortfarande bedriver aktiv verksamhet. De böcker och tidskrifter som 1800-talets esoteriska teosofer gav ut var ingen lättfattlig eller enkel litteratur och lästes företrädesvis av människor med den tidens bildning. De utgjorde en begränsad grupp och strävade inte efter att bli en folkrörelse. Varför blev då den esoteriska teosofin en rörelse som spred sig över Europa, USA och de dåvarande engelska kolonierna Indien och Australien? På vad sätt har Teosofiska Samfundet påverkat New Age? Detta är de två frågeställningar uppsatsen skall försöka belysa. Framställningen har begränsats till utvecklingen av den teosofi som spreds av Teosofiska Samfundet och jag ha avstått från att närmare belysa i vilken mån de sidogrenar som uppstod kom att påverka dagens samhälle. En sådan riktning var till exempel den antroposofiska rörelsen som tidigt bröt sig ur Teosofiska Samfundet och som vuxit sig mycket stark, och det finns också andra grenar som omtalas i texten men som inte närmare studerats. En annan begränsning är att studien av den teosofi som utgick från Helena Blavatsky omfattar tiden från 1875 och fram till omkring 1929 och jag har således inte studerat den inverkan teosoferna senare fick i Indien och dess självständighetsrörelse och inte heller berört Teosofiska Samfundets teosofiska riktning i dagens samhälle. I New Age-rörelsen har jag främst valt ut några riktningar som har nära anknytning till den esoteriska teosofin men avstått från att närmare studera andra som till exempel tarotkort, kristaller och stenar, astrologi, healing och dess olika riktningar, paganism och shamanism. New Age-rörelsens syn på världsbild och gudsbild, occultism och spiritism, reinkarnation och UFO har drag som man återfinner i den teosofiska rörelse som uppstod i slutet av 1800-talet.
28
Crow, Timothy M. "A history of Geshur in the Late Bronze Age and Iron Age periods". Thesis, University of Liverpool, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.485871.
Texto completo da fonteResumo:
The principal aim of this study is to explore the Late Bronze and Iron Age horizons of Geshur, and seek to defme the nature of Geshur as an historical entity based on limited textual and archaeological evidence. The thesis is structured around siX; chapters which provide the framework for understanding Geshur: Chapter 1 introduces the reader to Geshur, and sets forth the methodological issues of how the thesis views the use of historical sources and the archaeological record. The author proceeds on the premise that an independent use of both data sources followed by their convergences will enhance the understanding of Geshur. Chapter 2 studies the landscape of Geshur, the quality of the land and its impact on the flow ofhistoI)' in the region. The topography and environmental factors of Geshur reveal that the area to the east of the Sea of Galilee was an ideal locale for the emerging of a socially complex entity, with the necessary rain and natural resources to sustain life. Chapter 3 is an overview of the grander political landscape of the ancient Near East in the LB-Iron Age. A proper understanding of Geshur begins with placing it contextually in its geopolitical environment. The analysis, though brief, of sociopolitical structures over a broad range of spatial and temporal contexts helps to frame a perspective on any localized event. Chapter 4 in many ways was the 'point of origin' for this investigation. The only reason why this research project is called a 'HistoI)' of Geshur' is the biblical references which exist for Geshur. This chapter offers an analysis of all the direct citations of Geshur in the Bible, which are found in the Deuteronomistic HistoI)'. However, also explored are areas from the Bible where one might expect a citation of Geshur, but there is none. Even after all direct references mentioning Geshur end, there is ongoing activity recorded in the Bible in this area. Chapter 5 is an analysis of textual data which derives from non-biblical sources. Since Egypt and Assyria used Palestine as a travel corridor and their kings were known for campaigning in the southern Levant, one assumes that there may be references to either Geshur or the area around Geshur found in these sources. Chapter 6 moves the research from'the texfual data to the archaeological record. The archaeological data with which an analysis of LB-Iron Age Geshur is constructed derives from the empirical assessment of the stratigraphy and of the archaeological record of sites and surveys in its region. After this, the second half of the chapter utilizes a 'ground plan approach' to explore if there are indicators in the archaeological record that may point towards or reflect upon the social, political, and perhaps religious spheres of Geshur. All six chapters when combined reveal that Geshur was ideally situated in an environmental and political landscape by which it benefitted. By combining the textual and archaeological record it seems possible that Geshur may have started emerging in the Late Bronze Age, followed by an observable socially complex Iron Age polity, with its end possibly coming during the campaigns ofTiglath-pileser III in 733/32 B.C.
29
Manuel, Rhoda. "Effects of target age and participant age on attitude inferences and their accuracy". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0005/MQ42411.pdf.
Texto completo da fonte
30
Lima, Sarah. "Feasting in the Bronze Age and early Iron Age Aegean variability and meaning /". Cincinnati, Ohio : University of Cincinnati, 2007. http://www.ohiolink.edu/etd/view.cgi?acc%5Fnum=ucin1182187762.
Texto completo da fonteResumo:
Thesis (M.A.)--University of Cincinnati, 2007.Title from electronic thesis title page (viewed Oct. 8, 2007). Includes abstract. Keywords: Bronze Age, Iron Age, Euboea, Thebes, Pylos, Palace of Nestor, Nichoria, Lefkandi, Xeropolis, Toumba, Heröon, feasting, banqueting, dining, diacritical. Includes bibliographical references.
31
Noack, Carl Martin Gunter [Verfasser]. "Age Climate : age stereotypes in organizations and older workers / Carl Martin Gunter Noack". Bremen : IRC-Library, Information Resource Center der Jacobs University Bremen, 2009. http://d-nb.info/1034994816/34.
Texto completo da fonte
32
Alexander, Patrick. "Learning to act your age : negotiating age imaginaries in an English secondary school". Thesis, University of Oxford, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.543726.
Texto completo da fonte
33
Bouthillier, Christina. "A 'peripheral' place in a 'dark' age : the Iron Age ceramics of Cilicia". Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648291.
Texto completo da fonte
34
Walts, Nancy S. "Multidimensional assessment of cognitively impaired adults age 65 years of age and older". Virtual Press, 1988. http://liblink.bsu.edu/uhtbin/catkey/535895.
Texto completo da fonteResumo:
The purpose of the study was to validate the use of the Geriatric Functional Rating Scale (GFRS) in assessing cognitively impaired individuals 65 years of age and older to determine the need for institutionalization. The population of interest consisted of individuals 65 years of age and older exhibiting cognitive impairment and residing in Delaware County, Indiana. A nonrandomized two-group experimental design was utilized for the study. Eighty subjects were selected from two subpopulations consisting of 40 institutionalized and 40 noninstitutionalized elderly.Two geriatric assessment tools were used for the study, the Mental Status Questionnaire (MSQ) and the Geriatric Functional Rating Scale (GFRS). The hypothesis for the study stated that the mean GFRS score of the noninstitutionalized subjects, the control group, would be significantly greater than the mean score of the institutionalized subjects, the experimental group.The MSQ scores as well as the means and standard deviations for the seven subscales of the GFRS were reported for the two groups. A one-tailed t-test was used to test the hypothesis. A decision with regard to the hypothesis was made at the .05 level.Findings of the study included the following:1. The subjects ranged in age from 65 to 92 years, were 90 percent female, and predominantly Protestant, 88 percent.2. The MSQ scores for the combined groups ranged from minimal cognitive impairment, 71 percent, to severe cognitive impairment, four percent.3. The total mean score on the GFRS for the institutionalized group was 6.8 indicating a need for institutionalization.4. The total score on the GFRS of the noninstitutionalized was over 10 times higher at 70.7.5. The noninstitutionalized group scored significantly higher in the GFRS (p<.00) than the institutionalized counterparts.In conclusion, the research supports the use of the Geriatric Functional Rating Scale in assessing the need for institutionalization in cognitively impaired individuals, 65 years of age and older in Delaware County, Indiana.Department of Educational Administration and Supervision
35
Abu-Samaha, Ala'M. "The age of the smart medium : development and evaluation in the electronic age". Thesis, University of Salford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366013.
Texto completo da fonte
36
Parker, Catherine Ruth. "Arkadia in transition : exploring late Bronze Age and early Iron Age human landscape". Thesis, University of Birmingham, 2008. http://etheses.bham.ac.uk//id/eprint/235/.
Texto completo da fonteResumo:
This research explores the region of Arkadia in the Late Bronze Age and Early Iron Age using an interpretative and phenomenologically inspired approach. It is region associated with many myths pointing to a continuing population throughout the period, yet beset with a problematic archaeological record. This has been the result of a number of factors ranging from the nature of the landscape to the history of research. However, the ability to locate sites of the Late Bronze Age and Early Iron Age within the landscape, allows insight into a region we had little hope of enlightening using more conventional approaches to the archaeological record. This theoretical and methodological stance is illustrated through an exploration of different aspects of the human experience such as religion, death and burial and the everyday. The ways in which these aspects can and usually are interpreted are considered, followed by a number of case studies, which are employed to explore how human actions were embedded within and informed by the very physicality of the landscape, and the differences apparent throughout time.
37
Martin, Susanne. "Dancing age(ing) : rethinking age(ing) in and through improvisation practice and performance". Thesis, Middlesex University, 2016. http://eprints.mdx.ac.uk/18984/.
Texto completo da fonteResumo:
Set in the context of contemporary dance this thesis investigates how improvisation practice and performance making participate in a critical rethinking of age(ing). Advancing the notion of an age critical dance practice, the research draws on the theoretical frameworks of age studies – a multidisciplinary field of critical inquiry informed by, largely speaking, feminist and poststructuralist theories. The age critical dance practice developed in this thesis, in turn, enters into conversation with the discourses established in age studies and dance studies as a way to incorporate age critique into dance. The thesis is a Practice as Research project consisting of a written thesis, two solo performances (The Fountain of Youth, premiered 2013, and The Fountain of Age, premiered 2015), and employs immersive dance based research methods such as the development of a Solo Partnering practice (as documented on DVD). The research also remodels the method of qualitative interviewing into a performative method that allows the participating expert practitioners to tap into their unique improvisation and performance expertise when addressing their particular understanding of age(ing). Through the development and analysis of improvised practice and performance making, alongside in-depth performative interviews, the findings of this research point to ways in which improvisation and performance embody age critical potential. The long-term, open-ended and agentic artistic processes that improvisation experts develop all share a range of characteristics that serve to challenge the established youth-orientation in dance and constitute an implicitly critical position to dominant understandings of age(ing) in dance. Consequently, the thesis argues that improvisation practices ‘do’ age(ing) in ways less prone to dualistic stereotyping and reiterations of (self‐) discriminatory age(ing)-as‐decline narratives that dominate our culture as a whole. The research also suggests strategies in performance making that enable representations of age(ing) in ways that collide with, resist, or complicate normative expectations on age(ing). The dance works presented in this thesis allow the dancer to articulate shifting perspectives and experiences, creating ambiguous meanings and disjunctive narratives of age(ing), and thereby making explicit a critical position towards the grand narratives of age(ing). In conclusion, this research argues that specific approaches to a long-term, open-ended dance practice, alongside critical images and new imaginations of age(ing) in performance, allow dance to evolve as an age critical arts practice.
38
Tanksley, Peter T. "From age to aging: Biological age and its role in the criminal career". University of Cincinnati / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1601995918198417.
Texto completo da fonte
39
LIMA, SARAH WHITNEY. "FEASTING IN THE BRONZE AGE AND EARLY IRON AGE AEGEAN: VARIABILITY AND MEANING". University of Cincinnati / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1182187762.
Texto completo da fonte
40
Barnes, Kristi A. "Examining predictors of marital satisfaction among age similar and age discrepant older couples". Morgantown, W. Va. : [West Virginia University Libraries], 2003. http://etd.wvu.edu/templates/showETD.cfm?recnum=3297.
Texto completo da fonteResumo:
Thesis (Ph. D.)--West Virginia University, 2003.Title from document title page. Document formatted into pages; contains v, 116 p. : ill. Includes abstract. Includes bibliographical references (p. 87-94).
41
Åkesson, Emil. "Age of the Cremated : On the estimation of age of burnt human remains". Thesis, Stockholms universitet, Osteoarkeologiska forskningslaboratoriet, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-182048.
Texto completo da fonteResumo:
The estimation of age is an important aspect in osteoarchaeological analysis. In order to understand people and their fates in past societies, researchers must turn to palaeodemography. Therefore, it is vital that the methods of age estimation, which the foundations of palaeodemographic reconstructions rest upon, are as accurate and reliable as possible. In current Swedish cremation-osteoarchaeology, two methods of age estimation are commonly used: suture closure and relative thickness of the diploë. However, no substantial evaluation of these two methods have been undertaken. This study aims to evaluate the two methods of age estimation of cremated remains, suture closure and relative thickness of the diploë. This was done by testing the two methods on two unburnt populations, Mediaeval city-dwellers from Helgeandsholmen, Stockholm, Sweden, and Middle-Neolithic hunter-gatherers from Ajvide, Gotland, Sweden. Suture closure and proportion of diploë was observed in comparison with age-related changes of the auricular surface of the ilium and the pubic symphysis. Based on the results of the study, possible courses of action were proposed and then applied on cremated remains from a Late Iron Age burial ground on Lovö, Stockholm, Sweden. The results showed significant moderate correlation with age for both methods (0.61 for suture closure and 0.58 for proportion of diploë). However, early stage of suture closure could identify a group consisting of juveniles and young adults, while advanced suture closure could identify a group consisting of middle adults and old adults. These results, which proved to be more reliable than existing methods, can, hopefully, lead to improvements of the assessment of age in cremated remains, and increase our understanding of the fates of people of the past.
42
MacVey, Nicolle. "Ontogenetic diet shifts and prey selection among age-0 and age-1 paddlefish". OpenSIUC, 2013. https://opensiuc.lib.siu.edu/theses/1126.
Texto completo da fonteResumo:
Many fishes are planktivorous during early life and switch to piscivory or consume larger food items as ontogeny progresses. In contrast, paddlefish begin life as active feeders selecting for larger organisms and then switch to planktivory as they grow. Few studies have quantified these changes in early life foraging. I identified distinct early life foraging behaviors and prey preferences of age-0 paddlefish and how these change with habitat and paddlefish size. Gut contents of 189 age-0 wild paddlefish were used to determine which prey are most preferred and whether habitat variables and paddlefish size influence diet composition. I also performed an experiment to identify differences in foraging behavior and prey preference between age-0 and age-1 paddlefish. Dominant prey, based on percent by number and percent occurrence, of wild age-0 paddlefish ranging from 10 to 116 mm TL was trichoptera larvae (28.5%N, 67.7%O) and hemiptera (18.3%N, 51.3%O). Prey size increased with size of age-0 paddlefish. However, the highest ratio of zooplankton to invertebrates in the gut occurred in a 60 mm paddlefish. The size range of fish in this study was likely too narrow to confirm presence of an ontogenetic diet shift. Habitat had no effect on diet. My experimental study revealed that if provided a mixture of organisms, age-0 paddlefish will primarily consume macroinvertebrates while age-1 paddlefish will mainly filter zooplankton, but occasionally consume larger organisms. Features of river channels (e.g., woody snags, gravel beds in the photic zone) that contribute to the diverse diet paddlefish require in early life may ultimately increase survival and recruitment.
43
Sheppard, Laura Janine. "Negative behavior exhibited by preschool children in same-age versus mixed-age groups". PDXScholar, 1985. https://pdxscholar.library.pdx.edu/open_access_etds/3528.
Texto completo da fonteResumo:
Perhaps due to the increase in the workforce of mothers with young children, much attention has been directed in the past decade towards the subject of out-of-home child care.
In order to gain further understanding of the socialization of preschool children, an observational study was carried out which was designed to measure the amount of negative behavior expressed by children participating in mixed-age versus same-age preschool groups.
44
Carlzon, Eric. "Spår av sjukliga förändringar i gotländskt, mänskligt benmaterial, från stenålder till medeltid – en sammanställning av forskningsläget på Gotland". Thesis, Uppsala universitet, Institutionen för arkeologi och antik historia, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-363263.
Texto completo da fonteResumo:
This bachelor thesis is a compilation of previous master and bachelor theses written by osteology students at Högskolan på Gotland and Uppsala University Campus Gotland, with a focus on palaeopathology in individuals from the island of Gotland, from the Stone Age through the Middle Ages. The purpose of this thesis is to shed light on the history of disease on the island of Gotland on a bigger scale than previous theses have done. Most master and bachelor theses have typically focused on one site or settlement, set in a particular time period in their study, whereas I chose to combine all of the studies into one cohesive examination of all disease surveyable in the skeleton of these individuals. This, in order to see if there are differences to be found in the various time periods, or even differences among the population within a specific time period. And there are some differences to be seen, indeed; most notably perhaps between the Iron Age and the Middle Ages, where a difference in the dental health can clearly be seen. When comparing the other time periods however, caution must be advised; the skeletal material is lacking in most eras other than the Iron Age and the Middle Ages.
45
Glatt, Katharina. "Star clusters as age tracers of the age-metallicity relation of small magellanic cloud /". [S.l.] : [s.n.], 2009. http://edoc.unibas.ch/diss/DissB_8741.
Texto completo da fonte
46
Keil, Mathias, e Birgit Spanner-Ulmer. "Chemnitz Age Model – an interdisciplinary research basic approach to characterize age critical performance factors". Universitätsbibliothek Chemnitz, 2009. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-200902050.
Texto completo da fonteResumo:
The central basis for an age appropriate design of products and processes lies primarily in the adaptation of the altering performance factors of aging people. Results about the changing performance of people are available for several research areas. The “Chemnitz Age Model” as an interdisciplinary approach has got the explicit aim to collect present research data, to review this data with regard to its usability and its eventual transfer to a comprehensive age model. Furthermore, the results will be represented in the “Chemnitz Age Database” in a systematic way. The profound basis of knowledge allows an age appropriate development and adaptation of products and processesDie zentrale Basis für eine altersgerechte Gestaltung von Produkten und Prozessen liegt primär in der Anpassung an die sich im Alter ändernden Leistungsfaktoren des Menschen. Ergebnisse über die Veränderung der Leistungsfähigkeit des Menschen liegen bereits in verschiedenen Forschungsgebieten vor. Das „Chemnitzer Altersmodell“ hat als interdisziplinärer Forschungsansatz das Ziel, vorhandene Forschungsergebnisse zusammenzutragen, hinsichtlich ihrer Verwertbarkeit zu überprüfen und in ein ganzheitliches, arbeitswissenschaftliches Altersmodell zu überführen. Die Ergebnisse werden in der „Chemnitzer Altersdatenbank“ strukturiert erfasst. Die fundierte Wissensbasis ermöglicht eine alternsgerechte Entwicklung und Anpassung von Produkten und Prozessen
47
Bergqvist, Anders. "From the sugar age to the information age. : A new high school in Kävlinge". Thesis, KTH, Arkitektur, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-146819.
Texto completo da fonteResumo:
Decommissioned buildings and structures from the industrial age constitutes a challenge for many municipalities when society and the global economy changes. The transformation of the old sugar mill in Kävlinge originates from that shift – from the production of goods to an information and knowledge based society. How can this type of building be re-programmed as a stimulating place for sharing and acquire knowledge, and at the same time perform well in terms of energy? The sustainable strategies for energy preservation includes a new transparent second skin - a glass corridor facade, which stores the heat from the thermal mass (bricks). It also includes a passive ventilation system, using underground ducts to heat or cool the building depending on season.Avvecklade byggnader och strukturer från industrialismen utgör en utmaning för många kommuner när samhället och den globala ekonomin förändras. Omvandlingen av det gamla sockerbruket i Kävlinge tar sin utgångspunkt från det skiftet - från produktionen av varor till ett informations-och kunskapssamhället. Hur kan denna typ av byggnad omprogrammeras till en stimulerande plats för att dela och tillägna sig kunskap, och samtidigt prestera bra vad det gäller energi? De hållbara strategierna för energieffektivitet innefattar ett nytt transparent klimatskal som lagrar värmen från den termiska massan (tegel). Den innehåller också ett passivt ventilationssystem, som med hjälp av underjordiska schakt värmer eller kyler byggnaden beroende på säsong.
48
van, Otterdijk Sanne Dorien. "The role of age-related DNA methylation in the development of age-related disease". Thesis, University of Newcastle upon Tyne, 2013. http://hdl.handle.net/10443/2337.
Texto completo da fonteResumo:
Alterations in DNA methylation can have dramatic effects on gene transcription, and in particular, hypermethylation of promoter associated CpG islands is known to lead to gene inactivation. Altered patterns of DNA methylation play a key role in the development of cancer and may also play important roles in many other diseases. However, the mechanisms which lead to these changes in DNA methylation are unknown. DNA methylation patterns have also been found to change during normal ageing and these changes have similarities to those that occur during the development of cancer. This suggests that for some age-related diseases, most notably cancer, altered patterns of methylation may be an early initiating event and that disease may develop in cells which already possess changes in their DNA methylation landscape. Therefore, this study was designed to examine how methylation levels at a group of genes alters over the life-course and how these relate to methylation changes observed in major age-related diseases (cancer, specifically acute lymphoblastic leukaemia (ALL) and Hereditary Nonpolyposis Colorectal Cancer (HNPCC) patients, and atherosclerosis). DNA was collected from healthy volunteers from different ages and from ALL, HNPCC and atherosclerosis patients. Methylation was quantified using pyrosequencing. The study produced a number of findings: 1) Genes exhibiting variable methylation in PBL samples from healthy volunteers are also highly methylated in leukaemia, suggesting a common underlying mechanism. 2) Increased methylation levels were observed in lymphoid compared to myeloid cells, in healthy individuals, mirroring the patterns seen in leukaemia. 3) A subset of genes exhibiting variable methylation in PBL samples from healthy volunteers and that are highly methylated in leukaemia are aberrantly methylated in HNPCC patients and atherosclerosis patients, suggesting shared risk factors. 4) While methylation levels increase during ageing, a substantial proportion of methylation is already present at birth and may thus alter disease susceptibility throughout life. 5) Blood samples from ALL patients in remission exhibit increased methylation levels (versus controls), not directly related to their leukaemic clone, and the extent of methylation correlates with overall survival. The studies to date are compatible with a hypothesis in which altered methylation of disease-related genes pre-exists in a subset of haematopoietic cells and that these cells may be at a significantly increased risk of progression to age-related diseases. Furthermore, monitoring DNA methylation may be a valuable tool for early diagnosis of these diseases, as well as for monitoring disease progression in patients.
49
Greenhalgh, Charlotte Maree. "An age of emotion : expertise and subjectivity in old age in Britain, 1937-1970". Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:18c215e1-a9fe-43ac-9879-9a8da8678836.
Texto completo da fonteResumo:
This thesis heeds W. Andrew Achenbaum’s call for historians of ageing to analyse the inner lives of their subjects. Building on and problematizing existing studies of health and welfare policies for the old, it explores the ways that mid-century public and private life shaped how individuals felt about old age. Both public discussions and private narratives of ageing are used to consider how older people understood and expressed their emotional experiences during a challenging period of the life cycle. I argue that old age in general, and its emotional dimensions in particular, are missing from British historiography. Yet both were vital to social life in the mid-century, when the ageing population was an important political issue and a large number of experts hoped to manage the emotional and psychological aspects of this ‘problem’. This thesis begins by setting out this national context for old age, showing that heightened interest in ageing and emotion were significant influences over the expansion of the welfare state. However, contrary to the expectations of mid-century researchers and policy-makers, my subsequent chapters show that older people frequently maintained their social roles and relationships through informal means. This thesis explores how ageing men and women engaged with work, retirement, ill health, marriage, bereavement, fashion, beauty culture, and autobiography as opportunities to find meaning in late life. Together, these varied perspectives on old age make a series of interventions in its history. I argue that historians could do much more to detail the significance of the life cycle for their subjects, whether they write political, social, or cultural history. As this thesis shows, such studies should approach ageing as a lifelong and personal process, which has been shaped by reminiscence and story-telling. I suggest that historians of emotion are best-equipped to write scholarship that is sensitive to the passing of time and personal biography in this way.
50
Costa, Sofia de Oliveira Serra. "Targeting Higher in Age Preparing the Retail Business for the New Age Senior Segment". Master's thesis, Faculdade de Economia da Universidade do Porto, 2008. http://hdl.handle.net/10216/49889.
Texto completo da fonte