Literatura científica selecionada sobre o tema "Affinity-Based protein profiling"
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Artigos de revistas sobre o assunto "Affinity-Based protein profiling"
Wirsing, Lisette, Kai Naumann e Thomas Vogt. "Arabidopsis methyltransferase fingerprints by affinity-based protein profiling". Analytical Biochemistry 408, n.º 2 (janeiro de 2011): 220–25. http://dx.doi.org/10.1016/j.ab.2010.09.029.
Texto completo da fonteLafreniere, Matthew A., Geneviève F. Desrochers, Kedous Mekbib e John Paul Pezacki. "An affinity-based probe for methyltransferase enzymes based on sinefungin". Canadian Journal of Chemistry 95, n.º 10 (outubro de 2017): 1059–63. http://dx.doi.org/10.1139/cjc-2017-0168.
Texto completo da fonteBuneeva, Olga, Arthur Kopylov, Oksana Gnedenko, Marina Medvedeva, Alexander Veselovsky, Alexis Ivanov, Victor Zgoda e Alexei Medvedev. "Proteomic Profiling of Mouse Brain Pyruvate Kinase Binding Proteins: A Hint for Moonlighting Functions of PKM1?" International Journal of Molecular Sciences 24, n.º 8 (21 de abril de 2023): 7634. http://dx.doi.org/10.3390/ijms24087634.
Texto completo da fonteJung, Se-Hui, Kangseung Lee, Deok-Hoon Kong, Woo Jin Kim, Young-Myeong Kim e Kwon-Soo Ha. "Integrative Proteomic Profiling of Protein Activity and Interactions Using Protein Arrays". Molecular & Cellular Proteomics 11, n.º 11 (26 de julho de 2012): 1167–76. http://dx.doi.org/10.1074/mcp.m112.016964.
Texto completo da fonteMa, Nan, Zhi-Min Zhang, Jun-Seok Lee, Ke Cheng, Ligen Lin, Dong-Mei Zhang, Piliang Hao, Ke Ding, Wen-Cai Ye e Zhengqiu Li. "Affinity-Based Protein Profiling Reveals Cellular Targets of Photoreactive Anticancer Inhibitors". ACS Chemical Biology 14, n.º 12 (19 de novembro de 2019): 2546–52. http://dx.doi.org/10.1021/acschembio.9b00784.
Texto completo da fonteChen, Xiong, Menglin Li, Manru Li, Dongmei Wang e Jinlan Zhang. "Harnessing affinity-based protein profiling to reveal a novel target of nintedanib". Chemical Communications 57, n.º 25 (2021): 3139–42. http://dx.doi.org/10.1039/d1cc00354b.
Texto completo da fonteChou, Po-Hung, Shu-Hua Chen, Hsin-Kai Liao, Po-Chiao Lin, Gour-Rong Her, Alan Chuan-Ying Lai, Jenn-Han Chen, Chun-Cheng Lin e Yu-Ju Chen. "Nanoprobe-Based Affinity Mass Spectrometry for Selected Protein Profiling in Human Plasma". Analytical Chemistry 77, n.º 18 (setembro de 2005): 5990–97. http://dx.doi.org/10.1021/ac050655o.
Texto completo da fonteLyu, Peng, Shengrong Li, Ying Han, Shengnan Shen, Zheling Feng, Piliang Hao, Zhengqiu Li e Ligen Lin. "Affinity-based protein profiling-driven discovery of myricanol as a Nampt activator". Bioorganic Chemistry 133 (abril de 2023): 106435. http://dx.doi.org/10.1016/j.bioorg.2023.106435.
Texto completo da fonteCheng, Xiamin, Lin Li, Mahesh Uttamchandani e Shao Q. Yao. "A tuned affinity-based staurosporine probe for in situ profiling of protein kinases". Chemical Communications 50, n.º 22 (2014): 2851. http://dx.doi.org/10.1039/c4cc00184b.
Texto completo da fonteMezentsev, Yuri, Pavel Ershov, Evgeniy Yablokov, Leonid Kaluzhskiy, Konstantin Kupriyanov, Oksana Gnedenko e Alexis Ivanov. "Protein Interactome Profiling of Stable Molecular Complexes in Biomaterial Lysate". International Journal of Molecular Sciences 23, n.º 24 (10 de dezembro de 2022): 15697. http://dx.doi.org/10.3390/ijms232415697.
Texto completo da fonteTeses / dissertações sobre o assunto "Affinity-Based protein profiling"
Mahajan, Shikha. "Protein Profiling of Adenine Nucleoside and Nucleotide Analogs Binding Proteins Using N6-Biotinylated-8-azidoadenosine Analogs as Affinity Based Protein Profiling Probes". Scholar Commons, 2012. http://scholarcommons.usf.edu/etd/4139.
Texto completo da fonteYedji, Rodrigue. "Perturbateurs endocriniens de type phtalate et poisson zèbre Danio rerio : approche chémoprotéomique pour l'identification des cibles et recherche de signatures d'exposition". Electronic Thesis or Diss., Université de Lorraine, 2022. http://www.theses.fr/2022LORR0106.
Texto completo da fontePhthalate esters are a family of synthetic compounds widely used as plasticisers. They are used in a number of plastic products such as packaging, toys, cosmetics, plastic roofing system and furniture decoration materials. Phthalates are not covalently bonded to the polymer matrix and are therefore easily released into the environment, resulting in animal and human exposure. In the absence of non-toxic substitutes, phthalate compounds are still widely used in industry, despite the classification of some of them by the European Chemicals Agency (ECHA) as suspected toxic substances and as endocrine disruptors. In addition, they are carcinogenic and teratogenic. The deleterious effect of phthalate esters on organisms is established, but the multiple nature of the effects observed shows that the mechanisms of action of phthalates are only partially elucidated. We used two targeted proteomics approaches to shed light on the mechanisms of action of phthalate esters. Dibutyl phthalate (DBP) was used as a model phthalate and zebrafish (D. rerio) as a model organism. Using the first targeted proteomics approach, affinity-based protein profiling (AfBPP), the functional disruption of proteins by DBP with photoaffinity probes from aryl azide synthesis was demonstrated. Optimisation of the binding conditions for diazirine probes (Diazirine 2) should provide us with a probe that can be used to identify DBP protein targets in the zebrafish proteome. The second approach, activity-based protein profiling (ABPP), used a reactive probe specific for serine hydrolases (SHs) to map active SHs in the zebrafish proteome for the first time. The identification of deregulated SHs in the presence of DBP in zebrafish larvae was also reported in this study. Overall, our results indicate that targeted proteomics approaches such as ABPP or AfBPP can be an asset for understanding xenobiotic-related mechanisms of action in ecotoxicology
Qundos, Ulrika. "Antibody based plasma protein profiling". Doctoral thesis, KTH, Proteomik och nanobioteknologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-126270.
Texto completo da fonteQC 20130821
Neiman, Maja. "Bead based protein profiling in blood". Doctoral thesis, KTH, Proteomik, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-117960.
Texto completo da fonteQC 20130208
Drobin, Kimi. "Antibody-based bead arrays for high-throughput protein profiling in human plasma and serum". Licentiate thesis, KTH, Proteinvetenskap, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-225980.
Texto completo da fonteQC 20180412
Rosa, Mira Anne dela Cruz dela, e 羅米拉. "Targeted Quantification and Glycosylation Profiling of Protein Biomarkers by Nanoprobe-based Affinity Mass Spectrometry". Thesis, 2016. http://ndltd.ncl.edu.tw/handle/84414137238466490842.
Texto completo da fonte國立臺灣大學
化學研究所
104
Disease biomarker development is plagued by lack of acceptable analytical methods, difficulty and cost for method development, overwhelming need for validation on a large population and the poor performance of biomarkers under development. In this dissertation, we introduce alternative methods for protein biomarker discovery and validation that encompasses quantification and post-translational modification (PTM) profiling in non-invasive specimens. We first designed surfactant-coated monodisperse magnetic nanoprobes to improve detection sensitivity (MNP@IGEPAL). Following oriented antibody immobilization for increased specificity and immuno-activity, the MNP@IGEPAL were found to be superior in solvent dispersibility and enrichment efficiency compared to nanoprobes obtained by conventional co-precipitation method (MNPCP). We then coupled the MNP@IGEPAL-based enrichment to multiple reaction monitoring mass spectrometry (MRM-MS) for multiplexed quantification of alpha-fetoprotein (AFP) and golgi membrane protein 1 (GOLM1), which are low-abundant biomarkers in human serum. The method was found to be sensitive, have good analytical merits (average precision and accuracy of 15%) and wide dynamic range. This method was applied to qualify the biomarkers in serum of liver disease patients, where we found that AFP and GOLM1 had similar diagnostic accuracy for hepatocellular carcinoma (HCC), although AFP has a higher false negative rate (sensitivity = 22%). More importantly, we found complementarity between AFP and GOLM1, where GOLM1 was found to be elevated in 69% of patients with low AFP concentration (<20 ng/mL). To supplement disease diagnoses based on protein concentration, we designed a one-pot dual nanoprobe-based mass spectrometry method to simultaneously quantify the protein and profile its post-translational modification (PTM). Using AFP and another clinically-relevant protein, haptoglobin (Hp), we were able to quantify the protein and profile its glycoforms with superior speed and sensitivity and minimal amount of sample. In addition to obtaining individual biosignatures of AFP in HCC patients, we were able to identify a total of 59 glycoforms, 12 of which were identified on AFP for the first time. Ultimately, we were able to develop methods that can improve disease diagnosis, which can be applied to other cancers and diseases for large-scale biomarker triaging, qualification and PTM profiling.
Capítulos de livros sobre o assunto "Affinity-Based protein profiling"
Birgersson, Elin, Jochen M. Schwenk e Burcu Ayoglu. "Bead-Based and Multiplexed Immunoassays for Protein Profiling via Sequential Affinity Capture". In Methods in Molecular Biology, 45–54. New York, NY: Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-7057-5_4.
Texto completo da fonteTrabalhos de conferências sobre o assunto "Affinity-Based protein profiling"
Warder, Scott E., Shaun M. McLoughlin, T. Matthew Hansen, Paul L. Richardson, Denise M. Wilcox, Sadiya N. Addo, Hua Tang et al. "Abstract 3059: Discovery of BET family proteins as cancer targets using phenotypic-based profiling and affinity capture mass spectrometry". In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-3059.
Texto completo da fonte