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1

Kang, Ji-Eun, Hye-Jung Lee, Sabina Lim, et al. "Acupuncture Modulates Expressions of Nitric Oxide Synthase and c-Fos in Hippocampus After Transient Global Ischemia in Gerbils." American Journal of Chinese Medicine 31, no. 04 (2003): 581–90. http://dx.doi.org/10.1142/s0192415x03001235.

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The effects of acupuncture on the expressions of nitric oxide synthase (NOS) and c-Fos in the hippocampus of gerbils after transient ischemia were investigated via nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) histochemistry and Fos immunohistochemistry. In animals of the ischemia-induction groups, both common carotid arteries were occluded for 5 minutes. Animals of the acupunctued groups were given acupunctural treatment at Zusanli twice daily for 9 consecutive days. Acupuncture was shown to decrease NADPH-d and c-Fos levels in both the sham-operation group and the ischemia
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2

Zhang, Jiarun, Weizhen Wu, Li Wan, et al. "Comparative Study of Najia and Nazi Acupunctures to Reduce Rat Gastric Ulcer." Acupuncture & Electro-Therapeutics Research 44, no. 3 (2020): 191–201. http://dx.doi.org/10.3727/036012920x15779969212937.

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Gastric ulcer is a common digestive system disease, which leads to the serious decline in the life quality and effective therapies are in urgent need. Midnightmidday ebb flow acupunctures including Najia and Nazi acupunctures have been applied in clinics in China for more than one thousand years and the acupoints are selected according to the time rhythm. Najia acupuncture, namely day-prescription of acupoints, divides ten days (one cycle) into 120 two-hour periods and each period is coordinated with a meridian. Meanwhile, Nazi acupuncture, namely hour-prescription of acupoints, divides a day(
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3

Cai, Wuying. "Acupuncture and the Nervous System." American Journal of Chinese Medicine 20, no. 03n04 (1992): 331–37. http://dx.doi.org/10.1142/s0192415x92000369.

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Acupuncture is based on neuroanatomy and neurophysiology. At each acupuncture point, there are peripheral nerves and terminals. Acupuncture will be useful for further understanding of the nervous system. A conceptual view of acupuncture's physiology is presented.
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Yang, Chae Ha, Bong Hyo Lee, and Sung Hoon Sohn. "A Possible Mechanism Underlying the Effectiveness of Acupuncture in the Treatment of Drug Addiction." Evidence-Based Complementary and Alternative Medicine 5, no. 3 (2008): 257–66. http://dx.doi.org/10.1093/ecam/nem081.

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Clinical trials are currently underway to determine the effectiveness of acupuncture in the treatment of drug addiction. While there are still many unanswered questions about the basic mechanisms of acupuncture, some evidence exists to suggest that acupuncture can play an important role in reducing reinforcing effects of abused drugs. The purpose of this article is to critically review these data. The neurochemical and behavioral evidence showed that acupuncture's role in suppressing the reinforcing effects of abused drugs takes place by modulating mesolimbic dopamine neurons. Also, several br
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5

Jang, Mi-Hyeon, Min-Chul Shin, Baek-Vin Lim, et al. "Acupuncture Increases Nitric Oxide Synthase Expression in Hippocampus of Streptozotocin-induced Diabetic Rats." American Journal of Chinese Medicine 31, no. 02 (2003): 305–13. http://dx.doi.org/10.1142/s0192415x03000989.

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In the present study, the effect of acupuncture at Zusanli acupoint on nitric oxide synthase (NOS) expression in the hippocampus of streptozotocin (STZ)-induced diabetic rats was investigated via nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) histochemistry. Animals were divided into four groups: the control group, the nondiabetic and acupunctured group, the STZ-induced diabetes group, and the STZ-induced diabetes and acupunctured group. From the results, NADPH-d-positive neurons in the hippocampus were decreased in STZ-induced diabetic rats, while acupuncture increased NOS e
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Hullender Rubin, Lee E., Belinda J. Anderson, and LaTasha B. Craig. "Acupuncture and in vitro fertilisation research: Current and future directions." Acupuncture in Medicine 36, no. 2 (2018): 117–22. http://dx.doi.org/10.1136/acupmed-2016-011352.

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Background Acupuncture is a common adjuvant treatment to support patients undergoing in vitro fertilisation (IVF). However, the impact of acupuncture and the different roles it can play in IVF remain unclear. Objective In this paper, we present an overview and critique of the current evidence on acupuncture's impact on IVF-related stress, describe harms, and propose future directions for investigation. Conclusion Two to three acupuncture sessions performed on or around the day of embryo transfer are insufficient interventions to improve IVF birth outcomes but provide significant IVF-related st
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7

Langevin, Helene M., David L. Churchill, James R. Fox, Gary J. Badger, Brian S. Garra, and Martin H. Krag. "Biomechanical response to acupuncture needling in humans." Journal of Applied Physiology 91, no. 6 (2001): 2471–78. http://dx.doi.org/10.1152/jappl.2001.91.6.2471.

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During acupuncture treatments, acupuncture needles are manipulated to elicit the characteristic “de qi” reaction widely viewed as essential to acupuncture's therapeutic effect. De qi has a biomechanical component, “needle grasp,” which we have quantified by measuring the force necessary to pull an acupuncture needle out of the skin (pullout force) in 60 human subjects. We hypothesized that pullout force is greater with both bidirectional needle rotation (BI) and unidirectional rotation (UNI) than no rotation (NO). Acupuncture needles were inserted, manipulated, and pulled out by using a comput
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8

Li, Boxuan, Shizhe Deng, Bomo Sang, et al. "Revealing the Neuroimaging Mechanism of Acupuncture for Poststroke Aphasia: A Systematic Review." Neural Plasticity 2022 (April 21, 2022): 1–23. http://dx.doi.org/10.1155/2022/5635596.

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Background. Aphasia is a common symptom in stroke patients, presenting with the impairment of spontaneous speech, repetition, naming, auditory comprehension, reading, and writing function. Multiple rehabilitation methods have been suggested for the recovery of poststroke aphasia, including medication treatment, behavioral therapy, and stimulation approach. Acupuncture has been proven to have a beneficial effect on improving speech functions in repetition, oral speech, reading, comprehension, and writing ability. Neuroimaging technology provides a visualized way to explore cerebral neural activ
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9

Farmer, Cecilia. "Bringing Holistic Treatments to the Attention of Medicine." Journal of Evidence-Based Complementary & Alternative Medicine 20, no. 2 (2014): 120–25. http://dx.doi.org/10.1177/2156587214565459.

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This article reviews 3 studies that explore the effects of acupuncture on poststroke patients suffering from chronic stroke symptoms. The 3 studies selected strive to show how acupuncture can be a safe, noninvasive, and cost-effect rehabilitation tool useful in adjunct with traditional rehabilitation. Chou et al (2009), Hopwood et al (2008), and Wayne et al (2005) all studied acupuncture’s effects on quality of life. Additionally, both Hopwood et al and Wayne et al studied acupuncture’s effects on mobility and activities of daily living. While the frequency, duration, and length of the entire
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10

Li, Yao. "A Corpus Study of Acupuncture from the Perspective of Mass Media Based on the Corpus of Contemporary American English." Journal of Contemporary Educational Research 8, no. 7 (2024): 216–20. http://dx.doi.org/10.26689/jcer.v8i7.7418.

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Based on the Corpus of Contemporary American English (COCA), this study examines acupuncture from the perspective of mass media. Acupuncture has been circulating throughout the Chinese Cultural Circle since the Qin and Han Dynasties, and has since spread directly or indirectly to the rest of the world. The United States boasts the world’s second-largest acupuncture market, with its laws, regulations, industry growth, research, and education all positively influencing the development of acupuncture in other nations. This study uses COCA to analyze the form and content of acupuncture’s dissemina
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Nurbani, Rina, and Dwi Rachma Helianthi. "Wrist Ankle Acupuncture (WAA) and Body Acupuncture Accelerates Neurorehabilitation in Bell's Palsy: A Case Report." Journal of Agromedicine and Medical Sciences 7, no. 3 (2021): 136. http://dx.doi.org/10.19184/ams.v7i3.24818.

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Bell’s Palsy (BP) is an acute unilateral facial paralysis due to idiopathic inflammation of the peripheral facial nerve. Corticosteroids, antiviral drugs, and physical therapy could be useful to treat BP, however these treatments could not bring complete recovery. Acupuncture could be an alternative option for BP and to show its effectiveness, we present a case report, a patient with BP treated with acupuncture. A 48-year-old female patient, a kindergarden teacher, already treated with corticosteroid and antiviral agents as soon as BP was diagnosed. Six weeks later, patient didn’t recover, wit
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12

Cai, Wa, and Wei-Dong Shen. "Anti-Apoptotic Mechanisms of Acupuncture in Neurological Diseases: A Review." American Journal of Chinese Medicine 46, no. 03 (2018): 515–35. http://dx.doi.org/10.1142/s0192415x1850026x.

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Apoptosis, known as programmed cell death, plays a significant role in the pathogenesis of neurological diseases. Most of these diseases can be obviously alleviated by means of acupuncture treatment. Current research studies have shown that the efficacy of acupuncture to these medical conditions is closely associated with the anti-apoptotic potentials. Mainly based on the acupuncture’s anti-apoptotic efficacy in prevalent neurological disorders, including cerebral ischemia-reperfusion injury, Alzheimer’s disease, depression or stress related-modes, spinal cord injuries, etc., this review comes
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13

Wang, Lin, and Li-min Wang. "Perspective on acupuncture treatment for diabetic peripheral neuropathy: A perspective." Medicine 104, no. 23 (2025): e42646. https://doi.org/10.1097/md.0000000000042646.

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Acupuncture is increasingly recognized for its potential in managing diabetic peripheral neuropathy (DPN). This condition severely impacts quality of life by inducing symptoms such as pain and sensory loss, and, in severe cases, leading to amputation. Research indicates that acupuncture may alleviate these symptoms through mechanisms that include enhancing neural blood flow, promoting nerve regeneration, and modulating glucose metabolism. Despite these promising findings, the variability in acupuncture’s effectiveness, along with the methodological limitations of existing studies-such as small
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14

Guo, Xinmeng, and Jiang Wang. "Low-Dimensional Dynamics of Brain Activity Associated with Manual Acupuncture in Healthy Subjects." Sensors 21, no. 22 (2021): 7432. http://dx.doi.org/10.3390/s21227432.

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Acupuncture is one of the oldest traditional medical treatments in Asian countries. However, the scientific explanation regarding the therapeutic effect of acupuncture is still unknown. The much-discussed hypothesis it that acupuncture’s effects are mediated via autonomic neural networks; nevertheless, dynamic brain activity involved in the acupuncture response has still not been elicited. In this work, we hypothesized that there exists a lower-dimensional subspace of dynamic brain activity across subjects, underpinning the brain’s response to manual acupuncture stimulation. To this end, we em
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15

Bivins, Roberta. "The Needle and the Lancet: Acupuncture in Britain, 1683–2000." Acupuncture in Medicine 19, no. 1 (2001): 2–14. http://dx.doi.org/10.1136/aim.19.1.2.

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Although commonly regarded as a late twentieth century phenomenon, acupuncture use in Britain has a surprisingly long history, beginning with its seventeenth century transmission from China and Japan. Acupuncture was in use in the great hospitals of Paris before a second stage of transmission and translation brought it to nineteenth century Britain. Acupuncture's first wave of popularity and its results in British medical practice can be examined through examples drawn from the Lancet, the BMJ and other medical periodicals. This historical transmission of acupuncture to the UK can be fruitfull
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16

Zatta, Laidilce Teles, Leonora Rezende Pacheco, Marcus Antônio de Souza, Juliano Ricardo Santana dos Santos, Karina Machado Siqueira, and Virginia Visconde Brasil. "Acupuncture in rheumatoid arthrit’s patients: advantages, disadvantages and reasons to use this therapy." Revista de Enfermagem UFPE on line 3, no. 4 (2009): 1027. http://dx.doi.org/10.5205/reuol.581-3802-1-rv.0304200930.

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Objectives: to verify the main reasons that justify the acupuncture treatment’s search among Rheumatoid Arthrit’s patients; to identify advantages and disadvantages of this therapy. Methods: this is about a case study, performed in Hospital de Medicina Alternativa and a Private Clinic that use acupuncture as therapy, both in Goiânia. That were cases 18+, rheumatoid arthrit’s patients, acupuncture at least a month, self-evaluation and talking capables. This study was approved by the Committee of Ethics in Research of the Clinics Hospital of the Federal University of Goiás (028/2005). Results: f
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17

McTiernan, Sean. "The physiological mechanisms of acupuncture analgesia and its applications within veterinary practice." Veterinary Nurse 13, no. 6 (2022): 272–77. http://dx.doi.org/10.12968/vetn.2022.13.6.272.

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The practice of acupuncture as a method of pain relief is becoming increasingly popular in veterinary medicine. With recent advances in neuroimaging and molecular biology studies we now have measurable results to aid with our understanding of the molecular mechanisms of acupuncture-induced analgesia. Multiple body regions can be accessed through individual acupuncture points via the peripheral nervous system and its connection to the central nervous system. Acupuncture's analgesic effects can be conceptually divided into local, segmental (spinal), and suprasegmental (brain) effects and involve
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18

Laures-Gore, Jacqueline, and Rebecca Shisler Marshall. "Acupuncture as a Treatment Technique for Aphasia and Cognitive Impairments." Perspectives on Neurophysiology and Neurogenic Speech and Language Disorders 18, no. 3 (2008): 107–13. http://dx.doi.org/10.1044/nnsld18.3.107.

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Abstract Purpose: In response to the growing interest and use of acupuncture by Americans who are searching for effective treatments of aphasia and cognitive impairments, this paper serves to (a) briefly explain the technique of acupuncture, (b) describe its biologic mechanisms, and (c) summarize studies investigating the effectiveness of acupuncture in treating cognitive impairment associated with vascular dementia and stroke-related language impairments. Methods: Published reports of the use and effectiveness of acupuncture in treating cognitive impairments related to vascular dementia and a
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19

Ots, Thomas, Asal Kandirian, Istvan Szilagyi, Susan M. DiGiacomo, and Andreas Sandner-Kiesling. "The selection of dermatomes for sham (placebo) acupuncture points is relevant for the outcome of acupuncture studies: a systematic review of sham (placebo)-controlled randomized acupuncture trials." Acupuncture in Medicine 38, no. 4 (2020): 211–26. http://dx.doi.org/10.1177/0964528419889636.

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Background: Many randomized controlled trials (RCTs) of acupuncture reveal no significant differences between acupuncture and so-called placebo acupuncture. There is a strong tendency to replace the term “placebo” by the term “sham,” because any needling stimulates a certain physiological response. However, neither concept accounts for the great diversity of results in RCTs comparing verum acupuncture and sham (placebo) acupuncture. Some trials have shown little or no difference, while other studies have found statistically significant differences. Objective: Verum acupuncture and sham (placeb
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20

Ng, Hui-Ping, Chin-Ming Huang, Wen-Chao Ho, and Yu-Chen Lee. "Acupuncture Differentially Affects the High-Frequency Spectral Energy in Radial Pulse Positions Depending on Type of Lower Back Pain." Evidence-Based Complementary and Alternative Medicine 2019 (November 21, 2019): 1–16. http://dx.doi.org/10.1155/2019/4024501.

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Acupuncture is a core discipline in traditional Chinese medicine (TCM) and has been practised in China for centuries. In traditional acupuncture, pulse palpation is an important clinical diagnostic technique that guides practitioners in their treatment strategies as they evaluate the effectiveness of the treatment. This paper provides the findings of our investigation of acupuncture’s effect on specific radial pulse spectral energies in 41 individuals with lower back pain (LBP), in response to a single acupuncture treatment delivered bilaterally at acupoints BL23, BL25, and BL40. Baseline asse
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21

McDonald, John L., Allan W. Cripps, Peter K. Smith, Caroline A. Smith, Charlie C. Xue, and Brenda Golianu. "The Anti-Inflammatory Effects of Acupuncture and Their Relevance to Allergic Rhinitis: A Narrative Review and Proposed Model." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–12. http://dx.doi.org/10.1155/2013/591796.

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Classical literature indicates that acupuncture has been used for millennia to treat numerous inflammatory conditions, including allergic rhinitis. Recent research has examined some of the mechanisms underpinning acupuncture's anti-inflammatory effects which include mediation by sympathetic and parasympathetic pathways. The hypothalamus-pituitary-adrenal (HPA) axis has been reported to mediate the antioedema effects of acupuncture, but not antihyperalgesic actions during inflammation. Other reported anti-inflammatory effects of acupuncture include an antihistamine action and downregulation of
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Islam, Dr S. M. Shahidul, Dr Boxu Lang, and Sabina Yasmin. "A Case Report on Ischemic Stroke and Acupuncture." Scholars Journal of Applied Medical Sciences 10, no. 10 (2022): 1676–79. http://dx.doi.org/10.36347/sjams.2022.v10i10.014.

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Acupuncture's impact on stroke recurrence was little understood. Ischemic stroke patients who received acupuncture therapy were studied to see whether their risk of stroke recurrence was reduced. Recurrence rates per 1000 person-years fell from 71.4 without acupuncture to 69.9 with acupuncture (P= 0.01). It was shown that patients who received acupuncture therapy were less likely to have another stroke (HR 0.88; 95% CI 0.84-0.91). Acupuncture had a positive effect on stroke patients regardless of whether or not they received medical therapy for stroke prevention. The hazard ratios of stroke re
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23

Niruthisard, Supranee, Qiufu Ma, and Vitaly Napadow. "Recent advances in acupuncture for pain relief." PAIN Reports 9, no. 5 (2024): e1188. http://dx.doi.org/10.1097/pr9.0000000000001188.

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Abstract Introduction: Acupuncture therapy has achieved global expansion and shown promise for health promotion and treatment of acute/chronic pain. Objectives: To present an update on the existing evidence base for research and clinical practice supporting acupuncture analgesia. Methods: This Clinical Update elaborates on the 2023 International Association for the Study of Pain Global Year for Integrative Pain Care “Factsheet Acupuncture for Pain Relief” and reviews best evidence and practice. Results: Acupuncture is supported by a large research evidence base and growing utilization. Mechani
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24

Holyoak, Gilbert Reed, and Aituan Ma. "Evidence-Based Application of Acupuncture in Theriogenology." Veterinary Sciences 9, no. 2 (2022): 53. http://dx.doi.org/10.3390/vetsci9020053.

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Historical evidence of acupuncture predates written history. It has been a component of Traditional Chinese veterinary medicine for many generations and is officially recognized in recorded history for treating equine disease in the Zhou Dynasty, circa 1050 BC. Drawing from a range of searchable databases, we present the use of veterinary acupuncture related to theriogenology. We touch on human-based medicine only as an introduction to current uses within veterinary medical acupuncture. This review is confined to the use of acupuncture encompassing dry needle, electroacupuncture, aquapuncture,
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Li, Junjun, Liang Dong, Xuhong Yan, et al. "Is Acupuncture Another Good Choice for Physicians in the Treatment of Chronic Prostatitis/Chronic Pelvic Pain Syndrome? Review of the Latest Literature." Pain Research and Management 2020 (March 10, 2020): 1–13. http://dx.doi.org/10.1155/2020/5921038.

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This study aimed to evaluate the efficacy and safety of acupuncture for chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). A search of PUBMED, EMBASE, Central Register of Controlled Trials (CENTRAL), Web of Science, Chinese Biomedicine Literature (CBM), China National Knowledge Infrastructure (CNKI), Wang-Fang Database, Chinese Scientific Journal Database (VIP), and other available resources was made for studies (up to February 2019). Searches were limited to studies published in English and Chinese. Only randomized controlled trials (RCTs) related to the efficacy and/or safety of acu
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Pan, Weidong, Mingzhe Wang, Mao Li, et al. "Actigraph Evaluation of Acupuncture for Treating Restless Legs Syndrome." Evidence-Based Complementary and Alternative Medicine 2015 (2015): 1–7. http://dx.doi.org/10.1155/2015/343201.

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We evaluated the effects of acupuncture in patients with restless legs syndrome (RLS) by actigraph recordings. Among the 38 patients with RLS enrolled, 31 (M=12,F=19; mean age,47.2±9.7years old) completed the study. Patients were treated with either standard acupuncturen=15or randomized acupuncturen=16in a single-blind manner for 6 weeks. Changes in nocturnal activity (NA) and early sleep activity (ESA) between week 0 (baseline), week 2, week 4, and week 6 were assessed using leg actigraph recordings, the International Restless Legs Syndrome Rating Scale (IRLSRS), and Epworth Sleepiness Scale
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Georgakopoulou, Paraskevi, Evangelia Anastasiadi, and Eleftherios Paraskevopoulos. "Acupuncture Reduces Pain in Patients with Temporomandibular Joint Disorders. A Systematic Review." International Journal of Kinesiology and Sports Science 12, no. 2 (2024): 46–58. http://dx.doi.org/10.7575/aiac.ijkss.v.12n.2p.46.

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Aims: Acupuncture is an alternative method used to treat patients with Temporomandibular joint disorders (TMD). However, it still has not been well established, as an effective and safe option, in literature. This systematic review aims to investigate: (a) the quality of the methodology used in previous Randomized Controlled and Clinical Trials, concerning the effectiveness of acupuncture, in reducing pain, in patients with TMD, (b) the effectiveness of acupuncture, in reducing pain, in patients with TMD. Method: Electronic databases were investigated to identify available Randomized Controlle
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Chen, Jason Aaron, Justin Albert Chen, Sanghoon Lee, and Gerard Mullin. "Potential Role for Acupuncture in the Treatment of Food Addiction and Obesity." Acupuncture in Medicine 36, no. 1 (2018): 52–55. http://dx.doi.org/10.1136/acupmed-2017-011366.

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Addressing the global obesity epidemic requires innovative approaches that are also acceptable to affected individuals. There is growing evidence suggesting that food addiction, one contributor to obesity, bears many similarities to drug and alcohol addiction, presenting a potential role for addiction-focused acupuncture as a novel treatment modality. In this perspective article, we begin by briefly reviewing the evidence linking food and drug/alcohol addiction. We then describe the development of an acupuncture-based protocol for treating opioid addiction in Hong Kong in the 1970s and discuss
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Cheng, Meihua, and Xinyue Chen. "Image Construction of Traditional Chinese Acupuncture from the Framing Theory Perspective—A Case Study of Reports in The New York Times." Journal of Asian Research 9, no. 1 (2025): p52. https://doi.org/10.22158/jar.v9n1p52.

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As an intangible cultural heritage of humanity, traditional Chinese acupuncture has gained increasing global influence in recent years. Prominent U.S. media outlets like The New York Times have played a pivotal role in its international dissemination, shaping both its media image and public perception. Adopting framing theory as the analytical lens, this study systematically examines the image construction strategies employed by U.S. mainstream media in portraying Chinese acupuncture across three dimensions: high-level themes, mid-level narratives, and low-level expressions. Specifically, it i
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Liu, Hsu-Jan, Sheng-Feng Hsu, Chang-Chi Hsieh, et al. "The Effectiveness of Tsu-San-Li (St-36) and Tai-Chung (Li-3) Acupoints for Treatment of Acute Liver Damage in Rats." American Journal of Chinese Medicine 29, no. 02 (2001): 221–26. http://dx.doi.org/10.1142/s0192415x01000253.

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This study investigated the effects of acupuncture on carbon tetrachloride (CCl4) induced acute liver injury in male rats (n = 36). The experimental groups were injected with CCl4 before, during, or after acupuncture therapy. Acupoints similar to the human Tsu-San-Li (St-36) and Tai-Chung (Li-3) were needled bilaterally. Rats treated with CCl4 had higher levels of serum glutamate-oxalate-transaminase (sGOT) and serum glutamate-pyruvate-transaminase (sGPT). Comparing the experimental groups, biochemical and pathological parameters of liver injury were significantly reduced when rats were acupun
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Cabioglu, Mehmet Tugrul, and Gülnaz Arslan. "Neurophysiologic Basis of Back-Shu and Huatuo-Jiaji Points." American Journal of Chinese Medicine 36, no. 03 (2008): 473–79. http://dx.doi.org/10.1142/s0192415x08005916.

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Acupuncture, a method of traditional Chinese medicine that uses Back-Shu and Huatuo-Jiaji points, is especially effective for treating diseases of the visceral organs. Applying acupuncture on Back-Shu points affects visceral organs in many ways. For example, it dilates the bronchus, affects the heartbeat, stomach motility, urinary bladder contractions and so on. Acupuncture's effects can be explained as viscero-cutaneous, cutaneo-visceral, cutaneo-muscular, and viscero-muscular reflexes. Segmental dispersion of the sympathetic and parasympathetic systems is related to the location of Back-Shu
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Morawik, Iwona, Karolina Turżańska, and Mirosław Jabłoński. "Acupuncture: Ancient Remedy or Modern Placebo?" Wiadomości Lekarskie, no. 3 (March 29, 2025): 595–601. https://doi.org/10.36740/wlek/202550.

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Introduction:. Acupuncture as an alternative method of pain treatment was created in China 3000 years ago. It still has many supporters. For years, it has been used in many countries to relieve labor pains, postoperative pains, pains caused by osteoarthritis, toothaches, and headaches. The World Health Organization (WHO) has significantly expanded the indications for the use of acupuncture. The aim: The primary aim of this article is to critically evaluate whether acupuncture is a scientifically validated therapeutic intervention or primarily a placebo effect? Material and methods: The materia
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Grabous, Oleksii, Oksana Makar, Lukyan Andriyuk, and Oleksandr Hrabous. "ENHANCING SOLDIER RESILIENCE: ACUPUNCTURE TECHNIQUES FOR PAIN AND STRESS MANAGEMENT ON THE FRONTLINES." Anti-Aging Eastern Europe 3, no. 3 (2024): 141–45. http://dx.doi.org/10.56543/aaeeu.2024.3.3.05.

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This article examines the growing interest in acupuncture as a potential treatment on the battlefield, particularly for pain relief and aiding the recovery of soldiers. This trend is part of a broader movement toward the integration of complementary and alternative medicine (CAM) into military healthcare systems. The article highlights how acupuncture’s holistic approach, which differs significantly from traditional Western medicine, makes it particularly effective in managing pain by considering the physical, psychological, and other patient characteristics that contribute to imbalances. Mode
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Fan, Jing-qi, Wei-jing Lu, Wei-qiang Tan, et al. "Effectiveness of Acupuncture for Anxiety Among Patients With Parkinson Disease." JAMA Network Open 5, no. 9 (2022): e2232133. http://dx.doi.org/10.1001/jamanetworkopen.2022.32133.

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ImportanceOne of the ordinary manifestations of Parkinson disease (PD) is anxiety, which remains untreated. Anxiety is closely associated with the accelerated progression of PD. Efficacy of acupuncture for anxiety has been reported. However, to date, there are no data on acupuncture’s effectiveness on anxiety for patients with PD.ObjectiveTo investigate the effect of acupuncture vs sham acupuncture for treating anxiety in patients with PD.Design, Setting, and ParticipantsThis is randomized, double-blinded, clinical trial enrolled patients between June 20, 2021, and February 26, 2022. Final fol
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Jiang, Song-he, Wen-zhan Tu, En-miao Zou, et al. "Neuroprotective Effects of Different Modalities of Acupuncture on Traumatic Spinal Cord Injury in Rats." Evidence-Based Complementary and Alternative Medicine 2014 (2014): 1–9. http://dx.doi.org/10.1155/2014/431580.

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Spinal cord injury (SCI) can induce a series of histological, biochemical, and functional changes. Acupuncture is commonly used for SCI patients. Using male rats of spinal cord injury with the New York University (NYU) Impactor, we investigated the response of electroacupuncture (EA), manual acupuncture (MA), and transcutaneous acupoint electrical stimulation (TAES) at Shuigou (DU26) and Fengfu (DU16) acupoints to understand the effects and mechanisms of acupuncture in neuroprotection and neuronal function recovery after SCI. Histological study showed a restored neural morphology and an increa
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Yu, Xi-Wen, Cheng-Si Wang, Xi-Ze Sun, and Jia-Mei Wu. "Perspectives in clinical research on acupuncture treatment for central obesity: A perspective." Medicine 104, no. 21 (2025): e42634. https://doi.org/10.1097/md.0000000000042634.

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This study evaluates acupuncture as a viable treatment for central obesity, noting its significant effects on reducing body weight and improving metabolic health. Clinical trials attribute these benefits to acupuncture’s impact on hormonal regulation, neurological responses, and inflammation reduction. Despite its proven efficacy and minimal side effects, which promote high patient satisfaction and adherence, challenges remain. These include variability in research designs and a general lack of methodological rigor. Future research should focus on personalized treatments and integrating acupun
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Hsu, Sheng-Feng, Chien-Yue Chen, Ming-Da Ke, Chien-Hsun Huang, Yuan-Ting Sun, and Jaung-Geng Lin. "Variations of Brain Activities of Acupuncture to TE5 of Left Hand in Normal Subjects." American Journal of Chinese Medicine 39, no. 04 (2011): 673–86. http://dx.doi.org/10.1142/s0192415x11009111.

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This paper presents the evident effects of acupoint stimulation, using EEG (electroencephalogram) measurements. With acupuncture stimulation and the EEG measurement on the same meridian, EEG is able to accurately detect the effects of acupunctural point stimulation on brain waves. In this study, 24 subjects without heart or neural diseases were randomly separated into two groups of 12, named test and control groups. Similar procedures are performed; the subjects lay on a bed with eyes closed for ten minutes as the baseline. The test group received acupuncture at their Waiguan points (TE5) on t
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Romero, Sally A. D., Eileen Jiang, Jason Bussell, et al. "What makes one respond to acupuncture for insomnia? Perspectives of cancer survivors." Palliative and Supportive Care 18, no. 3 (2019): 301–6. http://dx.doi.org/10.1017/s1478951519000762.

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AbstractObjectiveLike any therapy, acupuncture is effective for some patients, while not helpful for others. Understanding from a patients' perspective what makes one respond or not to acupuncture can help guide further intervention development. This study aimed to identify factors that influence the perception of acupuncture's therapeutic effect among cancer survivors with insomnia.MethodWe conducted post-treatment semi-structured interviews with cancer survivors who were randomized to the acupuncture group in a clinical trial for the treatment of insomnia. Survivors were categorized into Res
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Bao, Ting, Susan Q. Li, Josh L. Dearing, et al. "Acupuncture versus Medication for Pain Management: A Cross-Sectional Study of Breast Cancer Survivors." Acupuncture in Medicine 36, no. 2 (2018): 80–87. http://dx.doi.org/10.1136/acupmed-2017-011435.

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Aim of the Study Breast cancer survivors who take aromatase inhibitors (AI) often suffer from chronic pain. Emerging evidence supports the use of acupuncture as an effective pain management strategy for this condition, but its acceptability among cancer survivors is unknown. We evaluated breast cancer survivors’ preferences for acupuncture as compared with medication use and identified factors predictive of this preference. Methods We conducted a cross-sectional study among breast cancer survivors who were currently, or had been, taking an AI. The primary outcome was degree of preference for a
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Wang, Shao-Jun, Hao-Yan Yang, and Guo-Shuang Xu. "Acupuncture Alleviates Colorectal Hypersensitivity and Correlates with the Regulatory Mechanism of TrpV1 and p-ERK." Evidence-Based Complementary and Alternative Medicine 2012 (2012): 1–10. http://dx.doi.org/10.1155/2012/483123.

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Here we used a mouse model of zymosan-induced colorectal hypersensitivity, a similar model of IBS in our previous work, to evaluate the effectiveness of the different number of times of acupuncture and elucidate its potential mechanism of EA treatment. Colorectal distension (CRD) tests show that intracolonic zymosan injection does, while saline injection does not, induce a typical colorectal hypersensitivity. EA treatment at classical acupoints Zusanli (ST36) and Shangjuxu (ST37) in both hind limbs for 15 min slightly attenuated and significantly blunted the hypersensitive responses after firs
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Kajla, Deepak, Maneesh Mohan, and Kenneth C. Ugoeze. "Acupuncture: A Potential Therapy for Neurological and Psychiatric Disorders." Journal of Pharmaceutical Technology, Research and Management 11, no. 2 (2023): 93–105. https://doi.org/10.15415/jptrm.2023.112002.

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Background: Acupuncture, a practice rooted in traditional Chinese medicine for thousands of years, is increasingly recognized as a complementary therapy for neurological and psychiatric disorders. Purpose: This review aims to explore recent advancements in acupuncture’s application for treating specific neurological and psychiatric conditions and to highlight its therapeutic potential and underlying mechanisms. Methods: The review synthesizes findings from extensive research and scientific studies, incorporating insights from modern neuroimaging techniques like functional magnetic resonance im
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Sjölund, Bengt H. "Acupuncture or acupuncture?" Pain 114, no. 3 (2005): 311–12. http://dx.doi.org/10.1016/j.pain.2004.12.026.

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Miller, David W., Eric J. Roseen, Jennifer A. M. Stone, et al. "Incorporating Acupuncture Into American Healthcare: Initiating a Discussion on Implementation Science, the Status of the Field, and Stakeholder Considerations." Global Advances in Health and Medicine 10 (January 2021): 216495612110425. http://dx.doi.org/10.1177/21649561211042574.

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Introduction The field of implementation science is the study of methods that promote the uptake of evidence-based interventions into healthcare policy and practice. While acupuncture has gained significant traction in the American healthcare landscape, its journey has been somewhat haphazard and non-linear. Methods In June 2019, a group of thirty diverse stakeholders was convened by the Society for Acupuncture Research with the support of a Patient Centered Outcomes Research Institute, Eugene Washington Engagement Award. This group of stakeholders represented a diverse mix of patients, provid
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Shan, Yi, Zhi-qun Wang, Zhi-lian Zhao, et al. "An fMRI Study of Neuronal Specificity in Acupuncture: The Multiacupoint Siguan and Its Sham Point." Evidence-Based Complementary and Alternative Medicine 2014 (2014): 1–6. http://dx.doi.org/10.1155/2014/103491.

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Clarifying the intrinsic mechanisms of acupuncture’s clinical effects has recently been gaining popularity. Here, we choose the Siguan acupoint (a combination of bilateral LI4 and Liv3) and its sham point to evaluate multiacupoint specificity. Thirty-one healthy volunteers were randomly divided into real acupoint (21 subjects) and sham acupoint (10 subjects) groups. Our study used a single block experimental design to avoid the influence of posteffects. Functional magnetic resonance imaging data were acquired during acupuncture stimulation. Results showed extensive increase in neuronal activit
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Pozzo, Lisa Dal, Secondo Scarsella, and Maria Abad Arranz. "Evaluating the Efficacy of Warm Acupuncture and Electroacupuncture in Temporomandibular Disorder: A Narrative Review." Perspectives on Integrative Medicine 4, no. 2 (2025): 87–95. https://doi.org/10.56986/pim.2025.06.003.

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Temporomandibular disorder (TMD) causes jaw pain, difficulty speaking/eating, and discomfort referred to the head, neck, and shoulders. Western treatments (anti-inflammatory drugs, opioids, muscle relaxants) may have side effects or may be unsuitable for older adults due to polypharmacy risks. Nonpharmacological options like physiotherapy and magnetic therapy are promising, but acupuncture, rooted in Traditional Chinese Medicine, has gained attention for its efficacy. Traditional Chinese medicine attributes TMD to Qi stagnation, blood stasis, and pathogenic factors (cold, wind, dampness), lead
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Li, Haixia, Qiongyao Xiang, Rujing Ren, and Gang Wang. "Acupuncture as a Complementary Therapy for Alzheimer’s Disease." Journal of Alzheimer's Disease 101, s1 (2024): S503—S520. http://dx.doi.org/10.3233/jad-231250.

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Alzheimer’s disease (AD) is a significant global medical concern due to the aging population. AD is featured by gradual cognitive impairment, impacting daily functioning and causing behavioral and personality changes, causing disruptive psychiatric symptoms. While pharmacological interventions are the primary clinical approach, their efficacy is variable and limited. Acupuncture, with its distinctive theoretical framework and treatment approach, has garnered attention as a non-pharmacological intervention for AD through extensive preclinical and clinical research. Neurobiological investigation
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Zhu, Qianyin, Tingyu Mu, Die Dong, Lingshan Chen, Jiayi Xu, and Cuizhen Shen. "Renin-angiotensin system mechanism underlying the effect of auricular acupuncture on blood pressure in hypertensive patients with phlegm-dampness constitution: Study protocol for a randomized controlled trial." PLOS ONE 19, no. 2 (2024): e0294306. http://dx.doi.org/10.1371/journal.pone.0294306.

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Background Phlegm-dampness constitution is a traditional Chinese medicine constitution typically associated with essential hypertension. Previous studies have demonstrated that auricular acupuncture effectively decreases blood pressure and adjusts the constitution. However, the mechanism underlying auricular acupuncture’s effect is poorly understood. Methods A non-blinded, randomized controlled trial will be undertaken between September 2022 and May 2023. Eighty essential hypertensive patients with a phlegm-dampness constitution will be randomly allocated to one of two groups. The intervention
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Kim, Yoon Sang. "The Impact of Acupuncture and Moxibustion on the Microenvironment." Science Insights 41, no. 2 (2022): 599–603. http://dx.doi.org/10.15354/si.22.re072.

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Acupuncture therapy is an essential part of traditional Chinese medicine that is being recognized by an increasing number of countries due to its convenience, effectiveness, and low risk of adverse reactions. The microenvironment is important in the occurrence, development, treatment, and rehabilitation of diseases, and has recently become a focus of research in the field of various diseases. Acupuncture’s therapeutic effect on the human body begins in the microenvironment (acupoints) and ends in the microenvironment (lesions). Many reports on the mechanism of acupuncture and moxibustion are w
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Calandruccio, Amy. "Acupuncture Effects on COVID -19 Long- Hauler Syndrome." Journal of Alternative, Complementary & Integrative Medicine 10, no. 1 (2024): 1–8. http://dx.doi.org/10.24966/acim-7562/100444.

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This study provides a foundation for future acupuncture research for COVID-19 long-hauler syndrome for the symptoms of dysgeusia, anosmia, and brain fog. Dissemination of information on acupuncture’s efficacy is needed.
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MacPherson, Hugh. "Evidence-Based Acupuncture? a Challenge Ahead." Asian Medicine 1, no. 1 (2005): 147–61. http://dx.doi.org/10.1163/157342105777996755.

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Acupuncture's increasingly widespread use has been paralleled by calls for more rigorous evidence of its effectiveness. In this article, some of the challenges of developing a strong evidence base are explored. As acupuncture is a complex intervention, a case is made for the appropriateness and relevance of pragmatic rather than experimental randomised controlled trials in the evaluation of acupuncture. Within this context there remain key challenges associated with ensuring treatment within a trial is sufficiently flexible, so that it can match the expected variability in patients, that outco
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