Teses / dissertações sobre o tema "Acidic patch"
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Martin, Franck. "Structural and functional studies of chromatin remodeling complex mamalian SWI / SNF". Electronic Thesis or Diss., Strasbourg, 2024. http://www.theses.fr/2024STRAJ044.
Texto completo da fonteChromatin is a dynamic structure regulated by various epigenetic mechanisms, including ATP-dependent chromatin remodeling such as SWI/SNF. Their importance is such that mutations in chromatin remodeling proteins are strongly associated with several diseases, including cancer. For example, BCL7 proteins, which are newly identified core subunits of the mammalian SWI/SNF complex, are associated with different types of cancer, such as Diffuse Large B-cell Lymphoma (DLBCL). To date, information on BCL7 proteins is very limited. Using biochemical and structural approaches, this project aims to better understand the structure and function of these auxiliary subunits. We report here that the proteins bind to the nucleosome with its N-terminal regions, which include an arginine anchoring motif, and that mutation of one of these arginines directly impacts binding to the nucleosome. We also hypothesize that the position within the SWI/SNF complex of BCL7, which interacts with the ARP module and more specifically with ACTB via a 2W motif, is directly linked to BAF47. We were also able to identify that once on the nucleosomes, BAF47 takes its place on the acidic patch and the BCL7A helix is displaced
Malieieva, Galyna. "Les acides gynkgolique et niflumique sont les nouveaux modulateurs de récepteur à la glycine". Thesis, Aix-Marseille, 2017. http://www.theses.fr/2017AIXM0030/document.
Texto completo da fonteGlycine receptor is a ligand-gated neuronal receptor that possesses an ion pore permeable for Cl- and represents an important component of inhibitory neurotransmission in CNS of vertebrates. Glycine receptors participate in the control of motor activity, respiration, inflammatory pain sensation, perception of visual and auditory stimuli. Development of efficient modulators of glycine receptors will allow a precise control of their activity, which is especially important in the case of glycine receptor pathologies, such as hyperekplexia. In the present work we have identified ginkgolic and niflumic acids as novel modulators of glycine receptors, characterized their action on different subunits of the receptor and determined the most probable sites of interaction of the compounds with glycine receptors
Peverini, Laurie. "Conception et application de nouveaux outils photochimiques pour l’étude des récepteurs canaux P2X". Thesis, Strasbourg, 2017. http://www.theses.fr/2017STRAF061/document.
Texto completo da fonteP2X receptors are cationic ligand-gated ion channels, activated by extracellular ATP, involved in many physio-pathological roles. Their function is associated with different allosteric states. During this PhD, we have designed three new strategies, spanning photochemical organic synthesis and patch-clamp electrophysiology to elucidate the molecular mechanisms involved in these conformational states and to collect data in order to study structure-function relationships. - Synthesis and application of molecular tweezers, which allows the photo-control of P2X Rand the study of molecular motions - Synthesis and characterization of a photo-cleavable amino acid with the aim of incorporating it into P2XR and doing structure-function relationships - Incorporation of an unnatural amino acid for photo-crosslinking studies. We have been able to probe the molecular mechanism involved in large organic cations permeation of P2XR, to bring into question the dilated state and to identify a physiological cation that can flow through P2XR. We have also designed a photo-cleavable amino acid which could serve in the study of structure-function relationships
Chatelier, Aurélien. "Modulation des performances cardio-respiratoires du bar européen (Dicentrarchus labrax) par l'apport d'acides gras alimentaires : une étude intégrée des effets cardiaques in vivo au courant calcique de type L des myocytes ventriculaires". La Rochelle, 2005. http://www.theses.fr/2005LAROS148.
Texto completo da fonteDiet fatty acid composition is an environmental factor that is emerging as a significant source of physiological diversity. Heart plays a central role in fish adaptability to their environment. The objective of the study on the sea bass (Dicentrarchus labrax) was to investigate the effects of fatty acids on: cardio-respiratory performances during a swim test and a hypoxic test, L-type calcium channel activity of ventricular myocytes. Sea bass were fed with three different diets enriched in fish oil (n-3 poly-unsaturated fatty acid), canola oil (oleic acid) and palm oil (saturated fatty acid). The study carried out on the whole animal shows that diet and cardiac high level of oleic acid is associated with best cardiac and metabolic performances. The hypoxic test revealed no significant difference between the diets. Studies on L-type calcium channel revealed that both oleic acid perfusion and high membrane content of oleic acid induce a reduction in ventricular myocyte calcium influx. The heart may limit metabolic and swimming performance of fishes. During an intensive muscular challenge, this restriction is due to cardiac hypoxia which leads to a rise in intracellular calcium and to the appearance or cardiac arrhythmias. Results suggest that oleic acid, by decreasing cell calcium entry, limit cardiac arrhythmia occurrence. This protective effect could be responsible of differences observed during the swim test
Mistry, Dineshkumar. "The vertebrate neuronal gamma-aminobutyric acid (GABAa) receptor and its modulation : a patch clamp study". Thesis, University of St Andrews, 1988. http://hdl.handle.net/10023/14452.
Texto completo da fonteSyme, C. A. "Patch-clamp studies on endothelial cell and chromaffin cell K'+ channels : effects of shear stress, membrane stretch and fatty acids". Thesis, University of Strathclyde, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298575.
Texto completo da fonteTatu, Rigwed R. "Development and Characterization of aPoly (l-lactic acid)/ Poly (e-caprolactone) Self-Expanding Patch forFetoscopic Repair of Myelomeningocele". University of Cincinnati / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1535635832679162.
Texto completo da fonteZieren, Jürgen. "Hernienreparationen mit Netzprothesen klinische und experimentelle Untersuchungen". Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2001. http://dx.doi.org/10.18452/13702.
Texto completo da fonteIn a prospective-randomized study conventional Shouldice operation was compared with tension-free procedures using mesh implantation in endoscopic (transabdominal preperitoneal mesh repair, TAPP) and open technique (Plug and patch repair; PP) for inguinal hernia repair. Regarding the mean end point postoperative pain both tension-free procedures (TAPP, PP) revealed significantly better results than Shouldice operation. Complications were comparable between the groups but duration of postoperative restrictions was significantly shorter after both tension-free procedures. To improve mesh quality for tension-free hernia repair an animal experiment was performed using a resorbable polyglycolic acid mesh. Despite good incorporation this mesh shows insufficient tensile strength due to absorption. Application of fibrin glue or platelet releasates significantly improve the mechanical stability of the repair protecting against herniation in this animal model.
Facchin, Andrea. "New path for thermochemical-biological conversion with a power-to-material approach". Master's thesis, Alma Mater Studiorum - Università di Bologna, 2021. http://amslaurea.unibo.it/23117/.
Texto completo da fonteKacem, Hanana Houda. "Établissement de primocultures de cellules cardiaques de palourdes Ruditapes decussatus : étude des courants ioniques et des MAP Kinases après exposition des cellules à des xénoobiotiques". Brest, 2011. http://www.theses.fr/2011BRES2011.
Texto completo da fonteThe necessity to evaluate impact of xenobiotics from aquatic environment in marine organisms justifies the implementation of new bioassays and biomarkers to identify health risks for better prevention. The use of alternative methods to animal experiment, such as cell cultures, is recommended in toxicology. In this context, primary cultures of heart cells from clam Ruditapes decussatus was established and used to evaluate the effects of three types of pollutants from marine environment: a biocide, a phycotoxine and an herbicide. Primary cultures were routinely obtained and maintained functional in vitro for at least one month. Among cells, cardiomyocytes identified by electrophysiological properties after study by patch clamp presents an interest as bioassay for applications in toxicology. Cellular responses evaluated in vitro varie with the pollutant and are time and dose dependent. In particular, study of MAPK signaling pathways (P38, JNK and ERK) are of major interest
Mazza, Alessia Zecca. "The calcium path across the plasma membrane Ca2+-ATPhase : a study by single amino acid mutations /". Zürich, 1999. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=13235.
Texto completo da fonteOzhathil, Lijo Cherian. "A structural and functional insight into TMEM16B, a calcium-activated chloride channel". Doctoral thesis, SISSA, 2014. http://hdl.handle.net/20.500.11767/3921.
Texto completo da fonteBreeze, Liam J. "Cav1.2 pore structure using the substituted-cysteine accessibility method /". Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2006.
Encontre o texto completo da fonteTypescript. Includes bibliographical references (leaves 108-118). Free to UCD Anschutz Medical Campus. Online version available via ProQuest Digital Dissertations;
Manzini, Ivan. "Diversity of transduction mechanisms in receptor neurons of the main olfactory epithelium in Xenopus laevis tadpoles". Doctoral thesis, [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=975110926.
Texto completo da fonteBiet, Michaël. "Rôle et implication du courant sodique cardiaque dans la genèse de phénomènes arythmogéniques en conditions physiopathologiques". Thèse, Université de Sherbrooke, 2015. http://hdl.handle.net/11143/6054.
Texto completo da fonteFrenal, Karine. "Caractérisation structurale et fonctionnelle de TgDRE : une enzyme de réparation de l' ADN du parasite Toxoplasma gondii". Paris 6, 2006. http://www.theses.fr/2006PA066031.
Texto completo da fonteCoussin, Frédéric. "Identification et rôle des récepteurs-canaux à la ryanodine dans la signalisation calcique intracellulaire des myocytes vasculaires : approche par microscopie confocale et oligonucléotides antisens". Bordeaux 2, 2000. http://www.theses.fr/2000BOR28801.
Texto completo da fonteRudolph, Tim Christoph [Verfasser], Lothar [Akademischer Betreuer] Mörl, Waltraud [Akademischer Betreuer] Kahle e Gerald [Akademischer Betreuer] Warnecke. "Model-based stochastic optimization of palm oil deodorization via Short-Path-Distillation towards 3-MCPD fatty acid ester formation and major oil quality parameters / Tim Christoph Rudolph ; Lothar Mörl, Waltraud Kahle, Gerald Warnecke". Magdeburg : Universitätsbibliothek, 2016. http://d-nb.info/1125507993/34.
Texto completo da fonteRudolph, Tim Christoph Verfasser], Lothar [Akademischer Betreuer] [Mörl, Waltraud [Akademischer Betreuer] Kahle e Gerald [Akademischer Betreuer] Warnecke. "Model-based stochastic optimization of palm oil deodorization via Short-Path-Distillation towards 3-MCPD fatty acid ester formation and major oil quality parameters / Tim Christoph Rudolph ; Lothar Mörl, Waltraud Kahle, Gerald Warnecke". Magdeburg : Universitätsbibliothek, 2016. http://d-nb.info/1125507993/34.
Texto completo da fonteIto, Vanessa Mayumi. "Concentração de tocoferois e fitoesterois a partir do destilado desodorizado de oleos vegetais atraves do processo de destilação molecular". [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/267393.
Texto completo da fonteTese (doutorado) - Universidade Estadual de Campinas, Faculdade de Engenharia Quimica
Made available in DSpace on 2018-08-09T17:03:30Z (GMT). No. of bitstreams: 1 Ito_VanessaMayumi_D.pdf: 2213403 bytes, checksum: a16f218d14a3434ec925c550641af635 (MD5) Previous issue date: 2007
Resumo: Resumo: Os tocoferóis e fitoesteróis são componentes minoritários presentes em plantas e óleos vegetais. Os tocoferóis apresentam atividades vitamínicas e propriedades antioxidantes. A vitamina E é composta por 4 tocoferóis (a, b, g e d) e 4 tocotrienóis (a, b, g e d). Os fitoesteróis possuem propriedades anticolesterolêmica e anticarcinogênicas. Uma das principais fontes de tocoferóis e fitoesteróis são os destilados desodorizados de óleos vegetais. Os destilados desodorizados são constituídos de ácidos graxos, triglicerídeos, fitoesteróis, hidrocarbonetos, aldeídos, cetonas, tocoferóis, dentre outros. Neste trabalho foram estudados dois tipos de destiladores moleculares: centrífugo e de filme descendente (agitado). Os destilados desodorizados de óleo de soja, canola e girassol foram processados no destilador molecular de filme descendente. A recuperação de ácidos graxos livres em função da razão entre as vazões das correntes de destilado e de resíduo apresentou o mesmo perfil para os três destilados desodorizados estudados. O destilado desodorizado de óleo de soja, abundante no Brasil, foi processado no destilador molecular centrífugo. O processo de destilação centrífugo foi estudado tanto experimentalmente quanto por simulação. Foi realizado um planejamento fatorial visando analisar o comportamento das variáveis (temperatura do evaporador e vazão de (alimentação). Observou-se que ocorre uma maior eliminação de ácidos graxos livres a altas temperaturas do evaporador e baixas vazões de alimentação. Tanto o processo de destilação molecular de filme descendente quanto o centrífugo duplicaram a concentração inicial de tocoferóis. Através do processo de destilações sucessivas triplicou-se a concentração de tocoferóis e, com destilações sucessivas seguidas de uma etapa de cristalização, quaduplicou-se a concentração de tocoferóis em relação à concentração original
Abstract: Tocopherols and phytosterols are minority compounds present in vegetables oils. Tocopherols show vitaminic activities and antioxidant properties. Vitamin E is composed by four tocopherols (a, b, g and d) and four tocotrienols (a, b, g and d). The phytosterols have anticholesterolemic and anticarcinogenic properties. The main natural sources of tocopherols and phytosterols are the vegetable oil deodorized distillate (VODD). The deodorized distillates are composed by fatty acids, acylglycerols, sterols, hydrocarbons, aldehydes, ketones and tocopherols. In this work, two kinds of molecular distillation equipments were studied: centrifugal and falling film (wiped). The soybean, canola and sunflower oil deodorized distillates were carried out at falling film molecular distilator. The free fatty acids recovery in function of the Distillation mass/Residue mass ratio shows similar behavior to the three VODDs. Soybean oil deodorized distillate, abundant in Brazil, was chosen to be processed in the centrifugal molecular distiller. This centrifugal molecular distillation process was studied experimental and simulated. The factorial design was carried out to analyze the variable behavior (evaporator temperature and feed flow rate). The free fatty acids elimination occurs at higher evaporator temperatures and lower feed flow rate. The falling film and centrifugal molecular distillation process duplicates the tocopherol concentration. Through successive distillations, the tocopherol concentration was three times higher and with the crystallization, the tocopherol concentration was four times in relation to the original concentration
Doutorado
Desenvolvimento de Processos Químicos
Doutor em Engenharia Química
Bertram, Janet. "Effects of cow urine and its constituents on soil microbial populations and nitrous oxide emissions". Diss., Lincoln University, 2009. http://hdl.handle.net/10182/1334.
Texto completo da fonteUrio, Ricardo de Prá. "Cromatografia a líquido por injeção sequencial para a determinação de herbicidas triazínicos e metabólitos da atrazina explorando o uso de cela de longo caminho óptico e monitoramento on-line em estudos de adsorção". Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/46/46136/tde-31082011-143740/.
Texto completo da fonteThis work describes the use of Sequential Injection Liquid Chromatography (SIC) coupled to a long path length optical flow cell with 100 cm long Liquid Core Waveguide (LCW) to improve the limits of detection (LOD) and quantification (LOQ) for determination of atrazine (ATR), propazine (PRO) and simazine (SIM). Separation was achieved with a mobile phase composition of 44:56 (v v-1) methanol:1.25 mM ammonium acetate buffer, pH 4.7, monolithic column and spectrophotometric detection at 238 nm. The values of LOD and LOQ were, respectively, 1.76 and 5.86 µg L-1 for ATR, 4.51 and 15 µg L-1 for PRO and 2.25 and 7.5 µg L-1 for SIM. The LOD values achieved with the employment of long optical path cell were lower than those recommended by US-EPA, which allows for drinking water, maximum concentration levels of 3 µg L-1 for ATR, 4 µg L-1 for SIM and 10 µg L-1 for PRO. Adsorption of SIM, PRO and ATR, as well as their metabolites desisopropylatrazine (DIA), desethylatrazine (DEA) and 2-hidroxyatrazine (HAT) on soil, humic acid and soil modified with humic acidic was studied. An on-line monitoring system was assembled, composed of a tangential filter and a peristaltic pump for circulation of the suspension. Kinetic studies were carried out in two steps, and in both, it was used a mix of compounds with initial concentration of 1,0 mg L-1 and a stepwise gradient elution for separation of the compounds using three mobile phases with compositions of 15 or 28, 40 and 50% (v v-1) methanol: 1.25 mM ammonium acetate buffer, pH 4.7. In the first step the contact time between triazines and adsorbents was 90 minutes. In a second study made only with soil, the contact time was 24 h. Data obtained in the first stage of the study was only fitted to pseudo-second order kinetic equation, which allowed one to estimate the values of the adsorbed mass of triazine per mass of adsorbent. Humic acid was the material with higher adsorptive capacity (from 1470 ± 43 µg g-1 for DIA to 2380 ± 50 µg g-1 for PRO). In soil, PRO exhibited the highest adsorption (26.5 ± 0.1 µg g-1). The presence of humic acid in the soil increased adsorption of ATR (19.4±0.7 to 23±2 µg g-1), HAT (10.9 ± 0.7 to 18 ± 2 µg g-1) and PRO (26.5 ± 0.7 to 29.8 ± 0.2 µg g-1), but decreased adsorption of SIM, not affecting DIA and DEA. In the study with contact time of 24 h, it was possible apply pseudo-first and pseudo-second order equations for SIM, ATR and PRO. The results confirmed the greatest adsorption of PRO, followed by ATR. HAT, SIM, DEA and DIA had low rates of adsorption on soil, the latter two showed a trend of desorption after 4 h of contact, having the greatest potential for leaching to water bodies near to the places of application.
Wong, Ee Nuan, e 黃奕鑾. "Gellan gum/Hyaluronic acid carrier Clioquinol or 5-fluorouracil as the treatment patch of oral cancer". Thesis, 2016. http://ndltd.ncl.edu.tw/handle/65685177401355788013.
Texto completo da fonteKang, Pei-Leun, e 康沛倫. "Hyaluronic Acid/Collagen/Mesenchymal Stem Cells Cardiomyocyte-like Cells Cardiac Patch on the Restoration of Injured Myocardium". Thesis, 2014. http://ndltd.ncl.edu.tw/handle/55251440463832049067.
Texto completo da fonte國立臺灣大學
醫學工程學研究所
102
As well known, cardiomyocytes and neural cells are un-proliferative cells in human. Especially, when the cardiomyocytes damaged, necrotized and loosed its function, the heart is difficult to recover to its original function. To date, in clinical practice, the remedy of this damaged heart is by heart transplantation or heart assist devices. Besides, by implanting regenerative cardiomyocytes into the defect area is now acquiring more attentions from many recent researchers. 5-azacytidine is used to differentiate the mesenchymal stem cells (MSCs) to cardiomyocyte-like cells in these researches. These cardiomyoctye-like cells reveal the spontaneous heart-beat behaviors and with action potentials as normal cardiomyocytes. Type I collagen is the main composition of extracellular matrix. It provides many cellular functions, including providing scaffolds for cells adhesion, migration, differentiation and proliferation. Hyaluronic acid, also possesses biocompatible and biodegradable properties, and used to prepare cell-cultural substrates in tissue engineering applications. The aims (or works) of this study are to prepare 3-D mimetic scaffold (cardiopatch) which be able to provide a natural like micro environment for MSCs growth, to evaluate a chemical stimulant which act as a signal transduction factor, 5-azacytidine is added into the scaffold or medium to stimulate MSCs differentiate to the cardiomyocytes, and to establish animal model with myocardial injury. According to the analysis of water content, porosity and mechanical properties of collagen/hyaluronan composite scaffold, the group composite scaffold (collagen I : HA of 7:1.5) has the maximum elongation. The effect of 5-azacytidine used to induce differentiation of mesenchymal stem cells into cardiomyocyte was positively confirmed by real-time PCR. The results showed that mesenchymal stem cells seeded in composite scaffold expressed higher value of cardiomyocyte specific genes (such as cTnI, β-MHC and α-actin) than the group of cells without using any scaffold but only 5-azacytidine. During the buildup of animal model with myocardial damages, operation was performed to suture the left anterior descending artery and it resulted dark red color change on the distal end of myocardium, biopsy observation also reported that part of myocardium have been replaced with fibroblast with mesenchymal cells alignment or distribution. This proves that by suturing the left anterior descending artery can cause damages to myocardium. The animal study demonstrated that collagen/HA composite scaffolds have the potential for cardiac regeneration applications.
Daniels, Bryan. "Modulation of ionotropic glutamate receptors in retinal neurons by the amino acid D-serine". 2011. http://hdl.handle.net/10222/13296.
Texto completo da fonteAromataris, Edoardo Claudio. "Pharmacology of the CIC-1 chloride channel". 2009. http://hdl.handle.net/2440/58973.
Texto completo da fontehttp://proxy.library.adelaide.edu.au/login?url= http://library.adelaide.edu.au/cgi-bin/Pwebrecon.cgi?BBID=1474724
Thesis (Ph.D.) -- University of Adelaide, School of Molecular and Biomedical Science, 2009
Yu, Ya-Hui, e 游雅惠. "Application of Flush Response to Niacin Skin Patch in Schizophrenia Research: Comparing Visual Rating with Infrared Thermography and Their Relations to Fatty Acids Levels in Blood". Thesis, 2011. http://ndltd.ncl.edu.tw/handle/90272977649091262130.
Texto completo da fonte國立臺灣大學
流行病學與預防醫學研究所
99
Background: Attenuated niacin-induced flush response, a potential endophenotype for schizophrenia, has been postulated to involve a prostaglandin-related microvasodilation pathway where arachidonic acid or other fatty acids may play important roles. However, the correlations between the flush response and the implicated biochemical indexes remained incoherent, either because of different ways in giving niacin challenge test or in the evaluation of response. Alternatively measuring the raising temperature accompanying the niacin-induced flush might serve as an tool to assess the niacin-induced flush response. Objectives: This study aimed to: 1) evaluate the applicability of infrared thermography in measuring the niacin-induced flush response, and 2) examine the relations of the flush magnitude to fatty acids levels in blood. Methods: For the first aim, a pilot study of two groups of subjects were used to clarify the correlation between objectively measured temperature and visually rated flush score, whereas for the second aim another independent sample of psychiatric inpatients as well as healthy controls were used to explore the correlation between temperature, flush and fatty acids levels in red blood cells (RBCs) as well as in plasma. Three concentrations of niacin skin test with forty minute observation by visual rating method and infrared thermography method was performed in the sample of pilot study (31 patients with schizophrenia and 32 normal controls). On the other hand, niacin skin test with fifteen minute observation using both methods and blood fatty acids analysis were performed in the sample of biochemical study (9 patients with schizophrenia, 6 patients with bipolar disorder, and 15 normal controls). Fatty acids compositions of RBC and plasma were analyzed using gas chromatography. Results: Visual rating score method showed group difference in 0.001M while thermography method did not reveal group difference in all concentration and times. The correlations between these two methods were weak. Subjects of biochemical sample were re-grouped as non-flushers versus flushers on the basis of the flush score for 0.01M at 5 minute. The RBC and plasma levels of n-6 fatty acids in non-flushers tended to be lower than the corresponding ones of flushers and the RBC level of EPA was significantly higher in non-flushers than flushers. Conclusions: This study demonstrated that in measuring the niacin-induced flush response the visual rating method is better in discriminating schizophrenia patients from normal controls than the infrared thermography-based temperature rating. Furthermore, our results indicate that non-flushers tended to have lower levels of n-6 fatty acids but higher EPA levels than flushers. Future investigation is warranted to further explore the physiological abnormalities associated with the attenuated flush response in schizophrenia patients.
Aromataris, Edoardo Claudio. "Pharmacology of the CIC-1 chloride channel". Thesis, 2009. http://hdl.handle.net/2440/58973.
Texto completo da fonteThesis (Ph.D.) -- University of Adelaide, School of Molecular and Biomedical Science, 2009
Chamberlain, S. E., I. M. Gonzàlez-Gonzàlez, K. A. Wilkinson, F. A. Konopacki, Sriharsha Kantamneni, J. M. Henley e J. R. Mellor. "SUMOylation and phosphorylation of GluK2 regulate kainate receptor trafficking and synaptic plasticity". 2012. http://hdl.handle.net/10454/5911.
Texto completo da fontePhosphorylation or SUMOylation of the kainate receptor (KAR) subunit GluK2 have both individually been shown to regulate KAR surface expression. However, it is unknown whether phosphorylation and SUMOylation of GluK2 are important for activity-dependent KAR synaptic plasticity. We found that protein kinase C-mediated phosphorylation of GluK2 at serine 868 promotes GluK2 SUMOylation at lysine 886 and that both of these events are necessary for the internalization of GluK2-containing KARs that occurs during long-term depression of KAR-mediated synaptic transmission at rat hippocampal mossy fiber synapses. Conversely, phosphorylation of GluK2 at serine 868 in the absence of SUMOylation led to an increase in KAR surface expression by facilitating receptor recycling between endosomal compartments and the plasma membrane. Our results suggest a role for the dynamic control of synaptic SUMOylation in the regulation of KAR synaptic transmission and plasticity.