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Liu, Huan, Yong-Ming Yan, Li Liao, Shao-Xiang Wang, Yi Zhang e Yong-Xian Cheng. "Cicadamides A and B, N-Acetyldopamine Dimers From the Insect Periostracum cicadae". Natural Product Communications 14, n.º 6 (junho de 2019): 1934578X1985001. http://dx.doi.org/10.1177/1934578x19850019.
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Two new N-acetyldopamine dimers, cicadamides A (1) and B (2), and 8 known compounds were isolated from the medicinal insect Periostracum cicadae. Their structures including absolute configurations were assigned by spectroscopic and computational methods. Biological activities of compounds 1, (+)-2, and (–)-2 toward human cancer cells BGC-823, HepG2, and A549 were evaluated.
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Chen, Zhou, Dan Hong, Siting Li e Yingmin Jia. "Novel Property Cytotoxicity and Mechanism of Food Preservative Brevilaterins against Human Gastric Cancer Cells". Foods 12, n.º 8 (21 de abril de 2023): 1732. http://dx.doi.org/10.3390/foods12081732.
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Brevilaterins, antimicrobial peptides produced by Brevibacillus laterosporus, are regarded as excellent food preservatives and are popular as antimicrobial applications. Recent research has uncovered their potent cytotoxic effects against diverse cancer cells, thereby underscoring the pressing need for more extensive and intensive investigations into this use. In this study, we explored their novel function in inducing cytotoxicity to cancer cells and systematically investigated the mechanism of action of Brevilaterin B/C (BB/BC) in vivo. Proliferation, membrane permeability, and apoptotic rate were evaluated using CCK-8 assay, LDH assay, and Annexin V-FITC/PI kits. ROS levels and mitochondrial membrane potential were detected using the fluorescent probe DCFH-DA and JC-1. Our results demonstrated that both BB and BC at concentrations of 4–6 µg/mL significantly inhibited the proliferation and migration of gastric cancer cells BGC-823. Treatment with 4 µg/mL of BB/BC rapidly increased LDH levels in the supernatant of BGC-823 cells, leading to further investigation of the mechanism of apoptosis. We found that the apoptotic rate of BGC-823 cells significantly increased upon treatment with BB/BC, demonstrating their potent induction of apoptosis. BB/BC-induced ROS production in BGC-823 cells impaired their growth and induced apoptosis, indicating a close association between apoptosis and ROS elevation. Additionally, JC-1 aggregates rapidly accumulated after treatment with 4 µg/mL of BB/BC, suggesting changes in mitochondrial membrane potential and early apoptosis. Taken together, our findings revealed that BB and BC exhibit significant anticancer effects against gastric cancer cells, highlighting the promising potential of Brevilaterins as anticancer agents.
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He, Wen Jun, Zhao Hui Fu, Hong Jin Han, He Yan, Guang Zhi Zeng, Chang Jiu Ji, Hong Biao Chu, Yu Mei Zhang e Ning Hua Tan. "Benzoic Acid Allopyranosides and Lignan Glycosides from the Twigs of Keteleeria evelyniana". Zeitschrift für Naturforschung B 66, n.º 7 (1 de julho de 2011): 733–39. http://dx.doi.org/10.1515/znb-2011-0715.
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Seven new compounds, including three benzoic acid allopyranosides keteleeroside A (1), keteleeroside B (2) and keteleeroside C (3), and four lignan glycosides 3’-demethylicariside E3 (4), isocupressoside B (5), 3-methoxyisocupressoside B (6), and isomassonianoside B (7), along with five known compounds (8 - 12), were isolated from the n-butanol part of the methanolic extract of the twigs of Keteleeria evelyniana. The structures of these compounds were elucidated mainly by the analysis of their NMR and MS data. All compounds were isolated from this genus for the first time. The skeleton of lignan glycoside 4 was isolated from the Pinaceae family for the first time. All compounds were evaluated for antimicrobial activity against Candida albicans and Staphylococcus aureus, and their cytotoxic activity against K562, HT-29, B16, BGC-823, BEL-7402, SGC-7901, U251, and A549 cancer cell lines was studied. Results indicated that none of the compounds showed antimicrobial or cytotoxic activity.
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Norikawa, Yutaro, Kouji Yasuda e Toshiyuki Nohira. "Effect of Temperature on Grain Growth during Ti Electrodeposition in Lif–LiCl Eutectic Melt". ECS Meeting Abstracts MA2022-01, n.º 23 (7 de julho de 2022): 1197. http://dx.doi.org/10.1149/ma2022-01231197mtgabs.
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1. Introduction Ti has superior properties, such as high specific strength, corrosion resistance, biocompatibility, and is used for many fields such as airplane, chemical plant, consumer products. However, its high manufacturing cost and poor processability have hindered its further spread. Thus, a number of smelting processes and processing methods have been investigated to reduce the cost and spread the use of Ti. Among them, plating Ti metal on inexpensive substrates is one of the methods that can utilize the surface properties of Ti. Electrodeposition is a promising plating method from the viewpoints of the cost and the flexibility in shape of substrate. Therefore, electrodeposition of Ti metal in high-temperature molten salts has been investigated for a long time [1–3]. Our group has reported the electrodeposition of Ti films with compact and smooth surfaces in molten KF–KCl and LiF–LiCl containing Ti(III) ions at 923 K [4–7]. We also reported that the Ti films obtained in LiF–LiCl at 823 K had smoother surfaces [8]. In the present study, we investigated the effect of temperature on the grain growth and smoothness of Ti films electrodeposited in LiF–LiCl eutectic melt at 823–973 K. 2. Experimental The experiments were carried out in eutectic LiF–LiCl melt (30:70 mol%, melting point 774 K) at 823–973 K. The melt was placed in a nickel crucible and the experiments were conducted in an airtight Kanthal container in an argon glove box. As Ti(III) ion sources, Li2TiF6 (2.00 mol%) and Ti sponge (1.33 mol%) were added to the melt. The added amounts of Ti sponge were twice the amounts necessary to generate Ti(III) ions by comproportionation reaction between Ti(IV) ions and Ti(0) according to Eq. 1. Ti(0) + 3Ti(IV) → 4Ti(III) (1) Ni plates were used as working electrodes, and Ti rods was used as counter and reference electrodes. The samples prepared by galvanostatic electrolysis were analyzed by XRD and SEM/EDX after washing with distilled water to remove adhered salts. 3. Results and Discussion Fig. 1 shows the optical and surface SEM images of the samples obtained by galvanostatic electrolysis at 823, 873, 923, and 973 K. The cathodic current density was 50 mA cm−2 and electrolysis time was 20 min. All the samples have a metallic luster and are confirmed to be Ti metal by XRD analysis. However, the brightness differs between samples, with the Ti film at 823 K showing the highest brightness. From the surface SEM images, the crystal grain size of Ti increases as the temperature rises. This tendency is reasonably explained by previous work on the temperature dependence on grain growth of Ti [9]. Also, the value of surface roughness (Sa) measured by SEM increases as the temperature increases. The smoothest Ti film with Sa = 2.05 ± 0.22 μm was obtained at 823 K. These results show that Ti film with smoother surface can be electrodeposited by suppressing the grain growth of Ti at lower temperatures. To obtain thicker films, electrolysis was conducted for longer time at 823 K, where grain growth is suppressed. Fig. 2 shows the optical and SEM images of the samples obtained by galvanostatic electrolysis at a cathodic current density of 50 mA cm−2 and charge densities of 60, 150, and 450 C cm−2. As shown in the SEM images, the thickness of the Ti film increases with the increase in charge density. Although some deposition onto the edge was observed at 450 C cm−2, the thickness of the Ti film reaches 100 μm. Acknowledgement A part of this work was supported by JSPS Fellows grant number 19J15015. A part of this study was conducted as a collaboration with Sumitomo Electric Industries, Ltd. The present address of Kouji Yasuda is Graduate School of Engineering, Kyoto Univ. References [1] D. Wei, M. Okido, and T. Oki, J. Appl. Electrochem., 24, 923 (1994). [2] A. Robin and R. B. Ribeiro, J. Appl. Electrochem., 30, 239 (2000). [3] V. V. Malyshev and D. B. Shakhnin, Mater. Sci., 50, 80 (2014) [4] Y. Norikawa, K. Yasuda, and T. Nohira, Mater. Trans., 58, 390 (2017). [5] Y. Norikawa, K. Yasuda, and T. Nohira, Electrochemistry, 86, 99 (2018). [6] Y. Norikawa, K. Yasuda, and T. Nohira, J. Electrochem. Soc., 166, D755 (2019). [7] Y. Norikawa, K. Yasuda, and T. Nohira, J. Electrochem. Soc., 167, 082502 (2020). [8] M. Unoki, Y. Norikawa, K. Yasuda, and T. Nohira, ECS Trans., 98, 393 (2020) [9] K. Okazaki and H. Conrad, Metall. Trans., 3, 2411 (1972). Figure 1
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Rybin, Mikhail V., e Mikhail F. Limonov. "Once again about supercavity modes (a response to the letter to the editors of Physics-Uspekhi from V.V. Klimov [Phys. Usp. 62 (10) (2019); Usp. Fiz. Nauk 189 (10) 1131 (2019)] with comments on the review by M.V. Rybin and M.F. Limonov "Resonance effects in photonic crystals and metamaterials" [Phys. Usp. 62 (8) 823 (2019); Usp. Fiz. Nauk 189 (8) 881 (2019)])". Uspekhi Fizicheskih Nauk 189, n.º 12 (outubro de 2019): 1364–66. http://dx.doi.org/10.3367/ufnr.2019.10.038679.
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Batool, Samana, Thomson Joseph, Mushraf Hussain, Miza Vuai, Kavish Khinsar, Syed Din, Arshad Padhiar et al. "LP1 from Lentinula edodes C91-3 Induces Autophagy, Apoptosis and Reduces Metastasis in Human Gastric Cancer Cell Line SGC-7901". International Journal of Molecular Sciences 19, n.º 10 (30 de setembro de 2018): 2986. http://dx.doi.org/10.3390/ijms19102986.
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Present study aimed to elucidate the anticancer effect and the possible molecular mechanism underlying the action of Latcripin 1 (LP1), from the mushroom Lentinula edodes strain C91-3 against gastric cancer cell lines SGC-7901 and BGC-823. Cell viability was measured by Cell Counting Kit-8 (CCK-8); morphological changes were observed by phase contrast microscope; autophagy was determined by transmission electron microscope and fluorescence microscope. Apoptosis and cell cycle were assessed by flow cytometer; wound-healing, transwell migration and invasion assays were performed to investigate the effect of LP1 on gastric cancer cell’s migration and invasion. Herein, we found that LP1 resulted in the induction of autophagy by the formation of autophagosomes and conversion of light chain 3 (LC3I into LC3II. LP1 up-regulated the expression level of autophagy-related gene (Atg7, Atg5, Atg12, Atg14) and Beclin1; increased and decreased the expression level of pro-apoptotic (Bax) and anti-apoptotic (Bcl-2) proteins respectively, along with the activation of Caspase-3. At lower-doses, LP1 have shown to arrest cells in the S phase of the cell cycle and decreased the expression level of matrix metalloproteinase MMP-2 and MMP-9. In addition, it has also been shown to regulate the phosphorylation of one of the most hampered gastric cancer pathway, that is, protein kinase B/mammalian target of rapamycin (Akt/mTOR) channel and resulted in cell death. These findings suggested LP1 as a potential natural anti-cancer agent, for exploring the gastric cancer therapies and as a contender for further in vitro and in vivo investigations.
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Varotto, Elena, Margarita Maurer-Granofszky, Daniela Silvestri, Pamela Scarparo, Ester Mejstrikova, Monika Brüggemann, Giovanni Cazzaniga et al. "Transient Switch to Myeloid Lineage in Acute Lymphoblastic Leukemia during Induction Therapy: The Role of CD371 Expression and Implication for Minimal Residual Disease Detection". Blood 134, Supplement_1 (13 de novembro de 2019): 377. http://dx.doi.org/10.1182/blood-2019-127287.
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Background Multiparametric flow cytometry (MFC) is critical in the diagnosis and management of pediatric acute lymphoblastic leukemia (ALL), through immunophenotyping (IP), and minimal residual disease (MFC MRD) analysis. The aberrant expression of myeloid markers in B- and T-lineage ALL is a well-known phenomenon. It may be the result of an adaptive mechanism by lineage switch (SW), defined as any variation of blast IP over time. CD371 is a transmembrane glycoprotein usually expressed on normal myeloid cells and most of the myeloid blasts. Aberrant expression of CD371 was observed in DUX4-rearranged B cell precursor ALL (BCP ALL). Aims To investigate the clinical and biological features of CD371 positive (CD371+) pediatric BCP ALL, pointing out its potential implication in MFC MRD monitoring on Day 15. Materials and Methods From June 2014 to January 2017, 862 children with newly diagnosed t(9;22)(q34.1;11.2);BCR-ABL1 negative BCP ALL, were consecutively enrolled in the AIEOP BFM ALL 2009 study by AIEOP centers. Peripheral blood (PB) and bone marrow (BM) samples (SMPs) were processed and analyzed in the Laboratory of Diagnosis and Research of Pediatric Hematology-Oncology, University of Padua, Italy, according to standardized operating protocols designed by the AIEOP BFM Flow Network. At diagnosis, 9 combinations of 8 monoclonal antibodies (MoAbs) were used for IP. MFC MRD (Day 8 on PB, Day 15, 33, and 78 on BM) was performed with 2 combinations of 8 MoAbs from June 2014 to May 2016. Later, a dry 10 colors preformulated tube was adopted for MFC MRD monitoring. Results At diagnosis, CD371 expression was assessed in 823 of 862 (95.5%) SMPs by as many patients (pts; age: 1-17 years; male/female: 446/377). Of those, CD371 was positive in 75 of 823 SMPs (9.1%). CD371 positivity was associated with older age, euploidy, a more immature immunophenotype (B-I as per EGIL classification), and the aberrant expression of CD2 antigen, as well as at least one myeloid marker (Table). CD371+ SMPs showed a stronger expression of CD34, CD45, and CD58 antigens than CD371 negative SMPs (Table). We performed MFC MRD analysis on 207 SMPs of CD371+ BCP ALL (42 on Day 8, 72 on Day 15, 40 on Day 33, and 53 on Day 78). During the first 15 days of Induction therapy, a monocytoid population appeared in 76 SMPs [26 of 42 (61.9%) on Day 8 and 50 of 72 (69.4%) on Day 15]. It was characterized by a strong expression of CD34, CD58 and CD45, reduced expression of CD19, and high SSC. We interpreted that phenomenon as an SW to the myelomonocytic lineage, as previously described in a subtype of BCP ALL expressing CD2 at diagnosis. Myelomonocytic SW displayed 2 different patterns: (a) a single population of blasts with heterogeneous expression of CD19 (strong to dim/negative); (b) 2 distinct populations: the first one with the IP of diagnosis, the second one showing a downregulation of CD19 and CD34, an intensification of CD45, and an increase of SSC (Figure). At the same time points, a clear monocytoid population was visible on May-Grunwald-Giemsa stained smears. The comparison between MFC MRD and PCR MRD data showed a higher concordance when both the populations were included in the final amount of blasts on Day 15 (concordance rate: 89% vs. 82%). SW was transient and disappeared after Day 15, even though chemotherapy was always carried on as per therapeutic ALL protocol. CD371 antigen was an accurate marker of SW in our cohort [sensitivity = 0.93 (95% CI ± 0.06), specificity = 0.98 (95% CI ± 0.005), accuracy = 0.98]. Finally, CD371 positivity was associated with a worse response to Induction therapy, showing a higher proportion of pts enrolled in the high therapeutic risk group of the trial, most frequently due to a slow early response according to PCR MRD on Day 33 and 78 (Table). Conclusions We described a new subtype of pediatric BCP ALL, characterized by the aberrant expression of CD371 and a potential myelomonocytic SW during the first phase of Induction Therapy. Accurate identification of the lineage SW is mandatory to properly assess MFC MRD on Day 15 in these pts, avoiding an underestimation of blast cells. This is particularly important, considering that CD371+ BCP ALL was associated with a poor response to Induction therapy. Even in presence of a prevalent monocytoid population, chemotherapy should be carried on according to a therapeutic protocol for ALL. CD371 antigen should be part of IP diagnosis panel for ALL. A multicenter study of AIEOP BFM Flow Network centers is ongoing. Disclosures Brüggemann: Amgen: Membership on an entity's Board of Directors or advisory committees; Incyte: Membership on an entity's Board of Directors or advisory committees; Roche: Consultancy.
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Barlow, R., H. Hearnshaw, P. F. Arthur e R. E. Darnell. "Evaluation of Hereford and first-cross cows on three pasture systems. I. Calf growth and reproductive performance of young cows". Journal of Agricultural Science 122, n.º 1 (fevereiro de 1994): 121–29. http://dx.doi.org/10.1017/s0021859600065862.
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SUMMARYHereford (H × H), Brahman × Hereford (B × H), Simmental × Hereford (S × H) and Friesian × Hereford (F × H) females born over a 5-year period (1973–77) were placed on pastures of high, medium or low nutritive value at Grafton, New South Wales, Australia, at weaning (7–8 months of age). The first mating of heifers on high pasture was at 15 months (1974) while that on medium and low pastures was delayed until 27 months of age (1975). This paper reports the reproductive performance of these cows up to 5 years of age and the preweaning growth of their calves which were sired by Hereford bulls at Grafton, Australia. In total, 1222 calving records were analysed.Most traits were subject to interaction between genotype and other main effects (pasture, year of birth of cow, cow age and sex of calf). Eyelid pigmentation was an exception, with calves from B × H cows having more than calves of other genotypes (73 v. 43%). There were significant genotype differences in calving difficulty among 2-year-old heifers only, with H × H (33%) requiring more assistance than F × H (15%) and SxH (10%) heifers, while B × H heifers did not require any assistance. Genotype differences in percentage of calves born and weaned were observed on low pastures only, where B × H (66% born, 65% weaned) exceeded H × H (48%, 39%) and S × H (39%, 38%) cows, with F × H (58%, 50%) cows being intermediate. Calves by H × H cows were the slowest-growing and were the lightest at weaning on all pastures, with mean gains of 759, 604 and 340 g/day, and mean weaning weights of 212, 188 and 110 kg, on high, medium and low quality pastures, respectively. F × H and S × H cows produced the fastest-growing calves on high quality pasture (966 and 936 g/day, respectively) while B × H cows produced the fastest-growing calves on medium (823 g/day) and low (679 g/day) quality pastures. F × H cows weaned the heaviest calves on high quality pasture (274 kg) while F × H and B × H weaned the heaviest calves on medium (230 and 229 kg, respectively) and low (162 and 169 kg, respectively) quality pastures. Differences in body measurements followed a pattern similar to weaning weight.
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Antolić, A., B. Kojić-Prodić, S. Tomić, B. Nigović, V. Magnus e J. D. Cohen. "Structural studies on monofluorinated derivatives of the phytohormone indole-3-acetic acid (auxin)". Acta Crystallographica Section B Structural Science 52, n.º 4 (1 de agosto de 1996): 651–61. http://dx.doi.org/10.1107/s0108768195016302.
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As part of the molecular recognition studies on the phytohormone indole-3-acetic acid (IAA) a series of fluorinated IAA's has been examined. The phenyl ring substitution at positions 4, 5, 6 and 7 resulted in four compounds, which were analyzed. Structure–activity correlation includes the analysis of their molecular conformations, based on the X-ray diffraction and computational chemistry results, and bioactivity determinations in the Avena coleoptile and the Pisum sativum stem straight-growth tests, lipophilicity and UV absorbance. The conformations of monofluorinated IAA's and a free hormone are defined by rotations about two bonds: one describes the relative orientation of a side chain towards the indole plane and the second the orientation of the carboxylic group. The results of X-ray structure analysis revealed the folded shape of the molecules in all compounds studied. Molecular mechanics and dynamics located the folded conformation as the local minimum, but failed to detect the planar conformation as one of the local minima, which according to ab initio results on IAA and 4-CI-IAA could also be possible. Crystal data at 295 K for 4-F-IAA and at 297 K for 5-F-IAA, and at 100 K for 6-F-IAA and 7-F-IAA using Mo Kα radiation (λ = 0.71073 Å) and Cu Kα (λ = 1.5418 Å, for 7-F-IAA), are as follows: 4-F-IAA, C10H8NO2F, Mr = 193.18, monoclinic, C2/c, a = 17.294 (5), b = 13.875 (4), c = 7.442 (4) Å, β = 103.88 (6)°, V = 1734 (1) Å3, Z = 8, Dx = 1.480 g cm−3, μ = 1.1 cm−1, F(000) = 800, R = 0.043, wR = 0.044 for 823 symmetry-independent [I ≥ 3σ(I)] reflections; 5-F-IAA, C10H8NO2F, monoclinic, P21/c, a = 19.284 (5), b = 5.083 (4), c = 9.939 (4) Å, β = 117.28 (6)°, V = 865.9 (1) Å3, Z = 4, Dx = 1.482 g cm−3, μ = 1.1 cm−1, F(000) = 400, R = 0.062, wR = 0.057 for 729 symmetry-independent [I ≥ 3σ(I)] reflections; 6-F-IAA, C10H8NO2F, monoclinic, P21/a, a = 9.360 (1), b = 5.167 (4), c = 17.751 (4) Å, β = 93.75 (1)°, V = 856.7 (8) Å3, Z = 4, Dx = 1.498 g cm−3, μ = 1.1 cm−1, F(000) = 400, R = 0.048, wR = 0.048 for 1032 symmetry-independent [I ≥ 2σ(I)] reflections; 7-F-IAA, C10H8NO2F, monoclinic, P21/a, a = 9.935 (5), b = 5.0059 (4), c = 17.610 (1) Å, β = 102.13 (1)°, V = 856.3 (1) Å3, Z = 4, Dx = 1.498 g cm−3, μ = 9.8 cm−1 (Cu Kα, F(000) = 400, R = 0.035, wR = 0.040 for 1504 symmetry-independent [I ≥ 2σ(I)] reflections.
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Foran, James M., Theresa H. Keegan, Christina A. Clarke e Sandra J. Horning. "The Impact of Race and Socioeconomic Status (SES) on Survival in Non-Hodgkin’s Lymphoma (NHL): A Population-Based Study from the California Cancer Registry (CCR)." Blood 110, n.º 11 (16 de novembro de 2007): 3580. http://dx.doi.org/10.1182/blood.v110.11.3580.3580.
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Abstract Background: Despite the existence of well-established clinical prognostic indices for diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL), the 2 most common subtypes of NHL, significant heterogeneity in survival remains even within prognostic groups. SES has not previously been evaluated as a prognostic factor for NHL, particularly using an unselected patient population. We therefore used the large multiethnic CCR to examine NHL survival according to histology, race/ethnicity and neighborhood SES. Methods: NHL pts were identified from the CCR for the period 1988–97 using standardized ICD-0-3 classifications (morphology codes 9690–99 for FL & 9680–84 for DLBCL). Patients with evidence of HIV/AIDS were excluded. Neighborhood SES was assigned based on the address of residence at diagnosis, according to 1990 US Census Bureau census block group (each block contains about 1500 residents), and is based upon principal components of 7 indicator variables of SES (education level, proportion with blue collar job, proportion unemployed, median household income, proportion below 200% of poverty line, median rent & median home value). Using this index, we assigned each patient into an SES quintile (SES-1 lowest, SES-5 highest) based on the statewide distribution of neighborhood SES. We computed 5-year relative survival ± standard error (SE) with SEER*Stat software using customized race and SES-specific life tables based on US Census Bureau estimates for California residents. Results: Unselected DLBCL pts [n=13,604; comprising 73% non-Hispanic White (W), 4% Black (B), 14% Hispanic (H), 8% Asian/Pacific Islander (A)] & FL pts (n=7372; 82% W, 3% B, 11% H, 4% A) were identified. The overall 5 yr relative survival for DLBCL was 45.5% (SE 0.5) and for FL was 71.1% (SE 0.6); females had a better survival than males for DLBCL [F 48.3% (SE 0.7) vs. M 42.3% (SE 0.6)] but not for FL. Lower SES was associated with inferior survival for both DLBCL & FL (Table 1). Within SES groups there were not significant racial/ethnic differences in survival. However, in DLBCL, B (34%) and H (33%) pts were proportionally more likely to be in SES-1 than W (9%) or A pts (15%), and less likely to be in SES-5 (9% B, 10% H) than W (27%) or A (22%) pts. Similarly, in FL, B (39%) & H (26%) pts were also more likely than W (8%) & A (10%) pts to be in SES-1 and less likely to be in SES-5 (W-29%, A-32%, B-10%, H-11%). Conclusion: SES predicts survival in DLBCL and FL. Race/ethnicity differences in SES distribution are apparent in NHL patients, but when stratified by SES, race/ethnicity does not appear to predict for significant differences in NHL survival. 5 Year Relative Survival in DLBCL & FL by SES & Race SES-1 (%) SE (%) n SES-5 (%) SE (%) n W-non-Hispanic White; A-Asian/Pacific Islander; B-Black; H-Hispanic DLBCL 40.6 1.3 1905 49.4 1.0 3192 W 38.4 1.9 915 49.4 1.1 2701 A 44.0 4.2 168 48.2 3.5 244 B 45.0 4.2 185 54.3 7.3 51 H 41.6 2.1 637 48.9 4.0 196 FL 66.4 2.1 823 76.6 1.2 1959 W 66.3 2.7 502 77.1 1.2 1753 A 65.4 10.0 30 72.0 5.0 93 B 69.1 6.5 85 76.1 10.0 22 H 65.9 3.8 206 71.8 5.4 91
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Namiki, T., Y. Aoki, Y. Yamada, T. D. Matsuda, H. Sugawara e H. Sato. "Erratum to “La-substitution study on filled-skutterudite PrFe4P12” [Physica B 312–313 (2002) 825–826]". Physica B: Condensed Matter 324, n.º 1-4 (novembro de 2002): 430. http://dx.doi.org/10.1016/s0921-4526(02)01533-8.
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Shaw, Bronwen E., Jenny L. Byrne, Emma Das-Gupta, Ian Carter e Nigel H. Russell. "Converting Mixed Chimerism to Full Donor Chimerism in Recipients of Campath-Containing Reduced Intensity Transplants Reduces the Relapse Risk and Results in Significantly Improved Survival Compared to Those with Persistent Full Donor Chimerism." Blood 106, n.º 11 (16 de novembro de 2005): 2026. http://dx.doi.org/10.1182/blood.v106.11.2026.2026.
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Abstract Donor leucocyte infusions (DLI) are frequently required following reduced intensity conditioned (RIC) allografts to convert mixed donor chimerism (MC) to full donor chimerism (FDC). The rationale is to prevent tolerance developing and therefore to maximise the graft versus tumour (GvT) responses. However, the impact that the chimeric state has on disease relapse and transplant outcome remains controversial. To address this we analysed the impact of the complete (global) chimerism pattern in 125 recipients of RIC transplants. The transplants were performed for a broad range of malignant haematological diseases. Conditioning regimens consisted of fludarabine, melphalan, campath (65), fludarabine, busulphan, campath (13), BEAM, campath +/− fludarabine (38) and other (9). The donors were HLA matched siblings (62, 50%), HLA mismatched siblings (6, 5%), matched unrelated (29, 23%) and mismatched unrelated (28, 22%). The median patient age was 52 and donor age was 42. The median follow up was 823 days (range 99–2674). Four patterns of chimerism were seen: A. always 100% donor chimerism (68, 54%), B. persisting MC post transplant including cases refractory to DLI (27, 22%) C. MC post transplant with subsequently development of FDC either spontaneously or post DLI (22, 18%), D. lost DC and had autologous reconstitution (8, 6%). A number of patients in both groups B and C had FDC early post transplant. In group A 18 (26%) patients received DLI for relapse or residual disease. A complete response was achieved in 6 (35%). In group B 10 (37%) patients had DLI: 4 for MC, 1 for residual disease, 2 for relapse and 3 for both MC and relapse; only partial responses were seen (20%). In group C DLI was given in 14 (64%) patients: 4 for MC, 5 for residual disease, 3 for relapse and 2 for both MC and relapse. A complete response was achieved in 12 (86%). The risk of relapse at 2 years was significantly associated with the pattern of chimerism (p=0.012) and was greatest for group D (75%). Patients in group C (DLI responders) had a relapse rate of 24% compared to 61% in group B (DLI non-responders). In group A it was 37%. This resulted in a significant survival advantage for patients in group C as compared to all other groups (p=0.009). Predicted overall survival at 2 years was 95% in group C, but 54% in group A, 57% in group B, and 58% in group D. We conclude that patients with MC who later achieve FDC have a lower incidence of disease relapse than those with persistent MC, supporting the use of DLI in this group. However the observation that the patients receiving DLI to achieve FDC have a superior outcome to those patients with persistent FDC (group A) suggests that this group may have benefited from a GvT effect against minimal residual disease. The use of pre-emptive DLI in this group (despite FDC) may reduce the risk of relapse and improve transplant outcome.
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Magro, Elena, Rosa Gonzalo-Daganzo, Trinidad Martin-Donaire, Rocio Sanchez, Nuria Panadero, Rafael Cabrera, Carmen Regidor et al. "Single Unit Cord Blood Transplant Supported by Third Party Highly Purified Mobilized Hematopoietic Stem Cells: Immune Reconstitution Studies." Blood 108, n.º 11 (16 de novembro de 2006): 311. http://dx.doi.org/10.1182/blood.v108.11.311.311.
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Abstract Background and Objectives: Following cord blood transplants (CBT) there is a period of severe and often prolonged immune deficiency that results in long term susceptibility to infections. Immune reconstitution is an important factor for long term survival. We analyzed the immune reconstitution of adult recipients of a single unit CBTs supported by a low number of third party donor highly purified mobilized hematopoietic stem cells (dual CB/TPD transplants), as previously described (Magro et al. Haematologica2006;91:640–8). This strategy results in transient double chimerism of CB and TPD cells and early granulocyte recovery, initially of TPD predominance. Complete CB chimerism is regularly achieved within 100 days.The objective of this study is to evaluate immune reconstitution in this CBT. Patients and Methods: Data were obtained from 19 patients between July 2004 and July 2006. Data collection was initiated at different intervals (from day −7 to +720, quartiles Q1=35, Q2=90 and Q3=210). Samples were obtained on days +15, +35, +55, +90 and monthly thereafter up to two years. By four-color flow cytometric immunophenotyping we analyzed the subsets of peripheral blood lymphocytes: CD3+/CD4+ (T helper/inducer), CD3+/CD8+ (T suppressor/cytotoxic), NK cells (CD3−/CD56+/CD16+) and B cells, as well as cells with naïve, memory and effector T-cell immunophenotypes. TREC bearing cells were analyzed by quantitative PCR in sorted CD4+ and CD8+ T cells collected from 3 months post-transplant onwards. Results: CD56+ cells recovered early after transplantation, with median absolute number counts (ANC) of 69 (range 18–307), 170 (0–366) and 159 (32–531) cells/uL in days +15, +35 and +55 samples [normal controls 153 (71–438)], representing the largest subset within the first two months (decreasing proportions of 60%, 50% and 40%, respectively). ANC of CD4 and CD8 T cells remained low for several months, progressively increasing to reach normal ranges at different intervals. Naïve CD4 and CD8 cells (CD45RO−/CD27+) start to be detected by immunophenotyping after three months post-transplantation with median ANC of 17 (12–79) and 12 (5–103) cells/uL respectively and increasing thereafter [normal controls 860 (552–1072) and 331 (227–521)]. By the end of the first year values of T cell subsets were: CD4+, 823 (16–1123) cells/uL [normal controls 872 (470–1093)]; CD8 934 (56–1174) [normal controls 371 (208–808)], with persisting predominance of the naive phenotypes and proportions of memory phenotypes slowly increasing. B cells became detectable around day +90 with median ANC of 249 (0–1934) cells/uL, rapidly reaching values within the normal range [275 (133–684)]. Transient acute GVHD was developed by six of the 19 patients. All showed a transient drop in absolute numbers of NK, T and B cells. Chimerism analysis showed initial transient double chimerism of CB and TPD cells. Complete CB chimerism was achieved between days +15 and +94 (median, +35). Results of chimerism of lymphocyte subsets and TREC are not yet available. Conclusions: Following dual CB/TPD transplants we have observed early recovery of NK and B-cells and slow development of T cells subsets and of non-naive immunophenotypes.
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Adamchuk, T. V., A. P. Hrynko, Т. І. Moroz, O. A. Makarova, N. О. Stadnichuk, H. А. Demich, Т. О. Shchutska e О. М. Holinko. "Regulation and determination of the content of polycyclic aromatic hydrocarbons in food products". One Health and Nutrition Problems of Ukraine 52, n.º 1 (24 de junho de 2020): 5–11. http://dx.doi.org/10.33273/2663-9726-2020-52-1-5-11.
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Objectives. To conduct analysis of PAH findings obtained by different international research organizations and institutions. To compare European and Ukrainian laws regulating contamination of food with PAH. Methods and Materials. Analysis of scientific sources and European and Ukrainian legal acts regulating contamination of food with PAH. Research on contamination of food with PAH. Results and Discussion. According to European Food Safety Authority findings (2008) a total of 9714 foodstuff samples were investigated for one or more 16 priority PAH concentration. Results for the full set of 16 PAH were reported in 823 foodstuff samples, for 15 SCF priority PAH – in 1375 samples, and PAH 8 – in 4065 samples. Benzo[a]pyrene was detected in approximately 50% of all samples tested, ranging from not detected to 100% depending on the foodstuff group involved. In about 30% of samples tested for SCF priority PAH the carcinogenic and genotoxic PAH were detected despite the negative test results for benzo[a]pyrene. The CONTAM Panel came to a conclusion that benzo[a]pyrene is not an unconditional indicator of PAH occurrence in foodstuffs. Based on currently available data concerning PAH occurrence and toxicity, the CONTAM Panel concluded that PAH4 (benzo[a]pyrene, benz[a]anthracene, benzo[b]fluoranthene, chrysene) and PAH8 (benzo[a]pyrene, benz[a]anthracene, benzo[b]fluoranthene, benzo[k]fluoranthene, benzo[ghi]perylene, chrysene, dibenz[a,h]anthracene and indeno[1,2,3-cd]pyrene constitute the most indicative PAH in foodstuffs with PAH8 not providing much added value compared to PAH4. The findings of the research conducted at the Research Center of Toxicology revealed that benzo[a]pyrene content in two samples of sunflower oil exceeded its maximum level. The PAH content in the unrefined crude soybean oil test sample exceeded the maximum level for both benzo[a]pyrene and the sum of three PAH. Considering the sources, conditions of PAH formation and oil production process peculiarities, it can be assumed that PAH accumulation in oil occurs due to improper drying of oilseeds. In Ukraine, as part of the implementation of the EU Association Agreement with Ukraine, the work is in progress to harmonize national legislation on PAH regulation with European documents. Conclusions. Given the high hygienic importance of polycyclic aromatic hydrocarbons as common carcinogenic foodstuff contaminants, it is necessary to assess health risk factors associated with above-mentioned compounds content in foodstuffs. Special measures to reduce their level in diets for the population should be developed and implemented. Key Words: polycyclic aromatic hydrocarbons, benzo[a]pyrene, safety, risks, harmonization.
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Pich Mitjana, Josep, e David Martínez Fiol. "Manuel Brabo Portillo. Policía, espía y pistolero (1876-1919)". Vínculos de Historia. Revista del Departamento de Historia de la Universidad de Castilla-La Mancha, n.º 8 (20 de junho de 2019): 387. http://dx.doi.org/10.18239/vdh_2019.08.20.
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RESUMEN:El objetivo del artículo es aproximarnos a la controvertida biografía del comisario Manuel Brabo Portillo. El trabajo está basado en fuentes primarias y secundarias. El método utilizado es empírico. En el imaginario del mundo sindicalista revolucionario, Brabo Portillo era el policía más odiado, la reencarnación de la cara más turbia del Estado. Fue, así mismo, un espía alemán relacionado con el hundimiento de barcos españoles, el asesinato del empresario e ingeniero Barret y el primer jefe de los terroristas vinculados a la patronal barcelonesa. La conflictividad que afectó a España en el período de la Primera Guerra Mundial es fundamental para entender los orígenes del terrorismo vinculado al pistolerismo, que marcó la historia político social española del primer tercio del siglo XX.PALABRAS CLAVE: Brabo Portillo, pistolerismo, espionaje, sindicalismo, Primera Guerra Mundial.ABSTRACT:The objective of the article is an approach to the controversial biography of Police Chief Manuel Brabo Portillo. The work is based on primary and secondary sources. The method used is empirical. In the imagery of the revolutionary syndicalist world, Brabo Portillo was the most hated policeman, the reincarnation of the murkiest face of the state. He was also a German spy connected with the sinking of Spanish ships, the murder of businessman and engineer Josep Barret and the first head of the terrorists linked to Barcelona employers. The conflict that affected Spain during the period of the First World War is fundamental in order to understand the origins of terrorism linked to pistolerismo, which marked Spanish social political history during the first third of the twentieth century.KEY WORDS: Brabo Portillo, pistolerismo, espionage, syndicalism, First World War. BIBLIOGRAFÍAAisa, M., La efervescencia social de los años 20. Barcelona 1917-1923, Barcelona, Descontrol, 2016.Aguirre de Cárcer, N., La neutralidad de España durante la Primera Guerra Mundial (1914-1918). I. Bélgica, Madrid, Ministerio de Asuntos Exteriores, 1995.Alonso, G., “’Afectos caprichosos’: Tradicionalismo y germanofilia en España durante la Gran Guerra”, Hispania Nova, 15, 2017, pp. 394-415.Amador, A., El Terror blanco en Barcelona. Las bombas y los atentados personales. Actuación infernal de una banda de asesinos al servicio de la burguesía. El asesinato como una industria, Tarragona, Talleres gráf. Gutenberg, [1920?].Anglés, C., “Contra los sindicatos. Los procesos de la organización obrera. La impostura nunca ha sido justicia”, Solidaridad Obrera, 836 (1/8/1918), p. 1.Balcells, A., El Pistolerisme. Barcelona (1917-1923), Barcelona, Pòrtic, 2009.Ben-Ami, S., La Dictadura de Primo de Rivera (1923-1930), Barcelona, Planeta, 1984.Bengoechea, S., Organització patronal i conflictivitat social a Catalunya. Tradició i corporativisme entre finals de segle i la dictadura de Primo de Rivera, Barcelona, PAM, 1994.Bengoechea, S., El locaut de Barcelona (1919-1920), Barcelona, Curial, 1998.Bengoechea, S., “1919: La Barcelona colpista. 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Edición, Barcelona, Icaria, 1977.Calle Velasco, M. D. de la, “Sobre los orígenes del estado social en España”, Ayer, 25 (1997), pp. 127-150.D’Ors, E., “La unidad de Europa”, La Vanguardia, (1/12/1914), p. 7.Díaz Plaja, F., Francófilos y germanófilos. Los españoles en la guerra europea, Barcelona, Dopesa, 1973.Díez, P., Memorias de un anarcosindicalista de acción, Barcelona, Bellaterra, 2006.Domingo Méndez, R., “La Gran Guerra y la neutralidad española: entre la tradición historiográfica y las nuevas líneas de investigación”, Spagna Contemporanea, 34 (2008), pp. 27-44.Esculies, J., “España y la Gran Guerra. Nuevas aportaciones historiográficas”, Historia y Política, 32 (2014), pp. 47-70.Esdaile, Ch. J., La Quiebra del liberalismo, 1808-1939, Barcelona, Crítica, 2001.Foix, P., Los Archivos del terrorismo blanco. El fichero Lasarte (1910-1930), Madrid, Las Ediciones de la Piqueta, 1978.Forcadell, C., Parlamentarismo y bolchevización. El movimiento obrero español, 1914-1918, Barcelona, Crítica, 1978.Fuentes Codera, M., “El somni del retorn a l’Imperi: Eugeni d’Ors davant la Gran Guerra”, Recerques, 55 (2007), pp. 73-93.Fuentes Codera, M., “Germanófilos y neutralistas. Proyectos tradicionalistas y regeneracionistas para España (1914-1918)”, Ayer, 91/3 (2013), pp. 63-92.Fuentes Codera, M., España en la Primera Guerra Mundial. Una movilización cultural, Madrid, Akal, 2014.García Oliver, J., El Eco de los pasos, Paris/Barcelona, Ruedo Ibérico, 1978.García Sanz, F., España en la Gran Guerra, Madrid, Galaxia Gutenberg, 2014.Giráldez, E., “Brabo Portillo ¡Yo te acuso, Asesino!”, Solidaridad Obrera, 840 (5/8/1918), p. 1.Golden, L., “Les dones com avantguarda; El rebombori del pa del gener 1918”, L’Avenç (1981), pp. 45-52.Golden, L., “The women in command. The Barcelona women’s consumer war of 1918”, UCLA Historical Journal (1985), pp. 5-32.E. González Calleja y F. del Rey Reguillo, La Defensa armada contra la revolución. Una historia de las guardias cívicas en la España del siglo XX, Madrid, CSIC, 1995.González Calleja, E., La Razón de la fuerza. Orden público, subversión y violencia política en la España de la Restauración, 1875-1917, Madrid, CSIC, 1998.González Calleja, E., El Máuser y el sufragio. Orden público, subversión y violencia política en la crisis de la Restauración (1917-1931), Madrid, CSIC, 1999.González Calleja, E., (ed.), Políticas del miedo. Un balance del terrorismo en Europa, Madrid, Biblioteca Nueva, 2002.González Calleja, E., La España de Primo de Rivera. La modernización autoritaria 1923-1930, Madrid, Alianza Editorial, 2005.González Calleja, E., El laboratorio del miedo. Una historia general del terrorismo, Barcelona, Crítica, 2013.González Calleja, E. y Aubert, P., Nidos de espías. España, Francia y la Primera Guerra Mundial, Madrid, Alianza, 2014.González Calleja, E. (coord.), Anatomía de una crisis. 1917 y los españoles, Madrid, Alianza, 2017.Granados de Siles, J., “El escandaloso espionaje de Barcelona”, Solidaridad Obrera, 793 (19/6/1918), p. 1.Gual Villalbí, P., Memorias de un industrial de nuestro tiempo, Barcelona, Sociedad General de Publicaciones, [193?].León-Ignacio, J., Los años del pistolerismo. Ensayo para una guerra civil, Barcelona, Planeta, 1981.León-Ignacio, J., “Brabo Portillo, comisario y político”, Historia y vida, 181 (1983), pp. 68-73.Llates, R., 30 anys de vida catalana, Barcelona, Aedos, 1969.Madrid, F., Ocho meses y un día en el Gobierno Civil de Barcelona (confesiones y testimonios), Barcelona-Madrid, Las ediciones de la flecha, 1932.Manent, J., Records d’un sindicalista llibertari català, 1916-1943, París, Edicions Catalanes de París, 1976.Marquès, J., Història de l’organització sindical tèxtil “El Radium”, Barcelona, La Llar del Llibre, 1989.Márquez, B. y Capo, J. M., Las Juntas militares de defensa, Barcelona, Librería Sintes, 1923.Martínez Fiol, D., El catalanisme i la Gran Guerra (1914-1918). Antologia, Barcelona, La Magrana, 1988.Martínez Fiol, D. y Esculies Serrat, J., L’Assemblea de Parlamentaris de 1917 i la Catalunya rebel, Barcelona, Generalitat de Catalunya, 2017.Martínez Fiol, D. y Esculies Serrat, J., 1917. El año en que España pudo cambiar, Sevilla, Renacimiento, 2018.M.C.C., “El ‘affaire’ Brabo Portillo”, publicado en El Parlamentario y reproducido por Solidaridad Obrera, 926 (2/11/1918), p. 1.Mendoza, E., La verdad sobre el caso Savolta, Barcelona, Seix y Barral, 1975.Morales Lezcano, V., El colonialismo hispano-francés en Marruecos (1898-1927), Madrid, Siglo XXI, 1976.Navarra, A., 1914. Aliadófilos y germanófilos en la cultura española, Madrid, Cátedra, 2014.Navarra, A., Aliadòfils i germanòfils a Catalunya durant la Primera Guerra Mundial, Barcelona, Generalitat-CHCC, 2016.Nisk, “¡Inocente Brabo!”, Solidaridad Obrera, 789 (15/6/1918), p, 1.Pestaña, Á.,“A vuela pluma” y “En Libertad”, Solidaridad Obrera, 840-841 (5-6/8/1918), p. 1.Pestaña, Á., Terrorismo en Barcelona. Memorias inéditas, Barcelona, Planeta, [1979].Pradas Baena, M. A., L’anarquisme i les lluites socials a Barcelona 1918-1923. La repressió obrera i la violència, Barcelona, PAM, 2003.Pujadas, X., Marcel·lí Domingo i el marcel·linisme, [Barcelona], PAM, 1996.Roig, M., Rafael Vidiella. L’aventura de la revolució, Barcelona, Laia, 1976.Romero Salvadó, F. J., “Crisi, agonia i fi de la monarquía liberal (1914-1923)”, Segle XX. Revista catalana d’història, 1 (2008), pp. 57-82.Romero Salvadó, F. J. y Smith, A. (eds.), The Agony of Spanish Liberalism. FromRevolution to Dictatorship 1913-23, Houndmills, Basingstoke, Palgrave Macmillan, 2010.Rosenbusch, A., “Los servicios de información alemanes: sabotaje y actividad secreta”, Andalucía en la historia, 45 (2014), pp. 24-29.Rosenbusch, A., “Guerra Total en territorio neutral: Actividades alemanas en España durante la Primera Guerra Mundial”, Hispania Nova, 15 (2017), pp. 350-372.S. A., “Historia de un ‘bravo’ muy pillo”, La Campana de Gracia, 2569 (28/6/1918), p. 4.S.A., L’Esquella de la Torratxa, (12/7 y 30/8/ y 12/9/1918), pp. 447, 451, 456, 458, 568, 577 y 592.S. A., “A cada puerco le llega su San Martín” y “La muerte de Batet”, Solidaridad Obrera, 711 y 712 (9 y 10/1/1918), p. 1.S. A., Solidaridad Obrera, 713-716 (11-14/1/1918), p. 1.S. 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A., Solidaridad Obrera, (3/7 y 12/12/1918), p. 2.S.A., “Veredicto popular”, Solidaridad Obrera, 790, 791, 793, 794, 795, 798, 799, 800, 802, 808, 809, 810, 811, 815, 816, 817, 818, 819, 820, 821, 822, 823, 825, 826, 827, 828, 829, 830, 832, 833, 834, 835, 836, 837, 838, 839 (16, 17, 19, 20, 21, 24, 25, 26, 28/6; 4, 5, 6, 7, 11, 12, 13, 14, 15, 16, 17, 18, 19, 21, 22, 23, 24, 25, 26, 28, 29, 30, 31/7; 1, 2, 3, 4/8/1918), pp. 1-3.S.A., “Envío a doña Remedios Montero de Brabo Portillo”, 871 (7/9/1918), p. 1.S.A., Solidaridad Obrera, (24, 25, 26, 27, 28 y 30/6 y 3, 6, 8, 5, 10, 12, 13 y 19/7, 4, 5, 9, 23, 24 y 26/8, 21, 24, 25, 31/10, 1, 2/11/ y 1-6, 8, 10, 11, 12, 14, 15, 20, 30 y 31/12/1918), pp. 1-4.Safont, J., Per França i Anglaterra. La I Guerra Mundial dels aliadòfils catalans, Barcelona, Acontravent, 2012.Sánchez Marín, A. L., “El Instituto de Reformas Sociales: origen, evolución y funcionamiento”, Revista Crítica de Historia de las Relaciones Laborales y de la Política Social, 8 (mayo 2014), pp. 7-28.Smith, A., “The Catalan Counter-revolutionary Coalition and the Primo de Rivera Coup, 1917–23”, European History Quaterly 37:1 (2007), pp. 7-34.Smith, A., Anarchism, revolution and reaction. Catalan labor and the crisis of the Spanish State, 1898-1923, New York, Oxford, Berghahn, 2007.Soldevilla, F., El Año político 1920, Madrid, I. de Julio Cosano, 1921.Taibo II, P. I., Que sean fuego las estrellas. Barcelona (1917-1923), Barcelona, Crítica, 2016.Tamames, R. y Casals, X., Miguel Primo de Rivera, Barcelona, Ediciones B, 2004.Tusell, J., Radiografía de un golpe de estado. El ascenso al poder del general Primo de Rivera, Madrid, Alianza, 1987.Val, R. del y Río del Val, J. del, Solidaridad Obrera, 787-788, 790, 794, 801, 805, 807, 811, 814, 818, 828, 829, 836, 970 (13, 14, 16, 20 y 27/6/, 3, 7, 10, 14, 23, 24 y 31/7/ y 1/8/ y 10/121918), p. 1.Vandellós, P., “Contra los sindicatos. Los procesos de la sindicación obrera. De actualidad”, Solidaridad Obrera, 791 (17/6/1918), p. 1.Vidiella, R., Los de ayer. Novela, Madrid-Barcelona, Nuestro Pueblo, 1938.Winston, C. M., La Clase trabajadora y la derecha en España (1900-1936), Madrid, Cátedra, 1989.Winston, C. M., “Carlist workers groups in Catalonia, 1900-1923”, en S. G. Payne (dir.), Identidad y nacionalismo en la España contemporánea: el carlismo, 1833-1975, Madrid, Actas, 1996, pp. 85-101.Wosky, Solidaridad Obrera, 791, 801 y 820, (17 y 21/6/ 10/7/1918), pp. 1 y 3.
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Huibers, Anne, Djurre de Waard, Richard Bulbulia, Gert Jan de Borst e Alison Halliday. "Clinical Experience amongst Surgeons in the Asymptomatic Carotid Surgery Trial-1". Cerebrovascular Diseases 42, n.º 5-6 (2016): 339–45. http://dx.doi.org/10.1159/000446079.
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Introduction: Hospital volume may influence the outcomes of carotid revascularization, but in trials the effect of the clinical experience of individual surgeons on procedural outcome is less certain. We assessed perioperative event rates amongst centers with different trial entry volumes and also the effects of individual operator experience in the first Asymptomatic Carotid Surgery Trial-1 (ACST-1). Methods: In 126 centers participating in ACST-1, surgeons were classified according to their in-trial experience (group A: 50 cases; group B: 51-100 cases; group C: >100 cases), center enrolment volume (group I: <30 patients; group II: 30-75 patients; group III: >75 patients) and center annual hospital volume (group 1: <40 carotid endarterectomies (CEAs); group 2: 40-75 CEAs; group 3: >75 cases). Differences in perioperative event rates were compared using logistic regression analysis. Results: In centers with the most clinical experience compared with those with least experience (groups C vs. A), the number of strokes or deaths was 8 of 275 (2.9%) versus 24 of 810 (3.0%) with OR 0.99 (95% CI 0.44-2.25, p = 0.986). Numbers of strokes or death in high enrolment centers compared with those in low enrolment centers (groups III vs. I) was 20 of 680 (2.9%) versus 21 of 580 (3.6%) with OR 0.81 (95% CI 0.43-1.51, p = 0.921). In centers with a high annual volume compared with those of low annual volume (groups 3 vs. 1), numbers of strokes and death were non-significantly lower, 26 of 823 (3.2%) versus 19 of 422 (4.5%) with OR 0.68 (95% CI 0.37-1.26, p = 0.386). Cumulative stroke risk at 5 and 10 years were similar among different levels of reported clinical experience, enrolment volume and annual hospital volume. Conclusion: Although our data did not demonstrate an association between perioperative complications and operators' experience, enrolment volume or annual hospital volume, rates of stroke or death were numerically lower in both high enrolment and high annual volume centers. This lack of association could be explained by an overall low procedural risk in ACST-1.
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Singh, Devraj, Giridhar Mishra, Raj Kumar e Raja Ram Yadav. "Temperature Dependence of Elastic and Ultrasonic Properties of Sodium Borohydride". Communications in Physics 27, n.º 2 (24 de agosto de 2017): 151. http://dx.doi.org/10.15625/0868-3166/27/2/9615.
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We present the temperature dependent elastic and ultrasonic properties of sodium borohydride. The second and third order elastic constants of NaBH4 have been computed in the temperature range 0-300K using Coulomb and Born-Mayer potential. The sodium borohydride crystallizes into NaCl-type structure. The computed values of second order elastic constants have been applied to evaluate the temperature dependent mechanical properties such as bulk modulus, shear modulus, tetragonal modulus, Poisson’s ratio and Zener anisotropy factor and ultrasonic velocity to predict futuristic information about sodium borohydride. The fracture to toughness ratio (bulk modulus/shear modulus) in sodium borohydride varied from 1.91 to 1.62, which shows its behavioral change from ductile to brittle on increasing the temperature. Then, ultrasonic Grüneisen parameters have been computed with the use of elastic constants in the temperature regime 100-300K. The obtained results have been discussed in correlation with available experimental and theoretical results. [1] A. Amudhavalli, M. Manikandan, A. Jemmy Cinthia, R. Rajeswarapalanichamy and K. Iyakutti, Z. Naturforsch. A 72 (2017) 321. [2] D.Singh, P.K.Yadawa and S.K.Sahu, Cryogenics 50 (2010) 476. [3] V. Bhalla, D.Singh and S.K.Jain, Int. J. Comput. Mat. Sc. Eng. 5 (2016) 1650012. [4] S. Kaushik, D. Singh and G. Mishra, Asian J. Chem. 24 (2012) 5655. [5] D. Chernyshov, A. Bosak, V. Dmitriev, Y. Filmchuk and H. Hagemann, Phys. Rev. B 78 (2008)172104. [6] H. Hagemann, S. Gomes, G. Renaudin and K. Yvon, J. Alloys Compd. 363 (2004) 126. [7] Y. Filinchuk, D. Chernyshov and V. Dmitriev, Z. Kristallogr. 223 (2008) 649. [8] Z.Xiao Dong, J.Z. Yi, Z. Bo, H. Z. Feng and H.Y. Qing, Chin. Phys. Lett. 28(2011)076201. [9] T. Ghellab, Z. Charifi, H. Baaziz, Ş. Uğur, G. Uğur and F. Soyalp, Phys. Scr. 91 (2016) 045804. [10] S. Bae, S. Gim, H. Kim and K. Hanna, Appl. Catal. B: Environm. 182 (2016) 541. [11] G. Renaudin, S. Gomes, H. Hagemann, L. Keller and K. Yvon, J Alloys Compd. 375 (2004) 98. [12] P. Vajeeston, P. Ravindran, A. Kjekshus and H. Fjellvåg, J Alloys Compd. 387 (2005) 97. [13] S. Orimo, Y. Nakamori, J.R. Eliseo, A. Zuttel and C. M. Jensen, Chem. Rev. 107 (2007) 4111. [14] A. Istek and E. Gonteki, J. Environ. Bio.7 (2009) 951. [15] R. S. Kumar and A.L. Cornelinus, Appl. Phys. Lett. 87 (2005) 261916. [16] E. Kim, R. Kumar, P. F. Weck, A. L. Cornelius, M. Nicol, S. C. Vogel, J. Zhang, M. Hartl, A.C. Stowe, L. Daemen and Y. Zhao, J. Phys. Chem. Lett. B 111 (2007) 13873. [17] K. Brugger, Phys. Rev. 133 (1964) A1611. [18] P.B. Ghate, Phy. Rev. 139 (1965) A1666 [19] S. Mori, Y. Hiki, J. Phys. Soc. Jpn. 45 (1975) 1449. [20] V. Bhalla, R. Kumar, C. Tripathy and D. Singh, Int. J. Mod. Phys. B 27 (2013) 1350116. [21] D. Singh, S. Kaushik, S. Tripathi, V. Bhalla and A. K. Gupta, Arab. J. Sci. Eng. 39 (2014) 485. [22] K. Brugger, Phys. Rev.137 (1965) 1826. [23] W. P. Mason, Physical Acoustics, vol. IIIB, Academic Press, New York, 1965. [24] M.P. Tosi, Solid State Physics, vol. 12, Academic Press, New York, 1965. [25] Y. Nakamori and S. Orimo, J. Alloy Compd.370(2004)271. [26] D. Singh, D.K. Pandey and P.K. Yadawa, Cent. Eur. J. Phys. 7 (2009) 198. [27] V. Bhalla, D. Singh, G. Mishra and M. Wan, J. Pure Appl. Ultrason. 38 (2016)23. [28] D. Singh, S. Kaushik, S.K. Pandey, G. Mishra and V. Bhalla, VNU J. Sc.: Math. Phys. 32(2016)43. [29] J.P.Watt and L. Peselnick, J.Appl. Phys. 51 (1980) 1525. [30] S.F.Pugh, Philos.Mag. 45 (1954) 823. [31] V. Bhalla, D. Singh and S.K. Jain, Int. J. Thermophys. 37(2016)33. [32] V. Bhalla, D. Singh, S.K. Jain and R. Kumar, Pramana- J. Phys. 86 (2016)135.
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Josipovic, Marko, Hrvoje Plavsic, Vlado Kovacevic, Monika Markovic e Dario Iljkic. "Impacts of irrigation and genotype on yield, protein, starch and oil contents in grain of maize inbred lines". Genetika 46, n.º 1 (2014): 243–53. http://dx.doi.org/10.2298/gensr1401243j.
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Four inbred lines of maize (Os 438-95 = C1, Os 30-8 = C2, Os 6 = C3 and Os 1-44 =C4) were grown for 4-year period (2006-2009) in the stationary field experiment on Osijek eutric cambisol. Impact of irrigation, nitrogen fertilization and genotype were tested. Soil moisture was maintained by two irrigation rates from 60-100% and 80-100% of the field water capacity). Two steps of N (0, 100 and 200 kg N ha-1) were applied, while P and K fertilization was equal (500 kg/ha NPK 0:30:20). Eight maize genotypes (four inbred lines and four hybrids) were grown on each basic plot of fertilization. The experiment was duplicated for maize - soybean rotation. The experiment was set by split-split plot method according to randomized block design in three replicates. The basic plot areas were 617.2 m2 (irrigation), 313.6 m2 (fertilization) and 39.2 m2 (genotype). Selection of N non-fertilized treatment and four inbred lines were made for this study with aim of testing year (A) irrigation (B) and genotype (C) effects under natural N-soil conditions. Average grain yield in level 1809 kg ha-1without N fertilization is indication of very high fertility of the soil. Differences of yield among the years were from 823 (2007) to 2450 (2006) kg ha-1. Excessive drought and high air-temperature stress is responsible for the low maize yield in 2007. Irrigation considerable affected on maize yields (4-year averages: 1500, 1809 and 2118 kg ha-1, for B1, B2 and B3, respectively). Differences of the 4-year average yields among the genotypes were from 1259 (C3) to 2765 (C1) kg ha-1. Differences of yield among the genotypes in the different years were also considerable because the lowest yield was for 71% (A1), 23% (A2), 63% (A3) and 40% (A4) lower in comparison to the highest yield. The genotype effects under different water supplies were less influencing factor because the high-yielding C1 had for 128%, 129% and 106% the higher yield compared to the low-yielding C3, for B1, B2 and B3, respectively. Differences of grain -protein, -starch and -oil among the years was from 9.61 to 11.84%, from 68.51% to 70.93% and from 3.50% to 4.17%, respectively. The C2 separated by the higher grain protein contents (10.93%) from the remaining three genotypes (average 9.96%). The genotype effects on starch and oil contents were from 69.83% (C4) to 70.58% (C1) and from 3.56% (C3) to 4.09% (C1), respectively.
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Marshall, A. "Basic and Applied Aspects of Seed Biology: Proceedings of the Fifth International Workshop on Seeds, Reading 1995. Ed. by R. H. ELLIS, M. BLACK, A. J. MURDOCH and T. D. HONG. 24x16 cm. Pp. 823. Dordrecht, The Netherlands: Kluwer Academic Publishers, 1996. Price h/b: f286.00, ISBN 0 7923 4363 8. Seeds Handbook: Biology, Production, Processing and Storage. By B. B. DESAI, P. M. KOTECHA and D. K. SALUNKHE. 25x18 cm. Pp. 627. New York: Marcel Dekker Inc., 1997. Price h/b: $185.00, ISBN 0 8247 0042 2." New Phytologist 138, n.º 4 (abril de 1998): 743–50. http://dx.doi.org/10.1046/j.1469-8137.1998.00149-1.x.
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Mansoor, Wafaa, Graeme Hocking e Duncan Farrow. "Modelling of hydrogen diffusion in the retina". ANZIAM Journal 61 (7 de julho de 2020): C119—C136. http://dx.doi.org/10.21914/anziamj.v61i0.14995.
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A simple mathematical model for diffusion of hydrogen within the retina has been developed. The model consists of three, well-mixed, one dimensional layers that exchange hydrogen via a diffusion process. A Fourier series method is applied to compute the hydrogen concentration. The effect of important parameters is examined and discussed. The results may contribute to an understanding of the hydrogen clearance technique to estimate blood flow. A two dimensional numerical method for the hydrogen diffusion is also presented. It is shown that the predominant features of the process are captured quite well by the simpler model. References V. A. Alder, D. Y. Yu, S. J. Cringle and E. N. Su. Experimental approaches to diabetic retinopathy. Asia-Pac. J. Ophthalmol. 4:20–25, 1992. J. C. Arciero, P. Causin and F. Malgoroli. Mathematical methods for modeling the microcirculation. AIMS Biophys. 4:362–399, 2017. doi:10.3934/biophy.2017.3.362 D. E. Farrow, G. C. Hocking, S. J. Cringle and D.-Y. Yu. Modeling Hydrogen clearance from the retina. ANZIAM J. 59:281–292, 2018. doi:10.1017/S1446181117000426 A. B. Friedland. A mathematical model of transmural transport of oxygen to the retina. Bull. Math. Biol. 40:823–837, 2018; doi:10.1007/BF02460609 D. Goldman. Theoretical models of microvascular oxygen transport to tissue. Microcirculation 15:795–811, 2008. doi:10.1080/10739680801938289 A. C. Hindmarsh. ODEPACK, A Systematized Collection of ODE Solvers. In Scientific Computing, R. S. Stepleman, et al., Eds., pp. 55-64. North-Holland, Amsterdam, 1983. S. S. Kety. The theory and applications of the exchange of inert gas at the lungs and tissues. Pharmacol. Rev. 3:1–41, 1951. http://pharmrev.aspetjournals.org/content/3/1/1 B. P. Leonard. A stable and accurate convective modelling procedure based on quadratic upstream interpolation. Comput. Methods Appl. Mech. Eng. 19:59–98, 1979. doi:10.1016/0045-7825(79) 90034-3 S. L. Mitchell. Coupling transport and chemistry: numerics, analysis and applications. PhD thesis, University of Bath, UK, 2003. https://researchportal.bath.ac.uk/en/studentTheses/coupling-transport-and-chemistry-numerics-analysis-and-applicatio G. A. Winchell. Mathematical model of inert gas washout from the retina: evaluation of hydrogen washout as a means of determining retinal blood flow in the cat. Master\textquoteright s Thesis, Northwestern University, Evanston, USA, 1983. https://search.library.northwestern.edu/permalink/f/5c25nc/01NWU_ALMA21563278530002441 D. Y. Yu, V. A. Alder and S. J. Cringle. Measurement of blood flow in rat eyes by hydrogen clearance. Am. J. Physiol. (Heart Circ. Physiol.) 261:H960–H968, 1991. doi:10.1152/ajpheart.1991.261.3.H960 D. Y. Yu, S. J. Cringle, V. A. Alder, E. N. Su, and P. K. Yu, Intraretinal oxygen distribution and choroidal regulation in the avascular retina of guinea pigs. Am. J. Physiol. (Heart Circ. Physiol.) 270:H965-H973, 1996. doi:10.1152/ajpheart.1996.270.3.H965 S. Cringle, D.-Y. Yu, V. Alder, E.-N. Su, and P. Yu. Choroidal regulation of oxygen supply to the guinea pig retina. In A. G. Hudetz, and D. F. Bruley (Eds.), Oxygen Transport to Tissue XX, pp. 385–389. Springer, 1998. doi:10.1007/978-1-4615-4863-8
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Matoba, S., T. Somfai, T. Nagai e M. Geshi. "237 THE EFFECTS OF BULLS AND X-SORTING OF SPERM ON THE ACCURACY OF NONINVASIVE CRITERIA TO PREDICT BLASTOCYST FORMATION OF IN VITRO-PRODUCED BOVINE EMBRYOS". Reproduction, Fertility and Development 27, n.º 1 (2015): 208. http://dx.doi.org/10.1071/rdv27n1ab237.
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Previously, an early first cleavage and a second cleavage after IVF with a normal cleavage pattern defined by even blastomeres without fragments or protrusions was found to be a potent marker for the selection of embryos with high developmental competence (Sugimura et al. 2012 PLoS ONE 7, e36627). The aim of this study was to investigate the effects of bulls and X-sorting of sperm on the ability of these simple noninvasive markers to predict the potency of bovine IVF embryos to develop to the blastocyst stage in vitro. Immature oocytes were matured in TCM199 supplemented with 0.02 armour unit mL–1 FSH and 5% calf serum at 38.5°C in 5% CO2 and 95% air for 22 to 23 h. After maturation, oocytes were inseminated with either of non-sorted frozen-thawed sperm from 3 bulls (A–C) or X-sorted sperm of bull A. Putative zygotes were cultured (IVC) in CR1aa medium supplemented with 5% calf serum and 0.25 mg mL–1 linoleic acid albumin at 38.5°C in 5% CO2, 5% O2, and 90% N2 for 216 h. Embryo kinetics were observed individually by time-lapse cinematography (CCM-1.3Z; Astec, Fukuoka, Japan; Sugimura et al. 2010 Biol. Reprod. 83, 970–978). First and second cleavage kinetics and pattern were categorized according to Sugimura et al. (2012). For each bull, blastocyst development from embryos possessing the following 3 selection markers was compared: (marker 1) the first cleavage within 28 h after IVF, (marker 2) marker 1 combined with 2 even blastomeres without fragments or protrusions, and (marker 3) marker 2 combined with the second cleavage within 50 h after IVF with ≥6 even blastomeres without fragments or protrusions, respectively. Data were analysed by the Yates' corrected chi-square test. A total of 823 oocytes were used in at least 3 replications. When non-sorted sperm was used for IVF, there was not difference (P > 0.05) in total blastocyst formation rates on Day 8 (Day 0 = IVF) among bulls (ranging between 49.5 and 60.8%); however, blastocyst formation rate of embryos generated from X-sorted sperm of bull A (39.5%) was lower (P < 0.05) compared with other groups despite of similar cleavage rates. Embryos having marker 3 criteria developed to the blastocysts stage at significantly higher rates than those having marker 1 criteria in case of non-sorted sperm of bulls A, B, C, and X-sorted sperm of bull A (75.9, 87.0, 90.0, and 75.0% v. 59.5, 62.2, 63.6, and 46.3%, respectively). In groups produced from non-sorted sperm of bulls A, B, C, and X-sorted sperm of bull A, blastocyst development rates of embryos with marker 2 criteria (73.7, 75.0, 90.0, and 65.8%, respectively) were higher (P < 0.05) than those of embryos having marker 1 criteria but did not differ significantly from those with marker 3 criteria. Our results reveal that a first cleavage within 28 h after IVF to 2 even blastomeres without fragments or protrusions are potent predictive markers of the developmental competence of bovine embryos to the blastocyst stage regardless of bulls and sperm sorting.Research was partly supported by JSPS KAKENHI (26450388).
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Graziadei, Giovanna, Alessia Marcon, Martina Soldarini, Ilaria Gandolfi, Luisa Ronzoni, Marianna Giuditta, Pietro Ridolfi e Maria Domenica Cappellini. "Clinical Complications in Adult Patients with Sickle Cell Anemia and β-Thalassemia-Sickle Cell Disease". Blood 120, n.º 21 (16 de novembro de 2012): 4767. http://dx.doi.org/10.1182/blood.v120.21.4767.4767.
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Abstract Abstract 4767 Background. Sickle-Cell Disease (SCD) is one of the most common severe monogenic inherited disorders worldwide, due to hemoglobin S (HbS), with reduced affinity for the oxygen. HbS polymerization, leading to erythrocyte rigidity, vaso-occlusion and hemolytic anemia, is central in the pathophysiology and crucial for the clinical outcome. The term SCD refers to Sickle Cell Anemia (SCA) due to homozygosis for βS allele, HbS/β-thalassemia (T-SCD) due to compound of β-thal and βS allele, and HbSC disease, owing to the coinheritance of βS and βcalleles. SCD is a multiorgan disease characterized by recurrent acute events and progressive organ damage, worsening during the life. Aims. This is a retrospective monocentric study aimed to assess and compare the clinical complications among 59 adult SCD patients, followed at the Hereditary Anemia Centre of the Foundation IRCCS “Ca Granda” Ospedale Maggiore Policlinico, in Milan, Italy. Methods. Mutation analysis of the b globin gene was established by direct DNA sequencing on the ABI Prism 310 genetic analyzer. Clinical and hematological features were evaluated by routine tests and physical examination, with special attention to the erythropoiesis stress parameters as LDH values and extramedullary erythropoietic (EE) masses. Results. Fifty-nine adult SCD patients, 16 SCA and 43 T-SCD, were evaluated. In T-SCD patients detected b-mutations were severe (b°) in 69.8%, and moderate or mild (b+-b++) in 30.2%. The mean age of SCA patients was 36±9 and 41±11 years for T-SCD patients. For both groups the mean follow-up was 20±6 years, while the mean age at the presentation in our Centre was 32±8 years in SCA patients and 31±10 years in T-SCD ones. Five out of 16 (31.2%) SCA patients and 16/43 (37.2%) T-SCD patients were male. HbF mean levels were 6.9±5.1% and 10.1±7.2%, respectively in SCA and T-SCD group; surprisingly Hb mean levels were lower in SCA (9.3±1.3 g/dl) than in T-SCD (9.9±1.4 g/dl) patients. Comparing SCA and T-SCD, there was statistically significant difference in splenic features: splenectomy was performed in 2/16 (12.5%) SCA patients vs 21/43 (48.8%) T-SCD patients (p-value < 0.01). Splenomegaly was absent in SCA, while was detected in 11/22 (50%) T-SCD (p-value < 0.0001); all SCA patients had functional asplenia, not observed in T-SCD patients; splenic infarctions were absent in SCA patients and were detected in 7/22 (31.8%) T-SCD patients, of whom 5 had splenomegaly and 2 had normal spleen size (pvalue <0.001). On the other side, there was not statistically significant difference in the prevalence of stroke, acute chest syndrome (ACS), bone pain crisis, sepsis, leg ulcers and priapism. However, we observed some clinical differences, even if not statistically significant. Cholecistectomy was performed in 4/16 (25%) SCA patients vs 17/43 (39.5%) T-SCD patients, and gallstones were detected respectively in 5/12 (41.7%) and in 14/26 (53.8%) of SCA and T-SCD patients. Thrombotic events were absent in SCA patients, compared to 4/43 (9.3%) T-SCD patients. Furthermore, we detected EE in 3/16 (18.6%) SCA and in 3/43 (7%) T-SCD, all carrying b° thal mutations. We underlie that Hb levels and LDH values were higher in SCA than in T-SCD patients (823±295 vs 689±209 U/L). About the treatment, 14/16 (87.5%) SCA and 31/43 (72%) T-SCD underwent to top-up transfusion; 5/43 (11.6%) T-SCD were regularly transfused. Seven out of 16 (43.8%) SCA and 18/43 (41.8%) T-SCD patients were treated with Hydroxycarbamide (HU). Criteria for transfusion therapy were: painful crisis not responsive to HU, major clinical complications, such as stroke or ACS, extramedullary erythropoietic masses associated with high LDH levels and low Hb values. Conclusions. These data suggest that SCA and T-SCD patients have similar clinical course. Splenomegaly is present only in T-SCD patients, probably due to the increased amount of extravascular hemolysis. Surprisingly, SCA patients showed EE and lower Hb levels with higher LDH values compared to T-SCD ones. This could be related to the prevalence of intravascular hemolysis, that can lead to erythropoietic stress in SCA, even if tissues are better oxygenated in these patients because of biochemical characteristic of HbS in terms of decreased oxygen affinity. These observations could be important to evaluate transfusion and HU treatment. Disclosures: Cappellini: Novartis: Research Funding.
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Ma, Xiao, Xiaoyi Li, Danyue Peng, Huifang Wang, Lei Li, Hao Zhou, Daohong Zhou, Yi Luo e Lingbo Liu. "Inhibition of Both Activated p38 Mapkα and mTORC1 Potentiates the Effect of SR1 on Promoting Hematopoietic Reconstitution of Ex Vivo Expanded Human Umbilical Cord Blood Hematopoietic Stem Cells". Blood 128, n.º 22 (2 de dezembro de 2016): 2173. http://dx.doi.org/10.1182/blood.v128.22.2173.2173.
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Abstract Hematopoietic stem cells (HSCs) transplantation is a curative treatment for various hematological disorders. However, its use has been limited in part by the difficulty to obtain sufficient numbers of transplantable HSCs, especially from human umbilical cord bloods (hUCBs). Ex vivo expansion of cord blood HSCs can potentially mitigate the shortfall if the expanded HSCs can maintain their stemness for long-term hematopoietic reconstitution. Our previous studies have shown that some hUCB HSCs lose their "stemness" during ex vivo expansion in part due to induction of cellular senescence via p38MAPKα(p38) or mTORC1 activation and inhibition of p38 and mTOR C1 promotes HSCs expansion (Ann Hematol. 2012; 91:813-823; Transplantation. 2014; 97:20-29). Recently, it was shown that StemRegenin 1 (SR1), an antagonist of the aryl hydrocarbon receptor (AHR), could significantly promote ex vivo expansion of HSCs, primarily via inhibition of HSCs differentiation. Therefore, we investigated whether the combination of SR1 with LY2228820 (LY) and rapamycin (Rapa) to inhibit p38 and mTOR C1, respectively, can enhance ex vivo expansion of hUBC HSCs by inhibiting HSCs differentiation and senescence. Next, we confirmed that co-inhibition of activated p38 and mTORC1 promotes SR1 induced HSCs expansion ex vivo through inhibition of senescence.Our combined culture system in 7 days led to a 16.2-fold increase for CD34+CD90+ subpopulation and a 6.1-fold increase for CD34+CD45RA- subpopulation compared to input cells (Blood,126(23):381-381) .To determine the hematopoietic reconstitution ability of the progeny of hUCB CD34+ cells expanded with inhibitors of p38, mTORC1, and AHR, we transplanted 1000 to 30000 uncultured hUCB CD34+ cells or a fraction of the final culture equivalent to 1000 to 10000 starting hUCB CD34+ cells into sub-lethally irradiated 6 to 10-week-old NOD-Prkdcscid Il2rgnull (NOG) mice. Donor cell engraftment was analyzed at 8 and 13 weeks after the transplantation. The results showed that the progeny of 10,000 hUCB CD34+ cells cultured with LY, Rapa and SR1 produced significant greater donor cell engraftment in the recipients' peripheral blood compared with the same number of un-cultured hUCB CD34+ cells (2.19-fold, p<0.01), the progeny of 10,000 hUCB CD34+ cells cultured with vehicle (2.76-fold, p<0.01), or the progeny of 10,000 hUCB CD34+ cells cultured with SR1 alone (1.72-fold, p<0.05). The similar results were also found in the recipients' bone marrow and spleen. In addition, the progeny of 3,000 hUCB CD34+ cells cultured with LY, Rapa and SR1 generated the levels of peripheral blood donor cell engraftment that similar to these produced by 30,000 un-cultured hUCB CD34+ cells and the progeny of 10,000 hUCB CD34+ cells cultured with SR1 alone. More importantly, the hUCB CD34+ cells cultured with LY, Rapa and SR1 retained multi-lineage differentiation potential as they were able to produce human B cells, myeloid cells, red blood cell progenitors, megakaryocytes, and NK cells in the recipients' bone marrow. Furthermore, hUCB CD34+ cells cultured with LY, Rapa and SR1 produced the highest levels of human HSCs (CD34+CD38-/CD34+CD90+/CD34+CD45RA- cells) engraftment compared to all other cells. Collectively, these findings suggest that the combined inhibition of p38, mTORC1 and AHR is more effective in promoting the expansion and hematopoietic reconstitution of hUBC HSCs than inhibition of p38, mTORC1 or ARH alone probably via inhibition of HSCs senescence and differentiation. This new strategy may alleviate the limitation of hUBC for transplantation in adult patients. Disclosures No relevant conflicts of interest to declare.
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Гордиенко, Татьяна Александровна, Раиса Анатольевна Суходольская, Юлия Александровна Лукьянова e Дмитрий Николаевич Вавилов. "ВЛИЯНИЕ НАРУШЕНИЙ ПОЧВЕННОГО ПОКРОВА НА СТРУКТУРНУЮ ОРГАНИЗАЦИЮ ПОЧВЕННОЙ МЕЗОФАУНЫ ПОЙМЕННО-ЛУГОВЫХ СООБЩЕСТВ НАЦИОНАЛЬНОГО ПАРКА «НИЖНЯЯ КАМА»". Российский журнал прикладной экологии, n.º 2 (6 de julho de 2022): 12–19. http://dx.doi.org/10.24852/2411-7374.2022.2.12.19.
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В результате прокладки трубопроводов и установки стоек высоковольтной линии электропередач в границах Елабужских и Танаевских лугов Национального парка «Нижняя Кама» были нарушен растительный и почвенный покровы. В работе проведена оценка сообществ педобионтов нарушенных и контрольных участков лугов. Показано сокращение таксономического состава и обилия мезофауны на трансформированных участках, численность в них педобионтов соответствовала показателям среднего и низкого значения. На контрольных участках обилие и таксономическое разнообразие мезофауны оставалось высоким.
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Гордиенко Т.А., Вавилов Д.Н., Лукьянова Ю.А. Структурная организация сообщества наземных и почвенных беспозвоночных на естественных и нарушенных участках Танаевских лугов Национального парка «Нижняя Кама» // Труды Мордовского государственного природного заповедника имени П.Г. Смидовича. 2021. Вып. 28. С. 38‒50.
Гордиенко Т.А., Вавилов Д.Н., Суходольская Р.А., Лукьянова Ю.А. Влияние антропогенной трансформации луговых экосистем Национального парка «Нижняя Кама» на сообщества наземных и почвенных беспозвоночных // Российский журнал прикладной экологии. 2017. №3. С. 7‒11.
Гордиенко Т.А., Суходольская Р.А., Вавилов Д.Н., Лукьянова Ю.А. Устойчивость луговых сообществ педобионтов при антропогенной нагрузке // Концептуальные и прикладные аспекты научных исследований и образования в области зоологии беспозвоночных / Сборник статей V Междунар. конф. Томск: Изд-во Томского государственного ун-та, 2020. С. 59‒62.
Дорохов К.В., Шелухо В.П., Кистерный Г.А. Сравнительное влияние антропогенных факторов на состав, трофическую структуру и плотность мезофауны // Лесной журнал. 2016. №5. С. 9‒21.
Кадастр сообществ почвообитающих беспозвоночных (мезофауна) естественных экосистем Республики Татарстан. Казань: Изд-во Казанского ун-та, 2014. 308 с.
Методы почвенно-зоологических исследований. М.: Наука, 1975. 280 с.
Bagaria G., Helm A., Rodá F., Pino, J. Assessing coexisting plant extinction debt and colonization credit in a grassland-forest change gradient // Oecologia. 2015. Vol. 179. P. 823‒834. doi:1007/s00442-015-3377-4.
Clavel J., Julliard R., Devictor V., Worldwide decline of specialist species: toward a global functional homogenization? // Frontiers in ecology and the environment. Vol. 94. P. 222–228. doi: 10.1890/080216.
Figueiredo L., Krauss J., Steffan-Dewenter I., Cabral J.S., Understanding extinction debts: spatio-temporal scales, mechanisms and a roadmap for future research // Ecography. 2019. Vol. 42. P. 1973‒1990. doi: 1111/ecog.04740
Krauss J., Bommarco R., Guardiol, M. Habitat fragmentation causes immediate and time delayed biodiversity loss at different trophic levels // Ecology Letters. 2010. Vol. 3. P. 597‒605. doi: 1111/j.1461-0248.2010.01457.x
Kuussaari M., Bommarco R., Heikkinen R.K. Extinction debt: a challenge for biodiversity conservation // Trends in ecology & evolution. Vol. 24. P. 564‒571. doi: 10.1016/ j.tree.2009.04.011
Lӧffler F., Poniatowsk D., Fartmann T. Extinction debt across three taxa in well-connected calcareous grasslands // Biological conservation. 2020. Vol. 246. P. 108588. вoi: 1016/j.biocon.2020.108588
Buisson E., Fidelis A., Overbeck G.E., Schmidt I.B., Durigan G., Young T.P., Alvarado S.T., Arruda A.J., Boisson S., Bond W., Coutinho A., Kirkman K., Oliveira R.S., Schmitt M.H., Siebert F.,Siebert S.J., Thompson D.I., Silveira F.A.O. A research agenda for the restoration of tropical and subtropical grasslands and savannas // Restoration ecology. 2021. Vol. 29. P. e13528. doi: 1111/rec.13292
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Cahu, Xavier, Martin Carre, Christian Recher, Emmanuel Gyan, Jean-Francois Hamel, Arnaud Pigneux, Norbert Vey et al. "Impact of High Body Surface Area on AML Outcome in Younger Patients: A Goelams Study". Blood 124, n.º 21 (6 de dezembro de 2014): 973. http://dx.doi.org/10.1182/blood.v124.21.973.973.
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Abstract In younger patients with acute myeloid leukemia (AML), standard intensive induction chemotherapy combines anthracyclins and cytarabine (Ara-C). While dosage is usually determined according to body-surface area (BSA), various chemotherapy adjustments are empirically performed in patients with high BSA from full dose administration to capping doses. The aim of the present study is to determine the outcome of younger AML patients with high BSA at diagnosis. Between November 2001 and April 2005, the prospective GOELAMS 2001 trial enrolled patients between 18 and 60 affected with non promyelocytic AML.1,2 Briefly, patients randomly received either daunorubicin or idarubicin in association with standard dose Ara-C during induction therapy. Height, weight and induction chemotherapy doses were registered at diagnosis. BSA was evaluated using the formula of Dubois and Dubois. BSA was categorized in low (BSA ≤1.5m2), intermediate (1.5<BSA<2), high (2<BSA<2.15) or very high BSA (BSA ≥2.15). In the course of consolidation therapy, patients with a matched related donor received an allogeneic stem cell transplantation. Patients without a matched related donor received either a single or tandem autologous bone marrow transplantation. Patients who did not achieve sufficient stem cell mobilization received chemotherapy-only consolidation. 823 patients were eligible to induction therapy. 43 (5%), 638 (77%), 91 (11%) and 51 (6%) patients displayed low, intermediate, high or very high BSA at diagnosis, respectively. Median age, performance status, karyotype group were similar in all BSA groups. On the contrary, male gender was enriched in high and very high BSA groups (86% and 88%, respectively). During induction therapy, 20 patients (39%) with very high BSA were administered reduced dose (decrease of > 10% in anthracyclin or Ara-C dosing compared to full dose) versus 8%, 4% and 7% in low, intermediate or high BSA subgroups (p <10-5). Type of consolidation therapy - chemotherapy, autologous or allogeneic stem cell transplantation - was not significantly different in BSA groups. Compared to patients with intermediate BSA, patients with a low or high BSA displayed a similar OS and EFS. On the contrary, patients with a very high BSA displayed a decreased 5-year OS (27% (95% CI, 18-43) vs 47% (95% CI, 44-51), p= 0.006, figure 1A) and LFS (22% (95% CI, 13-36) vs 41% (95% CI, 37-45), p=0.004). Non-relapse mortality was similar in the very high or intermediate BSA groups, suggesting that intensive therapy was similarly tolerated in intermediate or very high BSA patients. Meanwhile, relapse incidence was increased in patients with a very high BSA compared to intermediate BSA patients (61% (95% CI, 46-73) vs 44% (95% CI, 40-48), p = 0.02, figure 1B). Conclusion: patients with a very high BSA display an adverse outcome, due to an increased relapse incidence. Meanwhile, non-relapse mortality is not significantly increased in very high BSA patients. These data suggest that patients with very high BSA should receive full dose induction chemotherapy. Bibliography; 1. Recher C , Bene MC, Lioure B et al. Leukemia, Long-term results of a randomized phase 3 trial comparing idarubicin and daunorubicin in younger patients with acute myeloid leukaemia. Leukemia 2014; 28:440-3. 2. Lioure B, Bene MC, Pigneux A et al. Early matched sibling hematopoietic cell transplantation for adult AML in first remission using an age-adapted strategy: long-term results of a prospective GOELAMS study. Blood 2012; 119: 2943–2948. Figure 1 Figure 1. Disclosures No relevant conflicts of interest to declare.
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Schelling, Philip. "Anmerkung zu OVG Nordrhein-Westfalen, Beschl. v. 3.8.2018 13 B 826/18". Medizinrecht 37, n.º 9 (setembro de 2019): 743–45. http://dx.doi.org/10.1007/s00350-019-5322-8.
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Le Gia, Quoc Thong, Michael Clarke, Josef Dick e David Pye. "Elasticity equations with random domains—the shape derivative approach". ANZIAM Journal 62 (9 de março de 2022): C256—C272. http://dx.doi.org/10.21914/anziamj.v62.16120.
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In this work, we discuss elasticity equations on a two-dimensional domain with random boundaries and we apply these equations to modelling human corneas. References R. C. Augustyn, D. Nankivil, A. Mohamed, B. Maceo, F. Pierre, and J.-M. Parel. Human ocular biometry. Exp. Eye Res. 102 (2012), pp. 70–75. doi: 10.1016/j.exer.2012.06.009. F. Ballarin, A. Manzoni, G. Rozza, and S. Salsa. Shape optimization by free-form deformation: Existence results and numerical solution for Stokes flows. J. Sci. Comput. 60.3 (2014), pp. 537–563. doi: 10.1007/s10915-013-9807-8. S. C. Brenner and L.-Y. Sung. Linear finite element methods for planar linear elasticity. Math. Comp. 59 (1992), pp. 321–338. doi: 10.2307/2153060. M. C. Delfour and J.-P. Zolesio. Shapes and geometries. Advances in Design and Control. SIAM, Philadelphia, 2001. doi: 10.1137/1.9780898719826. J. Dick. Higher order scrambled digital nets achieve the optimal rate of the root mean square error for smooth integrands. Ann. Statist. 39.3 (2011), pp. 1372–1398. doi: 10.1214/11-AOS880. J. Dick, F. Y. Kuo, Q. T. Le Gia, and Ch. Schwab. Multilevel higher order QMC Petrov–Galerkin discretization for affine parametric operator equations. SIAM J. Num. Anal. 4.54 (2015), pp. 2541–2568. doi: 10.1137/16M1078690 A. Eilaghi, J. G. Flanagan, I. Tertinegg, C. A. Simmons, G. W. Brodland, and C. R. Ethier. Biaxial testing of human sclera. J. Biomech. 43 (2010), pp. 1696–1701. doi: 10.1016/j.jbiomech.2010.02.031. U. Fares, A. M Otri, M. A. Al-Aqaba, and H. S. Dua. Correlation of central and peripheral corneal thickness in healthy corneas. Cont. Lens Anterior Eye 35 (2012), pp. 39–45. doi: 10.1016/j.clae.2011.07.004. R. N. Gantner and Ch. Schwab. Computational higher order quasi-Monte Carlo integration. Monte Carlo and quasi-Monte Carlo methods. Vol. 163. Springer Proc. Math. Stat. Springer, 2016, pp. 271–288. doi: 10.1007/978-3-319-33507-0_12. on p. C129). H. Harbrecht. Second moment analysis for Robin boundary value problems on random domains. Singular Phenomena and Scaling in Mathematical Models. Ed. by M. Griebel. Springer, 2014, pp. 361–381. doi: 10.1007/978-3-319-00786-1_16. H. Harbrecht, M. Peters, and M. Siebenmorgen. Analysis of the domain mapping method for elliptic diffusion problems on random domains. Numer. Math. 134.4 (2016), pp. 823–856. doi: 10.1007/s00211-016-0791-4. H. Harbrecht, R. Schneider, and Ch. Schwab. Sparse second moment analysis for elliptic problems in stochastic domains. Numer. Math. 109.3 (2008), pp. 385–414. doi: 10.1007/s00211-008-0147-9. R. Hiptmair and J. Li. Shape derivatives in differential forms I: an intrinsic perspective. Ann. Matematica Pura Appl. 192 (2013), pp. 1077–1098. doi: 10.1007/s10231-012-0259-9. C. R. de Lima, L. A. Mello, R. G. Lima, and E. C. N. Silva. Electrical impedance tomography through constrained sequential linear programming: a topology optimization approach. Meas. Sci. Tech. 18.9 (2007), pp. 2847–2858. doi: 10.1088/0957-0233/18/9/014. M. Loeve. Probability theory I. Graduate Texts in Mathematics. Springer-Verlag, 1978. doi: 10.1007/978-1-4684-9464-8. R. Martin, S. Jonuscheit, A. Rio-Cristobal, and M. J. Doughty. Repeatability of Pentacam peripheral corneal thickness measurements. Cont. Lens Anterior Eye 38 (2015), pp. 424–429. doi: 10.1016/j.clae.2015.05.001. R. von Mises. Mechanik der festen Körper im plastisch-deformablen Zustand. Nachrichten von der Gesellschaft der Wissenschaften zu Göttingen. Mathematisch-Physikalische Klasse 1 (1913), pp. 562–592. url: https://eudml.org/doc/58894 F. Orucoglu and E. Toker. Comparative analysis of anterior segment parameters in normal and keratoconic eyes generated by Scheimpflug tomography. J. Ophthalmol., 925414 (2015), pp. 1–8. doi: 10.1155/2015/925414. D. C. Pye. A clinical method for estimating the modulus of elasticity of the human cornea in vivo. PLOS One 15 (2020), pp. 1–19. doi: 10.1371/journal.pone.0224824.
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Anggraini, Putri Ayu, St Ratnah e Sesilia TR Dewi. "Skrining Fitokimia dan Potensi Antimikroba Herba Kemangi (Ocimum americanum L.) Terhadap Staphylococcus aureus, Salmonella typhi dan Candida albicans". Journal of Experimental and Clinical Pharmacy (JECP) 2, n.º 2 (31 de agosto de 2022): 85. http://dx.doi.org/10.52365/jecp.v2i2.423.
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Ocimum spp. merupakan salah satu tanaman yang digunakan sebagai bahan obat tradisional, karena memiliki senyawa antioksidan, antikanker dan antimikroba. Tujuan penelitian ini adalah untuk mengetahui senyawa fitokimia dan potensi antimikroba ekstrak Herba Kemangi (Ocimum americanum L.) terhadap Staphylococcus aureus, Salmonella typhi dan Candida albicans berdasarkan zona hambat. Ekstraksi dilakukan dengan maserasi menggunakan etanol 96%. Metode kerja yang digunakan yaitu pembuatan simplisia, ekstraksi, skrining fitokimia, pengujian aktivitas antimikroba dengan metode disc diffusion. maka diperoleh rata-rata zona hambat pada bakteri Staphylococcus aureus konsentrasi 2% b/v sebesar 11,3 mm, 4% b/v sebesar 14,3mm, 8% b/v sebesar 17,6 mm, kontrol positif (clindamycin) sebesar 26 mm dan kontrol negatif 0 mm. Pada bakteri Salmonella typhi konsentrasi 2% b/v sebesar 12,6 mm, 4% b/v sebesar 15,6 mm, 8% b/v sebesar 19,3 mm, kontrol positif (ciprofloxacin) sebesar 29,3 mm dan kontrol negatif 0 mm. Pada Candida albicans konsentrasi 2% b/v sebesar 0 mm, 4% b/v sebesar 6,6 mm, 8% b/v sebesar 8,3 mm, kontrol positif (nystatin) sebesar 12,3 mm dan kontrol negatif 0 mm.Ocimum spp. is one of the plants used as ingredients in traditional medicine, because it has antioxidant, anticancer and antimicrobial compounds. The purpose of this study was to determine the phytochemical compounds and antimicrobial potential of the Herba Basil extract ( Ocimum americanum L.) against Staphylococcus aureus , Salmonella typhi and Candida albicans based on the zone of inhibition. Extraction was carried out by maceration using 96% ethanol. The working method used is the manufacture of simplicia, extraction, phytochemical screening, antimicrobial activity testing with the disc diffusion method . the average inhibition zone of Staphylococcus aureus was 11.3 mm, 4% w/v was 14.3 mm, 8% w/v was 17.6 mm, positive control (clindamycin) was 26 mm and 0 mm negative control. In Salmonella typhi the concentration of 2% w/v was 12.6 mm, 4% w/v was 15.6 mm, 8% w/v was 19.3 mm, positive control (ciprofloxacin) was 29.3 mm and control negative 0 mm. In Candida albicans the concentration of 2% w/v was 0 mm, 4% w/v was 6.6 mm , 8% w/v was 8.3 mm, positive control (nystatin) was 12.3 mm and negative control was 0 mm.
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Miyawaki, Shuichi, Shigeki Ohtake, Shin Fujisawa, Hitoshi Kiyoi, Katsuji Shinagawa, Noriko Usui, Kohichi Miyamura et al. "Long-Term Follow-up of the Randomized JALSG AML 201 Study Comparing High Dose Ara-C Therapy with Conventional Consolidation Therapy in Adult Acute Myeloid Leukemia (AML)". Blood 112, n.º 11 (16 de novembro de 2008): 135. http://dx.doi.org/10.1182/blood.v112.11.135.135.
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Abstract A randomized study had been performed between December 2001 and December 2005 to assess the optimal post remission therapy for adult AML in the first CR. The updated results are here presented, after a median follow-up of 48 months. JALSG AML201 enrolled 1064 previously untreated AML patients (pts) aged 15–64 yrs. The induction therapy consisted of cytarabine (Ara-C 100 mg/m2 day1–7) and idarubicin (IDR 12 mg/m2 day1–3) (arm A) or cytarabine (100 mg/m2 day1–7) and daunorubicin (DNR 50 mg/m2 day1–5) (arm B). If the patients did not achieve remission after the first induction therapy, then the same therapy was given once more. Pts were categorized into good, intermediate or poor risk groups by risk factors based on the criteria established in previous JALSG AML studies (Miyawaki et al. Cancer 2005). All CR pts were stratified according to the induction, the number of courses of induction, age and karyotype and were randomly assigned to the high dose Ara-C (HDAC) post remission regimen (arm C) or the conventional JALSG post remission regimen (arm D). Arm C: the three courses of HDAC which consisted of Ara-C 2.0 g/m2 q12h day1–5, arm D: the first course consisted of Ara-C 200 mg/m2 day1–5+ mitoxantrone (MIT) 7 mg/m2 day1–3, 2) Ara-C 200 mg/m2 day1–5+ DNR 50 mg/m2 day1–3, 3) Ara-C 200 mg/m2 day1–5+ aclarubicin (ACR) 20 mg/m2 day15, 4) Ara-C 200 mg/m2 day1–5+ etoposide (ETP) 100 mg/m2 day1–5 + vincristine (VCR) 0.8 mg/m2 day 8 + vindesine (VDS) 2 mg/m2 day10. Results: Of the 1064 pts registered, 1057 pts (median age: 47 years) were evaluable. 823 pts (78%) achieved CR after one or two courses of induction therapy. Of the 823 pts in CR, 781 pts were assigned to arm C (n=389) or arm D (n=392). The 5-year OS rate of arm C was 57.8% while that of arm D was 55.9% (p=0.96). The 5-year RFS rate of the CR pts was 42.7% in arm C and 38.9% in arm D (p=0.73). Among the good risk group (n=155), the 5-year OS rate of arm C was 69.9% while that of arm D was 80.5 % (p=0.11), and the 5-year RFS rate of arm C was 54.5% while that of arm D was 55.7% (p=0.53). Among the intermediate risk group (n=439), the 5-year OS rate of arm C was 50.9% while that of arm D was 48.5% (p=0.59), and the 5-year RFS rate of arm C was 41.5% while that of arm D was 36.5% (p=0.50). Among the poor risk group (n=49), the 5-year OS rate of arm C was 12.9% while that of arm D was 17.2% (p=0.58), and the 5-year RFS rate of arm C was 14.3% while that of arm D was 15.5% (p=0.78). In the CBF leukemia group (n=218), the 5-year OS rate of arm C was 75.0% while that of arm D was 65.8% (p=0.17), and the 5-year RFS rate of arm C was 56.5% while that of arm D was 38.7% (p=0.05). Among the young group (<50yrs) (n=467), the 5-year OS rate of arm C was 62.1% while that of arm D was 66.4% (p=0.23), and the 5-year RFS rate of arm C was 44.6% while that of arm D was 45.6% (p=0.59). Among the old group (>=50 yrs) (n=314), the 5-year OS rate of arm C was 51.3% while that of arm D was 40.1% (p=0.16), and the 5-year RFS rate of arm C was 40.0% while that of arm D was 28.1% (p=0.23). After all of consolidation, the lowest WBC count and the duration of neutropenia in arm C were significantly lower and longer than those in arm D. There was a higher rate of documented infection in arm C (20.9%) than in arm D (14.5%) (p< 0.001). Conclusion: The conventional post remission therapeutic regimen established by JALSG consisting of 4 courses of consolidation was found to be as effective as the three courses of HDAC therapy. HDAC therapy produced a slightly positive effect on RFS in only the CBF leukemia group.
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Wang, You-bao, Wei-ping Liu, Xi-xiang Bai, Zhi-chang Li, An-li Li, Shu-hua Zhou, Xiao-feng Zhu et al. "Angular Distribution for 7 Be(d, n) 8 B Reaction at E c.m. = 8.3 MeV and the Astrophysical S 17 (0) Factor for 7 Be(p, γ) 8 B Reaction". Chinese Physics Letters 16, n.º 12 (1 de dezembro de 1999): 873–75. http://dx.doi.org/10.1088/0256-307x/16/12/006.
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Agarwal, Alka, Shiv K. Agarwal, Som Nath Singh, Nigar Fatma e R. K. Chatterjee. "Structure-Antifilarial Activity Relationship of 5/6/7/8-Mono-or Disubstituted 1H/1-Phenyl-9H-pyrido[3,4-b]indoles -A New Class of Potential Filaricides". Zeitschrift für Naturforschung C 49, n.º 7-8 (1 de agosto de 1994): 526–30. http://dx.doi.org/10.1515/znc-1994-7-821.
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Antifilarial activity of 5/6/7/8-mono-or disubstituted 1 H /1-phenyl-9H -pyrido[3,4-b]indoles (I) has been described. The 1,6-and 8 -substituted 9H-pyrido[3,4-b]indoles (I) elicited interesting filaricidal activity against Litomosoides carinii and Acanthocheilonema viteae in rodent hosts
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Sangtam, Noklangkumla, Sunanda Haorongbam, Kshetrimayum Silpa e Yumnam Priyabarta Singh. "Bronchiectasis in patients with chronic obstructive pulmonary disease in a tertiary care center in North-East India". International Journal of Advances in Medicine 7, n.º 4 (21 de março de 2020): 656. http://dx.doi.org/10.18203/2349-3933.ijam20201118.
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Background: Bronchiectasis is common in patients with Chronic Obstructive Pulmonary Disease (COPD). COPD with bronchiectasis has been considered a phenotype with worse lung function and more severe exacerbations. There is scarce literature on the characteristics and optimal management of such patients.Methods:Patients with COPD reporting within the one-year study period were subjected to High Resolution Computed Tomography (HRCT) scan of the thorax. Sputum was sent for Gram-stain and culture/sensitivity for patients found to have bronchiectasis. Bronchiectasis Severity Index (BSI) was calculated using the online BSI calculator. Association between presence of bronchiectasis and gender, lung function and frequency of exacerbations was statistically analysed.Results: Total 62 patients with COPD were enrolled. Bronchiectasis was present in 11 (17.7%) patients. The most common bacterial isolate from sputum of patients with bronchiectasis was Haemophilus influenza (54.54%). The prevalence of bronchiectasis was more in females (19.45% compared to 15.4% in males), but this association was not found to be statistically significant(p=0.748). Forced Expiratory volume in 1st second (FEV1) was found to be significantly lower in patients with bronchiectasis (p<0.05). There was increased frequency of exacerbations among patients with bronchiectasis. This association was however not found to be statistically significant (p=0.765), 1 (9.1%) patient had low BSI score (0-4), 3 (27.3%) patients had intermediate BSI score (5-8) and 7 (63.3%) patients had high BSI score (≥9).Conclusions:The presence of bronchiectasis in COPD is a phenotype associated with a poor clinical course. The characteristics of this co-existence are largely unknown. More studies are required to properly characterize and manage patients with this coexistence. 1. Global Initiative for Chronic Obstructive Lung Disease Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease. 2014. Available at: http://wwwgoldcopdorg/. Accessed 1 February, 20182. Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease 2019 report. Available at: https://goldcopd.org/wp-content/uploads/2018/11/GOLD-2019-v1.7-FINAL-14Nov2018-WMS.pdf. Accessed 24 January 2019.3. Martínez-García MA, de la Rosa Carrillo D, Soler-Cataluña JJ, Donat-Sanz Y, Serra PC, Lerma MA, et al. Prognostic value of bronchiectasis in patients with moderate-to-severe chronic obstructive pulmonary disease. Am J Respirat Crit Care Med. 2013 Apr 15;187(8):823-31.4. Pasteur MC, Bilton D, Hill AT. British Thoracic Society guideline for non-CFbronchiectasis. Thorax. 2010 Jul 1;65(Suppl 1):i1-58.5. Mao B, Lu HW, Li MH, Fan LC, Yang JW, Miao XY, et al. The existence of bronchiectasis predicts worse prognosis in patients with COPD. Scientific reports. 2015 Jun 16;5:10961.6. Jin J, Yu W, Li S, Lu L, Liu X, Sun Y. Factors associated with bronchiectasis in patients with moderate-severe chronic obstructive pulmonary disease. Med (Baltimore) 2016;95(29):e4219.7. Du Q, Jin J, Liu X, Sun Y. Bronchiectasis as a co morbidity of chronic obstructive pulmonary disease: a systematic review and meta-analysis. PLoS One. 2016;11(3):e0150532.8. Ni Y, Shi G, Yu Y, Hao J, Chen T, Song H. Clinical characteristics of patients with chronic obstructive pulmonary disease with co morbid bronchiectasis: a systemic review and meta-analysis. Int J Chron Obstruct Pulmon Dis. 2015;10:1465-75.9. Loebinger MR, Wells AU, Hansell DM, Chinyanganya N, Devaraj A, Meister M, et al. Mortality in bronchiectasis: a long-term study assessing the factors influencing survival. Eur Respir J. 2009;34(4):843-9.10. Rakhimova E, Wiehlmann L, Brauer AL, Sethi S, Murphy TF, Tummler B. Pseudomonas aeruginosa population biology in chronic obstructive pulmonary disease. J Infect Dis. 2009;200(12):1928-35.11. Chalmers JD, Goeminne P, Aliberti S, McDonnell MJ, Lonni S, Davidson J, et al. The bronchiectasis severity index. An international derivation and validation study. Am J Respir Crit Care Med. 2014;189(5):576-85.12. Dou S, Zheng C, Cui L, Xie M, Wang W, Tian H, et al. High prevalence of bronchiectasis in emphysema-predominant COPD patients. Int J Chron Obstruct Pulmon Dis. 2018;13:2041-7.13. Ramakrishna R, Ambica A. Association of Bronchiectasis in Moderate to Severe COPD patients attending Katuri Medical College Hospital, Guntur from 2011-2013. J Evidence Based Med Healthcare 2015;2(13):2062-76.14. Martinez-Garcia MA, Soler-Cataluna JJ, Donat Sanz Y, Catalan Sera P, Agramunt Lerma M, Ballestin Vicente J, et al. Factors associated with bronchiectasis in patients with COPD. Chest 2011;140(5):1130-7.15. Kumar S, Singh GV, Gupta RK, Singh H, Prakash G. To estimate the prevalence of bronchiectasis in COPD patients. IOSR JDMS. 2018;17(3):82-90.16. Woodhead M, Blasi F, Ewig S. Guidelines for the management of adult lower respiratory tract infections. Eur Respir J. 2005;26:1138-80.17. Patel IS, Vlahos I, Wilkinson TM, Lloyd-Owen SJ, Donaldson GC, Walks M, et al. Bronchiectasis, Exacerbation indices and Inflammation in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2004;170(4):400-7.18. Chen YH, Sun YC. Bronchiectasis as a co morbidity of chronic obstructive pulmonary disease: implications and future research. Chin Med J (Engl). 2016;129(17):2017-9.19. Gatheral T, Kumar N, Sansom B. COPD-related bronchiectasis; independent impact on disease course and outcomes. COPD. 2014;11(6):605-14.20. Goeminne PC, Nawrot TS, Ruttens D, Seys S, Dupont LJ. Mortality in non-cystic fibrosis bronchiectasis: a prospective cohort analysis. Respir Med. 2014 Feb 1;108(2):287-96.21. Hurst JR, Elborn JS, De Soyza A. COPD–bronchiectasis overlap syndrome. Eur Respir J. 2015;45:310-3.
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Nagler, Adi, Shelly Kalaora, Deborah Gitta Rosenberg, Michal Alon, Eilon Barnea, Ronen Levy, Kevin Vervier et al. "672 Identification of microbial-derived HLA-bound peptides in melanoma". Journal for ImmunoTherapy of Cancer 8, Suppl 3 (novembro de 2020): A710. http://dx.doi.org/10.1136/jitc-2020-sitc2020.0672.
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BackgroundThe query for tumor shared and neo-antigens as a therapeutic approach has been the focus of cancer immunology for the past two decades. Notably, these peptide sequences can bind to HLA molecules and present on the cell surface, subsequently to be recognized by T-cell receptors (TCRs), activating the immune system and so facilitating in tumor rejection.1–3 The search for new origins of targetable types of HLA peptides is consistently growing, and new studies show peptides that are derived from non-canonical open reading frames (ORFs), altered translation, proteasome splicing, viral proteins and more.4–6 In light of the new findings, showing the important role of intra-tumor and gut bacteria in tumor-genesis and their effect on the immune response,7–10 we went on a quest for discovering whether intracellular bacteria antigens can be presented by tumor cells, and whether these antigens may elicit an immune response.MethodsCombination of HLA peptidomics with 16S rDNA sequencing.ResultsCombination of HLA peptidomics with 16S rDNA sequencing of 17 melanoma metastasis derived from 9 different patients, lead us to the unbiased identification of an intracellular bacterial peptide repertoire presented on HLA-I and HLA-II molecules. We were able to validate these results by co-culturing the bacterial species identified by 16S sequencing with the patient derived melanoma cells, further validating the peptide’s presentation by preforming HLA peptidomics on the infected cells. Importantly, we were able to identify common bacterial peptides from different metastases of the same patient as well as from different patients. Some of the common bacterial peptides, as well as others, were able to elicit an immune response by the autologous tumor infiltrating lymphocytes (TILs), suggesting potential therapeutic implications of these peptides.ConclusionsThe insights gathered through this study elucidate the effect of intra-tumor bacteria on the immune response and so, may lead to the development of novel clinical applications.ReferencesNeefjes J, Jongsma ML, Paul P, Bakke O. Towards a systems understanding of MHC class I and MHC class II antigen presentation. Nat Rev Immunol 2011;11: 823–836.Stronen E, Toebes M, Kelderman S, et al. Targeting of cancer neoantigens with donor-derived T cell receptor repertoires. Science 2016; 352: 1337–1341.Rosenberg SA, Restifo NP. Adoptive cell transfer as personalized immunotherapy for human cancer. Science 2015; 348: 62–68.Chen J, Brunner AD, Cogan JZ, et al. Pervasive functional translation of noncanonical human open reading frames. Science 2020; 367: 1140–1146.Starck SR, Shastri N. Nowhere to hide: unconventional translation yields cryptic peptides for immune surveillance. Immunol Rev 2016;272:8–16.Croft NP, Smith SA, Pickering J, et al. Most viral peptides displayed by class I MHC on infected cells are immunogenic. Proc Natl Acad Sci U S A 2019; 116: 3112–3117.Gopalakrishnan V, Spencer CN, Nezi L, et al. Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients. Science 2018;359:97–103.Routy B, Le Chatelier E, Derosa L, et al. Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors. Science 2018;359:91–97.Matson V, Fessler J, Bao R, et al. The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma patients. Science 2018;359:104–108.10. Nejman D, Livyatan I, Fuks G et al. The human tumor microbiome is composed of tumor type-specific intracellular bacteria. Science 2020;368:973–980.
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Pfreundschuh, Michael, Evelyn Kuhnt, Lorenz Trümper, Anders Osterborg, Marek Trneny, Lois Shepherd, Devinder S. Gill et al. "Randomised Intergroup Trial of First line Treatment for young Low-Risk Patients (<61 years) with Diffuse Large B-Cell Non-Hodgkin's Lymphoma (DLBCL) with a CHOP-like Regimen with or without the Anti-CD20 Antibody Rituximab – 6-Year Follow-up of the Mint Study of the Mabthera International Trial (MInT) Group". Blood 116, n.º 21 (19 de novembro de 2010): 111. http://dx.doi.org/10.1182/blood.v116.21.111.111.
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Abstract Abstract 111 Background: The addition of rituximab to CHOP-21 significantly improved clinical outcome in elderly patients with DLBCL (Coiffier et al., 2002). The MInT trial, randomized young good-prognosis patients to receive a CHOP-like regimen or the same CHOP-like regimen plus rituximab, and was stopped early because of superiority of the rituximab arm, and results were published with a median follow-up of 34 months (Pfreundschuh et al., Lancet Oncology 2006; 379-91). Objective: Because the MInT study was the first study to show a survival benefit with the addition of rituximab to a CHOP-like regimen in young good-prognosis patients, extended follow-up is important to determine whether the survival benefit is maintained over time and whether a definitive effect on cure rates can be shown. Methods: In a phase III intergroup study with participating cooperative groups from 18 countries, previously untreated patients (18-60 years) with low-risk DLBCL (age-adjusted IPI 0 or 1, stages II-IV and stage I with bulky disease) were randomized to receive 6 cycles of a CHOP-like regimen (CHEMO) or the same chemotherapy plus rituximab 375 mg/m2, given on day 1 of each 3-week regimen and on days 1, 22, 43, 64, 85 and 106 of the 2-week regimens, respectively (R-CHEMO). Radiotherapy (30-40 Gy) was planned to sites of initial bulky disease and/or extranodal involvement. The primary endpoint was event-free survival (EFS) with events defined as failure to achieve complete remission, progressive disease, relapse, death or additional therapy. The trial was powered to show a 10% difference in EFS rate after 3 years. Results: Between 05/2000 and 10/2003 a total of 823 patients were recruited of whom 396 were allocated to receive CHOP-21, 361 to CHOEP-21, 34 to MACOP-B, and 32 to PMitCEBO with or without rituximab. Toxicity, incidence of adverse events and severe adverse events in the CHEMO and the R-CHEMO arms were not significantly different. After a median follow-up of 70 (0.03-117) months, patients assigned to chemotherapy and rituximab had increased 6-year event-free survival compared with those assigned to chemotherapy alone (74.0% [95% CI 69.0–78.3] vs 55.7% [50.3-60.8]; log-rank p<0·0001), increased 6-year progression-free survival (79.9% [75.1 - 83.8%] vs 63.8% [58.2-68.8]; log-rank p<0.001) and increased overall survival (89.8% [86.0-92.6] vs 80.0% [75.3-83.9; log rank p=0.001). In a multivariate analysis event-free survival was affected by the addition of rituximab (hazard ratio [HR] 0.49, p< 0.001), age-adjusted IPI (HR 1.73, p<0.001), and bulky disease (HR 1.43, p=0.004). Similar effects were observed for OS, while PFS was affected by treatment arm (HR 0.49, p<0.001) and age-adjusted IPI (HR 1.8, p<0.001). As a consequence, a very favorable subgroup (aaIPI=0, no bulky) can be distinguished from a less favorable subgroup (aaIPI=1 and/or bulky disease) among good-prognosis patients treated with rituximab. There were 10 late (>60 months) events after CHEMO (61.4 to 96.1 months), including 4 in the very favorable subgroup, while all 8 late events (67.5 to 105.7 months) after R-CHEMO occurred in the less favorable subgroup only, and none in the very favorable subgroup. Conclusion: Addition of rituximab to a CHOP-like regimen leads to a significant improvement of the outcome in young patients with good-prognosis diffuse large B-cell lymphoma, with significant survival benefit maintained during a 6-year follow-up. However, except in the very favorable subgroup after R-CHEMO, late relapses after 5 years occur. While reduction of treatment in a randomized study like the FLYER trial of the DSHNHL is justified, further progress, e.g. by dose densification (UNFOLDER trial of the DSHNHL) and/ or dose escalation is still warranted for the less favorable subgroup. Supported by Roche, Deutsche Krebshilfe and KML. Disclosures: Pfreundschuh: Roche: Consultancy, Membership on an entity's Board of Directors or advisory committees; GSK: Membership on an entity's Board of Directors or advisory committees; Pfizer: Membership on an entity's Board of Directors or advisory committees; Amgen: Membership on an entity's Board of Directors or advisory committees. Trneny:Roche: Honoraria, Research Funding. Walewski:Roche: Honoraria, Research Funding. Pettengell:Roche: Honoraria. Jäger:Roche: Honoraria, Research Funding. Lopez-Guillermo:Roche: Consultancy.
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Mazacón Gómez, Martha Narcisa, Cindy del Rocío Paliz Sánchez e Luis Antonio Caicedo Hinojosa. "LAS COMPETENCIAS PROFESIONALES DE LA ENFERMERÍA Y SU EFECTO EN LA LABOR PROFESIONAL". Universidad Ciencia y Tecnología 24, n.º 105 (11 de outubro de 2020): 72–78. http://dx.doi.org/10.47460/uct.v24i105.383.
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Distintos autores aseguran que el desarrollo profesional de la enfermería debe tener un enfoque vinculante que relacione la gestión, la administración y las competencias profesionales. La enfermería es hoy una profesión de primer orden en el sistema de salud universal, reconocida como protagonista principal en el cuidado y atención del paciente, lo que obliga a estos profesionales conocimientos actualizados que se manifiestan en su desempeño. Por ello, esta investigación examina las teorías sobre competencia, gestión y la administración en el ejercicio de la enfermería, mediante una revisión bibliográfica en bases de datos atendiendo los criterios de inclusión y exclusión elegidos. Una vez realizada la búsqueda se seleccionaron 11 documentos relacionados con el objetivo de la investigación. Sobre la base de una revisión crítica del referencial teórico, se identificó los conocimientos, capacidad, liderazgo, compromiso social y comunicación de la enfermería como eje central en el cuidado integral del paciente y el desarrollo integral del profesional de la enfermería.
Palabras Clave: gestión, administración, enfermería, calidad profesional.
Referencias
[1]A.Orellana y O. Sanhueza, "Competencia en investigación en enfermería," Ciencia y Enfermería, vol. XVII, nº 2, p. 15-23, 2011.
[2]Consejo Internacional de enfermeras , "Informe del proceso de elaboración de consultas del Consejo Internacional de enfermeía", Munich, 2003.
[3]Sociedad Española de Enfermería , "Competencias de enfermería en urgencias y emergencia", Ginebra, 1998.
[4]P.Ramritu y D. Barnard, "Cómo comprenden la competencia los enfermeros recien licenciados", International Nursing Review version española, vol. 48, nº 1, pp. 41-61, 2001.
[5]R.Samper, "Gestion del cuidado de enfermería para la atencion cerrada", Rev Cubana Enfermer, vol. 26, nº 1, pp. 1-12, 2010.
[6]M.Asenjo, "Gestión diaria en el hospital", Rev. Esp. Salud Pública, vol. 3, nº 73, pp. 417-419, 1999.
[7]P.Milos, "La gestion del cuidado en la legislacion Chilena interpretacion y alcance", Cienc. Enfermería, vol. XVI, nº 1, pp. 17-29, 2010.
[8]J.Valdebenito, "Gestión de cuidado: valoración y conocimientos de enfermeros/as de un hospital de la region metropolitana de Chile",Cienc. enf., vol. 21, nº 01, pp. 5-25, 2015.
[9]S.Estefa y J. Paravic, "Enfermería en el rol de gestora de los cuidados",Cienc. Enferm., vol. 16, nº 3, pp. 3-39, 2010.
[10]B. Scalzi y B. Mowinski, "Diffeferentiating nursing leadersip and management competensies", Nurs outlook, vol. 55, nº 1, pp. 169-175, 2007.
[11]H.Koontz y H. Weihrieh, "Introducción a la administración" de Administración una perspectiva global, Mexico, Interamericana Editores, 2016, pp. 15-36.
[12]L.Daderian y C. Arndt, "Breve historia de la teoria de la administración y su aplicación en la enfermería" de Administración de enfermería teoria para la práctica con un enfoque de sistema, California, Copyrignt, 2017, pp. 3-4.
[13]N.Hernandez, "Administración de servicios sanitarios",2014. [En línea]. Available: ciniorte. [Último acceso: 23 07 2020].
[14]Z.Vargas, A. Espinosa, M. Lamadrid y M. Saavedra, "El desempeño de los profesionales de Enfermería", Rev.Cubana de Enfermería, vol. 3, nº 1, Recuperado de: http://www.revenfermeria.sld.cu/index.php/enf/article/view/823/155, 2016.
[15]M.Loreto y L. Soler, Gestion y administración de servicios de enfermería, España, 2019.
[16]C. Gonzalez, N. Barahona, M. Estrada, A. Favela y F. Cuen, "Evaluación de competencias del profesional de enfermería que labora en hospitales públicos y privado", Rev. Elec. Enfermería Actual en Costa Rica , vol. 27, pp. 9-15, 2016.
[17]C. Fernandez, C. López y M. Sánchez, "La gestión del cuidado en la atencion primaria en salud Chile",Rev. iberoam.Educ. investi. Enferm, vol. 8, nº 2, pp. 18-29, 2018.
[18]J.A.Riera, Gestion de cuidados enfermeros, Catalunya: Universidad Oberta de Catlunya, 2014.
[19]F.Aguayo y R. Moraga, "Significado práctico del concepto gestión del cuidado en las enfermeras/os que se desempeñan en atención primaria en salud,"Cienc.enferm., vol. 21, nº 3, pp. 73-85, 2016.
[20]N.Febres y V. Baldilla, "Calidad en enfermería su gestión implementación y medicion", Revista Medica Clinica los Condes, vol. 25,n° 2, pp. 278-287, 2016.
[21]J.R. Beltran, "Gestión de enfermeria y el comportamiento de indicadores de calidad de atención de enfermería,» Revista Médica Clínica Las Condes, vol. 29, nº 3, pp. 269-276, 2018.
[22]S.Martínez, F. Gómez y M. Lara, "El desempeño de los profesionales de enfermería", Revista cubana de enfermería, vol. 32, nº 1, pp. 98-108, 2016.
[23]A.Hernández, "La gestion del cuidado",Revista Enfermería CyL, vol. 7, nº 2, pp. 19-26, 2014.
[24]M.Lavalle y M. Villadiego, "La administración de enfermería en el area clinica y sus implicaciones en el cuidado," Revista colombiana de enfermería, vol. 9, nº 64, pp. 14-23, 2016.
[25]M.Silveira y M. Galan, "Administración del cuidado concordancia entre prescripción de enfermería y necesidades de cuidados en los pacientes", Rlae, vol. 24:e2723., doi.org/10.1590/1518-8345.0645.2723 , 2016.
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Sadek, Kamal Usef, Ramadan Ahmed Mekheimer, Tahany Mahmoud Mohamed, Moustafa Sherief Moustafa e Mohamed Hilmy Elnagdi. "Regioselectivity in the multicomponent reaction of 5-aminopyrazoles, cyclic 1,3-diketones and dimethylformamide dimethylacetal under controlled microwave heating". Beilstein Journal of Organic Chemistry 8 (4 de janeiro de 2012): 18–24. http://dx.doi.org/10.3762/bjoc.8.3.
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The multicomponent reaction of 5-aminopyrazole derivatives with cyclic 1,3-dicarbonyl compounds and dimethylformamide dimethylacetal (DMFDMA) in DMF at 150 °C under controlled microwave heating afforded regioselectively 8,9-dihydropyrazolo[1,5-a]quinazolin-6(7H)-ones 6 rather than the corresponding dihydropyrazolo[5,1-b]quinazolin-8(5H)-ones 4.
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Fajriana, Nurul, Ulia Hanum e Nurhidayatun Rahma. "ETHNOBOTANICAL STUDY IDENTIFICATION OF PLANT TYPES THAT CAN BE USED IN ECOPRINT PRODUCTION". BIOTIK: Jurnal Ilmiah Biologi Teknologi dan Kependidikan 12, n.º 1 (1 de abril de 2024): 12. http://dx.doi.org/10.22373/biotik.v12i1.19431.
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ABSTRACT Used of synthetic dye in the textile industry produced liquid waste if it is not recycle with properly, it can cause pollution and contamination of water both on the surface and every drop used by humans, disrupting ecosystems and even killing life in aquatic ecosystems. Therefore, an alternative to synthetic dye is neededby using plants as natural dye. Leaves can be used for their color content, leaf bones and leaf surfaces can be used as textile motif called ecoprint. This research purposing to find out the types of plants that can be used as materials for making ecoprint as a substitute for synthetic dye and also to find out the parts of plants that can be used as materialfor making ecoprint. The research method used is descriptive qualitative from literature study and literature references regarding data and information related to research. The results showed there are 30 types of plants that can be used in ecoprint. Thishabitus plants is herbaceous, vines, shrubs, shrubs and trees. From herbaceous habitus found 5 species of plants, 3 species of vine habitus, 7 species of bush habitus, 10 species of shrub habitus and 5 species of tree habitus. The parts of plants that can be used in making ecoprints are the leaves, flowers, stems and roots. The results showed there were 30 species of plants from 21 families that could be used in making ecoprint. The parts of plant can be used in making ecoprintare parts, leaves, flowers, stems and roots, but not all parts of every type of plant can be used in the process of making ecoprint. Keywords: Ethnobotanical Studies, Ecoprint, Synthetic Dyes, Natural Dyes, HabitusREFERENCE[1] Lubis, E. F. M. D., Ghea, A., Viola, D. E, dan Soraya, G. D. 2022. Pemanfaatan Daun dan Bunga Tanaman Buah sebagai Pewarna Motif Alami pada Media Jilbab dengan Teknik Ecoprint. Jurnal Senashtek, hal:819-823.[2]Juniar, , S., T. dan Sulandjari S. 2018. Perbedaan Hasil Rok Pias EcoprintDaun Jati (Tectona grandis) Menggunakan Jenis dan Massa Mordan Tawas dan Cuka. Jurnal Tata Busana, 7. [3] Martani, E., Margino S. dan Nurnawati E. 2011. Isolasi Dan Karakterisasi Jamur Pendegradasi Zat Pewarna Tekstil (Isolation and Characterization of Dye-degrading Fungi). Jurnal Manusia dan Lingkungan, 18, 127-136. [4] Subagyo, P., K. & Seolistyowati. 2021. Pengaruh Zat Pewarna Sintetis terhadap Pewarnaan Kain Batik. Jurnal FOLIO. Vol. 2., No., 2. [5]Komarawidjaja, W. 2016. Sebaran Limbah Cair Industri Tekstil dan Dampaknya pada Beberapa Desa Kecamatan Rancaekek Kabupaten Bandung. Jurnal Teknologi Lingkungan. Vol. 17. No. 2., hal: 118-125. [6] Enrico. 2019. Dampak Limbah Cair Industri Tekstil Terhadap Lingkungan dan Aplikasi Tehnik Eco Printing sebagai Usaha Mengurangi Limbah. Jurnal MODA. Vol.1., No. 1. [7] Masyitoh F. dan Ernawati E. 2019. Pengaruh Mordan Tawas dan Cuka Terhadap Hasil Pewarnaan Ecoprint Bahan Katun Menggunakan Daun Jati (Tectona grandis). Gorga Jurnal Seni Rupa, 8, 387-391. [8] Saraswati, R., M. H. Dewi, S., Ratri, C. R., Fajar, D. P. 2019. Pemanfaatan Daun untuk Ecoprint dalam Menunjang Pariwisata. Depok: Departemen Geografi FMIPA UI. [9] Wirawan, B., M. Alvin. 2019. Teknik Pewarnaan Alam Ecoprint Daun Ubi dengan Penggunaan Fiksator Kapur, Tawas dan Tunjung. Jurnal Litbang Kota Pekalongan: Vol. 17:1-5. [10] Simanungkalit, Y., S. 2020. Teknik Ecoprint dengan Memanfaatkan Limbah Mawar (Rosa Sp.) pada Kain Katun. Skripsi. Semarang: UNNES. [11] Sugiyono, 2013. Metode Penelitian Pendidikan Pendekatan Kuantitatif, Kualitatif; Research & Development. Bandung: Alfabeta. [12] Baharuddin A., Aisyah A., Saokani J. dan Risnah I. A. 2015. Karakterisasi Zat Warna Daun Jati (Tectona Grandis) Fraksi Metanol: N-Heksana sebagaiPhotosensitizer pada Dye Sensitized Solar Cell. Chimica et Natura Acta, 3. [13] Kembaren R., Putriliniar S., Maulana N., Yulianto K., Ikono r., Rochman N. T.dan Mardliyati, E. 2014. Ekstraksi dan Karakterisasi Serbuk Nano Pigmen dari Daun Tanaman Jati (Tectona grandis linn. F). Jurnal Kimia dan Kemasan, 36.[14] Sulistiawati E. dan Swastika P. 2017. Ekstraksi Zat Warna Alami dari Daun JatiMuda (Tectona grandis) dan Kayu Secang (Caesalpinia sappan) dengan Metode Ultrasound Assisted Extraction untuk Aplikasi Produk Tekstil. Skrispsi. Surabaya:InstitutTeknologi Sepuluh Nopember. [15] Koswara S. 2009. Pewarna Alami Produksi dan Penggunaannya. Ebook Pangan. [16] Haffida A. A. N. dan Rahardhian F. D. 2017. Ekstraksi Zat Tanin Dari Bahan Alami Dengan Metode Steam Extraction.Skrispsi. Surabaya:Institut Teknologi Sepuluh Nopember.
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Berman, Michelle Krutan, Martha L. Taylor e Ellen Freeman. "Vitamin B-6 in premenstrual syndrome ",. Journal of the American Dietetic Association 90, n.º 6 (junho de 1990): 859–61. http://dx.doi.org/10.1016/s0002-8223(21)01644-8.
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Behre, Ulrich, Gerhard Bleckmann, Priya Diana Crasta, Maarten Leyssen, Marc Messier, Jeanne Marie Jacquet e Karin Hardt. "Clarification to Long-term anti-HBs antibody persistence and immune memory in children and adolescents who received routine childhood hepatitis B vaccination. Hum Vaccin Immunother 2012; 8:813-8". Human Vaccines & Immunotherapeutics 8, n.º 6 (12 de junho de 2012): 813–18. http://dx.doi.org/10.4161/hv.19898.
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Sonneveld, P., R. Hajek, A. Nagler, A. Spencer, J. Bladé, T. Robak, S. H. Zhuang, J. L. Harousseau, S. Fruchtman e R. Z. Orlowski. "Impact of prior thalidomide (T) therapy on the efficacy of pegylated liposomal doxorubicin (PLD) and bortezomib (B) in relapsed/refractory multiple myeloma (RRMM)". Journal of Clinical Oncology 25, n.º 18_suppl (20 de junho de 2007): 8023. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.8023.
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8023 Background: IMIDs and proteasome inhibitors offer novel therapeutic options for patients with RRMM. T+Dex is approved for the treatment of newly diagnosed MM (Rajkumar JCO 2006). Wang et al (ASCO 2006, ASH 2006) suggested prior T exposure resulted in partial cross resistance to subsequent treatment with lenalidomide (L). Our objectives were to determine 1) whether resistance also existed to PLD+B in patients receiving prior T vs no prior T and 2) if the efficacy and safety profile of PLD+B was comparable to that previously reported with L+Dex in T failures. Methods: We performed a post hoc analysis of a previously reported phase III trial comparing PLD+B vs B alone (Orlowski ASH 2006). RRMM patients receiving ≥1 prior therapy and randomized to receive PLD at 30 mg/m2 given on D4 of each cycle along with B at 1.3 mg/m2 on D1, 4, 8, and 11 of every 21-day cycle were analyzed based on prior T exposure or no prior T. Treatment was continued for up to 8 cycles or for at least 2 cycles beyond a CR unless disease progression was observed or unacceptable toxicity occurred. Results: 324 patients were randomized to PLD+B (n=194 [T naïve], n=130 [T exposed]) and included in this analysis. Baseline albumin was 3.8 g/dL, 3.8 g/dL and 4.8 g/dL for the PLD+B (T naïve), PLD+B (T exposed) and L+Dex (T exposed), respectively. Baseline β2 microglobulin was 5.2 g/dL, 5.4 g/dL and 3.7 g/dL for these groups, respectively. Conclusions: These results demonstrate that PLD+B provide a consistent efficacy benefit in both T exposed and T naïve patients with no evidence of cross resistance to prior T. Compared to L+Dex in a similar patient population with prior T exposure, PLD+B has comparable response rates and time to progression, but the risk of TVE is substantially reduced. These results should be considered when choosing treatment options for RRMM who have failed prior T treatment and confirmed in a prospective randomized study. [Table: see text] [Table: see text]
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Wiharta, Adnan S., Evi Setiadi, H. M. Sjaifullah Noer, Triyatmo Rachimhadhi e Asri Rasad. "HBsAg in Cord Blood Qf Newborns of HBsAg-Positive Mothers". Paediatrica Indonesiana 34, n.º 5-6 (5 de novembro de 2018): 125–8. http://dx.doi.org/10.14238/pi34.5-6.1994.125-8.
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Vertical transmission of hepatitis B infection that may occur during pregnancy at delivery-, in infancy, and early childhood has an important role in the development of chronic hepatitis B. Intrauterine infection is suspected to occur when hepatitis B viruses cross the placenta into fetal circulation due to failure of placental tissue function. In Cipto Mangunkusumo Hospital, Jakarta, 98 (6.4%) of 1536 pregnant mothers obseiVed during 3 years (1987 -1990) showed positive HBsAg. Six (8.3%) of 60 babies of born to HBsAg positive mothers showed positive HBsAg in their cord blood, but this disappeared after one month. All babies born to HBsAg positive mothers were vaccinated on months 0, 1, 2, and 12. HBsAg in cord blood might not play an important role in vertical transmission.
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Lipscomb, Barney. "Tropical Plants of Costa Rica: A Guide to Native and Exotic Flora. Second Edition". Journal of the Botanical Research Institute of Texas 16, n.º 1 (15 de julho de 2022): 76. http://dx.doi.org/10.17348/jbrit.v16.i1.1245.
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Willow Zuchowski. 2022. Tropical Plants of Costa Rica: A Guide to Native and Exotic Flora. Second Edition. (ISBN-13: 978-1-5017-6307-6, pbk). Zona Tropical, Cornell University Press, Sage House, 512 East State St., Ithaca, New York 14850, U.S.A. (Orders: cornellpress.cornell.edu). $34.95 US, 543 pp., 820 color photographs, 120 b/w illustrations, references, index, 5" × 8".
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Kaur, Manpreet, Jerry P. Jasinski, Channappa N. Kavitha, Hemmige S. Yathirajan e K. Byrappa. "[2-(Benzylideneamino)-4,5,6,7-tetrahydrobenzo[b]thiophen-3-yl](phenyl)methanone". Acta Crystallographica Section E Structure Reports Online 70, n.º 5 (2 de abril de 2014): o507—o508. http://dx.doi.org/10.1107/s1600536814006679.
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In the title compound, C22H19NOS, the cyclohexene ring of the tetrahydrobenzothiophenyl ring system adopts a slightly distorted half-chair conformation and is twisted slightly [7.5 (8)° for the major disorder component] from the mean plane of the thiophene ring. The dihedral angles between the mean planes of the thiophene ring and the phenyl rings are 65.7 (3) and 8.3 (4)°. The phenyl rings are twisted with respect to each other by 73.8 (7)°. Disorder was modeled for four C atoms of the cyclohexene ring over two sets of sites with an occupancy ratio of 0.659 (2):0.341 (2). In the crystal, a single weak C—H...O interaction links the molecules into [001] chains.
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Betti, S. K., K. B. Follette, K. Ward-Duong, Y. Aoyama, G. D. Marleau, J. Bary, C. Robinson et al. "Near-infrared Accretion Signatures from the Circumbinary Planetary-mass Companion Delorme 1 (AB)b*". Astrophysical Journal Letters 935, n.º 1 (1 de agosto de 2022): L18. http://dx.doi.org/10.3847/2041-8213/ac85ef.
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Abstract Accretion signatures from bound brown dwarf and protoplanetary companions provide evidence for ongoing planet formation, and accreting substellar objects have enabled new avenues to study the astrophysical mechanisms controlling the formation and accretion processes. Delorme 1 (AB)b, a ∼30–45 Myr circumbinary planetary-mass companion, was recently discovered to exhibit strong Hα emission. This suggests ongoing accretion from a circumplanetary disk, somewhat surprising given canonical gas disk dispersal timescales of 5–10 Myr. Here, we present the first NIR detection of accretion from the companion in Paβ, Paγ, and Brγ emission lines from SOAR/TripleSpec 4.1, confirming and further informing its accreting nature. The companion shows strong line emission, with L line ≈ 1–6 × 10−8 L ⊙ across lines and epochs, while the binary host system shows no NIR hydrogen line emission (L line < 0.32–11 × 10−7 L ⊙). Observed NIR hydrogen line ratios are more consistent with a planetary accretion shock than with local line excitation models commonly used to interpret stellar magnetospheric accretion. Using planetary accretion shock models, we derive mass accretion rate estimates of M ̇ pla ∼ 3 –4 × 10−8 M J yr−1, somewhat higher than expected under the standard star formation paradigm. Delorme 1 (AB)b’s high accretion rate is perhaps more consistent with formation via disk fragmentation. Delorme 1 (AB)b is the first protoplanet candidate with clear (signal-to-noise ratio ∼5) NIR hydrogen line emission.
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Matio Kemkuignou, Blondelle, Christopher Lambert, Marc Stadler, Simeon Kouam Fogue e Yasmina Marin-Felix. "Unprecedented Antimicrobial and Cytotoxic Polyketides from Cultures of Diaporthe africana sp. nov." Journal of Fungi 9, n.º 7 (24 de julho de 2023): 781. http://dx.doi.org/10.3390/jof9070781.
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Four unprecedented polyketides named isoprenylisobenzofuran B (2), isoprenylisobenzofuran C1/C2 (3), diaporisoindole F1/F2 (4), and isochromophilonol A1/A2 (7) were isolated from ethyl acetate extracts of the newly described endophytic fungus Diaporthe africana. Additionally, the previously reported cyclic depsipeptide eucalactam B (1) was also identified, along with the known compounds diaporisoindole A/B (5), tenellone B (6) and beauvericin (8). The taxonomic identification of the fungus was accomplished using a polyphasic approach combining multi-gene phylogenetic analysis and microscopic morphological characters. The structures 1–8 were determined by a detailed analysis of their spectral data, namely high-resolution electrospray ionization mass spectrometry (HR-ESIMS), 1D/2D nuclear magnetic resonance (NMR) spectroscopy, as well as electronic circular dichroism (ECD) spectra. In addition, chemical methods such as Marfey’s analysis were also employed to determine the stereochemistry in compound 1. All the compounds obtained were evaluated for antimicrobial and in vitro cytotoxic properties. Compounds 3–8 were active against certain fungi and Gram-positive bacteria with MIC values of 8.3 to 66.6 µg/mL. In addition, 3–5 displayed cytotoxic effects (22.0 ≤ IC50 ≤ 59.2 µM) against KB3.1 and L929 cell lines, whereas compounds 6–8 inhibited the growth of seven mammalian cancer cell lines with IC50 ranging from 17.7 to 49.5 µM (6), 0.9 to 12.9 µM (7) and 1.9 to 4.3 µM (8).
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HERRMANN, RACHEL B. "The American Revolutionary War. By STEPHEN CONWAY. New York: I. B. Tauris. 2013. 220 p. £12.99 (pb). ISBN 978-1-84885-813-8." Journal for Eighteenth-Century Studies 37, n.º 4 (6 de novembro de 2014): 601–2. http://dx.doi.org/10.1111/1754-0208.12212.
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Zhang, Chun-Jing, Hai-Jun Pang e Ya-Guang Chen. "Highest Connectivity in a Purely Inorganic 3D Compound Based on Paradodecatungstate-B Clusters: Synthesis and Magnetic Properties". Zeitschrift für Naturforschung B 64, n.º 7 (1 de julho de 2009): 809–14. http://dx.doi.org/10.1515/znb-2009-0706.
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A new paradodecatungstate-B compound, [{Co(H2O)4}4(H4W12O42)]·10H2O (1) of the polyoxometalate series has been synthesized and characterized by elemental analysis, IR and UV spectroscopy, TG analysis, and single-crystal X-ray diffraction. Compound 1 exhibits a unique 8- connected three-dimensional (3D) framework with a (42 · 820 · 126) topology. Moreover, 1 displays antiferromagnetic interactions in the 2 - 300 K temperature range, well reproduced by a simulation procedure.
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Sitorus, Saibun. "Pemanfaatan Abu Sabut Kelapa sebagai Katalis Basa dalam Pembuatan Biodiesel dari Minyak Biji Jarak Pagar (Jatropha curcas. L)". Jurnal Riset Teknologi Industri 9, n.º 1 (31 de agosto de 2016): 50–55. http://dx.doi.org/10.26578/jrti.v9i1.1703.
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The research about utilization ash of coconut husk as source of base catalyst in aplication for reaction of transesterification from Jatropha curcas oil has been researched. Content of base compound in coconut husk ash was analyzed by AAS and acidy alkalimetry. The base catalyst was extracted using methanol, for transesterification reaction of Jatropha curcas oil. This method of biodiesel production by transesterification process used coconut husk ash catalyst by weight variation as much as 2%, 4%, 6%, 8% and 10% (w/w). Analysis of the quality of biodiesel is done with quality parameters acid number, iodine number, density, viscosity and water content in accordance with SNI 04-7182-2006 standards. The result of the research showed that potassium concentration as carbonat salt in the ash of coconut husk was 17,4% (w/w) and the conversion of biodiesel obtained from each catalyst in a row is 43,62%; 78,45%; 76,22%; 75,69% and 63,27% (w/w). Biodiesel optimum results obtained with the addition of the catalyst are 4% with density values of 0.86 (g / mL), the viscosity value of 3.23 (cSt), the value of water content 0.0352%, 0.12 acid number (mg KOH / g) and iodine number of 8.23 (g I2 / 100 g).The research about utilization ash of coconut husk as source of base catalyst in aplication for reaction of transesterification from Jatropha curcas oil has been researched. Content of base compound in coconut husk ash was analyzed by AAS and acidy alkalimetry. The base catalyst was extracted using methanol, for transesterification reaction of Jatropha curcas oil. This method of biodiesel production by transesterification process used coconut husk ash catalyst by weight variation as much as 2%, 4%, 6%, 8% and 10% (w/w). Analysis of the quality of biodiesel is done with quality parameters acid number, iodine number, density, viscosity and water content in accordance with SNI 04-7182-2006 standards. The result of the research showed that potassium concentration as carbonat salt in the ash of coconut husk was 17,4% (w/w) and the conversion of biodiesel obtained from each catalyst in a row is 43,62%; 78,45%; 76,22%; 75,69% and 63,27% (w/w). Biodiesel optimum results obtained with the addition of the catalyst are 4% with density values of 0.86 (g / mL), the viscosity value of 3.23 (cSt), the value of water content 0.0352%, 0.12 acid number (mg KOH / g) and iodine number of 8.23 (g I2 / 100 g).ABSTRAKPenelitian tentang pemanfaatan abu sabut kelapa sebagai sumber katalis basa pada aplikasi reaksi transesterifikasi minyak biji jarak pagar (Jatropha curcas. L) telah dilakukan. Karakterisasi kadar basa dalam sabut kelapa dilakukan dengan AAS dan alkalinitas. Katalis basa diperoleh dengan pengadukan abu sabut kelapa dalam metanol dan selanjutnya digunakan untuk reaksi transesterifikasi minyak biji jarak pagar (Jatropha curcas. L). Metode pembuatan biodiesel ini dengan transesterifikasi menggunakan katalis abu sabut kelapa dengan variasi berat sebanyak 2%, 4%, 5%, 6%, 8% dan 10% (b/b). Analisis kualitas dari biodiesel dilakukan dengan parameter mutu bilangan asam, bilangan iod, densitas, viskositas dan kadar air sesuai dengan standar SNI 04-7182-2006. Hasil penelitian menunjukkan bahwa kadar kalium dalam bentuk kalium karbonat dalam abu sabut kelapa sebesar 17,4% (b/b) dan konversi biodiesel yang diperoleh dari masing masing katalis berturut-turut adalah 43,62%; 78,45%; 76,22%; 75,69% dan 63,27% (b/b). Hasil optimum biodiesel diperoleh dengan penambahan katalis 4% dengan nilai densitas 0,86 (g/mL), nilai viskositas 3,23 (cSt), nilai kadar air 0,0352%, bilangan asam 0,12 (mg KOH/g) dan bilangan iod sebesar 8,23 (g I2/100 g). Kata kunci : Abu sabut kelapa, biodiesel, transesterifikasi, minyak biji jarak pagar(Jatropha curcas. L)
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Miles, Brittany E., Beth A. Biller, Polychronis Patapis, Kadin Worthen, Emily Rickman, Kielan K. W. Hoch, Andrew Skemer et al. "The JWST Early-release Science Program for Direct Observations of Exoplanetary Systems II: A 1 to 20 μm Spectrum of the Planetary-mass Companion VHS 1256–1257 b". Astrophysical Journal Letters 946, n.º 1 (1 de março de 2023): L6. http://dx.doi.org/10.3847/2041-8213/acb04a.
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Abstract We present the highest fidelity spectrum to date of a planetary-mass object. VHS 1256 b is a <20 M Jup widely separated (∼8″, a = 150 au), young, planetary-mass companion that shares photometric colors and spectroscopic features with the directly imaged exoplanets HR 8799c, d, and e. As an L-to-T transition object, VHS 1256 b exists along the region of the color–magnitude diagram where substellar atmospheres transition from cloudy to clear. We observed VHS 1256 b with JWST's NIRSpec IFU and MIRI MRS modes for coverage from 1 to 20 μm at resolutions of ∼1000–3700. Water, methane, carbon monoxide, carbon dioxide, sodium, and potassium are observed in several portions of the JWST spectrum based on comparisons from template brown dwarf spectra, molecular opacities, and atmospheric models. The spectral shape of VHS 1256 b is influenced by disequilibrium chemistry and clouds. We directly detect silicate clouds, the first such detection reported for a planetary-mass companion.
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Wild, Kathrin. "Morkötter, Steffi; Schmidt, Katja; Schröder-Sura, Anna (Hrsg.): Sprachenübergreifendes Lernen. Lebensweltliche und schulische Mehrsprachigkeit. Tübingen: Narr Francke Attempto, 2020. -- ISBN 978-3-8233-8247-8. 285 Seiten, € 58,00." Informationen Deutsch als Fremdsprache 49, n.º 2-3 (1 de abril de 2022): 233–36. http://dx.doi.org/10.1515/infodaf-2022-0040.
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