Bibliografias temáticas / 811/.6

Literatura científica selecionada sobre o tema "811/.6"

Autor: Grafiati
Publicado: 26 de julho de 2024

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Artigos de revistas sobre o assunto "811/.6"

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Schaeffer, Michael, Michaela Schneiderbauer, Sascha Weidler, Rosário Tavares, Markus Warmuth, Gabriele de Vos e Michael Hallek. "Signaling through a Novel Domain of gp130 Mediates Cell Proliferation and Activation of Hck and Erk Kinases". Molecular and Cellular Biology 21, n.º 23 (1 de dezembro de 2001): 8068–81. http://dx.doi.org/10.1128/mcb.21.23.8068-8081.2001.

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ABSTRACT Interleukin-6 (IL-6) induces the activation of the Src family kinase Hck, which is associated with the IL-6 receptor β-chain, gp130. Here we describe the identification of an “acidic” domain comprising amino acids 771 to 811 of gp130 as a binding region for Hck, which mediates proliferative signaling. The deletion of this region of gp130 (i.e., in deletion mutant d771-811) resulted in a significant reduction of Hck kinase activity and cell proliferation upon stimulation of gp130 compared to wild-type gp130. In addition, d771-811 disrupted the growth factor-stimulated activation of Erk and the dephosphorylation of Pyk2. Based on these findings, we propose a novel, acidic domain of gp130, which is responsible for the activation of Hck, Erk, and Pyk2 and signals cell proliferation upon growth factor stimulation.
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Chen, Heyin, Tove Ericson, Esko Kokkonen, Robert Temperton, Margit Andersson, Anastasiia Mikheenkova, William Brant e Maria Hahlin. "Investigating Surface Sensitivity of Ni-Rich Cathode Material Towards CO2 and H2O". ECS Meeting Abstracts MA2022-01, n.º 4 (7 de julho de 2022): 520. http://dx.doi.org/10.1149/ma2022-014520mtgabs.

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Layered Ni-rich transition metal oxide materials have been considered as the most promising cathode utilized in Li-ion batteries, e.g., LiNi0.8 Mn0.1 Co0.1 O2 (NMC 811). However, one of the drawbacks of NMC 811 is its high air sensitivity, leading to a degradation layer forming on the surface, and a lower cycling performance. Since the degradation mechanism is not fully understood, in this work, we use ambient pressure photoelectron spectroscopy (APPES)1 to investigate the surface sensitivity of NMC 811 towards CO2 and H2O in situ, aiming to determine the factor triggering the degradation. Before gas exposure, NMC 811 surface was Ar+ sputtered to remove the pre-existing boron oxide coating. The changes in surface chemical composition were monitored as a function of time and gas pressure. Results show that carbonate compounds are formed on the surface when NMC 811 is exposed to CO2. The carbonate compounds start to appear already within 2 minutes in CO2 at around 10-5 mbar. More interestingly, this reaction is reversed at around 3x10-6 mbar. Changes induced by water are slower, however, the water vapour effect on NMC 811 surface is irreversible. Results indicate that lithium hydroxide is formed, where Li+/H+ exchange on the surface is a possible route.2 Kokkonen, E.; Lopes Da Silva, F.; Mikkelã, M.-H.; Johansson, N.; Huang, S.-W.; Lee, J.-M.; Andersson, M.; Bartalesi, A.; Reinecke, B. N.; Handrup, K.; Tarawneh, H.; Sankari, R.; Knudsen, J.; Schnadt, J.; Såthe, C.; Urpelainen, S., Upgrade of the SPECIES beamline at the MAX IV Laboratory. Journal of Synchrotron Radiation 2021, 28 (2), 588-601. Hartmann, L.; Pritzl, D.; Beyer, H.; Gasteiger, H. A., Evidence for Li+/H+ Exchange during Ambient Storage of Ni-Rich Cathode Active Materials. Journal of The Electrochemical Society 2021, 168 (7), 070507. Figure 1
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Rousseau, Romain, Charlotte Labruyere, Charles Kajetanek, Olivia Deschamps, Konstantinos G. Makridis e Patrick Djian. "Complications After Anterior Cruciate Ligament Reconstruction and Their Relation to the Type of Graft: A Prospective Study of 958 Cases". American Journal of Sports Medicine 47, n.º 11 (12 de agosto de 2019): 2543–49. http://dx.doi.org/10.1177/0363546519867913.

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Background: Complications and adverse events after anterior cruciate ligament (ACL) reconstruction are well known, but they have been underestimated in previous studies. Purpose: To describe the complications and adverse events after ACL reconstruction within a 2-year follow-up and analyze them in relation to the type of graft. Study Design: Cohort study; Level of evidence, 3. Methods: From 2000 to 2012, 958 patients with an isolated ACL injury underwent surgery by a single knee surgeon. ACL reconstruction was performed with the medial portal technique for the femoral tunnel and the use of bone–patellar tendon–bone (BPTB) or hamstring tendon graft. Patients were reviewed at 6 weeks and 3, 6, 12, and 24 months after surgery with the International Knee Documentation Committee score, plain radiographs, and the KT-1000 arthrometer. Results: Of 958 patients enrolled, 147 (15%) were lost at last follow-up. The 2 groups (bone–patellar tendon–bone [n = 257] and hamstring [n = 554]) were similar regarding the mean age at the time of surgery and preoperative anterior laxity. The main complications were as follows: anterior knee pain (n = 130 of 811, 16%), stiffness (n = 72, 8.8%), secondary meniscal lesions (n = 59, 7.2%), pain attributed to fixation (n = 79, 9.7%), ACL rerupture (n = 47, 5.7%), contralateral ACL ruptures (n = 24, 3%), patellar fractures (n = 3, 0.3%), infections (n = 9, 1%), and thromboembolic complications (n = 5, 0.6%). There was no significant difference between the grafts with respect to the frequency of joint stiffness, secondary meniscal lesions, or anterior knee pain. During the first 2 postoperative years, the percentage of patients with anterior knee pain was higher in the patellar tendon group (23.3% vs 12.6%, P < .001); however, this difference was not significant after the 2-year interval (3.1% vs 2.5%, P = .63). The percentage of patients with a rerupture of the graft was significantly lower in the patellar tendon group than in the hamstring group (25 of 811 [3.1%] vs 57 of 811 [7%], P = .023). Similar results were recorded regarding the pain related to the hardware material (7 of 811 [0.8%] in the BPTB group vs 113 of 811 [13.9%] in the hamstring group, P = .001). The percentage of ACL ruptures contralateral to the repair was higher in the patellar tendon group (41 of 811 [5%] vs 17 of 811 [2%], P = .016). Conclusion: The total rate of complications after an ACL reconstruction was 39%, and the surgical revision rate for any reason was 28%. Problems with the hardware material were more frequent in the hamstring group, leading to an increased rate of surgical revision. Anterior knee pain was initially higher in the patellar tendon group, but there was no significant difference in a 2-year interval. The rerupture rate was statistically higher in the hamstring group.
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Martínez López, Ana Belén. "Peñaranda López, Antonio (2015). PROCESO PENAL COMPARADO (ESPAÑA, FRANCIA, INGLATERRA, ESTADOS UNIDOS, RUSIA). DESCRIPCIÓN Y TERMINOLOGÍA". Entreculturas. Revista de traducción y comunicación intercultural, n.º 7-8 (1 de janeiro de 2016): 969–71. http://dx.doi.org/10.24310/entreculturasertci.vi7-8.11498.

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La obra que aquí presento es la segunda edición corregida y aumentada de una monografía previa del mismo autor de 2011 titulada: El proceso penal en España, Francia, Inglaterra y Estados Unidos: descripción y terminología. Granada: Editorial Comares, colección interlingua nº 96 (1ª ed.). ISBN: 978-84-9836-811- 6.
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Durner, Edward F., e E. Barclay Poling. "Comparison of Three Methods for Determining the Floral or Vegetative Status of Strawberry Plants". Journal of the American Society for Horticultural Science 111, n.º 1 (janeiro de 1986): 158. http://dx.doi.org/10.21273/jashs.111.1.158.

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Abstract In the article “Comparison of Three Methods for Determining the Floral or Vegetative Status of Strawberry Plants” by Edward F. Dumer and E. Barclay Poling [Journal 110(6):808–811, Nov. 1985], the Fig. 2 caption was incorrect. The correct caption should read: Representative central longitudinal section of A. Questionable meristem (bar = 10 μ), B. Vegetative apex (bar = 10 μ), and C. Reproductive meristems (bar = 20 μ).
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Albino, Nicole, Clark T. Johnson, Ahizechukwu Eke e Linda Szymanski. "811: A retrospective assessment of delivery methods for breech singleton 22 - 26 6/7 week gestation". American Journal of Obstetrics and Gynecology 216, n.º 1 (janeiro de 2017): S465. http://dx.doi.org/10.1016/j.ajog.2016.11.544.

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Ho, H. S. S., M. Habicher, R. Neururer, H. Steiner, G. Bartsch e R. Peschel. "811 THE LEARNING CURVE OF ROBOTIC-ASSISTED LAPAROSCOPIC PARTIAL NEPHRECTOMY: A SINGLE CENTRE'S 6-YEARS EXPERIENCE". European Urology Supplements 8, n.º 4 (março de 2009): 323. http://dx.doi.org/10.1016/s1569-9056(09)60799-5.

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Pulido Acosta, Federico. "Diferencias por género en una validación de un instrumento para evaluar la felicidad en una muestra de estudiantes de secundaria". International Journal of Developmental and Educational Psychology. Revista INFAD de Psicología. 1, n.º 1 (3 de julho de 2019): 69. http://dx.doi.org/10.17060/ijodaep.2019.n1.v1.1386.

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Existe un enorme interés, dentro del ámbito educativo, por el campo de las emociones, ámbito que debe ser evaluado de manera adecuada. Por eso este trabajo tiene como objetivo validar un cuestionario para evaluar la Felicidad destinado a una muestra de alumnado de educación secundaria. Para esto se contó con una muestra de 811 participantes, procedentes de 6 centros distintos. Para evitar que la validez del instrumento se pueda ver negativamente afectada se aplicó en análisis a ambos géneros por separado. Para ello, se ha contado con 811 participantes, de seis IES en los que se imparte formación perteneciente a la Etapa Secundaria. Considerando la cultura, el grupo mayoritario es el de participantes pertenecientes a la cultura-religión musulmana. Estos constituyen el 71.6% de la muestra, mientras que el 28.4% de la misma pertenecía a la cultura-religión cristiana, siendo el 46.1% varones y el resto de la muestra (53.9%) mujeres. Como instrumento de evaluación se empleó un cuestionario elaborado para evaluar la felicidad. Los resultados obtenidos reflejan niveles de fiabilidad aceptables para ambos géneros ( de Cronbach de .897 en varones y de .908 en mujeres). Las dimensiones esperadas fueron diferentes (6 varones y 5 mujeres), apareciendo intercorrelaciones positivas entre los totales y las dimensione que lo conforman. Este cuestionario lo muestra como instrumento adecuado para evaluar estas capacidades en la población infantil-juvenil, tras realizar algunas modificaciones en trabajos futuros, siendo más indicado aplicar el análisis por separado.
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Hazell, Philip L., Michael R. Kohn, Ruth Dickson, Richard J. Walton, Renee E. Granger e Gregory W. van Wyk. "Core ADHD Symptom Improvement With Atomoxetine Versus Methylphenidate". Journal of Attention Disorders 15, n.º 8 (13 de setembro de 2010): 674–83. http://dx.doi.org/10.1177/1087054710379737.

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Objective: Previous studies comparing atomoxetine and methylphenidate to treat ADHD symptoms have been equivocal. This noninferiority meta-analysis compared core ADHD symptom response between atomoxetine and methylphenidate in children and adolescents. Method: Selection criteria included randomized, controlled design; duration 6 weeks; and assessment of ADHD Rating Scale–IV–Parent Version: Investigator Administered and Scored (ADHDRS) scores. Six-week response rates, defined as ≥40% reduction in ADHDRS total score, were compared using a noninferiority margin of −15%. Results: Seven studies met inclusion criteria ( N = 1,368). After 6 weeks, 53.6% (95% confidence interval [CI] 48.6%-58.4%) of atomoxetine-treated patients ( n = 811) had responded compared with 54.4% (47.6%-61.1%) for methylphenidate ( n = 557), with atomoxetine demonstrating noninferiority to methylphenidate (absolute difference −0.9%, 95% CI −9.2%-7.5%). Conclusion: After 6 weeks of treatment atomoxetine and methylphenidate had comparable efficacy in reducing core ADHD symptoms in children and adolescents.
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Ramalingam, J., M. S. Pathan, O. Feril, Miftahudin, K. Ross, X. F. Ma, A. A. Mahmoud et al. "Structural and functional analyses of the wheat genomes based on expressed sequence tags (ESTs) related to abiotic stresses". Genome 49, n.º 10 (outubro de 2006): 1324–40. http://dx.doi.org/10.1139/g06-094.

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To gain insights into the structure and function of the wheat (Triticum aestivum L.) genomes, we identified 278 ESTs related to abiotic stress (cold, heat, drought, salinity, and aluminum) from 7671 ESTs previously mapped to wheat chromosomes. Of the 278 abiotic stress related ESTs, 259 (811 loci) were assigned to chromosome deletion bins and analyzed for their distribution pattern among the 7 homoeologous chromosome groups. Distribution of abiotic stress related EST loci were not uniform throughout the different regions of the chromosomes of the 3 wheat genomes. Both the short and long arms of group 4 chromosomes showed a higher number of loci in their distal regions compared with proximal regions. Of the 811 loci, the number of mapped loci on the A, B, and D genomes were 258, 281, and 272, respectively. The highest number of abiotic stress related loci were found in homoeologous chromosome group 2 (142 loci) and the lowest number were found in group 6 (94 loci). When considering the genome-specific ESTs, the B genome showed the highest number of unique ESTs (7 loci), while none were found in the D genome. Similarly, considering homoeologous group-specific ESTs, group 2 showed the highest number with 16 unique ESTs (58 loci), followed by group 4 with 9 unique ESTs (33 loci). Many of the classified proteins fell into the biological process categories associated with metabolism, cell growth, and cell maintenance. Most of the mapped ESTs fell into the category of enzyme activity (28%), followed by binding activity (27%). Enzymes related to abiotic stress such as β-galactosidase, peroxidase, glutathione reductase, and trehalose-6-phosphate synthase were identified. The comparison of stress-responsive ESTs with genomic sequences of rice (Oryza sativa L.) chromosomes revealed the complexities of colinearity. This bin map provides insight into the structural and functional details of wheat genomic regions in relation to abiotic stress.
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Livros sobre o assunto "811/.6"

1

Nesi, Paolo, Jaime Delgado e Kia Ng, eds. AXMEDIS 2008. Florence: Firenze University Press, 2008. http://dx.doi.org/10.36253/978-88-8453-811-6.

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The AXMEDIS International Conference series aims to explore all subjects and topics related to cross-media and digital-media content production, processing, management, standards, representation, sharing, protection and rights management, to address the latest developments and future trends of the technologies and their applications, impacts and exploitation. The AXMEDIS events offer venues for exchanging concepts, requirements, prototypes, research ideas, and findings which could contribute to academic research and also benefit business and industrial communities. In the Internet as well as in the digital era, cross-media production and distribution represent key developments and innovations that are fostered by emergent technologies to ensure better value for money while optimising productivity and market coverage.
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2

By cold water: Poems. Detroit: Wayne State University Press, 2009.

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3

The art of daring: Risk, restlessness, imagination. Graywolf Press, 2014.

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4

SANTOS FILHO, J. A. Desoneração tributária das relações de trabalho: como fator de desenvolvimento sustentável e elemento de viabilização dos direitos sociais. Dialética, 2021. http://dx.doi.org/10.48021/978-65-5956-811-6.

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Senner, Nathan R., Yolanda E. Morbey e Brett K. Sandercock, eds. Flexibility in the Migration Strategies of Animals. Frontiers Media SA, 2020. http://dx.doi.org/10.3389/978-2-88963-811-6.

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Capítulos de livros sobre o assunto "811/.6"

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"6. The Bulgar Offensive, 811–814". In Byzantium and Bulgaria, 775-831, 217–64. BRILL, 2012. http://dx.doi.org/10.1163/9789004206960_008.

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"URLUS, JACQUES (9 JAN 1867–6 JULY 1935)". In Encyclopedia of Recorded Sound, 2241. Routledge, 2004. http://dx.doi.org/10.4324/9780203484272-811.

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Raymen, Thomas. "Chapter 6 The Parkour City". In Parkour, Deviance and Leisure in the Late-Capitalist City: An Ethnography, 101–23. Emerald Publishing Limited, 2018. http://dx.doi.org/10.1108/978-1-78743-811-820181006.

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Taber, Douglass. "Transition Metal-Mediated Ring Construction: The Yu Synthesis of 1-Desoxyhypnophilin". In Organic Synthesis. Oxford University Press, 2011. http://dx.doi.org/10.1093/oso/9780199764549.003.0075.

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Both 1 and 3 are inexpensive prochiral starting materials. Tae-Jong Kim of Kyungpook National University devised (Organomet. 2008, 27, 1026) a chiral Cu catalyst that efficiently converted 1 (other ring sizes worked as well) to the enantiomerically pure ester 2. Alexandre Alexakis of the University of Geneva found (Adv. Synth. Cat. 2008, 350, 1090) a chiral Cu catalyst that mediated the enantioselective coupling of 3 with Grignard reagents such as 4 . The π-allyl Pd complex derived from 6 is also prochiral. Barry M. Trost of Stanford University showed (Angew. Chem. Int. Ed. 2008, 47, 3759) that with appropriate ligand substitution, coupling with the phthalimide 7 proceeded to give 8, readily convertible to (-)-oseltamivir (Tamiflu) 9, in high ee. Jonathan W. Burton of the University of Oxford found (Chem Commun. 2008, 2559) that Mn(OAc)3 -mediated cyclization of 10 delivered the lactone 12 with high diastereocontrol. John Montgomery of the University of Michigan observed (Organic Lett. 2008, 10, 811) that the Ni-catalyzed cyclization of 12 also proceeded with high diastereocontrol. Ken Tanaka of the Tokyo University of Agriculture and Technology combined (Angew. Chem. Int. Ed. 2008, 47, 1312) Rh-catalyzed ene-yne cyclization of 14 with catalytic ortho C-H functionalization, leading to 16 in high ee. Eric N. Jacobsen of Harvard University designed (Angew. Chem. Int. Ed. 2008, 47, 1469) a chiral Cr catalyst for the intramolecular carbonyl ene reaction, that converted 17 to 18 in high ee. Using a stoichiometric prochiral Cr carbene complex 20 and the enantiomerically-pure secondary propargylic ether 19, Willam D. Wulff of Michigan State University prepared (J. Am. Chem. Soc. 2008, 130, 2898) a facially-selective Cr-complexed o -quinone methide intermediate, that cyclized to 21 with high ee. A variety of methods have been put forward for the transition metal-mediated construction of polycarbocyclic systems. One of the more powerful is the enantioselective Rh-catalyzed stitching of the simple substrate 22 into the tricycle 23 devised (J. Am. Chem. Soc. 2008, 130, 3451) by Takanori Shibata of Waseda University. Inter alia, ozonolysis of 23 delivered the cyclopentane 24 containing two all-carbon quaternary centers.
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Trabalhos de conferências sobre o assunto "811/.6"

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Георгиев, Павел. "Princeps Avarum and Cani Zauci in Aachen in the autumn of 811. Towards the Bulgarian-Frankish relations under the rules Krum (802?–814) and Omurtag (814–831)". In Hadak útján. A népvándorláskor kutatóinak XXIX. konferenciája. Budapest, 2019. november 15–16. 29th. Bölcsészettudományi Kutatóközpont Magyar Őstörténeti Kutatócsoport, 2022. http://dx.doi.org/10.55722/arpad.kiad.2021.4.1_10.

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The author offers new possibilities for interpretation of Frankish, domestic and Byzantine sources regarding the Bulgarian political control over territories of Avar Khaganate, destroyed by Charlemagne. The main focus is placed on the certificate of embassy led by Princeрs Avarum and Canizauci in Aachen in November 811. Coordinating it with Bulgarian and Byzantine sources, leads to the following conclusions. 1. It is likely that the diplomatic mission to Charlemagne in 811, involving representatives of the Avar com­munity, led by its Tudun and Slavic tribal princes, was led by the Bulgarian prince – Omurtag, the younger brother of the ruler Krum (802? – 814), in his capacity as prince (princeps) and ombritag. i. e. Avars hegem­on, in the northwestern borders after 803 and „Khan’s beloved younger brother” (khani sev`ingi or khani sev(inč) ingi). In Aachen, he introduced himself as a cani zautzi, that is, with his post of „Khan’s envoy”. 2. The khanas uvigi Omurtag (814–831) missions to Emperor Louis in 824 and 825–826 appear to have also been led by a member of the ruling family in Plisk oba (Pliska), maybe from his second son – Zvinitsa/Zvinichis. They also appear to have had a representative/s of settlers between 813 and 837 in Trans­Danubian Bulgaria (probably in the Lower Tisza region) of Bulgarian captives of Eastern Thrace of Armenian origin. One of their leaders in 837 was named Tzantzès, and his son, Stilian, and his descendants gained fame in Byzantium under the surname Ζαούτζης, Ζαούτζας. It coincides exactly with the pro­Bulgarian official title (position) zautzi (tzautci), (=chaush) and probably derived from it. On this basis, we conclude that Τζάντζην (Öан¤·þ воеводэ) was performing the carrier of messages or emissary functions of the Bulgarian state before 837. 3. The considered evidence, facts and circumstances surrounding the Bulgarian diplomatic missions of 811, 824 and 825/6 provide new testifies for the Bulgarian state’s control over the south-eastern parts of the Avar Khaganate after its collapse in the period 791–803. They have a contribution to clarify important aspects of the Bulgarian state’s relations with the East Frankish Kingdom, as well as with the local population of Avars, Bulgarians and Slavs there.
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Kanwar, Nisha, Pingzhao Hu, Mark Clemons, Philippe Bedard, David McCready e Susan J. Done. "Abstract 811: Identifying genomic signatures within circulating breast cancer cells." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-811.

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Тарасова, Т. С., Е. А. Пигарова, Л. К. Дзеранова, А. Н. Тюльпаков, Н. Н. Волеводз e И. И. Дедов. "МОЛЕКУЛЯРНО-ГЕНЕТИЧЕСКИЕ ОСОБЕННОСТИ СЕМЕЙНЫХ ФОРМ АДЕНОМ ГИПОФИЗА". In X (XXIX) НАЦИОНАЛЬНЫЙ КОНГРЕСС ЭНДОКРИНОЛОГОВ с международным участием «Персонализированная медицина и практическое здравоохранение». ФГБУ «НМИЦ эндокринологии» Минздрава России, 2023. http://dx.doi.org/10.14341/cong23-26.05.23-180.

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Распространённость аденом гипофиза в популяции высокая, агрессивное течение заболевания преимущественно наблюдается при семейных формах. Поиск новых генов, вовлечённых в процесс образования аденом гипофиза является важным фактором ранней диагностики моногенных заболеваний. В ГНЦ ФГБУ «НМИЦ эндокринологии» Минздрава России внедрены технологии высокопроизводительного параллельного секвенирования (Next generation sequencing, NGS) и разработана панель генов-кандидатов, включающая следующие 15 генов MEN1, CDKN1B, PRKAR1A, GNAS, AIP, SDHA, SDHB, SDHC, SDHD, PRKCA, CDKN2C, CDKN2A, POU1F1, PTTG2, DICER1. Задачей настоящего исследования стала оценка частоты мутаций в генах среди 36 пациентов с семейными формами аденом гипофиза. По результатам генетического тестирования методом NGS среди 36 представителей семей у 7 отмечены следующие изменения нуклеотидной последовательности: мутация в гене AIP:NM_003977.2:exon 5:c.783 C>G:p.Tyr261 у пациента с семейной соматотропиномой; мутация в гене AIP:NM_003977.2:exon 6: c.811 C>T:p. R271W у двух больных в семье с соматотропиномами; мутация в гене AIP:NM_003977.4:exon :c.649 С>Т:р. A411GfsX47 у двух лиц с семейными соматотропиномами/пролактиномами в одной семье; у одного пациента с семейной пролактиномой идентифицирована мутация в гене DICER1:NM_177438:exon 16:c.2553 G>A:p. Q851Q – синонимичная мутация – замена с недоказанным патологическим значением; у одного больного с семейной пролактиномой выявлено нарушение нуклеотидной последовательности в гене DICER1:NM_ 177438.2:exon 16: c.2613 C>A:p.D871E – несинонимичная замена с недоказанным патологическим значением; у одной пациентки с семейной тиреосоматотропиномой/соматотропиномой обнаружено изменение в гене DICER1:NM_177438:exon 2:c.20 A>G:p.Q7R – несинонимичная мутация и в гене SDHA:NM_004168:exon 8:c.1002 G>A:p.A334A – синонимичная мутация с недоказанным патологическим значением; мутация в гене GNAS: NM_080425:exon 1: c.314 A>G:p.E105G подтверждена у одного пробанда с синдромом МАS и семейной соматотропиномой. Частота мутаций в исследуемых 15 генах-кандидатов у пациентов с семейными формами аденом гипофиза составила 20% случаев, в 8% из которых идентифицированы изменения нуклеотидной последовательности в генах AIP и DICER1, в 3% – в генах SDHA и GNAS. Таким образом, применение метода высокопроизводительного параллельного секвенирования NGS, позволило предположить наличие крупных делеций в генах, сократило временные и материальные затраты на диагностику, что является предпочтительным для установления генетической природы заболевания лицам с семейными формами аденом гипофиза по сравнению с прямым секвенированием каждого гена в отдельности.
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Балашова, А. В., Л. В. Мачехина, Е. Н. Дудинская, И. Н. Стражеско e О. Н. Ткачева. "СОСТОЯНИЕ УГЛЕВОДНОГО ОБМЕНА У ДОЛГОЖИТЕЛЕЙ". In Сборник тезисов III Конференции по лечению и диагностике сахарного диабета «Фундаментальная и клиническая диабетология в 21 веке: от теории к практике». ФГБУ «НМИЦ эндокринологии» Минздрава России, 2023. http://dx.doi.org/10.14341/diaconfiii25-26.05.23-10.

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ЦЕЛЬ: оценить состояние углеводного обмена у долгожителей Москвы и близлежащих регионов. МАТЕРИАЛЫ И МЕТОДЫ: в это когортное исследование включались лица в возрасте 90 лет и старше, давшие письменное согласие на участие. В домашних условиях проводилась комплексная гериатрическая оценка, включавшая сбор анамнеза, применение стандартных гериатрических шкал и опросников, выполнение антропометрических измерений. Всем участникам оценивались следующие лабораторные показатели: глюкоза, инсулин, индекс инсулинорезистентности HOMA-IR, гликированный гемоглобин (HbA1c). Интерпретация состояния углеводного обмена проводилась согласно актуальным на 2022 г. клиническим рекомендациям. Статистический анализ данных проводился с помощью языка программирования R версии 4.1.3. Количественные переменные представлены в виде Me (Q1-Q3). Для сравнения непараметрических значений применялся критерий Краскела-Уоллиса, номинальных переменных – χ2 Пирсона или точный критерий Фишера. Исследование было одобрено локальным этическим комитетом. РЕЗУЛЬТАТЫ: за период с 2019 по 2022 г. в исследование было включено 3 811 человек (75,4% женщины) в возрасте 92 (91–94) года. Средний индекс массы тела составил 25,4 (23-28,2) кг/м2, доля участников с ожирением составила 15,2%, при этом у 72,9% пациентов были значения окружности талии соответствовали абдоминальному ожирению. Средние значения глюкозы составили 5 (4,5 – 5,7) ммоль/л, HbA1c 5,6 (5,4 – 5,9)%, HOMA-IR – 1,5 (0,9 – 2,6). В группу СД были отнесены 20,5% (780); предиабета – 16,1% (613). Все случаи СД были интерпретированы как 2 тип. В группе с СД большая часть пациентов 71,7% имела диагноз на основании данных анамнеза; у 28,3% пациентов были впервые выявлены значения параметров углеводного обмена в диабетическом диапазоне. С клинической точки зрения, значения показателей углеводного обмена в группе пациентов с СД были близки к значениям в группе предиабета: глюкоза - 6,3 (5,1 - 7,9) и 5,9 (5 - 6,4) ммоль/л, HbA1c 6,2 (5,6 - 7) и 6,1 (6 - 6,2)%, HOMA-IR 2,3 (1,3 - 6,1) и 2,2 (1,4 - 4,5), соответственно. При этом лишь 4,8% (38) участников с СД получали сахароснижающую терапию (ССТ): 3,8% (30) монтерапию инсулином, 0,6% (5) – терапию пероральными сахароснижающими препаратами, 0,4% (3) – комбинированную терапию. Несмотря на то, что в группе с впервые выявленным СД значения показателей углеводного обмена были статистически значимо выше, чем в группе с ранее выявленным СД (глюкоза 7,4 и 5,9 ммоль/л; HbA1c 6,8 и 6,1%, соответственно), они всё равно были ниже предполагаемых целевых значений для этой возрастной категории. Дополнительно пациенты были разделены на возрастные подгруппы: 90-94 лет (3091), 95-99 лет (674), >100 лет (46); достоверных различий в значениях показателей глюкозы и HbA1c, частоте СД и предиабета между группами получено не было. ВЫВОДЫ: доля пациентов с СД в исследованной когорте долгожителей была практически сопоставима с данными о распространённости СД в группе пожилых людей, при этом показатели углеводного обмена указывали на компенсацию углеводного обмена даже при низкой доле пациентов, получающих ССТ.
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Guan, Huaji, Fei Yan, Yufen Wang, Carter Battista, Xin Huang, Gary D. Stoner, Ronald G. Nines, Alexandria M. Edmonds e Tong Chen. "Abstract 811: Co-inhibition of cyclooxygenase-2 and inducible nitric oxide synthase prevents N-nitrosomethylbenzylamine-induced esophageal squamous cell carcinoma in rats". In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-811.

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