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Autor: Grafiati

Publicado: 23 de novembro de 2024

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Artigos de revistas sobre o assunto "620.116 92"

Masarova, Lucia, Naval Daver, Naveen Pemmaraju, Prithviraj Bose, Sherry Pierce, Taghi Manshouri, Jorge E. Cortes, Hagop M. Kantarjian e Srdan Verstovsek. "Do Patients with Post-Essential Thrombocythemia and Post-Polycythemia Vera Differ from Patients with Primary Myelofibrosis?" Blood 126, n.º 23 (3 de dezembro de 2015): 4069. http://dx.doi.org/10.1182/blood.v126.23.4069.4069.

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Abstract Introduction: Clinical characteristics of post-essential thrombocythemia/polycythemia vera myelofibrosis "post ET/PV-MF" are not well defined as for primary myelofibrosis "MF". Objective: We aimed to identify morphological, clinical and prognostic characteristics of patients with post ET/PV-MF seen at our center. Methods: Retrospective chart review of 1120 patients with MF - 766 primary MF, 354 post ET/PV-MF, who were referred to our institution between years 1984-2013 was performed; 92% presented after the year of 2000. Fisher's exact and Mann-Whitney test were used for categorical and continuous variables; Cox proportional hazard model and Kaplan-Meier curves with log rank test for correlation between the variables and survival. Survival analysis were calculated after censoring patients for stem cell transplantation "SCT" (n=92). Results: Overall median follow up was 36 months (0-411), 51% (n=573) patients had died. Progression to AML after median time of 32 months was not different between groups and occurred in 9.5% (n=106) patients over observation period of 5180 persons-years. Incidence rate was 3.4 cases per 100 persons-year. Causes of death were known in 55% of patients, and included progression of MF in 38% (n=122), infection in 27% (n=86), and other reasons with less than 10% occurrence (complications post SCT; secondary malignancy; other medical conditions). Demographics and disease characteristics are depicted in a table. 92% of patients were evaluable for karyotype; abnormalities were detected in 39% (n=404), of which 53% were unfavorable with monosomal (23%), complex (43%) and trisomy 8 (18%) being the most common. Molecularly high risk mutations "MHR" in genes ASXL1, EZH2, and IDH1/2 were positive in 35% of tested patients (n=161) regardless of presence of driver mutation. IPSS and DIPSS plus scores were similar between MF and post ET/PV-MF (with IPSS low in 8.7%, intermediate 1 in 19%, intermediate 2 in 28%, and high in 44%). By multivariate analysis, higher risk categories of IPSS and DIPSSplus predicted shorter overall survival "OS" for both cohorts (by DIPSSplus - high risk: HR 2.7, 95% CI 2.1-3.5; int-2: HR 1.6; 95% CI 1.3-2.0). Median OS stratified by IPSS was 160 (HR 1.8, 95%CI 1.0-3.0), 116 (HR 1.5, 95%CI 1.0 -1.5), 78 (HR 1.4, 95%CI 1.2-1.7) and 54 months, p=0.001. Univariate analysis identified age over 65, anemia, trombocytopenia, leukopenia, increased blasts, splenomegaly, constitutional symptoms, unfavorable karyotype, JAK2 mutation and triple negativity as predictors for inferior survival. Age over 65; hemoglobin below 10, platelets below 100 and peripheral blasts ≥1% showed significance for predicting OS by multivariate analysis. When stratified according to diagnosis, higher age, anemia, thrombocytopenia, high blasts, JAK2 positivity and triple negativity retained prognostic significance for MF whereas anemia, thrombocytopenia, and JAK2 mutation for post ET/PV-MF. Median OS was 73 months (range, 0.1-210) without difference between MF and post ET/PV-MF. Conclusion: Post ET/PV-MF does not appear to have substantial different clinical characteristics than primary MF. Table. Characteristics Total, number or median (% or range) MF, number or median (% or range) PET/PV-MF, number or median (% or range) Age 65 (20-89) 64 (20-88) 64 (27-89) Age > 65 552 (49) 367 (48) 185 (53) Males 675 (60%) 494 (65) 181 (51)* WBC 9.6 (0.4-361) 17.3 (5-19) 16.7 (5-18) WBC > 24 203 (18) 133 (18) 70 (20) WBC < 4 160 (14) 130 (17) 30 (8.5)* Plt 204 (3-2690) 237 (1-1364) 354 (6-2690)* Plt < 100 276 (25) 220 (29) 56 (16)* Hgb 10.5 (5-18) 10 (5-18) 11 (5-19)* Hgb < 10 462 (42) 329 (43) 133 (38)* Transfusion dependency 265 (24) 203 (27) 62 (18)* Blasts ≥ 1% 523 (47) 371 (49) 152 (43) Splenomegaly 668 (60) 459 (63) 209 (65) Symptoms 793 (71) 537 (70) 256 (73) LDH 1246 (189-10343) 1248 (189-10353) 1261 (205-8476) LDH > 620 958 (86) 640 (85) 318 (90)* JAK2 positive 586 (57) 371 (63) 215 (37)* MPL positive 19 (1.9) 16 (84) 3 (16)* CARL positive 53 (5) 27 (51) 26 (49)* Triple negative 26 (2.5) 21 (81) 5 (19)* *statistically significant differences (p<0.05) Disclosures Pemmaraju: Stemline: Research Funding; Incyte: Consultancy, Honoraria; Novartis: Consultancy, Honoraria, Research Funding; LFB: Consultancy, Honoraria. Cortes:Novartis: Consultancy, Research Funding; BMS: Consultancy, Research Funding; Teva: Consultancy, Research Funding; Pfizer: Consultancy, Research Funding; ARIAD Pharmaceuticals Inc.: Consultancy, Research Funding.

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Bekisheva, А., А. Makishev e А. Kukanova. "EXPERIENCE IN THE APPLICATION OF CASE-BASED LEARNING (CBL) IN THE CLASSES IN THE DISCIPLINE "ONCOLOGY"". Astana Medical Journal 2, n.º 116 (2023): 114–17. http://dx.doi.org/10.54500/2790-1203-2023-2-116-114-117.

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Currently, education in the higher medical school has changed significantly. There is a tendency to focus on student-centeredness and learning in an active format. The use of clinical cases based on specific situations that have taken place in clinical practice are called Case-based learning (CBL). The purpose of this message: Report results of application effectiveness of the use of CBL in students in the study of oncology. The innovative CBL method is used to conduct a practical lesson for students. In total, more than 50 CBL classes were conducted with more than 600 students in the discipline "Oncology". When compiling the CBL, real cases from clinical practice were selected. According to the classification, the case has the form of "small sketches" (short vignetts) on 8 pages. Classes by the case study method were carried out at practical classes on the topic "Cancer of the esophagus". Students' knowledge was assessed on a 100-point scale according to checklists that were developed in accordance with the content of the case. The average grade score of students before the introduction of CBL on the topic "Dysphagia" was 80.3 points. and after conducting classes with the use of CBL was 89.6, in the direction of improving performance in the tested groups by 9.3 points. The results of the feedback were evaluated according to three criteria: informative, visibility, accessibility for understanding, where all students participated. Informativе was rated as "excellent" - 82%, "good" - 18%.Visibility was rated as "excellent" - 85%, "good" - 15%. Accessibility for understanding was rated as "excellent" - 92%, "good" - 8%. Conclusions. CBL is an educational perspective in which students develop research potential, strategy and opportunities. Modeling professional situations through cases allows the student not only to solve the problem, but also to develop tactics of behavior in the proposed circumstances, predict the further development of the situation, determine the ability to work in a team, the ability to express their own views on the problem, conduct a discussion or debate.

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Murkamilov, Ilkhom T., K. A. Aitbaev e R. Kaliev. "Peculiarities of progression of chronic glomerulonephritis associated with anemia". Clinical Medicine (Russian Journal) 94, n.º 8 (3 de outubro de 2016): 620–23. http://dx.doi.org/10.18821/0023-2149-2016-94-8-620-623.

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Aim.To study the influence of renal anemia on the clinical course of chronic kidney disease in patients with chronic glomerulonephritis (CGN) at the early stage of the disease. Materials and methods. This prospective 12 month study included evaluation of clinical and laboratory characteristics of 149 patients aged 17-66 (mean 37,6±12,6) years at the pre-dialysis stage of CGN (92 men (37,04±13,4 yr) and 57 women (38,2±11,2 yr). Results. By the end ofprospective observation, patients of group 1 (CGN without anemia) showed a decrease of the hemoglobin level accompanied by the impairment of nitrogenreleasing function with the glomerular filtration rate of 70,1 (43,1-111) ml/min compared with 87 (61,3-115,3) at the onset of observations (p<0,05). In group 2 (CGN with anemia), dynamics of the nitrogen-releasing function was similar but even more pronounced with the glomerular filtration rate reduced to 47,4 (32,2-91,8) ml/mincompared with 80,7 (39,8-107,9) at the onset of observations (p<0,05) and the serum creatinine level increased to157 (92-242) mcmol/l compared with 123 (86-171) (p<0,05). Conclusion. Reduction of hemoglobin level in patients with CGN is apparent at the early stages of the disease in association with impairment of glomerular filtration. The data obtained indicate that anemia can be a laboratory predictor of deteriorated nitrogen-releasing function.

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Pereira, F. V., F. P. Lucena, R. L. Rodrigues, L. A. Barros, C. A. Pires, A. M. R. Ferreira e M. F. V. Mello. "Prevalência e distribuição espacial da ocorrência de helmintos em primatas não humanos de vida livre no estado do Rio de Janeiro, Brasil". Arquivo Brasileiro de Medicina Veterinária e Zootecnia 72, n.º 5 (setembro de 2020): 1705–12. http://dx.doi.org/10.1590/1678-4162-11868.

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RESUMO Seiscentos primatas neotropicais foram submetidos a exames post mortem para avaliação da prevalência parasitária de helmintos gastrointestinais. Foram examinados 556 calitriquídeos (Callithrix spp.), 23 bugios (Alouatta guariba), 19 macacos-pregos (Sapajus nigritus), um mico-leão-dourado (Leontopithecus rosalia) e um mico-leão-da-cara-dourada (Leontopithecus chrysomelas). Do total de 600 animais, foram encontrados espécimes parasitos pertencentes aos filos Acanthocephala, Nemathelmintes e Platyhelminthes (classes Trematoda e Cestoda) em 110 primatas. A prevalência de primatas positivos para, pelo menos, uma espécie de helminto foi de 18,3% (110/600), sendo destes 83,6% (92/110) calitriquídeos, 8,2% (9/110) bugios, 6,4% (7/110) macacos-pregos, 0,9% (1/110) mico-leão-dourado e 0,9% (1/110) mico-leão-da-cara dourada. Em 80,4% (74/92) dos calitriquídeos foram encontrados nematoides Primasubulura sp. e em 1,1% (1/92) nematoides Trypanoxyuris callithrix, em 26,1% (24/92) acantocéfalos (Pachysentis sp.) e em 5,4% (5/92) digenéticos (Platynosomum sp.); em 77,8% (7/9) dos bugios foram encontrados nematoides (Trypanoxyuris minutus), em 11,1% (1/9) acantocéfalos (Pachysentis sp.) e em 11,1% (1/9) cestoides (Bertiella sp.); em 14,3% (1/7) dos macacos-pregos foram encontrados nematoides (Physaloptera sp.), em 28,6% (2/7) acantocéfalos (Prostenorchis sp.) e em 14,3% (1/7) digenéticos (Platynosomum sp.) e no mico-leão-da-cara-dourada foram encontrados acantocéfalos (Prostenorchis sp.). Foi realizado o georreferenciamento dos pontos de encontro dos cadáveres para pontuar a distribuição dos helmintos por região.

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Shakira, Aisha, Ama Mullah, Abd Mujahid Hamdan e Syafrina Sari Lubis. "Efektivitas Metode Multi Soil Layering (MSL) dalam Penurunan Total Koliform Limbah Cair Domestik". Jurnal Dampak 20, n.º 2 (31 de julho de 2023): 83. http://dx.doi.org/10.25077/dampak.20.2.83-92.2023.

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This research employs Multi Soil Layering (MSL), an environmentally friendly technology, to remove coliform bacteria contaminants from wastewater using a novel alternative medium. The purpose of this study is to evaluate the efficacy of the MSL method employing bio rings in reducing pollutant parameters in domestic wastewater, particularly total coliform. This study utilized Hydraulic Loading Rate (HLR) variations of 23.80 L/m2/hour, 7.14 L/m2/hour, and 3.40 L/m2/hour, as well as Hydraulic Retention Time (HRT) variations of 4, 6, 8, 10, and 12 hours. The results of domestic wastewater treatment using the MSL method using HLR variations on total coliform from 1.89 105 MPN/100mL to 6.0 102 MPN/100mL, the total colony parameter from 5.95 106 CFU/mL to 3.6 105 CFU/mL, the chemical oxygen demand parameter value of 53 mg/L with an effectiveness of 98.6%, the total suspended solid parameter is valued at 25 mg/L with reduction effectiveness of 98.6% and the pH value changes to 7.3 at the HLR variation of 3.40 L/m2/hour. As for using the HRT variation for 12 hours the total coliform from 1.16 104 MPN/100mL to 9 102 MPN/100mL, the total colony parameter from 4.91 106 CFU/mL to 3.0 105 CFU/mL, the chemical oxygen demand parameter was 92 mg/L with its effectiveness 99%, the total suspended solid parameter is 87 mg/L with reduction effectiveness of 67% and the potential of hydrogen value changes to 7.6. Therefore, the MSL method employing bio rings can be used as a new option for domestic effluent treatment. Keywords: domestic wastewater, coliform total, Multi Soil Layering (MSL) ABSTRAK Penelitian ini menggunakan Multi Soil Layering (MSL), sebuah teknologi ramah lingkungan, untuk menghilangkan kontaminan bakteri coliform dari air limbah menggunakan media alternatif baru. Tujuan dari penelitian ini adalah untuk mengevaluasi efikasi metode MSL dengan bioring dalam menurunkan parameter polutan dalam air limbah domestik, khususnya total coliform. Penelitian ini memanfaatkan variasi Hydraulic Loading Rate (HLR) 23,80 L/m2/jam, 7,14 L/m2/jam, dan 3,40 L/m2/jam, serta variasi Hydraulic Retention Time (HRT) 4, 6, 8, 10, dan 12 jam. Hasil pengolahan air limbah domestik dengan metode MSL menggunakan variasi HLR pada total coliform dari 1,89 × 105 MPN/100mL menjadi 6,0 × 102 MPN/100 mL, parameter total koloni dari 5,95 × 106 CFU/mL menjadi 3,6 × 105 CFU/mL, nilai parameter kebutuhan oksigen kimia 53 mg/L dengan efektivitas 98,6%, parameter total padatan tersuspensi senilai 25 mg/L dengan efektivitas reduksi 98,6% dan nilai pH berubah menjadi 7,3 pada variasi HLR 3,40 L/m2/jam. Sedangkan untuk menggunakan variasi HRT selama 12 jam total coliform dari 1,16 × 104 MPN/100mL menjadi 9 × 102 MPN/100mL, parameter total koloni dari 4,91 × 106 CFU/mL menjadi 3,0 × 105 CFU/mL, kebutuhan oksigen kimia parameter 92 mg/L dengan efektivitas 99%, parameter total padatan tersuspensi 87 mg/L dengan efektivitas reduksi 67% dan nilai potensial hidrogen berubah menjadi 7,6. Oleh karena itu, metode MSL yang menggunakan bio ring dapat digunakan sebagai pilihan baru untuk pengolahan limbah rumah tangga. Kata kunci: air limbah domestik, total koliform, Multi Soil Layering (MSL)

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Krebs, John W., Jean S. Smith, Charles E. Rupprecht e James E. Childs. "Rabies surveillance in the United States during 1998". Journal of the American Veterinary Medical Association 215, n.º 12 (15 de dezembro de 1999): 1786–98. http://dx.doi.org/10.2460/javma.1999.215.12.1786.

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During 1998, 49 states, the District of Columbia, and Puerto Rico reported 7,961 cases of rabies in nonhuman animals and 1 case in a human being to the Centers for Disease Control and Prevention, a decrease of 6.5% from 8,509 cases in nonhuman animals and 4 cases in human beings reported in 1997. More than 92% (7,358 cases) were in wild animals, whereas > 7.5% (603 cases) were in domestic species (compared with 93% in wild animals and 7% in domestic species in 1997). Decreases were evident in all of the major contributing species groups, with the exception of skunks and bats. The relative contributions of the major groups to the total reported for 1998 were raccoons (44.0%; 3,502 cases), skunks (28.5%; 2,272), bats (12.5%; 992), foxes (5.5%; 435), cats (3.5%; 282), cattle (1.5%; 116), and dogs (11.5%; 113). No further discernable westward extension of the epizootic of rabies in raccoons in Ohio was reported. Twelve of the 19 states enzootic for the raccoon variant of the rabies virus and the District of Columbia reported decreased numbers of cases of rabies during 1998, compared with 13 states and the District of Columbia that reported increases during 1997. Three states, Rhode Island (143.2%), Massachusetts (77.2%), and New Hampshire (69.4%), reported increases of > 50% during 1998, compared with totals reported for 1997. In Texas, the number of cases of rabies associated with enzootic canine variants of the rabies virus remained greatly diminished; however, overall totals of reported cases of rabies increased in Texas and 12 other states where skunks are the major terrestrial reservoir of rabies. At the national level, the total of 82 reported cases of rabies among horses and mules was greater than that reported for any year since 1981 (88 cases) and represented a 74.5% increase, compared with the total for 1997. The 992 cases of rabies reported in bats during 1998 were the greatest proportionate contribution by bats since 1990. Reported cases of rabies in cats (282), dogs (113), and cattle (116) decreased 6.0%, 10.3%, and 4.9%, respectively. One indigenously acquired case of rabies reported in a human being during 1998 was the result of infection with a rabies virus variant associated with silver-haired and eastern pipistrelle bats.

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Fondevila, M., C. Castrillo, J. Gasa e J. A. Guada. "Rumen-undegradable dry matter and neutral detergent fibre as ratio indicators of digestibility in sheep given cereal straw-based diets". Journal of Agricultural Science 125, n.º 1 (agosto de 1995): 145–51. http://dx.doi.org/10.1017/s0021859600074591.

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SUMMARYStudies were conducted in 1989 at the University of Zaragoza, Spain, to determine the value of undegradable dry matter and neutral detergent fibre (uDM and uNDF) forestimating apparent dry matter digestibility (DMD), with sheep diets based on untreated or ammonia-treated barley straw (US or TS) offered alone or supplemented with 300 or 600 g/day of grass hay (H), barley (B) or sugarbeet pulp (P). Marker recovery in faeces was 107·9±1·90 and 96·4±1.43% for uDM and uNDF, respectively. Faecal uDM excretion was overestimated, especially with TS as sole feed and in B-supplemented diets (116%), whereas underestimation of uNDF excretion was observed mainly in unsupplemented US (92%), supplemented TS (92%) and in diets including H (91 %). Digestibility estimations from uDM or uNDF concentration in feeds and faeces (DuDM or DuNDF) were affected in the same way as DMD by the dietary sources of variation. Correlation coefficients between in vivo digestibility and its estimates with both internal markers were 0·80, and differences between DMD and DuDM and DuNDF were –2·5±0·14 and 2·2±0·13 percentage units, respectively. The suitability of both markers for predicting apparent digestibility, and the choice between them, would depend on diet characteristics.

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Seesaghur, Anouchka, Peter Egger, Joshua Warden, Ali Abbasi, Bethany Levick, Majid Riaz, Peter McMahon, Matthew Thompson e Sue Cheeseman. "Assessment of bone-targeting agents use in patients with bone metastasis from breast, lung or prostate cancer using structured and unstructured electronic health records from a regional UK-based hospital". BMJ Open 13, n.º 5 (maio de 2023): e069214. http://dx.doi.org/10.1136/bmjopen-2022-069214.

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ObjectiveTo assess use of bone-targeting agents (BTA) in patients with confirmed bone metastases (BM) from breast cancer (BC), non-small cell lung cancer (NSCLC) or prostate cancer (PC).DesignRetrospective cohort study.SettingRegional hospital-based oncology database of approximately 2 million patients in England.ParticipantsPatients aged ≥18 years with a diagnosis of BC, NSCLC or PC as well as BM between 1 January 2007 and 31 December 2018, with follow-up to 30 June 2020 or death; BM diagnosis ascertained from recorded medical codes and unstructured data using natural language processing (NLP).Main outcomes measuresInitiation or non-initiation of BTA following BM diagnosis, time from BM diagnosis to BTA initiation, time from first to last BTA, time from last BTA to death.ResultsThis study included 559 BC, 894 NSCLC and 1013 PC with BM; median age (Q1–Q3) was 65 (52–76), 69 (62–77) and 75 (62–77) years, respectively. NLP identified BM diagnosis from unstructured data for 92% patients with BC, 92% patients with NSCLC and 95% patients with PC. Among patients with BC, NSCLC and PC with BM, 47%, 87% and 88% did not receive a BTA, and 53%, 13% and 12% received at least one BTA, starting a median 65 (27–167), 60 (28–162) and 610 (295–980) days after BM, respectively. Median (Q1–Q3) duration of BTA treatment was 481 (188–816), 89 (49–195) and 115 (53–193) days for patients with BC, NSCLC and PC. For those with a death record, median time from last BTA to death was 54 (26–109) for BC, 38 (17–98) for NSCLC and 112 (44–218) days for PC.ConclusionIn this study identifying BM diagnosis from both structured and unstructured data, a high proportion of patients did not receive a BTA. Unstructured data provide new insights on the real-world use of BTA.

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Keene, David J., Joseph Alsousou, Paul Harrison, Heather M. O’Connor, Susan Wagland, Susan J. Dutton, Philippa Hulley, Sarah E. Lamb e Keith Willett. "Platelet-rich plasma injection for acute Achilles tendon rupture". Bone & Joint Journal 104-B, n.º 11 (1 de novembro de 2022): 1256–65. http://dx.doi.org/10.1302/0301-620x.104b11.bjj-2022-0653.r1.

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Aims To determine whether platelet-rich plasma (PRP) injection improves outcomes two years after acute Achilles tendon rupture. Methods A randomized multicentre two-arm parallel-group, participant- and assessor-blinded superiority trial was undertaken. Recruitment commenced on 28 July 2015 and two-year follow-up was completed in 21 October 2019. Participants were 230 adults aged 18 years and over, with acute Achilles tendon rupture managed with non-surgical treatment from 19 UK hospitals. Exclusions were insertion or musculotendinous junction injuries, major leg injury or deformity, diabetes, platelet or haematological disorder, medication with systemic corticosteroids, anticoagulation therapy treatment, and other contraindicating conditions. Participants were randomized via a central online system 1:1 to PRP or placebo injection. The main outcome measure was Achilles Tendon Rupture Score (ATRS) at two years via postal questionnaire. Other outcomes were pain, recovery goal attainment, and quality of life. Analysis was by intention-to-treat. Results A total of 230 participants were randomized, 114 to PRP and 116 to placebo. Two-year questionnaires were sent to 216 participants who completed a six-month questionnaire. Overall, 182/216 participants (84%) completed the two-year questionnaire. Participants were aged a mean of 46 years (SD 13.0) and 25% were female (57/230). The majority of participants received the allocated intervention (219/229, 96%). Mean ATRS scores at two years were 82.2 (SD 18.3) in the PRP group (n = 85) and 83.8 (SD 16.0) in the placebo group (n = 92). There was no evidence of a difference in the ATRS at two years (adjusted mean difference -0.752, 95% confidence interval -5.523 to 4.020; p = 0.757) or in other secondary outcomes, and there were no re-ruptures between 24 weeks and two years. Conclusion PRP injection did not improve patient-reported function or quality of life two years after acute Achilles tendon rupture compared with placebo. The evidence from this study indicates that PRP offers no patient benefit in the longer term for patients with acute Achilles tendon rupture. Cite this article: Bone Joint J 2022;104-B(11):1256–1265.

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VARGHESE, JOBIN, MATHEU PRESUME, KUZHICHALIL PEETHAMBHARAN SURENDRAN e MAILADIL THOMAS SEBASTIAN. "A NOVEL DIELECTRIC CERAMIC FOR MICROWAVE PASSIVE CIRCUITS". International Journal of Modern Physics: Conference Series 22 (janeiro de 2013): 153–58. http://dx.doi.org/10.1142/s2010194513010040.

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The tetragonal Ca 9 Nd 2 W 4 O 24 (CNW) ceramic was prepared by the conventional solid state ceramic route and their dielectric properties were investigated in the radio and microwave frequencies. The CNW ceramics sintered at 1450 °C for 4 h showed a densification 92 % with εr = 16 and tanδ = 0.004 at 15.1 GHz. The thermal conductivity of ceramic at room temperature was found to be 1.6 W m−1K−1 and coefficent of thermal expansion of CNW ceramics was 4.2 ppm/°C measured in the range of 25 to 600 °C. The dielectric and thermal properties of CNW ceramic are reported for the first time.

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Guatemala. Ley del impuesto sobre la renta: I.S.R. y su reglamento : Acuerdo gubernativo número 624-92, reformado Acuerdo gubernativo número 112-95, Decreto número 26-92, reformas Decreto número 61-94. Guatemala: [Congreso de la República], 1995.

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Kenyon, Michelle, John Murray, Barry Quinn, Diana Greenfield e Eugenia Trigoso. "Late Effects and Long-Term Follow-Up". In The European Blood and Marrow Transplantation Textbook for Nurses, 289–319. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-23394-4_15.

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AbstractAllogeneic stem cell transplantation was successfully performed in 1968, and its use has grown significantly over the past five decades with the total number now exceeding 1.5 million patients (Niederwieser et al. Haematologica. 107:1045–1053, 2022). HSCT is a curative treatment for many haematological cancers and other disorders. Almost 40,000 HSCT procedures are performed Europe-wide per annum (Passweg et al. Bone Marrow Transplant. 51(6):786–92, 2016), and the number of transplant recipients achieving ‘long-term survival’ and with late effects directly related to their treatment (Majhail et al. Hematol Oncol Stem Cell Ther 5(1):1–30, 2012) is increasing (Penack et al. Blood Adv 4:6283–6290, 2020). This growth in survivors is the result of improvements in transplant knowledge and expertise, refinements to conditioning regimes, developments in supportive care and increased numbers of procedures due to broadening transplant indications.The most common cause of death after transplant is relapsed disease. Yet, even without disease relapse, long-term survival is complex for many as other causes of mortality such as graft versus host disease (GvHD), infection, second malignancy, respiratory disease and cardiovascular disease (CVD) (Savani et al. Blood. 117:3002–9, 2011) prove difficult to address.Recovery post-HSCT is challenging, lasting several months to years. These individuals are susceptible to the development of post-treatment physical and psychological sequelae years to decades after completion of treatment leading to a reduced life expectancy with greater morbidity when compared to an age-adjusted population (Socié et al. N Engl J Med 341:14–21, 1999). Survivors with late effects experience significantly poorer physical and mental health, report more unmet needs for care and have significantly greater use of health services compared with survivors without late effects (Treanor et al. Psychooncology 22(11):2428–2435, 2013).Furthermore, as the number of survivors continues to grow, their long-term health problems and subsequent needs demand increasing resource and attention from late effects services. These services must remain agile and responsive, develop capacity to provide continuing expertise and oversight and collaborate with the other specialist services for input when needed.The unpredictable, complex and multifactorial nature of these long-term and late effects in HSCT survivors means that patients require regular life-long assessment guided by rigorous protocols. However, it is important to remember that even using standardised protocols, these should be different for adults and children and the resulting care must be tailored to the needs of the individual. And finally, further consideration is needed for the growing number of young people and adult survivors in long-term follow-up who have been treated in childhood and transitioned into adult long-term follow-up care.

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Öztürk, İzzet. "Türkiye’den KKTC’ye Su Temini Projesi’nde İklim Değişimi Etkileri". In İklim Değişikliği Çerçevesinde Kuzey Kıbrıs Türk Cumhuriyeti’nde Su Yönetimi, 43–58. Türkiye Bilimler Akademisi, 2024. http://dx.doi.org/10.53478/tuba.978-625-8352-92-4.ch02.

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A sea-crossing suspended water transmission pipeline (TRNC Water Supply) project has been developed for sustainable water transfer from Türkiye to the Cyprus Island in order to provide a permanent solution to the water problem in TRNC. The project, which has been completed in October 2015 had a total investment cost of 1.32 x 109 ₺ (480 x 106 $). The unit capitalized cost of the water with flowrate 75 x 106 m3/ year is calculated to be 0.6 $/m3, and the investment is expected to be repaid in 5.3 years. The aim of this study is to predict the impact of climate change scenarios on the water resources of the Eastern Mediterranean Watershed (supplying water from Dragon Creek to TRNC) of Türkiye by means of various simulations conducted for the projection period of 2015-2100. A regional climate model that is the output of 3 global models has been operated with RCP4.5 & RCP8.5 scenarios at the basin scale with a resolution of 10x10 km. Hydrologic models of SWAT and supporting WEAP models have been utilized to determine the variation of surface and groundwater resources based on the climate change projections. Hydrological Model Projections show that there may be a decrease of approximately 30-40% in the Blue Water Potential of the Eastern Mediterranean Basin, including the Dragon Stream, which supplies water from Türkiye to the TRNC during the 2015-2100 period. However, with the implementation of best practices related to adaptation to climate change, it is seen that there will not be any significant problem in the sustainability of 75 $ million m3/year water transfer from Dragon Stream to TRNC

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Stedman, Kenneth M., David Prangishvili e Wolfram Zillig. "Viruses of Archaea". In The Bacteriophages, 499–516. Oxford University PressNew York, NY, 2005. http://dx.doi.org/10.1093/oso/9780195148503.003.0031.

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Abstract Soon after these interesting discoveries, phage Mu revealed other fascinating aspects: (i) an unusual DNA structure consisting of heterogeneous host sequences at both ends of the Mu chromosome (27, 48, 49, 110), (ii) an ability to alternate host range by inversion of a DNA segment (127, 247), (iii) a paradigmatic mode of DNA replication by transposition, (iv) formation of a variety of host DNA rearrangements in the bacterial chromosome including inversions, duplications, and deletions of adjacent genes, replicon fusions, and transpositions of host DNA segments (57, 59, 60, 61, 160, 220, 241, 243), and (v) regulation, by DNA methylation, of the expression of the modification gene, mom (95, 96, 102, 119, 123, 205). As a transposon, Mu shows another unusual peculiarity: its ability to exploit two transposition mechanisms, replicative and nonreplicative, both of which are mediated by the same recombinase, the Mu transposase (the product of Mu gene A) (31). The Mu ability to promote genome rearrangements during its lytic cycle, in turn, was largely exploited in genetic manipulations for the construction of a large collection of bacterial strains, particularly in Ariane Toussaint and Malcolm Casadaban’s laboratories. As befitting an organism with such an important and varied life-style, there have been a number of previous reviews of Mu (153, 185), including a chapter in the previous edition of this book, published in 1988 (92), and even an entire book devoted to phage Mu, which was published in 1987 (235). Here we strive to bring the reader up to date on our understanding of biology of this fascinating virus.

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Theurl, Peter, e Anne Frey. "Bildungschancen erhöhen: Die Bedeutung außerschulischer Lernangebote für Lernerfolg und Motivation von Kindern und Jugendlichen am Beispiel der "Lerncafés"". In Grundschulforschung meets Kindheitsforschung reloaded, 284–95. Verlag Julius Klinkhardt, 2024. http://dx.doi.org/10.35468/6111-25.

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Die Lerncafés der Caritas sind eine Einrichtung, in der sozial benachteiligte Kinder und Jugendliche niederschwellig und kostenlos bei schulischen Anforderungen unterstützt werden, in der sie Motivation und Anerkennung finden und ein vorurteilsfreies und solidarisches Miteinander erleben. In einer wissenschaftlichen Begleitung der Lerncafés in Vorarlberg/Österreich wurde untersucht, ob sich bei Kindern und Jugendlichen, die ein Lerncafé besuchen, eine Verringerung der schulbezogenen Ängste, eine Verbesserung des Sozial- und Lernverhaltens feststellen lässt und wie die Lerncafés wahrgenommen werden und welche Wirkfaktoren für ihren Erfolg verantwortlich zeichnen. Die Datenerhebung erfolgte am Anfang der Schuljahre 2019/20 und 2020/21 (N = 119 Schüler:innen, 89 Eltern) und am Ende des Schuljahres 2020/21 (N = 92 Schüler:innen, 85 Eltern, 60 Betreuer:innen, 69 Lehrpersonen) mittels standardisierter Tests wie dem Angstfragebogen für Schüler und der Schülereinschätzliste für Sozial- und Lernverhalten sowie mit einem von den Autor:innen erstellten Fragebogen zur Einschätzung der Lerncafés. In der Untersuchung konnte gezeigt werden, dass die Lerncafés sozioökonomisch benachteiligten Schüler:innen, häufig mit Migrationshintergrund, einen kostenlosen Zugang zu außerschulischer Förderung bieten und dass sie dazu beitragen, Ängste zu reduzieren und Lern- und Sozialverhalten zu fördern. Die Unterstützung in schulischen und psychosozialen Belangen stellt eine hochwirksame Maßnahme dar, den Lernerfolg der Kinder und Jugendlichen zu erhöhen und Bildungsungerechtigkeiten zu reduzieren. (DIPF/Orig.)

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"Hockett TABLE 4 Broad and Narrow Sense Heritability and Genetic Advance Estimates for Grain Yield Components and Other Agronomic Characteristics Since 1964 Heritability" Broad sense Narrow sense Genetic advanceb Number Number Number Average Range references Average Range references Average Range references Characteristic (%) (%) reviewed (%) (%) reviewed (%) (%) reviewed Grain yield 44 5-93 26 27 0-54 11 23 3-46 10 Spike number 49 3-98 24 34 14-66 9 33 4-113 12 Kernels/spike 64 15-99 23 39 2-91 12 28 3-71 8 Kernel weight 63 24-99 22 43 13-78 10 12 2-22 9 Heading date 74 19-100 17 60 34-92 6 10 1-23 9 Lodging score 66 41-88 5 27 6-38 3 123 1 Plant height 66 4-99 30 41 8-73 13 15 1-44 11 Grain protein 53 5-98 14 32 8-76 4 16 5-22 3 Grain plumpness 62 34-90 5 43 24-58 3 18 11-24 2 Diastatic power Barley 82 55-94 5 58 23-94 3 20 Malt 68 50-86 2 Extract Barley 59 43-71 3 12 8-16 211 Malt 57 46-69 3 Spike length 66 3-98 17 50 44-56 5 20 4-34 8 'Computations were most often on the plot basis, but some were on a plant or trial mean basis. 'Given as percentage of the mean. Source: Ref. 15. barley [41] and have been used to produce homozygous sp. spontaneum and bulbosum have about 3000 and 600 lines and study segregation ratios and linkage values in ga-ascensions, respectively [46,47]. The locations of the ma-metes produced by F1 plants (haploids); produce aneu-jor base germplasm collections are shown in Table 5. ploids (triploids); and attempt to produce commercial, 2n = Working germplasm collections are found in Brazil, Bul-4x = 28 chromosome barleys (autotetraploids). Individual garia, the Czech Republic, England, Germany, Slovakia, pairs of barley chromosomes have been added to the chro-Syria, the Netherlands, the United States, and Russia [48]. mosome complement of wheat [41] and used to make ge-Many composite crosses of barley are maintained in the netic and evolutionary studies of barley. Figure 8 shows a United States, with CCXLVII being the last one assigned a micrograph of barley chromosomes. number by the USDA-ARS collection [49]. A new strategy to physically relate RFLP-based genetic Recent attempts have been made to set up "core" col-linkage maps with cytological markers of the barley chro-lections of barley germplasm [50,51]. Selection of these mosomes has been devised by Sorokin et al. [44]. Morpho-genotypes can be divided into four steps: (1) definition of logically distinct translocation chromosome were mi-domain, (2) division into genetically distinct types, (3) al-croisolated, and their DNA was used as a template for location of entries over types, and (4) choice of entries polymerase chain reaction with sequence-specific primers. [51]. Cross [50] has integrated both simply inherited phe-A recent review of these techniques in cereals is given by notypically obvious markers with electrophoretic patterns Kunzel and Korzun [45]. in setting up a core collection. D. Germplasm Resources 2. Wide Crosses Reviews describing the wide crosses made in barley are 1. Collections given by von Bothmer [47,52] and Fedak [53,54]. The ori-About 25,000 barley landraces plus 25,000 breeder lines gin, taxonomy, and related species of barley are described and cultivars are preserved in collections of barley [52], as are the incompatibility, mechanisms, and cytoge-throughout the world [46]. In addition, the wild H. vulgare netics of wild barley crosses [53]. There is a general lack". In Handbook of Cereal Science and Technology, Revised and Expanded, 104–10. CRC Press, 2000. http://dx.doi.org/10.1201/9781420027228-12.

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Trabalhos de conferências sobre o assunto "620.116 92"

Ceuca, S., A. Ferrara, S. Baietta, S. Campanari, P. Chiesa e Nicola Zecca. "Benchmarking Combined Cycle Power Plant Designs Employing 9-12%Cr CSEF Steels in Environments Prone to Steam Oxidation". In AM-EPRI 2019, editado por J. Shingledecker e M. Takeyama. ASM International, 2019. http://dx.doi.org/10.31399/asm.cp.am-epri-2019p0990.

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Abstract To stay competitive in today’s dynamic energy market, traditional thermal power plants must enhance efficiency, operate flexibly, and reduce greenhouse gas emissions. This creates challenges for material industries to provide solutions for harsh operating conditions and fluctuating loads. Higher efficiency demands steels with excellent steam oxidation resistance, favoring ferritic steels for cycling operation due to their limited thermal expansion. This paper presents a study modeling a combined cycle power plant using GE 9HA0.2 GT technology. The analysis compares different maximum live steam temperatures (585°C, 605°C, 620°C) and four alloys (grades 91 and 92, stainless S304H, and Thor 115) for heat exchangers exposed to steam oxidation. Results indicate that Thor 115, a creep strength enhanced ferritic (CSEF) steel, is a viable alternative to stainless steel for live steam temperatures above 600°C, offering improved oxidation resistance with minimal weight increase. Modern CSEF steels outperform stainless steel in power plants with lower capacity factors, reducing thermal fatigue during load changes. Increasing the live steam temperature boosts plant efficiency, leading to significant CO2 savings for the same power output.

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Beretta, Luiza de Lima, Arthur Costa Nascimento e Diogo Fernandes dos Santos. "Community-acquired pneumococcal meningoencephalitis associated with neurosyphilis in an immunocompetent patient: case report". In XIV Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2023. http://dx.doi.org/10.5327/1516-3180.141s1.482.

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Case report: A 28-year-old man with no comorbidities was admitted to our institution with a history of sudden holocranial headache, associated with fever, lowered level of consciousness and meningismus with the need for orotracheal intubation. Computed tomography of the brain was normal and the cerebrospinal fluid (CSF) on 05/28/2022 was yellowish, cloudy, glucose 6.0 mg/ dL, protein 752 mg/dL, cells 25,600 mm³ (neutrophils 92%, lymphocytes 5%), red blood cells 258 mm³, CSF Venereal Disease Research Laboratory (VDRL) 1/8, serum VDRL 1/32, treponemal test positive, human immunodeficiency virus (HIV) negative. Ceftriaxone, ampicillin, and acyclovir were empirically started. Pneumococcus was identified in the culture of CSF and blood cultures on admission and the antibiotic regimen was adequate, maintaining only ceftriaxone. Antibiotic therapy lasted 14 days, he was discharged after 16 days of hospitalization, for outpatient follow-up, with no neurological deficits. Control lumbar puncture on 12/23 revealed clear, colorless CSF, glucose 56 mg/dL, total protein 31.8 mg/dL, no cells or red blood cells, cultures negative. Discussion: Streptococcus pneumoniae is the most common cause of meningitis in adults, in older adults and in the current era, neurosyphilis, is most frequently seen in persons with HIV. There are no similar cases described in the literature. Despite the effectiveness of current antibiotics in clearing bacteria from the CSF, bacterial meningitis continues to cause significant morbidity and mortality worldwide. We describe a rare case of an immunocompetent patient with communityacquired pneumococcal meningoencephalitis associated with neurosyphilis treated with ceftriaxone who did not present sequelae or need for retreatment. Conclusion: It´s a rare cause of meningoencephalitis and has significant morbidity and mortality. More studies are needed regarding susceptibility to meningoencephalitis by multiple germs in immunocompetent patients.Case report: A 28-year-old man with no comorbidities was admitted to our institution with a history of sudden holocranial headache, associated with fever, lowered level of consciousness and meningismus with the need for orotracheal intubation. Computed tomography of the brain was normal and the cerebrospinal fluid (CSF) on 05/28/2022 was yellowish, cloudy, glucose 6.0 mg/ dL, protein 752 mg/dL, cells 25,600 mm³ (neutrophils 92%, lymphocytes 5%), red blood cells 258 mm³, CSF Venereal Disease Research Laboratory (VDRL) 1/8, serum VDRL 1/32, treponemal test positive, human immunodeficiency virus (HIV) negative. Ceftriaxone, ampicillin, and acyclovir were empirically started. Pneumococcus was identified in the culture of CSF and blood cultures on admission and the antibiotic regimen was adequate, maintaining only ceftriaxone. Antibiotic therapy lasted 14 days, he was discharged after 16 days of hospitalization, for outpatient follow-up, with no neurological deficits. Control lumbar puncture on 12/23 revealed clear, colorless CSF, glucose 56 mg/dL, total protein 31.8 mg/dL, no cells or red blood cells, cultures negative. Discussion: Streptococcus pneumoniae is the most common cause of meningitis in adults, in older adults and in the current era, neurosyphilis, is most frequently seen in persons with HIV. There are no similar cases described in the literature. Despite the effectiveness of current antibiotics in clearing bacteria from the CSF, bacterial meningitis continues to cause significant morbidity and mortality worldwide. We describe a rare case of an immunocompetent patient with communityacquired pneumococcal meningoencephalitis associated with neurosyphilis treated with ceftriaxone who did not present sequelae or need for retreatment. Conclusion: It´s a rare cause of meningoencephalitis and has significant morbidity and mortality. More studies are needed regarding susceptibility to meningoencephalitis by multiple germs in immunocompetent patients.

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Santos, RA, HFF Oliveira, MBS de Jesus, DS Doria e JAS Santos. "CORRELAÇÃO DAS VARIANTES DESCONHECIDAS EM HEMOGLONINAS GLICADAS COM IDENTIFICAÇÃO DE HBS NA ELETROFORESE DE HEMOGLOBINA EM UM LABORATÓRIO AMBULATORIAL EM SALVADOR". In Resumos do 55º Congresso Brasileiro de Patologia Clínica/Medicina Laboratorial, 11. Zeppelini Editorial e Comunicação, 2023. http://dx.doi.org/10.5327/1516-3180.141s2.7771.

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Objetivo: A anemia falciforme, expressão clínica da homozigose do gene da hemoglobina (Hb) S , é considerada a doença hereditária de maior prevalência no Brasil. Dados do Ministério da Saúde apontam que cerca de 3.500 crianças nascem com anemia falciforme por ano. Salvador concentra o maior número de portadores da doença: a cada grupo de 650 bebês nascidos vivos, um tem a patologia. Estima-se que, no mundo todo, existam 30 milhões de heterozigotos e, no Brasil, esse número provavelmente situa-se próximo de dois milhões. O objetivo deste trabalho foi avaliar a população atendida no nosso serviço que realizou o exame de Hb glicada e apresentou Hb variante desconhecida, correlacionando com a presença de Hb S na eletroforese de Hb. Método: Foi realizada uma análise retrospectiva dos resultados do exame Hb glicada de 7.644 pacientes, no período de janeiro a maio de 2023. Conclusão: O estudo demonstrou que do total de pacientes que realizaram Hb glicada no período, 445 apresentaram Hb variante (6%); 320, Hb variante desconhecida (72%) e apenas 25 realizaram o exame eletroforese de Hb – sendo 24 pacientes apresentando Hb S. Os pacientes que apresentaram Hb S na eletroforese de Hb eram heterozigotos (traço falciforme); 92% dos indivíduos que apresentaram variante desconhecida não realizaram o exame eletroforese de Hb e podem não ter conhecimento do traço falciforme. Desses pacientes, 24% estavam na faixa etária reprodutiva (18 a 40 anos), o que aumenta a chance de gerar crianças homozigotas, as quais podem desenvolver a forma grave da doença falciforme. Concluiu-se que existe ainda a necessidade da divulação maciça da importância de se realizar exames, principalmente no nosso estado, para identificação de indivíduos heterozigotos. Além disso, há a necessidade de programas comunitários de diagnóstico precoce da doença falciforme para investigação de sujeitos Hb S heterozigotos, bem como o aconselhamento genético não diretivo dos casais de heterozigotos com o traço falciforme.

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Силкина, М. И., Н. А. Белякова, М. Б. Лясникова e С. С. Рубина. "НАРУШЕНИЯ УГЛЕВОДНОГО ОБМЕНА И СИНДРОМ ОБСТРУКТИВНОГО АПНОЭ СНА ПРИ ОЖИРЕНИИ". In X (XXIX) НАЦИОНАЛЬНЫЙ КОНГРЕСС ЭНДОКРИНОЛОГОВ с международным участием «Персонализированная медицина и практическое здравоохранение». ФГБУ «НМИЦ эндокринологии» Минздрава России, 2023. http://dx.doi.org/10.14341/cong23-26.05.23-160.

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ЦЕЛЬ: изучить частоту различных нарушений углеводного обмена и их взаимосвязь с синдромом об- структивного апноэ сна (СОАС) при алиментарно-конституциональном ожирении (АКО). МАТЕРИАЛЫ И МЕТОДЫ: у 76 пациентов (38 мужчин и 38 женщин) с АКО в возрасте 30-60 лет проведе- но общеклиническое обследование, включающее измерение артериального давления (АД), антропометрию (индекс массы тела - ИМТ, кг/м2 и окружность талии - ОТ, см), лабораторное исследование (холестерин, глюкоза, инсулин с расчётом инсулинорезистентности (ИР)), полисомнографию с определением: степени тяжести СОАС по индексу апноэ/гипопноэ (ИАГ: норма: < 5/ч, легкая степень: 5−14/ч, средняя степень тяжести: 15−30/ч, тяжелая: >30/ч.), минимальной сатурации за время сна (SPmin: N 90−96%), времени са- турации во сне менее 90% (TSPcrit, сек), максимальной продолжительности апноэ за время исследования (Tmax, сек), индекса десатурации (ИД/ч). Статистический анализ выполнен с использованием программного комплекса Statistica 12. РЕЗУЛЬТАТЫ: нарушения углеводного обмена имели 36 (47,4%) обследованных с АКО. В зависимости от этого были сформированы три группы: 1-я – 13 (17,1%) пациентов с сахарным диабетом 2 типа (СД2) (возраст - 54 [38; 62] года, средний уровень гликемии натощак 8,1±1,6 ммоль/л), 2-я – 23 (30,3%) боль- ных с нарушенной толерантностью к глюкозе (НТГ) (54 [48; 63] года, 6,9±1,2 ммоль/л) и 3-я – 40 (52,6%) человек без нарушений углеводного обмена (50 [44; 57] лет, 5,1±1,5 ммоль/л). В 1-й группе средний ИМТ составил 40,8±6,0 кг/м2, ОТ - 123,6±11,9 см, во 2-й – соответственно 41,7±6,1 кг/м2 и 125,2±16,1 см и в 3-й – 39,3±7,3 кг/м2 и 124,4±18,7 см. Средние показатели систолического АД соответствовали в 1-й и 2-й группах АГ 1-й степени, а в 3-й группе - нормальному повышенному АД, также, как и диастолическое АД во всех группах. ИР по индексу HOMA (>2,55) была диагностирована у большинства обследованных 1–й и 2-й групп (61,5% и 78,3% против 47,5% в 3-й, χ2=5,7; р<0,05). В липидном профиле уровень общего холестерина был повышен соответственно в 38,5%, 47,8% и 40% случаев, без достоверных различий. СОАС был диагности- рован у 92% обследованных, при этом в 1-й группе – в 92,3%, во 2-й – в 65,2% - и в 3-й – в 67,5% случаев. Средний ИАГ в 1-й и 2-й группах соответствовал СОАС тяжелой степени тяжести (31 [10; 77] и 46 [15; 69]), а в 3-й – средней (17 [10; 47]; р<0,05). Минимальная сатурация за время сна во всех группах была снижена без достоверных различий. Все остальные показатели: SPmin, TSPcrit, Tmax, ИД/ч были выше во 2-й группе по сравнению с 1-й и 3-й (р2,3<0,05). ВЫВОДЫ: таким образом, среди обследованных пациентов с ожирением, в основном III степени, и аб- доминальным типом половина имеют нарушения углеводного обмена. Не зависимо от этого у большинства больных отмечается СОАС, который в большей степени связан со степенью и типом ожирения, а также инсулинорезистентностью. Наиболее выраженные нарушения всех показателей полисомнографии на- блюдаются при НТГ на фоне ожирения и АГ 1 степени.

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