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Mudriczki, Judit. "New Hungarian Narratives in the History of English Literature". Eger Journal of English Studies 21 (2023): 111–14. http://dx.doi.org/10.33035/egerjes.2023.21.111.
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Review. Az angol irodalom története. Vol. I. A középkor. [‘History of English Literature. Vol. I. The Middle Ages.’] Edited by Tamás Karáth and Katalin Halácsy. Editors in chief: Tamás Bényei and Géza Kállay. Budapest: Kijárat, 2020. Pp. 411. ISBN 978-615-5160-77-6., Az angol irodalom története. Vol. II. A kora újkor. [‘History of English Literature. Vol. II. The Early Modern Period.’] Edited by Attila Atilla Kiss and György Endre Szőnyi. Editors in chief: Tamás Bényei and Géza Kállay. Budapest: Kijárat, 2020. Pp. 501. ISBN 978-615-5160-78-3.
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Rola, Alda Cunha, Helen Kalirai, Azzam F. G. Taktak, Antonio Eleuteri, Yamini Krishna, Rumana Hussain, Heinrich Heimann e Sarah E. Coupland. "A Retrospective Analysis of 10 Years of Liver Surveillance Undertaken in Uveal Melanoma Patients Treated at the Supraregional “Liverpool Ocular Oncology Centre”, UK". Cancers 14, n.º 9 (27 de abril de 2022): 2187. http://dx.doi.org/10.3390/cancers14092187.
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Purpose: To determine liver screening frequency and modality in UM patients following primary treatment, and the characteristics of detected metastases. Methods: A 10-year retrospective study of 615 UM patients undergoing liver surveillance in Liverpool. Information was collected from liver scan reports of these patients. Results: Of 615 UM patients analyzed, there were 337 men (55%) and 278 women (45%). Median age at primary treatment was 61 years (range, 22–94). At study end, median follow-up was 5.1 years, with 375 patients (61%) alive and 240 deceased (39%). Of the deceased patients, 187 (78%) died due to metastatic UM; 24 (10%) deaths were due to other causes; and 29 (12%) patients died of unknown conditions. In total, 3854 liver scans were performed in the 615 UM patients, with a median of 6.2 scans per patient (range, 1–40). Liver MRI was most frequently performed (62.8%). In total, 229 (37%) UM patients developed metastases during the study period: 150 were detected via liver surveillance and 79 were observed post-mortem. Conclusions: Metastatic UM onset is related to the size and genetic profiles of the primary UM, and can be predicted using the model LUMPO3. Regular liver surveillance allowed for timely detection of metastases, and through metastasectomy can lead to prolongation of life in some patients.
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Linden, Kelly, Sarah Teakel e Neil Van der Ploeg. "Improving Student Success with Online Embedded Tutor Support in First-Year Subjects". Student Success 13, n.º 2 (6 de julho de 2022): 42–50. http://dx.doi.org/10.5204/ssj.2338.
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Institutional commitment to the student experience in the early stages of university has the greatest potential to exceed student expectations. The cross-institutional Embedded Tutors Program provides undergraduate students with access to subject content experts from 12 first-year subjects across a regional university. Tutors provide one-on-one draft assessment feedback in subjects with a large written assessment task. A total of 428 students attended 615 tutor sessions held online via Zoom. Students who met with a tutor had higher average assessment marks and cumulative subject marks than those students who did not attend a session. Feedback from students was positive, with 78% of students rating the tutor session “extremely helpful.” This study provides evidence of the value of subject-specific draft assessment feedback for students in first-year subjects.
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Liu, Qing Sheng, Hai Feng Tang e Hui Fang. "Upgrade Silicon Powder Prepared by SHS with Acid Leaching Treatment". Advanced Materials Research 402 (novembro de 2011): 312–15. http://dx.doi.org/10.4028/www.scientific.net/amr.402.312.
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Upgrade silicon powder have been prepared by a two-stage technique consisting of a self-propagating high-temperature synthesis (SHS) process in a SiO2+Mg system in an inert atmosphere and the hydrometallurgical treatment of the combustion product. It was found from DTA curve that the initial starting temperature(Tin) of the reaction was 615°C. The adiabatic temperature (Tad) of system was calculated under the different molar ratios of Mg/SiO2 and the results showed the reaction would happen and be kept by the self-propagating way only when the excess coefficient(x) of Mg was more than 0.9. The value of Tad would increase with the increasing of x. XRD Pattern indicated MgO2 and element Si were main phases in combustion products except a little matter MgSi2O4. The purity of the combustion-synthesized Si samples was greater than 99.98% after the acid leaching treatment, and the experimental yield of the powder was approximately 78%.
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Fattal, B., E. Peleg-Olevsky, Y. Yoshpe-Purer e H. I. Shuval. "The Association Between Morbidity among Bathers and Microbial Quality of Seawater". Water Science and Technology 18, n.º 11 (1 de novembro de 1986): 59–69. http://dx.doi.org/10.2166/wst.1986.0142.
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During the summer of 1983, a prospective epidemiological study was carried out at three coastal beaches in the area of Tel-Aviv, Israel, in order to investigate the effect of marine pollution on morbidity among bathers. A total of 615 families comprising 2 231 persons, 23% of them aged 0–4 years, were interviewed for this study. A total of 78 seawater samples were laboratory tested on the day of collection for the concentration of six bacterial indicators: fecal coliforms, fecal streptococci, enterococci, E.coli, Staphylococcusaureus and Pseudomonas aeruginosa. The geometric mean of the fecal coliforms was the highest at all beaches, and the concentration of pseudomonas the lowest. All beaches complied with Israel Ministry of Health, bacterial standards for bathing beaches and were within the WHO/UNEP guidelines for fecal coliforms. However, analysis of the results indicated that symptoms of enteric morbidity among swimmers,particularly in the 0–4 year old age group, were related to “high” density levels of enterococci, E.coli and staphylococci. Also, swimmers had more morbidity symptoms of all types (“enteric”,“respiratory” and “others”) than nonswimmers, regardless of the microbial quality of seawater.
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Bajraktari, Artan, Ibadete Bytyçi e Michael Y. Henein. "High Coronary Wall Shear Stress Worsens Plaque Vulnerability: A Systematic Review and Meta-Analysis". Angiology 72, n.º 8 (4 de fevereiro de 2021): 706–14. http://dx.doi.org/10.1177/0003319721991722.
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Aim: The aim of this meta-analysis is to assess the impact of wall shear stress (WSS) severity on arterial plaque vulnerability. Methods: We systematically searched electronic databases and selected studies which assessed the relationship between WSS measured by intravascular ultrasound and coronary artery plaque features. In 7 studies, a total of 615 patients with 28 276 arterial segments (median follow-up: 7.71 months) were identified. At follow-up, the pooled analysis showed high WSS to be associated with regression of plaque fibrous area, weighted mean difference (WMD) −0.11 (95% CI: −0.20 to −0.02, P = .02) and fibrofatty area, WMD −0.09 (95% CI: −0.17 to −0.01, P = .02), reduction in plaque total area, WMD −0.09 (95% CI: −0.14 to −0.04, P = .007) and increased necrotic core area, and WMD 0.04 (95% CI: 0.01-0.09, P = .03) compared with low WSS. Dense calcium deposits remained unchanged in high and low WSS (0.01 vs 0.02 mm2; P > .05). High WSS resulted in profound remodeling (40% vs 18%, P < .05) and with more constructive remodeling than low WSS (78% vs 40%, P < .01). Conclusions: High WSS in coronary arteries is associated with worsening plaque vulnerability and more profound arterial wall remodeling compared with low WSS.
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Hariprasad, Roopa, Sonam Tulsyan, Roshani Babu, Kavitha Dhanasekaran, Nisha Thakur, Showket Hussain, Richa Tripathi et al. "Evaluation of a Chip-Based, Point-of-Care, Portable, Real-Time Micro PCR Analyzer for the Detection of High-Risk Human Papillomavirus in Uterine Cervix in India". JCO Global Oncology, n.º 6 (setembro de 2020): 1147–54. http://dx.doi.org/10.1200/go.20.00024.
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PURPOSE Currently available human papillomavirus (HPV) detection devices are expensive, requiring a continuous power supply, high-priced reagents, skilled laboratory personnel, and infrastructure. These make it difficult to implement primary HPV screening in high-risk (HR) populations, particularly in low-income settings such as in India. The objective of our study was to evaluate the diagnostic performance of a point-of-care, portable, battery-operated device called Truenat, which detects 4 HR HPV genotypes (16, 18, 31, and 45), as a potentially cost-effective alternative to conventional HPV diagnostic tests. PATIENTS AND METHODS This was a single-site, blinded, cross-sectional study that evaluated the performance of the Trunat HPV-HR using cervical samples collected from nonpregnant women > 30 years old via consecutive sampling. The comparison was conducted against the Hybrid Capture 2 (HC2) method. All the positive samples were validated by 14 Real-TM Quant Kit. RESULTS Of 615 cervical samples, the HR-HPV DNA test was positive in 78 women (12.7%) by HC2 and in 49 (8%) by Truenat. With the consideration of limited genotype inclusivity, the sensitivity and specificity of Truenat HPV-HR were 97.7% and 98.9%, respectively. CONCLUSION The performance of Truenat HPV-HR test was comparable to that of HC2 in the 4 HPV genotypes and would be appropriate to consider for use in primary HR cervical cancer screening and particularly in low-income settings.
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Bei, Roslina Boba Bei Boba, Andreas Ariyanto Rangga e Maria Wilda Malo. "SISTEM PENDUKUNG KEPUTUSAN PENENTUAN PENERIMA BANTUAN LANGSUNG TUNAI DESA TEBARA MENGGUNAKAN METODE SAW". Jurnal Intra Tech 7, n.º 2 (31 de outubro de 2023): 30–43. http://dx.doi.org/10.37030/jit.v7i2.149.
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Desa Tebara merupakan salah satu dari 13 desa yang berada di wilayah administrasi Kecamatan Kota Waikabubak, Kabupaten Sumba Barat, Nusa Tenggara Timur. Jumlah penduduk di Desa Tebara sampai dengan bulan Desember 2022 adalah sebanyak 2.758 jiwa yang terdiri dari 1.355 laki-laki dan 1.384 perempuan. Dari 6 (enam) dusun di Desa Tebara, dusun 1 memiliki 101 KK , dusun 2 memiliki 106 KK, dusun 3 memiliki 131 KK, dusun 4 memiliki 147 KK, dusun 5 memiliki 78 KK, dan dusun 6 memiliki 52 KK. Dan total KK dari 6 (enam) dusun tersebut yaitu 615 KK. Secara garis besar mayoritas penduduk desa tebara bekerja sebagai petani. Berdasarkan informasi yang diperoleh terdapat 157 orang penerima BLT di desa tebara. Adapun kriteria penerima BLT di Desa Tebara yaitu jumlah penghasilan, status perkawinan, jumlah anak, umur dan pekerjaan. Tujuan dari perancangan dan pembuatan Sistem Pendukung Keputusan Penentuan Bantuan Langsuang Tunai ini adalah untuk membantu Desa Sidomulyo dalam penerimaan bantuan. Dalam Sistem pendukung Keputusan penentuan Bantuan Langsung Tunai ada beberapa kriteria dan alternatif yang digunakan untuk menentukan bantuan langsung tunai. Kriteria yang digunakan adalah : Pekerjaan, Umur, Jumlah Tanggungan, Penghasilan dan Pengeluaran. Sedangkan alternatifnya adalah semua orang yang terdata dalam data penerima bantuan langsung tunai di desa Tebara. Hasil dari penelitian ini berupa Aplikasi Penentuan Bantuan Langsung Tunai yang membantu desa Tebara dalam menentukan penerima bantuan
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Vodicka, Josef, Martin Pesta, Vlastimil Kulda, Katerina Houfkova, Bohuslava Vankova, Jakub Sebek, Martin Skala, Jakub Fichtl, Kristyna Prochazkova e Ondrej Topolcan. "Prognostic Significance of Lymph Node Examination by the OSNA Method in Lung Cancer Patients—Comparison with the Standard Histopathological Procedure". Cells 9, n.º 12 (4 de dezembro de 2020): 2611. http://dx.doi.org/10.3390/cells9122611.
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The aim of the study was to compare the prognostic significance of lymph node status of patients with lung cancer analyzed by three different methods: hematoxylin and eosin (H&E), immunohistochemistry of cytokeratin 19 (IHC CK19), and One-Step Nucleic Acid Amplification (OSNA). The clinical relevance of the results was evaluated based on relation to prognosis; the disease-free interval (DFI) and overall survival (OS) were analyzed. During radical surgical treatment, a total of 1426 lymph nodes were obtained from 100 patients, creating 472 groups of nodes (4–5 groups per patient) and examined by H&E, IHC CK19 and OSNA. The median follow-up was 44 months. Concordant results on the lymph node status of the H&E, IHC CK19 and OSNA examinations were reported in 78% of patients. We recorded shorter OS in patients with positive results provided by both OSNA and H&E. The study demonstrated a higher percentage of detected micrometastases in lymph nodes by the OSNA method. However, the higher sensitivity of the OSNA, with the cut-off value 250 copies of mRNA of CK19/µL, resulted in a lower association of OSNA positivity with progress of the disease compared to H&E. Increasing the cut-off to 615 copies resulted in an increase in concordance between the OSNA and H&E, which means that the higher cut-off is more relevant in the case of lung tumors.
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Singh, Rohit, Adrian Chojnowski e Stuart Hay. "Hand and Wrist Injuries Related to Motocross Injuries: 5 Year Series". Journal of Hand Surgery (Asian-Pacific Volume) 24, n.º 01 (13 de fevereiro de 2019): 60–64. http://dx.doi.org/10.1142/s2424835519500115.
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Background: The increasingly fashionable sport of motocross is practiced worldwide by millions of people, but there is very little in the literature regarding its associated injuries and their prevention. We therefore present the first comprehensive, prospective study looking at hand and wrist injuries resulting from motocross injuries in the UK. Methods: Data was prospectively collected over a 5-year period (from 2010 to 2015) at our regional trauma unit. We exclusively looked at motocross riders. Injuries sustained via motorcycle were excluded from our study. Results: During the period studied (five years), 615 injuries were collected, including 240 patients with 265 hand and wrist injuries. Most of injuries were sustained in male patients. The patient’s age range was from 4–78 years with most injuries occurring during the spring and summer months. A total of 96 (40%) patients required operative treatment. The most common injury pattern was distal radius fractures (n = 53, 20%), followed by metacarpal fractures (n = 38, 14%) and phalangeal fractures (n = 36, 13.5%). Conclusions: This study shows the impact and incidence of related hand and wrist injuries. Motocross is a globally fashionable sport. This study shows that the number of annual tournaments and racers have doubled in last 5 years. The number of hand and wrist related injuries and operative requirements have quadruples over the last five years. It is recognized as a high-risk sport despite the use of protective equipment and course adaptions. These injuries can have implications for nearby treating hospitals.
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Adra, Nabil, Kimberly Peihsi Ku, Maitri Kalra, Sandra Althouse, Nasser H. Hanna, Lawrence H. Einhorn e Costantine Albany. "Survival outcomes of patients with metastatic germ cell tumor (mGCT) treated from 1998 to 2012: The Indiana University (IU) experience." Journal of Clinical Oncology 34, n.º 2_suppl (10 de janeiro de 2016): 491. http://dx.doi.org/10.1200/jco.2016.34.2_suppl.491.
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491 Background: Patients with mGCT’s treated between 1975-1990 were classified by the International Germ Cell Cancer Collaborative Group (IGCCCG) into good, intermediate, and poor risk. This study attempts to identify prognostic factors in a contemporary cohort of patients with mGCT treated at IU. Methods: Retrospective analysis of all patients with GCT seen at IU from 1998-2012. 1,341 consecutive patients with mGCT were identified of whom 615 patients received initial chemotherapy at IU and were eligible for analysis. All patients in this cohort were treated with cisplatin-based combination chemotherapy. Kaplan-Meier methods were used for analysis of 5 year progression free survival (PFS) and overall survival (OS). Results: Median age was 29. Median follow up time 5 years. Good, intermediate, and poor risk disease had median AFP of 8, 1822, 291 and median hCG of 8, 5000, 12837 respectively. 89 (14%) patients had seminoma and 526 (86%) had non-seminomatous GCT (NSGCT). Primary site was testis/retroperitoneal in 565 (92%) and mediastinum in 48 (8%). The 5 year PFS and OS for patients with poor risk excluding primary mediastinal NSGCT (PMNSGCT) was 52% and 78% respectively. In contrast, 5 year PFS and OS for patients with PMNSGCT was 49% and 58% respectively. The results comparing outcomes of patients in IGCCCG versus patients at IU are depicted in the table below. Conclusions: In this contemporary retrospective dataset from Indiana University there was improvement in OS for men with poor risk mGCT, possibly due to improved salvage chemotherapy. Only patients with PMNSGCT continue to have poor outcomes and pose a therapeutic challenge due to lack of effective salvage therapy. [Table: see text]
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French, S. J., B. Murray, R. D. E. Rumsey, R. Fadzlin e N. W. Read. "Adaptation to high-fat diets: effects on eating behaviour and plasma cholecystokinin". British Journal of Nutrition 73, n.º 2 (fevereiro de 1995): 179–89. http://dx.doi.org/10.1079/bjn19950022.
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Twelve male subjects took part in a study to investigate the effects of overfeeding a high-fat diet (19·17 MJ/d; 58% energy from fat) for 2 weeks on plasma cholecystokinin (CCK) levels, food intake, and subjective feelings of hunger and fullness. Before and after the diet, subjects completed a 2-week weighed dietary inventory, formal measurements of food intake from a pre-selected appetizing evening meal were carried out, and blood samples were taken after a standard breakfast for measurement of CCK. Hunger and fullness were rated on visual analogue scales before and after each of these meals and at evening meals during the diet period. Following the high-fat diet there was a small non-significant increase in food intake from the pre-selected meal (6919 (SE 615) kJ ν 6405 (SE 540) kJ; P = 0·1) and a significant increase in the average daily food consumption measured from the diaries (10·25 (SE 0·49) MJ/d ν. 9·59 (SE 0·62) MJ/d; P = 0·05). Corresponding trends of increasing feelings of hunger and declining fullness also occurred over the study period. Plasma CCK responses to the standard breakfast were raised following the diet (1285 (SE 153) ν. 897 (SE 78) pM min; 3h integrated CCK production post ν. pre diet; P < ·01) with the major differences observed at 90 and 120 min following the meal. These results suggest that the increase in food intake may be related to a down-regulation in putative CCK receptors responsible for food intake. Elevated CCK levels might suggest a corresponding down-regulation in CCK receptors responsible for feedback inhibition of CCK release.
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Feng, G., L. Huang, J. Ji, C. Dong, Y. Xia, C. Cheng e Z. Gu. "POS0785 CHANGING EXPRESSION PROFILES OF LONG NONCODING RNAS, MIRNAS, MRNAS AND CIRCULAR RNAS IN LABIAL SALIVARY GLANDS OF PRIMARY SJÖGREN’S SYNDROME (PSS)". Annals of the Rheumatic Diseases 80, Suppl 1 (19 de maio de 2021): 645.3–646. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3784.
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Background:Primary Sjögren’s syndrome (pSS) is a relatively common autoimmune disease characterized by oral and ocular dryness. An increasing number of studies have revealed that long non-coding RNA (lncRNA), miRNA, mRNA and circular RNA (circRNA) contributes to the pathogenesis of autoimmune diseases.Objectives:To explore lncRNA, miRNA, mRNA and circRNA expression profiles in labial salivary glands (LSGs) in pSS patients and their biological functions in the regulation of pSS.Methods:The expression of 75,550 lncRNAs, 2,318 miRNA, 20,292 mRNAs and 6,877 circRNAs were determined in the LSG of six pSS patients and six healthy controls using microarray experiments. Validation was performed in pSS patients and controls using real-time PCR. LncRNA-mRNA co-expression and gene-pathway networks were constructed using bioinformatics software.Results:A total of 599 lncRNAs (upregulated: 279, downregulated: 320), 78 miRNAs (upregulated: 26, downregulated: 52), 615 mRNAs (upregulated: 590, downregulated: 25) and 160 mRNAs (upregulated: 110, downregulated: 50) were differentially expressed in the LSGs of pSS patients. Five of these lncRNAs were validated using real-time PCR. lncRNA HCP5, lncRNA SNHG5, lncRNA IFI44L, lncRNA CMPK2 were significantly upregulated and lncRNA TTYH1 were downregulated in pSS. GO and KEGG biological pathway analysis were performed to predict the functions of differentially expressed lncRNAs and co-expressed potential targeting genes. Subsequently, a ceRNA (lncRNA-miRNA-mRNA) network including 2320 ceRNA pairs was constructed based on predicted miRNAs shared by lncRNAs and mRNAs.Conclusion:The expression profile provided a systematic perspective on the potential functions of lncRNAs miRNAs, mRNAs and circRNAs in the pathogenesis of pSS. Therefore, this study will aid in the development of new diagnostic biomarkers and drug therapies.References:[1]Le Dantec C, Varin MM, Brooks WH, Pers JO, Youinou P, Renaudineau Y. Epigenetics and Sjogren’s syndrome.Curr Pharm Biotechnol. 2012 Aug;13(10):2046-53.Disclosure of Interests:None declared
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Ardizzoni, Andrea, Sergio Azevedo, Belen Rubio-Viqueira, Delvys Rodríguez-Abreu, Jorge Alatorre-Alexander, Hans J. M. Smit, Jinming Yu et al. "Primary results from TAIL: a global single-arm safety study of atezolizumab monotherapy in a diverse population of patients with previously treated advanced non-small cell lung cancer". Journal for ImmunoTherapy of Cancer 9, n.º 3 (março de 2021): e001865. http://dx.doi.org/10.1136/jitc-2020-001865.
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BackgroundAtezolizumab treatment improves survival, with manageable safety, in patients with previously treated advanced/metastatic non-small cell lung cancer. The global phase III/IV study TAIL (NCT03285763) was conducted to evaluate the safety and efficacy of atezolizumab monotherapy in a clinically diverse population of patients with previously treated non-small cell lung cancer, including those not eligible for pivotal trials.MethodsPatients with stage IIIB/IV non-small cell lung cancer whose disease progressed after 1–2 lines of chemotherapy were eligible for this open-label, single-arm, multicenter study, including those with severe renal impairment, an Eastern Cooperative Oncology Group performance status of 2, prior anti-programmed death 1 (PD-1) therapy, and autoimmune disease. Atezolizumab was administered intravenously (1200 mg every 3 weeks). Coprimary endpoints were treatment-related serious adverse events and immune-related adverse events.Results619 patients enrolled and 615 received atezolizumab. At data cutoff, the median follow-up was 12.6 months (95% CI 11.9 to 13.1). Treatment-related serious adverse events occurred in 7.8% and immune-related adverse events in 8.3% of all patients and as follows, respectively, in these subgroups: renal impairment (n=78), 11.5% and 12.8%; Eastern Cooperative Oncology Group performance status of 2 (n=61), 14.8% and 8.2%; prior anti–PD-1 therapy (n=39), 5.1% and 7.7%; and autoimmune disease (n=30), 6.7% and 10.0%. No new safety signals were reported. In the overall population, the median overall survival was 11.1 months (95% CI 8.9 to 12.9), the median progression-free survival was 2.7 months (95% CI 2.1 to 2.8) and the objective response rate was 11%.ConclusionsThis study confirmed the benefit–risk profile of atezolizumab monotherapy in a clinically diverse population of patients with previously treated non-small cell lung cancer. These safety and efficacy outcomes may inform treatment decisions for patients generally excluded from checkpoint inhibitor trials.
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Badiyepeymaiejahromi, Zohreh, Sara Shahsavari Isfahani, Nehleh Parandavar e Afifeh Rahmanian. "Nursing students perspectives regarding challenges of patient education in clinical settings". Bangladesh Journal of Medical Science 15, n.º 4 (18 de dezembro de 2016): 615–20. http://dx.doi.org/10.3329/bjms.v15i4.30719.
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Background: Patient education is an important component of patient care. It includes all educational activities to help patients and their families in order to make informed decisions about the disease and learn self-care skills. This study was conducted to investigate nursing students perspectives regarding the challenges of patient education in clinical settings.Material and Methods: This descriptive cross-sectional study was conducted on 78 third and fourth year nursing students of Jahrom University of Medical Sciences who were selected by census method. Data were collected through a valid and reliable questionnaire consisted of four parts. The first part was about demographic data, the second included 16 questions about importance of patient education, the third and fourth part contained 20 questions about challenges of patient education, 10 questions assessed barriers and 10 questions were about facilitators of patient education in clinical settings.Results: From the nursing students perspective, the average importance of patient education was 4.36±0.05 out of 5. The most important challenges regarding barriers of patient education were; lack of resources and educational tools, lack of enough time, inadequate knowledge and skills of the nurse, and lack of patient readiness both physically and psychologically. Also, the most important facilitators were; high skill and knowledge, having interest to education and phased implementation of patients education with respect to the patients condition. There was no relationship between academic year, sex and average grade with importance of patient education total score (p=0>05).Conclusion: Nursing managers and educational supervisors of hospitals need to pursue patients education programs with rely on the standards developed at national and international accreditation programs as a major strategy and provide necessary resources and educational tools.Bangladesh Journal of Medical Science Vol.15(4) 2016 p.615-620
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McVige, Jennifer, Said Shukri, Vincent Bargnes e Michael Lillis. "Neuroimaging of concussion patients in an outpatient clinic". Neurology 91, n.º 23 Supplement 1 (4 de dezembro de 2018): S14.1—S14. http://dx.doi.org/10.1212/01.wnl.0000550676.70350.2f.
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ObjectiveTo evaluate the use of neuroimaging safety, diagnoses, and potential treatment of patients with concussion.MethodsThis retrospective study took advantage of a concussion database to analyze neuroimaging in concussion patients of all ages. Details of neuroimaging orders were tracked and categorized as hospital emergency rooms, primary care physicians, neurologists at DENT, or by other specialists. Neuroimaging consisted of MRI and/or CT scans, which were classified as normal or abnormal. Abnormal MRI scans consisted of white matter changes, brain hemorrhage, chiari malformation, cyst arachnoid, hydrocephalus, incidental unrelated finding, or a developmental venous anomaly. Abnormal was further defined as abnormal due to head injury, unrelated to the concussion but unlikely to prolong recovery time, or unrelated to the concussion but may prolong recovery time.ResultsAmong the 835 diagnosed with concussion, 715 (86%) patients ages 1–78 had neuroimaging completed (615 MRI and 422 CT). Among these patients 401 (95%) had a CT order prior to coming to Dent, 319 (80%) from emergency rooms, 64 (16%) from primary care physicians, and 18 (4%) from other physician specialists. The rate of ordering an MRI was 46% greater than the rate of ordering a CT scans, while the rate of discovering an abnormality within MRI scans was 3 times greater than CTs (24.3% vs 7.8%).ConclusionsThere exists a remarkable discrepancy between the rate of ordering neuroimaging in concussion patients (46% more MRI vs CT orders) and the rate at which neuroimaging in these patients discovered brain abnormalities (×2.11 more in MRI vs CT reads). We acknowledge that improvement is required in the length of time in the MRI scanner and cost of MRI technology. However, additional consideration is required in abnormality detection effectiveness, cost efficiency, and radiation safety in balancing the use of MRI and CT technology.
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Matsuoka, Satoshi, Hidehiro Kaneko, Akira Okada, Akira Fukui, Yuichiro Yano, Hidetaka Itoh, Kojiro Morita et al. "Association between proteinuria and incident colorectal cancer: analysis of a nationwide population-based database". BMJ Open 12, n.º 4 (abril de 2022): e056250. http://dx.doi.org/10.1136/bmjopen-2021-056250.
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ObjectivesThis study aimed to assess whether adults with proteinuria were at a higher risk of incident colorectal cancer (CRC) than those without proteinuria using a large-scale population-based database.DesignA retrospective observational study.SettingThe JMDC Claims Database, an administrative health claims database, was used. Data were collected between 2005 and 2020.ParticipantsWe selected records of participants (n=3 543 705) who underwent health check-ups, including physical examinations, blood tests and urine dipstick tests. We excluded participants who were aged <20 years (n=25 577), had a history of CRC, colorectal disease, renal disease and renal replacement therapy (n=114 888), or had missing data on medications (n=170 145), cigarette smoking (n=14 835), alcohol consumption (n=366 414) or physical activity (n=106 550). Finally, we analysed 2 745 296 participants.Main outcome measuresThe primary outcome was CRC at any stage.ResultsParticipants were categorised as having no proteinuria (n=2 435 872), trace proteinuria (n=231 153) or positive proteinuria (n=78 271). Over a mean follow-up period of 1189±914 days, 10 615 CRC diagnoses were recorded. The incidence of CRC (95% CI) was lowest in participants without proteinuria (11.7; 95% CI, 11.5 to 11.9 per 10 000 person-years), followed by trace proteinuria (12.5; 95% CI, 11.7 to 13.3 per 10 000 person-years) and positive proteinuria (16.1; 95% CI, 14.6 to 17.7 per 10 000 person-years). After multivariable adjustment, compared with no proteinuria, HRs for incident CRC were 1.20 (95% CI, 1.12 to 1.29) and 1.23 (95% CI, 1.11 to 1.36) for trace and positive proteinuria, respectively. The association between proteinuria and incident CRC existed in participants after multiple imputations for missing data, with a follow-up period of ≥365 days, regardless of age, sex, obesity, hypertension, diabetes mellitus and estimated glomerular filtration rate.ConclusionsTrace and positive proteinuria were associated with a greater risk of incident CRC. Assessment of proteinuria could help identify individuals at an increased risk of CRC.
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Brun, M. K., K. H. Bjørlykke, J. E. Gehin, D. J. Warren, R. A. Klaasen, J. Sexton, Ø. Sandanger et al. "OP0060 CLINICAL CONSEQUENCES OF INFLIXIMAB IMMUNOGENICITY AND THE IMPACT OF THERAPEUTIC DRUG MONITORING: SECONDARY ANALYSES OF A RANDOMISED CLINICAL TRIAL". Annals of the Rheumatic Diseases 82, Suppl 1 (30 de maio de 2023): 40.2–40. http://dx.doi.org/10.1136/annrheumdis-2023-eular.3054.
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BackgroundNeutralising anti-drug antibodies (ADAb) are a problem in treatment with TNF-inhibitors (TNFi). Prospective data are needed to better understand how ADAb formation impacts safety and treatment outcomes of TNFi. Proactive therapeutic drug monitoring (TDM) allows for timely detection of ADAb and this strategy may have a role in reducing the negative clinical consequences of ADAb.ObjectivesTo explore the temporal relation between anti-infliximab antibody formation and treatment outcomes and adverse events, and to assess the impact of TDM as a strategy to reduce these consequences.MethodsPatients with immune mediated inflammatory diseases on infliximab therapy (n=615; 181 spondyloarthritis, 120 rheumatoid arthritis, 72 psoriatic arthritis, 114 ulcerative colitis, 83 Crohns disease and 45 psoriasis) were included in the Norwegian Drug Monitoring (NOR-DRUM) trials (1, 2) and randomised to TDM or standard infliximab therapy. Patients were followed for 30 and 52 weeks in the NOR-DRUM A (induction therapy) and NOR-DRUM B (maintenance therapy) trials, respectively. Neutralising ADAb were assessed with a drug sensitive automated fluorescence assay at each infusion. In this sub-study, we assessed the risk of; failure to achieve remission (analysis A), disease worsening during maintenance therapy (analysis B), treatment discontinuation (analysis C) and adverse events (analysis D) in patients developing ADAb compared to patients without ADAb using logistic- or cox regression and Kaplan-Meier survival analyses, stratified by TDM or standard therapy. Regression analyses were adjusted for potential confounders (Table 1). Remission and disease worsening were defined by disease specific composite scores (1, 2).ResultsADAb were detected in 147/615 (24 %) patients. Patients with ADAb had higher risk of not achieving remission 30 weeks after initiating infliximab therapy (odds ratio (OR) 2.4, 95 % confidence interval (CI) 1.3-4.2, P<0.01) (Table 1, Figure 1A) and of having a disease worsening during 52 weeks of infliximab maintenance therapy (hazard ratio (HR) 2.1, CI 1.4-3.3, P<0.001) (Figure 1B). ADAb formation was not significantly associated with adverse events in general, but the risk of infusion reactions was highly increased in patients with ADAb (HR 29, CI 11-78, P<0.001). The risk of infliximab treatment discontinuation was increased in ADAb positive patients (HR 6.5, CI 4.7-8.9, P<0.001). Patients developing ADAb in the TDM group had lower risk of disease worsening or an infusion reaction than patients with ADAb in the standard infliximab therapy group (Table 1, Figure 1B and C). Patients with ADAb discontinued infliximab treatment more often in the TDM group than in the control group (Table 1, Figure 1D).ConclusionFormation of ADAb led to poorer clinical outcomes both during induction and maintenance therapy with infliximab and increased the risk of infusion reactions. Early detection of ADAb by proactive TDM reduced the negative consequences of ADAb, both on infliximab effectiveness and safety, highlighting the role of proactive TDM in optimising TNFi therapy.References[1]Syversen SW et al. Jama. 2021;326(23)[2]Syversen SW et al. Jama. 2021;325(17)Table 1.Treatment and safety outcomes related to ADAb formation and TDMAnalysis A) Non-remissionOR (CI)PADAb2.4 (1.3-4.2)<0.01TDM1.0 (0.7-1.5)0.9Analysis B) Disease worseningHR (CI)PADAb2.1 (1.4,3.2)<0.01TDM0.4 (0.3-0.6)<0.001Analysis C) Infusion reactionHR (CI)PADAb29 (11-78)<0.001TDM0.3 (0.1-0.7)<0.01Analysis D) Treatment discontinuationHR (CI)PADAb6.5 (4.7-8.9)<0.001TDM1.4 (1.0-1.8)0.03Results from multivariable logistic (A)- or cox (B-D) regression models including the covariates: ADAb, TDM, age, sex, diagnosis, comedication. Results shown in table are risk of A) non-remission week 30, B) disease worsening during 52 weeks of maintenance therapy, C) infusion reactions and D) infliximab treatment discontinuation for patients developing ADAb and for patents in the TDM group.Figure 1.Acknowledgements:NIL.Disclosure of InterestsMarthe Kirkesæther Brun: None declared, Kristin Hammersbøen Bjørlykke Speakers bureau: Janssen, Grant/research support from: Olympus travel grant, Johanna Elin Gehin: None declared, David J Warren: None declared, Rolf A. Klaasen: None declared, Joseph Sexton: None declared, Øystein Sandanger: None declared, Tore K. Kvien Speakers bureau: Grünenthal, Sandoz, UCB, Consultant of: AbbVie, Amgen, Celltrion, Gilead, Novartis, Pfizer, Sandoz, UCB, Grant/research support from: AbbVie, Amgen, BMS, Galapagos, Novartis, Pfizer, UCB, Cato Mørk Speakers bureau: Novartis Norway, LEO Pharma, ACO Hud Norge, Cellgene, Abbvie, and Galderma Nordic AB, Jørgen Jahnsen Speakers bureau: AbbVie, Boerhinger Ingelheim, BMS, Celltrion, Giliad, Hikma, Janssen Cilag, Novartis, Orion Pharma, Pfizer, Roche, Takeda and Sandoz, Consultant of: AbbVie, Boerhinger Ingelheim, BMS, Celltrion, Giliad, Hikma, Janssen Cilag, Novartis, Orion Pharma, Pfizer, Roche, Takeda and Sandoz, Nils Bolstad: None declared, Kristin Kaasen Jørgensen Speakers bureau: Roche, BMS, Celltrion and Norgine, Espen A Haavardsholm Speakers bureau: Pfizer, UCB, Consultant of: AbbVie, Boehringer-Ingelheim, Eli Lilly, Gilead, Guro Løvik Goll Speakers bureau: AbbVie, Boehringer Ingelheim, Novartis, Pfizer, Orion Pharma, Eli Lilly, Roche, Sandoz, Silje Watterdal Syversen: None declared.
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Powell, BL, P. Olbrantz, D. Bicket e DA Bass. "Altered oxidative product formation in neutrophils of patients recovering from therapy for acute leukemia". Blood 67, n.º 6 (1 de junho de 1986): 1624–30. http://dx.doi.org/10.1182/blood.v67.6.1624.1624.
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Abstract During chemotherapy for acute leukemias, severe neutropenia allows acquisition of life-threatening infections that are difficult to clear with antibiotics alone. With return of myelopoiesis, even severe infections often improve dramatically. We have sequentially examined oxidative metabolic responses of polymorphonuclear leukocytes (PMNL) from 30 patients with acute leukemias before induction chemotherapy and after recovery of myelopoiesis (circulating PMNL greater than 500/microL). Maximal oxidative metabolic responses were quantitated by flow cytometric analysis of H2O2-dependent oxidation of intracellular 2′,7′-dichlorofluorescin (DCFH) in individual PMNL after stimulation with phorbol myristate acetate (PMA). Resting PMNL oxidized a mean of 6.8 attomoles (amol) DCFH/cell/15 min, with no difference between normal or patients' PMNL. PMA-stimulated normal PMNL oxidized 183 +/- 35 amol/cell (mean +/- SD, n = 120). In patients' PMNL obtained before chemotherapy, the mean DCFH oxidation was not significantly different from controls (216 +/- 78 amol/cell). However, 11 of 22 samples revealed populations of granulocytes with increased (primed) oxidative responses; seven of these 11 patients had proven or suspected infection at presentation. At recovery from chemotherapy-induced neutropenia, PMNL from 19 of 21 patients possessed one or more significant subpopulations with primed oxidation in response to PMA. In these 19 patients, 61% +/- 8% of PMNL comprised primed populations that oxidized 503 +/- 46 amol/cell. Oxidative activity was most pronounced in patients with proven or clinically suspected infections (with 41% +/- 9% of PMNL oxidizing 615 +/- 79 amol/cell). However, oxidative responses to PMA were also significantly increased in recovery PMNL from ten patients without clinical or laboratory evidence of active infection (79% +/- 11% of PMNL primed to oxidize 402 +/- 29 amol/cell). The peak responses of the primed subpopulations were short-lived and generally lasted three days or less, although oxidative responses remained elevated above normal for a week or more. All of the patients with increased PMNL responsiveness survived their hospitalization. In contrast, PMNL from four patients had a significant population (18% to 82% of cells) with reduced responsiveness. Two of these four patients (with 71% and 75% subnormal cells) died during this induction attempt; the third died during a second induction attempt; only one survived to discharge. The clinical significance of these phenomena is yet to be determined.(ABSTRACT TRUNCATED AT 400 WORDS)
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Powell, BL, P. Olbrantz, D. Bicket e DA Bass. "Altered oxidative product formation in neutrophils of patients recovering from therapy for acute leukemia". Blood 67, n.º 6 (1 de junho de 1986): 1624–30. http://dx.doi.org/10.1182/blood.v67.6.1624.bloodjournal6761624.
Texto completo da fonteResumo:
During chemotherapy for acute leukemias, severe neutropenia allows acquisition of life-threatening infections that are difficult to clear with antibiotics alone. With return of myelopoiesis, even severe infections often improve dramatically. We have sequentially examined oxidative metabolic responses of polymorphonuclear leukocytes (PMNL) from 30 patients with acute leukemias before induction chemotherapy and after recovery of myelopoiesis (circulating PMNL greater than 500/microL). Maximal oxidative metabolic responses were quantitated by flow cytometric analysis of H2O2-dependent oxidation of intracellular 2′,7′-dichlorofluorescin (DCFH) in individual PMNL after stimulation with phorbol myristate acetate (PMA). Resting PMNL oxidized a mean of 6.8 attomoles (amol) DCFH/cell/15 min, with no difference between normal or patients' PMNL. PMA-stimulated normal PMNL oxidized 183 +/- 35 amol/cell (mean +/- SD, n = 120). In patients' PMNL obtained before chemotherapy, the mean DCFH oxidation was not significantly different from controls (216 +/- 78 amol/cell). However, 11 of 22 samples revealed populations of granulocytes with increased (primed) oxidative responses; seven of these 11 patients had proven or suspected infection at presentation. At recovery from chemotherapy-induced neutropenia, PMNL from 19 of 21 patients possessed one or more significant subpopulations with primed oxidation in response to PMA. In these 19 patients, 61% +/- 8% of PMNL comprised primed populations that oxidized 503 +/- 46 amol/cell. Oxidative activity was most pronounced in patients with proven or clinically suspected infections (with 41% +/- 9% of PMNL oxidizing 615 +/- 79 amol/cell). However, oxidative responses to PMA were also significantly increased in recovery PMNL from ten patients without clinical or laboratory evidence of active infection (79% +/- 11% of PMNL primed to oxidize 402 +/- 29 amol/cell). The peak responses of the primed subpopulations were short-lived and generally lasted three days or less, although oxidative responses remained elevated above normal for a week or more. All of the patients with increased PMNL responsiveness survived their hospitalization. In contrast, PMNL from four patients had a significant population (18% to 82% of cells) with reduced responsiveness. Two of these four patients (with 71% and 75% subnormal cells) died during this induction attempt; the third died during a second induction attempt; only one survived to discharge. The clinical significance of these phenomena is yet to be determined.(ABSTRACT TRUNCATED AT 400 WORDS)
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Rodrigues, C. A., A. A. Teixeira, R. M. Ferreira, H. Ayres, A. L. Ranieri, B. G. Freitas e P. S. Baruselli. "180 PREGNANCY LOSS (BETWEEN 30 AND 60 DAYS) IN HIGH-PRODUCING REPEAT-BREEDER HOLSTEIN COWS SUBMITTED TO EMBRYO TRANSFER". Reproduction, Fertility and Development 22, n.º 1 (2010): 248. http://dx.doi.org/10.1071/rdv22n1ab180.
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Reproductive efficiency has a major impact on profitability of dairy farms. Pregnancy loss in cattle is one of the major impediments for adequate reproductive performance. The aim of the present study was to evaluate factors associated with pregnancy loss between 30 and 60 days of gestation in high-producing repeat-breeder (>4 services) Holstein cows submitted to embryo transfer (ET). A retrospective analysis was performed using data from 1 commercial dairy farm, located in Descalvado, Brazil (22°01′27″S; 47°53′19″L). Overall, 2096 ET were analyzed from 2004 to 2008. High-producing Holstein cows from the same herd were used as embryo donors. Embryos were produced by superovulation using the same protocol (8 decreasing injection of FSH) and were transferred, either fresh or frozen-thawed, to repeat-breeder Holstein recipients 6, 7, or 8 days after estrus (synchrony of Day 1, Day 0, or Day 1 with the donor, respectively). Statistical analysis was performed using PROC GLIMMIX of SAS (SAS Institute Inc., Cary, NC, USA). Variables included in the model were synchrony between recipient and donor at ET day, fresh and frozen-thawed embryos, stage of embryo development, and embryo quality. All cows were examined for pregnancy by ultrasonography 23 and 53 days after ET (30 and 60 days of pregnancy). There was no effect of year. The pregnancy loss was greater (P = 0.005) for fresh (22.9%, 141/615) v. frozen-thawed embryos (19.4%, 288/1481). Also, pregnancy loss was influenced (P = 0.002) by the synchrony between recipient and donor at ET day [Day -1:18.3% (53/290); Day 0: 18.9% (233/1234); D1: 24.9% (144/578)]. However, there was no difference in pregnancy loss when the stages of embryo development [morula: 20.7% (295/1428); early blastocyst: 18.9% (67/355); blastocyst: 23.0% (59/256); expanded blastocyst: 14.0% (8/57; P = 0.31)] and embryo quality [grade 1: 17.6% (78/443); grade 2: 20.1% (216/1073); grade 3: 23.3% (135/580); P = 0.31] were compared. In conclusion, pregnancy loss was greater in high-producing repeat-breeder Holstein cows receiving fresh embryos compared to frozen-thawed embryos and when Day 1 recipients were used compared to Day -1 and Day 0. Agrindus S/A.
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Mao, Mao, Shiyong Li, Qingqi Ren, Yi Luan, Weijie Liang, Shuaipeng Geng, Guolin Zhong et al. "Integrating multi-omics features for blood-based multi-cancer early detection." JCO Global Oncology 9, Supplement_1 (agosto de 2023): 156. http://dx.doi.org/10.1200/go.2023.9.supplement_1.156.
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156 Background: The current standard-of-care cancer screening paradigm is constrained to just a few cancer types and has challenges in patient compliance due to the invasive procedures endured from the tests. Recently studies have demonstrated that blood-based multi-cancer detection (MCED) approaches may hold promise for identifying asymptomatic cancer patients from the general population. However, most studies only exploit a single aspect of cancer hallmarks which is challenging for the biological reasons since cancer is a heterogenous disease with a wide spectrum of pathological and clinical behaviors. Methods: Here we report SeekInCare, a CE-IVD Mark MCED test, based on a novel multi-dimensional cancer risk score (CRS) model incorporating copy number aberrations, fragment size, end motifs and oncogenic viruses via shallow whole genome sequencing (sWGS) from cell-free DNA (cfDNA), and seven common tumor markers in a single 8ml blood draw. Results: Our research cohort consisted of 898 healthy subjects and 615 stage I-IV cancer patients that covered eight common cancers and 19 uncommon cancer types. The CRS model identified 427 cancer patients with 69.4% sensitivity at 98.0% specificity, resulting in an AUC (area under the curve) of 0.926. The sensitivities were 50.3%, 64.0%, 73.8% and 86.2% in stage I, II, III and IV cancers respectively. The sensitivities of eight common cancer types, breast, stomach, lung, colorectum, lymphoma, liver, pancreas and leukemia, were 45.1%, 50.0%, 63.4%, 69.4%, 70.5%, 81.4%, 82.4% and 90.9% respectively. We also prospectively evaluated SeekInCare in a real-world cohort consisting of 1212 subjects who received the test as a LDT (laboratory developed test) (median follow-up time: 753 days, range: 78~1669 days). 13 out of 18 cancer cases were detected while 46 subjects tested positive but without cancer. Thus, SeekInCare achieved 72.2% sensitivity, 96.1% specificity, 22.0% PPV and 99.6% NPV in the real-world cohort. Conclusions: In this study, we provided a non-invasive MCED test (SeekInCare) based on the multi-omics and multi-dimensional features. The case-control study demonstrated that SeekInCare could detect >20 cancer types with 69.4% sensitivity at 98.0% specificity. The outstanding real-world performance of SeekInCare warrants future investigation of its clinical utility and health economics as a mass cancer screening test in average-risk populations.
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Lushchik, A. A. "ASSESSMENT OF THE NEED FOR VEGETABLES IN ACCORDANCE WITH RATIONAL NORMS OF CONSUMPTION". Vegetable crops of Russia, n.º 2 (22 de abril de 2019): 16–21. http://dx.doi.org/10.18619/2072-9146-2019-2-16-21.
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Problems of proper nutrition and health of citizens are becoming increasingly important every year. A significant number of chronic non-communicable diseases have been observed in Russia and its regions for several years. Thus, according to the Territorial body of the Federal state statistics service for the Irkutsk region in 2017, the mortality rate from diseases of the circulatory system was 615 people per 100 thousand people, 218 people per 100 thousand people died from neoplasms. The reason for the increase in the incidence of population researchers believe the change in socio-economic structure, lifestyle and diet. At the same time, the President of the Russian Federation defined the task of achieving the average life expectancy of Russians at the level of 78 years in the may Decree of 2018. Currently, for the Irkutsk region, this figure is at the level of only 69 years and at the current rate of growth by 2024 will reach only 75 years. In this regard, we need a set of measures aimed at improving the health, living and working conditions of citizens of the country, which can be implemented, including through ensuring a normal diet of life and consumption of basic products, including vegetables, at a level not lower than the rational norms of their consumption. The article presents an assessment of the capacity and potential of the market of vegetable products on the materials of the Irkutsk region, the main producers, exporters, importers of vegetables, the forecast of shortage of vegetables. Social efficiency in achieving the proposed performance indicators will be determined by increasing the life expectancy of the population, reducing morbidity, improving the quality of life of those suffering from diseases associated with malnutrition, and the ratio of the obtained favorable social results to the costs to achieve them. Economic efficiency will be expressed by assessing the impact of the results achieved in the framework of program activities on the formation of the gross product, ensuring the dynamics of economic growth and increasing productivity, as stated in the presidential decree and Federal national projects until 2024. The practical application of vegetable demand calculations in accordance with rational consumption norms can be used in the process of marketing research to identify the potential market entry of new players or increase the production of fresh vegetables by their existing producers.
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Nazarina, Nazarina, Sri Prihartini e Rika Rachmawati. "Batasan indeks massa tubuh dan lingkar perut diabetesi di Indonesia untuk prediksi abnormalitas kadar HDL-kolesterol dan tekanan darah". Jurnal Gizi Klinik Indonesia 11, n.º 2 (30 de outubro de 2014): 49. http://dx.doi.org/10.22146/ijcn.18993.
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Background: According to National Basic Health Survey (Riskesdas) 2007 and 2013 in Indonesia, diabetes prevalence had been increasing from 1,1% to 1,5%. Diabetic tends to have obesity related to abnormal blood lipid level and high blood pressure which lead to some complications such as cardiovascular diseases and hypertension. Therefore early prevention of complications is needed.Objective: This study was to identify body mass index (BMI) and waist circumference (WC) cut-off point in Indonesian diabetic as the predictor of lipid profile and high blood pressure abnormality.Method: The Crossectional study using secondary data, Riskesdas 2007. Subjects in this study were 615 diabetics who admitted been diagnosed as diabetes by physicians and/or had oral glucose test result ≥ 200 mg%. Data that had been analyzed were lipid profile (total cholesterol, LDL-chol, HDL-chol) and systolic-diastolic blood pressure, BMI (kg/cm2), WC (cm), lifestyle, and subject’s characteristic. Receiver Operating Characteristic (ROC) is used to identify BMI and WC cut-off point for predicting lipid profile and blood pressure abnormality.Results: On the average, subjects have high blood pressure and dyslipidemia. Both IMT and LP are able to predict high blood pressure and low HDL-chol significantly (AUC ≥ 59; all p>0,05). BMI=23 kg/cm2 can predict low HDl-chol (Se=63,3%; Sp=54,0%; p=0,04), high systolic (Se=68,3%; Sp=60,6%; p=0,000) and diastolic (Se=68,3%; Sp=60,6%; p=0,000) blood pressure in men, whereas in women can predict only low HDL-chol (Se=72,3%; Sp=47,8%; p=0,000). LP=80 cm can screen high systolic (Se=73,8%; Sp=63,6%; p=0,000) and diastolic (Se=72,4%; Sp=55,3%; p=0,000) blood pressure in men and high systolic blood pressure in women (Se=71,5%; Sp=52,6%; p=0,000). However, to predict low HDL-chol in women, cut-off point of LP is 78 cm (Se=74,2%; Sp=41,5%; p=0,003).Conclusion: Although BMI and LP can be used to predict high blood pressure and low HDL-chol, however, both measures have the different function when they are applied to both gender. To predict low HDL-chol in men and women, BMI=23 kg/cm2 can be used, and LP=80 cm can be applied to screen high systolic blood pressure in both genders. Nevertheless, more research is needed to show the consistency of these results, such as using better study design and considering for confounding variables (ethnic, diabetes duration, lifestyle, hypertension, and diabetes medicine).
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Pichardo, Rayli, Yazan Abu Omar e Ding Wang. "Inpatient complications of immunotherapy-associated colitis in solid malignancies: Real-world data analysis." Journal of Clinical Oncology 40, n.º 16_suppl (1 de junho de 2022): 2657. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.2657.
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2657 Background: Immune checkpoint inhibitors (ICPis) and their containing regimens have been proven beneficial for the treatment of multiple malignancies, while immune-related adverse events (IrAEs) have become constant safety challenges in their clinical management through all ICPi therapies. Diarrhea resulted from immune-mediated colitis has been one of the most common IrAEs. The Aim of this study is to evaluate the real-world incidence and factors that contributed to colitis among patients hospitalized for anti-neoplastic immunotherapy using a large nation-wide database. Methods: We performed a retrospective analysis with the National Inpatient Sample (NIS) using ICD10-CM and PCS codes to identify patients with solid tumors hospitalized for immunotherapy between October 2015 and 2018. A comparison analysis was made between patients who developed diarrhea (or colitis) or not during their hospitalizations. Patient characteristics included past medical history, location, charges, length of stay (LOS) and inpatient complications variables, data were compared between the two groups. Results: The data from 5,795 admissions for immunotherapy were included, of which 615 (10.61%) inpatient events were complicated by diarrhea (colitis). Patients with diarrhea tended to be males (60%), slightly older at age 57 years, higher percentage of white patients (78%) though not statistically significant from those who did not have colitis. On the other hand, the length of inpatient stay was statistically longer (7 vs 5 days, p < 0.05), and associated with higher expenses ($214,612 vs $ 134,195, p < 0.05). In addition, inpatient admissions with colitis were more towards larger academic hospitals (80% vs 67%, p = 0.01). ICPi-treated patients with genitourinary (GU) cancers were observed more with colitis among these admissions (27% vs 15%, p < 0.05). Though no difference from mortalities observed, serious complications, such as acute kidney injury (AKI) (44% vs 20%, p < 0.05) and non-septic shock rates were higher (7% vs 2%, p = 0.01) among colitis admissions. Conclusions: This real-world data analysis of inpatient admissions from ICPi-treated cancer patients demonstrated colitis with diarrhea as a common safety concern over ICPi-therapies, a higher risk among patients of GU primaries, higher risk with serious medical complications: acute renal dysfunction and non-septic shock, led to increased length of stays (LOS) and financial burden. Special attention and further study may be placed among ICPi-treated GU cancer patients. [Table: see text]
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Midgley, Claire, Brian Rha, Joana Y. Lively, Angela P. Campbell, Julie A. Boom, Parvin H. Azimi, Geoffrey A. Weinberg et al. "2639. Respiratory Virus Detections in Asthma-Related Pediatric Hospitalizations: New Vaccine Surveillance Network, United States". Open Forum Infectious Diseases 6, Supplement_2 (outubro de 2019): S922—S923. http://dx.doi.org/10.1093/ofid/ofz360.2317.
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Abstract Background Respiratory viruses are associated with most asthma exacerbations (AEx) in children; however, the role of different viruses in AEx is unclear. We describe respiratory virus detections among pediatric inpatients with AEx (AEx-inpatients). Methods Through active, prospective surveillance at 7 US medical centers, we enrolled inpatients (<18 years) with acute respiratory illness (ARI) during November 1, 2015–June 30, 2016. We defined an AEx-inpatient as an inpatient with a principal admission or discharge diagnosis of asthma (ICD-10-CM, J45.xx). Mid-turbinate nasal and/or throat swabs were tested by molecular assays for influenza A or B, respiratory syncytial virus (RSV), parainfluenza virus 1–3, rhinovirus or enterovirus (RV/EV), human metapneumovirus and adenovirus. We assessed virus detections among AEx-inpatients throughout the surveillance period or by season (winter: December–February; spring: March–May), and by patient age and history of asthma/reactive airway disease (asthma/RAD). Results We tested 3,897 inpatients with ARI; of whom, 954 were AEx-inpatients. Most AEx-inpatients (741/954 [78%]) reported an asthma/RAD history. Viruses were more frequently detected among AEx-inpatients <5 years (350/458 [76%]) than 5–17 years (305/496 [61%], P < 0.001). Most (615/655 [94%]) detections were of single viruses. The most frequent single virus detections were RV/EV (474/954 [50%]) and RSV (76/954 [8%]) but the frequency of each virus varied by season and age group (figure). Single RV/EVs were the most common virus detections in both seasons and all groups. Single RSV detections were prominent among <5 year olds in winter (40/185 [22%]). Among those with single RV/EV or RSV detections, 285/474 (60%) and 49/76 (64%) required supplemental oxygen, respectively (P = 0.676); median length of stay was 1 day (range: 0–45; IQR: 1–2) and 2 days (range: 0–6; IQR: 1–2.5), respectively (P < 0.001). Conclusion AEx-inpatients <5 years were more likely to have respiratory virus detections than those 5–17 years. Single RV/EVs formed the majority of virus detections throughout the surveillance period, regardless of age. RSV played a notable role in winter among patients <5 years. These findings could inform prevention or treatment strategies for virus-associated AEx. Disclosures All authors: No reported disclosures.
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Dada, Sara, Kim Robin van Daalen, Alanna Barrios-Ruiz, Kai-Ti Wu, Aidan Desjardins, Mayte Bryce-Alberti, Alejandra Castro-Varela et al. "Challenging the “old boys club” in academia: Gender and geographic representation in editorial boards of journals publishing in environmental sciences and public health". PLOS Global Public Health 2, n.º 6 (21 de junho de 2022): e0000541. http://dx.doi.org/10.1371/journal.pgph.0000541.
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In light of global environmental crises and the need for sustainable development, the fields of public health and environmental sciences have become increasingly interrelated. Both fields require interdisciplinary thinking and global solutions, which is largely directed by scientific progress documented in peer-reviewed journals. Journal editors play a critical role in coordinating and shaping what is accepted as scientific knowledge. Previous research has demonstrated a lack of diversity in the gender and geographic representation of editors across scientific disciplines. This study aimed to explore the diversity of journal editorial boards publishing in environmental science and public health. The Clarivate Journal Citation Reports database was used to identify journals classified as Public, Environmental, and Occupational (PEO) Health, Environmental Studies, or Environmental Sciences. Current EB members were identified from each journal’s publicly available website between 1 March and 31 May 2021. Individuals’ names, editorial board roles, institutional affiliations, geographic locations (city, country), and inferred gender were collected. Binomial 95% confidence intervals were calculated for the proportions of interest. Pearson correlations with false discovery rate adjustment were used to assess the correlation between journal-based indicators and editorial board characteristics. Linear regression and logistic regression models were fitted to further assess the relationship between gender presence, low- and middle-income country (LMIC) presence and several journal and editor-based indicators. After identifying 628 unique journals and excluding discontinued or unavailable journals, 615 journal editorial boards were included. In-depth analysis was conducted on 591 journals with complete gender and geographic data for their 27,772 editors. Overall, the majority of editors were men (65.9%), followed by women (32.9%) and non-binary/other gender minorities (0.05%). 75.5% journal editorial boards (n = 446) were composed of a majority of men (>55% men), whilst only 13.2% (n = 78) demonstrated gender parity (between 45–55% women/gender minorities). Journals categorized as PEO Health had the most gender diversity. Furthermore, 84% of editors (n = 23,280) were based in high-income countries and only 2.5% of journals (n = 15) demonstrated economic parity in their editorial boards (between 45–55% editors from LMICs). Geographically, the majority of editors’ institutions were based in the United Nations (UN) Western Europe and Other region (76.9%), with 35.2% of editors (n = 9,761) coming solely from the United States and 8.6% (n = 2,373) solely from the United Kingdom. None of the editors-in-chief and only 27 editors in total were women based in low-income countries. Through the examination of journal editorial boards, this study exposes the glaring lack of diversity in editorial boards in environmental science and public health, explores the power dynamics affecting the creation and dissemination of knowledge, and proposes concrete actions to remedy these structural inequities in order to inform more equitable, just and impactful knowledge creation.
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Barnato, Sara E., Charles L. Bennett, Kathleen Elverman, Dennis P. West e Mark Courtney. "Evaluating Mortality with Erythropoietic Stimulating Agents (ESAs) in the Nephrology Setting: The Distinction between Evaluating Trials That Measure Survival as a Primary or Secondary Efficacy Endpoint Versus a Safety Endpoint." Blood 110, n.º 11 (16 de novembro de 2007): 962. http://dx.doi.org/10.1182/blood.v110.11.962.962.
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Abstract Background: At ASCO 2007, we reported increased mortality risks when ESAs are administered to anemic cancer patients who are receiving chemotherapy when target hemoglobin levels are beyond the correction of anemia. In February 2007, a meta-analysis of nine randomized clinical trials with 5,143 patients published in the Lancet [vol 369; 381–88] identified a statistically significant risk of all cause mortality (relative risk (RR) of 1.17, 95% confidence interval (CI) 1.01, 1.35) when anemic patients with chronic kidney disease received ESAs targeted to higher hemoglobin concentrations (120–150 g/L). A recent report from the RADAR (Research against Adverse Drug Reactions) group raises concern that survival analyses might differ depending on whether survival was evaluated as a measure of efficacy versus a measure of safety. Herein, we re-analyze the data by evaluating randomized clinical trials according to whether or not survival was prospectively included as a primary or secondary efficacy outcome. Methods: Risks of death in randomized controlled clinical trials included in the Lancet meta-analysis were evaluated. We classified those studies based on their mortality outcomes, either as an efficacy outcome or as a safety outcome. Effect estimates for RR and 95% CI were derived from Stata (version 9.1, College Station, TX), calculated with random-effects models and pooled by use of the Dersimonian and Laird method. Results: In studies where survival was measured as an efficacy endpoint, the relative risk of mortality with ESAs targeted to higher hemoglobin levels was 1.27 (1.08, 1.49), a number greater than the relative risk reported in the Lancet meta-analysis. Conclusions: Randomized controlled trials should be included in meta-analyses that evaluate harms only if the relevant safety measure is prospectively included as a primary or secondary efficacy outcome measure in the study protocol. When survival was included as part of the efficacy analysis, a statistically significant safety signal was present. Randomized trials that included harms as a measure of safety did not present a statistically significant safety signal. Including randomized trials that include harms as a safety measure introduce noise and can mask safety signals. Studies: Events: RR (95% CI) Survival included as a primary or secondary efficacy outcome measure: High vs Low Hb Target: Besarab 1998 (n=1233) 183/618 vs 150/615 1.21 (1.01, 1.46) Gouva 2004 (n=88) 4/43 vs 3/45 1.40 (0.33, 5.87) Drueke 2006 (n=602) 31/300 vs 21/302 1.49 (0.87, 2.53) Singh 2006 (n=1432) 52/715 vs 36/717 1.45 (0.96, 2.19) Subtotal (n=3355) 270/1676 vs 210/1679 1.27 (1.08, 1.49) Survival included only as a safety measure: High vs Low Hb Target: Foley 2000 (n=146) 4/73 vs 3/73 1.33 (0.31, 5.75) Furuland 2003 (n=416) 29/216 vs 27/200 0.99 (0.61, 1.62) Roger 2005 (n=154) 0/75 vs 0/79 not estimable Levin 2005 (n=152) 1/74 vs 3/78 0.35 (0.04, 3.30) Parfrey 2005 (n=696) 12/396 vs 20/300 0.45 (0.23, 0.92) Rossert 2006 (n=390) 1/195 vs 6/195 0.17 (0.02, 1.37) Subtotal (n=1954) 47/1029 vs 59/925 0.67 (0.37, 1.19)
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Silva, Maria Gomes, Susana Esteves, Inês Barbosa e José Cabeçadas. "Hodgkin's Lymphoma in the Portuguese Population – Epidemiological and Pathological Characterization." Blood 114, n.º 22 (20 de novembro de 2009): 4634. http://dx.doi.org/10.1182/blood.v114.22.4634.4634.
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Abstract Abstract 4634 Classical Hodgkin's lymphoma (cHL) has a bi-modal age distribution in the Western World, with a peak in young adults and another over 50 yo. The nodular sclerosis subtype predominates, mainly in the first group. In contrast, in developing countries, higher incidences in childhood and elderly populations and a predominance of the mixed cellularity subtype is observed. The epidemiological characteristics of the disease in Portugal, an European country with an elevated number of immigrants from West Africa, have not been reported. We aimed to determine the histological distribution and sex and age-specific incidence of Hodgkin's lymphoma in the Portuguese population and compare it to the Western pattern. For that, we performed a retrospective analysis of all cases registered at the Portuguese Cancer Registry-South Region (a network comprising 29 hospitals representative of the country's epidemiology) between 1999 and 2003 and determined the sex and age-specific incidence (cases/100 000 inhabitants) and exact 95% confidence intervals. Population data was obtained from the National Institute of Statistics. To investigate a possible recent trend for higher incidences in older ages, as has been described in other western countries, we used the Standardized Incidence Ratio (SIR) for comparison between 2006-2007 and 1999-2000. A total of 615 cases were diagnosed in the south of Portugal between 1999 and 2003, with a male/female ratio of 1.24:1. The age specific incidence revealed a bi-modal distribution with a peak at 15-24 yo (4.41/100 000 inhabitants) and another at 65-74 yo (2.94/100 000/inhabitants). The incidence of the disease in individuals older than 55 in 1999-2000 and 2006-2007 (3.56 and 3.81 in men, respectively, and 1.89 and 2.87 in women, respectively) increased by 25% (SIR:1.25, 95% CI:1.02-1.52, p=0.03 two-sided Mid-P exact test). This was mainly attributable to an increased incidence in women older than 55 (SIR:1.50; 95% CI:1.12-1.99, p=0.007), whereas in men the incidence remained stable (SIR:1.07, 95% CI:0.80-1.41, p=0.60). Since the registry data did not include histology in 27% cases, we systematically reviewed the pathological specimens of 229 consecutive patients diagnosed in our tertiary cancer care center during the same period (1999-2003). These patients were younger than the ones diagnosed in the other network hospitals (median age 29 and 40.5 yo, respectively, p<0,001 Mann-Whitney test), with a similar male to female ratio. 92% were subclassifiable. From these, 5% had nodular lymphocyte predominance HL and 95% (199 cases) cHL. Nodular sclerosis accounted for 89% of cHD and mixed cellularity for 6.5% of cases. From the other 233 registry cases classified as cHD, 78% were also nodular sclerosis. In Portugal, where immigration from African countries could have lead to different disease characteristics, epidemiological patterns of HL are similar to the Western ones. Similarly to reports from other western countries, we observed a trend for an increased incidence in the elderly. A higher than expected proportion of nodular sclerosis subtype was found in a subgroup analysis, which may be related to the younger age reported in this subgroup. Disclosures: No relevant conflicts of interest to declare.
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Pollyea, Daniel A., Amanda Winters, Craig T. Jordan, Clayton Smith e Jonathan A. Gutman. "Allogeneic Transplant Improves AML Outcomes Compared to Maintenance Venetoclax and Azacitidine Following Response to Initial Venetoclax and Azacitidine Therapy". Blood 136, Supplement 1 (5 de novembro de 2020): 24. http://dx.doi.org/10.1182/blood-2020-138821.
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Venetoclax and azacitidine (ven/aza) is our institutional preference for initial treatment of non-core binding factor AML patients age ≥60. Given potential durability of response in these patients, the role of transplant (SCT) in patients who achieve response to ven/aza is uncertain. To examine the potential contribution of SCT, we identified 119 patients age ≥60 who received ven/aza as initial AML therapy at our center between 1/2015 and 1/2020. We then compared outcomes for these patients based on whether they were deemed eligible or ineligible for SCT; for those deemed eligible, we compared outcomes between patients who received SCT and those who did not due to personal preference. SCT consults were generally conducted within 2 cycles of initiation of ven/aza but were delayed in some patients achieving CR until evidence of persistent or recurrent measurable residual disease (MRD). Among the 119 patients, 61 (median age 76 (61-90)) were not SCT candidates due to age or comorbidities (n=44) or early death due to primary refractory disease/acute toxicity (n=17). 60 patients were potential SCT candidates. 21 patients median age 65 (60-73) underwent SCT. 2 of these patients had MDS prior to developing AML and underwent SCT consult before developing AML and initiating ven/aza. For the remaining 19 patients, consult occurred median of 50 days (20-287) from diagnosis. 2 patients relapsed after initiating ven/aza prior to transplant, underwent induction, and then went on to SCT. SCT occurred median 176 (69-643) days from diagnosis and median 133 (49-615) days from SCT consult. 37 patients median age 72 (64-78) had SCT consults but did not undergo SCT. 5 of these patients had refractory disease and never achieved SCT eligibility, one patient was deemed not an SCT candidate after consult due to social issues, and one patient was lost to follow up. The remaining 30 patients median age 72 (64-78) achieved adequate response for SCT but elected to defer. 2 of these 30 patients had MDS prior to developing AML and underwent SCT consult before developing AML and initiating ven/aza. Among the 28 patients who had SCT consults after initiating ven/aza and deferred SCT, SCT consult occurred median of 64 days (14-222) from diagnosis. Details of ELN risk status and disease status at time of SCT consult, time of SCT, and best disease response for non-SCT patients are provided in Table 1. MRD positivity included disease detected by cytogenetics, FISH, flow cytometry, or digital droplet PCR (ddPCR). Donor sources were cord (n=11), haplocord (n=3), and matched related donor (n=7). Conditioning regimens included 7 non-myeloablative, 12 reduced-intensity, and 2 myeloablative. Overall survival (OS) was significantly greater among SCT patients (median survival not reached) versus patients undergoing SCT consult and deferring SCT (median 588 days) (p=0.01) versus patients not considered SCT candidates due to age or comorbidities (median 291 days) (p=<0.001). OS was significantly greater for patients undergoing SCT consult and deferring SCT versus patients not considered SCT candidates due to age or comorbidities (p=0.01) (Figure 1). Among patients SCT eligible but deferring SCT, OS trended toward improved among patients with best disease response of CR or CRi without MRD (n=22 median 811 days) versus patients whose best disease response continued to include MRD (n= 8 median 443 days) (p=0.13). Favorable ELN status (n=10) was associated with improved OS compared to intermediate or unfavorable (n=20) (p=0.036, median survival 871 versus 443 days). Among SCT patients, OS was comparable whether patients went to SCT with (n=14) or without MRD (n=7) (p=0.49). ELN status did not impact OS; only 3 patients had favorable status. Median survival was not reached in any arm. For SCT eligible patients, SCT appears to improve outcomes among patients who respond to ven/aza compared to patients who defer SCT. Preliminary data suggests that outcomes may be improved for patients going to transplant with MRD following initial therapy with ven/aza as compared to traditional chemotherapy induction. Ongoing data to further refine the significance of MRD, molecular and cytogenetic prognostic factors, and optimal timing of SCT, as well as standardized tools to assess MRD, are necessary. Disclosures Pollyea: Syndax: Consultancy; Glycomimetics: Other; Syros: Consultancy; Abbvie: Consultancy, Research Funding; Karyopharm: Consultancy; Takeda: Consultancy; Daiichi Sankyo: Consultancy; Agios: Consultancy; Celgene/BMS: Consultancy; Pfizer: Consultancy; 47: Consultancy, Research Funding; Janssen: Consultancy; Amgen: Consultancy; Genentech: Consultancy; Novartis: Consultancy.
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Varon, David E., Kristo Nuutila, Laura E. Cooper, Javier Chapa, Franklin Valdera, Sean E. Christy, Robert J. Christy, Rodney K. Chan e Anders H. Carlsson. "615 Evaluation of Topical Off-The-Shelf Therapies to Improve Burn Wound Healing During Prolonged Field Care". Journal of Burn Care & Research 43, Supplement_1 (23 de março de 2022): S147—S148. http://dx.doi.org/10.1093/jbcr/irac012.243.
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Abstract Introduction Burns are common injuries in the battlefield. Given austere environments, prolonged field care (PFC) is often necessary. Delays in surgical debridement create a risk of infection and deranged healing for burn patients. As such, this study attempts to identify the best commercially available off-the-shelf (OTS) dressings with field-deployable potential. Methods Deep-partial thickness burns (1" diameter) were created on the dorsum of 3 anesthetized pigs utilizing a thermocoupled burn device at 100°C for 15s. Non-surgical debridement was done 1-h post-burn creation and either an OTS dressing or standard-of-care (SOC) treatment (Silver Sulfadiazine) was applied to the wound in order to simulate a PFC environment. OTS dressings were randomized and included irradiated sterile human skin allograft (ISHSA), alloplastic absorbable skin substitute (AASS), and synthetic polyurethane dermal matrix (SPDM). Wounds were serially assessed on post-burn days 3, 7, 14, 21, and 28. Assessments were conducted using a combination of photographs, histology, and quantitative bacteriology. Endpoints included burn wound progression, re-epithelialization, wound contraction, scar elevation index (SEI), and colony forming units (CFU). Results No statistically significant differences in burn wound progression were seen on days 3 and 7 for the ISHSA or SPDM and the SOC. The differences between the AASS and the SOC were statistically significant on both days (p≤0.05). Day 21 re-epithelialization results for the ISHSA, AASS, SPDM and SOC treated wounds were 30%, 85%, 95%, and 78% re-epithelialized, respectively. The difference between the AASS and the SOC was statistically significant (p≤0.05). Results showed that by day 28, wound contraction for the ISHSA, AASS, SPDM and SOC treated wounds were 65%, 80%, 82%, and 78%, respectively. No statistically significant differences in wound contraction were seen for any of the OTS dressings and the SOC. SEI showed no statistically significant difference in scar hypertrophy between the OTS dressings and the SOC on day 28. CFU results showed no statistically significant differences between the OTS dressings and the SOC on days 3 and 7. Conclusions Three OTS dressings were compared to the SOC for use in the PFC setting. Generally, all the dressings performed well when compared to the SOC in terms of burn wound progression, re-epithelialization, wound contraction, SEI, and CFU. Although significant differences in burn progression and re-epithelialization for burns treated with AASS were seen. In the future, we hope to continue to discover and test various OTS dressings to determine their appropriateness for use in the PFC setting.
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Musto, Pellegrino, Alberto Grossi, Ennio Sarli, Michele Cavo, Federica Leotta, Mario Boccadoro e Antonio Palumbo. "A Score Model for Predicting Unsuccessful or Sub-Optimal Peripheral Blood Stem Cell Collections in Multiple Myeloma Based on a Retrospective Analysis of 1,039 Patients Receiving Novel Agents As Induction Therapy and Cyclophosphamide Plus G-CSF As Mobilizing Regimen",. Blood 118, n.º 21 (18 de novembro de 2011): 4044. http://dx.doi.org/10.1182/blood.v118.21.4044.4044.
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Abstract Abstract 4044 Induction therapy with the so-called “novel agents” (bortezomib or IMIDs) followed by autologous stem cell transplantation (AuSCT) is considered the current standard therapeutic approach for younger patients with multiple myeloma (MM). However, a variable proportion of these patients still fails to mobilize and to collect a number of CD34+ peripheral blood stem cells (PBSC) sufficient for a safe transplant procedure or, as required in selected patients, for double or salvage AuSCTs. The aim of this study was to analyze, in a large number of MM initially treated with novel agents and homogeneously mobilized, the role of some potential risk factors on PBSC collection in patients eligible for AuSCT. To this purpose, the impact of age > 60 years, baseline cytopenia at diagnosis (Hb< 10 g/dl and/or neutrophil count < 1,000/μl and/or platelet count < 100,000/μl), initial use of lenalidomide and grade 3–4 hematological toxicity during induction therapy were retrospectively evaluated in 1,337 previously untreated MM patients enrolled in five consecutive clinical trials finalized to AuSCT and conducted by GIMEMA cooperative Group and MM Italian Network. In all cases, the mobilizing regimen was cyclophosphamide + G-CSF. In four of these studies, including 1,039 patients, induction regimens had comprised novel agents: thalidomide (TD, 296 patients), bortezomib (PAD, 121 patients), thalidomide plus bortezomib (VTD, 219 patients), lenalidomide (RD, 403 patients). 298 patients treated with a VAD-modified induction regimen (DAV) were also evaluated. Data were retrospectively extracted from two different databases of the coordinating Centers (Torino and Bologna) using a single, dedicated excel file. Total amounts of less than 2 and less than 5 × 10e6/kg CD34+ PBSC after a single mobilizing procedure were considered as “unsuccessful ” or “sub-optimal” results, respectively. Overall, 917 patients (68.6%) showed the presence of at least one risk factor: 615 patients (46%) had only 1 parameter, 302 a combination of 2 (n. 237, 17.7%), 3 (n. 56, 4.2%) or 4 (n. 9, 0.7%) parameters, respectively. After a single PBSC mobilization, 413 patients (30.9%) had a sub-optimal result, including 256 patients (19.1%) with unsuccessful collection. Any single parameter negatively influenced PBSC collection vs absence of parameters (p < 0.000). At multivariate analysis, however, grade 3–4 hematological toxicity (p < 0.000) and the use of lenalidomide (p < 0.013) during induction showed the most powerful negative effects on mobilization. The number of present risk factors (from 4 to 0) significantly paralleled the ineffective procedures, both in terms of absolute median amount of CD34+ PBSC collected (from 1.2 to 10.6 × 10e6/kg) or percentage of unsuccessful/sub-optimal collections (from 78% to 13% and from 89% to 24%, respectively) (p < 0.000). On these basis, we constructed a predictive score where the four parameters were pooled and weighted according to their relevance as single or combined variables, attributing the value of 3 for grade 3–4 hematological toxicity, 2 for the use of lenalidomide and 1 each for age > 60 and baseline cytopenia. Applying this model, we found that the risk of collecting less than 2 (27.5% vs 17.3%) and less than 5 (41% vs 28.6%) × 10e6/kg CD34+ PBSC, was significantly higher in patients with a total score equal or >3 than in patients scored <3 (p < 0.000 for both comparisons). These data did not differ significantly when the patients who had not received novel agents as induction therapy were excluded from the analysis. In conclusion, our score model provides a simple and effective method to predict unsatisfactory PBSC collections in MM patients eligible for AuSCT who have received novel agents as induction therapy and a combination of chemotherapy plus G-CSF as mobilizing treatment. Disclosures: Musto: Genzyme: Honoraria. Grossi:Genzyme: Consultancy. Sarli:Genzyme: Honoraria. Cavo:Genzyme: Honoraria. Boccadoro:Genzyme: Honoraria. Palumbo:Genzyme: Honoraria.
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Colace, Susan I., Meenakshi Devidas, Zhiguo (Bruce) Chen, Robert J. Hayashi, Brent L. Wood, Natia Esiashvili, Samir Patel et al. "Risk-Adjusted Therapies Yield Equivalent Outcomes for Adolescents and Young Adults (AYAs) Treated for Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia (T-ALL) on Children's Oncology Group (COG) Studies AALL0434 and AALL1231". Blood 142, Supplement 1 (28 de novembro de 2023): 517. http://dx.doi.org/10.1182/blood-2023-190141.
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Introduction Previous clinical trials have reported that adolescent and young adult (AYA) patients treated for T-cell acute lymphoblastic leukemia (T-ALL) have lower disease-free survival (DFS) and overall survival (OS) and increased toxicity as compared to younger patients. Results for the AYA cohort treated on two COG international phase 3 trials for T-ALL are reported here. Patients and Methods AALL0434 enrolled 1562 T-ALL patients (2007-2014) and AALL1231 enrolled 615 T-ALL patients (2014-2019) treated on augmented BFM (ABFM) regimens. AYA patients were defined as age ≥16 years of age (AALL0434: n=226; AALL1231: n = 107). Both studies allowed enrollment up to age 31 years. On AALL0434, participants were randomized to receive escalating dose methotrexate (CMTX) without leucovorin rescue + pegaspargase or high dose MTX (HDMTX) + leucovorin rescue. Intermediate and high-risk patients were randomized to receive or not receive six 5-day courses of nelarabine (Nel). Risk group assignments in AYA vs non-AYA patients can be found in Table 1. On AALL1231, participants were randomized to receive or not receive bortezomib in Induction and Delayed Intensification. Key differences between AALL0434 and AALL1231 ABFM backbones included the use of prednisone in induction in AALL0434 versus dexamethasone in AALL1231, and cranial radiation therapy in the majority of AALL0434 participants versus only in patients with central nervous system involvement in AALL1231. Results On AALL0434, the 4-year DFS for AYA was 81% compared to 84% for those <16 years old (P=0.5965), and OS was 88% and 90% respectively (P=0.3478). AYA patients randomized to CMTX (n=70) had a superior DFS compared to those randomized to HDMTX (n=72) with 4-year DFS 96% versus 78% respectively (P=0.0038). No disadvantage was seen among AYA subjects who received nelarabine versus those who did not, as shown by a 4-year DFS 85% versus 89%, respectively (N=54) (P=0.8116), albeit the sample size was small. On AALL1231, the 4-year EFS for AYA (n=107) was 82.7±3.9% compared to 82.2 ±1.7% for non-AYA (n=508) (P=0.727), and OS was 86.5 ±3.5% and 88.4 ±1.5% respectively (P=0.553). No difference in outcome was seen for AYA patients randomized to receive/not receive bortezomib. Combined outcome data for AALL0434 and AAL1231 demonstrates 4-year EFS for AYA (n=333) of 82.2+2.4% vs 83.9+0.9% for non-AYA (n=1844) (P=0.52) (Figure 1) and OS of 87.5+2.1% vs 90+0.8% respectively (P=0.19). Significant differences in patient characteristics in AALL0434 were higher initial white blood counts (P=0.0004) and higher risk group category (P=0.0002) for AYA patients. There were no significant differences in the AALL0434 AYA cohort compared to younger patients in CNS disease status, race, ethnicity, remission status at end of induction, or day 29 end of induction minimal residual disease (MRD). Toxicity rates were not significantly different in non-AYA vs AYA patients with the exception of upper respiratory infection (9.4% vs 1.8%; P=0.0001) and osteonecrosis (4.8% vs 17.7%; P<0.0001) in AALL0434. Rates of sepsis, catheter-related infection, and other infections were not significantly different between AYA and younger patients in AALL0434. Analysis of patient characteristics and toxicity rates in AALL1231, as well as analysis of the combined toxicity data for AALL0434 and AAL1231, are currently underway and will be presented at the meeting. Conclusion COG AALL0434 and AALL1231 show outstanding overall outcomes for AYA patients with no significant difference in survival between AYA and non-AYA patients on either study, despite differences in the ABFM backbones and the higher risk features seen among the AYA group in AALL0434. There were similar occurrences of therapy-related toxicities for AYA and non-AYA study participants on AALL0434. Despite small numbers, CMTX holds a survival advantage for AYA T-ALL patients, with no survival disadvantage seen among AYA T-ALL patients who received Nel. Bortezomib does not offer significant benefit for AYA T-ALL patients.
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Kazenas, E. K., N. A. Andreeva, G. K. Astakhova, V. A. Volchenkova, O. A. Ovchinnikova, T. N. Penkina e O. N. Fomina. "Composition of vapor and thermodynamic characteristics of gaseous molecules tungstates of alkali earth metals". Physics and Chemistry of Materials Treatment 5 (2023): 72–78. http://dx.doi.org/10.30791/0015-3214-2023-5-72-78.
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Calculated and experimental mass spectra (at temperatures region of 1600 – 2000 K) of gaseous alkaline earth metals tungstates: MgWO4(g), CaWO4(g), SrWO4(g), BaWO4(g) are given. The partial vapor pressures are determined and the equations for the temperature dependences of the partial pressures of gaseous molecules of alkaline earth metals tungstates were derived for liquid in the form (Р, atm): lgP(MgWO4(L)) = –28737/Т + 7,95 for the area 1600 – 1900 K; lgP(CaWO4(L)) = – 25265/Т + 6,913 for the area 1850 – 2000 K; lgP(SrWO4(L)) = – 25052/Т + 7,13 for the area 1800 – 1900 K; lgP(BaWO4(L)) = –20570/Т + 4,58 for the area 1770 – 1900 K. Based on experimental data on vapor pressure, the enthalpies of evaporation (DН0s,0), formation (–DН0f,0) and atomization (DН0at,0) of gaseous alkaline earth metals tungstates were calculated, which respectively amounted to (DН0, kJ/mol): MgWO4 — 652, 890, 2855; CaWO4 — 644, 974, 2968; SrWO4 — 615, 1045, 3056; BaWO4 — 548, 1045, 3095. The enthalpy of sublimation of alkaline earth metals tungstates decreases from magnesium to barium.
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Side, Jonathan, Charles Herd e Wells Grogan. "OIL SPILL POLLUTION: THE NORTH SEA EXPERIENCE OF COOPERATIVE MEASURES". International Oil Spill Conference Proceedings 1985, n.º 1 (1 de fevereiro de 1985): 615–20. http://dx.doi.org/10.7901/2169-3358-1985-1-615.
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ABSTRACT The North Sea is a relatively small yet intensely used area, rich in various resources. It is bounded by six highly industrialized states and contains the world's busiest shipping channel. It exemplifies the problems of control and management of marine resources, in particular in relation to oil pollution. This paper summarizes major sources of hydrocarbon pollution in the North Sea, discussing the levels and different types of oil pollution arising from different activities. The international and regional conventions bearing on hydrocarbon pollution in the North Sea are documented with reference to some recent comments on the adequacy of the existing legal regime. Initiatives to improve and develop scientific and technical knowledge and cooperation among North Sea states are examined. Specific measures to establish arrangements for monitoring and remedial action in the event of an oil spill are discussed. The paper also describes the implementation of MARPOL 73/78 for the North Sea, documents European Economic Community responses to oil pollution, and, finally, discusses the most recent initiative, the International North Sea Conference (November 1984) that will address the complex problem of oil pollution in the North Sea.
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Cieri, Nicoletta, Liang Li, Nidhi Hookeri, Kari Stromhaug, Julia Keating, Jonathan Stevens, Kameron Kooshesh et al. "An Analytic Framework for the Prediction of Gvl Minor Histocompatibility Antigens to Prevent or Treat Post-Transplant Relapse". Blood 142, Supplement 1 (28 de novembro de 2023): 361. http://dx.doi.org/10.1182/blood-2023-187705.
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The therapeutic effect of allo-HSCT relies on T cell alloreactivity driven by genetic nonidentity between donor and recipient (D-R) pairs. In the setting of HLA-matched transplants, endogenous proteins in recipient cells differing from those of the donor due to genetic polymorphisms, can provide distinct HLA-binding peptides, serving as minor histocompatibility antigens (mHAgs). Hematopoietically-restricted mHAgs represent ideal targets to separate graft-versus-leukemia (GvL) from graft-versus-host-disease (GvHD) effects. To date,however, the quest for optimal GvL mHAgs has resulted in the identification of only a handful of targets, raising concerns on the clinical feasibility of their targeting. We hypothesized that systematic mHAg prediction from whole-exome sequencing (WES) of D-R pairs could help identifying novel candidate mHAgs with an acceptable safety profile for therapeutical targeting. We focused on AML/MDS, the most common indications for allo-HSCT in adults. To capture the transcriptional heterogeneity of malignant myeloid cells, we applied a single-cell based classifier to define genes expressed by leukemic cells in the Beat AML cohort, and then removed those expressed in non-hemopoietic tissues, per the GTEx RNA and protein database. Similarly, a broader set of pan-hematopoietic genes was defined starting from the expression profiles of 18 mature hematopoietic lineages and hematopoietic stem and precursor cells. Through this process, we identified 259 genes with preferential expression in AML and 615 broadly expressed in the hematopoietic compartment. We applied this analytical pipeline to WES from 220 HLA-matched D-R pairs transplanted at DFCI. To discover mHAgs with optimal GvL potential, we focused on the subgroup of 45 patients with long-term survival in the absence of both relapse and GvHD requiring systemic treatment (i.e. GvHD-free/relapse-free survival [GRFS]). For these patients experiencing purely GvL, we analyzed the individual repertoire of predicted GvL mHAgs, and found 86 SNPs recurring in ≥5 GRFS patients. These GvL SNPs were enriched in the subgroup of GRFS patients versus those without GRFS, suggesting that their overrepresentation was not dictated by high allelic frequency in the overall cohort. Using the median number of recurring GvL mHAgs in the GRFS subgroup (‘GRFS mHAgs‘) as a cutoff to stratify the entire study cohort, we found that a higher GRFS mHAg load was associated with a protective effect against relapse ( p=0.009) and conferred a benefit in 2-year overall survival ( p=0.03). Furthermore, HLA class I immunopeptidome analysis of 5 AML cell lines revealed evidence of presentation for 10 epitopes predicted from genes in the overall GvL filter, two of which were also part of the GRFS mHAg set. Given the limited size and lack of ethnic diversity of our discovery cohort (composed mainly of patients of European ancestry), we used genomic data from the 1000 Genomes project to estimate the feasibility of targeting our GRFS mHAg set in a broader population via in silico modeling of allo-HSCT. We simulated 2270 D-R pairs from 844 individuals across 5 populations of disparate ancestry (AFR, EAS, EUR, SAS, and AMR), mirroring a typical URD search in the NMDP registry. To gauge the feasibility of generating personalized mHAg-specific immunotherapy (i.e. cancer vaccines, adoptive cellular therapy) based on the GRFS mHAg set, we estimated that a 10-SNP design (i.e., the number of GRFS SNPs used for correlative analyses in our discovery cohort) would be possible for ~90% of the 1000 Genomes simulated cohort (EUR: 99%, EAS: 72%, SAS: 91%, AFR: 69%, AMR: 74%). Through a similar process, we calculated population coverage simulating a T cell-based approach targeting ≥1 epitope from the GRFS mHAg set. First, we identified 18 HLA alleles that could ensure ~99% coverage across diverse ethnic backgrounds. Second, for each HLA allele, the 3 most frequently predicted (and with highest agretopicity) epitopes from the GRFS SNP set were selected, defining a pool of 54 epitopes. We thus calculated that ≥1 epitopes could be potentially targeted for 81% of the simulated D-R pairs (EUR: 91%, EAS: 78%, SAS: 71%, AFR: 62%, and AMR:85%). Overall, we developed a robust approach to identify novel GvL mHAgs, which could form the basis for systematic personalized immunotherapy following allo-HSCT.
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Sousa, Albertina Antonielly Sydney de, Sâmela Abreu e. Santiago, Rafaela Soares Carvalho, Marcília Cavalcante Araújo, Emanuele Rodrigues Melo e Kariane Gomes Cezario Roscoche. "Avaliação da qualidade de vida no trabalho de Docentes de Graduação em Enfermagem". ARCHIVES OF HEALTH INVESTIGATION 9, n.º 6 (13 de outubro de 2020): 601–8. http://dx.doi.org/10.21270/archi.v9i6.4975.
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Introdução: No âmbito do Ensino Superior é importante conhecer o nível de Qualidade de Vida no Trabalho dos docentes para que realizem suas atividades de forma saudável e produtiva, contribuindo para a excelência do processo de ensino-aprendizagem. Objetivo: Avaliar a qualidade de vida no trabalho de docentes do curso de Enfermagem de uma Instituição de Ensino Superior de Fortaleza-CE. Métodos: Estudo exploratório-descritivo, quantitativo, realizado com 27 docentes. Os dados foram coletados em maio e junho de 2017 utilizando o Quality of Working Life Questionnaire-78, analisados estatisticamente e discutidos com base na literatura. Resultados: O perfil docente constituiu-se majoritariamente de enfermeiras jovens, doutoras e exercendo dupla jornada de trabalho. Todos os domínios da Qualidade de Vida no Trabalho avaliados classificaram-se como satisfatórios, sendo os domínios Físico/Saúde e Profissional os de menores pontuações (61,17 e 65,09, respectivamente), e o domínio Pessoal o de maior pontuação (76,54). Como sugestões dos docentes para melhorar a Qualidade de Vida no Trabalho, citaram-se: realização de ginástica laboral; maior tempo para planejar e produzir as atividades docentes; implantação de espaços para relaxamento; redução das cargas horárias e maior investimento em capacitações. Conclusão: A qualidade de vida no trabalho deve ser considerada na dimensão subjetiva dos indivíduos, pois se estende à sua vida pessoal e é diretamente influenciada pela organização do processo laboral. Logo, é importante que os gestores identifiquem elementos que reforcem positivamente o desempenho dos colaboradores no ambiente de trabalho.
Descritores: Trabalho; Qualidade de Vida; Instituições de Ensino Superior; Educação em Enfermagem; Docentes de Enfermagem.
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Broyl, Annemiek, Rowan Kuiper, Martin H. van Vliet, Erik H. van Beers, Yvonne de Knegt, Bronno van der Holt, Laila el Jarari et al. "Prognostic Impact of Genetic Subgroups and Development of Gene Classifiers for Response, PFS and OS In Multiple Myeloma Patients Treated with Bortezomib or Conventional Agents In HOVON65/GMMG-HD4 Trial". Blood 116, n.º 21 (19 de novembro de 2010): 445. http://dx.doi.org/10.1182/blood.v116.21.445.445.
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Abstract Abstract 445 Background. In newly diagnosed myeloma patients, bortezomib treatment induces high rates of complete response (CR) and very good partial response (VGPR). Recently, we published the clustering of gene expression profiles in 320 MM patients, who were included in a large prospective, randomized, phase III transplantation trial with bortezomib (PAD) versus conventional vincristine (VAD) based induction treatment (HOVON65/GMMG-HD4). We identified 12 distinct subgroups CD-1, CD-2, MF, MS, PR, HY, LB, Myeloid, including three novel defined subgroups NFκB, CTA, and PRL3 and a subgroup with no clear gene expression profile (NP). Aim. To look at the prognostic impact of these 12 clusters in the trial and group clusters together into a high risk (HR) and low risk (LR) group in the different treatment arms. Furthermore, to define a high risk signature to identify the patients at increased risk of disease progression. Methods. Gene expression profiles of myeloma cells obtained at diagnosis of 320 HOVON65/GMMG-HD4 patients were available. Response, progression free survival (PFS) and overall survival (OS) data were available for the first 628 patients, resulting in analysis of gene expression in relation to prognosis in 229 patients. The prognostic impact of the genetic subgroups separately and grouped into high and low risk were evaluated using Kaplan Meier and Cox regression analysis using exhaustive search (R). For the high risk gene signature the HOVON65 gene expression data was used as training set with PFS as outcome measure. Two independent myeloma datasets with survival data were used as an external validation, UAMS (GSE2658) and APEX (GSE9782)). The signature was generated by a Cox proportional hazard model in combination with LASSO (Least Absolute Shrinkages and Selection Operator) for simultaneous parameter estimation and variable selection using the R package glmnet. ISS stage was implemented by adjusting the individual covariant penalization factors of the LASSO. Results. The highest CR+nCR rates were found in the PRL3 and NP clusters, i.e. 78% and 86%, respectively (VAD), and 100% (PAD). The lowest CR+nCR rate was 17% in the CD1 cluster (PAD) and 0% in the CD2, MF and PR clusters (VAD). Based on the impact of clusters on PFS and OS in the VAD arm, the MS, MF, PR and CTA clusters were included into a High Risk (HR) group. This HR group showed a median PFS of 13 months and OS of 21 months vs. the Low Risk (LR) group consisting of the remainder of clusters with a median PFS of 31 months and a median OS not reached (P<.001).In contrast, in the PAD arm, only the PR cluster conferred a poor prognosis and exclusively formed the HR group, showing a median PFS of 12 months and OS of 13 months vs. the LR groups consisting of the remainder of clusters with a median PFS of 32 months and a median OS not reached (P=.004). In the poor prognostic subgroup MF, a striking difference in outcome on PAD vs. VAD was observed, i.e. 24 vs. 3 months (PFS) and 39 vs. 4 months (OS), respectively. In the multivariate analysis, including the covariates recurrent translocations, 17p deletion, 13q loss, LDH and ISS stage, the HR group definition remained independent poor prognostic indicators for both treatment arms. A LASSO-based high-risk signature was generated (48 probe sets). External validation was performed in the data sets UAMS TT2 and APEX. In both studies, the high-risk signature identified a high-risk population of 13% with highly significant log rank p-values (7.7*10−8 and 4.2*10−9, respectively). Combination of all validation data, n=615, corrected for type of treatment and study, resulted in an overall Cox proportional hazard model's hazard ratio of 3.8 with p <2*10−16. Conclusion. Distinctive gene expression clusters affect prognosis, which differ depending on treatment. In the conventional treatment arm (VAD), MS, MF, PR and CTA clusters confer a worse prognosis while with bortezomib based treatment, only the PR cluster affects prognosis negatively. These HR groups remain independent poor prognostic indicators. Based on the HOVON65/GMMG-HD4 study population, a high-risk signature was generated with strong and highly significant predicting ability in two independent data sets. Disclosures: Mulligan: Millenium: Employment. Goldschmidt:Celgene: Membership on an entity's Board of Directors or advisory committees; Ortho Biotech: Membership on entity's Board of Directors or advisory committees; Ortho Biotech: Research Funding; Celgene: Research Funding; Chugai Pharma: Research Funding; Amgen: Research Funding. Sonneveld:Ortho Biotech: Research Funding; International Myeloma Foundation: Research Funding; Ortho Biotech: Consultancy.
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Trisysty, Sal Shabia Azura, e Atina Shofawati. "FAKTOR-FAKTOR YANG MEMPENGARUHI KEPEMILIKAN SAHAM PADA KELUARGA MUSLIM DI INDONESIA". Jurnal Ekonomi Syariah Teori dan Terapan 9, n.º 1 (30 de janeiro de 2022): 1. http://dx.doi.org/10.20473/vol9iss20221pp1-13.
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ABSTRAK Lingkungan rumah tangga keluarga merupakan tempat pertama kali kita menghadapi persoalan ekonomi. Ketidakpastian ekonomi di satu sisi meningkatkan permintaan akan perencanaan keuangan. Penelitian ini akan berfokus pada mencari tahu faktor-faktor mikro keluarga muslim di Indonesia yang dapat mempengaruhi keputusan investasi khususnya saham. Penelitian ini menerapkan metode kuantitatif dengan instrumen data sekunder Indonesia Family Life Survey (IFLS) gelombang 5. Teknik analisis data yang digunakan adalah analisis regresi probit, teknik analisis yang dilakukan dalam regresi probit meliputi; uji kelayakan model, analisis koefisien determinasi (R2), dan uji hipotesis. Berdasarkan hasil penelitian ditemukan bahwa variabel variabel jumlah keluarga, pinjaman, usia, dan status pernikahan tidak berpengaruh secara signifikan terhadap probabilitas kepemilikan saham. Adapun variabel pendapatan, tingkat pendidikan, jenis kelamin dan financial worship memiliki hubungan positif dan signifikan terhadap probabilitas kepemilikan saham pada keluarga muslim di Indonesia. Diharapkan penelitian ini dapat bermanfaat bagi Otoritas Jasa Keuangan dan Bursa Efek Indonesia sebagai informasi tambahan dan bahan pertimbangan dalam pembenahan kebijakan mengenai peningkatan literasi manajemen keuangan keluarga dan kesejahteraan masyarakat di Indonesia.Kata Kunci: Kepemilikan Saham, Pendapatan, Tingkat Pendidikan, Jumlah Tanggungan Keluarga, Pinjaman, Usia, Jenis Kelamin, Status Pernikahan, Financial Worship. ABSTRACTThe family home environment is the first place we face economic problems. Economic uncertainty on the one hand increases the demand for financial planning. This study will focus on finding out the micro factors of Muslim families in Indonesia that can influence investment decisions, especially stocks. This study applies quantitative methods with secondary data instruments Indonesia Family Life Survey (IFLS) wave 5 The data analysis technique used is probit regression analysis, the analysis techniques carried out in probit regression include; model feasibility test, analysis of the coefficient of determination (R2), and hypothesis testing. Based on the results of the study, it was found that the variables of family size, loan, age, and marital status did not significantly influence the probability of stock ownership. The variables of income, education level, gender and financial worship have a positive and significant relationship to the probability of stock ownership in Muslim families in Indonesia. It is hoped that this research can be useful for the Otoritas Jasa Keuangan and the Bursa Efek Indonesia as additional information and consideration in reforming policies regarding increasing literacy in family financial management and community welfare in Indonesia.Keywords: Stock Ownership, Income, Education Level, Number of Dependents in the Family, Loans, Age, Gender, Marital Status, Financial Worship. DAFTAR PUSTAKAAhmed, H. (2016). Inclusive Islamic financial planning: A conceptual framework. International Journal of Islamic and Middle Eastern Finance and Management, 9(2), 170–180. https://doi.org/10.1108/mf.2008.00934jaa.001Anshori, M., & Iswati, S. (2009). Metode penelitian kuantitatif, edisi 1. Surabaya: Airlangga University Press.Badan Pengembangan dan Pembinaan Bahasa Kemendikbud RI. (2016). Kamus Besar Bahasa Indonesia. Jakarta: Kemendikbud RI.Badan Pusat Statistik. (n.d.). Jumlah anggota rumah tangga. 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A., Nasir, A., Anang, Z., & Alipiah, R. M. (2018). Determinants of muslim household basic needs consumption expenditures. Jurnal Ekonomi Malaysia, 52(1), 309–323. https://doi.org/10.17576/jem-2018-5201-23Suwardi, A. (2011). Modul stata: LPM, logit, dan probit model. Depok: Lab Komputasi Departemen Ilmu Ekonomi FEUI.Syahrial, M. (2011). Anakku maukah kau jadi pengusaha? Jakarta: Lentera Ilmu Cendekia.Wu, S., & Shen, W. (2017). The relationship between credit constraints and household risky assets. 1–23. Retrieved from http://www.diva-portal.org/smash/get/diva2:1127991/FULLTEXT01.pdfYao, R., & Hanna, S. D. (2005). The effect of gender and marital status on financial risk tolerance. Journal of Personal Finance, 4(1), 66–85.
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Cortes, Jorge E., H. Jean Khoury, Hagop M. Kantarjian, Jeff H. Lipton, Dong-Wook Kim, Maureen G. Conlan, Eric Leip, Kathleen Turnbull, Tim H. Brümmendorf e Carlo Gambacorti-Passerini. "Bosutinib As Therapy For Chronic Phase Chronic Myeloid Leukemia Following Failure With Imatinib Plus Dasatinib and/Or Nilotinib: 36-Month Update". Blood 122, n.º 21 (15 de novembro de 2013): 4025. http://dx.doi.org/10.1182/blood.v122.21.4025.4025.
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Abstract Bosutinib (BOS) is an oral dual Src/Abl tyrosine kinase inhibitor (TKI). This open-label, phase 1/2 study evaluated BOS in patients (pts) with chronic phase chronic myeloid leukemia (CP CML) following TKI failure. Pts (n=118) aged ≥18 y with prior imatinib (IM) failure plus dasatinib (D) resistance (D-R; n=38) or intolerance (D-I; n=50), nilotinib (N) resistance (N-R; n=26), or N-I or D-R/I + N-R/I (n=4) received BOS starting at 500 mg/d. Median (range) age was 56 (20–79) y; time from CML diagnosis was 6.6 (0.6–18.3) y; follow-up duration was 33.1 (0.3–84.8) mo; BOS treatment duration was 8.5 (0.2–78.1) mo. Escalation to BOS 600 mg/d occurred in 21 (18%) pts. For the last enrolled pt, time from first dose was ≥36 mo; 19% are still receiving BOS. Confirmed complete hematologic response (CHR) was newly attained or maintained from baseline by 73% of pts (Table). Major cytogenetic response (MCyR) was attained/maintained by 40% of pts (32% with complete cytogenetic response [CCyR]). Kaplan-Meier probability of maintaining CHR or MCyR at 3 y was 65%.IM + D-R (n=38)IM + D-I (n=50)IM + N-R (n=26)IM + N-I or D-R/I + N-R/Ia (n=4)Total (n=118)Evaluable,b n3849254116Confirmed CHR, n (%)26 (68)37 (76)19 (76)3 (75)85 (73)Probability of maintaining CHR at 3 yc57%74%62%NR65%Evaluable,b n3645254110MCyR, n (%)14 (39)19 (42)9 (36)2 (50)44 (40)CCyR , n (%)8 (22)18 (40)7 (28)2 (50)35 (32)Probability of maintaining MCyR at 3 yc29%87%75%NR65%Treated, n3850264118PD/death at 3 yd26%16%35%NR25%OS at 2 yc80%83%92%NR84%D=dasatinib; I=intolerant; IM=imatinib; N=nilotinib; NR=not reported (small sample size); OS=overall survival; PD=progressive disease; R=resistant.aIncludes 3 pts with prior exposure to all 3 TKIs and 1 N-I pt.bReceived ≥1 BOS dose and had a valid baseline efficacy assessment for the respective endpoint.cBased on KM estimates.dBased on cumulative incidence adjusting for competing risk of treatment discontinuation without PD or death. Of 85 pts with known baseline mutation status, 19 unique BCR-ABL mutations occurred in 39 (46%) pts, including 7 (8%) with T315I. Responses were seen across mutations, but were low in pts with T315I (29% CHR; 14% MCyR). In pts with ≥1 mutation, excluding T315I, 75% had CHR and 40% had MCyR. 38 pts had known baseline and end of treatment mutation status; 8/38 had ≥1 new mutation (V299L, n=4; T315I, n=2; F359C, G250E, L248V, n=1 each); 7/8 discontinued BOS due to disease progression or lack of efficacy. Cumulative incidence of on-treatment transformation to accelerated-phase (AP) CML at 3 y was 4%; 77% discontinued without transformation. No pt transformed to blast-phase (BP); no transformations occurred after 2 y. Cumulative incidence of on-treatment progression (transformation to AP/BP CML, increasing white blood cell count [doubling over ≥1 mo with 2nd count >20×109/L and confirmed ≥1 wk later], or loss of confirmed CHR or unconfirmed MCyR) or death at 3 y was 25%; 55% of pts discontinued without an event. Overall survival (OS) at 2 y was 84% (Table; 3-y OS estimates unreliable; pts followed for OS for only 2 y after BOS discontinuation]). Overall, 96 (81%) pts discontinued treatment, the most common primary reasons were adverse event (AE; n=29 [25%]), disease progression (n=25 [21%]), or unsatisfactory efficacy (n=23 [19%]). 26 (22%) deaths occurred on study, 5 within 30 d of last BOS dose. Most deaths were due to disease progression (n=11 [9%]) or AE (n=11 [9%], including 1 death reported as treatment-related due to lower gastrointestinal bleeding). 4 deaths had unknown cause 33–615 d after the last BOS dose. Non-hematologic treatment-emergent AEs in ≥20% of pts (all grades; grade 3/4) were diarrhea (83%; 9%), nausea (48%; 1%), vomiting (38%; 1%), rash (27%; 3%), headache (26%; 3%), fatigue (23%; 2%), and abdominal pain (24%; 1%); common hematologic toxicities included thrombocytopenia (38%; 26%), neutropenia (20%; 15%), and anemia (19%; 7%). Cardiac events occurred in 15% of pts (8% grade 3/4). Grade 3/4 laboratory abnormalities in ≥10% of pts were thrombocytopenia (26%), neutropenia (20%), lymphopenia (16%), and hypermagnesemia (12%). 78 (66%) pts had ≥1 dose delay; 59 (50%) had ≥1 dose reduction. 31 (26%) pts discontinued BOS due to AE, most commonly thrombocytopenia (7%). BOS continues to demonstrate durable efficacy and manageable toxicity after ≥36 mo follow-up in CP-CML pts following resistance or intolerance to multiple TKIs. Disclosures: Cortes: Pfizer: Consultancy, Research Funding; Novartis: Research Funding; Bristol Myer Squibb: Research Funding; Teva: Consultancy, Research Funding; Ariad: Consultancy, Research Funding. Kantarjian:Pfizer Inc: Research Funding. Lipton:Novartis: Honoraria, Membership on an entity’s Board of Directors or advisory committees, Research Funding, Speakers Bureau; Bristol Myers Squib: Honoraria, Membership on an entity’s Board of Directors or advisory committees, Research Funding, Speakers Bureau; Ariad: Equity Ownership, Honoraria, Membership on an entity’s Board of Directors or advisory committees, Research Funding, Speakers Bureau; Pfizer: Honoraria, Membership on an entity’s Board of Directors or advisory committees, Research Funding, Speakers Bureau. Kim:Pfizer: Consultancy, Honoraria, Membership on an entity’s Board of Directors or advisory committees, Research Funding; Novartis: Consultancy, Honoraria, Membership on an entity’s Board of Directors or advisory committees, Research Funding; BMS: Consultancy, Honoraria, Membership on an entity’s Board of Directors or advisory committees, Research Funding. Conlan:Pfizer Inc: Employment. Leip:Pfizer Inc: Employment. Turnbull:Pfizer Inc: Employment. Brümmendorf:Ariad: Consultancy; Patent on the use of imatinib and hypusination inhibitors: Patents & Royalties; Pfizer: Consultancy, Honoraria; Novartis: Consultancy, Honoraria, Research Funding; Bristol Myers Squibb: Consultancy, Honoraria. Gambacorti-Passerini:Bristol Myer Squibb: Consultancy; Pfizer Inc: Consultancy, Research Funding; Novartis: Consultancy.
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Estrella, Soledad, e Patricia Estrella. "Representaciones de datos en estadística: de listas a tablas". Revista Chilena de Educación Matemática 12, n.º 1 (20 de abril de 2020): 21–34. http://dx.doi.org/10.46219/rechiem.v12i1.20.
Texto completo da fonteResumo:
Con el propósito de estudiar la organización de datos e identificar la diversidad de representaciones construidas en situación de exploración de datos auténticos, en un grupo de 56 estudiantes chilenos de tercer grado de primaria, se diseñó e implementó un plan de clases de estadística, en el que se solicitó a los estudiantes ordenar y organizar los datos para responder a un problema. Este artículo se centra en el estudio cualitativo de las representaciones de datos producidas por los estudiantes durante la implementación del plan de clases. La exploración de los datos realizada por los estudiantes sobre los alimentos que consumían en la escuela (“colaciones”), los llevó a elaborar representaciones de datos (listas, estado intermedio de esquema tabular y tabla de frecuencias). Se concluye que el contexto auténtico y la construcción de representaciones propias promovieron que los estudiantes construyeran preponderantemente listas (77%), aplicando con sentido la partición, la clase y el cardinal. Se sugiere incorporar explícitamente en la enseñanza el formato lista, como herramienta representacional y unidad básica de la tabla. Referencias Brizuela, B., y Alvarado, M. (2010). First graders' work on additive problems with the use of different notational tools. Revista IRICE, 21, 37-43. Recuperado a partir desde https://ojs.rosario-conicet.gov.ar/index.php/revistairice/article/view/v21n21a04 Brizuela, B., y Lara-Roth, S. (2002). Additive relations and function tables. Journal of Mathematical Behavior, 20(3), 309-319. https://doi.org/10.1016/S0732-3123(02)00076-7 Coutanson, B. (2010). La question de l’éducation statistique et de la formation de l’esprit statistique à l’école primaire en France. Étude exploratoire de quelques caractéristiques de situations inductrices d’un enseignement de la statistique au cycle III (Tesis doctoral). Université de Lyon, Francia. Recuperado desde https://tel.archives-ouvertes.fr/tel-00494338/ Dibble, E. (1997). The Interpretation of Tables and Graphs. Seattle, WA: University of Washington. Duval, R. (2003). Comment Analyser le Fonctionnement Representationnel des Tableaux et leur Diversite? Spirale -Revue de Recherches en Éducation-, 32, 7-31. Recuperado desde http://spirale-edu-revue.fr/IMG/pdf/1_Duval_Spi32F.pdf Estrella, S. (2014). El formato tabular: una revisión de literatura. Revista Actualidades Investigativas en Educación, 14(2), 1-23. Estrella, S., e Isoda, M. (2020). Suma Primero: manual del docente, 1° básico. Valparaíso: Ediciones Universitarias de Valparaíso. Estrella, S., Mena-Lorca, A., y Olfos, R. (2017). Naturaleza del objeto matemático “Tabla”. Magis: Revista Internacional de Investigación en Educación, 10(20), 105-122. https://doi.org/10.15517/aie.v14i2.14817 Estrella, S., Olfos, R., Morales, S., y Vidal-Szabó, P. (2017). Argumentaciones de estudiantes de primaria sobre representaciones externas de datos: componentes lógicas, numéricas y geométricas. Revista Latinoamericana de Investigación en Matemática Educativa, 20(3), 345-370. https://doi.org/10.12802/relime.17.2034 Estrella, S., Olfos, R., Vidal-Szabó, P., Morales, S., y Estrella, P. (2018). Competencia meta-representacional en los primeros grados: representaciones externas de datos y sus componentes. Revista Enseñanza de las Ciencias, 36(2), 143-163. https://doi.org/10.5565/rev/ensciencias.2143 Estrella, S., Zakaryan, D., Olfos, R., y Espinoza, G. (2020). How teachers learn to maintain the cognitive demand of tasks through Lesson Study. Journal of Mathematics Teacher Education, https://doi.org/10.1007/s10857-018-09423-y Friel, S. N., Curcio, F. R., y Bright, G. W. (2001). Making sense of graphs: Critical factors influencing comprehension and instructional implications. Journal for Research in Mathematics Education, 124-158. https://psycnet.apa.org/doi/10.2307/749671 Gabucio, F., Martí, E., Enfedaque, J., Gilabert, S., y Konstantinidou, A. (2010). Niveles de comprensión de las tablas en estudiantes de primaria y secundaria. Cultura y Educación, 22(2), 183-197. https://doi.org/10.1174/113564010791304528 Kaufman, E. L., Lord, M. W., Reese, T. W., y Volkmann, J. (1949). The discrimination of visual number. The American journal of psychology, 62(4), 498-525. Lehrer, R., y Schauble, L. (2000). Inventing data structures for representational purposes: Elementary grade students' classification models. Mathematical Thinking and Learning, 2(1-2), 51-74. https://psycnet.apa.org/doi/10.1207/S15327833MTL0202_3 Martí, E. (2009). Tables as cognitive tools in primary education. En C. Andersen, N. Scheuer, M. Pérez Echeverría, y E.V. Teubal (Coord.), Representational systems and practices as learning tools (pp. 133-148). Rotterdam: Sense Publishers. Martí, E., García-Mila, M., Gabucio, F., y Konstantinidou, K. (2010). The construction of a double-entry table: a study of primary and secondary school students’ difficulties. European Journal of Psychology of Education, 26(2), 215-234. www.jstor.org/stable/23883606 Martí, E., Pérez, E., y De la Cerda, C. (2010). Alfabetización gráfica. La apropiación de las tablas como instrumentos cognitivos. Contextos, 10, 65-78. Martínez, M., y Brizuela, B. (2006). A third grader’s way of thinking about linear function tables. Journal of Mathematical Behavior, 25, 285-298. https://doi.org/10.1016/j.jmathb.2006.11.003 Ministerio de Educación de Chile. (2018). Bases Curriculares Primero a Sexto Básico. Santiago de Chile: Unidad de Currículum y Evaluación, Ministerio de Educación de Chile. Recuperado desde https://www.curriculumnacional.cl/614/articles-22394_bases.pdf Moore, D. S., y Cobb, G. W. (2000). Statistics and mathematics: Tension and cooperation. The American Mathematical Monthly, 107(7), 615-630. Nisbet, S., Jones, G., Thornton, C., Langrall, C., y Mooney, E. (2003). Children’s Representation and Organisation of Data. Mathematics Education Research Journal, 15(1), 42-58. https://doi.org/10.1007/BF03217368 Pérez-Echeverría, M., y Scheuer, N. (2009). External Representations as Learning Tools: An Introduction. En C. Andersen, N. Scheuer, M. Pérez-Echeverría, y E. Teubal (Eds.), Representational systems and practices as learning tools (pp. 1-17). Rotterdam: Sense Publishers. Pfannkuch, M., y Rubick, A. (2002). An exploration of students’ statistical thinking with given data. Statistics Education Research Journal, 1(2), 4-21. https://iase-web.org/documents/SERJ/SERJ1(2).pdf Sepúlveda, A., Díaz-Levicoy, D., y Jara, D. (2018). Evaluación de la comprensión sobre Tablas Estadísticas en estudiantes de Educación Primaria. Bolema: Boletim de Educação Matemática, 32(62), 869-886. http://dx.doi.org/10.1590/1980-4415v32n62a06 Tukey, J. (1977). Exploratory data analysis. Reading, MA: Addison-Wesley. Wu, H., y Krajcik, J. (2006). Inscriptional Practices in Two Inquiry-Based Classrooms: A Case Study of Seventh Graders’ Use of Data Tables and Graphs. Journal of Research in Science Teaching, 43(1), 63-95. https://doi.org/10.1002/tea.20092 Financiamiento: Esta investigación se ha realizado dentro del proyecto subvencionado por Agencia Nacional de Investigación y Desarrollo (ANID) / FONDECYT 1200346 y Proyecto VRIE-PUCV 039.439/2020
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Fitria Budi Utami. "The Implementation of Eating Healthy Program in Early Childhood". JPUD - Jurnal Pendidikan Usia Dini 14, n.º 1 (30 de abril de 2020): 125–40. http://dx.doi.org/10.21009/141.09.
Texto completo da fonteResumo:
Eating habits develop during the first years of a child's life, children learn what, when, and how much to eat through direct experience with food and by observing the eating habits of others. The aim of this study is to get a clear picture of the Eating program Healthy, starting from the planning, implementation, supervision, and evaluation as a case study of nutrition education; to get information about the advantages, disadvantages and effects of implementing a healthy eating program for children. This research was conducted through a case study with qualitative data analysed using Miles and Huberman techniques. Sample of children in Ananda Islāmic School Kindergarten. The results showed the Healthy Eating program could be implemented well, the diet was quite varied and could be considered a healthy and nutritious food. The visible impact is the emotion of pleasure experienced by children, children become fond of eating vegetables, and make children disciplined and responsible. Inadequate results were found due to the limitations of an adequate kitchen for cooking healthy food, such as cooking activities still carried out by the cook himself at the Foundation's house which is located not far from the school place; use of melamine and plastic cutlery for food; the spoon and fork used already uses aluminium material but still does not match its size; does not involve nutritionists.
Keywords: Early Childhood, Eating Healthy Program
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Unusan, N. (2007). Effects of a food and nutrition course on the self-reported knowledge and behavior of preschool teacher candidates. Early Childhood Education Journal, 34(5), 323– 327. https://doi.org/10.1007/s10643-006-0116-9
Usfar, A. A., Iswarawanti, D. N., Davelyna, D., & Dillon, D. (2010). Food and Personal Hygiene Perceptions and Practices among Caregivers Whose Children Have Diarrhea: A Qualitative
Study of Urban Mothers in Tangerang, Indonesia. Journal of Nutrition Education and Behavior, 42(1), 33–40. https://doi.org/10.1016/j.jneb.2009.03.003
Witt, K. E., & Dunn, C. (2012). Increasing Fruit and V egetable Consumption among Preschoolers: Evaluation of Color Me Healthy. Journal of Nutrition Education and Behavior, 44(2), 107–113. https://doi.org/10.1016/j.jneb.2011.01.002
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ÇETİNKAYA, Ali, e Özlem HASKAN AVCI. "OKULDA KENDİNİ TOPARLAMA GÜCÜ: BİR ÖLÇEK UYARLAMA ÇALIŞMASI". Türk Psikolojik Danışma ve Rehberlik Dergisi, 3 de junho de 2023. http://dx.doi.org/10.17066/tpdrd.1245904ao.
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This study aimed to adapt the School Resilience Scale (Caleon& King, 2020) to Turkish culture. The participants of this study were high school students. The study consisted of three stages. The first stage regarded the scale translation for linguistic equivalence. In the second stage, the structural validity and reliability of the scale were tested. In the third stage, a test-retest reliability of the scale was performed. Fifty-three students (52.8% girls) participated in the first group, 615 students (52.7% girls) in the second group, and 88 students (67% girls) in the third group. The confirmatory factor analysis (CFA) findings to test construct validity showed that the four-factor structure of the scale had an excellent fit index. Next, a two-level confirmatory factor analysis was conducted, which confirmed the two-level model. The Cronbach's Alpha reliability coefficient for the total scale was .89, while it was between .78 and .84 for the sub-dimensions of the scale. In sum, the findings evidenced that the school resilience scale was a valid and reliable measurement tool that can be used to assess Turkish high school students' school resilience.
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Hussain, Ibrahim, Benjamin R. Hartley, Lily McLaughlin, Anne S. Reiner, Ilya Laufer, Mark H. Bilsky e Ori Barzilai. "Surgery for Metastatic Spinal Disease in Octogenarians and Above: Analysis of 78 Patients". Global Spine Journal, 20 de outubro de 2021, 219256822110379. http://dx.doi.org/10.1177/21925682211037936.
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Study Design: Retrospective Cohort Study. Objective: Octogenarians living with spinal metastases are a challenging population to treat. Our objective was to identify the rate, types, management, and predictors of complications and survival in octogenarians following surgery for spinal metastases. Methods: A retrospective review of a prospectively collected cohort of patients aged 80 years or older who underwent surgery for metastatic spinal tumor treatment between 2008 and 2019 were included. Demographic, intraoperative, complications, and postoperative follow-up data was collected. Cox proportional hazards regression and logistic regression were used to associate variables with overall survival and postoperative complications, respectively. Results: 78 patients (mean 83.6 years) met inclusion criteria. Average operative time and blood loss were 157 minutes and 615 mL, respectively. The median length of stay was 7 days. The overall complication rate was 31% (N = 24), with 21% considered major and 7% considered life-threatening or fatal. Blood loss was significantly associated with postoperative complications (OR = 1.002; P = 0.02) and mortality (HR = 1.0007; P = 0.04). Significant associations of increased risk of death were also noted with surgeries with decompression, and cervical/cervicothoracic index level of disease. For deceased patients, median time to death was 4.5 months. For living patients, median follow-up was 14.5 months. The Kaplan-Meier based median overall survival for the cohort was 11.6 months (95% CI: 6.2-19.1). Conclusions: In octogenarians undergoing surgery with instrumentation for spinal metastases, the median overall survival is 11.6 months. There is an increased complication rate, but only 7% are life-threatening or fatal. Patients are at increased risk for complications and mortality particularly when performing decompression with stabilization, with increasing intraoperative blood loss, and with cervical/cervicothoracic tumors.
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LABAJO-VILLANTES, YUNALYN, JIM COOTES, YI-BO LUO e OLGA M. NUNEZA. "Orchid diversity across different forest types on Mt. Malindang, Philippines". Biodiversitas Journal of Biological Diversity 25, n.º 2 (19 de fevereiro de 2024). http://dx.doi.org/10.13057/biodiv/d250219.
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Abstract. Labajo-Villantes Y, Cootes J, Luo Y-B, Nuneza OM. 2024. Orchid diversity across different forest types on Mt. Malindang, Philippines. Biodiversitas 25: 605-615. Mt. Malindang Range Natural Park is one of the most significant biodiversity and conservation areas and is considered a biodiversity hotspot. There have been many biodiversity studies on Mt. Malindang, but information on orchid taxonomy and distribution is limited. This study aimed to conduct a comprehensive inventory of orchids using an exploratory method. Samplings were conducted in different forest types: montane, mossy, dipterocarp, mixed dipterocarp, and almaciga. A total of 114 orchid species with 55 endemics were recorded. Three of these (Phalaenopsis x intermedia Lindl., Paphiopedilum hennisianum (M.W.Wood) Fowlie, and Paphiopedilum haynaldianum (Rchb.f.) Stein) were under Appendix I (can only be exported under specific circumstances). At the same time, 78 were under the Appendix II (follow controlled trades) categories of the Convention on International Trade in Endangered Species of Wild Fauna and Flora. P. hennisianum and P. haynaldianum, listed as endangered species globally, were observed in montane and mossy forests, respectively. Among the six sampling sites, the montane forest was the most species-rich, with the most endemics, followed by the mossy forest. Almaciga and mixed dipterocarp forests were closely related with 100% similarity. The results of this study are valuable to Mt. Malindang's ecological profile for more effective protection and conservation plans.
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Honda, Mitsuhiko, Ryo Tazaki, Koji Murakawa, Hiroshi Terada, Tomoyuki Kudo, Takashi Hattori, Jun Hashimoto, Motohide Tamura e Makoto Watanabe. "Subaru/IRCS L-band spectro-polarimetry of the HD 142527 disk scattered light". Publications of the Astronomical Society of Japan, 14 de junho de 2022. http://dx.doi.org/10.1093/pasj/psac041.
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Abstract Spatially resolved L-band spectro-polarimetric observations were carried out toward a protoplanetary disk around the Herbig Fe star HD 142527 using the polarimetry mode of the InfraRed Camera and Spectrometer on the 8.2 m Subaru Telescope. The 2.9–4.1 μm polarimetric spectra of the bright central source and the scattered light at a distance of ${0{^{\prime \prime}_{.}}78}$ from the center toward the PA ∼ 290° were obtained using the AO188 adaptive optics system. The polarization spectra of the central region show no significant evidence of the polarization which is expected with the (non-aligned) hot dust emission near the central star, while the disk scattered light spectra shows linear polarization of $\sim\!\! 10\%$, which is consistent with the nature of scattered light. In addition, the polarization PA of ∼20° is also geometrically consistent with the scattered light from the central region. We also derived the flux density spectra of each region and confirmed the 3 μm water-ice absorption feature in the scattered light spectra, which is consistent with the findings in Honda et al. (2009, ApJ, 690, L110). By comparing the model predictions by Tazaki et al. (2021b, ApJ, 921, 173), we estimated the grain properties of the extracted disk region. Assuming the power-law size distribution of silicate and ice, the maximum grain size amax of 3 μm and fractional ice abundance relative to Pollack et al. (1994, ApJ, 421, 615) (fice) of ∼0.1 is inferred, which is consistent with the finding by Tazaki et al. ( 2021b, ApJ, 921, 173).
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Fried, Ruby L., Micah B. Hahn, Patricia Cochran e Laura P. Eichelberger. "“Remoteness was a blessing, but also a potential downfall”: Traditional/Subsistence and store-bought food access in remote Alaska during the COVID-19 pandemic". Public Health Nutrition, 18 de abril de 2023, 1–23. http://dx.doi.org/10.1017/s1368980023000745.
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Abstract Objective: This study employs a strengths-based approach to assess food access in remote Alaska during the COVID-19 pandemic, identifying both the negative consequences of the pandemic on store-bought and subsistence/traditional food access as well as compensatory strategies used. Design: As a part of a larger study on the impacts of COVID-19 on daily life remote Alaska communities, study data presented here were collected through key informant interviews (KIIs) and statewide online surveys from September 21, 2020 to March 31, 2021 among remote Alaska community members. Setting: This study was conducted with residents of remote communities in Alaska, defined as those off of the road system. Remote communities often have small or no grocery stores, and rely on subsistence or traditional sources of food. Participants: KII participants (n=36) were majority female (78%) and Alaska Native (57%). Survey participants (n=615) were also majority female, 25-54 years old, and most had had some post-secondary education or training. Results: Survey and interview data revealed that the pandemic had significant negative impacts on store-bought food access in remote Alaskan communities. Individuals also shared that locally available and wild harvested foods acted as a buffer to some of the loss of access to these store-bought foods, with some people sharing that the harvesting of wild and traditional foods served served as a coping strategy during times of pandemic-related stress. Conclusions: The results from this study demonstrate that the remoteness of some Alaska communities has been both a source of vulnerability and protection in terms food access.
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Hoeh, Benedikt, Mike Wenzel, Olivia Eckart, Felicia Fleisgarten, Cristina Cano Garcia, Jens Köllermann, Christoph Würnschimmel et al. "Comparison of peri- and intraoperative outcomes of open vs robotic-assisted partial nephrectomy for renal cell carcinoma: a propensity-matched analysis". World Journal of Surgical Oncology 21, n.º 1 (22 de junho de 2023). http://dx.doi.org/10.1186/s12957-023-03061-2.
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Abstract Background Partial nephrectomy (PN) is the gold standard surgical treatment for resectable renal cell carcinoma (RCC) tumors. However, the decision whether a robotic (RAPN) or open PN (OPN) approach is chosen is often based on the surgeon’s individual experience and preference. To overcome the inherent selection bias when comparing peri- and postoperative outcomes of RAPN vs. OPN, a strict statistical methodology is needed. Materials and methods We relied on an institutional tertiary-care database to identify RCC patients treated with RAPN and OPN between January 2003 and January 2021. Study endpoints were estimated blood loss (EBL), length of stay (LOS), rate of intraoperative and postoperative complications, and trifecta. In the first step of analyses, descriptive statistics and multivariable regression models (MVA) were applied. In the second step of analyses, to validate initial findings, MVA were applied after 2:1 propensity-score matching (PSM). Results Of 615 RCC patients, 481 (78%) underwent OPN vs 134 (22%) RAPN. RAPN patients were younger and presented with a smaller tumor diameter and lower RENAL-Score sum, respectively. Median EBL was comparable, whereas LOS was shorter in RAPN vs. OPN. Both intraoperative (27 vs 6%) and Clavien-Dindo > 2 complications (11 vs 3%) were higher in OPN (both < 0.05), whereas achievement of trifecta was higher in RAPN (65 vs 54%; p = 0.028). In MVA, RAPN was a significant predictor for shorter LOS, lower rates of intraoperative and postoperative complications as well as higher trifecta rates. After 2:1 PSM with subsequent MVA, RAPN remained a statistical and clinical predictor for lower rates of intraoperative and postoperative complications and higher rates of trifecta achievement but not LOS. Conclusions Differences in baseline and outcome characteristics exist between RAPN vs. OPN, probably due to selection bias. However, after applying two sets of statistical analyses, RAPN seems to be associated with more favorable outcomes regarding complications and trifecta rates.
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De Rycker, Johan, Carrie Ruxton, Markus Jungen e Ralf Schweiggert. "Nutritional composition of commercially-produced 100% orange juice reveals large variability in vascular health bioactive, hesperidin". Proceedings of the Nutrition Society 79, OCE2 (2020). http://dx.doi.org/10.1017/s0029665120002682.
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AbstractIt is well-accepted that fruits contain a wide array of nutrients and bioactive substances which may contribute towards the prevention of chronic disease. Citrus fruits, as well as their juices, are recognised for their rich polyphenol content, specifically the flavanones; hesperidin, naringin and narirutin. Citrus fruits and juices are also rich in vitamin C and provide a source of folate, potassium and provitamin A.Randomised controlled trials have reported significant improvements to vascular function and blood pressure following consumption of 100% orange juice (OJ) with the effects potentially mediated through hesperidin and/or potassium (which has an EU claim for supporting normal blood pressure). Further clinical research may be facilitated by up-to-date information on the composition of OJ.By auditing more than 350 fruit processing companies worldwide, the non-profit organisation SGF International collects authentic OJ samples for regular compliance testing. Samples of unpasteurized OJ from the production line are removed by trained staff immediately post-extraction and frozen at -18°C within a few minutes. The samples are posted in this state to accredited laboratories where key nutrients and bioactives are tested. SGF's Database of Authentic Samples (2018) provides the following data (mg/litre) as sample size, mean, standard deviation, minimum, maximum for hesperidin (231, 520, 175, 109, 1160), L-ascorbic acid (615, 450, 98, 120, 721), potassium (1242, 1758, 204, 1197, 2340), total carotenoids (575, 7, 3, 2, 21) and pectins (1043, 334, 132, 19, 932).On average, there was more hesperidin in OJ than vitamin C, giving an estimated composition of 78 mg hesperidin and 67.5 mg vitamin C per 150 mL serving. Samples from Chinese producers had the greatest variability in hesperidin (109–1160 mg/L) while samples from Argentina, South Africa and Spain had the smallest variability. When OJ from not-from-concentrate (n = 62) and concentrate (n = 169) were compared, mean levels of hesperidin were significantly higher in the not-from-concentrate juice (576 mg/L [sd 228 mg/L] vs. 500 mg/L [sd 146 mg/L]; P = 0.016; Welch's t-test).Vascular benefits in humans have been detected at OJ intakes of 500 ml/day or hesperidin intakes of 290 mg/day (Morand et al. 2011). From a quality assurance perspective, the AIJN sets an acceptable range for hesperidin as 250–700mg/L. Raising the upper cut-off could increase the hesperidin content of commercially-available OJ with potential benefits for vascular health.Morand C et al. (2011) Am J Clin Nutr 93: 73–80.
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Tamborrino, P. P., V. Barletta, A. Parlato, M. Parollo, L. Mazzocchetti, S. Sbragi, A. Canu et al. "Feasibility and outcomes of Micra implant after cardiac implantable electronic device extraction". Europace 25, Supplement_1 (24 de maio de 2023). http://dx.doi.org/10.1093/europace/euad122.362.
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Abstract Funding Acknowledgements Type of funding sources: None. Background The specific and well-known design features of leadless pacing system (Micra Transcatheter Pacing System, M-TPS) have suggested his use in patients that previously underwent transvenous lead extraction (TLE) for any reason. The study aimed to investigate feasibility and long-term outcomes of M-TPS implant in patients underwent TLE. Methods Patients undergone M-TPS implantation in our Institution from May 2014 to September 2022 were included in the study. All patients fulfilled standard criteria for PM implantation (VVI or VDD mode). Follow-up (FU) was scheduled at discharge, after 1 month and every 6 months thereafter and electrical parameters were checked. Major complications were defined as life-threatening events, requiring surgical intervention or any event causing significant hemodynamic instability or resulting in death. Study population was divided between "naïve pacing" and "post-extraction" patients. Results We enrolled 193 patients (76.7% males), 57 (29.5%) received M-TPS implantation after TLE, needed because of infection in 91.4% of cases. Indications for pacing were permanent AF with bradycardia in 107 (55.5%) patients, complete AVB in 59 (30.5%), symptomatic sinus node dysfunction in 20 (10%), and advanced AVB or bifascicular bock in 7 (4%). There were no statistically significant differences between groups for demographics characteristics and primary PM implant indications, except mean age at implant that was significantly inferior in the post-extraction group [80 (IQR 75-84) vs 78 (IQR 72-83), p=0.04]. Implant procedure was successful in all and no complications were recorded. No differences between groups in procedure duration [40 (IQR 30-50) vs 45 (30-65) min, p=0.34], fluoroscopy time [9 (6-14) vs 9 (6-11) min, p=0.31] and single device delivery (64.9% vs 67.9%, p=0.35) were observed. The mean FU was 12 (1-36) months, maximum 8 years. Pacing variables at implantation [pacing threshold 0.5 (0.38-0.63) vs 0.5 (0.38-0.88) V/0.24 ms, p=0.15; impedance 720 (600-837) vs 675 (615-825) Ohm, p=0.51; R wave amplitude 9 (6.25-12.87) vs 8.2 (5.65-12) mV, p=0.47], discharge [pacing threshold 0.38 (0.38-0.63) vs 0.38 (0.38-0.63) V/0.24 ms, p=0.27; impedance 685 (580-770) vs 610 (560-750) Ohm, p=0.16; R wave amplitude 10.25 (7.2-14.5) vs 9.3 (6.5-16.5) mV, p=0.6], and at 6 months [pacing threshold 0.5 (0.38-0.5) vs 0.5 (0.38-1.25) V/0.24 ms, p=0.64; impedance 580 (520-680) vs 570 (510-640) Ohm, p=0.63; R wave amplitude 11.9 (8.2-16.4) vs 11.7 (9-20) mV, p=0.68; battery voltage 3.09 (3.05-3.11) vs 3.09 (3.04-3.13) V, p=0.71] did not show differences. Conclusion M-TPS is an efficacious and safe alternative to conventional PM, with the main advantage of the absence of transvenous leads and a surgically created subcutaneous pocket, avoiding all the related complications. These devices are a reliable alternative after TLE, with similar electrical performances than those observed in patients who did not previously received pacing.