Literatura científica selecionada sobre o tema "4-azaindazole"
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Artigos de revistas sobre o assunto "4-azaindazole"
Faarasse, Soukaina, Saïd El Kazzouli, Otmane Bourzikat, Stéphane Bourg, Samia Aci‐Sèche, Pascal Bonnet, Franck Suzenet e Gérald Guillaumet. "Palladium‐Catalyzed Regioselective C−H Arylation of 4‐Azaindazole at C3, C5 and C7 Positions". Advanced Synthesis & Catalysis 363, n.º 16 (19 de março de 2021): 3937–45. http://dx.doi.org/10.1002/adsc.202001421.
Texto completo da fonteFaarasse, Soukaina, Saïd El Kazzouli, Otmane Bourzikat, Stéphane Bourg, Samia Aci‐Sèche, Pascal Bonnet, Franck Suzenet e Gérald Guillaumet. "Front Cover Picture: Palladium‐Catalyzed Regioselective C−H Arylation of 4‐Azaindazole at C3, C5 and C7 Positions (Adv. Synth. Catal. 16/2021)". Advanced Synthesis & Catalysis 363, n.º 16 (26 de julho de 2021): 3867. http://dx.doi.org/10.1002/adsc.202100859.
Texto completo da fonteAlam, Ryan M., e John J. Keating. "“Walking the nitrogen around the ring”: Chemical synthesis and spectroscopic characterization of novel 4‐, 5‐, 6‐, and 7‐azaindazole analogs of the synthetic cannabinoid receptor agonist MDMB‐PINACA". Drug Testing and Analysis 14, n.º 2 (11 de novembro de 2021): 277–97. http://dx.doi.org/10.1002/dta.3180.
Texto completo da fonteSwift, Elizabeth C., Zachary S. Sales, Dongpei Wu, Anastassia Matviitsuk, Daniel J. Pippel e Terry P. Lebold. "Synthesis of Highly Functionalized 4-Iodo-7-azaindazoles via Condensation/Diels–Alder/Retro-Diels–Alder Cyclization of Iodoalkynones and 2-Hydrazineylpyrimidines". Organic Letters, 22 de novembro de 2023. http://dx.doi.org/10.1021/acs.orglett.3c03481.
Texto completo da fonteZheng, Lei, Zulihuma Aimaiti, Lu Long, Chuang Xia, Wenya Wang e Zhong-Zhen Zhou. "Discovery of 4-Ethoxy-6-chloro-5-azaindazoles as Novel PDE4 Inhibitors for the Treatment of Alcohol Use Disorder and Alcoholic Liver Diseases". Journal of Medicinal Chemistry, 29 de dezembro de 2023. http://dx.doi.org/10.1021/acs.jmedchem.3c02087.
Texto completo da fonteTeses / dissertações sobre o assunto "4-azaindazole"
Nassiri, Sarah. "Fonctionnalisations régiosélectives de N-oxyde de pyrazolopyridines via des réactions de C-H activation pallado-catalysées". Electronic Thesis or Diss., Orléans, 2024. https://theses.univ-orleans.fr/prive/accesESR/2024ORLE1007_va.pdf.
Texto completo da fonteThe activation of C-H bonds has emerged as an attractive approach for advancing the synthesis of novel heterocyclic systems with potential applications across diverse fields, particularly in biology and pharmacy.The primary aim of this PhD thesis was to develop innovative strategies for the selective functionalization of nitrogen-containing heterocycles through C-H activation reactions, employing transition metal catalysis.In the first part, we developed a synthesis methodology enabling the regioselective functionalization at the ortho position of the N-oxide function in 7-azaindazole derivatives. The reaction goes through anoxidative arylation reaction, with various arenes and heteroarenes as coupling partners. This approachenables precise control over the position of functionalization through optimized reaction conditions, which is crucial to design new compounds with enhanced properties whatever the domains of application.In the second part of our research, we conducted a series of experiments to perform a regioselectiveoxidative alkenylation on the pyridine moiety of 4-azaindazole and 7-azaindazole. Using the N-oxidefunction as an ortho directing group allowed us to exert control over the position of functionalization.In the last part, we presented our work aimed at establishing optimal conditions for a direct arylation reaction on various 7-azaindazole analogues. The use of the N-oxide function favoured the regioselectivity of the reaction towards the C6 position