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Artigos de revistas sobre o assunto "341.4/8"
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Mosyichuk, L. M., O. M. Tatarchuk, O. V. Simonova e O. P. Petishko. "Features of cytokine balance with the progression of structural changes in the gastric mucosa in patients with atrophic gastritis". GASTROENTEROLOGY 55, n.º 2 (23 de junho de 2021): 67–73. http://dx.doi.org/10.22141/2308-2097.55.2.2021.233625.
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Background. Until now, the issue of the correlation between the cytokine balance and the progression of structural changes in the gastric mucosa remain completely uncertain. At the same time, the determination of the role of cytokine balance as a component of gastric carcinogenesis will make it possible to substantiate new approaches to managing patients with atrophic gastritis. The purpose was to assess the level of pro- and anti-inflammatory cytokines, vascular endothelial growth factor (VEGF) at the stages of progression of structural changes in the gastric mucosa of patients with atrophic gastritis. Materials and methods. The study included 79 individuals with atrophic gastritis who underwent narrow band imaging endoscopic examination. The patients were divided into groups taking into account the revealed structural changes in the gastric mucosa: group I — 7 people with gastric mucosal atrophy without intestinal metaplasia (IM); group II — 16 individuals with gastric mucosal atrophy with IM limited by the antrum; group III — 45 people with diffuse IM against the background of gastric mucosal atrophy; group IV — 10 individuals with gastric mucosal dysplasia. In all patients, we assessed the level of interleukins (IL-8, IL-10, IL-18), tumor necrosis factor alpha (TNF-α), VEGF. Results. In patients of group IV, the concentration of IL-8 in the blood serum was 18.6 (11.3; 23.9) pg/ml that was significantly higher than in group I (by 5.0 times, p < 0.05), group II (by 3.6 times, p < 0.05) and group III (by 3.4 times, p < 0.05). According to the results of the Kruskal-Wallis test, the probability of a difference in the IL-8 level between the groups was 0.0260. The level of VEGF in the blood serum of patients with gastric mucosal dysplasia was significantly increased compared to that in people with gastric mucosal atrophy without IM (by 1.8 times, p < 0.05) and those with gastric mucosal atrophy with IM (by 1.7 times, p < 0.05). Changes in the cytokine balance towards proinflammatory cytokines were most pronounced in patients of groups III and IV; according to the results of the Kruskal-Wallis test, the probability of a difference in the IL-8/IL-10 ratio between the groups was 0.0207. Conclusions. With the progression of structural changes in the gastric mucosa of patients with atrophic gastritis, an increase in the level of proinflammatory cytokines (IL-8, IL-18 and TNF-α) in the blood serum does not induce the secretion of anti-inflammatory cytokines (IL-10). According to the results of the ROC analysis, the diagnostic criteria for the formation of the risk group for detecting dysplastic changes in the gastric mucosa are VEGF level of more than 341.4 mU/ml (sensitivity — 90.0 %, specificity — 77.2 %) and the level of IL-8 above 14.4 pg/ml (sensitivity — 80.0 %, specificity — 78.3 %).
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Koutsos, Athanasios, Samantha Riccadonna, Maria M. Ulaszewska, Pietro Franceschi, Kajetan Trošt, Amanda Galvin, Tanya Braune et al. "Two apples a day lower serum cholesterol and improve cardiometabolic biomarkers in mildly hypercholesterolemic adults: a randomized, controlled, crossover trial". American Journal of Clinical Nutrition 111, n.º 2 (16 de dezembro de 2019): 307–18. http://dx.doi.org/10.1093/ajcn/nqz282.
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ABSTRACT BACKGROUND Apples are rich in bioactive polyphenols and fiber. Evidence suggests that consumption of apples or their bioactive components is associated with beneficial effects on lipid metabolism and other markers of cardiovascular disease (CVD). However, adequately powered randomized controlled trials are necessary to confirm these data and explore the mechanisms. OBJECTIVE We aimed to determine the effects of apple consumption on circulating lipids, vascular function, and other CVD risk markers. METHODS The trial was a randomized, controlled, crossover, intervention study. Healthy mildly hypercholesterolemic volunteers (23 women, 17 men), with a mean ± SD BMI 25.3 ± 3.7 kg/m2 and age 51 ± 11 y, consumed 2 apples/d [Renetta Canada, rich in proanthocyanidins (PAs)] or a sugar- and energy-matched apple control beverage (CB) for 8 wk each, separated by a 4-wk washout period. Fasted blood was collected before and after each treatment. Serum lipids, glucose, insulin, bile acids, and endothelial and inflammation biomarkers were measured, in addition to microvascular reactivity, using laser Doppler imaging with iontophoresis, and arterial stiffness, using pulse wave analysis. RESULTS Whole apple (WA) consumption decreased serum total (WA: 5.89 mmol/L; CB: 6.11 mmol/L; P = 0.006) and LDL cholesterol (WA: 3.72 mmol/L; CB: 3.86 mmol/L; P = 0.031), triacylglycerol (WA: 1.17 mmol/L; CB: 1.30 mmol/L; P = 0.021), and intercellular cell adhesion molecule-1 (WA: 153.9 ng/mL; CB: 159.4 ng/mL; P = 0.028), and increased serum uric acid (WA: 341.4 μmol/L; CB: 330 μmol/L; P = 0.020) compared with the CB. The response to endothelium-dependent microvascular vasodilation was greater after the apples [WA: 853 perfusion units (PU), CB: 760 PU; P = 0.037] than after the CB. Apples had no effect on blood pressure or other CVD markers. Conclusions These data support beneficial hypocholesterolemic and vascular effects of the daily consumption of PA-rich apples by mildly hypercholesterolemic individuals. This trial was registered at clinicaltrials.gov as NCT01988389.
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Dedy Pratama, Hendro Sudjono Yuwono, Rudi Supriyadi, Herry Herman, Fachreza Aryo Damara e Avicenna Akbar. "Antioxidant Properties of Curcumin and Its Impact on Arteriovenous Fistula Maturation in End-Stage Kidney Disease Patient with Diabetes Mellitus Type 2". International Journal of Research in Pharmaceutical Sciences 11, n.º 4 (25 de dezembro de 2020): 7624–29. http://dx.doi.org/10.26452/ijrps.v11i4.4107.
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The risk of maturation failure in arteriovenous fistula (AVF) remains high. Curcumin poses antioxidant effects may enhance AVF maturation. This study evaluates the antioxidant effect of Curcumin on AVF maturation among type 2 diabetic patients (T2DM) with end-stage renal disease (ESRD). This was a single-blinded, randomized controlled trial conducted in three tertiary hospitals in Jakarta, Indonesia. Patients underwent the first hemodialysis. A total of 67 patients divided into groups of Curcumin, acetylsalicylic acid, and placebo. After 4 weeks, TAC level among the curcumin group was significantly higher compared to acetylsalicylic acid, and placebo groups 794.2(457.4±1473.7) µM vs. 519.2(247.7 ± 1027.7) µM and 794.2(457.4± 1473.7) µM vs. 542.5(281.91± 1054.64) µM, respectively (p<0.05). Also, TAC after 8 weeks was significantly higher among curcumin group compared to acetylsalicylic acid, and placebo groups (820.5(380.7± 1643.7) µM vs. 509.7(341.0± 981.91) µM and 820.5(380.7± 1643.7) µM vs. 497.7(324.7± 979.2) µM, respectively (p<0.001). The TAC level patients with mature AVF were also higher. A 2000 mg/day of curcumin increases antioxidant capacity after 4 and 8 weeks following AVF surgery among ESRD with T2DM.
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Rahman, Md Hashibur, Mohammad Ashraful Alam, Flura, Md Moniruzzaman, Sharmin Sultana, Anik Talukdar e Md Rakibul Islam. "Effects of substituting plant-based protein sources for fish meal in the diet of Nile Tilapia (Oreochromis niloticus)". Archives of Agriculture and Environmental Science 8, n.º 3 (25 de setembro de 2023): 333–38. http://dx.doi.org/10.26832/24566632.2023.080309.
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The purpose of this study was to evaluate the nutritional adequacy and suitability of rice polish and mustard oil cake as protein sources in the diet of Nile Tilapia (Oreochromis niloticus). To assess the growth performance and feed utilization of Nile Tilapia, three diets containing rice polish (0, 8, and 16%) and mustard oil cake (8, 16, and 24%) were formulated and fed to the fish over a period of 60 days. According to the findings, the growth performance tended to decline as the levels of rice polish and mustard oil cake increased. The control diet (30% Fish meal) resulted in the highest weight gain (373.79±49.78%), whereas the diet (20% Fish meal) resulted in the least weight gain (341.24±27.23%). The specific growth rate (SGR) followed the same pattern, and there were no statistically significant differences in SGR between diets (p>0.05). At the end of this trial, the feed intake (FI) of the various diets ranged between 32.37 g and 37.78 g per fish. Although feed conversion ratio (FCR) and protein efficiency ratio (PER) were not significantly different among diets (p>0.05), feed intake decreased as the incorporation of rice polish increased.
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Liu, Jun-Li, Alfred H. Stammers, Hong Zheng, Nancy J. Mills, Jeffery D. Nichols, Scott A. Kmiecik, Ryan J. Kohtz e Craig M. Petterson. "The Effect of Controlled Aprotinin Administration Through Cardiotomy Suction during Cardiopulmonary Bypass". Journal of ExtraCorporeal Technology 34, n.º 3 (setembro de 2002): 203–8. http://dx.doi.org/10.1051/ject/2002343203.
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Cardiotomy suction enhances inflammation and fibrinolysis during cardiopulmonary bypass (CPB). Aprotinin has been shown to reduce the generalized inflammatory insults associated with CPB. The purpose of this study was to evaluate the effect of Aprotinin administration through cardiotomy suction on the inflammatory and fibrinolytic responses during CPB. A pig model of CPB was utilized including 8 animals divided into control and treatment groups. In the treatment group, Aprotinin was infused into the cardiotomy suction (3000 KIU/min), while the same volume of saline was infused in the control group. D-dimer, platelet count, and IL-8 level were analyzed from systemic and cardiotomy suction. It was found that Aprotinin significantly suppressed the increase in D-dimer levels in the systemic (476.3 ± 341.2 vs. 1218.8 ± 281.3 ng/ml, p < 0.05) and the cardiotomy suction (565.0 ± 192.5 vs. 1875.0 ± 125.0 ng/ml, p < 0.05). Platelet count fell in both groups during CPB, although the reduction was greater in the control (13.1 ± 5.1 vs. 37.9 ± 13.8 %, p < 0.05). In addition, IL-8 level in the suction solution was significantly lower in the Aprotinin group (56.5 ± 18.0 vs. 136.3 ± 14.8 pg/ml, p < 0.05). In conclusion, this study suggested that Aprotinin treatment of the cardiotomy solution might be an effective way of reducing fibrinolysis, platelet reduction, and inflammation associated with CPB.
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Kilba, M.-C. F., S. Salie e B. Morrow. "Risk factors and outcomes of extubation failure in a South African tertiary paediatric intensive care unit". Southern African Journal of Critical Care 38, n.º 1 (6 de maio de 2022): 26–32. http://dx.doi.org/10.7196/sajcc.2022.v38i1.513.
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Background. Extubation failure contributes to poor outcome of mechanically ventilated children, yet the prevalence and risk factors have been poorly studied in South African (SA) children. Objective. To determine the prevalence, risk factors and outcomes of extubation failure in an SA paediatric intensive care unit (PICU). Methods. This was a prospective, observational study of all mechanically ventilated children admitted to a tertiary PICU in Cape Town, SA. Extubation failure was defined as requiring re-intubation within 48 hours of planned extubation. Results. There were 219 episodes of mechanical ventilation in 204 children (median (interquartile range (IQR)) age 8 (1.6 - 44.4) months). Twenty-one of 184 (11.4%) planned extubations (95% confidence interval (CI) 7.2% - 16.9%) failed. Emergency cardiac admissions (adjusted odds ratio (aOR) 7.58 (95% CI 1.90 - 30.29), dysmorphology (aOR 4.90; 95% CI 1.49 - 16.14), prematurity (aOR 4.39; 95% CI 1.24 - 15.57), and ventilation≥48 hours (aOR 6.42 (95% CI 1.57 - 26.22) were associated with extubation failure. Children who failed extubation had longer durations of ventilation (231 hours (146.0 - 341.0) v. 53 hours (21.7 - 123.0);p<0.0001); longer duration of PICU (15 (9 - 20) days v. 5 (2 - 9) days;p<0.0001) and hospital length of stay (32 (21 - 53) days v. 15 (8 - 27) days;p=0.009); and higher 30-day mortality (28.6% v. 6.7%;p=0.001) than successfully extubated children. Conclusions. Extubation failure was associated with significant morbidity and mortality in our setting. Risk factors for extubation failure identified in our context were similar to those reported in other settings.
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Tunjung-Sari, Ariza Budi, Teguh Wahyudi, Diana Chusna Mufida, Mekania Tamarizki, Desyana Perwitahati, Ihda Kartika Syamsuddin e Misnawi Jati. "Use of cocoa ethanolic extract for treatment of Staphylococcal infection in rabbit-skin model". Pelita Perkebunan (a Coffee and Cocoa Research Journal) 32, n.º 1 (30 de abril de 2016): 34–42. http://dx.doi.org/10.22302/iccri.jur.pelitaperkebunan.v32i1.214.
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In septic condition, the skin normal flora Staphylococcal spp. may trigger local and sistemic skin infection. In this study antibacterial activity of cocoa ethanolic extract (CEE) against Staphylococcus aureus and Staphylococcus epidermidis infections was observed in vitro and in vivo. Ethanolic extract from unfermented cocoa beans was prepared as solution in the in vitro testing, while for in vivo testing the extract was prepared as cream. Agar well diffusion assay showed that CEE ranging from 7.8 mg/mL to 1000 mg/mL demonstrated inhibitory activity against growth of either S. aureus and S. epidermidis. Inhibitory activity of CEE was in concentration dependent manner, and was less potential than either cephalexin 4 x 10 -3 mg/mL or cefotaxime 8 x 10 -3 mg/mL. Linear regression of CEE concentration plotted against inhibition zone values ha dpredicted the minimum inhibitory concentrations (MIC) of CEE towards S. aureus and S. epidermidis were at 341.9 mg/mL and 359.7 mg/mL, respectively. Topical application of cream containing CEE at several concentrations (2%, 4%, and 8%) demonstrated healing properties towards incision wound infected with S. aureus and S. epidermidis cultures in rabbit-skin model. CEE cream promoted wound contraction and higher recovery rate than of base cream (negative control) but lower than mupirocin 2% cream. In S. aureus and S. epidermidis infected wound models, CEE cream 8% improved wound recovery to 72.7% and 86.1% from original rates of 23.5% and 34.7% (base cream application). Catechin and procyanidis are suggested playing roles in alleviation of wound inflammation and stimulation of extracellular matrix accumulation, thus accelerate the wound healing process. This study proposes utilization of cocoa bean as source of active ingredient for skin care products.
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Al-Gharawi, Firas Abdul Karim Makki, Hamza Nouri Al-Dulaimi e Naim Shteiwi Matar. "Effect of Adding Different Levels of Potassium on Some Vegetative Growth Characteristics of Maize Under Water Stress Conditions". IOP Conference Series: Earth and Environmental Science 1262, n.º 5 (1 de dezembro de 2023): 052054. http://dx.doi.org/10.1088/1755-1315/1262/5/052054.
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Abstract A field experiment was conducted for the autumn season in 2022 in an agricultural land in the province of Raranjia (Hamzawiyah), 10 km south of Babylon Governorate, the center of Hilla, in soil with sandy clay mixed texture to improve the growth efficiency of the Maize plants (Zea mays L.) Fajr 1 cultivar under water stress conditions by the effect of irrigation durations and the addition of different amounts of potassium sulfate. The experiment was designed in randomized complete block design (R.C.B.D) with three replicates. in a split - plots arrangement, as the irrigation periods included four levels, namely irrigation every (6, 8, 10 and 12) days as a main factor, while potassium sulfate included four levels (0, 150, 200 and 250) kg.h-1. The results achieved the duration of irrigation every 8 days significant superiority in the average on the highest, leaf area, leaves content of chlorophyll and the dry matter of plant, which amounted to 177.8 cm, 519.3 cm 2, 47.9 SPAD and 428.5 g, while the duration of irrigation every 12 days was significantly reduced in reducing some vegetative growth characteristics, as the average yield of dry matter reached 341.9 g and the level of potassium sulfate added significantly affected the increase in vegetative of growth indicators such as plant height, leaf area, dry weight and leaf content of chlorophyll, and the potassium level of 250 kg.h-1 achieved the highest values among other potassium levels for the same traits, reaching 180.3 cm, 522.9 cm2, 432.1 g and 47.9 SPAD respectively, while the interaction between the two factors had a significant impact on most of the studied traits and gave interference Irrigation periods 8 days and potassium addition 250 kg.ha -1.
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Rathod, Sapna M., e Paresh U. Patel. "Development and Validation for Simultaneous Estimation of Sofosbuvir and Daclatasvir Dihydrochloride in Pharmaceutical Dosage form by Ratio Derivative and Dual Wavelength Methods". International Journal of Pharmaceutical Quality Assurance 11, n.º 01 (25 de março de 2020): 25–31. http://dx.doi.org/10.25258/ijpqa.11.1.4.
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Development and validation of new simple, sensitive, accurate and precise spectrophotometric method involving ratio derivative and dual-wavelength method, was done as per ICH Q2 (R1) for simultaneous estimation of Sofosbuvir (SOFO) and daclatasvir dihydrochloride (DACLA) in a combined dosage form. The overlapping in the spectra of both drugs was the reason for the selection of both methods. The absorbance difference (ΔA) value between 235.8 nm and 270.6 nm was selected for the quantitative determination of SOFO, where DACLA gives equal absorbance at the selected wavelength in the dual-wavelength method (Method A). The determination of DACLA is done quantitatively by measuring the difference in absorbance value at 249 nm and 268.6 nm where SOFO gives equal absorbance at a selected wavelength. Ratio spectra method (Method B) was based on dividing the spectra of a mixture with standard spectra of one of the analytes, and the first derivative spectra was recorded with Δλ = 8 nm and scaling factor 1. The amount of SOFO and DACLA was estimated in the binary mixtures by computing the first derivative signal at 247.0 nm and 341.0 nm, respectively. The calibration curve was linear in the concentration range of 10–90 μg/mL for SOFO and 4–20 μg/mL for DACLA for both the methods. The methods were successfully applied for the simultaneous determination of these drugs in combined dosage form with acceptable recoveries.
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Stein, Sebastian, Marcel Kersting, Lukas Heletta e Rainer Pöttgen. "Rare earth-ruthenium-magnesium intermetallics". Zeitschrift für Naturforschung B 72, n.º 6 (24 de maio de 2017): 447–55. http://dx.doi.org/10.1515/znb-2017-0048.
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AbstractEight new intermetallic rare earth-ruthenium-magnesium compounds have been synthesized from the elements in sealed niobium ampoules using different annealing sequences in muffle furnaces. The compounds have been characterized by powder and single crystal X-ray diffraction. Sm9.2Ru6Mg17.8 (a=939.6(2), c=1779(1) pm), Gd11Ru6Mg16 (a=951.9(2), c=1756.8(8) pm), and Tb10.5Ru6Mg16.5 (a=942.5(1), c=1758.3(4) pm) crystallize with the tetragonal Nd9.34Ru6Mg17.66 type structure, space group I4/mmm. This structure exhibits a complex condensation pattern of square-prisms and square-antiprisms around the magnesium and ruthenium atoms, respectively. Y2RuMg2 (a=344.0(1), c=2019(1) pm) and Tb2RuMg2 (a=341.43(6), c=2054.2(7) pm) adopt the Er2RuMg2 structure and Tm3Ru2Mg (a=337.72(9), c=1129.8(4) pm) is isotypic with Sc3Ru2Mg. Tm3Ru2Mg2 (a=337.35(9), c=2671(1) pm) and Lu3Ru2Mg2 (a=335.83(5), c=2652.2(5) pm) are the first ternary ordered variants of the Ti3Cu4 type, space group I4/mmm. These five compounds belong to a large family of intermetallics which are completely ordered superstructures of the bcc subcell. The group-subgroup scheme for Lu3Ru2Mg2 is presented. The common structural motif of all three structure types are ruthenium-centered rare earth cubes reminicent of the CsCl type. Magnetic susceptibility measurements of Y2RuMg2 and Lu3Ru2Mg2 samples revealed Pauli paramagnetism of the conduction electrons.