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Steen, R. W. J. "The effect of milk substitute input during calfhood on the lifetime performance of beef cattle". Animal Science 52, n.º 1 (fevereiro de 1991): 67–74. http://dx.doi.org/10.1017/s0003356100005699.
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ABSTRACTThree randomized-block experiments involving 87 British Friesian, 18 Simmental × Friesian and 18 Hereford × Friesian, artificially reared calves (mean initial live weight 47 kg and age 9 days), were carried out to examine the effects of the quantity of milk substitute consumed on the lifetime performance of beef cattle. The three treatments were (1) 400 g milk powder per head daily, weaned at 42 days of age (2) ad libitum intake of milk powder, weaned at 42 days and (3) ad libitum intake of milk powder, weaned at 60 days. All calves were individually penned and fed until after weaning; those on treatment 1 were bucket fed twice daily, while those on treatments 2 and 3 sucked the milk from 25·1 containers through artificial teats. They were offered a pelleted, barley/soya-bean meal concentrate (197 g crude protein per kg dry matter (DM)) ad libitum from purchase until intake reached a maximum of 2·7 kg per head daily, and well preserved grass silage ad libitum from 6 weeks of age. Three commercial, skimmed milk-based, acidified milk substitutes (242 and 187 g crude protein and oil per kg respectively) were used. Intakes of milk substitute, concentrate DM and silage DM per calf to 12 weeks of age for treatments 1 to 3 respectively were as follows: 13·0, 39·7 and 54·8 (s.e. 1·67) kg; 88, 73 and 58 (s.e. 1·5) kg and 9·4, 10·6 and 11·2 (s.e. 0·23) kg. Live-weight gains to 12 weeks of age and carcass weights adjusted to 19 months of age were 0·71, 0·82 and 0·84 (s.e. 0·026) kg/day and 335, 340 and 341 (s.e. 3·8) kg. It is concluded that increasing the input of milk substitute above 400 g per head daily until 6 weeks of age produced only a small and uneconomic increase in the lifetime performance of beef cattle.
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Franciscato, Suzana Janson, Guilherme Janson, Rachel Machado, José Roberto Pereira Lauris, Silvana Marques Javarez de Andrade e Mauro Fisberg. "Impact of the nutrition education Program Nutriamigos® on levels of awareness on healthy eating habits in school-aged children". Journal of Human Growth and Development 29, n.º 3 (12 de dezembro de 2019): 390–402. http://dx.doi.org/10.7322/jhgd.v29.9538.
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Introduction: With the increase of childhood obesity, early intervention in nutrition education becomes necessary. Therefore, during the school period, the school becomes the best place for implementation of a nutritional education program.
Objective: The current study was carried out in a public and in a private school, with the objective of evaluating and comparing the results of the "Nutriamigos®" Program on food and nutrition knowledge of children with different socioeconomic levels, sex, age and Body Mass Index (BMI).
Method: Comparative longitudinal study, before and after educational intervention. To evaluate the intervention, a public (school 1) and a private school (school 2) were selected. This was a random, convenience sample comparing students from different social and economic levels, consisting of 242 (school 1) and 99 children (school 2), respectively, totaling 341 children, from 6 to 10 years of age. The Body Mass Index was used to measure nutritional status. Knowledge about food and nutrition was evaluated through a questionnaire, applied before and after intervention. The nutritional intervention consisted of 12 classes of 50 minutes each.
Results: The improvement in knowledge on food and nutrition between the pre and post intervention stages was statistically significant.
Conclusion: The "Nutriamigos®" Program reached its goal, demonstrating that it is effective in public and private schools and should not be differentiated for boys or girls, or for children with normal or excessive weight.
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Jia, Yumin, Cangjue Nima, Linsheng Yang, Li Wang, Binggan Wei, Yonghua Li, Hairong Li et al. "Selenium and Zinc Intakes of Staple Grains and Their Correlation with Urine Selenium and Zinc in the Tibetan Rural Residents along the Yarlung Zangbo River". Nutrients 15, n.º 8 (21 de abril de 2023): 2010. http://dx.doi.org/10.3390/nu15082010.
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Grains account for a large proportion of the diet of rural residents in Tibet. The lack of selenium (Se) and zinc (Zn) threatens the population’s nutrition and health. However, the intakes of selenium and zinc in grains remains unclear. To clarify the nutritional status of selenium and zinc consumed from staple grains of residents along the Yarlung Zangbo River in Tibet, 341 grain samples and 242 urine samples were collected, and 244 food frequency questionnaires were completed along the Yarlung Zangbo River in 2020–2021. The results showed that the selenium concentrations of 88.5% of self-produced tsampa and 80.8% of self-produced flour were lower than the grain selenium threshold (<25 μg·kg−1). The intake of selenium and zinc from staple grains (tsampa, flour, and rice) contributed 15.0% and 43.5% to the recommended nutrient intake (RNI) on average, respectively. A geographical detector model analyzed factors affecting urinary selenium and zinc levels. Selenium and zinc intakes in rice and flour, and dietary diversity score (DDS) were the main factors affecting urinary selenium and zinc (p < 0.01). Their interaction effects on urinary selenium and zinc were greater than those of a single factor. The staple grains of rural residents along the Yarlung Zangbo River were in a state of selenium deficiency. The zinc content of the staple grain purchased was lower than that of the main grain produced by rural residents. Changing the grain consumption pattern and adjusting the proportion of exogenous grains can improve selenium and zinc nutrition in residents.
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Thongtip, Uten. "LAND USE INDICES FROM SMMS DATA IN WESTERN THAILAND". CBU International Conference Proceedings 4 (21 de setembro de 2016): 505–8. http://dx.doi.org/10.12955/cbup.v4.804.
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This applied research was conducted by employing both quantitative and qualitative innovative research methods. This research investigates the satellite data of four spectral bands sent from the Small Multi-Mission Satellite (SMMS). Each band was analyzed to create color composition indices of the western areas of Thailand. Band 1 had a wavelength between 0.43 and 0.52 micrometers, Band 2 between 0.52 and 0.60 micrometers, Band 3 between 0.63 and 0.69 micrometers, and Band 4 between 0.76 and 0.90 micrometers. Three layers of satellite data were overlaid in non-repeating arrangements. Bands showing grayscale were substituted by three additive primary colors of blue, green, and red. The arrangements were permutated into 24 indices: 123, 124, 132, 134, 142, 143, 213, 214, 231, 234, 241, 243, 312, 314, 321, 324, 341, 342, 412, 413, 421, 423, 431, and 432. The data of color composition indices were then analyzed to create the land-use indices. The visual interpretation of the three levels of land-use classification were used in this procedure. The result was a land-use classification with 15 indices: City, Commercial, and Services; Airport; Golf Course; Paddy Field; Field Crop; Perennial; Aquacultural Land; Shrimp Farm; Evergreen Forest; Deciduous Forest; Mangrove Forest; Marine; River; Canal; Reservoir; and Road.
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Kinoshita, Tomohiro, Tomomitsu Hotta, Taro Shibata, Kiyoshi Mukai, Motoko Yamaguchi, Kunihiro Tsukasaki, Yoshitoyo Kagami, Masaharu Kasai, Kensei Tobinai e Masanori Shimoyama. "Peripheral T-Cell Lymphoma-Unspecified (PTCL-U) and NK/T-Cell Lymphoma Showed a Significantly Poor Prognosis in a Randomized Controlled Trial (RCT) JCOG9002 with Multidrug Combination Chemotherapy for Aggressive Lymphoma." Blood 108, n.º 11 (1 de novembro de 2006): 2465. http://dx.doi.org/10.1182/blood.v108.11.2465.2465.
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Abstract PURPOSE: To elucidate clinical features of NHL subtyped with WHO classification, and to evaluate the prognostic impact of WHO classification on aggressive lymphoma treated in an RCT. METHODS: JCOG9002 was an RCT comparing two multidrug combination chemotherapy regimens, LSG9 and mLSG4 (Int J Hematol 80:341, 2004). Major eligibility criteria were; previously untreated patients with intermediate- or high-grade NHL on WF (ATL, LbL and CTCL were excluded); CS I to IV except CS I in GI, thyroid, orbit, or Waldeyer; age 15–69. Tissue specimens were centrally reviewed by six hematopathologists and classified according to WHO classification of lymphoid tumors. Overall survival (OAS) and complete response rate (%CR) of each WHO category were analyzed. Multivariate analyses of prognostic factors influencing OAS were conducted. RESULTS: A total of 447 patients were registered between 1991 and 1995, and the central pathological review was conducted on 404 patients. Characteristics of the 404 pts include median (range) age 56 (18–69) years; male/female 63/37%, CS I+II/III+IV 31/69%; LDH N/>N 51/49%; PS 0+1/2–4 78/22%; No. of extranodal sites 0–1/1< 77/23%; IPI L/LI/HI/H 40/27/20/12%. Major clinical features, OAS and %CR of major types according to WHO classification are summarized in Table 1. Twelve patients with FL (G1+2) were ineligible in this study but included. Clinical features, response to treatment and prognosis of each subtypes showed distinct patterns. Besides, we found that PTCL-U and NK/T-cell lymphoma showed lower CR rate and poorer OAS, and these features were quite different from other PTCL such as AILT or ALCL. Clinical features in other subtypes were similar to previous reports (Blood89: 3909, 1997; J Clin Oncol16: 2780, 1998). Cox regression analysis with IPI and WHO classification in 366 pts without missing value revealed that PTCL-U and NK/T-cell lymphoma were significant prognostic factors independent from IPI. Hazard ratios of these subgroups vs IPI low risk DLBCL group are 2.66 (95% confidence interval: 1.58–4.48) and 3.21 (1.40–7.37). CONCLUSIONS: Patients with aggressive lymphoma subtyped according to the WHO classification who were treated in an RCT showed distinctive clinical features. PTCL-U and NK/T-cell lymphoma showed a significantly poor prognosis independent from IPI, warranting further investigations focusing on these two subtypes. Table 1 No of cases (%) % male Median age % stage III or IV % IPI HI/H %5-yr OAS % CR *Pts with missing value are excluded from the denominator. Only major subtypes are included in this table. DLBCL 242 (59.9) 61 58 63 37 55 71 FL, all grades 37 (9.2) 70 55 68 15 76 70 MCL 15 (3.7) 60 57 87 20 53 73 MZL 9 (2.2) 56 51 71 0 89 67 AILT 22 (5.4) 77 58 100 67 67 73 PTCL-U 23 (5.7) 65 51 83 38 22 43 ALCL 10 (2.5) 70 50 70 33 70 70 NK/T 10 (2.5) 80 52 70 25 40 40
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Polkovnikov, Igor S., Viktoria V. Panteleeva e Anatoliy B. Shein. "Анодные процессы на Mn5Si3 –электроде в щелочном электролите". Kondensirovannye sredy i mezhfaznye granitsy = Condensed Matter and Interphases 21, n.º 1 (6 de março de 2019): 126–34. http://dx.doi.org/10.17308/kcmf.2019.21/723.
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Методами поляризационных и импедансных измерений изучено анодное поведение Mn5Si3-электрода в растворах (0.5–3.0) М NaОН в области от E коррозии до E выделения кислорода включительно. Сделан вывод, что поверхность силицида марганца в щелочном электролите обогащена металлическим компонентом сплава и продуктами его окисления. Установлены кинетические закономерности анодного поведения Mn5Si3, выяснены механизмы растворения и пассивации силицида, определены кинетические параметры реакции выделения кислорода.
ЛИТЕРАТУРА
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Agladze G. R., Kveselava V. M., Koiava N. Sh. V sb.: Elektrokhimiya margantsa [In: Manganese Electrochemistry], Tbilisi, AN GSSR Publ., 1978, vol. 7, pp. 118–126. (in Russ.)
Shein A. B., Zubova E. N. Protection of Metals, 2005, vol. 41, no. 3, pp. 234–242. https://doi.org/10.1007/s11124-005-0034-z
Nikolaichuk P. A., Shalyapina T. I., Tyurin A. G. Vestnik YuUrGU, 2010, no. 31, pp. 72–80. (in Russ.)
Okuneva T. G., Panteleeva V. V., Shein A. B. Condensed Matter and Interphases, 2016, vol. 18, no. 3, pp. 383–393. URL: http://www.kcmf.vsu.ru/resources/t_18_3_2016_009.pdf (in Russ.)
Polkovnikov S., Panteleeva V. V., Shein A. B. Vestnik Permskogo universiteta. Khimiya, 2017, vol. 7, no. 3, pp. 250–259. (in Russ.)
Sukhotin A. M., Osipenkova I. G. Zhurnal prikladnoi khimii, 1978, vol. 51, no. 4, pp. 830–832. (in Russ.)
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Polkovnikov I. S., Shaidullina A. R., Panteleeva V. V., Shein A. B. Vestnik Permskogo universiteta. Khimiya, 2018, vol. 8, no. 3, pp. 325–341. DOI: 17072/2223-1838-2018-3-325-341 (in Russ.)
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Semiadi, G., T. N. Barry, P. R. Wilson, J. Hodgson e R. W. Purchas. "Growth and venison production from red deer (Cervus elaphus) grazing red clover (Trifolium pratense) or perennial ryegrass (Lolium perenne)/white clover (Trifolium repens) pasture". Journal of Agricultural Science 121, n.º 2 (outubro de 1993): 265–71. http://dx.doi.org/10.1017/s0021859600077145.
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SUMMARYA study of growth and venison production from weaner red deer grazing pure tetraploid red clover (RC) or conventional perennial ryegrass/white clover (PRG) pasture was conducted in 1990, with the objective of attaining a minimum slaughter liveweight of 92 kg (50 kg carcass) by 12 months of age in the stags. Ten weaner red deer stags and ten weaner red deer hinds were randomly selected and rotationally grazed on either RC or PRG forage. In autumn and spring, forage allowances were 7 kgDM/hd/day and 8 kgDM/hd/day respectively. In winter, the animals from both groups were grazed together on PRG pasture, at a residual dry matter (DM) of 1100 kgDM/ha. Total nitrogen (N) concentration was higher in RC on offer than in PRG on offer (autumn 3·4 v. 3·1 %DM; spring 3·8 v. 3·1 %DM), whilst organic matter digestibility (OMD; autumn 80·5 v. 76·5%; spring 82·1 v. 80·3%) was also higher for RC on offer. Diet selected showed similar differences in total N concentration, but there were negligible differences between forages in OMD.Liveweight gains of RC and PRG stags were respectively 263 v. 192 g/day, 101 v. 106 g/day and 354 v. 341 g/day during autumn, winter and spring, with the corresponding values for hinds being 198. 173 g/day, 52 v. 53 g/day and 242 v. 218 g/day. At one year of age, stags grazing RC were 7 kg heavier and hinds 3 kg heavier than animals grazing PRG pasture. Animals grazing RC forage had higher voluntary feed intake (VFI) in both autumn (P < 0·10) and spring (P < 0·001), than animals grazing PRG pasture.All stags grazing RC forage reached the minimum slaughter liveweight by one year of age, compared to 75% of those grazing PRG pasture. At slaughter, stags that had grazed RC produced heavier carcass weights (59·9 v. 54·5 kg, P < 0·01), had higher carcass dressing percentage (55·3 v. 53·2 %; P < 0·01), and tended to have slightly greater carcass subcutaneous fat depth than stags grazing PRG pasture, but this effect disappeared when the data were corrected to equal carcass weight. All stags grazing RC produced velvet antler, relative to 75% of those grazing PRG; in stags producing harvestable velvet antler, there was no difference in antler weight between those grazing RC and PRG. It is concluded that RC offers potential as a special-purpose forage for the growth of weaner red deer.
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Bykov, Alexander D., Olga V. Naumenko, Maxim A. Smirnov, Leonid N. Sinitsa, Linda R. Brown, Joy Crisp e David Crisp. "The infrared spectrum of H2S from 1 to 5 μm". Canadian Journal of Physics 72, n.º 11-12 (1 de novembro de 1994): 989–1000. http://dx.doi.org/10.1139/p94-130.
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The absorption spectra of H2S from 2000 to 11 147 cm−1 have been obtained with spectral resolutions of 0.006, 0.012, and 0.021 cm−1 using the Fourier transform spectrometer at Kitt Peak National Observatory. The transitions of 21 bands have been assigned for the first time and 9 others reanalyzed so that accurate energy levels, band origins, and rotational parameters could be determined. The analysis of these data revealed some remarkable features in the energy spectrum, e.g., fourfold clustering of rotational levels belonging to the symmetric and asymmetric components of local mode manifolds at a high degree of stretching excitation. This paper reports fitted vibrational parameters and predicted band origins of H232S up to 12 735 cm−1. It also presents the degenerate rotational constants and upper state energies of (301)–(202) and (311)–(212) at 1 μm as illustrations of clustering in the local mode limit.
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Palma, Tarciso de Figueiredo, Sara Maria Alves Ribeiro e Vitória Maria Teixeira Santos. "A autoimagem, os transtornos mentais comuns e a depressão em estudantes de graduação". Revista de Saúde Coletiva da UEFS 10, n.º 1 (22 de dezembro de 2020): 108–15. http://dx.doi.org/10.13102/rscdauefs.v10i1.5501.
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Este estudo objetivou analisar a preocupação com a imagem corporal, os transtornos mentais comuns e a depressão. Foi realizado um estudo de corte transversal analítico e exploratório, com 117 estudantes de graduação em uma instituição do interior da Bahia. Estimou-se as prevalências das variáveis estudadas, testou-se as associações, através do qui-quadrado e foi usada a regressão logística binária para ajustes das variáveis. A ideação suicida apresentou prevalência alta (18,8%) em comparação a preocupação exagerada com a autoimagem (13,4%). As prevalências de Depressão Maior e de TMC foram, respectivamente, de 39,3% e 54,7%. Houve associação significativa com TMC para: sexo feminino (RP = 2,9; 1,5 – 5,4), realizar atividade física menos que duas vezes por semana (RP = 1,6; 1,1 – 2,3), estar desempregado (RP = 1,5; 1,1 – 2,2). Já para a depressão maior, houve significância para: realizar atividade física menos que duas vezes por semana (RP = 1,9; 1,2 – 3,1), estar desempregado (RP = 1,9; 1,2 – 3,1), ter ideias suicidas (RP = 2,1; 1,4 – 3,1) e ter preocupação exagerada com a autoimagem (RP = 2,2; 1,5 – 3,3), mesmo quando ajustado por idade e sexo (p-valor = 0,015). ABSTRACTThis study aimed to analyze the concern with body image, common mental disorders and depression. An analytical and exploratory cross-sectional study was carried out with 117 undergraduate students at an institution in the countryside of Bahia. The prevalence of the variables studied was estimated, associations were tested using the chi-square and binary logistic regression was used to adjust the variables. Suicidal ideation had a high prevalence (18.8%) in comparison to the exaggerated concern with self-image (13.4%). The prevalence of Major Depression and CMD were 39.3% and 54.7%, respectively. There was a significant association with CMD for: female gender (PR = 2.9; 1.5 - 5.4), performing physical activity less than twice a week (PR = 1.6; 1.1 - 2.3), being unemployed (PR = 1.5; 1.1 - 2.2). For major depression, there was significance for: performing physical activity less than twice a week (PR = 1.9; 1.2 - 3.1), being unemployed (PR = 1.9; 1.2 - 3, 1), having suicidal ideas (PR = 2.1; 1.4 - 3.1) and being overly concerned with self-image (PR = 2.2; 1.5 - 3.3), even when adjusted for age and gender (p-value = 0.015).
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Kirlin, P. C., M. D. Kittleson e L. E. Johnson. "Neurohumoral and cardiopulmonary response to sustained submaximal exercise in the dog". Journal of Applied Physiology 62, n.º 3 (1 de março de 1987): 1040–45. http://dx.doi.org/10.1152/jappl.1987.62.3.1040.
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Neurohumoral, cardiovascular, and respiratory parameters were evaluated during sustained submaximal exercise (3.2 km/h, 15 degrees elevation) in normal adult mongrel dogs. At the level of activity achieved (fivefold elevation of total body O2 consumption and threefold elevation of cardiac output), significant (P less than 0.05) increases in plasma norepinephrine and epinephrine concentration (from 150 +/- 23 to 341 +/- 35 and from 127 +/- 27 to 222 +/- 31 pg/ml, respectively) were present, as well as smaller but significant increases in plasma renin activity and plasma aldosterone concentration (from 2.2 +/- 0.3 to 3.1 +/- 0.6 ng X ml-1 X h-1 and from 98 +/- 8 to 130 +/- 6 pg/ml, respectively). Plasma arginine vasopressin increased variably and insignificantly. The cardiovascular response (heart rate, systemic arterial and pulmonary arterial pressures, left ventricular filling pressure, and calculated total peripheral and pulmonary arteriolar resistance) closely paralleled that of human subjects. Increased hemoglobin concentration was induced by exercise in the dogs. The ventilatory response of the animals was characterized by respiratory alkalosis. These data suggest similarities between canine and human subjects in norepinephrine, plasma renin activity, and plasma aldosterone responses to submaximal exercise. Apparent species differences during submaximal exertion include greater alterations of plasma epinephrine concentration and a respiratory alkalosis in dogs.
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Xu, Kang-zhen, Feng-qi Zhao, Feng Wang, Han Wang, Jin-an Luo e Rong-zu Hu. "Structural Characterization and Thermal Properties of 1-Amino-1-ethylamino-2,2-dinitroethylene". Chinese Journal of Chemical Physics 23, n.º 3 (junho de 2010): 335–41. http://dx.doi.org/10.1088/1674-0068/23/03/335-341.
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Akhtar, Sadaf, e Amber Ashraf. "FREQUENCY OF SUCCESSFUL THROMBOLYSIS WITH STREPTOKINASE IN PATIENTS WITH ACUTE ST ELEVATION MYOCARDIAL INFARCTION". Pakistan Heart Journal 55, Supplement1 (17 de novembro de 2022): S10. http://dx.doi.org/10.47144/phj.v55isupplement1.2426.
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Objectives: To assess the frequency of successful thrombolysis with streptokinase in patients presenting with ASTEMI within 12 hours of onset of chest pain.
Methodology: This descriptive case series was conducted at cardiology department, Khyber Teaching Hospital Peshawar during 6 months (from 16/12/2020 to 16/6/2021). In the current study a total of 340 patients were observed. Acute STEMI (as per operational definition) was interviewed through a questionnaire with special emphasis on age, presence/absence of diabetes, Troponin levels, and Electrocardiogram and echocardiogram findings consistent with the inclusion criteria. All the patients included were given Streptokinase at a dose of 1.5 million units diluted in 100 ml normal saline over 1 hour through infusion chamber. Fasting Blood glucose level were monitored every morning during admission and Post Streptokinase ECG was recorded after 30 minutes of the Streptokinase infusion. The purpose and benefits of study was explained to the patients and informed consent was obtained. With the help of above mentioned information relative risk of rate of successful thrombolysis in diabetic and non-diabetic patients was determined.
Results: Our study shows that among 340 patients mean age and standard deviation was 61± 8.19. 224(65.9%) patients were male and 116(34.1%) patients were female. More over 242(71.2%) patients had successful.
Conclusion: Our study concludes that the frequency of successful thrombolysis with streptokinase was 71% in patients presenting with ASTEMI within 12 hours of onset of chest pain.
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Schnittger, Susanne, Tamara Weiss, Claudia Haferlach, Wolfgang Kern e Torsten Haferlach. "Prognostic Impact of FLT3 Mutation Load in NPM1 Mutated AML." Blood 114, n.º 22 (20 de novembro de 2009): 826. http://dx.doi.org/10.1182/blood.v114.22.826.826.
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Abstract Abstract 826 According to the new WHO classification NPM1 mutated AML is defined as a provisional entity. Those AML without FLT3-ITD (also referred to as FLT3-LM) are regarded as prognostically favorable whereas those with detectable FLT3-ITD in addition are defined as unfavorable. However, some previous studies not taking NPM1 status into account have shown that the prognostic impact of the FLT3 mutation is highly dependent on the load of the mutation. To evaluate a possible impact of FLT3 load in NPM1 mutated AML we have quantified the FLT3 load in 641 NPM1 mutated AML.The cohort was composed of 341 females and 300 males with a median age of 65.2 years (range 17.8-88 years). The NPM1 mutation was detected by melting curve analysis whereas the FLT3-ITD was quantitatively analysed by fragment analysis (Gene Scan, 3130 sequence detection system, ABI). The FLT3-ITD load was quantified as the ratio of the mutation compared to the wildtype allele. All ratios >1 are indicative for allelic loss of the wildtype allele (wt). Overall in 242/641 (37.8%) of the NPM1 mutated AML an FLT3- ITD was detected. The length of the mutation (LM) varied between 9 and 579 bp (median: 51 bp). The ratio of FLT3- ITD was in the range between 0.016 and 44.85 (median: 0.565). Using Cox regression analysis we demonstrated that increasing FLT3-ITD/wt ratio has a significantly unfavorable influence on EFS (p=0.028) . At next, for Kaplan Meier analysis 3 groups were defined according to FLT3-ITD/wt ratio: 1) only FLT3wt (n=398); 2) FLT3-ITD/wt ratio ≤1 (n=189) and 3) FLT3-ITD/wt ratio ≥1 (n=53). It was shown that the FLT3wt group had the best median EFS of 230 days compared to 203 day in group 2 (p=0.032) and only 86 days in group 3 (p<0.001). In a next step the FLT3 ratios were further subdivided into smaller groups 1) only WT (n=398), 2) ratio <0.25 (n=63) 3) ratio > 0.25 but <0.5 (n=44); 4) ratio ≥0.5 but <1 (n=82) 5) ratio ≥1 (n=53). Although the median EFS was continuously decreasing from group 1 to 5 (230 vs 200 vs 198 vs 96 vs 86 days, respectively) a significant difference compared to the FLT3wt group was only detected for group 4 (p=0.014) and group 5 (p<0.001). This analysis demonstrated that only FLT3-ITD/wt ratios ≥0.5 led to inferior outcome in NPM1 mutated AML. The impact of the FLT3/wt ratio on overall survival (OS) could also be detected only for group 5 with a median OS of 142 days compared to 293 days in the FLT3-WT group (p<0.002) and for group 4 (median 147 days) (p=0.033), respectively. In addition other known prognostic factors were analysed for EFS: karyotype (p=0.788; n.s.), gender (p=0.042; better for female) age (p<0.001), WBC (p<0.001), FLT3-status irrespective of ratio (p=0.001) and FLT3-ITD length (p=0.002). In a multivariate analysis only age (p<0.001), WBC (p=0.001) and FLT3-ITD/wt ratio (p=0.042) came out to be independent prognostic factors in NPM1 mutated AML. For OS ratios ≥0.5 came out to be more important than FLT3 status per se (0=0.044 vs. p=0.359). Subsequently ratios '0.5 were multivariately tested against age and WBC. All three parameters came out to be of independent significance for OS (p<0.001, p=0.001, and p=0.008, respectively). In conclusion, this study clearly demonstrates that not FLT3-ITD status per se is predictive for survival in NPM1 mutated AML but ratios of FLT3-ITD load has to be taken into account. Only ratios of ≥0.5 demonstrated to have a significant impact on prognosis in NPM1 mutated AML. This data has enormous implication on clinical decision making in AML including the option of allogeneic transplantation in first CR. Disclosures: Schnittger: MLL Munich Leukemia Lab: Equity Ownership. Weiss:MLL Munich Leukemia Laboratory: Employment. Haferlach:MLL Munich Leukemia Lab: Equity Ownership. Kern:MLL Munich Leukemia Laboratory: Equity Ownership. Haferlach:MLL Munich Leukemia Laboratory: Equity Ownership.
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Aggarwal, A. K., J. Fitzpatrick e N. Aggarwal. "AB1192 RESPONSE TO VISCOSUPPLEMENTATION WITH DIFFERENT TYPES OF INTRA-ARTICULAR HYALURONIC ACIDS IN OSTEOARTHRITIS OF THE KNEE – A RETROGRADE INDIAN COHORT STUDY OF MORE THAN 15 YEARS LONGITUDINAL DATA". Annals of the Rheumatic Diseases 82, Suppl 1 (30 de maio de 2023): 1825.2–1826. http://dx.doi.org/10.1136/annrheumdis-2023-eular.2660.
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BackgroundKnee osteoarthritis (OA) is a progressive degenerative condition resulting in functional loss, pain and discomfort. [1] The current aim of treatment is alleviation of symptoms, improvement of function and joint preservation.Viscosupplementation (VS) with Intra-articular hyaluronic acid (IAHA) injection has been shown to have protective physiochemical functions and may confer disease-modifying, long term effects in OA. [2][3] However, conflicting guidelines, pooling of results for different molecular weight products, and a paucity of long-term clinical studies has resulted in lack of confidence in the results of IAHA.ObjectivesTo determine the primary and sustained response to VS with different types if IAHA in Bilateral Knee OA.To identify whether the response is different for subgroups which are:Type of IAHA,Gender - Males (M) or Females (F), andGrade of OA treated.MethodsWe did a retrospective analysis of a 15-year cohort from a single Indian centre.The inclusion criteria were adults with bilateral knee OA with functional reduction and radiological KL Grade of III and IV, treated with Non-Animal Stabilized Hyaluronic Acid (NASHA) origin IAHA injections.Subjects were stratified into two groups based on the molecular weight of the hyaluronic acid used:High Molecular Weight - 6-8 mg/ml – 6ml single injections (HMW-HA), orVery high Molecular weight – 20 mg/ml – 3 ml injections (VHMW-HA).The primary outcome measure was responder rates determined by those with improvement in total WOMAC scores of > 30% from baseline versus non-responders.Responders with sustained response of at least 12 months or more were determined.ResultsA total of 2037 (F 1467 (72%) & M 570 (28%)) patients were treated.The overall responder rate was 1496 (73.4%) (F 1099 (74.9%) & M 397 (69.6%)).The Primary responder rate was similar for VHMW-HA (73.5% in Gr III OA & 77.0% in Gr IV OA) and HMW-HA (71.0% in Gr III OA & 68.6% in Gr IV OA).The Sustained response in VHMW-HA was greater (60.5% in Gr III OA & 68.5% in Gr IV OA) versus HMW-HA (47.3% in Gr III OA & 46.7% in Gr IV OA).Table 1.The results are summarized in Table -1: -INTERVENTION TYPEVHMW-HAVHMW-HAHMW-HAHMW-HATOTALRATEGRADE OF OAGrade III OAGrade IV OAGrade III OAGrade IV OAN%TOTAL PATIENTS TREATEDTotal (%)684 (33.6%)631 (31.0%)480 (23.6%)242 (11.9%)2037Females509418352188146772.0%Males1752131285457028.0%PRIMARY RESPONDERSTotal (%)503 (73.5%)486 (77.0%)341 (71.0%)166 (68.6%)149673.4%Females394330251124109974.9%Males109156904239769.6%SUSTAINED RESPONDERSTotal (%)414 (60.5%)432 (68.5%)227 (47.3%)113 (46.7%)118658.2%Females3112861668484777.1%Males103146612933985.4%NON RESPONDERSTotal (%)181 (26.5%)145 (23.0%)139 (29.0%)76 (31.4%)54126.6%Females115881016436825.1%Males6657381217330.4%Primary responders – Total WOMAC scores improvement of > 30% from baseline, Sustained responders - Sustained WOMAC improvement for >=12 mts., Non-responders - WOMAC change < 30% or Lost to follow up.OA-Osteoarthritis Knees, Grade III and IV OA - radiological KL Grade, VHMW-HA - Very high Molecular weight hyaluronic acid, HMW-HA -High molecular weight hyaluronic acid.ConclusionThe responders to treatment of 73.4% justify treatment outcome.The primary response to treatment was similar in all the subgroups – Type of IAHA, Grade of OA and Gender.However, the sustained response for 12 months or more was far greater in VHMW-HA versus HMW-HA.References[1]Mathers CD, Bernard C, Iburg KM, et al. Global programme on evidence for health policy. Discussion paper no. 54. 2003.http://www.who.int/healthinfo/paper54.pdf. Accessed 06 June 2019[2]Henrotin Y, Raman R, Richette P, et al. Consensus statement on Viscosupplementation with hyaluronic acid for the management of osteoarthritis. Semin Arthritis Rheum. 2015;45(2):140–149. [PubMed] [Google Scholar][3]du Souich P. Absorption, distribution and mechanism of action of SYSADOAS. Pharmacol Ther. 2014;142(3):362–374. [PubMed] [Google Scholar]Acknowledgements:NIL.Disclosure of InterestsAnish Kumar Aggarwal Speakers bureau: Novartis Healthcare, Pfizer Ltd., Johnson & Johnson, Cipla Ltd., Zydus Lifesciences Ltd., Emcure Pharma Ltd., Lupin Ltd, Intas Pharmaceuticals Ltd., Torrent Pharmaceuticals Ltd. and RPG lifesciences Ltd., JANE FITZPATRICK Consultant of: Bioventus Inc., NAKUL AGGARWAL: None declared.
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Iqbal, Ukasha, Nousheen Yousaf1, Alishba Chudhrey, Shumaila Rasheed, Muhammad Hanif e Samina Sarwar. "First Report of an edible mushroom, Termitomyces umkowaan from Punjab, Pakistan". Lahore Garrison University Journal of Life Sciences 8, n.º 2 (14 de junho de 2024): 172–84. http://dx.doi.org/10.54692/lgujls.2024.0802332.
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During the fungal forays for the collection of macro-fungi from different districts of Punjab province of Pakistan three specimens of Termitomyces were collected in the rainy seasons of the year 2021 and 2022s. After detailed morpho-anatomical studies, these specimens were recognized as T. umkowaan, which an edible taxon, and first time reported from two districts (Khanewal and Lahore) of Pakistan. In current study, taxonomic description, macrographs of basidiomata, illustrations and light micrographs of microscopic features are given. Morpho-anatomical comparison with similar species is also provided. REFERENCES Aryal HP, Budathoki U (2015). Systematics of Nepalese Termitomyces. Our Nature. 13: 31-44. http://dx.doi.org/10.3126/ on.v13i1.14207 Batra LR, Batra SWT (1979). Termite–fungus mutualism. Batra LR, Batra SWT editors. Insect-fungus symbiosis. New York, USA. https://lccn.loc.gov/78020640 Chakraborty I, Mondal S, Rout D, Islam SS (2006). A water-insoluble (1→ 3)-β-d-glucan from the alkaline extract of an edible mushroom Termitomyces eurhizus. Res. 341: 2990-2993. https://doi.org/10.1016/j.carres.2006.09.009 FrØSlev TG, Aanen DK, Laessøe T, Rosendahl S (2003). Phylogenetic relationships of Termitomyces and related taxa. Res. 107: 1277-1286. https://doi.org/10.1017/S0953756203008670 Heim R (1942). New descriptive studies on termitophilous agarics of tropical Africa. Nat. Hist. 6: 107-166. https://sciencepress.mnhn.fr/en/periodiques/archives-serie6/18/1/2 Hussain S, Afshan NS, Ahmad H, Khalid AN (2015). New report of edible mushroom, Termitomyces umkowaan from Pakistan. Sylwan. 159: 185-197. https://www.researchgate.net/publication/292158545_Title_New_Report_of_edible_mushroom_Termitomyces_umkowaan_from_Pakistan Izhar A, Khalid AN, Bashir H (2020). Termitomyces sheikhupurensis nov.(Lyophyllaceae, Agaricales) from Pakistan, evidence from morphology and DNA sequences data. Turk. J. Bot. 44: 694-704. https://journals.tubitak.gov.tr/cgi/viewcontent.cgi?article=1069&context=botany Kansci G, Mossebo DC, Selatsa AB, Fotso M (2003). Nutrient content of some mushroom species of the genus Termitomyces consumed in Cameroon. Food/Nahrung. 47: 213-216. https://pubmed.ncbi.nlm.nih.gov/12866626/ Karun NC, Sridhar KR (2013). Occurrence and distribution of Termitomyces (Basidiomycota, Agaricales) in the Western Ghats and on the west coast of India. Mykol. 65: 233-254. http://www.czechmycology.org/_cmo/CM65207.pdf Khowala S, Ghosh AK, Sengupta S (1992). Saccharification of xylan by an amyloglucosidase of Termitomyces clypeatus and synergism in the presence of xylanase. Microbiol. Biotechnol. 37: 287-292. https://link.springer.com/article/10.1007/BF00210979 Kirk PM, Cannon PF, Minter DW, Stalpers JA (2008). Dictionary of Fungi, 10th edn. CABI press, UK. https://www.researchgate.net/publication/311424562_Dictionary_of_the_Fungi10th_ed Nobre T, Aanen DK (2012). Fungiculture or Termite Husbandry? The Ruminant Hypothesi. Insects. 3: 307-323. Ogundana SK, Fagade OE (1982). Nutritive value of some Nigerian edible mushrooms. Food chem. 8: 263-268. https://doi.org/10.1016/0308-8146(82)90028-0 Razaq A, Ishaq A, Ilyas S, Niaz S, Sadia S (2023). Termitomyces pakistanensis, a new mushroom species from Pakistan based on scanning electron microscopy and ITS‐rDNA barcoding. Res. Tech. 86: 115-121. https://doi.org/10.1002/jemt.24265 Sultana K, Rauf CA, Riaz A, Naz F, Irshad G, Haque MI (2011). Checklist of agarics of Kaghan valley. Pak. J. Bot. 43: 1777-1787. Tang SM, He MQ, Raspe O, Luo X, Zhang XL, Li YJ, Su KM, Li SH, Thongklang N, Hyde KD (2020). Two new species of Termitomyces (Agaricales, Lyophyllaceae) from China and Thailand. Phytotaxa. 439: 231-242. 11646/PHYTOTAXA.439.3.5 Tibuhwa DD (2012). Termitomyces species from Tanzania, their cultural properties and unequalled basidiospores. J. Bio. Life Sci. 3: 2157-6076. http://dx.doi.org/10.5296/jbls.v3i1.1723 Usman M, Khalid AN (2020). Termitomyces acriumbonatus nov. (Lyophyllaceae, Agaricales) from Pakistan. Phytotaxa. 477: 217-228. Wei TZ, Tang BH, Yao YJ (2009). Revision of Termitomyces in China. Mycotaxon. 108: 257-285.
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Brown, K. C., e J. A. Weil. "Preparation of 2,2-diaryl-1-picrylhydrazyls using potassium permanganate". Canadian Journal of Chemistry 64, n.º 9 (1 de setembro de 1986): 1836–38. http://dx.doi.org/10.1139/v86-301.
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Potassium permanganate is used as a reagent for the oxidation of various 2,2-diaryl-1-picrylhydrazines to their corresponding hydrazyls. Thin-layer chromatography indicates complete oxidation of the hydrazine to free radical, unlike the case with PbO2 (the most widely used oxidant for this purpose). Several other advantages over previous oxidants used to produce the hydrazyls are offered.
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Bhaskar, A. Vijaya, Usharani G. e Sravani D. "Screening for Identification of Resistant Genotypes against Charcoal Rot Caused by Macrophomina phaseolina in Maize (Zea mays L.)". International Journal of Plant & Soil Science 35, n.º 23 (18 de dezembro de 2023): 222–37. http://dx.doi.org/10.9734/ijpss/2023/v35i234235.
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Screening of Maize entries for resistance to charcoal rot disease using 1-9 disease severity measuring scale in sick plot at field conditions. In this study,492entries with check were screened in randomized block design by tooth pick method of inoculation at Agricultural Research Station, Karimnagar, Telangana State, India during rabi and kharif. During rabi 2021-22, out of screened 212 lines,46 lines viz., KML-2, JCY-2-7, KML-4,KML-17,KML- 26,KML-33,KML-74,KML-76,KML-82,KNMH-4211,KNMH-4192,KNMH-131,KMH-396,KMH-393,KMH-770,KMH-286,KMH-275,KMH-318,S-6668,KMH-253,KMH-262,KMH-777,KMH-433,KMH-431,KMH-25,KMH-340,KMH-341,KMH-331,KMH-337,KMH-471,KMH-469,KMH-586,KMH-357,KMH-367,KMH-542,KMH-544,KMH543, KMH -131,KMH-394,KMH-400,KMH-545,KMH-194,DHM-121,BIO-9544,HT5106 and NK6802 were found moderately resistant, Kaveri-50 (Check) entry was recorded 8.10 disease scale and remaining lines were found susceptible to charcoal rot disease. Out of screened 280 lines,one line KMH-152 was found resistant ,77 lines were identified as moderately resistant,one line Kaveri -50 (check) was severely affected by Charcoal rot with 8.0disease rating and rated as susceptible during kharif, 2022.
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Zhang, Hui, Gang Yu, Yu Ming Wang e Chang Hu Xue. "Phospholipase D-Mediated Transphosphatidylation in Subcritical 1, 1, 1, 2-Tetrafluoroethane". Advanced Materials Research 343-344 (setembro de 2011): 743–47. http://dx.doi.org/10.4028/www.scientific.net/amr.343-344.743.
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Phospholipase D-mediated transphosphatidylation to phosphatidylserine from phosphatidylcholine was successfully performed using subcritical 1,1,1, 2-tetrafluoroethane (R134a) as reaction medium. Phospholipase D from Stretomyces sp was found to be active in subcritical R134a at 30-50°C and 2-8MPa; Higher velocity and conversion were observed with respect to those attained in conventional organic solvents. A maximum conversion of 84.88% was attained at 6 MPa, 40°C, after 240 minutes with 9.6 units phospholipase D.
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Lartaud, I., L. Bray-des-Boscs, J. M. Chillon, J. Atkinson e C. Capdeville-Atkinson. "In vivo cerebrovascular reactivity in Wistar and Fischer 344 rat strains during aging". American Journal of Physiology-Heart and Circulatory Physiology 264, n.º 3 (1 de março de 1993): H851—H858. http://dx.doi.org/10.1152/ajpheart.1993.264.3.h851.
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Basal cerebral blood flow (CBF) and CBF regulation after hypercapnia and hypotensive hemorrhage were investigated using H2 clearance in the frontal cortex of awake 2-, 14-, or 23-mo-old Wistar or Fischer 344 rats. Basal CBF decreased in old Wistar but not in mature Wistar (old 64.4 +/- 2.8, mature 87.6 +/- 2.6, young 79.6 +/- 2.2 ml.min-1 x 100 g-1) or in old Fischer 344 (old 71.9 +/- 2.9, young 73.3 +/- 1.6 ml.min-1 x 100 g-1) rats. Cerebrovascular reactivity to hypercapnia decreased in mature and old Wistar (old 2.1 +/- 0.3, mature 3.1 +/- 0.7, young 7.0 +/- 2.1 ml.min-1 x 100 g-1 x mmHg-1) but not in old Fischer 344 rats (old 4.6 +/- 1.4, young 4.9 +/- 0.9 ml.min-1 x 100 g-1 x mmHg-1). The lower limit of CBF autoregulation increased by 20 mmHg during maturation and/or aging in the two strains. Because blood gases and pH evolved similarly in both strains, we postulate that differences in cerebrovascular structure and/or function explain the differences in CBF regulation in the older representatives of the two strains.
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Fikadu, Tsehay, e Birhanu Mekassa. "Determination of heavy metals in cement dust, top soil and teff around Habesha and Mugher cement factory, Oromia Regional State, Ethiopia". Bulletin of the Chemical Society of Ethiopia 36, n.º 3 (15 de julho de 2022): 487–501. http://dx.doi.org/10.4314/bcse.v36i3.1.
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ABSTRACT. In this study, the level of selected heavy metals in cement dust, soil and teff samples collected from around Mugher and Habesha cement factories, Ethiopia were determined using flame atomic absorption spectroscopy (FAAS). The collected samples were digested using properly optimized acid digestion using a mixture of 5 mL HNO3:1 mL H2SO4:1 mL HClO4 at 200 oC for 2 h for the cement dust; 3 mL HNO3:4 mL HClO4:1 mL H2O2 at 300 °C for 3 h for the soil and 5 mL HNO3:3 mL H2O2 for 1:30 h at 200 °C for the teff samples. The mean concentrations of metals determined (mg/kg) were in the ranges of Cu (450.26-471.79), Zn (1096.75-1103.10), Mn (3316-3419), Cr (242-404), Fe (31846-33836), Ni (1524-1727), Co (2492-2517), Cd (20.4-26.1), Pb (255-649) for cement dust; Cu (294-333), Zn (194-330), Mn (498-521), Cr (330-450), Fe (5283-5392), Ni (1138-3719) and Co (1439-1516) for soil, Cu (85.6-89.4), Zn (314-466), Mn (733-741), Cr (297-342), Fe (1327-1574) for teff. Cd and Pb were not detected in the teff and soil samples. The soil and teff samples collected from the two cement factories contained significant level of heavy metals. Except iron, the level of heavy metals in soil and teff samples were above the permissible limit of FAO/WHO.
KEY WORDS: Cement factory, Cement dust, Soil, Teff, Wet digestion, Heavy metals
Bull. Chem. Soc. Ethiop. 2022, 36(3), 487-501.
DOI: https://dx.doi.org/10.4314/bcse.v36i3.1
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Tomkins, Oliver, Joshua Bomsztyk, Helen McCarthy, Jaimal Kothari, Dima El-Sharkawi, Charalampia Kyriakou, Guy Pratt, Ali Rismani e Shirley D'Sa. "An Analysis from the WM UK Rory Morrison Registry: Waldenström's Macroglobulinaemia Patient Demographics, Disease Characteristics and Evolving Treatment Choices". Blood 134, Supplement_1 (13 de novembro de 2019): 4016. http://dx.doi.org/10.1182/blood-2019-129212.
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Background Waldenström's macroglobulinaemia (WM) is a rare non-Hodgkin B cell lymphoma. Given its rarity, information about both patient demographics and disease characteristics are limited. Treatment is indicated for symptomatic patients and treatment regimens have evolved significantly in recent years. The Rory Morrison Registry (RMR) has comprehensive patient data available for analysis. We seek to draw conclusions about UK patient demographics and disease characteristics, and evaluate how treatment practices have evolved. Methods The RMR was searched for all patients with a diagnosis of WM. Patient demographics, disease characteristic, pathology results, treatment information and survival status retrieved. Kaplan Meier and log rank analysis was performed. Results 671 patients were identified from 19 different UK centres. Median age at diagnosis was 64 years (range 27-92, figure 1). Year of diagnosis ranged from 1978 to 2019, with 7 patients diagnosed <1990, 31 1990-1999, 200 2000-2009, and 433 since 2010. Male to female ratio was 1.62:1. 90.4% were Caucasian, 5.9% Asian, 1.3% Afro-Caribbean, 0.7% mixed, and 1.6% of other ethnicity. Median haemoglobin at diagnosis was 112g/L (range 33-170), platelet count 242 (3-806), B2M 3 (range 0.2-56.3) and M-protein 17g/L (range 0-110.5). Median bone marrow infiltration was 40% (range 0-100%), with 35% lymphocytes and 5% plasma cell. MYD88 L265P mutations were detected in 160/190 patients (84.2%). CXCR4 mutations, for which testing is not widely available, were detected in 20/76 patients (26.3%). Peripheral neuropathy was seen in 74 patients, with 28 anti-MAG antibody positive. Other manifestations at diagnosis included cryoglobulinaemia (26), amyloidosis (12) and Schnitzler's syndrome (7). 2/317 patients were HIV positive, 4/341 HCV antibody positive, 27/334 HBSAb positive, and 12/327 HBCAb positive. IPSSWM score at diagnosis was available for 352 patients, with a low score in 122 (34.7%), intermediate score in 103 (29.3%), and high score in 123 (45%). 440 patients (65.6%) had received treatment, with a median time from diagnosis to treatment of two months (range 0-312). Indications for first line treatment initiation were: 35% paraprotein-related, 30% lymphoma-related , 2.1% B-symptoms, and a combination of indications for the remainder. Hyperviscosity was the treatment indication in 24.8% of patients, fatigue in 21.6% and peripheral neuropathy in 9.8%. At treatment commencement, 47% of patients had a haemoglobin of <100g/L. CNS involvement was a feature in 1.5% and 1.5% high grade transformation (HGT). Lines of therapy received was one in 43.6%, two in 24.1%, three in 4.8%, four in 6.6% and ≥5 in 10.9%. In the past decade, 27.8% received DRC, 16.4% R-Bendamustine, 8.9% rituximab monotherapy, 7.7% R-CHOP and the rest varying combinations. 2.2% had received Bortezomib-containing therapy. Before 2010, chlorambucil (21.8%), R-CHOP (10.9%) and FC (9.3%) were the most frequently used first line treatments. BTK-inhibitors have become the most commonly used second line therapy, representing 23% of second line therapy after 2010, reflecting the availability of Ibrutinib on the Cancer Drugs Fund from 2017 and the availability of BTKi trials since 2015. 88 patients had received a BTKi at some point. 118 patients had deceased. Only 30 patients had a cause of death available; this included 7 patients who died from WM itself, 6 from pneumonia, 5 from sepsis (2 were neutropaenic), 3 from HGT, 2 from haemorrhage, 2 from thrombotic events, and 1 from CNS relapse. 5- and 10-year OS rates from diagnosis were 90.5% and 79.4%, with a significant difference in OS rates according to IPSSWM risk at diagnosis (p<0.001, figure 2). There was a trend towards difference in OS rates (P=0.095) according to MYD88 status, with somewhat poorer OS rate amongst MYD88 wild-type patients. CXCR4-status did not impact the OS rate (p=0.93). Conclusions The median age at diagnosis was 64 years, with a third of patients diagnosed under the age of 60. Although diverse, the most frequent indications for treatment in this cohort are hyperviscosity, fatigue and peripheral neuropathy. OS rates are high and correlate with IPSSWM risk, but a majority of patients had received multiple lines of therapy reflecting the chronically relapsing nature of WM. Treatment practices are clearly evolving, with increasing first line use of DRC and R-Bendamustine, as well as BTK inhibitors for relapsed disease. Disclosures McCarthy: Janssen: Honoraria, Other: Educational grant to attend meetings . Pratt:Binding Site, Amgen, Takeda, Janssen, Gilead: Consultancy, Honoraria, Other: Travel support. D'Sa:Janssen: Honoraria, Research Funding.
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Jawed, Yameena, Eleni Beli, Keith March, Anthony Kaleth e M. Terry Loghmani. "Whole-Body Vibration Training Increases Stem/Progenitor Cell Circulation Levels and May Attenuate Inflammation". Military Medicine 185, Supplement_1 (janeiro de 2020): 404–12. http://dx.doi.org/10.1093/milmed/usz247.
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Abstract Introduction Whole-body vibration training (WBVT) may benefit individuals with difficulty participating in physical exercise. The objective was to explore the effects of WBVT on circulating stem/progenitor cell (CPC) and cytokine levels. Methods Healthy male subjects each performed three activities randomly on separate days: (1) standing platform vibration, (2) repetitive leg squat exercise; and (3) in combination. Pre- and post-activity blood samples were drawn. Cell populations were characterized using flow cytometry. Biomarkers were analyzed using enzyme-linked immunosorbent assays. Results CPC levels increased significantly 21% with exercise alone (1465 ± 202–1770 ± 221 cells/mL; P = 0.017) and 33% with vibration alone in younger participants (1918 ± 341–2559 ± 496; P = 0.02). Angiogenic CPCs increased 39% during combined activity in younger (633 ± 128–882 ± 181; P = 0.05). Non-angiogenic CPCs increased 42% with vibration alone in younger (1181 ± 222–1677 ± 342; P = 0.04), but 32% with exercise alone in older participants (801 ± 251–1053 ± 325; P = 0.05). With vibration alone, anti-inflammatory cytokine interleukin-10 increased significantly (P < 0.03), although inflammatory interleukin-6 decreased (P = 0.056); tumor necrosis factor-alpha (P < 0.01) and vascular endothelial growth factor levels increased (P < 0.005), which are synergistically pro-angiogenic. Conclusions WBVT may have positive vascular and anti-inflammatory effects. WBVT could augment or serve as an exercise surrogate in warfighters and others who cannot fully participate in exercise programs, having important implications in military health.
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Czerwensky, Fabian, Stefan Leucht e Werner Steimer. "MC4R rs489693: a clinical risk factor for second generation antipsychotic-related weight gain?" International Journal of Neuropsychopharmacology 16, n.º 9 (1 de outubro de 2013): 2103–9. http://dx.doi.org/10.1017/s1461145713000849.
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Abstract Weight gain is a therapy limiting and very frequent adverse effect of many second-generation antipsychotic (SGA) drugs. The human melanocortin four receptor (MC4R) is a very promising candidate gene possibly influencing SGA-related weight gain. The rs489693 polymorphism near the MC4R gene was associated with SGA-related weight gain in a genome-wide association study. We tried to replicate these results in our independent naturalistic study population. From 341 Caucasian inpatients receiving at least one SGA drug (olanzapine, clozapine, risperidone, paliperidone, quetiapine or amisulpride), carriers homozygous for the rs489693 A-allele (n = 35) showed a 2.2 times higher weight increase (+2.2 kg) than carriers of the CC-genotype (+1 kg) after 4 wk of treatment (analysis of covariance, p = 0.039). We revealed an even stronger effect in a subpopulation without weight gain inducing co-medication (factor 3.1, +2.8 kg, p = 0.044, (n = 16 of 169)) and in first episode patients (factor 2.7, +2.7 kg, p = 0.017, (n = 13 of 86)). Our results confirm the rs489693 A-allele as a possible risk factor for SGA-related weight gain.
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De Mul, Aurélie, Alice Heneau, Valérie Biran, Alexandra Wilhelm-Bals, Paloma Parvex, Antoine Poncet, Marie Saint-Faust e Olivier Baud. "Early urine output monitoring in very preterm infants to predict in-hospital neonatal outcomes: a bicentric retrospective cohort study". BMJ Open 13, n.º 1 (janeiro de 2023): e068300. http://dx.doi.org/10.1136/bmjopen-2022-068300.
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ObjectiveTo evaluate whether urine output (UO), rarely assessed in the literature, is associated with relevant neonatal outcomes in very preterm infants, and which UO threshold may be the most clinically relevant.DesignRetrospective cohort study.SettingTwo Level IV neonatal intensive care units.PatientsVery preterm infants born between 240/7and 296/7weeks of gestation documented with eight UO measurements per day between postnatal day 1 and day 7.Main outcome measuresComposite outcome defined as death before discharge, or moderate to severe bronchopulmonary dysplasia, or severe brain lesions. The association between this outcome and UO was studied using several UO thresholds.ResultsAmong 532 infants studied, UO <1.0 mL/kg/hour for at least 24 consecutive hours was measured in 55/532 (10%) infants and the primary outcome was recorded in 25 patients. The association between a UO threshold <1.0 mL/kg/hour and the primary outcome was found marginally significant (crude OR 1.80, 95% CI 1.02 to 3.16, p=0.04). The primary outcome was recorded in 112/242 (46%) patients with a UO <2.0 mL/kg/hour and only 64/290 (22%) patients with a UO ≥2.0 mL/kg/hour (p<0.001). This UO threshold was found significantly associated with the primary outcome (crude OR 3.1, 95% CI 2.1 to 4.7, p<0.001), an association confirmed using a multivariate logistic regression model including baseline covariates (adjusted OR 3.7, 95% CI 2.2 to 6.4, p<0.001).ConclusionA UO <2 mL/kg/hour over 24 hours between postnatal day 1 and day 7 strongly predicts neonatal mortality or severe morbidities in very preterm infants.
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Dutton, Tegan, Wendy Stevens e Jamie Newman. "Health assessments for Indigenous Australians at Orange Aboriginal Medical Service: health problems identified and subsequent follow up". Australian Journal of Primary Health 22, n.º 3 (2016): 233. http://dx.doi.org/10.1071/py14120.
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This study aimed to document the types, management and follow up of health issues identified by all Aboriginal Health Assessments (AHA) performed at Orange Aboriginal Medical Service from 1 January 2011 to 31 December 2012. This was done with a retrospective audit of clinical records. In total, 1169 AHAs were performed: 41% child, 53% adult and 6% older person AHAs. Newly identified health issues were documented in 85% (984). Being overweight (41%; 476) and smoking (26%; 301) were the common risk factors identified. As a result of the AHA, most children who were not up-to-date with their vaccinations received catch-up immunisations; 11% (36) of adult women (n=314) received a Pap smear, although Pap smear status was unknown or not up-to-date for 61% (192); 27% (311) of cases were prescribed new medication; and 1239 referrals were made but only 40% were attended. At 6 months following the AHA, 26% (240) of cases with newly identified health issues were completely managed and followed up, whereas 25% (226) received no follow up. The AHAs are useful for identifying new health issues; however, follow up of the identified health issues should be improved. If AHAs are to improve health outcomes, appropriate management and follow up of the identified health issues are essential.
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Davis, GP, NJ Corbet, MJ Mackinnon, DJS Hetzel, KW Entwistle e R. Dixon. "Response in female fertility and calf growth to selection for pregnancy rate in tropical beef cattle". Australian Journal of Agricultural Research 44, n.º 7 (1993): 1509. http://dx.doi.org/10.1071/ar9931509.
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Direct response to divergent selection based on estimated breeding value for female pregnancy rate in a herd of Bos indicus cross cattle was evaluated along with correlated responses in calf survival, weaning rate, cow liveweight and calf growth. Pregnancy rates were significantly higher ( P < 0.05) in heifers of the High line compared with the Low line (High-Low=15� 5%) and in lactating 4-year-old cows (25�9.5%) and in 3 of the 5 years of the study (average difference 24%). The Low line had significantly ( P < 0.05) higher pregnancy rates in 1 year (-16�5.4%). These differences in pregnancy rates were reflected in weaning rates, but calf survival was only different between the lines in 2 of the 4 years analysed (-6� 3.0% in 1990 and 18�6.5% in 1991). The High line had a significantly ( P < 0.05) shorter days to calving than the Low line in heifers (High=309�2.2 days v. Low= 315�2.5 days), lactating 3-year-old cows (3l5� 3.6 days v. 331�4.1 days), non-lactating 3-year-old cows (301�5.4 days v. 320�4.6 days) and lactating 4-year-old cows (311�3.9 days v. 336�4.9 days). Differences between the lines in pre-weaning growth varied according to generation with significantly lower (P < 0.05) weaning weights (182�3.1 kg v. 189�3.3 kg) and pre-weaning growth (790�17 g/day v. 826� 17 g/day) in first generation High line calves from foundation dams and no difference between the lines in second generation calves from first generation dams. Post-weaning growth was significantly higher ( P < 0.05) in High line calves (350� 5 g/day v. 327�5 g/day). The results indicate that selection of sires on EBV for pregnancy rate leads to improved fertility in heifers and 4-year-old lactating cows without adverse effects on progeny growth.
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Malone, Vincent F., Amy J. Chastain, John T. Ohlsson, Loelle S. Poneleit, Michele Nemecek-Marshall e Ray Fall. "Characterization of a Pseudomonas putidaAllylic Alcohol Dehydrogenase Induced by Growth on 2-Methyl-3-Buten-2-ol". Applied and Environmental Microbiology 65, n.º 6 (1 de junho de 1999): 2622–30. http://dx.doi.org/10.1128/aem.65.6.2622-2630.1999.
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ABSTRACT We have been working to develop an enzymatic assay for the alcohol 2-methyl-3-buten-2-ol (232-MB), which is produced and emitted by certain pines. To this end we have isolated the soil bacteriumPseudomonas putida MB-1, which uses 232-MB as a sole carbon source. Strain MB-1 contains inducible 3-methyl-2-buten-1-ol (321-MB) and 3-methyl-2-buten-1-al dehydrogenases, suggesting that 232-MB is metabolized by isomerization to 321-MB followed by oxidation. 321-MB dehydrogenase was purified to near-homogeneity and found to be a tetramer (151 kDa) with a subunit mass of 37,700 Da. It catalyzes NAD+-dependent, reversible oxidation of 321-MB to 3-methyl-2-buten-1-al. The optimum pH for the oxidation reaction was 10.0, while that for the reduction reaction was 5.4. 321-MB dehydrogenase oxidized a wide variety of aliphatic and aromatic alcohols but exhibited the highest catalytic specificity with allylic or benzylic substrates, including 321-MB, 3-chloro-2-buten-1-ol, and 3-aminobenzyl alcohol. The N-terminal sequence of the enzyme contained a region of 64% identity with the TOL plasmid-encoded benzyl alcohol dehydrogenase of P. putida. The latter enzyme and the chromosomally encoded benzyl alcohol dehydrogenase ofAcinetobacter calcoaceticus were also found to catalyze 321-MB oxidation. These findings suggest that 321-MB dehydrogenase and other bacterial benzyl alcohol dehydrogenases are broad-specificity allylic and benzylic alcohol dehydrogenases that, in conjunction with a 232-MB isomerase, might be useful in an enzyme-linked assay for 232-MB.
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Glaspy, John, Tom Tang, Dean Rutty, Xiaoqiang Yan, Igor Bondarenko e Dmitrii Krasnozhon. "A Phase II, Randomized, Multi-Centre, Open-Label, Active-Controlled, Dose-Finding Trial of F-627 (benefilgrastim) in Women with Breast Cancer Receiving Myelotoxic Chemotherapy". Blood 124, n.º 21 (6 de dezembro de 2014): 1584. http://dx.doi.org/10.1182/blood.v124.21.1584.1584.
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Abstract Neutropenia is common in patients receiving myelotoxic chemotherapy. Benefilgrastim, an rhG-CSF dimer (rhG-CSF-FC fusion protein), is a once-per-cycle therapy for prophylactic neutrophil support. In this Phase II trial, 230 women with stage I-IV breast cancer are to be treated for 4 chemotherapy cycles with either docetaxel/cyclophosphamide (TC) or doxorubicin/docetaxel/cyclophosphamide (TAC) chemotherapy, with each cycle lasting approximately 21 days. Patients will be randomized to receive either benefilgrastim or pegfilgrastim (Neulasta; 6 mg fixed dose) one day after chemotherapy during each cycle, as a subcutaneous injection. Dose levels of benefilgrastim examined are 80 µg/kg (TC patients only), and 240 and 320 µg/kg (TC and TAC patients). The primary endpoint is the duration of grade 3/4 neutropenia in chemotherapy cycle 1. As of August 1, 2014, 232 patients have completed chemotherapy cycle 1; safety and efficacy were analyzed for these enrolled patients. For the TC chemotherapy regimen, a total of 141 patients were randomized (ratio = 1:1:1:1) into 4 arms (80, 240, and 320 µg/kg benefilgrastim or 6 mg pegfilgrastim). In the TAC chemotherapy regimen, a total of 91 patients were randomized (ratio = 1:1:1) into 3 arms (240 and 320 µg/kg benefilgrastim or 6 mg pegfilgrastim). The incidence of grade 3/4 and grade 4 neutropenia and their mean durations in cycle 1 are provided in Table 1. There were higher incidences of grade 3/4 and grade 4 neutropenia in the TAC regimen compared to the TC regimen. The safety profiles of benefilgrastim and pegfilgrastim were similar. A total of 10 SAEs were reported in 6 patients with the majority (7 SAEs in 4 patients) occurring in those receiving pegfilgrastim. The most commonly observed treatment emergent adverse events (>10% of total TC + TAC patients) were: alopecia, nausea, asthenia, neutropenia, bone pain, and fatigue. The rates were similar amongst treatment regimens and treatment groups. In summary, a single subcutaneous injection of benefilgrastim 240 or 320 µg/kg provided neutrophil support to patients treated with both the TC and TAC chemotherapy regimens. The safety profile of benefilgrastim was comparable to that of pegfilgrastim during multiple chemotherapy cycles. The results suggest a potential use of benefilgrastim for the management of severe neutropenia in cancer patients undergoing high dose chemotherapy. Abstract 1584. Table 1: Preliminary Results TC Regimen TAC Regimen Benefilgrastim Pegfilgrastim 6 mg (N=35) Benefilgrastim Pegfilgrastim 6 mg (N=29) 80 µg/kg (N=35) 240 µg/kg (N=37) 320 µg/kg (N=34) 240 µg/kg (N=29) 320 µg/kg (N=30) Grade 3/4 neutropenia n/N (%) 10/35 (28.6) 10/37 (27.0) 7/34 (20.6) 7/35 (20.0) 17/25 (68.0) 19/26 (73.1) 17/24 (70.8) Duration (days) Mean (SD) 95% CI 2.4 (2.07) 1.2, 3.6 2.2 (0.79) 1.7, 2.7 1.9 (0.38) 1.6, 2.1 1.4 (0.79) 0.9, 2.0 2.8 (1.67) 2.1, 3.5 2.6 (1.07) 2.2, 3.1 2.2 (0.73) 1.9, 2.5 Grade 4 neutropenia n/N (%) 4/35 (11.4) 7/37 (18.9) 6/34 (17.6) 3/35 (8.6) 14/25 (56.0) 17/26 (65.4) 15/24 (62.5) Duration (days) Mean (SD) 95% CI 2.0 (1.15) 0.6, 3.4 2.1 (0.90) 1.5, 2.8 1.2 (0.41) 0.8, 1.5 1.0 (0.00) 1.0, 1.0 1.9 (1.33) 1.3, 2.6 2.0 (0.87) 1.6, 2.4 1.5 (0.64) 1.2, 1.8 SAEs n (%) # SAEs 0 0 1 (2.7) 1 0 0 2 (5.7) 3 0 0 1 (3.3) 2 2 (6.9) 4 CI=confidence interval; SAE=serious adverse event; SD=standard deviation Disclosures Glaspy: Generon (Shanghai) Corporation Ltd.: Research Funding. Tang:Generon (Shanghai) Corporation Ltd.: Employment. Rutty:Everest Clinical Research Services Inc.: Employment; Generon (Shanghai) Corporation Ltd.: Consultancy; Schering Corporation: Consultancy; Roche: Consultancy; Methylgene: Consultancy; Steba Biotech SA: Consultancy; Aderans Research Institute Inc: Consultancy; Stem Cell Theraputics: Consultancy; Genentech: Consultancy; Pearly Therapeutics: Consultancy; Sundise Chinese Medicine Technology Development Corp: Consultancy; Endocyte, Inc: Consultancy; Hutchison Medipharma: Consultancy; Nutrition Science Partners Limited: Consultancy. Yan:Generon (Shanghai) Corporation Ltd.: Employment.
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Patel, Priti, Mayra Telesca e De-Hui Ku. "The Comparison of Fibrin Monomer (FM) Performance to Other Activation Markers (TAT, PF1.2 and DD)". Blood 118, n.º 21 (18 de novembro de 2011): 5259. http://dx.doi.org/10.1182/blood.v118.21.5259.5259.
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Abstract Abstract 5259 In this study, we attempted to determine the performance of the soluble fibrin monomer complex (SFMC) test in comparison to known activation markers, such as prothrombin fragment 1.2 (PF1.2), thrombin antithrombin complex (TAT) and d-dimer (DD). We have used the STA(R)-Liatest FM and STA(R)-Liatest D-Di kits to measure the SFMC and d-dimer levels. A total of 25 patients were included in this study. The data and demographic information are shown in the table below. ID GENDER AGE FM TAT PF1.2 D-dimer 1 M 66 0.42 2.3 1988 0.05 2 F 31 27.93 >60.0 >12000 2.39 3 F 24 3.41 14.1 1367 0.48 4 F 61 2.22 7.7 335 0.63 5 F 18 4.61 6.9 940 0.22 6 F 38 156.52 43.5 >12000 10.37 7 F 20 0.42 2.2 149 0.66 8 F 21 0.42 2.4 143 0.24 9 M 44 >150 15.4 11043 5.5 10 F 42 3.4 <2.0 134 0.24 11 M 46 0 4.8 271 0.3 12 M 76 90.73 29.4 1712 >20.0 13 F 61 3.41 3.8 484 0.52 14 M 1 0.1 3.8 116 0.33 15 F 33 4.2 37 6346 2.03 16 F 35 3.2 2.6 325 0.09 17 F 23 1.1 4.7 232 0.2 18 M 64 2.3 2.6 189 0.15 19 M 1 1.7 2.9 253 0.49 20 M 64 2.2 33.2 451 2.43 21 M 60 1.6 2.9 126 0.42 22 F 55 2.2 2.6 189 0.97 23 F 65 1.3 2.3 79 0.25 24 F 39 3.6 8.1 222 0.18 25 M 2 4.8 <2.0 109 0.53 Reference range >6.0 ug/mL <4 mcg/L 41–372 pmol/L <0.45 ug/mL The data indicate that in 16 out 25 patients, the SFMC levels are correlated with TAT and PF1.2. Only 3 out of 25 patients have elevated TAT and PF1.2 with normal SFMC levels. Therefore, our data would tend to indicate that SFMC level could be used as an activation marker to assess an ongoing prothrombotic process. In order to more fully determine the efficacy of the SFMC assay, we will obtain a detailed clinical history for the cases shown above. Disclosures: No relevant conflicts of interest to declare.
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Yee, Timothy Joseph, Cheerag D. Upadhyaya, Domagoj Coric, Eric A. Potts, Erica Fay Bisson, Jay D. Turner, Jack Knightly et al. "288 Impact of Disc Degeneration on Clinical Outcomes After Fusion for Grade 1 Spondylolisthesis: A 5-year QOD Study". Neurosurgery 70, Supplement_1 (abril de 2024): 82. http://dx.doi.org/10.1227/neu.0000000000002809_288.
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INTRODUCTION: Disc degeneration with loss of disc height can be an indication to fuse patients with lumbar spondylosis. However, its relevance for spondylolisthesis is unknown. METHODS: The Quality Outcomes Database was queried for adult patients who underwent fusion for single-level degenerative grade 1 lumbar spondylolisthesis. Pfirrmann grade at the level to be fused was assessed on preoperative sagittal T2-weighted MRI. VAS-back pain (BP-VAS), VAS-leg pain (LP-VAS), and ODI were collected preoperatively and at 3, 12, 24, 36, and 60 months postoperatively. RESULTS: The query returned 395 patients. Mean age (95% CI) was 60 (58.9-61.1) years; 39.5% were male. None had a Pfirrmann grade 1 disc. One (0.3%) had a grade 2 disc, 53 (13.4%) had a grade 3 disc, 245 (62%) had a grade 4 disc, and 96 (24.3%) had a grade 5 disc. Posterior-only approach was performed in 92.6%; interbody graft was placed in 92.7%. Mean BP-VAS (95% CI) at baseline, 3 months, 12 months, 24 months, 36 months, and 60 months were 7.1 (6.8-7.3) (n = 343), 3.1 (2.8-3.3) (n = 353), 2.9 (2.6-3.2) (n = 305), 3.2 (2.8-3.5) (n = 283), 3.5 (2.9-4.1) (n = 107), and 3.7 (3.3-4.0) (n = 324). Mean LP-VAS (95% CI) were 6.7 (6.4-7.0) (n = 392), 2.3 (2.0-2.6) (n = 353), 2.2 (1.9-2.6) (n = 306), 2.6 (2.2-2.9) (n = 284), 2.8 (2.2-3.4) (n = 107), and 2.8 (2.4-3.1) (n = 322). Mean ODI (95% CI) were 49.4 (47.8-51.1) (n = 392), 27.4 (25.3-29.5) (n = 347), 22.9 (20.6-25.2) (n = 313), 22.4 (20.1-24.8) (n = 291), 22.4 (18.3-26.4) (n = 97), and 25.9 (23.7-28.2) (n = 325). Utilizing linear regression, Pfirrmann grade was not associated with improvements in VAS-BP, VAS-LP, or ODI at any time point in unadjusted and adjusted analyses (p > 0.05). CONCLUSIONS: Patients who undergo fusion for single-level grade 1 spondylolisthesis are likely to experience significant and sustained improvements in pain and function regardless of severity of disc degeneration.
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Goyer, M., H. Bui, L. Chou, J. Evans, L. C. Keil e I. A. Reid. "Effect of inhibition of nitric oxide synthesis on vasopressin secretion in conscious rabbits". American Journal of Physiology-Heart and Circulatory Physiology 266, n.º 2 (1 de fevereiro de 1994): H822—H828. http://dx.doi.org/10.1152/ajpheart.1994.266.2.h822.
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NO synthase is present in magnocellular neurons of supraoptic and paraventricular nuclei as well as in the posterior pituitary gland and may participate in control of vasopressin secretion. To test this possibility, experiments were performed in conscious, chronically prepared rabbits to determine the effect of NO synthesis inhibition with NG-nitro-L-arginine methyl ester hydrochloride (L-NAME) on basal vasopressin secretion and vasopressin responses to increased plasma osmolality (hypertonic saline infusion; P osm) and decreased blood pressure (nitroprusside infusion). L-NAME infusion (0.5 mg.kg-1 x min-1 i.v.) increased mean arterial pressure [MAP; 82.6 +/- 3.4 to 93.0 +/- 3.0 mmHg (P < 0.02)], decreased heart rate [HR; 242 +/- 12 to 209 +/- 9 beats/min (P < 0.02)], decreased plasma renin activity [PRA; 3.1 +/- 0.6 to 2.0 +/- 0.6 ng.ml-.2 h-1 (P < 0.001)], and increased plasma vasopressin concentration [P AVP; 2.2 +/- 0.3 to 4.5 +/- 1.0 pg/ml (P < 0.05)]. P(osm) did not change. Hypertonic saline infusion did not change MAP or HR but decreased PRA [4.3 +/- 0.8 to 0.9 +/- 0.2 ng.ml-1 x 2 h-1 (P < 0.01)], increased P(osm) [284 +/- 1 to 305 +/- 2 mosmol/kg H2O (P < 0.001)], and increased PAVP [2.8 +/- 0.3 to 12.7 +/- 2.7 pg/ml (P < 0.01)].(ABSTRACT TRUNCATED AT 250 WORDS)
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Yazdani, H., H. Rahmani, M. Edris e E. Dirandeh. "158. EFFECT OF A59V LOCUS IN THE LEPTIN GENE ON LENGTH OF PREGNANCY IN IRANIAN HOLSTEIN COWS". Reproduction, Fertility and Development 21, n.º 9 (2009): 76. http://dx.doi.org/10.1071/srb09abs158.
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We investigated effect of A59V polymorphism in the leptin gene on length of pregnancy. Blood was collected from 255 Holstein cattles belonging to four different herd managements in Isfahan province. Genomic DNA extracted from whole blood. Genotypes of A59V locus were identified PCR-RFLP technique. Amplified region is located in exon three of leptin gene. The genomic bovine leptin sequences, which consist of three exons, were obtained from Gene Bank (Accession number U50365). The polymerase chain reaction was used to amplify the 331 bp DNA fragments from genomic DNA. The PCR reaction contained 100 ng of genomic DNA, 0.3 µM of each primer, 1.5 mM MgCl2, 200 µM dNTP, 10mM Tris HCl, 50 mM KCl and 1 U Taq-polymerase in total volume of 20 µL. Sequences of primers that were used in PCR were reported previously by Haegeman et al. (2000). Conditions for PCR were 94°C for 2 min, followed by 35 cycles of 94°C for 30 s, 55°C for 1 min, and 72°C for 30 s. Followed by final extension for at for 15 min 72°C. Digestion of PCR product of 331 bp with 5 U of HphI (Fermentas) in 20 µL of reaction volume at 37°c for 8 h and analyzed on 8% no denature polyacrylamyde gel. Allele A in the A59V locus was the allele not digested by restriction enzyme, allele B was the restriction enzyme-digested PCR product. Digestion revealed 3 genotypes, AA (331 bp), AB (331, 311, and 20 bp), and BB (311 and 20 bp). Significances of the genotype effects were estimated by GLM procedure of SAS. This study showed that genotype effect on length of pregnancy were significant (P<0.01). Animals homozygous for allele A had higher length of pregnancy ((P<0.01, AA=279.17±0.47, AB=276.96±0.57, BB=274.8±2.2).
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Mzengereza, Kumbukani, Manabu Ishikawa, Shunsuke Koshio, Saichiro Yokoyama, Zhang Yukun, Ronick S. Shadrack, Seok Seo et al. "Effect of Substituting Fish Oil with Camelina Oil on Growth Performance, Fatty Acid Profile, Digestibility, Liver Histology, and Antioxidative Status of Red Seabream (Pagrus major)". Animals 11, n.º 7 (2 de julho de 2021): 1990. http://dx.doi.org/10.3390/ani11071990.
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A 56-day feeding trial to evaluate the responses of red seabream (initial weight: 1.8 ± 0.02 g) to the substitution of fish oil (FO) with camelina oil (CO) at different ratios was conducted. The control diet formulated at 46% CP (6F0C) contained only FO without CO; from the second to the fifth diet, the FO was substituted with CO at rates of 5:1 (5F1C), 4:2 (4F2C), 3:3 (3F3C), 2:4 (2F4C), and 0:6 (0F6C). The results of the present study showed that up to full substitution of FO with CO showed no significant effect on growth variables BW = 26.2 g–28.3 g), body weight gain (BWG = 1275.5–1365.3%), specific growth rate (SGR = 4.6–4.7), feed intake (FI = 25.6–27.8), feed conversion ratio (FCR = 1.0–1.1), biometric indices condition factor (CF = 2.2–2.4), hepatosomatic index (HSI = 0.9–1.1), viscerasomatic index (VSI = 7.5–9.5), and survival rates (SR = 82.2–100) with different FO substitution levels with CO. Similarly, there were no significant differences (p < 0.05) found in the whole-body composition except for the crude lipid content, and the highest value was observed in the control group (291 g/kg) compared to the other groups FO5CO1 (232 k/kg), FO4CO2 (212 g/kg), FO2CO4 (232 g/kg) and FO0CO6 (244 g/kg). Blood chemistry levels were not influenced in response to test diets: hematocrit (36–33%), glucose (Glu = 78.3–71.3 mg/dL), total protein (T-pro = 3.1–3.8 g/dL), total cholesterol (T-Chol = 196.0–241 mg/dL), blood urea nitrogen (BUN = 9.0–14.6 mg/dL), total bilirubin (T-Bil = 0.4–0.5 mg/dL), triglyceride (TG = 393.3–497.6 mg/dL), alanine aminotransferase test (ALT = 50–65.5 UL/L), aspartate aminotransferase test (AST = 38–69.3 UL/L). A remarkable modulation was observed in catalase (CAT) and superoxide dismutase (SOD) activities in the liver, as CAT and SOD values were lower with the complete FO substitution with CO (0F6C), and the highest values were observed in the control and (4F2C). This study indicates that red seabream may have the ability to maintain LC-PUFAs between tissues and diets, and CO substitution of FO could improve both lipid metabolism and oxidation resistance as well as maintain digestibility. In conclusion, dietary FO can be replaced up to 100% or 95% by CO in the diets of red seabream as long as n-3 HUFA, EPA, and DHA are incorporated at the recommended level.
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Rößer, Hans-Otto. "Jugendwerk der Deutschen Shell (Hrsg.): Jugend ’92. Band 1: Gesamtdarstellung und biografische Porträts. Opladen: Leske + Budrich, 1992. Jugend ’92. Band 2: Im Spiegel der Wissenschaften. Opladen: Leske + Budrich, 1992". Informationen Deutsch als Fremdsprache 21, n.º 2-3 (1 de abril de 1994): 243–46. http://dx.doi.org/10.1515/infodaf-1994-212-341.
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Radivoyevitch, Tomas, Rainer K. Sachs, Robert Peter Gale, Mikkael A. Sekeres, Jaroslaw P. Maciejewski, Matt Kalaycio e Sudipto Mukherjee. "Estimating Therapy-Related Myeloid Neoplasm Risks in the US". Blood 124, n.º 21 (6 de dezembro de 2014): 2617. http://dx.doi.org/10.1182/blood.v124.21.2617.2617.
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Abstract Background: Therapy-related myeloid neoplasms (t-MN) have traditionally been a dreaded but rare complication arising from the treatment of other cancers. With rising numbers of long-term cancer survivors, there is growing concern for increasing rates of t-MN. We provide estimates of the relative risks of developing these secondary cancers after various 1st cancers. Methods: We used the Surveillance Epidemiology and End Results (SEER) data 1973-2011 and the R package SEERaBomb to examine 33 primary cancer risks of subsequent MN defined as acute myeloid leukemia (AML), chronic myeloid leukemia (CML), chronic myelomonocytic leukemia (CMML), or myelodysplastic syndromes (MDS). First time cancer survivor person-years at risk (PY) for developing a second cancer were computed based on age-at-diagnosis of the first cancer, survival time, and age at diagnosis of any second cancer. Individual PY age intervals were stacked using R objects of class GRanges and the function coverage() of the Bioconductor package GenomicRanges. This yielded PY that we multiplied into age specific incidence rates computed using all t-MN regardless of being 1st, 2nd or later cancers. This yielded cases expected under a null hypothesis of t-MN being independent of prior cancers. Relative risks (RR) were then computed as observed/expected (O/E) cases and ordered by lower limit ([O - 2sqrt(O)]/E) distances from 1. PY and t-MN were restricted to those arriving after 1/1/2006 to avoid MDS incidence transients that arose immediately after its introduction into SEER in 2001. Results: 2,361 white females (Table 1), 3,415 white males (Table 2), 239 African American (AA) females (Table 3), and 309 AA males (Table 4), had t-MN diagnosed after 1/1/2006 that were known to have occurred at least 1 year after the 1st cancer. In these tables/results: RR after non-Hodgkin lymphoma (NHL), Hodgkin's disease (HD), and multiple myeloma (MM) was high, save MM in AA males; high risks after acute lymphocytic leukemia (ALL) and brain cancer were not significant for 1st cancers diagnosed >15 years of age, so these are due to childhood 1st cancers; and high risks of 2nd MN after a 1st are largely due to progressions being classified as 2nd cancers. Conclusion: t-MN with histories of NHL, HD, and MM may be enriched for truly treatment-induced cases. Mechanistic studies of t-MN should focus on such patients. Table 1. t-MN in White Females 1st Cancer O E RR ALL 16 0.6 27.4 (13.7, 41.1)* MN 99 13.3 7.5 (6, 9) NHL 235 60 3.9 (3.4, 4.4) Hodgkin's 23 4.3 5.3 (3.1, 7.6) MM 39 9.4 4.2 (2.8, 5.5) Ovarian 91 32.1 2.8 (2.2, 3.4) Brain 11 3.2 3.5 (1.4, 5.6) Lung 113 65 1.7 (1.4, 2.1) Breast 791 579.5 1.4 (1.3, 1.5) CLL 34 17.4 2 (1.3, 2.6) Other 56 31.8 1.8 (1.3, 2.2) *RR ~95% confidence intervals are given in parentheses Table 2. t-MN in White Males 1st Cancer O E RR MN 180 17.8 10.1 (8.6, 11.6) ALL 14 0.9 15.1 (7, 23.2) Hodgkin's 42 6.4 6.6 (4.5, 8.6) NHL 344 69.6 4.9 (4.4, 5.5) MM 57 13.8 4.1 (3, 5.2) CLL 77 25.2 3.1 (2.4, 3.8) CIS 243 111.2 2.2 (1.9, 2.5) Head & Neck 31 11.3 2.7 (1.8, 3.7) Lung 130 71.5 1.8 (1.5, 2.1) Other 60 29.5 2 (1.5, 2.6) Testes 29 11.9 2.4 (1.5, 3.3) Brain 14 4.6 3.1 (1.4, 4.7) Oral 75 41.6 1.8 (1.4, 2.2) Bladder 215 158.9 1.4 (1.2, 1.5) Prostate 1331 1054.8 1.3 (1.2, 1.3) Rectal 93 64.2 1.4 (1.1, 1.7) Stomach 24 13.2 1.8 (1.1, 2.6) Table 3. t-MN in AA Females 1st Cancer O E RR MN 20 1.2 16.2 (8.9, 23.4) Hodgkin's 7 0.4 17.9 (4.4, 31.5) MM 10 2.2 4.6 (1.7, 7.5) Ovarian 9 1.8 5 (1.7, 8.3) NHL 11 3.2 3.5 (1.4, 5.6) Breast 73 41.6 1.8 (1.3, 2.2) CIS 34 21.2 1.6 (1.1, 2.2) Table 4. t-MN in AA Males 1st Cancer O E RR MN 14 0.8 17.9 (8.3, 27.4) NHL 20 2.4 8.4 (4.6, 12.1) Prostate 166 92.1 1.8 (1.5, 2.1) Other 8 1.7 4.7 (1.4, 8) CIS 9 2.3 4 (1.3, 6.6) Hodgkin's 5 0.4 11.8 (1.2, 22.4) Lung 13 4.7 2.8 (1.2, 4.3) Renal 10 3.2 3.1 (1.2, 5.1) Head & Neck 5 0.5 10.8 (1.1, 20.4) Disclosures Sekeres: Celgene: Membership on an entity's Board of Directors or advisory committees; Amgen Corp: Membership on an entity's Board of Directors or advisory committees; Boehringer-Ingelheim Corp: Membership on an entity's Board of Directors or advisory committees.
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Galezowski, Wlodzimierz, e Arnold Jarczewski. "Kinetics, isotope effects of the reaction of 1-(4-nitrophenyl)-1-nitroalkanes with DBU in tetrahydrofuran and chlorobenzene solvents". Canadian Journal of Chemistry 68, n.º 12 (1 de dezembro de 1990): 2242–48. http://dx.doi.org/10.1139/v90-345.
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The kinetics of the reaction of[Formula: see text](R = Me, Et, i-Pr; NPNE, NPNP, MNPNP respectively; L is H or D) with 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) base in tetrahydrofuran (THF) and chlorobenzene (CB) solvents are reported. The products of these proton transfer reactions are ion pairs absorbing at λmax = 460–480 nm. The equilibrium constants in THF were [Formula: see text]and in CB [Formula: see text]for NPNE, NPNP, MNPNP respectively. The thermodynamic parameters of the reactions are also quoted. The substrate reacts with DBU in both THF and CB solvents in a normal second-order proton transfer reaction. In the case of deuteron transfer, isotopic D/H exchange is much faster than internal return. The reactions show low values of enthalpy of activation ΔH* = 14.3, 18.1, 24.2 and 13.0, 15.1, 18.6 kJmol−1 for NPNE, NPNP, and MNPNP in THF and CB respectively, and large negative entropies of activation −ΔS* = 141, 139, 146; 140, 146, 160 J mol−1 deg−1 for the same sequence of substrates and solvents. The kinetic isotope effects are large, (kH/kD)20°c = 12.2, 13.0, 10.1; 12.9, 12.0, 10.2 for the above sequence of substrates and solvents, and show no difference with changes in either steric hindrance of the C-acids or polarity of the solvents. Keywords: proton transfer, kinetic isotope effect.
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Ma, Vincent, Kent Griffith, Jessica Waninger, Stephanie Daignault-Newton, Leslie Fecher, Ajjai Alva e Christopher Lao. "241 Clinical outcomes of metastatic melanoma patients with liver metastases treated with anti-PD-1 monotherapy versus combination ipilimumab/nivolumab". Journal for ImmunoTherapy of Cancer 8, Suppl 3 (novembro de 2020): A259—A260. http://dx.doi.org/10.1136/jitc-2020-sitc2020.0241.
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BackgroundRecent studies report of liver metastases (LM) as a poor prognostic factor in patients treated with immune checkpoint inhibitors (ICIs),1 but clinical outcomes associated with different ICI regimens remains uncertain. In this study, we investigate melanoma patients with and without LM and assess differential treatment outcomes associated with anti-PD-1 monotherapy and combination ipilimumab/nivolumab (I/N).MethodsWe conducted a single-center, retrospective review of advanced stage melanoma patients with and without LM treated with anti-PD-1 monotherapy (nivolumab or pembrolizumab) or I/N between 2012 and 2018. Overall survival (OS) and progression free survival (PFS) were measured from the first dose of treatment to date of death and clinical or radiographic progression, respectively. Univariate and multivariate analysis were performed using Cox proportional hazard (CPH) models and logistic regression models. Inverse probability of treatment weighting using propensity scores in CPH models was used to account for the following baseline covariates: age, ECOG performance status, BRAF status, pre-treatment LDH level, prior therapy status, and number and sites of metastases.Results327 patients were identified, 87 with LM and 240 without LM. Patients with LM was associated with worse PFS [HR: 2.1, 95% CI, 1.5 – 3.1] (figure 1) and OS [HR: 3.4, 95% CI, 2.2 – 5.2] (figure 2). Respective 3-year PFS and OS estimates associated with anti-PD-1 monotherapy were 21.8% and 28.7% in patients with LM (figure 3, figure 4); and 36.5% and 57.6% without LM (figure 5, figure 6). Respective 3-year PFS and OS estimates associated with I/N were 46.7% and 56.7% in patients with LM; and 58.0% and 74.4% without LM.Abstract 241 Figure 1Forest plot for progression free survival in all advanced stage (unresectable or metastatic) melanoma patients treated with anti-PD-1 monotherapy (nivolumab or pembrolizumab) or combination ipilimumab/nivolumab (Ipi/Nivo). n = 327Abstract 241 Figure 2Forest plot for overall survival in all advanced stage (unresectable or metastatic) melanoma patients treated with anti-PD-1 monotherapy (nivolumab or pembrolizumab) or combination ipilimumab/nivolumab (Ipi/Nivo). n = 327Abstract 241 Figure 3Kaplan-Meier curves comparing advanced stage melanoma patients with liver metastases treated with anti-PD-1 monotherapy (nivolumab or pembrolizumab) versus ipilimumab/nivolumab by progression free survival. n = 87Abstract 241 Figure 4Kaplan-Meier curves comparing advanced stage melanoma patients with liver metastases treated with anti-PD-1 monotherapy (nivolumab or pembrolizumab) versus ipilimumab/nivolumab by overall survival. n = 87Abstract 241 Figure 5Kaplan-Meier curves comparing advanced stage melanoma patients without liver metastases treated with anti-PD-1 monotherapy (nivolumab or pembrolizumab) versus ipilimumab/nivolumab by progression free survival. n = 240Abstract 241 Figure 6Kaplan-Meier curves comparing advanced stage melanoma patients without liver metastases treated with anti-PD-1 monotherapy (nivolumab or pembrolizumab) versus ipilimumab/nivolumab by overall survival. n = 240ConclusionsIn melanoma patients treated with PD-1 inhibitor-based regimens, the presence of LM leads to poorer survival outcomes. Our study suggests the poor prognosis associated with LM can be substantially mitigated by treatment with combination I/N over anti-PD-1 monotherapy. Further studies are warranted to investigate the anti-immunotherapy effect associated with LM.Ethics ApprovalThe study was approved by the University of Michigan institutional ethical guidelines and patients‘ consents were waived following Institutional Review Board protocol review (HUM00156014).ReferenceBilen MA, Shabto JM, Martini DJ, et al. Sites of metastasis and association with clinical outcome in advanced stage cancer patients treated with immunotherapy. BMC Cancer 2019; 19(1):857.
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Freysoldt, Bianca, Andrea Schnaiter, Luca Fischer, Michael O'Neill, Yvonne Zimmermann, Grit Hutter, Wolfgang Hiddemann e Martin H. Dreyling. "Cotargeting of PIM, PI3K and Mtor in Mantle Cell Lymphoma (MCL)". Blood 126, n.º 23 (3 de dezembro de 2015): 5120. http://dx.doi.org/10.1182/blood.v126.23.5120.5120.
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Abstract Introduction: Mantle cell lymphoma (MCL) comprises about 6% of all non-Hodgkin's lymphoma with a median survival of 3-5 years. Constitutional activation of the mTOR/AKT pathway has been identified in the majority of cases (Rudelius, Blood 2006). The pro-viral insertion in murine (PIM) lymphoma proteins are serine/threonine kinases which play a critical role in cell survival as well as proliferation and identifies a high risk patient cohort with MCL (Hsi, Leuk Lymphoma 2008). In this study we evaluated the efficiency and mode of action of a dual PIM/PI3K (IBL-202) and a triple PIM/PI3K/mTOR inhibitor (IBL-301) in MCL cell lines and primary cells. Methods: MCL cell lines (Granta 519, Jeko-1, Rec-1 and Mino), as well as primary MCL cells were exposed to the combined PIM-kinase/PI3K (IBL-202) and the PIM-kinase/PI3K/mTOR Inhibitor (IBL-301). Cell proliferation (trypan blue staining), cell apoptosis (Annexin V PE/7-AAD staining) and cell cycle (FACS) were investigated. Protein expression and phosphorylation status of different downstream proteins (Akt, GSK-3β, 4EBP1) as well as markers of apoptosis (PARP, Caspase 9) were analysed after 1h, 4h, 8h and 24h. Cell viability was assessed by CellTiter-Glo® assay after 48h. Results: Both inhibitors led to G1 arrest. At 500 nM, the triple inhibitor IBL-301 (19,8%) is in average slightly more efficacious than the dual-inhibitor IBL-202 (13,5%). Accordingly, IBL-301 had a much higher impact on cell proliferation than IBL-202 in all tested MCL cell lines (reduction by 48 - 93% vs 22 - 87%), possibly due to its mTOR inhibitory potential, although it may be also a more potent inhibitor of PIM and PI3K kinases. In addition, treatment with IBL-202 and IBL-301 induced cell apoptosis in Jeko-1, Rec-1 and Mino. Again, rate of apoptosis by IBL-301 was much higher (e.g. JEKO: 56% vs 13%) and could be achieved at lower concentrations in comparison to IBL-202. The differential impact on apoptosis could be confirmed based on PARP and Caspase 9 cleavage, which was higher after treatment with IBL-301 after 24h. In Jeko-1, Granta-519 and Mino both agents led to de-phosphorylation of Akt. Interestingly, this effect was more prominent in IBL-301 treated cell lines, supporting the mode of action via the PI3K-AKT pathway of both inhibitors. De-phosphorylation of GSK-3β was observed in all tested MCL cell lines with both inhibitors already during the first hour of exposure and was reversible thereafter. Primary MCL cells of 2 patients were treated with 62.5 nM IBL-202, 31.25 nM IBL-301 and single inhibitors of PIM (2.5 µM AZD1208), PI3K (1.25 µM idelalisib) and mTOR (5 nM temsirolimus). Viability after 48h was reduced by about 70% following IBL-301 exposure compared to 39% in IBL-202 treated samples. Both combined inhibitors were more potent than any of the single inhibitors. IBL-301 and IBL-202 decreased viability in a similar way as the combination of AZD1208, idelalisib +/- temsirolimus. Normal lymphocytes tolerated both inhibitors in various concentrations (62,5 - 500 nM). Conclusions: Triple inhibition of PIM kinases, PI3K and mTOR is very efficient in MCL cell lines as well as in primary MCL cells, exceeding dual inhibition of PIM kinases and PI3K. Thus, cotargeting PIM kinases, PI3K and mTOR may be a promising novel approach for clinical development in MCL. Disclosures O'Neill: Inflection Biosciences: Employment.
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Yahyapoor, Hasan, Yosoof Niknejad, Hormoz Fallah, Salman Dastan e Davood Barari Tari. "Yield Gap Estimation of Rapeseed (Brassica Napus L.) in Northern Iran". Romanian Agricultural Research 38 (2021): 251–57. http://dx.doi.org/10.59665/rar3827.
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Understanding yield-limiting traits can help researchers reduce yield gap, a key step in increasing yield and sustainability. This aim of research was monitoring 100 fields of farmers to identify the most important variables to enter into a CPA model (comparative performance analysis) for the yield gap in northern Iran in 2016 to 2017. Of the 150 variables studied in the first experiment, eight independent variables were chosen for the final model. In the yield model, the average and maximum yields were 2536 and 4265 kg ha-1 , respectively, with an estimated yield gap of 1729 kg ha-1 . This yield gap was related to seed usage, planting date, fallow and rice cover-crop equal’s 124, 101, 242 and 245 kg ha-1 includes 7.17, 5.84, 14 and 14.17% of total yield increase. The yield increasing related to the effect of crop rotation, potassium usage, nitrogen after flowering and top-dressing frequency was 212, 295, 314 and 196 kg ha-1 equals 12.26, 17.06, 18.16 and 11.34%. Accordingly, the model’s precision is good and can be applied both to estimate the quantity of yield gap and to determine the portion of each constraint in the yield variables. Importantly, as the calculated yield potential is reached based on actual data in each paddy field, the yield potential is attainable.
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นิยมเวช, ผศ ดร บุศรา. "การปฏิรูปการเรียนรู้ตลอดชีวิต: การใช้เทคโนโลยีเพื่อการเรียนรู้ที่มีประสิทธิภาพ". Interdisciplinary Academic and Research Journal 4, n.º 1 (15 de janeiro de 2024): 1–26. http://dx.doi.org/10.60027/iarj.2024.274130.
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ภูมิหลังและวัตถุประสงค์:เนื่องจากเทคโนโลยียังคงเป็นแรงผลักดันในขอบเขตของการศึกษาทำให้ความสัมพันธ์ทางชีวภาพระหว่างเครื่องมือที่เป็นนวัตกรรมกับการสอน และการเรียนรู้ที่มีประสิทธิภาพจึงปรากฏชัดเจนมากขึ้น จากการศึกษาเรื่อง การปฏิรูปการเรียนรู้ตลอดชีวิต : การใช้เทคโนโลยีเพื่อการเรียนรู้ที่มีประสิทธิภาพ โดยมีวัตถุประสงค์ของการวิจัยเพื่อ (1) สังเคราะห์การบูรณาการเทคโนโลยีในการเรียนรู้ และ (2) สังเคราะห์ความท้าทาย ความสำเร็จ แนวโน้ม และผลกระทบของเทคโนโลยีในการเรียนรู้ตลอดชีวิตในอนาคต ระเบียบวิธีการวิจัย: การวิจัยนี้ใช้รวบรวมและสังเคราะห์ข้อมูลทางวิชาการเพื่อสนับสนุนการเรียนรู้ตลอดชีวิตด้วยกระบวนการทบทวนวรรณกรรมด้วยระเบียบวิธีวิจัยที่เป็นระบบและมีแบบแผน โดยผลการวิจัยเน้นที่การ บูรณาการข้อมูลที่ครอบคลุมเกี่ยวกับเทคโนโลยีในการเรียนรู้ ความท้าทาย ความสำเร็จ แนวโน้มและผลกระทบ ของเทคโนโลยีในการเรียนรู้ตลอดชีวิต ซึ่งมีความสำคัญสำหรับผู้เรียน ผู้สอน ผู้บริหารและนักวิจัยที่ต้องการเรียนรู้และเท่าทันต่อเทคโนโลยีและการเรียนรู้ตลอดชีวิตที่กำลังเปลี่ยนแปลง ผลการศึกษา ผลการสังเคราะห์เรื่องการปฏิรูปการเรียนรู้ตลอดชีวิต : การใช้เทคโนโลยีเพื่อการเรียนรู้ที่มีโดยประสิทธิภาพ ประกอบด้วย 2 องค์ประกอบ ได้แก่ (1) องค์ประกอบที่ 1 การบูรณาการเทคโนโลยีในการเรียนรู้ ประกอบด้วย 1) เทคโนโลยีการเรียนรู้ (1.1) ระบบบริหารจัดการการเรียนรู้ (Learning Management System) (1.2) การจำลองเชิงโต้ตอบและห้องเรียนเสมือนจริง (1.3) แอปพลิเคชันการศึกษา 2) การเสริมศักยภาพผู้เรียนผ่านเทคโนโลยี (2.1) การเรียนรู้ส่วนบุคคล (2.2) การเข้าถึงและการไม่แบ่งแยก 3) เสริมสร้างความร่วมมือและการสื่อสาร (3.1) เครื่องมือการทำงานร่วมกัน (3.2) แพลตฟอร์มโซเชียลมีเดีย (3.3) เทคโนโลยีการสื่อสาร 4) การประเมินและผลตอบรับในยุคดิจิทัล (4.1) วิธีการประเมินที่ขับเคลื่อนด้วยเทคโนโลยี และ (4.2) กลไกการตอบรับแบบเรียลไทม์ (2) องค์ประกอบที่ 2 ความท้าทาย ความสำเร็จ แนวโน้ม และผลกระทบ ของเทคโนโลยีในการเรียนรู้ตลอดชีวิตในอนาคต ประกอบด้วย 1) ความท้าทายและข้อพิจารณา (1.1) การเข้าถึงและความเสมอภาค (1.2) ความรู้ด้านดิจิทัล (1.3) ข้อจำกัดที่อาจเกิดขึ้น 2) แนวทางปฏิบัติที่ดีที่สุดสู่ความสำเร็จ (2.1) การเน้นย้ำความสำเร็จในการบูรณาการเทคโนโลยี (2.2) การตรวจสอบผลลัพธ์เชิงบวกและบทเรียนที่ได้รับ 3) แนวโน้มและผลกระทบในอนาคต (3.1) เทคโนโลยีเกิดใหม่ และ (3.2) ข้อพิจารณาสำหรับผู้มีส่วนได้เสีย สรุปผล: การศึกษาเน้นถึงความสำคัญของบทบาทเทคโนโลยีในการเรียนรู้ตลอดชีวิต ที่ครอบคลุมทั้งการบูรณาการระบบการจัดการการเรียนรู้และการพัฒนาการเรียนรู้โดยใช้แบบจำลองเชิงโต้ตอบ ไปจนถึงความท้าทาย ความสำเร็จ แนวโน้มและผลกระทบในอนาคต ที่เกี่ยวข้องกับการนำเทคโนโลยีมาประยุกต์ใช้ในการศึกษาด้วยวิธีการต่าง ๆ เพื่อปรับปรุงคุณภาพของประสบการณ์การเรียนรู้ตลอดชีวิต การสรุปงานวิจัยนี้นำเสนอภาพรวมที่ครอบคลุมและเป็นรากฐานสำหรับการส่งเสริมการเรียนรู้ตลอดชีวิตผ่านเทคโนโลยีอย่างมีประสิทธิภาพ
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Andryani, Novy, e Inggit Prastiawan. "PENERAPAN MODEL TAKE AND GIVE PADA PEMBELAJARAN TARI MAK INANG PULAU KAMPAI UNTUK MENINGKATKAN APRESIASI SISWA KELAS X DI SMA NEGERI 1 KISARAN". Gesture: Jurnal Seni Tari 9, n.º 2 (7 de dezembro de 2020): 250. http://dx.doi.org/10.24114/senitari.v9i2.20453.
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ABSTRACTThis study aims to describe the application ot the Take and Give model in the Mak Inang dance lessons in Kampai Island inaccordance with KD 3.1 which is to understand the concepts, techniques and procedures in imitating the basic dance movement in SMA Negeri 1 Kisaran. The theories used in this research are Take and Give model theory. The Take and Give model theory used in this study is a theory according to Miftahul Huda (2014: 242-243). The time spent in this study was three months, starting from October to December. The location of the study was conducted at SMA Negeri 1 Kisaran. The population of the research is all of class X which amounts to seven classes with a total of two hundred fifty two students. The sample is thirty-six students in class X IPA-1. This research method is quantitative with a type of quasi-experimental research in one group pretest-posttest. Data collection techniques are done by observation, documentation and literature study. The results of the study note that there are eight stages of use and give according to the author’s understanding based on Miftahul Huda consisting of (1) the teacher preparing cards as many as the number of students, (2) the teacher conditions the class, (3) the teacher explains the material using power points according to KD 3.1 namely understanding the concepts, techniques and procedures in imitating the basic dance moves, (4) the teacher distributes cards and gives each student time to memorize the material contained on the card, (5) the teacher directs students to look for pairs according to the cards that have been written by the teacher before, (6) the teacher gives question whose answers are in according with the information received from his partner, (7) the teacher does according to the steps, (8) the teacher closes the lesson. T test results obtained in this study are T count greater than T table (78,19621117 > 1,997729633). T test was carried out after the pretestand posttest values were abtained, where the pretestwas carried out before the treatment (lecture method) with the acquisition of an average pretestvalue of 56,16, whilw the posttestwas carried out after the treatment (take and give model) with the acquisition of an average value posttestof 83,47. Thus obtained an increase in the value of student appreciation reached 33%, this shows that through the application of the Take and Give model, the appreciation of students of class X to the Mak Inang dance material in Kampai Island according to KD 3.1 increased. Keywords: Take and Give Models, Learning, Dance Appreciation. ABSTRAKPenelitian ini bertujuan untuk mendeskripsikan penerapan model Take and Give pada pembelajaran tari mak inang pulau kampai sesuai KD. 3.1 yaitu memahami konsep, teknik dan prosedur dalam menirukan ragam gerak dasar tari di SMA Negeri 1 Kisaran. Teori-teori yang digunakan dalam penelitian ini yaitu teori model Take and Give, teori pembelajaran, dan teori apresiasi seni tari. Teori model Take and Give yang digunakan dalam penelitian ini adalah teori menurut Miftahul Huda (2014: 242-243). Waktu yang digunakan dalam penelitian ini selama tiga bulan, dimulai bulan Oktober sampai Desember. Lokasi Penelitian dilakukan di SMA Negeri 1 Kisaran. Populasi penelitian yaitu seluruh kelas X yang berjumlah 7 kelas dengan jumlah siswa sebanyak 252 orang. Sampelnya yaitu siswa yang berada di kelas X IPA-1 yang berjumlah 36 orang. Metode penelitian ini adalah kuantitatif dengan jenis penelitian quasi eksperiment dalam one group pretest-posttest design. Teknik pengumpulan data dilakukan dengan observasi, dokumentasi, dan studi kepustakaan. Hasil penelitian diketahui bahwa ada 8 tahapan Take and Give menurut pemahaman penulis berdasarkan Miftahul Huda terdiri dari (1) guru menyiapkan kartu sebanyak jumlah siswa (2) guru mengkondisikan kelas (3) guru menjelaskan materi menggunakan power point sesuai KD 3.1 yaitu memahami konsep, teknik, dan prosedur dalam menirukan ragam gerak dasar tari (4) guru membagikan kartu dan memberi waktu kepada masing-masing siswa untuk menghafal materi yang terdapat pada kartu (5) guru mengarahkan siswa untuk mencari pasangan sesuai dengan kartu yang telah ditulis oleh guru sebelumnya (6) guru memberikan pertanyaan yang jawabannya sesuai dengan informasi yang diterima dari pasangan (7) guru melakukan sesuai langkah-langkah (8) guru menutup pelajaran. Hasil tes uji T yang diperoleh dalam penelitian ini yaitu thitung lebih besar dari ttabel (78,19621117 > 1,997729633). Uji T dilakukan setelah diperoleh nilai pretest dan posttest, di mana pelaksanaan pretest dilakukan sebelum treatment (metode ceramah) dengan perolehan nilai rata-rata pretest sebesar 56,16, sedangkan pelaksanaan posttest dilakukan setelah treatment (model take and give) dengan perolehan nilai rata-rata posttest sebesar 83,47. Dengan demikian diperoleh peningkatan nilai apresiasi siswa mencapai 33%, ini menunjukkan bahwa melalui penerapan model Take and Give, apresiasi siswa kelas X terhadap materi tari mak inang pulau kampai sesuai KD 3.1 meningkat. Kata Kunci: Model Take and Give, Pembelajaran, Apresiasi Seni Tari.
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Schumer, Benjamin N., Hexiong Yang e Robert T. Downs. "Natropalermoite, Na2SrAl4(PO4)4(OH)4, a new mineral isostructural with palermoite, from the Palermo No. 1 mine, Groton, New Hampshire, USA". Mineralogical Magazine 81, n.º 4 (agosto de 2017): 833–40. http://dx.doi.org/10.1180/minmag.2016.080.133.
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AbstractNatropalermoite, ideally Na2SrAl4(PO4)4(OH)4, the Na-analogue of palermoite, is a new mineral from the Palermo No. 1 mine, Groton, New Hampshire, USA. Associated minerals are palermoite, eosphorite and quartz. Natropalermoite crystal sare prismatic with striations parallel to the direction of elongation (the a axis) up to 200 μm × 50 μm × 45 μm in size. The mineral is colourless, transparent with a white streak and vitreous lustre and is visually indistinguishable from palermoite. It is brittle with subconchoidal fracture and has a Mohs hardness of 5.5. Cleavage is perfect on {001}, fair on {100} and no parting was observed. The calculated density is 3.502 g cm–3. Natropalermoite is biaxial (–), α = 1.624(1), β = 1.641(1), γ = 1.643(1) (589nm), 2Vmeas = 43(4)°, 2Vcalc = 38°. An electron microprobe analysis yielded an empirical formula (based on 20 O apfu) of (Na1.69Li0.31)∑2.00(Sr0.95Mg0.04Ca0.02Ba0.01)∑1.02(Al3.82Mn0.03Fe0.03)∑3.88(P1.01O4)4(OH)4.Natropalermoite is orthorhombic, space group Imcb, a = 11.4849(6), b = 16.2490(7), c = 7.2927(4) Å, V = 1360.95(17) Å3, Z = 4. Natropalermoite is isotypic with palermoite, but substitution of the larger Na for Li results in substantial increase of the b cell parameter. Four of the seven Na–O distances are longer than their equivalents in palermoite, resulting in a more regular 7-fold coordination polyhedron about Na. The eight strongest peaks in the calculated X-ray powder diffraction are [dcalc(Å),Irel%, (hkl)]: [3.128, 100, (321)], [4.907, 68, (121)], [3.327, 48, (022)], [4.689, 45, (220)], [3.078, 45, (202)], [2.453, 38, (242)], [2.636, 35, (411)], [2.174, 35, (422)].
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Mahalingam, Devalingam, Benjamin Tubb, John J. Nemunaitis, Putao Cen, Julie Haewon Rowe, John Sarantopoulos, Michael R. Kurman, Victoria Allgood e Luis T. Campos. "Clinical activity and correlative DCE-MRI imaging of G-202, a thapsigargin-based prostate-specific membrane antigen-activated prodrug, in progressive hepatocellular cancer." Journal of Clinical Oncology 33, n.º 3_suppl (20 de janeiro de 2015): 301. http://dx.doi.org/10.1200/jco.2015.33.3_suppl.301.
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301 Background: G-202 is a thapsigargin-based prodrug whose cytotoxic activity is blocked by a masking peptide that is cleaved by prostate-specific membrane antigen (PSMA), a membrane-bound protease expressed in prostate cancer and the endothelium of tumor vasculature but not in most other tissues or normal tissue vasculature. In a Phase I study of G-202, prolonged disease stabilization was observed in the subset of patients with hepatocellular carcinoma (HCC) and prompted development of a Phase II study to further evaluate activity of G-202 in patients with HCC who have progressed on sorafenib. Methods: G-202 is administered by iv infusion on Days 1, 2 and 3 of a 28-day cycle; prophylactic hydration is administered with infusion to ameliorate incidence of creatinine elevations. HCC is typically highly-vascularized, and DCE-MRI is performed in consenting patients at baseline and after treatment on approximately Day 6 of Cycle 2 to evaluate possible effects of G-202 on blood flow metrics in hepatic lesions. DCE-MRI is a non-invasive method of investigating vascular structure and function and is sensitive to alterations in vascular permeability and blood flow. DCE-MRI measurements were made on 1.5 Tesla MRI and the volume transfer coefficients, Ktrans, of HCC tumor lesions were calculated using arterial input function derived from signal in abdominal aorta. Results: Among the 22 patients treated to date, G-202 related SAEs in this patient population have been creatinine increase/acute renal failure/acute kidney injury (3 pts) and congestive heart failure (1 pt). While objective responses (CR, PR) have not been observed in these patients with advanced disease, the rate of disease stabilization has been remarkable, with >70% of patients exhibiting SD. In patients undergoing DCE-MRI, an average 56% decrease in Ktranshas been observed after administration of G-202. Conclusions: G-202 is generally well-tolerated and promotes disease stabilization in patients with advanced HCC who have progressed on sorafenib. DCE-MRI findings of decreased tumor Ktrans values suggests that G-202 reduces early arterial blood flow in hepatic lesions. Clinical trial information: NCT01777594.
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Sheikh, Sameena, R. K. Behl, S. S. Dhanda e Ashwani Kumar. "Gene effects for different metric traits under normal and high temperature stress environments in wheat (T. aestivum L. Em Thell)". South Pacific Journal of Natural and Applied Sciences 27, n.º 1 (2009): 38. http://dx.doi.org/10.1071/sp09007.
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The present investigation was conducted to analyze gene effects for grain yield and its components under two different environments. Nine wheat genotypes were selected to generate the experimental material comprised six parental and segregating generations (P1, P2, F1, F2, BC1 and BS1 of BC1 of each of the following six crosses – PBW 343 x WH 283, PBW 343 x WH 542, PBW 343 x PBW 435, UP 2565 x UP 2425, EIGN 1 x Raj 3765 and EIGN 8 x UP 2425. Joint scaling tests revealed the presence of epitasis. Six parameter model revealed the significance of additive gene effects (d) for biological and grain yield and their components in most of the crosses. The relative magnitude of (h) was higher than (d) in all the crosses for most of the characters while additive x additive (i) effects appeared to be significant for grain yield per plant (E1) and number of grain per spike (E2) in PBW 343 x WH 283. Significant (i) type of interaction was recorded in PBW 343 x WH 542 for number of grain per spike (E1), number of tillers per plant (E2) in PBW 343 x PBW 435 and for 1000-grain weight in UP 2565 x UP 2425. Pedigree method and simple selection in crosses like PBW 343 x PBW 435, UP 2565 x UP 2425, PBW 343 x WH 283 and PBW 343 x WH 542 should be used for improvement of traits governed by additive and additive x additive gene effect.
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Jasonsmith, J. F., W. Maher, A. C. Roach e F. Krikowa. "Selenium bioaccumulation and biomagnification in Lake Wallace, New South Wales, Australia". Marine and Freshwater Research 59, n.º 12 (2008): 1048. http://dx.doi.org/10.1071/mf08197.
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Selenium concentrations were measured in water, sediments and organisms inhabiting a freshwater coal power station cooling reservoir. Se concentrations found were: water, 1.9 ± 2 μg L–1; sediment, 7 ± 1 μg g–1; phytoplankton, 3.4 μg g–1; zooplankton, 5.3 μg g–1; epiphytic algae, 1.3 ± 0.2 μg g–1; benthic algae, 8 ± 2 μg g–1; macrophyte leaves, 2.7–2.8 μg g–1; macrophyte roots, 0.5–6.5 μg g–1; detritus, 10 μg g–1; Oligochaeta, 11 μg g–1; Corbiculidae, 1.1 μg g–1; Insects, 3.7–8.3 μg g–1; Gastropoda, 3.2 μg g–1; Crustacea, 3.1–6 μg g–1; whole fish, 2.2–13 μg g–1; and fish liver, 134–314 μg g–1. Bioconcentration factors were similar to those found in aquatic ecosystems with comparable Se concentrations in the water column. A food web was constructed with four main food chains (phytoplankton, epiphytic algae, benthic algae and sediment/detrital), with fish fed from multiple pathways. Biomagnification only occurs along food chains for flathead gudgeons and rainbow trout. Se concentrations in food sources were above the 3 μg g–1 dietary Se level considered to induce teratogenesis in fish spawning. Flathead gudgeons were found to be suffering teratogenesis and rainbow trout showed no evidence of teratogenesis.
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Paul, C., E. van der Logt, Pieter H. Reitsma e Rogier M. Bertina. "Alternative Splicing Is Responsible for the Presence of Two Tissue Factor mRNA Species in LPS Stimulated Human Monocytes". Thrombosis and Haemostasis 67, n.º 02 (1992): 272–76. http://dx.doi.org/10.1055/s-0038-1648424.
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SummaryAlthough normally absent from the surface of all circulating cell types, tissue factor (TF) can be induced to appear on circulating monocytes by stimulants like bacterial lipopolysaccharide (LPS) and phorbolesters. Northern analysis of RNA isolated from LPS stimulated human monocytes demonstrates the presence of 2.2 kb and 3.1 kb TF mRNA species. The 2.2 kb message codes for the TF protein. As demonstrated by Northern blot analysis with a variety of TF gene probes, the 3.1 kb message arises from an alternative splicing process which fails to remove 955 bp from intron 1. Because of a stop codon in intron 1 no TF protein is produced from the 3.1 kb transcript. This larger transcript should therefore not be taken into account when comparing TF gene transcription and TF protein levels.
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Villalta Puig, Gonzalo, e Cédric Darcis. "The Development of European Union Implied External Competence: the Court of Justice and Opinion 1/03". Anuario Español de Derecho Internacional 25 (16 de agosto de 2018): 469–99. http://dx.doi.org/10.15581/010.25.28336.
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I. INTRODUCTION. II. IMPLIED EXTERNAL COMPETENCE WITH SECONDARY LEGISLATION. 2.1. Implied External Competence before Opinion 1/03. 2.2.Implied External Competence after Opinion 1/03. III. IMPLIED EXTERNAL COMPETENCE WITHOUT SECONDARY LEGISLATION. 3.1. Implied External Competence before Opinion 1/03. 3.2. Implied External Competence after Opinion 1/03. IV. CONCLUSION
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Tredan, Olivier, Veronique Corset, Qing Wang, Romain Varnier, Camille Pacaud, Alexia Torroja, Nicolas Luppi et al. "Routine molecular screening of advanced refractory cancer patients: An analysis of the first 2490 patients of the ProfiLER study." Journal of Clinical Oncology 35, n.º 18_suppl (20 de junho de 2017): LBA100. http://dx.doi.org/10.1200/jco.2017.35.18_suppl.lba100.
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LBA100 Background: ProfiLER (NCT01774409) is a molecular profiling clinical trial exploring cancer cell genomic alterations in pts with advanced disease to guide treatment. Methods: Pts with confirmed diagnosis of advanced cancers are eligible. DNA extracted from either archival or fresh collected tumor samples was analyzed by targeted exon sequencing of 60 cancer related genes and whole genome array comparative genomic hybridization (CGH). A multidisciplinary molecular board analyzes genomic data and recommends molecular targeted therapies (MTT) when actionable alterations are found. Results: As of Jan 2017, 2490 pts (55% female, median age 59, range 1-90) were consented; 1826 (73.3%) tumors were analyzed, 301 (12%) are ongoing (not done in 363 pts (14.6%) for technical issues). Tumor types were colorectal (10.3%), gyneco (9.5%), breast (8.8%), head & neck (7.1%) carcinomas, sarcomas (7.1%) and brain tumors (6.5%). 940/1826 pts (51.5%) had at least 1 actionable mutation (AM): 579 pts with only one AM, while 358 with 2 or more AM (up to 6). Mutations (including substitutions and small indels), amplifications and homozygous deletions (HD) were observed respectively in 55.3%, 42.1% and 25.5% of tumor samples. The most common AM were on KRAS (n = 156; 8.5%), PIK3CA (n = 150; 8.2%), CDKN2A HD (n = 174; 9.5% ), PTEN HD (n = 49, 2.7%), CCND1 (n = 97; 5.3%), FGFR1 (n = 56; 3.1%), MDM2 (n = 53; 2.9%), HER2 (n = 42; 2.3%) and HER1(n = 41; 2.2%). MTT were recommended in 644 pts. Among them, 101 (gyn [28%], GI [18%], breast [12%]) initiated a recommended MTT. Collection of treatment data is ongoing for 202 pts. MTT received were mTOR inhibitors (39%), anti-angiogenic TKI (21%), EGFR TKI (9.8%), inhibitors of cell cycle (6.9%). Best responses were CR (n = 2, 2.3%), PR (n = 13, 15.1%), SD (n = 29, 33.7%), PD (n = 42, 48.8%), with a median PFS of 2.8 months (95% IC: 2.2-3.5). 24% are alive progression free at 6 months. Updated data will be presented at the meeting. Conclusions: In this series of 2490 cancer pts, CGH and NGS identified actionable alterations on 51% of pts, with treatment recommendation in 35%. Most patients treated derived benefit from the recommended MTT, but these represent a minority of the whole population screened. Clinical trial information: NCT01774409.
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Kourtit, Karima. "Planet of Cities, by ShlomoAngel. 2012. Cambridge, MA: Lincoln Institute of Land Policy. 341 + xvi. ISBN 978-1-55844-245-0, paper, $40." Journal of Regional Science 54, n.º 1 (janeiro de 2014): 161–62. http://dx.doi.org/10.1111/jors.12091.
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Polikarchyk, Vladimir A., Andrey Yu Potapov, Victoria E. Razumova, Viktor N. Verezhnikov, Khidmet S. Shikhaliev, Viktor Ph Kostryukov e Nadezhda V. Stolpovskaya. "ВЭЖХ-масс-спектрометрический анализ трехкомпонентной реакции с участием 4-гидрокси-2(1H)-хинолона и различных аминоазолов". Сорбционные и хроматографические процессы 20, n.º 6 (21 de dezembro de 2020): 734–41. http://dx.doi.org/10.17308/sorpchrom.2020.20/3141.
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Современный рациональный дизайн структур органических соединений требует высокой эф-фективности вследствие необходимости одновременного повышения молекулярной сложности и ми-нимизации числа стадий синтетических процедур. Эти проблемы становятся еще более значимыми при конструировании различных полиазагетероциклических структур, в том числе с пиримидиновым скелетом, являющимся одним из самых распространенных фрагментов в структурах природных и синтетических биологически активных соединений. Поэтому, актуальными являются проблемы, свя-занные с поиском новых селективных синтетических подходов к построению пиримидиновых гете-роциклических систем, изучением механизмов их образования, реакционной способности и дальней-шей направленной функционализации, выбора доступных реагентов для их синтеза.В настоящее время получение новых гетероциклических соединений мультикомпонентными методами, рассматривается как наиболее перспективное, с точки зрения создания комбинаторных библиотек для высокопроизводительного биологического скрининга, позволяющего in vitro одновре-менно протестировать тысячи соединений на различные виды биоактивности. Основным направлени-ем решения данных задач является модернизация синтетических процедур посредством внедрения методологий мультикомпонентных и каскадных процессов.Кроме этого, основной проблемой при исследовании трехкомпонентных каскадных реакций с использованием различных полинуклеофильных матриц является определение последовательности процессов, приводящих к целевым продуктам. Для реализации этой задачи необходимы сведения о строении промежуточных соединений, возможность индивидуализации которых традиционными препаративными методами весьма затруднительна.Методом ВЭЖХ совмещенной с масс-спектрометрией изучен маршрут трехкомпонентного взаимодействия аминоазолов с 4-гидрокси-2(1H)-хинолононом и диметилацеталем N,N-диметилформамида. Показано, что ожидаемые азолопиримидо[5,4-с]хинолин-6(7Н)-оны образуются лишь в минорном количестве, а основным продуктом этого взаимодействия является 3,3’-бихинолин-2,2’,4,4’(1,H,1’H,3H,3’H)-тетрон, образующийся при окислительной димеризации 4-гидрокси-2(1H)-хинолонона под действием кислорода воздуха. При замене диметилацеталя N,N-диметилформамида на триэтилортоформиат был выделен исключительно 3,3’-бихинолин-2,2’,4,4’(1,H,1’H,3H,3’H)-тетрон. Исследование состава маточного раствора показал трудноразделимую смесь, в которой при-сутствовали в остаточных количествах исходные реагенты 3,3’-бихинолин-2,2’,4,4’(1,H,1’H,3H,3’H)-тетрон, а также целевой азолопиримидо[5,4-с]хинолин-6(7Н)-он