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Flynn, Leo. "Joined Cases C-92/92 and C-326/92, Collins v. Imtrat Handelsgesellschaft mbH and Patricia Im- Und Export Verwaltungsgesellschaft mbH v. EMI Electrola GmbH, Judgmen". Common Market Law Review 32, Issue 4 (1 de agosto de 1995): 997–1011. http://dx.doi.org/10.54648/cola1995046.
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Al Sheikh, O. G., J. I. Al Samarrai, M. M. Al Sumaidaie, S. A. Mohammad e A. A. Al Dujaily. "Immunization coverage among children born between 1989 and 1994 in Saladdin Governorate, Iraq". Eastern Mediterranean Health Journal 5, n.º 5 (15 de outubro de 1999): 933–40. http://dx.doi.org/10.26719/1999.5.5.933.
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We assessed vaccination coverage rates among children born between 1989 and 1994 [0-2 years of age]and tried to find the underlying causes of incomplete immunization. Of 662 children surveyed, 326 were from Tikrit city [urban]and 336 were from three rural villages. The coverage rates for BCG, DPT-OPV [first dose], DPT-OPV [second dose], DPT-OPV [third dose], measles, MMR, and DPT-OPV [first booster]were 97%, 97%, 94%, 92%, 83%, 70% and 59% respectively in Tikrit city; in rural areas they were 92%, 65%, 57%, 41%, 42%, 32%, and 25% respectively. The most common causes of incomplete immunization were unawareness and ignorance for both urban and rural areas. The percentage of children completely immunized declined between 1989 and 1994, both in urban and rural areas
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مصطفى مداوي, أ. احلام. "السياحة في ليبيا "دراسة في جغرافية السياحة"". المجلة الليبية العالمية, n.º 65 (14 de junho de 2024): 1–23. http://dx.doi.org/10.37376/glj.vi65.5821.
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تهتم هذه الدراسة من خلال السؤال المطروح في المشكلة البحثية بالتعرف على اهم المقومات الطبيعية للسياحة في ليبيا ، و توضيح الكيفية التي تتوزع بها تسهيلات الطلب السياحي وابراز الاتجاه العام الذي خلفه هذا التوزيع ، كما اعتمدت الدراسة في مناقشتها للموضوع على مجموعة من المناهج تهدف في مجملها الى توضيح التطور التاريخي للظاهرة وتكوين تصور ذهني متكامل عن خصائصها من خلال وصفها ومقارنة مفرداتها لاكتشاف الاختلافات المكانية في توزيعها وخصائصها ، وبعد معالجة البيانات بالأساليب الاحصائية و المكانية توصلت الدراسة الى مجموعة من النتائج التي تبين من خلالها ان المناطق الشمالية المطلة على البحر المتوسط أكثر ملائمة من الناحية المناخية لحركة السياحة في أغلب فترات السنة ، بينما نجد أن المناطق الصحراوية يمكن أن تكون ملائمة مناخيا لحركة النشاط السياحي في فصل الشتاء ، حيث تتراوح درجات الحرارة بين ( 18.2 م◦- 16.2 م◦) ، و تتراوح نسبة الرطوبة بين (%17-52% ).، اما بالنسبة لأعداد السياح القادمين من خارج البلاد يلاحظ ان اكبر عدد تم تسجيله في سنة 1998 والذي بلغ 919000 مسافر ، اما اقل عدد فقد تم تسجيله في سنة 2002 والذي بلغ 20075 مسافر، اما بالنسبة للطاقة الفندقية في ليبيا فقد بدأت في التطور منذ منتصف الستينات ، ففي سنة 1964 بلغ عدد الفنادق54 فندقا ، استمرت الزيادة في عدد الفنادق لتبلغ 326 فندقا وذلك في سنة 2018 ، اما بالنسبة لاتجاهات حركة السياحة الدولية إلى ليبيا فهي شملت جميع القارات موزعة على 92 دولة حسب احصائية 2008م مع تفاوت حجم كل اتجاه.، حيث تأتي قارة أوروبا في مقدمة الدول المصدرة للسياح إلى ليبيا بعدد 92 دولة أوربية و بعدد 38658 سائح و بنسبة 92% من اجمالي السياح القادمين إلى ليبيا ، ثم قارة أسيا بعدد 20 دولة أسيوية ، العدد الأكبر من الأفواج السياحية تفضل المناطق الساحلية عن الصحراوية إلا أن التفاوت ليس بالكبير.
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Santos, Haroldo Alfredo. "Hemorroidectomia híbrida: uma nova abordagem no tratamento das hemorróidas mistas". Revista Brasileira de Coloproctologia 26, n.º 4 (dezembro de 2006): 377–88. http://dx.doi.org/10.1590/s0101-98802006000400002.
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Este trabalho tem por objetivo apresentar uma nova abordagem mini-invasiva das Hemorróidas Mistas, a Hemorroidectomia Híbrida, que consiste na associação da Ligadura Elástica (LE) das Hemorróidas Internas com a ressecção complementar dos Plicomas Externos sob anestesia local. Num universo de 326 cirurgias orificiais realizadas na Proctoclínica num período de 4 anos, 300 (92%) foram submetidos a procedimentos mini-invasivos, 223 (68,40%) foram submetidos a LE como tratamento exclusivo e 77 (23,60%) à Hemoirroidectomia Híbrida) e 26 (8%) foram submetidos a outros procedimentos cirúrgicos (Hemorroidectomias a Milligan-Morgan, Fistulectomias etc. A abordagem proposta permite absenteísmo mínimo ao trabalho, mini-invasividade e baixa morbidade pós-operatória, ressaltando-se ainda a realização ambulatorial, excelente tolerabilidade e baixos custos.
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Van Gheluwe, Bart, Kevin A. Kirby, Philip Roosen e Robert D. Phillips. "Reliability and Accuracy of Biomechanical Measurements of the Lower Extremities". Journal of the American Podiatric Medical Association 92, n.º 6 (1 de junho de 2002): 317–26. http://dx.doi.org/10.7547/87507315-92-6-317.
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The reliability of biomechanical measurements of the lower extremities, as they are commonly used in podiatric practice, was quantified by means of intraclass correlation coefficients (ICCs). This was done not only to evaluate interrater and intrarater reliability but also to provide an estimate for the accuracy of the measurements. The measurement protocol involved 30 asymptomatic subjects and five raters of varying experience. Each subject was measured twice by the same rater, with the retest immediately following the test. The study demonstrated that the interrater ICCs were quite low (≤0.51), except for the measurements of relaxed calcaneal stance position and forefoot varus (both 0.61 and 0.62 for left and right, respectively). However, the intrarater ICCs were relatively high (>0.8) for most raters and measurement variables. Measurement accuracy was moderate between raters. (J Am Podiatr Med Assoc 92(6): 317-326, 2002)
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Wiguna, Reza Indra, e Haris Suhamdani. "Impact of the ‘Nola J Pender’ Health Promotion Model Towards the Level of Community Compliance in Implementing COVID-19 Health Protocols". Jurnal PROMKES 10, n.º 1 (23 de março de 2022): 85. http://dx.doi.org/10.20473/jpk.v10.i1.2022.85-92.
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Background: Indonesia is facing COVID-19 waves in almost all provinces. Based on data from the COVID-19 Response Acceleration Task Force, there were 57 districts with a compliance level of wearing a mask by less than 60%, while 51 districts had a compliance level of keeping distance and avoiding crowds by less than 60%. Objective: The aim of this study is to analyze the effect of the Health Promotion Model (HPM) in increasing people’s compliance level on the implementation of COVID-19 health protocols. Methods: Quasi-experiment with a single-group interrupted time-series design was conducted in June-September 2021 in West Lombok district and Central Lombok district, West Nusa Tenggara Province. The samples were 326 respondents from purposive sampling with criteria: adult group or elderly of the healthy category and not being positively confirmed of COVID-19. Results: There was a significant effect of HPM in increasing people’s compliance level on the implementation of the health protocols (5M) measured by the Wilcoxon Signed Rank Test (p-value <0,05). The health protocols (5M) included wearing a mask (p=0,000), keeping distance (p=0,000), cleaning hands (p=0,000), avoiding crowds (p=0,000), and reducing mobility (p=0,000). Conclusion: The Health Promotion Model (HPM) is a strategy to conduct health promotion activities that can influence the attitudes and behaviors of community groups marked by increasing knowledge and awareness of people in the Lombok area for the implementation of the 5M COVID-19 health protocols.
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Nischwitz, C., A. S. Csinos, S. W. Mullis, L. L. Hickman, K. L. Stevenson e R. D. Gitaitis. "Effect of Transplant Age, Tobacco Cultivar, Acibenzolar-S-Methyl, and Imidacloprid on Tomato Spotted Wilt Infection in Flue-Cured Tobacco". Plant Disease 92, n.º 11 (novembro de 2008): 1524–28. http://dx.doi.org/10.1094/pdis-92-11-1524.
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Tomato spotted wilt virus (TSWV) has become the most serious problem in flue-cured tobacco in Georgia and is a growing problem in other tobacco-growing areas in the United States. The effects of transplant age (6 to 10 weeks), tobacco cultivar (K-326 and NC-71), and preplant applications of acibenzolar-S-methyl (ASM) and the insecticide imidacloprid (IMD) were evaluated on levels of TSWV infection, number of symptomatic plants, and yield in field trials over 4 years. In all 4 years and in four of five trials, treatment of transplants with ASM and IMD resulted in fewer symptomatic plants, smaller areas under the disease progress curve (AUDPC), and higher yields compared with the nontreated controls. There were no consistent effects of transplant age or cultivar on number of symptomatic plants or systemic infections, AUDPC, or yield. Treatment of transplants with ASM and IMD can significantly reduce the number of symptomatic plants in the field and substantially increase yields and value per hectare.
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HASEMAN, J. "An examination of the association between maximum-tolerated dose and carcinogenicity in 326 long-term studies in rats and mice". Fundamental and Applied Toxicology 19, n.º 2 (agosto de 1992): 207–13. http://dx.doi.org/10.1016/0272-0590(92)90153-9.
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Cierzynski, Th. "Harmon, P., D. King: Expertensysteme in der Praxis. Perspektiven, Werkzeuge, Er-fahrungen. 2., ergänzende Auflage R. Oldenbourg Verlag, München – Wien 1987, 326 S., 92 Abb., 17 Tab". Biometrical Journal 30, n.º 7 (1988): 870. http://dx.doi.org/10.1002/bimj.4710300731.
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Mateen, Bilal Akhter, Harrison Wilde, John M. Dennis, Andrew Duncan, Nick Thomas, Andrew McGovern, Spiros Denaxas, Matt Keeling e Sebastian Vollmer. "Hospital bed capacity and usage across secondary healthcare providers in England during the first wave of the COVID-19 pandemic: a descriptive analysis". BMJ Open 11, n.º 1 (janeiro de 2021): e042945. http://dx.doi.org/10.1136/bmjopen-2020-042945.
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ObjectiveIn this study, we describe the pattern of bed occupancy across England during the peak of the first wave of the COVID-19 pandemic.DesignDescriptive survey.SettingAll non-specialist secondary care providers in England from 27 March27to 5 June 2020.ParticipantsAcute (non-specialist) trusts with a type 1 (ie, 24 hours/day, consultant-led) accident and emergency department (n=125), Nightingale (field) hospitals (n=7) and independent sector secondary care providers (n=195).Main outcome measuresTwo thresholds for ‘safe occupancy’ were used: 85% as per the Royal College of Emergency Medicine and 92% as per NHS Improvement.ResultsAt peak availability, there were 2711 additional beds compatible with mechanical ventilation across England, reflecting a 53% increase in capacity, and occupancy never exceeded 62%. A consequence of the repurposing of beds meant that at the trough there were 8.7% (8508) fewer general and acute beds across England, but occupancy never exceeded 72%. The closest to full occupancy of general and acute bed (surge) capacity that any trust in England reached was 99.8% . For beds compatible with mechanical ventilation there were 326 trust-days (3.7%) spent above 85% of surge capacity and 154 trust-days (1.8%) spent above 92%. 23 trusts spent a cumulative 81 days at 100% saturation of their surge ventilator bed capacity (median number of days per trust=1, range: 1–17). However, only three sustainability and transformation partnerships (aggregates of geographically co-located trusts) reached 100% saturation of their mechanical ventilation beds.ConclusionsThroughout the first wave of the pandemic, an adequate supply of all bed types existed at a national level. However, due to an unequal distribution of bed utilisation, many trusts spent a significant period operating above ‘safe-occupancy’ thresholds despite substantial capacity in geographically co-located trusts, a key operational issue to address in preparing for future waves.
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Bhattarai, Subash, Merina Gyawali, Khus Raj Dewan e Gaurav Shrestha. "Demographic and Clinical Profile in Patients with Liver Cirrhosis in a Tertiary Care Hospital in Central Nepal". Journal of Nepal Medical Association 56, n.º 208 (31 de dezembro de 2017): 401–6. http://dx.doi.org/10.31729/jnma.3362.
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Introduction: Liver cirrhosis is an important health problem worldwide and is a common disease in Nepal. The profile of cirrhosis may vary due to different factors. This study was undertaken to see the demographic and clinical profiles of patients with cirrhosis of liver attending a tertiary care hospital in Central Nepal.
Methods: Six hundred patients with clinical features, laboratory and sonological findings suggestive of chronic liver dysfunction and endoscopic evidence of portal hypertension were included in the study. Their demographic and clinical profile, endoscopic findings, outcomes during hospitalization were studied. Ethical approval was taken from Institutional Review Committee of College of Medical Sciences. SPSS 20 was used for statistical analysis.
Results: The mean age of subjects was 54±11.84 years with 435 males (72.5%) and 165 (27.5%) females. Majority of 203 (33.8%) patients were from Mongol ethnicity followed by 127 (21.2%) Khas. Two hundred and twenty (36.6%) were farmers followed by 169 (28.2%) retired personnel. A total of 338 (56.4 %) patients were from rural areas. The commonest aetiology of cirrhosis was chronic alcohol consumption and seen in 552 (92%) patients. Abdominal distension was commonest presenting sign and observed in 561 (93.5%) patients. Ascites seen in 555 (92.5%) patients was the commonest complication followed by UGI bleed in 326(54.3%) patients. Gastro-oesophageal varices observed in 345 (57.5%) patients, was the most common endoscopic finding followed by portal gastropathy, peptic ulcer and erosive mucosal diseases. In patient mortality was noted in 92 (15.3 %) patients.
Conclusions: This study highlights the burden of cirrhosis, usually caused by chronic alcohol consumption in Central Nepal. Majority of subjects were male, middle aged, farmers, from rural areas and predominantly observed in some ethnicity like Mongols. Cirrhotic patients usually present late with varied complications and have high mortality.
Keywords: cirrhosis of liver; complications; endoscopy.
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Back, Kyoungwhan, Lee Hyoung Yool e Hwang Ok Jin. "Functional characterization of tobacco (Nicotiana benthamiana) serotonin N-acetyltransferases (NbSNAT1 and NbSNAT2)". Melatonin Research 4, n.º 4 (31 de dezembro de 2021): 507–21. http://dx.doi.org/10.32794/mr112500109.
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Nicotiana benthamiana (tobacco) is an important dicotyledonous model plant; however, no serotonin N-acetyltransferases (SNATs) have been characterized in tobacco. In this study, we identified, cloned, and characterized the enzyme kinetics of two SNAT genes from N. benthamiana, NbSNAT1 and NbSNAT2. The substrate affinity (Km) and maximum reaction rate (Vmax) for NbSNAT1 were 579 µM and 136 pkat/mg protein for serotonin, and 945 µM and 298 pkat/mg protein for 5-methoxytryptamine, respectively. Similarly, the Km and Vmax values for NbSNAT2 were 326 µM and 26 pkat/mg protein for serotonin, and 872 µM and 92 pkat/mg protein for 5-methoxytryptamine, respectively. Moreover, we found that NbSNAT1 and NbSNAT2 localized to chloroplasts, similar to SNAT proteins from other plant species. The activities of the NbSNAT proteins were not affected by melatonin feedback inhibition in vitro. Finally, transgenic tobacco plants overexpressing either NbSNAT1 or NbSNAT2 did not exhibit increased melatonin levels, possibly due to the expression of catabolic enzymes. Generating transgenic tobacco plants with downregulated NbSNAT expression would provide further insight into the functional role of melatonin in tobacco plants.
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Sudaryono, Prihastuti e Andy Wijanarko. "Land Suitability for Developing Soybean Crops in Bumi Nabung and Rumbia Districts, Central Lampung". Journal of Tropical Soils 16, n.º 1 (2 de julho de 2013): 85–92. http://dx.doi.org/10.5400/jts.2011.v16i1.85-92.
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Bumi Nabung district consists of 6 villages with a total area of 7,810 ha which are divided into 251 ha of rain fed rice lands, 4,908 ha of dry land, 1,317 ha of lowland, 1,158 ha of yards and 176 ha of others. Rumbia district consists of 14 villages which has a total area of 22,696 ha of land consisting of 2,728 ha of yards, 17,358 ha of dry land, 326 rainfed paddy field, 839 ha of swamp land, 1,470 ha of lowland and 4,232 ha of others. Bumi Nabung and Rumbia districts have a low soil fertility potential that is reflected by the lowof soil pH, CEC, total N, available P, and high level of exchangeable Al and Al saturation. The results assessment based on the physical and chemical characteristics showed that Bumi Nabung district have 5 villages on suitable class S-2 (North Bumi Nabung, East Bumi Nabung, Bumi Nabung Ilir, South Bumi Nabung, and Sri Kencono) and one village New Bumi Nabung has less suitable class S-3. In the Rumbia District, there were 14 villages belonged to suitable class (S-2), namely Reno Basuki, Rekso Binangun, Teluk Dalam Ilir, Rukti Basuki, Restu Baru, Restu Buana, Bina Karya Buana, Bina Karya Putra, Bina Karya Jaya, Bina Karya Utama, Bina Karya Sakti, Joharan, Rantau Jaya Ilir and Rantau Jaya Baru. Bumi Nabung and Rumbia districts have the potential fertility and land suitability for extensification and development of soybean crops. The main technology components to support this program are the use of ameliorant (dolomite and zeolite), the application of organic fertilizers (manure and compost) and inorganic fertilizers (NPK).Keywords: Acid soil, central Lampung, land suitability, soil fertility, soybeans
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Festic, Noemi, Moritz Büchi e Michael Latzer. "It’s still a thing: digital inequalities and their evolution in the information society". Studies in Communication and Media 10, n.º 3 (2021): 326–61. http://dx.doi.org/10.5771/2192-4007-2021-3-326.
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Internet diffusion has prompted research into differences in internet access, use and consequences. Exploiting the full potential of the ongoing digital transformation in all spheres of life-a proclaimed goal of governments and international organizations-requires ensuring equal opportunities and supporting disadvantaged individuals in their internet use. Using representative, population-level survey data from Switzerland spanning nearly a decade (2011-2019; Ntotal = 5,581), multiple multivariate regression analyses tested the effects of demographic and internet-use related variables on access (general and mobile), on internet skills and on different types of use (information, entertainment, commercial transactions and communication). Results indicated that despite high access rates (92% in 2019), considerable usage inequalities persist in the Swiss information society: in particular, we found an increasing marginalization of older individuals regarding the adoption of the internet and revealed the importance of internet skills, experience and mobile internet use for adopting differentiated types of use. The extreme differences between the highly connected majority and an increasingly marginalized minority raise concerns about the latter group’s opportunities for personal, social and economic benefits in an information society. This study provides unique results on current digital inequalities and their evolution which are crucial for assessing the success, suitability and legitimacy of digitization policies.
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Massalha, Emma Samah, e Lenka Zvirinska. "Enzalutamide: Do treatment modifications allow drug continuation without losing disease control?" Journal of Clinical Oncology 36, n.º 6_suppl (20 de fevereiro de 2018): 326. http://dx.doi.org/10.1200/jco.2018.36.6_suppl.326.
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326 Background: Enzalutamide improves progression free and overall survival in men with metastatic prostate cancer (Beer T, et al. 2014; Cabot R, et al. 2012). Grade 3 adverse events occur in up to 48% (Beer T, et al. 2014; Cabot R, et al. 2012). and lead to treatment discontinuation in up to 8% (Beer T, et al. 2014; Cabot R, et al. 2012). The purpose of this retrospective analysis is to determine whether treatment modification (TM) with dose reduction (DR), treatment break (TB) or both, still allow control of prostate cancer in men who may have otherwise stopped treatment due to intolerable side effects. Methods: All patients in North Wales, UK, who commenced enzalutamide for metastatic prostate cancer in 2016 were eligible. Data was collected and recorded from electronic notes and prescriptions. Results: 66 men aged 61 to 92 (median 77) commenced treatment with enzalutamide in 2016. 17% performance status (PS) 0, 51% PS 2, 3% PS 3. Treatment has been discontinued in 80%. Adverse events (AEs) led to discontinuation in 25% cases including 2 deaths. The most common AE was fatigue in 37%. 11 patients (17%) had TM due to AEs. Mean treatment duration was 9.6 months (range 1 to 19.2 months), without TM 8.9 months, with TM, 12.8 months. Men with PS 2 were more likely to require TM or discontinuation (D) due to AEs (29% each) compared to PS 1 (24% TM, 21% D) or PS 0 (1% TM, 27% D). TBs lasted between 2 weeks and 7 months. PSA rose during that time but quality of life improved and PSA responded once treatment was recommenced. After a TB, enzalutamide was continued for 2 to 11 months (median 5.9 months). DR did not adversely affected PSA in 6 of 7 cases and improved quality of life in 2 cases. Patients continued enzalutamide 2-12 months (median 5.9 months) after dose reduction, including 4 still on treatment. Conclusions: This shows that both treatment breaks and dose reductions can improve quality of life whilst not adversely affecting outcome. However, the numbers are small and this needs to be confirmed in a prospective study. Those with lower PS are more likely to require modification.
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Li, Mingze, Shuting Peng e Liwen Liu. "How Do Team Cooperative Goals Influence Thriving at Work: The Mediating Role of Team Time Consensus". International Journal of Environmental Research and Public Health 19, n.º 9 (29 de abril de 2022): 5431. http://dx.doi.org/10.3390/ijerph19095431.
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Thriving at work is beneficial to the physical and mental health of individuals, promotes the innovation and development of organizations, and is a shield against job burnout. However, the current research on the antecedents of thriving at work lacks the exploration of team characteristics. This study introduces team temporal leadership as a moderating variable and team time consensus as a mediating variable to explore the relationship between team cooperative goals and thriving at work. Based on the analysis of 326 data from 92 teams, the results showed that: (1) Team cooperative goals have a significant positive impact on team time consensus, and team time consensus has a significant positive impact on team thriving at work; (2) Team time consensus mediates the relationship between team cooperative goals and team thriving at work; and (3) Team temporal leadership not only moderated the relationship between team cooperative goals and team time consensus, but also moderated the indirect effect of team cooperative goals on team thriving at work through team time consensus. This study enriches the research on the triggering mechanism of thriving at work to some extent and provides enlightenment for organizations to stimulate the state of thriving at work.
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Arakawa, Hiroshi, Akinori Nagano, Dean C. Hay e Hiroaki Kanehisa. "The Effects of Ankle Restriction on the Multijoint Coordination of Vertical Jumping". Journal of Applied Biomechanics 29, n.º 4 (agosto de 2013): 468–73. http://dx.doi.org/10.1123/jab.29.4.468.
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The current study aimed to investigate the effect of ankle restriction on the coordination of vertical jumping and discuss the influence of energy transfer through m. gastrocnemius on the multijoint movement. Eight participants performed two types of vertical jumps: a normal squat jump, and a squat jump with restricted ankle joint movement. Mechanical outputs were calculated using an inverse dynamics analysis. Custom-made shoes were used to restrict plantar flexion, resulting in significantly (P < .001) reduced maximum power and work at the ankle joint to below 2% and 3%, while maintaining natural range of motion at the hip and knee. Based on the comparison between the two types of jumps, we determined that the ankle restriction increased (P < .001) the power (827 ± 346 W vs. 1276 ± 326 W) and work (92 ± 34 J vs. 144 ± 36 J) at the knee joint. A large part of the enhanced output at the knee is assumed to be due to ankle restriction, which results in the nullification of energy transport via m. gastrocnemius; that is, reduced contribution of the energy transfer with ankle restriction appeared as augmentation at the knee joint.
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Llosa, Augusto E., Zeina Ghantous, Renato Souza, Fabio Forgione, Pierre Bastin, Alison Jones, Annick Antierens, Andrei Slavuckij e Rebecca F. Grais. "Mental disorders, disability and treatment gap in a protracted refugee setting". British Journal of Psychiatry 204, n.º 3 (março de 2014): 208–13. http://dx.doi.org/10.1192/bjp.bp.112.120535.
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BackgroundStudies have shown high levels of distress and mental disorder among people living in refugee camps, yet none has confirmed diagnosis through clinical reappraisal.AimsTo estimate the prevalence of mental disorders, related disability and treatment gap in adult refugees living in the Burj el-Barajneh camp.MethodRandomly selected participants were screened by household representative (n = 748) and individual (n = 315) interviews; clinical reappraisal was performed on a subset (n = 194) of 326 selected participants. Weighted prevalence estimates and 95% confidence intervals were calculated.ResultsThe prevalence of current mental disorders was 19.4% (95% CI 12.6–26.2); depression was the most common diagnosis (8.3%, 95% CI 4.4–12.2) and multiple diagnoses were common (42%) among the 88 persons with mental disorder. Lifetime prevalence of psychosis was 3.3% (95% CI 1.0–5.5). Mental disorders were associated with moderate to severe dysfunction (odds ratio = 8.8, 95% CI 4.5–17.4). The treatment gap was 96% (95% CI 92–100).ConclusionsA range of mental disorders and associated disability are common in this long-term refugee setting. Combined with an important treatment gap, findings support the current consensus-based policy to prioritise availability of mental health treatment in refugee camps, especially for the most severe and disabling conditions.
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Singh, Ajay P., Ahmed Shady, Ejiro Gbaje, Marlon Oliva, Samantha Golden Espinal, Dylan Macciola, Dyanna Soto et al. "Factors associated with survival in patients with COVID -19 admitted to a community hospital in New York City". Journal of Lung, Pulmonary & Respiratory Research 8, n.º 2 (1 de abril de 2021): 27–33. http://dx.doi.org/10.15406/jlprr.2021.08.00247.
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Introduction: COVID-19 has been associated with increased mortality in old age, hypertension and male gender. Higher prevalence of increased body mass index (BMI), mechanical ventilation and renal failure has been found in the patients admitted to our New York City community hospital; accordingly we aim to explore the association between these parameters and survival in our patients. Methods: Retrospective review of patients admitted with the COVID-19 disease March 14 to April 30 of 2020. Analysis using Cox regression models, Log rank tests and Kaplan Meier curves was done for a total of 326 patients that met our criteria. Results: The adjusted odds of death for those at least 75 years of age were higher than those within the age group of 18 to 44 years. The patients with over 92% oxygen saturation had lower adjusted odds of death than those with 88 to 92% oxygen saturation (Odds Ratio (OR)=0.2, 95% CI=0.06, 0.70), as well as lower adjusted hazard of dying (Hazard Ratio (HR)=0.4, 95% CI=0.21, 0.87). Intubation was associated with a higher adjusted odds ratio (OR=57.8, 95% CI=17.74, 188.30) and adjusted hazard ratio HR=5.4 (95% CI=2.59, 11.21) for death. After controlling for age and gender, neither levels of serum D-dimer nor creatinine were found to be significantly associated with mortality The factors that comprise metabolic syndrome, i.e., elevated BMI, diabetes, hypertension, and hyperlipidemia, were found to have no significant association with the outcome of death after controlling for age and sex and they also had no significant association with the time until death. Conclusions: In the study population, COVID-19 was associated with increased mortality in patients who required intubation, and in the elderly, which may be explained by changes in the immune system over time. Elevated BMI, though not statistically significant, was present in the majority of our study population, which may have contributed to the group's high mortality.
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Oliveira, Samilly, Elias Machado, Fabricio Fóla, Zumira Aparecida Carneiro e Charles Marques Lourenço. "Uso de canabidiol como terapia adjuvante em paciente com síndrome de Zellweger: relato de caso". Medicina (Ribeirão Preto) 53, n.º 3 (14 de outubro de 2020): 321–26. http://dx.doi.org/10.11606/issn.2176-7262.v53i3p321-326.
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Também denominada síndrome cerebrohepatorenal, a síndrome de Zellweger é uma doença autossômica recessiva rara, pertencente ao espectro de erros inatos do metabolismo que afetam os peroxissomos. São causados principalmente por mutações em qualquer um dos 14 genes PEX diferentes que codificam para proteínas envolvidas na montagem do peroxissoma, sendo a mais comum do PEX1. O quadro clínico geralmente é observado no período neonatal e primeira infância, incluindo alterações faciais, hipotonia profunda e ausência de reflexos neonatais, além de disfagia, disfunção hepática e convulsões. O diagnóstico é feito a partir da clínica e testes bioquímicos e confirmados pela visualização da mutação em um dos 14 genes PEX. Como não há tratamento específico, é feito tratamento sintomático. Nosso paciente masculino de 1 ano e 9 meses apresentou a hipotonia congênita como sintoma marcante, além de crises convulsivas recorrentes logo após o nascimento. Evoluiu com necessidade de gastrostomia e estagnação de marcos neuromotores. O diagnóstico foi confirmado aos seis meses, através da dosagem de ácidos graxos de cadeia longa. Crises convulsivas evoluíram de maneira refratária a diversos anticonvulsivantes e com elevada frequência diária, por isso iniciamos canabidiol (CBD-RSHO GOLD) por via enteral que reduziu significantemente as crises. Não há tratamento definitivo para esta enfermidade, sendo importante tratamento sintomático das crises convulsivas e terapias de reabilitação, nesse caso, o uso de (CBD- RSHO GOLD) provocou uma redução de 92% na frequência de crises diárias do paciente. No entanto, não é possível concluir, ainda, melhoras em outros sinais e sintomas.
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Livingtson, Katherine. "Inorganic Reactions and Methods . J. J. Zuckerman, Ed. Vol. 1, The Formation of Bonds to Hydrogen (Part 1). VCH, Deerfield Beach, FL, 1986. xxvi, 326 pp., illus. $92." Science 233, n.º 4768 (5 de setembro de 1986): 1103. http://dx.doi.org/10.1126/science.233.4768.1103.a.
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Rathore, Chaturbhuj, Malcolm K. Jeyaraj, Gopal K. Dash, Pandurang Wattamwar, Neeraj Baheti, Sankara P. Sarma e Kurupath Radhakrishnan. "Outcome after seizure recurrence on antiepileptic drug withdrawal following temporal lobectomy". Neurology 91, n.º 3 (20 de junho de 2018): e208-e216. http://dx.doi.org/10.1212/wnl.0000000000005820.
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ObjectiveTo study the long-term outcome following seizure recurrence on antiepileptic drug (AED) withdrawal after anterior temporal lobectomy for mesial temporal lobe epilepsy.MethodsWe retrospectively studied the AED profile of patients who had a minimum of 5 years of postoperative follow-up after anterior temporal lobectomy for mesial temporal lobe epilepsy. Only those patients with hippocampal sclerosis or normal MRI were included. AED withdrawal was initiated at 3 months in patients on ≥2 drugs and at 1 year for patients on a single drug.ResultsThree hundred eighty-four patients with median postoperative follow-up of 12 years (range, 7–17 years) were included. Of them, 316 patients (82.3%) were seizure-free during the terminal 1 year. AED withdrawal was attempted in 326 patients (84.9%). At last follow-up, AEDs were discontinued in 207 patients (53.9%). Seizure recurrence occurred in 92 patients (28.2%) on attempted withdrawal. After a median postrecurrence follow-up of 7 years, 79 (86%) of them were seizure-free during the terminal 2 years. AEDs could be stopped in 17 patients (18.5%) and doses were reduced in another 57 patients (62%). Patients with febrile seizures, normal postoperative EEG at 1 year, and duration of epilepsy of <20 years (FND20 score) had 17% risk of seizure recurrence on attempted AED withdrawal. We also formulated a score to predict the chances of AED freedom for the whole cohort.ConclusionPatients with seizure recurrence on AED withdrawal have good outcome with 86% becoming seizure-free and 18% becoming drug-free after initial recurrence. A FND20 score helps in predicting recurrence on AED withdrawal.
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Andrikopoulou, Angeliki, Almog Shalit, Eleni Zografos, Konstantinos Koutsoukos, Anna-Maria Korakiti, Michalis Liontos, Meletios-Athanasios Dimopoulos e Flora Zagouri. "MicroRNAs as Potential Predictors of Response to CDK4/6 Inhibitor Treatment". Cancers 13, n.º 16 (16 de agosto de 2021): 4114. http://dx.doi.org/10.3390/cancers13164114.
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Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors have emerged as novel treatment options in the management of advanced or metastatic breast cancer. MicroRNAs are endogenous non-coding 19–22-nucleotide-long RNAs that regulate gene expression in development and tumorigenesis. Herein, we systematically review all microRNAs associated with response to CDK4/6 inhibitors in solid tumors and hematological malignancies. Eligible articles were identified by a search of the MEDLINE and ClinicalTrials.gov databases for the period up to1 January 2021; the algorithm consisted of a predefined combination of the words “microRNAs”, “cancer” and “CDK 4/6 inhibitors”. Overall, 15 studies were retrieved. Six microRNAs (miR-126, miR-326, miR3613-3p, miR-29b-3p, miR-497 and miR-17-92) were associated with sensitivity to CDK4/6 inhibitors. Conversely, six microRNAs (miR-193b, miR-432-5p, miR-200a, miR-223, Let-7a and miR-21) conferred resistance to treatment with CDK4/6 inhibitors. An additional number of microRNAs (miR-124a, miR9, miR200b and miR-106b) were shown to mediate cellular response to CDK4/6 inhibitors without affecting sensitivity to treatment. Collectively, our review provides evidence that microRNAs could serve as predictive biomarkers for treatment with CDK4/6 inhibitors. Moreover, microRNA-targeted therapy could potentially maximize sensitivity to CDK4/6 inhibition.
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Tessema, Roba Argaw, Károly Nagy e Balázs Ádám. "Pesticide Use, Perceived Health Risks and Management in Ethiopia and in Hungary: A Comparative Analysis". International Journal of Environmental Research and Public Health 18, n.º 19 (3 de outubro de 2021): 10431. http://dx.doi.org/10.3390/ijerph181910431.
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Pesticides play a very important role for ensuring food security and economic growth but their use can cause harmful effects to human health and to the environment. The study aimed to investigate the level of knowledge, health risk perceptions, and experiences on the practice of pesticide use and management among extension officers in Ethiopia and plant doctors in Hungary. A questionnaire survey among 326 officers was conducted in the two study areas and data were analyzed by ordinal logistic regression. According to the findings, Hungarian officers had much better knowledge of pesticide products (92%), and less frequently experienced pesticide poisoning among applicators (7%) than the Ethiopians (66% and 41%, respectively). Hungarian officers perceived less health risk of pesticide use (AOR = 0.46, 95%, Cl: 0.27–0.80), were ten times more likely to deem the pesticide management system effective (AOR = 10.23, 95%, Cl: 5.68–18.46) and were nine times more likely to report that applicators used personal protective equipment (AOR = 8.95, 95%, Cl: 4.94–16.28). A significant proportion of officers from both countries reported inappropriate methods of pesticide residue disposal. These observations point out that the situation of pesticide use and knowledge and management of pesticide products is definitely better in Hungary; nevertheless, the issue continues to need more attention in both settings.
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Skinner, Christopher W. "The Temporal Mechanics of the Fourth Gospel: A Theory of Hermeneutical Relativity in the Gospel of John. By Douglas Estes. Biblical Interpretation, 92. Leiden: Brill, 2008. Pp. vii + 326. Cloth, $172.00." Religious Studies Review 39, n.º 4 (dezembro de 2013): 267. http://dx.doi.org/10.1111/rsr.12084_14.
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Sempere Robles, L., B. Purificación, J. Cameo, A. Gutiérrez, R. Laveda, M. García, M. Aguas et al. "P247 Sex-related differences in clinical diagnosis of inflammatory bowel disease". Journal of Crohn's and Colitis 14, Supplement_1 (janeiro de 2020): S271—S272. http://dx.doi.org/10.1093/ecco-jcc/jjz203.376.
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Abstract Background There is a lack of knowledge of the differences between women and men in clinical behaviour at the onset of inflammatory bowel disease (IBD). We hypothesise a potential diagnostic delay in women in IBD. The aims of this study were: (1) to evaluate the differences in diagnostic effort between women and men with IBD and (2) to assess the sex differences in IBD diagnosis and its impact on the gender roles, the quality of life and the emotional sphere. Methods We performed a prospective multicentre observational study in adults with a new diagnosis of IBD. The diagnostic process of IBD was reconstructed with semistructured interviews and electronic clinical records. Time to diagnostic resolution after the onset of symptoms and misdiagnosis of IBD in the different levels of the healthcare system were analysed. Patient delay was defined as the period from symptom recognition to first medical consultation. An additional interview was conducted to assess differences between women and men in the influence of IBD in gender roles (directed questions), quality of life (IBDQ-32), anxiety and depression (Hospital Anxiety and Depression Scale) and stress (Disease-Related Stress Appreciation Scale). Results 121 patients were included (44.6% CD, 53.7% UC, 1.7% IBD-U), (43.8% women 56.2% men) (median age 43 years, 29.5–55). Time to diagnostic resolution was higher in women compared with men, 214 days (93–452) vs. 90 days (40–183) p = 0.001. These differences were more evident in CD 326 days (94–627) / 67 days (28–182) p = 0.007, than in CU 174 days (92–350) / 92 days (47–184) p = 0.078. There were no significant sex differences in patient delay. Misdiagnosis of IBD was found to be 71.7% for women and 48.5% for men (p = 0.010). Data from Table 1 and Table 2 show the sex differences in the ‘influence’ of IBD in a sample of gender roles evaluated, the quality of life and the emotional sphere. Conclusion Our results demonstrate that women with IBD show a higher diagnostic delay and misdiagnosis compared with men. This delay is more evident in CD. Moreover, there is a higher impact of IBD diagnosis in women on the gender roles, the quality of life and the emotional sphere.
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Belldegrun, A. S., S. Riggs, N. Zomorodian, A. J. Pantuck, T. Klatte e F. F. Kabbinavar. "Personalized surveillance and prognostication of patients undergoing kidney cancer surgery: The 15-year UCLA experience". Journal of Clinical Oncology 25, n.º 18_suppl (20 de junho de 2007): 5045. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.5045.
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5045 Background: Renal cell carcinoma (RCC) is a heterogeneous disease with varying biology, clinical manifestations, and outcome. An evolving understanding of prognostic factors for patients is leading toward individualized surveillance as well as treatment. We reviewed our large single center experience trying to maximize prognostication and surveillance for each patient. Methods: The charts of 1,825 patients with renal masses from 1989–2006 were reviewed and 263 variables/patient were recorded. 1,492 underwent partial or radical nephrectomy with the final histology being RCC. Statistical analysis was performed via Cox regression and concordance models. This enabled us to investigate the Surveillance & Prognosis University of California Integrated Staging System (S&P-UISS), a 3-tiered group system for based on low (LR), intermediate (IR) and high risk (HR) categorization separately for both non-metastatic (NM) and metastatic (M) patients, and to compare its prognostic accuracy with the current TNM classification. Results: Of all patients analyzed 66% were male. A Fuhrman grade of 1, 2, 3 and 4 was assigned to 179 (12.3%), 675 (46.5%), 485 (33.4%), and 114 patients (7.8%), respectively. ECOG performance status was 0, 1, 2 and 3 in 768 (52.1%), 652 (44.3%), 51 (3.5%), and 2 (0.1%), respectively. The disease-specific survival (%) for NM LR (n=326, 22%), IR (n=464, 32%), and HR (n=121, 8%) patients was, respectively, 97, 81, 62 at 5 years; 92, 46, 41 at 10 years; 92, 45, 20 at 15 years. For M LR (n=78, 5%), IR (n=406, 28%) and HR (n=58, 4%) survival was 41, 18, 8 at 5 years; 31, 7, 0 at 10 years; and 31, 0, 0 at 15 years, respectively. Based on concordance statistics, S&P-UISS predicted disease-specific survival better than the 2002 TNM system. Conclusions: The S&P-UISS system is a highly reliable and reproducible predictor of mortality following surgical therapy for localized and metastatic RCC. Surveillance and personal treatments should be individualized for a particular patient based on risk group categorization following surgery for their primary tumor. Accurate prognostication allows personal tailoring for treatments as well as allocation into clinical trials. No significant financial relationships to disclose.
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Kolrud, Helge Jakob. "Mangelsbeføyelsene i NL 92". Jussens Venner 34, n.º 05-06 (1 de novembro de 1999): 292–304. http://dx.doi.org/10.18261/issn1504-3126-1999-05-06-03.
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Lampropoulos, D., H. Klaas e D. Spini. "I am not autonomous enough! The role of autonomy beliefs in the relation between social stigma and recovery". European Psychiatry 65, S1 (junho de 2022): S594. http://dx.doi.org/10.1192/j.eurpsy.2022.1521.
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Introduction It has been suggested that liberal values such as lack of autonomy and burden discourses shape the public’s relation toward people with health problems. However, previous research on the role of such values on one’s recovery and well-being is scarce. Objectives We investigated whether perceived autonomy mediates the impact of stigma and negative social experiences on life satisfaction and recovery. Methods Our sample, drawn from a subsample of the Swiss Household Panel survey, consisted of 326 individuals reporting a mental health problem (50.3% women, Mage = 50.7, SD = 13) and 354 individuals reporting a physical health issue (49.7% women, Mage = 53.6, SD = 14.7). We tested a model where perceived autonomy, measured with four items drawn from the Acceptance of Illness Scale (AIS), mediates the impact of experienced stigma and negative social experiences on health satisfaction and self-reported recovery. Results Our analysis of direct and indirect paths confirmed our hypothesis. Our model showed a good fit to the data for persons with a mental health problem (CFI = .984; RMSEA = .038) and an adequate fit for persons with a physical health problem (CFI = .92; RMSEA = .080). Conclusions Our results provide empirical evidence for the potentially self-stigmatizing role of the autonomy ideal for people with health problems and invite for the development of further research and practice regarding this role. Disclosure No significant relationships.
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Reichard, Chad A., Evan Kovac, Jay P. Ciezki, Rahul D. Tendulkar, Eric A. Klein e Andrew J. Stephenson. "Biochemical failure after treatment for localized prostate cancer: Does original therapeutic modality affect long-term survival?" Journal of Clinical Oncology 33, n.º 7_suppl (1 de março de 2015): 65. http://dx.doi.org/10.1200/jco.2015.33.7_suppl.65.
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65 Background: Mortality among men with biochemical failure (BF) after treatment is variable. We examined the long-term survival of men with BF to determine if differences exist, depending on original treatment modality. Methods: Between 1995 and 2008, 6,084 patients underwent treatment for clinically localized prostate cancer at our institution (4,276 underwent radical prostatectomy (RP); 1,808 underwent EBRT). Clinical information and follow up data was obtained from prospectively maintained databases. Survival was assessed using log rank test. Results: 526 (12%) patients had BF defined by PSA > 0.4 after RP. 326 (18%) patients had BF after EBRT, defined as PSA nadir +2. 197 (60%) of EBRT patients received ADT as neoadjuvant/concurrent/adjuvant therapy. Median overall survival was 154 months (95%CI 148-157) versus 129 months (95%CI 123-135) for RP and EBRT respectively (p<.0001). Median prostate cancer specific survival was 125 months (95%CI 93-148) versus 107 months (95%CI 92-123) for RP and EBRT respectively (p=0.17). There was no difference in prostate cancer specific survival between treatments among patients in D’Amico intermediate and high risk groups. Conclusions: In patients with biochemical recurrence after definitive treatment, patients treated with RP have improved overall survival compared to patients treated with EBRT. However, there is no difference among treatment groups in prostate cancer specific survival.
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Giri, Shailendra, Poisson Laila, Jaspreet Singh, Hamid Suhail, Mandar Deshpande, Indrani Datta, Moses Rodriguez, Ramandeep Rattan e Ashutosh Mangalam. "Profile of circulatory metabolites in chronic mouse model of multiple sclerosis using untargeted global metabolomics (THER3P.883)". Journal of Immunology 192, n.º 1_Supplement (1 de maio de 2014): 136.9. http://dx.doi.org/10.4049/jimmunol.192.supp.136.9.
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Abstract Multiple sclerosis is a chronic inflammatory and demyelinating disease of the CNS. Although, MS is well characterized in terms of the role played by immune cells, cytokines and CNS pathology, nothing is known about the metabolic alterations that occur during the disease process in circulation. Here, we profiled the plasma metabolites of B6 with EAE, a known model of chronic MS using untargeted global metabolomics. Using a combination of high-throughput liquid-and-gas chromatography with mass spectrometry, a total of 326 metabolites were identified, with significant changes observed in 105 metabolites (13 up- and 92 down-regulated), that mapped to lipid and amino acid pathways, followed by the peptide, xenobiotic, carbohydrate, nucleotide and energy pathways (p<0.05). To understand the functional role of these alterations, the KEGG metabolic library was analyzed using Metaboanalyst. The top nine most significant pathways in terms of GlobeTest p-value and impact are 1) fatty acid biosynthesis, 2) lysine degradation, 3) histidine metabolism, 4) beta-alanine metabolism, 5) pentose phosphate pathway, 6) arachidonic acid metabolism, 7) linoleic acid, 8) D-arginine and ornithine. Overall, these metabolic changes could be exploited as biomarkers for EAE/MS disease and to design new treatment paradigms where metabolic interventions could be combined with present and experimental therapeutics to achieve better treatment.
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Bawden, C. R. "S. Ju. Nekljudov and Z. Tömörceren: Mongolische Erzählungenüber Geser: neue Aufzeichnunge. Aus dem Russischen übersetzt von Jörg Bäcker. (Asiatische Forschungen, Bd. 92.) vii, 326 pp., l plate. Wiesbaden: Otto Harrassowitz, 1985. DM 124." Bulletin of the School of Oriental and African Studies 50, n.º 2 (junho de 1987): 397–98. http://dx.doi.org/10.1017/s0041977x00049491.
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Terbeck, Sylvia, Guy Kahane, Sarah McTavish, Julian Savulescu, Neil Levy, Miles Hewstone e Philip Cowen. "Corrigendum to ‘Beta adrenergic blockade reduces utilitarian judgement’ [Biol. Psychol. 92 (2013) 323–328]". Biological Psychology 103 (dezembro de 2014): 370. http://dx.doi.org/10.1016/j.biopsycho.2014.11.007.
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Kuchmenko, Kuchmenko E. M. "System approach and "clash of civilizations" in international relationship – historiosophical review". Literature and Culture of Polissya 92, n.º 10i (2018): 326–33. http://dx.doi.org/10.31654/2520-6966-2018-10i-92-326-333.
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Witkoś, Joanna, Piotr Wróbel e Barbara Błońska-Fajfrowska. "Stress urinary incontinence in women as a medical, social, psychological and economic problem – assessing the extent of knowledge of students graduating in medical fields". Rehabilitacja Medyczna 21, n.º 1 (3 de fevereiro de 2017): 12–20. http://dx.doi.org/10.5604/01.3001.0009.5500.
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Stress urinary incontinence occurs when there is an increase in pressure inside the abdomen accompanied by involuntary leakage of urine associated with coughing, sneezing, laughing or demanding physical labour. It is a serious condition that isolates women from society, prevents efficient functioning, limits social contacts and forces a change in lifestyle. The fear of leakage of urine and odour arouses embarrassment, adversely affecting the psyche - leading to decreased self-esteem, neurosis and depression. In addition, in the absence of appropriate hygiene measures, or the lack of financial resources to acquire them, incontinence can be a factor excluding women from normal life. The aim of this study was to assess the extent of knowledge of students graduating in medical fields on stress urinary incontinence in women as a medical, social, psychological and economic problem. The study involved 1,581 students during their final year of medical studies, studying at various universities. The study involved 1,255 women and 326 men. We created a questionnaire which was verified by the CEM - Institute for Market Research and Public Opinion in Krakow. The largest percentage of respondents (95%) in all groups believes that stress urinary incontinence is primarily a medical problem, approx. 92% of respondents also regarded it as a psychological problem. It was shown that stress urinary incontinence in women was found to be a medical, social, psychological and economical problem by more than half of the students of medical, obstetric and nursing fields.
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Estrada, Jorge Eduardo Chang, Keuri Eleutério Rodrigues, Anderson Maciel, Cahy Manoel Bannwart, Wictória Farias Dias, Moisés Hamoy, Russolina Benedeta Zingali et al. "BmooMPα-I, a Metalloproteinase Isolated from Bothrops moojeni Venom, Reduces Blood Pressure, Reverses Left Ventricular Remodeling and Improves Cardiac Electrical Conduction in Rats with Renovascular Hypertension". Toxins 14, n.º 11 (5 de novembro de 2022): 766. http://dx.doi.org/10.3390/toxins14110766.
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BmooMPα-I has kininogenase activity, cleaving kininogen releasing bradykinin and can hydrolyze angiotensin I at post-proline and aspartic acid positions, generating an inactive peptide. We evaluated the antihypertensive activity of BmooMPα-I in a model of two-kidney, one-clip (2K1C). Wistar rats were divided into groups: Sham, who underwent sham surgery, and 2K1C, who suffered stenosis of the right renal artery. In the second week of hypertension, we started treatment (Vehicle, BmooMPα-I and Losartan) for two weeks. We performed an electrocardiogram and blood and heart collection in the fourth week of hypertension. The 2K1C BmooMPα-I showed a reduction in blood pressure (systolic pressure: 131 ± 2 mmHg; diastolic pressure: 84 ± 2 mmHg versus 174 ± 3 mmHg; 97 ± 4 mmHg, 2K1C Vehicle, p < 0.05), improvement in electrocardiographic parameters (Heart Rate: 297 ± 4 bpm; QRS: 42 ± 0.1 ms; QT: 92 ± 1 ms versus 332 ± 6 bpm; 48 ± 0.2 ms; 122 ± 1 ms, 2K1C Vehicle, p < 0.05), without changing the hematological profile (platelets: 758 ± 67; leukocytes: 3980 ± 326 versus 758 ± 75; 4400 ± 800, 2K1C Vehicle, p > 0.05), with reversal of hypertrophy (left ventricular area: 12.1 ± 0.3; left ventricle wall thickness: 2.5 ± 0.2; septum wall thickness: 2.3 ± 0.06 versus 10.5 ± 0.3; 2.7 ± 0.2; 2.5 ± 0.04, 2K1C Vehicle, p < 0.05) and fibrosis (3.9 ± 0.2 versus 7.4 ± 0.7, 2K1C Vehicle, p < 0.05). We concluded that BmooMPα-I improved blood pressure levels and cardiac remodeling, having a cardioprotective effect.
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Rodriguez Salas, Nuria, Jesus Miranda, Lorena Ostios, Mario Muñoz, Alberto Borobia, Gema Gordo, Jair Tenorio, Hoi Tong, Maria Teresa García Morales e Jose Carlos Martinez Avila. "KRAS/NRAS/BRAF genotyping in patients with mestastatic colorectal cancer." Journal of Clinical Oncology 36, n.º 4_suppl (1 de fevereiro de 2018): 718. http://dx.doi.org/10.1200/jco.2018.36.4_suppl.718.
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718 Background: mCRC is the 2º cause of death in the world. Development of targeted therapies has increased the survival. The efficacy of these drugs (such Bevacizumab and monoclonal antibodies against EGFR) depends on the use of genetic biomarkers such as KRAS and NRAS. The BRAF status acts as prognostic factor. The objective of this study was to perform a mutational analysis of KRAS/NRAS/BRAF in a cohort of 326 Spanish patients, and correlate the findings with clinical factors. Methods: We analyzed KRAS by chip-array analysis (Infiniti System, USA), NRAS using pyrosequencing on a Pyromark Q96MD instrument (Qiagen, USA) and BRAF mutations (in 80 of these samples) by means of Infiniti System (AutoGenomics, USA). Results: KRAS mutations 129/326 patients had KRAS mutation (31.2% in codon 12 and 6.7% in codon 13). The median age was 68.9, 55% male, 66.4% had left-sided tumor, 83% histologically grade 2 tumor. The pattern of spread was liver (51.1%), lung (33.3%) and peritoneum (11.6%). There were 6 types of mutation in codon 12 (p.Gly12Asp, p.Gly12Cys, p.Gly12Val, p.Gly12Arg, p.Gly12Ser, p.Gly12Ala) and 1 type in codon 13 (p.Gly13Asp). We apply a logistic model (age&sex corrected) to location, and we found association between KRAS wild type and left location, OR 1.73 [CI:1.03-2.9] p = 0.035 NRAS mutations: 13 patients had NRAS mutation (3.98%), 8 male, 92% had left-sided, 46% liver metastasis and 53.9% lung metastasis. Type of NRAS mutation: 1.6% in exon 2 (1.2% in codon 12 and 0.4% in codon 13) and 1.8% in exon 3 (0.2% in codon 59 and 1.6% in codon 61). In exon 2 we found 2 types of changes, 1 in codon 12 (p.Gly12Asp) and 1 in codon 13 (p.Gly13Arg). In exon 3 we found 5 types of changes, 1 in codon 59 (p.Ala59Thr) and 4 in codon 61 (p.Gln61Glu; p.Gln61Leu; p.Gln61Arg; p.Gln61His). BRAF mutation: 9/80 patients harboured mutations, all of them at the residue V600E. Conclusions: In our cohort 39.5% had mutations in KRAS, 3.98% in NRAS and 11% in BRAF. KRAS mutation is associated to right-sided location.
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Sylvia, Terbeck, Kahane Guy, McTavish Sarah, Savulescu Julian, Levy Neil, Hewstone Miles e Philip J. Cowen. "Corrigendum to “Beta adrenergic blockade reduces utilitarian judgment” [Biol. Psychol. 92 (2) (2013) 323–328]". Biological Psychology 97 (março de 2014): 67. http://dx.doi.org/10.1016/j.biopsycho.2013.12.010.
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Waheed, Shahan, Rida Jawed, Ahmed Raheem e Asad Iqbal Mian. "A Prospective Study Evaluating Gender Differences of Serious Outcomes through Difficult Airway Physiological Score (DAPS) in the Emergency Department". Critical Care Research and Practice 2024 (20 de maio de 2024): 1–8. http://dx.doi.org/10.1155/2024/4622511.
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Introduction. Gender variation in critically ill adults after resuscitation is reported in many studies. However, this variation is not well established when evaluating the physiological instability in this population. This study aimed to prospectively evaluate the gender variation in serious outcomes by the difficult airway physiological score (DAPS) among critically ill patients requiring endotracheal intubation (ETI). Methods. This is a cohort study conducted from August 2021 to December 2022 in the emergency department of Aga Khan University. The prospective validity of the difficult airway physiological score was derived using retrospective data and includes 12 variables: sex, age, time of intubation, hypotension, respiratory distress, vomiting, shock index >0.9, pH < 7.3, fever, anticipated decline, Glasgow Coma Scale (GCS) < 15, and agitation. The serious outcomes were cardiac arrest, mortality (within 1 hour after intubation in emergency), hypotension (systolic blood pressure <90 mmHg), and oxygen desaturation (SpO2 < 92%). The difference between males and females was assessed using the chi-square test, and the association of gender and serious outcomes was explored using Cox and logistic regression analysis. ROC curve analysis and area under the curve assessed score validity separately in males and females with serious outcomes. Results. We enrolled 326 patients with a mean age of 50.3 (±17.8), with 123 (33.7%) females and 203 (62.2%) males. 198 (60.7%) patients were >45 years old, of which 136 (67%) were male and 62 (50.4%) female. Cardiac arrest was observed in 56 (17.2%), with 24 (19.5%) females and 32 (15.8%) males, p value 0.348. Hypotension after intubation was observed in 132 (40.5%) patients, 56 (45.5%) females and 76 (37.4%) males, p value 0.149. Oxygen saturation (<92%) was observed in 80 (24.5%) patients, 32 (26%) females and 48 (23.6%) males, p value 0.630. In females, the DAPS of 11 had an area under the curve of 0.863 (0.74–0.91). The sensitivity of the score was 84.8%, the specificity was 71.9%, the PPV was 77.8%, and the NPV was 80.4% with an accuracy of 78.9%. In males, the DAPS score of 14 had an area under the curve of 0.892 (0.57–0.75). The sensitivity of the score was 67%, the specificity 93.8%, the PPV 92.2%, and the NPV 72.2% with an accuracy of 79.8%. Conclusions. The Difficult Airway Physiological Score (DAPS) predicts the risk of serious outcomes after intubation with high precision and reliability with different score cutoffs between the two sexes, highlighting the gender variation of a difficult airway.
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Qu, Yinsheng, Bao-Ling Adam, Yutaka Yasui, Michael D. Ward, Lisa H. Cazares, Paul F. Schellhammer, Ziding Feng, O. John Semmes e George L. Wright. "Boosted Decision Tree Analysis of Surface-enhanced Laser Desorption/Ionization Mass Spectral Serum Profiles Discriminates Prostate Cancer from Noncancer Patients". Clinical Chemistry 48, n.º 10 (1 de outubro de 2002): 1835–43. http://dx.doi.org/10.1093/clinchem/48.10.1835.
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Abstract Background: The low specificity of the prostate-specific antigen (PSA) test makes it a poor biomarker for early detection of prostate cancer (PCA). Because single biomarkers most likely will not be found that are expressed by all genetic forms of PCA, we evaluated and developed a proteomic approach for the simultaneous detection and analysis of multiple proteins for the differentiation of PCA from noncancer patients. Methods: Serum samples from 386 men [197 with PCA, 92 with benign prostatic hyperplasia (BPH), and 96 healthy individuals], randomly divided into training (n = 326) and test (n = 60) sets, were analyzed by surface-enhanced laser desorption/ionization (SELDI) mass spectrometry. The 124 peaks detected by computer analyses were analyzed in the training set by a boosting tree algorithm to develop a classifier for separating PCA from the noncancer groups. The classifier was then challenged with the test set (30 PCA samples, 15 BPH samples, 15 samples from healthy men) to determine the validity and accuracy of the classification system. Results: Two classifiers were developed. The AdaBoost classifier completely separated the PCA from the noncancer samples, achieving 100% sensitivity and specificity. The second classifier, the Boosted Decision Stump Feature Selection classifier, was easier to interpret and used only 21 (compared with 74) peaks and a combination of 21 (vs 500) base classifiers to achieve a sensitivity and specificity of 97% for the test set. Conclusions: The high sensitivity and specificity achieved in this study provides support of the potential for SELDI, coupled with a bioinformatics learning algorithm, to improve the early detection/diagnosis of PCA.
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Thanigaimani, Shivshankar, James Phie e Jonathan Golledge. "Animal models of ischemic limb ulcers: a systematic review and meta-analysis". BMJ Open Diabetes Research & Care 8, n.º 1 (agosto de 2020): e001676. http://dx.doi.org/10.1136/bmjdrc-2020-001676.
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The aims of this systematic review were to assess the clinical relevance and quality of previously published animal models of ischemic ulceration and examine the available evidence for interventions improving ulcer healing in these models. Publicly available databases were searched for original studies investigating the effect of limb ischemia on wound healing in animal models. The quality of studies was assessed using two tools based on the Animal research: Reporting of In Vivo Experiments (ARRIVE) guidelines and the clinical relevance of the models. A total of 640 wounds (ischemic=314; non-ischemic=326) were assessed in 252 animals (92 mice, 140 rats, 20 rabbits) from 7 studies. Meta-analyses showed that wound healing was consistently delayed by ischemia at all time-points examined (day-7 standard median difference (SMD) 5.36, 95% CI 3.67 to 7.05; day-14 SMD 4.50, 95% CI 2.90 to 6.10 and day-21 SMD 2.53, 95% CI 1.25 to 3.80). No significant difference in wound healing was observed between 32 diabetic and 32 non-diabetic animals with ischemic wounds. Many studies lacked methods to reduce bias, such as outcome assessors blinded to group allocation and sample size calculations and clinically relevant model characteristics, such as use of older animals and a peripheral location of the wound. Five different interventions were reported to improve wound healing in these models. The impaired wound healing associated with limb ischemia can be modeled in a variety of different animals. Improvements in study design could increase clinical relevance, reduce bias and aid the discovery of translatable therapies.
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Olsen, PD, RB Cunningham e CF Donnelly. "Avian Egg Morphometrics - Allometric Models of Egg Volume, Clutch Volume and Shape". Australian Journal of Zoology 42, n.º 3 (1994): 307. http://dx.doi.org/10.1071/zo9940307.
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This paper describes three comprehensive new models of the allometric relationships between egg volume, clutch volume and shape, and body weight. Mean egg dimensions, clutch sizes and adult body weights were obtained for 326 species, mainly of four bird types: raptors (including owls), shorebirds, frogmouths (including nightjars), and storks (including the New World vultures). These are groups in which there is a wide range of body sizes and of sexual dimorphism in body size (in direction and degree). Female body weight alone accounted for 92% of the variation in egg volume. Sexual dimorphism in body size, phylogenetic relationship, and clutch size were significant contributors to the model of egg volume; their addition increased the explained variance to over 98%. The model was curvilinear (quadratic) in form, rather than linear as assumed in previous models. Larger species laid smaller eggs than expected under a simple power function. For the fitted model, within bird types, generic groupings had parallel curvilinear slopes but differing intercepts. Between bird types, the slopes differed. Clutch volume was scaled to body weight; all the bird types had a common slope, which was curvilinear. Body weight and dimorphism accounted for 89.5% of the variation in clutch volume. For all bird types, eggs became proportionally longer in shape as body weight increased, according to a simple power law. The relevance of these relationships to hypotheses on the evolution and adaptive significance of sexual dimorphism and to the trade-off between egg size and clutch size is discussed briefly.
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Inampudi, Vineel, e Sunanda Nimmalapudi. "Efficacy of Embolization in Acquired Uterine Vascular Malformations: An Experience in Tertiary Care Centre in India". Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics 45, n.º 06 (junho de 2023): 325–32. http://dx.doi.org/10.1055/s-0043-1770092.
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Abstract Objective: To determine the efficacy of Uterine Artery Embolization in patients with bleeding acquired uterine arteriovenous malformations (AVMs). Methods: A prospective review of all patients who underwent Uterine Artery Embolization at our institution between July 2015 and April 2022 was performed. 225 patients were diagnosed with a uterine vascular malformation on doppler and corresponding MRI imaging. All patients underwent transcatheter embolization of the uterine arteries. Embolic agents in the 375 procedures included Histoacryl glue only (n = 326), polyvinyl alcohol (PVA) particles and Histoacryl glue (n = 29), PVA particles (n = 5), Gelfoam (n = 5), coils (n = 4), PVA particles and coils (n = 3), Histoacryl glue and Gelfoam (n = 2), and Histoacryl glue and coils (n = 1). Results: A total of 375 embolization procedures were performed in 225 patients. 90 patients required repeat embolization for recurrence of bleeding. The technical success rate of embolization was 100%. The clinical success rate was 92%: bleeding was controlled in 222 of 225 patients and three patients underwent a hysterectomy. 60 of the 225 patients had uneventful intrauterine pregnancies carried to term. The 210 patients who underwent successful embolization had no recurrence of bleeding at a median follow-up of 53 months (range, 5-122 months) after treatment. 15 patients were eventually lost to follow-up. One minor complication (0.4%) of non-flow-limiting dissection of the internal iliac artery occurred. Conclusion: Uterine Artery Embolization is a safe, effective, minimally invasive method to treat uterine AVMs with long-term efficacy, which can provide the preservation of fertility.
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Brito Hurtado, JE, e Zulay Bastidas Calva. "Atención recibida por traumatismo dentoalveolar en la población de la parroquia urbana El Vecino del cantón Cuenca, en el año 2019". Killkana Salud y Bienestar 7, n.º 2 (1 de maio de 2023): 39–50. http://dx.doi.org/10.26871/killcanasalud.v7i2.778.
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El presente estudio tiene por objetivo determinar las características de atención que recibieron posterior al trauma dentoalveolar, las personas de la parroquia urbana El Vecino, de la ciudad de Cuenca, en el año 2019. Para cumplir con esta finalidad, se aplicó una metodología de enfoque mixto, cualitativo y cuantitativo de diseño descriptivo, teniendo como variables de estudio los factores sociodemográficos como sexo, edad, lugar, profesional de atención y tiempo de atención. La población analizada estuvo conformada por los residentes habituales mayores de un año en las viviendas de la parroquia El Vecino; se empleó como instrumento de recolección de información un cuestionario validado, dirigido a una muestra de 326 individuos. Los resultados muestran que el 5,4% de los sujetos presentó traumatismos dentoalveolares, de los cuales se identificó una frecuencia de 12 pacientes que recibieron atención médica, la mayoría de sexo masculino, con una edad promedio de 6 a 12 años, atendidos prioritariamente por un profesional odontólogo (92%), en consultorios privados con un tiempo estimado de 24 horas a 7 días. El motivo de las lesiones fue ocasionado en el 75% de los casos por caídas, provocando traumatismos en los dientes de la arcada superior en todos los sujetos. No se identificó una asociación estadística entre el sexo, el motivo de golpe y la recepción de consulta, puesto que el valor p fue mayor a los niveles de significancia (p>0,05). Se concluye que existe una variación de la patología en los individuos con una alta frecuencia en niños, siendo más propensos a sufrir eventos que ponen en riesgo la salud bucodental.
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Brito Hurtado, Jennifer Estefany, e Magda Zulay Bastidas Calva. "Atención recibida por traumatismo dentoalveolar en la población de la parroquia urbana El Vecino del Cantón Cuenca, en el año 2019". Killkana Salud y Bienestar 5, n.º 3 (1 de setembro de 2021): 37–48. http://dx.doi.org/10.26871/killcanasalud.v5i3.645.
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El presente estudio tiene por objetivo determinar las características de atención que recibieron posterior al trauma dentoalveolar, las personas de la parroquia urbana El Vecino, de la ciudad de Cuenca, en el año 2019. Para cumplir con esta finalidad, se aplicó una metodología de enfoque mixto, cualitativo y cuantitativo de diseño descriptivo, teniendo como variables de estudio los factores sociodemográficos como sexo, edad, lugar, profesional de atención y tiempo de atención. La población analizada estuvo conformada por los residentes habituales mayores de un año en las viviendas de la parroquia El Vecino; se empleó como instrumento de recolección de información un cuestionario validado, dirigido a una muestra de 326 individuos. Los resultados muestran que el 5,4% de los sujetos presentó traumatismos dentoalveolares, de los cuales se identificó una frecuencia de 12 pacientes que recibieron atención médica, la mayoría de sexo masculino, con una edad promedio de 6 a 12 años, atendidos prioritariamente por un profesional odontólogo (92%), en consultorios privados con un tiempo estimado de 24 horas a 7 días. El motivo de las lesiones fue ocasionado en el 75% de los casos por caídas, provocando traumatismos en los dientes de la arcada superior en todos los sujetos. No se identificó una asociación estadística entre el sexo, el motivo de golpe y la recepción de consulta, puesto que el valor p fue mayor a los niveles de significancia (p>0,05). Se concluye que existe una variación de la patología en los individuos con una alta frecuencia en niños, siendo más propensos a sufrir eventos que ponen en riesgo la salud bucodental.
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Koutlouka, Maria E. "Logos et croyance religieuse chez Héraclite (Fr. 92, 93)". Kernos, n.º 4 (1 de janeiro de 1991): 259–63. http://dx.doi.org/10.4000/kernos.306.
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Faucitano, L., S. Torrey, R. Bergeron, J. R. E. del Castillo e J. J. Matte. "Effects of water supplementation with tryptophan and vitamin B6 or feeding hydrogenated fat on reducing hunger-induced drinking pre-slaughter in pigs". Canadian Journal of Animal Science 92, n.º 3 (setembro de 2012): 319–26. http://dx.doi.org/10.4141/cjas2012-008.
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Faucitano, L., Torrey, S., Matte, J. J., del Castillo, J. R. E. and Bergeron, R. 2012. Effects of water supplementation with tryptophan and vitamin B6 or feeding hydrogenated fat on reducing hunger-induced drinking pre-slaughter in pigs. Can. J. Anim. Sci. 92: 319–326. A current food safety challenge at pig slaughter plants comes with the presence of stomachs filled with liquid induced by hunger-related drinking in lairage. With the objective to reduce hunger-related excess drinking, 30 barrows were assigned to three treatments (10 pigs per treatment): (1) unsupplemented water or feed regimen (CONT), (2) L-Tryptophan (3 g L−1) and vitamin B6 (10 mg L−1) in the drinking water for 5d (TRP-B6), (3) hydrogenated fat (HF) supplemented at 10% in the diet for the last day of feeding before pre-slaughter fasting. As compared with CONT, neither TRP-B6 nor HF supplementation influenced behaviour in lairage and water intake at anytime over the pre-slaughter fasting period as reflected on stomach weight and its liquid content at slaughter (P>0.10). However, in HF-fed pigs plasma non-esterified fatty acids concentrations tended to be lower (P=0.09) while carcass yield was higher (P=0.04) than CONT pigs. It appears, therefore, that neither drinking water supplementation with TRP-B6 for 5 d nor feeding HF the last day before slaughter can be recommended strategies to limit excess water drinking prior to slaughter and liquid stomach content at slaughter. However, dietary HF supplementation the last day before slaughter may attenuate the effects of fasting on body energy reserves and improve carcass yield.
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Shar, Ghulam Shabbir, Tahir Saghir, Abdul Hakeem, Haroon Ishaq, Mukesh Kumar, Sanam Khowaja e Danish Qayyum. "IMPACT OF SMOKELESS TOBACCO USE ON DISTRIBUTION OF VESSEL INVOLVEMENT IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION". Pakistan Heart Journal 55, n.º 1 (25 de março de 2022): 47–52. http://dx.doi.org/10.47144/phj.v55i1.2180.
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Objectives: Despite widespread use of smokeless tobacco (ST) in Pakistan, a very limited empirical evidence have been reported regarding its impact on the coronary anatomy and obstructions. Therefore, this study was conducted to compare the coronary angiographic profile of smokeless tobacco (ST) users and smokers with non-tobacco users presented with acute myocardial infarction (AMI). Methodology: Consecutive patients with AMI were stratified in to four groups as tobacco non-users (G1), solo ST users (G2), both smoking and ST users (G3), and solo smokers (G4). Coronary angiographic findings regarding number of diseases vessels and infarct related artery were recorded. Results: Out of 326 patients, ST users were 28.2%(92), 6.4%(21) in conjunction with smoking and reaming 21.8%(71) without smoking. Females were 19.7%(14/71) of G2, 4.8%(1/21) of G3, 0% in G4. Young patients (≤ 40 years) were 3.4%(5/149) of G1, 9.9%(7/71) of G2, 14.1%(12/85) of G4, and 23.8%(5/21) of G3 cumulatively making 82.8%(24/29) of the young patients. Single vessel disease (SVD) and left anterior descending artery (LAD) were significantly higher among ST user as compared to non-users with distribution of 46.7% vs. 34.2% and 70.7% vs. 56.4% respectively. Conclusion: The distribution and localization of involved vessels among ST users with AMI are same as that of smokers with SCD and LAD as infarct artery as the common findings. Tendency of ST use is also high among female patients and Tobacco use in either form, smoking or smokeless, is alarmingly high (>80%) among young (≤40 years) patients with AMI.
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Misgana, Bikila, e Gudina Terefe Tucho. "Assessment of Community’s Perception Toward Single-Use Plastic Shopping Bags and Use of Alternative Bags in Jimma Town, Ethiopia". Environmental Health Insights 16 (janeiro de 2022): 117863022210850. http://dx.doi.org/10.1177/11786302221085047.
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Background: The use of plastic shopping bags increases and poses tremendous pressure on the local environment. However, little is known about its utilization among different population categories and their perception of its utilization and willingness to use other sustainable alternatives. This study aimed to assess the community’s perception toward the use of plastic shopping bags and its options in Jimma town, Ethiopia Methods: A community-based descriptive cross-sectional study design was conducted on 351 customers and retailers selected from the town’s main marketing areas. The data was collected using a structured questionnaire in a face-to-face interview and analyzed using SPSS v.21. Results: The results show that all the respondents use plastic shopping bags for different shopping services. The majority (147 (41.9%)) of the respondents said that they use 5 to 10 shopping bags, and 66 (18.8%) use more than 10 shopping bags per week. Participants responded with different reasons for the frequent use of plastic bags for shopping. Accordingly, 116 (33.0%) responded that plastic bags are cheap, 92 (26.2%) use them due to lack of alternatives, and 89 (25.4%) responded that plastic bags are light and convenient to use. However, 326 (93%) of the respondents support efforts to reduce single-use plastic bags, 284 (80.9%) support a ban on single-use plastic bags, and 319 (90%) were willing to pay for alternative shopping bags. Conclusion: Communities are aware of the environmental problems associated with the intensive use of plastic shopping bags, their wastes, and the need for alternative options. However, it will continue to pose significant environmental challenges unless low-cost and environment-friendly alternative options are available.
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Pitman-Hunt, Chaya, Kristen L. Richards, Ralph E. Delius, Henry L. Walters e Christopher W. Mastropietro. "Safety and utility of passive peritoneal drainage following Fontan palliation". Cardiology in the Young 24, n.º 3 (4 de junho de 2013): 503–9. http://dx.doi.org/10.1017/s1047951113000693.
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AbstractObjective: Placement of peritoneal drainage catheters intra-operatively has been shown to help prevent fluid overload in children recovering from surgery for two-ventricle heart disease. We aimed to determine whether this practice is also helpful in children recovering from Fontan palliation. Material and methods: A retrospective review was performed on children with single-ventricle anatomy undergoing Fontan palliation at our institution from 2007 to 2011. Variables in those with peritoneal drainage were compared with those without using t-tests, Mann–Whitney U-tests, chi-square tests, or analysis of variance for repeated measures as appropriate. Data were represented as mean with standard deviation unless otherwise noted. Results: A total of 43 children were reviewed, 21 (49%) with peritoneal drainage catheters. No complications from catheter placement occurred. The groups did not differ with regard to cardiopulmonary bypass duration, dominant ventricle, pre-operative haemodynamic data, fenestration use, and initial intensive care unit ventilation index. Central venous pressures, vasoactive medication use, and diuretic use during the first 48 hours were also not statistically different. At 48 hours, the median fluid balance was −9 (interquartile range : −50, +20) in those with peritoneal drainage and +77 cc/kg (interquartile range : +22, +96) in those without (p < 0.001), yet median duration of mechanical ventilation was 40 hours (range: 19–326) in those with peritoneal drainage and 23 hours (range: 9–92) in those without, p = 0.01. Conclusion: Patients with peritoneal drainage recovering from Fontan palliation achieved negative fluid balance as compared with those without peritoneal drainage, although this difference was associated with a longer duration of mechanical ventilation.