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Publicado: 25 de julho de 2024

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1

de Carvalho, Anibal A., e Joe F. Hennen. "New species and nomenclature inProspodium(Uropyxidaceae, Pucciniales) and the new anamorphic genusCanastain the Neotropics". Mycologia 102, n.º 5 (setembro de 2010): 1096–113. http://dx.doi.org/10.3852/09-049.

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Dunn, Danielle, Danielle Keenan-Miller, Kathy K. Isoldi, Alessandra Sarcona, Veronika Dolar e Raquel P. F. Guiné. "Measurement and Correlates of Food Selection Motivations in a United States Sample". American Journal of Health Behavior 46, n.º 2 (20 de abril de 2022): 186–96. http://dx.doi.org/10.5993/ajhb.46.2.8.

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Background: In this study, we explored the factors that motivate food choice, and evaluated the psychometric properties and demographic correlates of the Eating Motivation (EATMOT) questionnaire in adults in the United States (US). Methods: This cross-sectional survey involved 905 adults in 6 sites across the US. The EATMOT questionnaire measures participants' self-reported motivations for food selection, demographic, and anthropometric data. Analyses included exploratory and confirmatory factor analyses, correlations, Welch's t-tests, and logistic regressions. Results: We established a 3-factor model (health-related, emotional, and environmental/political motivations) as the best fit to the data (CFI = .983, RMSEA = .049, SRMR = .054). Gender differences were found within the 3 factors, as well as in the intercorrelations between factors. Higher levels of health-related motivations (B = .10, SE = .04, OR = 1.11 (95% CI: 1.03, 1.19), p = .006) were associated with increased reports of weight loss dieting, whereas higher levels of environmental/political motivations (B = -.09, SE = .04, OR = 0.91, p = .02) were associated with fewer reports of weight-loss dieting. Conclusion: An abbreviated version of the EATMOT scale is appropriate for use in a US sample and identifies 3 categories of factors that impact dietary choices. These factors may be important in building interventions to improve diets.
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Stepanchuk, Aleksandr Pavlovich, e Tatyana Anatolevna Cepkovkaya. "ОЦЕНКА ВОЗМОЖНОСТЬ ИСПОЛЬЗОВАНИЯ ПРИБЛИЖЕННЫХ МОДЕЛЕЙ ПРИ ОЦЕНКИ СРЕДНЕЙ ХАРАКТЕРИСТИК РАССЕЯНИЯ ЭЛЕКТРОМАГНИТНЫХ ВОЛН". Научный взгляд в будущее, n.º 09-01 (30 de abril de 2018): 45–49. http://dx.doi.org/10.30888/2415-7538.2018-09-01-049.

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Рассмотрена задача рассеяния электромагнитных волн на полой структуре. Рассмотрены полые структуры простой формы и сложные с конечной нагрузкой. Для характеристики этих структур используется метод интегральных уравнений, интегральных уравнений на основе м
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Nomura, Takaaki, e Hiroshi Okada. "A linear seesaw model with A 4-modular flavor and local U(1) B-L symmetries". Journal of Cosmology and Astroparticle Physics 2022, n.º 09 (1 de setembro de 2022): 049. http://dx.doi.org/10.1088/1475-7516/2022/09/049.

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Abstract We discuss a linear seesaw model with local U(1) B-L and modular A 4 symmetries. The neutrino mass matrix for linear seesaw mechanism is realized by U(1) B-L charge assignment and the nature of modular A 4 symmetry. We formulate neutrino mass and carry out numerical χ square analysis showing some predictions for observables in neutrino sector.
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Reynolds, Andrew R. "Potential Relevance of Bell-Shaped and U-Shaped Dose-Responses for the Therapeutic Targeting of Angiogenesis in Cancer". Dose-Response 8, n.º 3 (23 de abril de 2010): dose—response.0. http://dx.doi.org/10.2203/dose-response.09-049.reynolds.

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6

Jin, Hong-Bo, Yue-Liang Wu e Yu-Feng Zhou. "Cosmic ray propagation and dark matter in light of the latest AMS-02 data". Journal of Cosmology and Astroparticle Physics 2015, n.º 09 (21 de setembro de 2015): 049. http://dx.doi.org/10.1088/1475-7516/2015/09/049.

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Kalousios, Chrysostomos, C. Vergu e Anastasia Volovich. "Factorized tree-level scattering inAdS4× ℂℙ3". Journal of High Energy Physics 2009, n.º 09 (8 de setembro de 2009): 049. http://dx.doi.org/10.1088/1126-6708/2009/09/049.

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Kiczek, Bartłomiej, e Marek Rogatko. "Ultra-compact spherically symmetric dark matter charged star objects". Journal of Cosmology and Astroparticle Physics 2019, n.º 09 (24 de setembro de 2019): 049. http://dx.doi.org/10.1088/1475-7516/2019/09/049.

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9

Solomon, Adam R., e Mark Trodden. "Non-canonical kinetic structures in the swampland". Journal of Cosmology and Astroparticle Physics 2020, n.º 09 (28 de setembro de 2020): 049. http://dx.doi.org/10.1088/1475-7516/2020/09/049.

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10

Chu, Chong-Sun, e Konstantinos Kyritsis. "Local Commutativity and Causality in Interacting PP-wave String Field Theory". Journal of High Energy Physics 2004, n.º 09 (22 de setembro de 2004): 049. http://dx.doi.org/10.1088/1126-6708/2004/09/049.

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11

Duffy, Gavin, Christopher M. Harris, Panagiota Kanti e Elizabeth Winstanley. "Brane decay of a (4+n)-dimensional rotating black hole: spin-0 particles". Journal of High Energy Physics 2005, n.º 09 (21 de setembro de 2005): 049. http://dx.doi.org/10.1088/1126-6708/2005/09/049.

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12

Banks, Tom, Matt Johnson e Assaf Shomer. "A note on gauge theories coupled to gravity". Journal of High Energy Physics 2006, n.º 09 (20 de setembro de 2006): 049. http://dx.doi.org/10.1088/1126-6708/2006/09/049.

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13

Litim, Daniel F., e Jan M. Pawlowski. "Renormalisation group flows for gauge theories in axial gauges". Journal of High Energy Physics 2002, n.º 09 (23 de setembro de 2002): 049. http://dx.doi.org/10.1088/1126-6708/2002/09/049.

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Maccaferri, Carlo, e Davide Mamone. "Star democracy in open string field theory". Journal of High Energy Physics 2003, n.º 09 (20 de setembro de 2003): 049. http://dx.doi.org/10.1088/1126-6708/2003/09/049.

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15

Koch, Robert de Mello, Jelena Smolic e Milena Smolic. "Giant gravitons—with strings attached (II)". Journal of High Energy Physics 2007, n.º 09 (11 de setembro de 2007): 049. http://dx.doi.org/10.1088/1126-6708/2007/09/049.

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16

Kitazawa, Noriaki. "One-loop masses of open-string scalar fields in string theory". Journal of High Energy Physics 2008, n.º 09 (10 de setembro de 2008): 049. http://dx.doi.org/10.1088/1126-6708/2008/09/049.

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17

Meiksins, Peter. "Confronting the Time Bind: Work, Family, and Capitalism". Monthly Review 49, n.º 9 (1 de fevereiro de 1998): 1. http://dx.doi.org/10.14452/mr-049-09-1998-02_1.

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18

Kennedy, Simon. "New Labour and the Reorganization of British Politics". Monthly Review 49, n.º 9 (2 de fevereiro de 1998): 14. http://dx.doi.org/10.14452/mr-049-09-1998-02_2.

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Mészáros, István. "The Uncontrollability of Globalizing Capital—Intro to Beyond Capital". Monthly Review 49, n.º 9 (3 de fevereiro de 1998): 27. http://dx.doi.org/10.14452/mr-049-09-1998-02_3.

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20

Noble, David. "Digital Diploma Mills: The Automation of Higher Education". Monthly Review 49, n.º 9 (4 de fevereiro de 1998): 38. http://dx.doi.org/10.14452/mr-049-09-1998-02_4.

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21

Street, Paul. "The Judas Economy and the Limits of Acceptable Debate". Monthly Review 49, n.º 9 (5 de fevereiro de 1998): 53. http://dx.doi.org/10.14452/mr-049-09-1998-02_5.

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22

Catena, Riccardo. "Analysis of the theoretical bias in dark matter direct detection". Journal of Cosmology and Astroparticle Physics 2014, n.º 09 (30 de setembro de 2014): 049. http://dx.doi.org/10.1088/1475-7516/2014/09/049.

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23

Kazakov, D. I., R. M. Iakhibbaev e D. M. Tolkachev. "Leading all-loop quantum contribution to the effective potential in the inflationary cosmology". Journal of Cosmology and Astroparticle Physics 2023, n.º 09 (1 de setembro de 2023): 049. http://dx.doi.org/10.1088/1475-7516/2023/09/049.

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Abstract In this paper, we have constructed quantum effective potentials and used them to study slow-roll inflationary cosmology. We derived the generalised RG equation for the effective potential in the leading logarithmic approximation and applied it to evaluate the potentials of the T 2 and T 4-models, which are often used in modern models of slow-roll inflation. We found that while the one-loop correction strongly affects the potential, breaking its original symmetry, the contribution of higher loops smoothes the behaviour of the potential. However, unlike the ϕ 4-case, we found that the effective potentials preserve spontaneous symmetry breaking when summing all the leading corrections. We calculated the spectral indices ns and r for the effective potentials of both models and found that they are consistent with the observational data for a wide range of parameters of the models.
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Koutsioumpa, Evangelia, Demosthenes Makris, Athina Theochari, Dimitra Bagka, Stathis Stathakis, Efstratios Manoulakas, Markos Sgantzos e Epaminondas Zakynthinos. "Effect of Transcutaneous Electrical Neuromuscular Stimulation on Myopathy in Intensive Care Patients". American Journal of Critical Care 27, n.º 6 (1 de novembro de 2018): 495–503. http://dx.doi.org/10.4037/ajcc2018311.

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Background Critical illness polyneuropathy or myopathy is a severe disorder that may adversely affect patients in the intensive care unit, resulting in reduced mobilization, decline in muscle mass, and prolonged recovery periods. Objective To examine whether the application of trans-cutaneous electrical neuromuscular stimulation (TENMS) reduces the incidence or severity of myopathy related to critical illness in intensive care unit patients. Methods A total of 80 patients aged 18 years or older with an intensive care unit stay of 96 hours or more and receipt of mechanical ventilation for 96 hours or more were initially enrolled in a prospective, open-label randomized controlled trial in a university hospital. Patients received either conventional physical therapy alone (control group) or conventional physical therapy plus TENMS (TENMS group) for 10 days. Myopathy was assessed histologically (by needle biopsy of the quadriceps muscles) on the 4th and 14th days of the intensive care unit stay. Results Of the 68 patients who completed the study, 27 (40%) had myopathy on the 14th day: 11 patients in the TENMS group (9 mild, 1 moderate, and 1 severe) and 16 patients in the control group (13 mild, 2 moderate, and 1 severe). Patients who progressed from mild to moderate or severe myopathy between the 4th and 14th days had significantly lower body mass index (P = .001) and longer time periods with inadequate nutrition (P = .049) compared with the other patients. Mean (SD) Rankin scale scores at 6 months were 3.2 (1.8) and 3.8 (2.1) in the TENMS and control groups, respectively (P = .09). Conclusion TENMS had no significant impact on myopathy in the critically ill patients in this study.
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Trubenstein, Brittany P., Robin Corley, Kyle D. Gebelin, Sergio Rey, Sally Wadsworth e Chandra A. Reynolds. "ACTIVITIES ACROSS AMERICA: EVALUATING GEOGRAPHIC DIFFERENCES IN ACTIVITY ENGAGEMENT". Innovation in Aging 3, Supplement_1 (novembro de 2019): S214. http://dx.doi.org/10.1093/geroni/igz038.784.

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Abstract Rurality is associated with cognitive health disparities. We investigated proximal and distal indices of rurality, activity engagement and cognitive performance in the ongoing Colorado Adoption/Twin Study of Lifespan behavioral development and cognitive aging (CATSLife; N = 979; 47% female). The Index of Relative Rurality (IRR) (0 = Urban to 1= Rural) was calculated using population density, population, percent urban, and remoteness at the census tract (IRRtract; M=0.40,SD =.05) and county levels (IRRcounty; M=0.53, SD=.09), which were moderately correlated (r = .21, p = .000). Individuals reported weekly-hours of engagement in 19 activities, classified into social (M=6.85, SD=4.03), physical (M=6.53, SD=4.76), family (M=10.76, SD=7.06), sedentary (M=11.84, SD=5.83), or cognitive (M=4.63, SD=3.74) domains. Social activities correlated with IRRcounty (r=0.091, p = .005) but not with IRRtract (r=-0.004). WAIS-III IQ scores were available. Social activities modestly correlated with IQ, particularly Verbal-IQ (r = .063, p = .049). Cognitive activities correlated with all IQ measures (r’s = .17 to .25, p < .000). While IRRcounty correlated positively with IQ (r’s=0.057 to 0.094, p’s = .079 to .000), IRRtract correlated negatively but not significantly with IQ (r’s=-0.053 to -0.062, p’s = .104 - .054). Analyses accounting for family nesting, sex, and age suggested compensatory associations between IRRcounty versus IRRtract and Full-Scale-IQ (p < .019), with similar patterns for Verbal-IQ and Performance-IQ. Social activities did not uniquely contribute. Further investigation is warranted to better understand the complex relationships between proximal and distal rurality and the implications that these relationships have on activity engagement and cognitive performance.
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Kamal, Arif H., Janet Bull, Steven P. Wolf, Diane Portman, Jacob Strand e Kimberly S. Johnson. "Unmet Needs of African Americans and Whites at the Time of Palliative Care Consultation". American Journal of Hospice and Palliative Medicine® 34, n.º 5 (16 de fevereiro de 2016): 461–65. http://dx.doi.org/10.1177/1049909116632508.

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Context: Differences among patient populations that present to consultative palliative care are not known. Such an appreciation would inform health-care delivery tailored to unique populations. Objectives: We aimed to compare characteristics and palliative care needs of African Americans (AAs) and whites during initial palliative care consultation. Methods: We analyzed patient-reported, clinician-entered clinical encounter data from a large, multisite community-based, nonhospice palliative care collaborative. We included first specialty palliative care consultations from January 1, 2014, to July 2, 2015, across 15 sites within the Global Palliative Care Quality Alliance registry. Demographics, disease, performance status, advance care planning, and symptom prevalence/severity were compared. Results: Of 775 patients, 12.9% (N = 100) were AA. African Americans were younger (63 vs 75.4 years, P < .0001). A larger proportion of AAs had a diagnosis of cancer (45.0% vs 36.3%, P = .09) and in the hospital (71% vs 61.8%, P = .07). African Americans were more likely to have a Palliative Performance Score of 0 to 30 (35.6% vs 23.7%, P = .049). Around 50% in both racial groups were full code; slightly more than 40% had an advance directive. Nearly two-thirds in both racial groups reported 3 or more symptoms of any severity; one-third reported 3 or more moderate or severe symptoms. A larger proportion of Africans than whites reported pain of any severity (66.0% vs 56.1%, P = .06). Conclusion: All patients present to palliative care consultations with significant symptom and advance care planning needs. Further research is needed to identify how to deliver palliative care: earlier, in noncancer conditions, and improve pain management in AA populations.
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Fünten, Karen aus der, Oliver Faude, Jochen Lensch e Tim Meyer. "Injury Characteristics in the German Professional Male Soccer Leagues After a Shortened Winter Break". Journal of Athletic Training 49, n.º 6 (1 de dezembro de 2014): 786–93. http://dx.doi.org/10.4085/1062-6050-49.3.51.

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Context: The winter break in the top 2 German professional soccer leagues was shortened from 6.5 to 3.5 weeks in the 2009–2010 season. Objective: To investigate whether this change affected injury characteristics by comparing the second half of the 2008–2009 (long winter break) with the equivalent period in the 2009–2010 season (short winter break). Design: Prospective cohort study. Setting: German male professional soccer leagues. Patients or Other Participants: Seven professional German male soccer teams (184 players in the 2008–2009 season, 188 players in the 2009–2010 season). Main Outcome Measure(s): Injury incidences and injury characteristics (cause of injury, location, severity, type, diagnosis), including their monthly distribution, were recorded. Results: A total of 300 time-loss injuries (2008–2009 n = 151, 2009–2010 n = 149) occurred. The overall injury incidence per 1000 soccer hours was 5.90 (95% confidence interval = 5.03, 6.82) in 2008–2009 and 6.55 (5.58, 7.69) in 2009–2010. Match injuries per 1000 hours were 31.5 (25.0, 38.0) in the first season and 26.5 (20.2, 32.7) in the second season; the corresponding training values were 2.67 (2.08–3.44) and 3.98 (3.19–4.95), respectively. The training injury incidence (incidence rate ratio = 1.49 [95% confidence interval = 1.07, 2.08], P = .02) and the risk of sustaining a knee injury (incidence rate ratio = 1.66 [1.00, 2.76], P = .049) were higher in 2009–2010 after the short winter break; the incidence of moderate and severe injuries (time loss &gt;7 days) trended higher (incidence rate ratio = 1.34 [0.96, 1.86], P = .09). Conclusions: Shortening the winter break from 6.5 to 3.5 weeks did not change the overall injury incidence; however, a higher number of training, knee, and possibly more severe injuries (time loss &gt;7 days) occurred.
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DeMott, Andrew, e Susan Hughes. "OUTCOMES OF FIT & STRONG! PLUS: A GROUP EXERCISE AND WEIGHT LOSS PROGRAM TO TREAT OSTEOARTHRITIS". Innovation in Aging 3, Supplement_1 (novembro de 2019): S611. http://dx.doi.org/10.1093/geroni/igz038.2274.

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Abstract Overweight older adults with osteoarthritis (OA) face increased risk for disability; however, no evidence-based programs target weight and OA simultaneously. Fit & Strong! (F&S!) is an 8-week evidence-based exercise program for persons with OA that improves lower extremity (LE) strength and mobility out to 18 months. F&S! Plus, a weight loss version of F&S! was tested against standard F&S! in a comparative effectiveness trial. Two and six-month trial outcomes were previously presented, this session will present maintenance outcomes at 12 and 18 months. This trial randomized 413 participants, 210 to F&S! and 203 to F&S! Plus. The mean sample age was 67.9, 86% female, and 92% African American. At 12 months, significant and marginally significant between-group differences favoring F&S! Plus were seen in several outcomes, including weight (p=.049), BMI (p=.04), waist circumference (p=.004), LE physical function (p=.09), 6-minute distance walk (mobility) (p=.08), 30-second chair stands (LE strength) (p=.46), and anxiety & depression (p=.08). At 18 months, only LE strength remained significantly improved for the F&S! Plus group (p=.045), however several within-group improvements remained statistically significant for both groups out to 18 months, including weight, BMI, waist circumference, LE pain & physical function, 30-second chair stands (LE strength), anxiety & depression, and self-efficacy for weight-management. F&S! Plus showed significant improvements over standard F&S! for several outcomes at the conclusion of the intervention (2 months) and many were maintained out to 12 months, with LE strength continuing to 18 months. Both groups showed significant within-group improvements out to 18 months.
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Fontana, Elisa, Gift Nyamundanda, David Cunningham, Dongsheng Tu, Maggie C. U. Cheang, Derek J. Jonker, Lillian L. Siu et al. "Intratumoral Transcriptome Heterogeneity Is Associated With Patient Prognosis and Sidedness in Patients With Colorectal Cancer Treated With Anti-EGFR Therapy From the CO.20 Trial". JCO Precision Oncology, n.º 4 (novembro de 2020): 1152–62. http://dx.doi.org/10.1200/po.20.00050.

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PURPOSE Metastatic colorectal cancers (mCRCs) assigned to the transit-amplifying (TA) CRCAssigner subtype are more sensitive to anti–epidermal growth factor receptor (EGFR) therapy. We evaluated the association between the intratumoral presence of TA signature (TA-high/TA-low, dubbed as TA-ness classification) and outcomes in CRCs treated with anti-EGFR therapy. PATIENTS AND METHODS The TA-ness classes were defined in a discovery cohort (n = 84) and independently validated in a clinical trial (CO.20; cetuximab monotherapy arm; n = 121) and other samples using an established NanoString-based gene expression assay. Progression-free survival (PFS), overall survival (OS), and disease control rate (DCR) according to TA-ness classification were assessed by univariate and multivariate analyses. RESULTS The TA-ness was measured in 772 samples from 712 patients. Patients (treated with anti-EGFR therapy) with TA-high tumors had significantly longer PFS (discovery hazard ratio [HR], 0.40; 95% CI, 0.25 to 0.64; P < .001; validation HR, 0.65; 95% CI, 0.45 to 0.93; P = .018), longer OS (discovery HR, 0.48; 95% CI, 0.29 to 0.78; P = .003; validation HR, 0.67; 95% CI, 0.46 to 0.98; P = .04), and higher DCR (discovery odds ratio [OR]; 14.8; 95% CI, 4.30 to 59.54; P < .001; validation OR, 4.35; 95% CI, 2.00 to 9.09; P < .001). TA-ness classification and its association with anti-EGFR therapy outcomes were further confirmed using publicly available data (n = 80) from metastatic samples (PFS P < .001) and patient-derived xenografts ( P = .042). In an exploratory analysis of 55 patients with RAS/BRAF wild-type and left-sided tumors, TA-high class was significantly associated with longer PFS and trend toward higher response rate (PFS HR, 0.53; 95% CI, 0.28 to 1.00; P = .049; OR, 5.88; 95% CI, 0.71 to 4.55; P = .09; response rate 33% in TA-high and 7.7% in TA-low). CONCLUSION TA-ness classification is associated with prognosis in patients with mCRC treated with anti-EGFR therapy and may further help understanding the value of sidedness in patients with RAS/BRAF wild-type tumors.
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Rayman, Margaret P., Sarah C. Bath, Jacob Westaway, Peter Williams, Jinyuan Mao, Jessica J. Vanderlelie, Anthony V. Perkins e Christopher W. G. Redman. "Selenium status in UK pregnant women and its relationship with hypertensive conditions of pregnancy". British Journal of Nutrition 113, n.º 2 (9 de janeiro de 2015): 249–58. http://dx.doi.org/10.1017/s000711451400364x.

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Dietary intake/status of the trace mineral Se may affect the risk of developing hypertensive conditions of pregnancy, i.e. pre-eclampsia and pregnancy-induced hypertension (PE/PIH). In the present study, we evaluated Se status in UK pregnant women to establish whether pre-pregnant Se status or Se supplementation affected the risk of developing PE/PIH. The samples originated from the SPRINT (Selenium in PRegnancy INTervention) study that randomised 230 UK primiparous women to treatment with Se (60 μg/d) or placebo from 12 weeks of gestation. Whole-blood Se concentration was measured at 12 and 35 weeks, toenail Se concentration at 16 weeks, plasma selenoprotein P (SEPP1) concentration at 35 weeks and plasma glutathione peroxidase (GPx3) activity at 12, 20 and 35 weeks. Demographic data were collected at baseline. Participants completed a FFQ. UK pregnant women had whole-blood Se concentration lower than the mid-range of other populations, toenail Se concentration considerably lower than US women, GPx3 activity considerably lower than US and Australian pregnant women, and low baseline SEPP1 concentration (median 3·00, range 0·90–5·80 mg/l). Maternal age, education and social class were positively associated with Se status. After adjustment, whole-blood Se concentration was higher in women consuming Brazil nuts (P= 0·040) and in those consuming more than two seafood portions per week (P= 0·054). A stepwise logistic regression model revealed that among the Se-related risk factors, only toenail Se (OR 0·38, 95 % CI 0·17, 0·87,P= 0·021) significantly affected the OR for PE/PIH. On excluding non-compliers with Se treatment, Se supplementation also significantly reduced the OR for PE/PIH (OR 0·30, 95 % CI 0·09, 1·00,P= 0·049). In conclusion, UK women have low Se status that increases their risk of developing PE/PIH. Therefore, UK women of childbearing age need to improve their Se status.
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Park, Eunyoung, Indika Edirisinghe, Ying Yng Choy, Andrew Waterhouse e Britt Burton-Freeman. "Effects of grape seed extract beverage on blood pressure and metabolic indices in individuals with pre-hypertension: a randomised, double-blinded, two-arm, parallel, placebo-controlled trial". British Journal of Nutrition 115, n.º 2 (16 de novembro de 2015): 226–38. http://dx.doi.org/10.1017/s0007114515004328.

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AbstractThe aim of the present study was to test grape seed extract (GSE) as a functional ingredient to lower blood pressure (BP) in individuals with pre-hypertension. A single-centre, randomised, two-arm, double-blinded, placebo-controlled, 12-week, parallel study was conducted in middle-aged adults with pre-hypertension. A total of thirty-six subjects were randomised (1:1) to Placebo (n 18) or GSE (n 18) groups; twenty-nine of them completed all the protocol-specified procedures (Placebo, n 17; GSE, n 12). Subjects consumed a juice (167 kJ (40 kcal)) containing 0 mg (Placebo) or 300 mg/d GSE (150 mg) twice daily for 6 weeks preceded by a 2-week Placebo run-in and followed by 4-week no-beverage follow-up. Compliance was monitored. BP was measured at screening, 0, 6 and 10 weeks of intervention and blood samples were collected at 0, 3, 6 and 10 weeks of intervention. GSE significantly reduced systolic BP (SBP) by 5·6 % (P=0·012) and diastolic BP (DBP) by 4·7 % (P=0·049) after 6 weeks of intervention period, which was significantly different (SBP; P=0·03) or tended to be different (DBP; P=0·08) from Placebo. BP returned to baseline after the 4-week discontinuation period of GSE beverage. Subjects with higher initial BP experienced greater BP reduction; nearly double the effect size. Fasting insulin and insulin sensitivity tended to improve after 6 weeks of GSE beverage supplementation (P=0·09 and 0·07, respectively); no significant changes were observed with fasting plasma lipids, glucose, oxidised LDL, flow-mediated dilation or vascular adhesion molecules. Total plasma phenolic acid concentrations were 1·6 times higher after 6 weeks of GSE v. Placebo. GSE was found to be safe and to improve BP in people with pre-hypertension, supporting the use of GSE as a functional ingredient in a low-energy beverage for BP control.
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Kosmadopoulos, Anastasi, Philippe Boudreau e Diane Boivin. "285 Pilot field study of Ambulatory Sleep-Staging in Shift-Working Air Traffic Controllers". Sleep 44, Supplement_2 (1 de maio de 2021): A114. http://dx.doi.org/10.1093/sleep/zsab072.284.

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Abstract Introduction The simplicity of wrist actigraphy for sleep-wake monitoring in the field contributes to its ubiquity in shift-work research. However, devices based solely on recording activity levels are generally not suitable to quantify sleep architecture. This is a limitation as quantifying changes in sleep stages caused by circadian misalignment is important to better assess the consequences of sleep-wake disruption in shift-working populations. This pilot study was conducted to evaluate whether sleep stages vary with respect to different shift types. Methods Six male air traffic controllers aged 48.5±8.4 years (mean±SD) completed the protocol which entailed two ~9-day periods, each with up to 6 workdays. Schedules comprised 1 or 2 early night shifts (19:30–03:30h), followed by an evening shift (15:00–23:00h), day shift (09:00–17:00h), morning shift (06:30–14:30h), and 1 or 2 full night shifts (23:00–7:00h). A portable sleep-staging device (Somno-Art, Paris, France) that monitored activity levels and heart rate was worn on the non-dominant forearm during bedtime and produced estimates of REM and NREM sleep stages with a proprietary algorithm. Total sleep time (TST) and sleep stages were assessed per shift type with mixed-effects models. Results Final analyses were based on 70 sleep periods preceding workdays, standardized to 24 h to account for the different intervals between consecutive shifts. Analyses revealed significant effects of shift type for TST (p=.016), stages N1 (p=.010) and N2 (p=.043), but none for N3 (p=.055) or REM (p=.117) sleep. TST and stage N1 sleep prior to night shifts was shorter than for day, evening, or early night shifts (all p&lt;.05). Participants obtained less stage N2 sleep prior to night shifts than days shifts (p=.049). Conclusion This pilot study suggests variations in TST across shifts were predominantly due to differences in light sleep stages, whereas no significant differences in N3 and REM sleep were observed. Thus, while TST was reduced for night shifts, participants obtained similar durations of the most recuperative stages. These findings highlight the importance of refined monitoring of sleep in field research involving shift-work. Support (if any) Project funded by NAV Canada. Devices lent by the Somno-Art company. A.K. received a postdoctoral fellowship from the Fonds de Recherche en Santé du Québec (FRQS).
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Hartman, Sheri J., Lauren S. Weiner, Sandahl H. Nelson, Loki Natarajan, Ruth E. Patterson, Barton W. Palmer, Barbara A. Parker e Dorothy D. Sears. "Mediators of a Physical Activity Intervention on Cognition in Breast Cancer Survivors: Evidence From a Randomized Controlled Trial". JMIR Cancer 5, n.º 2 (11 de outubro de 2019): e13150. http://dx.doi.org/10.2196/13150.

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Background Emerging research suggests that increasing physical activity can help improve cognition among breast cancer survivors. However, little is known about the mechanism through which physical activity impacts cancer survivors’ cognition. Objective The objective of this secondary analysis examined physical and psychological function potentially linking physical activity with changes in cognition among breast cancer survivors in a randomized controlled trial where the exercise arm had greater improvements in cognition than the control arm. Methods A total of 87 sedentary breast cancer survivors were randomized to a 12-week physical activity intervention (n=43) or control condition (n=44). Objectively measured processing speed (National Institutes of Health Toolbox Oral Symbol Digit), self-reported cognition (patient-reported outcomes measurement information system [PROMIS] cognitive abilities), PROMIS measures of physical and psychological function (depression, anxiety, fatigue, and physical functioning), and plasma biomarkers (brain-derived neurotrophic factor, homeostatic model assessment 2 of insulin resistance, and C-reactive protein [CRP]) were collected at baseline and 12 weeks. Linear mixed-effects models tested intervention effects on changes in physical and psychological function variables and biomarkers. Bootstrapping was used to assess mediation. Exploratory analyses examined self-reported cognitive abilities and processing speed as mediators of the intervention effect on physical functioning. Results Participants in the exercise arm had significantly greater improvements in physical functioning (beta=1.23; 95% CI 2.42 to 0.03; P=.049) and reductions in anxiety (beta=−1.50; 95% CI −0.07 to −2.94; P=.04) than those in the control arm. Anxiety significantly mediated the intervention effect on cognitive abilities (bootstrap 95% CI −1.96 to −0.06), whereas physical functioning did not (bootstrap 95% CI −1.12 to 0.10). Neither anxiety (bootstrap 95% CI −1.18 to 0.74) nor physical functioning (bootstrap 95% CI −2.34 to 0.15) mediated the intervention effect on processing speed. Of the biomarkers, only CRP had greater changes in the exercise arm than the control arm (beta=.253; 95% CI −0.04 to 0.57; P=.09), but CRP was not associated with cognition; therefore, none of the biomarker measures mediated the intervention effect on cognition. Neither cognitive abilities (bootstrap 95% CI −0.06 to 0.68) nor processing speed (bootstrap 95% CI −0.15 to 0.63) mediated the intervention effect on physical function. Conclusions Physical activity interventions may improve self-reported cognition by decreasing anxiety. If supported by larger studies, reducing anxiety may be an important target for improving self-reported cognition among cancer survivors. Trial Registration ClinicalTrials.gov NCT02332876; https://clinicaltrials.gov/ct2/show/NCT02332876
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Howard, Matthew T., Brad Pohlman, Tao Jin e Eric Hsi. "Are Mast Cells a Biologic Predictor of Outcome in Follicular Lymphoma?" Blood 112, n.º 11 (16 de novembro de 2008): 3772. http://dx.doi.org/10.1182/blood.v112.11.3772.3772.

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Abstract Background: The tumor microenvironment is important in the biology of follicular lymphoma (FL). In addition to macrophages, which have been shown to be associated with outcome in FL, mast cells (MCs) have the ability to influence the microenvironment through secretion of numerous biologically active molecules such as growth factors and cytokines/chemokines. Increased numbers of tumor-infiltrating MCs have been suggested as an unfavorable prognostic marker that also supercedes the predictive value of lymphoma-associated macrophages (LAM) in FL patients treated with immunochemotherapy. This study examines the effects of tumor-infiltrating MCs in FL patients at Cleveland Clinic. Design: Tissue microarrays were constructed from 94 newly diagnosed cases of FL from 09/01/1985 to 12/13/2002 that had been previously characterized for CD68+ LAMs and demonstrated that extrafollicular (EF) LAMs (>16.8/high power field) were a poor prognostic marker (Kelley T et al 2007). Immunohistochemistry for tryptase was performed on these microarrays to enumerate MCs per high powered (400x) field. In each core, all available lymphomatous tissue was evaluated (mean of 8.13 hpf/case, range 1–9). The cell counts were compared to the available clinical follow-up data, using overall survival as the measurable outcome. Results: The FL patients (44 women, 50 men) had a mean age at diagnosis of 59 years and a mean follow-up of 95.8 months. The patients were treated heterogeneously; the great majority did not receive immunochemotherapy as initial treatment. MC data was available in 91 patients. The mean MC count was 4.14 MCs/hpf (range 0–17.33). As shown previously, > 16.8 EF LAMs/hpf was a predictor of poor overall survival; hazard ratio of 2.28, 95% CI: 1.22–4.24, P = .009. In the entire cohort, MCs were not associated with overall survival. However, in the subgroup with low LAM (CD68 <16.8/hpf), increased MCs (>3.3/hpf) was associated with better overall survival, HR = 0.40, 95% CI: 0.16–0.99, P = .049. Conclusion: In our data set, increased LAMs in FL are associated with poor overall survival. Overall, MCs do not appear to predict outcome; however, in the subgroup of patients with low LAMs, increased MCs are associated with a favorable overall survival. This suggests a complex interaction between cellular constituents of the tumor microenvironment that affects patient outcome. The application of immunochemotherapy or other immunomodulatory therapies may alter these interactions and outcomes. Further work is needed to better understand these interactions and to validate biomarkers in therapy specific contexts.
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Woodcock, Claire, Brent Mittelstadt, Dan Busbridge e Grant Blank. "The Impact of Explanations on Layperson Trust in Artificial Intelligence–Driven Symptom Checker Apps: Experimental Study". Journal of Medical Internet Research 23, n.º 11 (3 de novembro de 2021): e29386. http://dx.doi.org/10.2196/29386.

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Background Artificial intelligence (AI)–driven symptom checkers are available to millions of users globally and are advocated as a tool to deliver health care more efficiently. To achieve the promoted benefits of a symptom checker, laypeople must trust and subsequently follow its instructions. In AI, explanations are seen as a tool to communicate the rationale behind black-box decisions to encourage trust and adoption. However, the effectiveness of the types of explanations used in AI-driven symptom checkers has not yet been studied. Explanations can follow many forms, including why-explanations and how-explanations. Social theories suggest that why-explanations are better at communicating knowledge and cultivating trust among laypeople. Objective The aim of this study is to ascertain whether explanations provided by a symptom checker affect explanatory trust among laypeople and whether this trust is impacted by their existing knowledge of disease. Methods A cross-sectional survey of 750 healthy participants was conducted. The participants were shown a video of a chatbot simulation that resulted in the diagnosis of either a migraine or temporal arteritis, chosen for their differing levels of epidemiological prevalence. These diagnoses were accompanied by one of four types of explanations. Each explanation type was selected either because of its current use in symptom checkers or because it was informed by theories of contrastive explanation. Exploratory factor analysis of participants’ responses followed by comparison-of-means tests were used to evaluate group differences in trust. Results Depending on the treatment group, two or three variables were generated, reflecting the prior knowledge and subsequent mental model that the participants held. When varying explanation type by disease, migraine was found to be nonsignificant (P=.65) and temporal arteritis, marginally significant (P=.09). Varying disease by explanation type resulted in statistical significance for input influence (P=.001), social proof (P=.049), and no explanation (P=.006), with counterfactual explanation (P=.053). The results suggest that trust in explanations is significantly affected by the disease being explained. When laypeople have existing knowledge of a disease, explanations have little impact on trust. Where the need for information is greater, different explanation types engender significantly different levels of trust. These results indicate that to be successful, symptom checkers need to tailor explanations to each user’s specific question and discount the diseases that they may also be aware of. Conclusions System builders developing explanations for symptom-checking apps should consider the recipient’s knowledge of a disease and tailor explanations to each user’s specific need. Effort should be placed on generating explanations that are personalized to each user of a symptom checker to fully discount the diseases that they may be aware of and to close their information gap.
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Poppe, Louise, Ilse De Bourdeaudhuij, Maïté Verloigne, Samyah Shadid, Jelle Van Cauwenberg, Sofie Compernolle e Geert Crombez. "Efficacy of a Self-Regulation–Based Electronic and Mobile Health Intervention Targeting an Active Lifestyle in Adults Having Type 2 Diabetes and in Adults Aged 50 Years or Older: Two Randomized Controlled Trials". Journal of Medical Internet Research 21, n.º 8 (2 de agosto de 2019): e13363. http://dx.doi.org/10.2196/13363.

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Background Adopting an active lifestyle plays a key role in the prevention and management of chronic diseases such as type 2 diabetes mellitus (T2DM). Web-based interventions are able to alter health behaviors and show stronger effects when they are informed by a behavior change theory. MyPlan 2.0 is a fully automated electronic health (eHealth) and mobile health (mHealth) intervention targeting physical activity (PA) and sedentary behavior (SB) based on the Health Action Process Approach (HAPA). Objective This study aimed to test the short-term effect of MyPlan 2.0 in altering levels of PA and SB and in changing personal determinants of behavior in adults with T2DM and in adults aged ≥50 years. Methods The study comprised two randomized controlled trials (RCTs) with an identical design. RCT 1 was conducted with adults with T2DM. RCT 2 was performed in adults aged ≥50 years. Data were collected via face-to-face assessments. The participants decided either to increase their level of PA or to decrease their level of SB. The participants were randomly allocated with a 2:1 ratio to the intervention group or the waiting-list control group. They were not blinded for their group allocation. The participants in the intervention group were instructed to go through MyPlan 2.0, comprising 5 sessions with an interval of 1 week between each session. The primary outcomes were objectively measured and self-reported PA (ie, light PA, moderate-to-vigorous PA, total PA, number of steps, and domain-specific [eg, transport-related] PA) and SB (ie, sitting time, number of breaks from sitting time, and length of sitting bouts). Secondary outcomes were self-reported behavioral determinants for PA and SB (eg, self-efficacy). Separate linear mixed models were performed to analyze the effects of MyPlan 2.0 in the two samples. Results In RCT 1 (n=54), the PA intervention group showed, in contrast to the control group, a decrease in self-reported time spent sitting (P=.09) and an increase in accelerometer-measured moderate (P=.05) and moderate-to-vigorous PA (P=.049). The SB intervention group displayed an increase in accelerometer-assessed breaks from sedentary time in comparison with the control group (P=.005). A total of 14 participants of RCT 1 dropped out. In RCT 2 (n=63), the PA intervention group showed an increase for self-reported total PA in comparison with the control group (P=.003). Furthermore, in contrast to the control group, the SB intervention group decreased their self-reported time spent sitting (P=.08) and increased their accelerometer-assessed moderate (P=.06) and moderate-to-vigorous PA (P=.07). A total of 8 participants of RCT 2 dropped out. Conclusions For both the samples, the HAPA-based eHealth and mHealth intervention, MyPlan 2.0, was able to improve only some of the primary outcomes. Trial Registration ClinicalTrials.gov NCT03291171; http://clinicaltrials.gov/ct2/show/NCT03291171. ClinicalTrials.gov NCT03799146; http://clinicaltrials.gov/ct2/show/NCT03799146. International Registered Report Identifier (IRRID) RR2-10.2196/12413
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Rektorova, I. "O.049 Functional and structural imaging of cognitive deflcits in PD". Parkinsonism & Related Disorders 15 (dezembro de 2009): S13. http://dx.doi.org/10.1016/s1353-8020(09)70064-1.

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Oduro, Jennifer, Ronald Simon, Natalia Gorbokon, Christoph Fraune, Julia Bluhm, Vivian Scheuplein, Elisa Kieback, Matthias Obenaus, Thomas Blankenstein e Eugen Leo. "95 MAGE-A1 protein expression pattern in > 5,000 tumor and healthy tissue samples: Validation of MAGE-A1 as an ideal target for TCR-based cell therapy". Journal for ImmunoTherapy of Cancer 9, Suppl 2 (novembro de 2021): A104. http://dx.doi.org/10.1136/jitc-2021-sitc2021.095.

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BackgroundCancer testis antigens (CTAs) are considered attractive targets for T cell receptor (TCR)-based cellular therapies as their expression in healthy adults is considered restricted to the immune-privileged testis. However, low-level expression of some CTAs in healthy tissue has been observed, resulting in significant on-target/off-cancer toxicity. Melanoma associated antigen 1 (MAGE-A1) is a member of the MAGE-A CTA family, whose members are known to influence cellular signaling pathways through their E3 ubiquitin ligase-binding MAGE homology domain. MAGE-A proteins are frequently expressed in different cancer types, have been linked to oncogenic activity and their expression has been associated with poor prognosis.1 Literature data suggest that in healthy tissues MAGE-A1 is detected in testis, only, with one exception suggesting MAGE-A1 RNA expression in cerebellum and cerebrum.2 Therefore, to evaluate MAGE-A1 as a potential target for cellular immunotherapies, an in-depth analysis of MAGE-A1 expression in > 70 different healthy tissue types and > 5,000 cancer biopsies was conducted, aiming to assess if MAGE-A1 represents a valid and safe target.MethodsA MAGE-A1 antibody with high specificity (TK-AbMA1P) was identified and characterized for immunohistochemistry. A large panel of > 70 different healthy tissue types and > 5,000 tumor biopsies was explored and scored for MAGE-A1 expression by tissue microarray. Identified cancer entities with relevant MAGE-A1 expression were further investigated to assess spatial intratumoral MAGE-A1 expression distribution and expression consistency between primary tumor and lymph node/distant metastases.ResultsCharacterization of TK-AbMA1P demonstrated fully paralog-selective staining for MAGE-A1. Analysis of MAGE-A1 expression in over 70 different healthy tissues confirmed strictly selective expression of MAGE-A1 in testis. An extended analysis of various CNS tissues including cerebellum and cerebrum did not reveal any expression in CNS. The analysis of > 5,000 tumor biopsies showed significant MAGE-A1 expression in distinct subgroups of multiple major tumor types with high unmet medical need. Substantial expression was detected for example in non-small-cell lung cancer, various breast cancer subtypes, gastrointestinal and urogenital cancers, among others. Extended analysis of the MAGE-A1 positive tumors demonstrated highly homogenous and consistent spatial intratumoral distribution of MAGE-A1 expression as well as between primary tumor and metastases.ConclusionsThis analysis confirms that MAGE-A1 is a highly selectively expressed CTA and demonstrates relevant expression in various indications with high unmet medical need, suggesting that MAGE-A1 is an ideal target for highly potent TCR-based adoptive cell therapy.ReferencesWeon JL, Potts PR. The MAGE protein family and cancer. Curr Opin Cell Biol 2015;37:1–8.Morgan RA, Chinnasamy N, Abate-Daga D, Gros A, Robbins PF, Zheng Z, Dudley ME, Feldman SA, Yang JC, Sherry RM, Phan GQ, Hughes MS, Kammula US, Miller AD, Hessman CJ, Stewart AA, Restifo NP, Quezado MM, Alimchandani M, Rosenberg AZ, Nath A, Wang T, Bielekova B, Wuest SC, Akula N, McMahon FJ, Wilde S, Mosetter B, Schendel DJ, Laurencot CM, Rosenberg SA. Cancer regression and neurological toxicity following anti-MAGE-A3 TCR gene therapy. J Immunother 2013;36(2):133–51.Ethics ApprovalThis study was approved by the Ethics Commission of the Ärztekammer Hamburg; approval number WF-049/09. Participants gave informed consent before taking part.
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Papale, L. A., K. N. Paul, M. S. Martin, S. Tufik e A. Escayg. "049 MICE WITH SODIUM CHANNEL MUTATIONS SHOW SUBTYPE-SPECIFIC ALTERATIONS IN SLEEP ARCHITECTURE". Sleep Medicine 10 (dezembro de 2009): S14. http://dx.doi.org/10.1016/s1389-9457(09)70051-6.

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Suleyman, H., A. Hacimuftuoglu, E. Cadirci, A. Albayrak, B. Polat, H. H. Alp e Z. Halici. "P.1.c.049 Relation of proepileptic activity of indomethacin with adrenal gland hormones". European Neuropsychopharmacology 19 (setembro de 2009): S279—S280. http://dx.doi.org/10.1016/s0924-977x(09)70409-2.

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Muselier, A., M. Passemard, B. Mathieu, A. Bron e C. Garcher. "049 Intérêt de la Ciclosporine en collyre dans les kérato-conjonctivites chroniques de l’enfant". Journal Français d'Ophtalmologie 32 (abril de 2009): 1S31. http://dx.doi.org/10.1016/s0181-5512(09)73187-0.

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42

Chockalingam, P. S., W. Sun, M. Rivera-Bermudez, S. Glasson, J. Lee, S. Larsson, L. S. Lohmander, K. E. Georgiadis e E. A. Morris. "049 JOINT INJURY LEADS TO SIGNIFICANTLY INCREASED AGGRECANASE ACTIVITY IN HUMANS AND PRECLINICAL ANIMAL MODELS". Osteoarthritis and Cartilage 17 (setembro de 2009): S34—S35. http://dx.doi.org/10.1016/s1063-4584(09)60072-8.

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43

Hallak, J., C. Chaves, C. Marque, J. Crippa, I. Chaudhry, N. Husain, L. Wichert-Ana, J. Deakhi, A. Zuardi e S. Dursun. "P.3.c.049 Short-term improvement by minocycline added to olanzapine antipsychotic treatment in schizophrenia". European Neuropsychopharmacology 19 (setembro de 2009): S538—S539. http://dx.doi.org/10.1016/s0924-977x(09)70856-9.

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Virtanen, P. K. "PP-049 Capillary zone electropherogram detects charge-transfer in natural bis-benzyl-isoquinolines aimed at liver remedy". International Journal of Infectious Diseases 12 (novembro de 2008): S70. http://dx.doi.org/10.1016/s1201-9712(09)60200-9.

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Casalta, J., E. Botelho-Nevers, F. Thuny, G. Habib, F. Gouriet, D. Raoult, A. Riberi, F. Collart e H. Richet. "049 HOW MANAGEMENT-BASED APPROACH OF INFECTIOUS ENDOCARDITIS (IE) TREATMENT LED TO A DRAMATIC FALL IN MORTALITY". International Journal of Antimicrobial Agents 33 (junho de 2009): S19. http://dx.doi.org/10.1016/s0924-8579(09)70068-8.

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Rizvi, S. J., S. H. Kennedy, H. McNeely, P. Giacobbe, H. S. Mayberg e A. M. Lozano. "P.2.a.049 Functional outcome after 12 months of deep brain stimulation for treatment resistant major depressive disorder". European Neuropsychopharmacology 19 (setembro de 2009): S388—S389. http://dx.doi.org/10.1016/s0924-977x(09)70598-x.

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47

Hu, C. C., J. Q. Zhang, X. C. Wang, G. L. Li, Q. Wang e J. Cheng. "OL-049 Screening of proteins binding to HCV NS3 protein from human pancreas cDNA library by yeast two-hybrid". International Journal of Infectious Diseases 12 (novembro de 2008): S52. http://dx.doi.org/10.1016/s1201-9712(09)60146-6.

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48

Treon, Steven P., Andrew R. Branagan, Leukothea Ioakimidis, Jacob D. Soumerai, Christopher J. Patterson, Barry Turnbull, Parveen Wasi et al. "Long-term outcomes to fludarabine and rituximab in Waldenström macroglobulinemia". Blood 113, n.º 16 (16 de abril de 2009): 3673–78. http://dx.doi.org/10.1182/blood-2008-09-177329.

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AbstractWe report the long-term outcome of a multicenter, prospective study examining fludarabine and rituximab in Waldenström macroglobulinemia (WM). WM patients with less than 2 prior therapies were eligible. Intended therapy consisted of 6 cycles (25 mg/m2 per day for 5 days) of fludarabine and 8 infusions (375 mg/m2 per week) of rituximab. A total of 43 patients were enrolled. Responses were: complete response (n = 2), very good partial response (n = 14), partial response (n = 21), and minor response (n = 4), for overall and major response rates of 95.3% and 86.0%, respectively. Median time to progression for all patients was 51.2 months and was longer for untreated patients (P = .017) and those achieving at least a very good partial response (P = .049). Grade 3 or higher toxicities included neutropenia (n = 27), thrombocytopenia (n = 7), and pneumonia (n = 6), including 2 patients who died of non–Pneumocystis carinii pneumonia. With a median follow-up of 40.3 months, we observed 3 cases of transformation to aggressive lymphoma and 3 cases of myelodysplastic syndrome/acute myeloid leukemia. The results of this study demonstrate that fludarabine and rituximab are highly active in WM, although short- and long-term toxicities need to be carefully weighed against other available treatment options. This study is registered at clinicaltrials.gov as NCT00020800.
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Malcovati, Luca, Elli Papaemmanuil, David T. Bowen, Jacqueline Boultwood, Matteo G. Della Porta, Cristiana Pascutto, Erica Travaglino et al. "Clinical significance of SF3B1 mutations in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms". Blood 118, n.º 24 (8 de dezembro de 2011): 6239–46. http://dx.doi.org/10.1182/blood-2011-09-377275.

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Abstract In a previous study, we identified somatic mutations of SF3B1, a gene encoding a core component of RNA splicing machinery, in patients with myelodysplastic syndrome (MDS). Here, we define the clinical significance of these mutations in MDS and myelodysplastic/myeloproliferative neoplasms (MDS/MPN). The coding exons of SF3B1 were screened using massively parallel pyrosequencing in patients with MDS, MDS/MPN, or acute myeloid leukemia (AML) evolving from MDS. Somatic mutations of SF3B1 were found in 150 of 533 (28.1%) patients with MDS, 16 of 83 (19.3%) with MDS/MPN, and 2 of 38 (5.3%) with AML. There was a significant association of SF3B1 mutations with the presence of ring sideroblasts (P < .001) and of mutant allele burden with their proportion (P = .002). The mutant gene had a positive predictive value for ring sideroblasts of 97.7% (95% confidence interval, 93.5%-99.5%). In multivariate analysis including established risk factors, SF3B1 mutations were found to be independently associated with better overall survival (hazard ratio = 0.15, P = .025) and lower risk of evolution into AML (hazard ratio = 0.33, P = .049). The close association between SF3B1 mutations and disease phenotype with ring sideroblasts across MDS and MDS/MPN is consistent with a causal relationship. Furthermore, SF3B1 mutations are independent predictors of favorable clinical outcome, and their incorporation into stratification systems might improve risk assessment in MDS.
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Ju, Ying, Nan Hou, Jing Meng, Xiaoyan Wang, Xiaoning Zhang, Xiaoyan Wang, Jinjin Wang et al. "OL-049 T cell immunoglobulin- and mucin-domain-containing molecule-3 (Tim-3) mediates natural killer cell suppression in chronic hepatitis B". International Journal of Infectious Diseases 13 (agosto de 2009): S45. http://dx.doi.org/10.1016/s1201-9712(09)60378-7.

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