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Literatura científica selecionada sobre o tema "320/.01/1"

Autor: Grafiati

Publicado: 25 de julho de 2024

Última modificação: 31 de julho de 2024

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Artigos de revistas sobre o assunto "320/.01/1"

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Bracken, J., C. Coolens e B. Driscoll. "Sci-Sat AM(1): Planning - 01: Volumetric 4D Computed Tomography with a 320 Multi-Slice Scanner". Medical Physics 37, n.º 7Part3 (julho de 2010): 3907. http://dx.doi.org/10.1118/1.3476201.

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รัตนะ, วัชระ, ละมัย ร่มเย็น e สัญญาศรณ์ สวัสดิ์ไธสง. "ปัจจัยที่ส่งผลต่อประสิทธิภาพการดำเนินงานกองทุนหมู่บ้านและชุมชนเมืองในเขตอำเภอวานรนิวาส จังหวัดสกลนคร". Interdisciplinary Academic and Research Journal 4, n.º 2 (7 de abril de 2024): 507–28. http://dx.doi.org/10.60027/iarj.2024.274874.

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ภูมิหลังและวัตถุประสงค์: กองทุนหมู่บ้านมีวัตถุประสงค์เพื่อเป็นแหล่งเงินทุนหมุนเวียนสำหรับการลงทุนเพื่อพัฒนาอาชีพ สร้างงาน สร้างรายได้ เพิ่มรายได้และลดรายจ่าย หรือสำหรับการส่งเสริมและพัฒนาไปสู่การสร้างสวัสดิภาพ สวัสดิการ หรือประโยชน์ส่วนรวมอื่นใดให้แก่ประชาชนในหมู่บ้านหรือชุมชนเมือง รวมถึงเป็นแหล่งเงินทุนหมุนเวียนเพื่อบรรเทาความเดือดร้อนเร่งด่วนสำหรับประชาชนในหมู่บ้านหรือชุมชนเมือง ดังนั้นการวิจัยครั้งนี้มีวัตถุประสงค์เพื่อศึกษา (1) ระดับภาวะผู้นำเชิงกลยุทธ์ การมีส่วนร่วมของประชาชน และประสิทธิภาพการดำเนินงานกองทุนหมู่บ้านและชุมชนเมืองในเขตอำเภอวานรนิวาส (2) อิทธิพลของภาวะผู้นำเชิงกลยุทธ์ และการมีส่วนร่วมของประชาชน ที่ส่งผลต่อประสิทธิภาพการดำเนินงานกองทุนหมู่บ้านและชุมชนเมืองในเขตอำเภอวานรนิวาส ระเบียบวิธีการวิจัย: กลุ่มตัวอย่าง ได้แก่ สมาชิกกองทุนหมู่บ้านและชุมชนเมืองในเขตอำเภอวานรนิวาส จังหวัดสกลนคร จำนวน 395 คน โดยใช้แบบสอบถามเป็นเครื่องมือในการเก็บรวบรวมข้อมูล และสถิติที่ใช้ในการวิเคราะห์ข้อมูลได้แก่ ความถี่ ร้อยละ ค่าเฉลี่ย ส่วนเบี่ยงเบนมาตรฐาน และการวิเคราะห์การถดถอยพหุคูณ ผลการวิจัย: (1) ภาวะผู้นำเชิงกลยุทธ์ของผู้นำหมู่บ้าน โดยภาพรวมอยู่ในระดับมาก การมีส่วนร่วมของประชาชนในการดำเนินงานกองทุนหมู่บ้านและชุมชนเมือง โดยภาพรวมอยู่ในระดับมาก และประสิทธิภาพการดำเนินงานกองทุนหมู่บ้านและชุมชนเมืองของอำเภอวานรนิวาส จังหวัดสกลนคร โดยภาพรวมอยู่ในระดับมาก (2) ภาวะผู้นำเชิงกลยุทธ์ด้านการควบคุมองค์การให้สมดุล (β=.320) ด้านการปฏิบัติอย่างมีคุณธรรม (β=.315) ด้านการกำหนดทิศทางเชิงกลยุทธ์ (β=.180) และด้านการสนับสนุนวัฒนธรรมองค์การที่มีประสิทธิผล (β=.147) มีอิทธิพลต่อภาวะผู้นำเชิงกลยุทธ์ที่ส่งผลต่อประสิทธิภาพการดำเนินงานกองทุนหมู่บ้านและชุมชนเมืองอย่างมีนัยสำคัญทางสถิติที่ระดับ .01 โดยสามารถร่วมกันทำนายระดับประสิทธิภาพการดำเนินงานกองทุนหมู่บ้านและชุมชนเมืองในเขตอำเภอวานรนิวาส ได้ร้อยละ 70.80 (R2Adj=.708) การมีส่วนร่วมของประชาชน ด้านการมีส่วนร่วมในการรับผลประโยชน์ (β=.436) และด้านการมีส่วนร่วมในการประเมินผล (β=.178) มีอิทธิพลต่อภาวะผู้นำเชิงกลยุทธ์ที่ส่งผลต่อประสิทธิภาพการดำเนินงานกองทุนหมู่บ้านและชุมชนเมือง อย่างมีนัยสำคัญทางสถิติที่ระดับ .01 ด้านการมีส่วนร่วมในการตัดสินใจ (β=.123) มีอิทธิพลต่อภาวะผู้นำเชิงกลยุทธ์ที่ส่งผลต่อประสิทธิภาพการดำเนินงานกองทุนหมู่บ้านและชุมชนเมือง อย่างมีนัยสำคัญทางสถิติที่ระดับ .05 โดยสามารถร่วมกันทำนายระดับประสิทธิภาพการดำเนินงานกองทุนหมู่บ้านและชุมชนเมืองในเขตอำเภอวานรนิวาส ได้ร้อยละ 46.60 (R2Adj=.466) สรุปผล: ผลการศึกษาชี้ให้เห็นถึงภูมิทัศน์เชิงบวกในอำเภอวานรนิวาส ซึ่งความเป็นผู้นำเชิงกลยุทธ์ระหว่างผู้นำหมู่บ้านและการมีส่วนร่วมของประชาชนมีบทบาทสำคัญในการขับเคลื่อนประสิทธิภาพการดำเนินงานที่สูงของกองทุนหมู่บ้านและชุมชนเมือง ปัจจัยที่ระบุ รวมถึงการควบคุมองค์กรที่สมดุล ความประพฤติทางศีลธรรม และการสนับสนุนวัฒนธรรมองค์กรที่แข็งแกร่ง เน้นย้ำถึงความเชื่อมโยงระหว่างผู้นำเชิงกลยุทธ์กับการดำเนินงานของกองทุนที่มีประสิทธิผล การมีส่วนร่วมของสาธารณะ โดยเฉพาะอย่างยิ่งในกระบวนการรับผลประโยชน์ การประเมิน และการตัดสินใจ มีส่วนช่วยอย่างมากต่อประสิทธิภาพการดำเนินงานโดยรวม การค้นพบนี้เน้นย้ำถึงลักษณะองค์รวมและการทำงานร่วมกันของการเป็นผู้นำและการมีส่วนร่วมของชุมชนเพื่อให้มั่นใจว่าการดำเนินงานกองทุนหมู่บ้านและชุมชนเมืองในอำเภอวานรนิวาสประสบความสำเร็จ

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Hawley, John A., Louise M. Burke, Damien J. Angus, Kieran E. Fallon, David T. Martin e Mark A. Febbraio. "Effect of altering substrate availability on metabolism and performance during intense exercise". British Journal of Nutrition 84, n.º 6 (dezembro de 2000): 829–38. http://dx.doi.org/10.1017/s0007114500002440.

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The purpose of this study was to determine the effect of altering substrate availability on metabolism and performance during intense cycling. Seven highly trained men ingested a random order of three isoenergetic meals 90 min before cycling at 80 % maximal oxygen uptake (VO2max) for 20 min (about 310 W), followed by a 600 kJ time trial lasting about 30 min. Meals consisted of either 1·2 g saturated fat/kg body mass (BM) with 3500 U heparin intravenously (HIFAT) to elevate circulating plasma free fatty acid (FA) concentration, 2·5 g carbohydrate/kg BM (CHO) to elevate plasma glucose and insulin concentrations or 2·5 g carbohydrate+20 mg nicotinic acid/kg BM (NA) to suppress lipolysis and reduce free FA concentration. HIFAT elevated free FA concentration (HIFAT 1·3 (SEM 0·2), CHO 0·2 (sem 0·1), NA 0·1 (sem 0·1) mm; P<0·001), lowered the RER (HIFAT 0·94 (sem 0·01), CHO 0·97 (sem 0·01), NA 0·98 (sem 0·01); P<0·01) and increased the rate of fat oxidation (HIFAT 24 (sem 3), CHO 12 (sem 2), NA 8 (sem 3) μmol/kg per min; P<0·01) during the 20 min ride. Marked differences in fat availability and fuel utilisation, however, had little effect on performance in the subsequent time trial (HIFAT 320 (sem 16), CHO 324 (sem 15), NA 315 (sem 13) W). We conclude: (1) increased fat availability during intense cycling increases the rate of fat oxidation; but (2) the reduction in the rate of carbohydrate oxidation in the presence of high circulating plasma free FA is unlikely to enhance intense exercise performance lasting about 1 h; (3) substrate selection during intense (about 80 % VO2max) exercise is dominated by carbohydrate oxidation.

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Vučajnk, Filip, Valentina Spanic, Stanislav Trdan, Iztok Jože Košir, Miha Ocvirk e Matej Vidrih. "Performance of Symmetric Double Flat Fan Nozzles against Fusarium Head Blight in Durum Wheat". Agriculture 14, n.º 3 (21 de fevereiro de 2024): 343. http://dx.doi.org/10.3390/agriculture14030343.

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Four types of nozzles were tested on large-scale trials with a 40 m2 plot unit size. The Avi Twin 110-01 (80 L ha−1), 110-02 (160 L ha−1), 110-03 (240 L ha−1), and 110-04 (320 L ha−1) symmetric double fan injector nozzles were tested during the 2020/2021 and 2021/2022 growing seasons. This study aimed to evaluate the performance of spray nozzles with regard to deoxynivalenol (DON) accumulation in durum wheat grains. Artificial inoculation with Fusarium spp. was performed after durum heads were protected with fungicide. The percentage of heads covered with fungicide droplets, grain yield, yield-related traits, technological quality parameters, and concentrations of DON were determined. Compared to the control (without fungicide treatment), the Avi Twin 04 nozzle caused a reduction of 45.0% in the DON concentration on average across both growing seasons. This positively corresponded to the percentage of heads covered with fungicide droplets, which was highest when this nozzle was utilized. In both trial years, the DON reduction caused by the 110-04 twin nozzle was higher than that caused by the 110-01 nozzle. Treatment with the 110-04 nozzle more effectively improved the grain yield, 1000-kernel weight, and test weight compared to treatment with the 110-01 nozzle and the untreated control. The differences in technological quality were less pronounced when different spray nozzles were used.

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Lynch, G. A., M. E. Hunt e S. N. McCutcheon. "A note on the effect of monensin sodium administered by intraruminal controlled-release devices on productivity of dairy cows at pasture". Animal Science 51, n.º 2 (outubro de 1990): 418–21. http://dx.doi.org/10.1017/s0003356100005572.

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The effects of monensin sodium, administered by intraruminal controlled-release devices at a rate of 320 mglday, on milk and milk solids production and bloat score were examined in a trial with 90 lactating dairy cows given only mixed ryegrasslwhite clover pasture. Monensintreated cows had significantly greater yields of milk and milk protein than control cows (1397·2 (s.e. 22·9) v. 1296·9 (s.e. 16·3) kg milk, 49·6 (s.e. 0·9) v. 46·5 (s.e. 0·6) kg protein) over the 14-week period of treatment (P < 0·01). Yield of fat was similar in monensin-treated and control cows (62·9 (s.e. 1·5) v. 63·4 (s.e. 1·1) kg). Live weight, condition score and bloat score were not influenced by treatment but pasture conditions were not conducive to severe bloat challenge.

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Rondinone, Valeria, Lorenzo Pace, Antonio Fasanella, Viviana Manzulli, Antonio Parisi, Maria Rosaria Capobianchi, Angelo Ostuni et al. "VOC 202012/01 Variant Is Effectively Neutralized by Antibodies Produced by Patients Infected before Its Diffusion in Italy". Viruses 13, n.º 2 (11 de fevereiro de 2021): 276. http://dx.doi.org/10.3390/v13020276.

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The coronavirus disease 2019 (Covid-19) pandemic is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and presents a global health emergency that needs urgent intervention. Viruses constantly change through mutation, and new variants of a virus are expected to occur over time. In the United Kingdom (UK), a new variant called B.1.1.7 has emerged with an unusually large number of mutations. The aim of this study is to evaluate the level of protection of sera from 12 patients infected and later healed in Apulia Region (Italy) with Covid-19 between March and November 2020, when the English variant was not circulating in this territory yet, against the new VOC 202012/01 variant by seroneutralization assay. The sera of patients had already been tested before, using a virus belonging to the lineage B.1 and showed an antibody neutralizing titer ranging between 1:160 and 1:320. All the 12 sera donors confirmed the same titers of neutralizing antibodies obtained with a strain belonging to the lineage B.1.1.7 (VOC 202012/01). These data indicate that antibodies produced in subjects infected with variants of Sars-CoV-2 strain before the appearance of the English one, seem to have a neutralizing power also against this variant.

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Delaney, Kerri Z., Leandra Spatari, Mélanie Henderson, Sylvia Santosa e Marie-Eve Mathieu. "Substrate Oxidation Is Altered by Obesity During Submaximal Cycling in Prepubertal and Early Pubertal Children: A Quality Study". Pediatric Exercise Science 33, n.º 1 (1 de fevereiro de 2021): 32–39. http://dx.doi.org/10.1123/pes.2020-0059.

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Background: To examine substrate oxidation in prepubertal and early pubertal children as a function of body weight, body composition, and sex during an exhaustive cycling test. Methods: This study included 320 children in prepubertal and early puberty (Tanner stage 1 or 2; n = 188 males) who completed a minimum of 4 stages (2–5 min/stage) of an adapted version of the McMaster exhaustive exercise protocol on an upright cycle ergometer. Substrate utilization, relative to individual VO2peak, was determined using VO2 and VCO2 data, obtained with breath-by-breath gas analysis during exercise. Results: Both peak (mg/kg lean body mass·min) and submaximal lipid oxidation (mg/kg lean body mass·min) were highest (P < .01) in children with healthy weight (HW), then overweight, and lowest in obese (OB). Both females with HW (compared with males with HW) and females with OB (compared with males with OB) had higher (P < .01) peak and submaximal lipid oxidation. In children with OB, fat-free mass correlated positively (P < .01) with submaximal lipid oxidation (r = .50). In contrast, in children with HW and overweight, fat-free mass correlated positively (P < .01) with carbohydrate oxidation (r = .52 and r = .47, respectively). Conclusion: Obesity during childhood may alter substrate oxidation during exercise. These results may have implications in the implementation of exercise programs in prepubertal or early puberty to control adiposity.

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Qiu, Chong-Rong, Qiang Fu, Jian Sui, Qian Zhang, Peng Wei, Yan Wu, Ke Zhu, Yi Lu e Peng Wan. "Analysis of Serum Endothelial Cell-Specific Molecule 1 (Endocan) Level in Type 2 Diabetes Mellitus With Acute ST-Segment Elevation Myocardial Infarction and its Correlation". Angiology 68, n.º 1 (29 de setembro de 2016): 74–78. http://dx.doi.org/10.1177/0003319716634581.

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Endothelial cell-specific molecule 1 (ESM-1; endocan) is expressed by endothelial cells, and it can be overexpressed in diabetic patients. However, little is known concerning diabetic patients with acute ST-segment elevation myocardial infarction (STEMI). Therefore, we assessed serum ESM-1 level in patients having type 2 diabetes mellitus (T2DM) STEMI; 72 patients with DM (38 with and 34 without vascular disease) and 33 individuals as a control group were included. There was a significant difference in serum ESM-1 level between the T2DM group and the control group ( P = .03). There was also a significant difference in serum ESM-1 level between the T2DM with STEMI group and newly diagnosed T2DM group without vascular disease ( P = .01). In patients with T2DM, serum ESM-1 levels correlated positively with high-sensitivity C-reactive protein levels and the neutrophil to lymphocyte ratio ( r = .321, P = .006 and r = .320, P = .006). Our findings suggest that serum ESM-1 level may be a novel endothelial dysfunction biomarker and it may be related to vascular disease in T2DM.

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Zhao, Youshan, Feng Xu, Juan Guo, Sida Zhao, Chunkang Chang e Xiao Li. "Dysregulation of ANKRD11 Influenced Hematopoisis By Histone Acetylation-Mediated Gene Expression in Myelodysplastic Syndrome". Blood 128, n.º 22 (2 de dezembro de 2016): 4292. http://dx.doi.org/10.1182/blood.v128.22.4292.4292.

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Abstract Background and Object In addition to histone deacetylation, the importance of histone over-acetylation induced oncogene transcription in initiation and progression of myelodysplastic syndrome (MDS) has been proposed recently. Our previous whole-exome sequencing identified a new somatic mutation, ANKRD11, an important factor in histone acetylation regulation. Its roles in MDS pathophysiology need to be clarified. Methods The next generation target sequencing (Including ANKRD11) was carried out in 320 patients with MDS using the MiSeq Benchtop Sequencer. ANKRD11 mRNA expression in bone marrow of MDS was measured by real-time PCR. Loss and gain of function assay were carried out in myeloid cell lines K562, MEG-01£¬or SKM-1 to observe the influence on cell proliferation and differentiation . The levels of histone acetylation at H3 and H4 were detected by Western blot. Results Target sequencing in a cohort of 320 MDS patients identified 14 of ANKRD11 mutations (4.38%, Fig.1), which were confirmed by Sanger sequencing. Meanwhile, no ANKRD11 mutations in 100 normal controls were defined. ANKRD11 mutations occurred frequently in exons 10 and 9. The mRNA expression levels of ANKRD11 were significantly decreased in MDS patients, especially in ANKRD11mutant patients (Fig.2). ANKRD11 knockdown in K562 and MEG-1 resulted in growth inhibition, cell cycle arrest and erythroid/megakaryocytic differentiation retardant. In MDS cell line SKM-1, the arrested differentiation was rescued by over-expression of ANKRD11. Consistent with a role for ANKRD11 in histone acetylation, ANKRD11 KD increased acetylation of histones H3 and H4 at H3K14 and H4K5 and resulted in the upregulation of genes involved in differentiation inhibilation (SOX6, P21, et al). Finally, the ANKRD11 KD-mediated influence on cell proliferation and differentiation were reversed by inhibiting histone acetyltransferase activity. Conclusion Our assay defined that ANKRD11 was a crucial chromatin regulator that suppress histone acetylation and then decrease gene expression during myeloid differentiation, providing a likely explanation for its role in MDS pathogenesis. This study further support histone acetylase inhibitor as a potential treatment in MDS. Figure ANKRD11mutation distribution (a) and coexist with other mutations (b). Figure. ANKRD11mutation distribution (a) and coexist with other mutations (b). Figure The mRNA expression levels of ANKRD11in our MDS (A, C) subset and GEO data (B). Figure. The mRNA expression levels of ANKRD11in our MDS (A, C) subset and GEO data (B). Changes of histone acetylation in ANKRD11-KD cell line (MEG-01). ANKRD11 KD significantly increased acetylation of histones H3 and H4 at H3K14 and H4K5. Changes of histone acetylation in ANKRD11-KD cell line (MEG-01). ANKRD11 KD significantly increased acetylation of histones H3 and H4 at H3K14 and H4K5. Disclosures No relevant conflicts of interest to declare.

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Bell, Hazel. "As I was saying: essays on the international book business by Gordon Graham London: Hans Zell. 320 pp, 1993. paperback £16.95. ISBN 1-873836-01-5". Learned Publishing 7, n.º 1 (janeiro de 1994): 63–64. http://dx.doi.org/10.1002/leap/70015br1.

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Mais fontes

Livros sobre o assunto "320/.01/1"

1

Ian, Shapiro, e Brilmayer Lea, eds. Global justice. New York: New York University Press, 1999.

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2

Laclau, Ernesto. Emancipation(s). New York: Verso, 1996.

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3

S, Richardson Henry, ed. Opponents and implications of A theory of justice. New York, USA: Garland Pub., 1999.

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4

Stephen, Everson, e Aristotle, eds. The Politics, and the Constitution of Athens. Cambridge: Cambridge University Press, 1996.

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5

John, Rawls. Justice as fairness: A restatement. Cambridge, Mass: Harvard University Press, 2001.

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6

Andros, Loizou, Lesser Harry, Northern Association for Philosophy (Great Britain) e Society for Greek Political Thought., eds. Polis and politics: Essays in Greek moral and political philosophy. Aldershot, Hants, England: Avebury, 1990.

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7

John, Rawls. A theory of justice. Cambridge, Mass: Belknap Press of Harvard University Press, 2005.

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John, Rawls. A Theory of Justice. S. l. b Harvard University Press c 09/1999: Belknap Press, 1999.

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John, Rawls. A theory of justice. Cambridge, Mass: Belknap Press of Harvard University Press, 1999.

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Godwin, William. An Enquiry Concerning Political Justice. Oxford, England: Oxford University Press, 2013.

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Capítulos de livros sobre o assunto "320/.01/1"

1

Lopes, Luiz Gustavo da Silva. "Estudo de análise de custo do BLOCOM parede pronta em conjunto habitacional no municipio do Iramduba/AM". In Tópicos especiais de Engenharia Civil - Volume 2. Editora Poisson, 2023. http://dx.doi.org/10.36229/978-65-5866-320-1.cap.01.

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Trabalhos de conferências sobre o assunto "320/.01/1"

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Salahudidin, Asif, Jamil A. Khan, L. David Smith e Chris L. Wilbur. "Critical Heat Flux (CHF) and Cold-Flow Pressure Drop Investigations of R-11 in a Vertical Uniformly Heated 5 x 5 Rod Bundle". In ASME 2005 Summer Heat Transfer Conference collocated with the ASME 2005 Pacific Rim Technical Conference and Exhibition on Integration and Packaging of MEMS, NEMS, and Electronic Systems. ASMEDC, 2005. http://dx.doi.org/10.1115/ht2005-72259.

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Experimental and numerical investigations were performed to determine the critical heat flux (CHF) and pressure drop in a vertical uniformly heated 5×5 rod bundle. R-11 is used as the working fluid due to its low latent heat, low critical pressure and well known properties. The experimental investigation was performed at the Westinghouse Nuclear Fuel PWR Product Technologies Test Laboratory in Columbia, South Carolina. Two types of grid designs were tested with Bundle-1 and Bundle-2 respectively. The matrix of DNB test parameters (water equivalent conditions shown in parentheses) includes exit pressure: 317–445 psia (1800–2400), inlet mass flux: 1.725–3.400 Mlbm/hr-ft2 (1.5–2.5 Mlbm/hr-ft2) and inlet temperature: 170–305°F (320–590 Mlbm/hr-ft2). Nominal R-11 conditions for the cold test are 165 psia, and 80°F±10°F. The experimental results were validated using a nuclear thermal hydraulic code VIPRE-01, MOD-02.1. The EPRI-1 correlation was being used to have a gross understanding of the CHF in the Bundles. Subsequently an empirical correlation USC11F was developed with Bundle-1 CHF database which compares favorably with experimental CHF for both the grid designs. Overall mean ratios of experimental to predicted CHF of 0.9984 and 0.9948 with standard deviations of 0.0265 and 0.0338 were obtained for Bundle-1 and Bundle-2 respectively. The predicted cold flow pressure drops also reproduced the experimental values closely. At lower mass flux a slight overprediction was encountered due to the dependability of mixing grid loss coefficient on Reynold’s number.

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Giannessi, D., R. De Caterina, G. Lazzerini, R. Sicari e P. Gazzetti. "RELATIVE SENSITIVITY OF CARDIAC PROSTACYCLIN AND THROMBOXANE TO INHIBITION BY NON-STEROIDAL ANTIINFLAMMATORY DRUGS IN THE RAT HEART". In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643390.

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We have previously shown that the isolated perfused rat Langendorff heart is able to synthesize detectable amounts of thromboxane (TX) A2, as well as prostacyclin (PGI2). Eicosanoid production in this system is increased during post-ischemic reperfusion, reflecting greater availability of substrate and net increase of synthesis. We assessed relative sensitivity of cyclooxygenases synthesizing TX and prostacyclin (probably located in different cell types) to aspirin (0.1, 0.5, 1 g/1), ibuprofen (1, 10, 80, 160, 320 mg/1) and diclofenac (0.01, 0.1, 0.5, 2.5, 5, 10, 25 mg/1), by radioimmunoassays of TXB2 and 6-keto-PGFα in the perfusate. Sixty Wistar male rat hearts were perfused with buffer containing control vehicle or drugs for 30 min, followed by 5 min clamping of the perfusion line and subsequent post-ischemic reperfusion. Baseline production was (mean±SD, pg/min/g wet weight) 754±261 and 143±66 for PGI2 and TXA2, respectively. Peak post-ischemic production was 7628±2673 and 1036±135, respectively. At doses of aspirin, ibuprofen and diclofenac (100, 10 and 2.5 mg/1, respectively) which were equally effective on prostacyclin production (mean % inhibition: 68, 67 and 72 for basal production and 90, 86 and 85 for peak post-ischemic production, respectively), % inhibition of TX production was consistently less, but also similar for the three drugs: 55, 58 and 56 for basal production and 78, 81 and 76 for peak post-ischemic production, for aspirin, ibuprofen and diclofenac, respectively; difference between inhibition of prostacyclin and TX: P < .01, difference for subsets among different drugs: N.S.). TX production was, on the contrary, selectively inhibited by the TX-synthase inhibitor 0KY 046 (by 79 and 92% at 0.1 mg/1, versus a complete sparing of prostacyclin production). The lesser sensitivity of cardiac (vascular?) TX versus prostacyclin to non-steroidal antiinflammatory drugs (NSAIDs) inhibition and the similar degree of inhibition by various NSAIDs, differing in structure and diffusing capacity, suggest heterogeneity among cyclooxygenases present in the system and different intrinsic sensitivity of TX- from prostacyclin-producing cyclooxygenases.

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