Literatura científica selecionada sobre o tema "2003 i-838"

RESUMEN:El objetivo del artículo es aproximarnos a la controvertida biografía del comisario Manuel Brabo Portillo. El trabajo está basado en fuentes primarias y secundarias. El método utilizado es empírico. En el imaginario del mundo sindicalista revolucionario, Brabo Portillo era el policía más odiado, la reencarnación de la cara más turbia del Estado. Fue, así mismo, un espía alemán relacionado con el hundimiento de barcos españoles, el asesinato del empresario e ingeniero Barret y el primer jefe de los terroristas vinculados a la patronal barcelonesa. La conflictividad que afectó a España en el período de la Primera Guerra Mundial es fundamental para entender los orígenes del terrorismo vinculado al pistolerismo, que marcó la historia político social española del primer tercio del siglo XX.PALABRAS CLAVE: Brabo Portillo, pistolerismo, espionaje, sindicalismo, Primera Guerra Mundial.ABSTRACT:The objective of the article is an approach to the controversial biography of Police Chief Manuel Brabo Portillo. The work is based on primary and secondary sources. The method used is empirical. In the imagery of the revolutionary syndicalist world, Brabo Portillo was the most hated policeman, the reincarnation of the murkiest face of the state. He was also a German spy connected with the sinking of Spanish ships, the murder of businessman and engineer Josep Barret and the first head of the terrorists linked to Barcelona employers. The conflict that affected Spain during the period of the First World War is fundamental in order to understand the origins of terrorism linked to pistolerismo, which marked Spanish social political history during the first third of the twentieth century.KEY WORDS: Brabo Portillo, pistolerismo, espionage, syndicalism, First World War. BIBLIOGRAFÍAAisa, M., La efervescencia social de los años 20. Barcelona 1917-1923, Barcelona, Descontrol, 2016.Aguirre de Cárcer, N., La neutralidad de España durante la Primera Guerra Mundial (1914-1918). I. Bélgica, Madrid, Ministerio de Asuntos Exteriores, 1995.Alonso, G., “’Afectos caprichosos’: Tradicionalismo y germanofilia en España durante la Gran Guerra”, Hispania Nova, 15, 2017, pp. 394-415.Amador, A., El Terror blanco en Barcelona. Las bombas y los atentados personales. Actuación infernal de una banda de asesinos al servicio de la burguesía. El asesinato como una industria, Tarragona, Talleres gráf. Gutenberg, [1920?].Anglés, C., “Contra los sindicatos. Los procesos de la organización obrera. La impostura nunca ha sido justicia”, Solidaridad Obrera, 836 (1/8/1918), p. 1.Balcells, A., El Pistolerisme. Barcelona (1917-1923), Barcelona, Pòrtic, 2009.Ben-Ami, S., La Dictadura de Primo de Rivera (1923-1930), Barcelona, Planeta, 1984.Bengoechea, S., Organització patronal i conflictivitat social a Catalunya. Tradició i corporativisme entre finals de segle i la dictadura de Primo de Rivera, Barcelona, PAM, 1994.Bengoechea, S., El locaut de Barcelona (1919-1920), Barcelona, Curial, 1998.Bengoechea, S., “1919: La Barcelona colpista. L’aliança de patrons i militars contra el sistema liberal”, Afers, 23/24 (1996), pp. 309-327.Brabo Portillo, M., Ensayo sobre policía científica, Barcelona, Gassó Hermanos, [190?].Bravo Portillo, M. y Samper, A., Programa para los exámenes de ingreso ó ascenso en plazas de oficiales de cuarta clase de la Hacienda Pública, Madrid, Mateu, 1906.Bueso, A., Recuerdos de un cenetista, Barcelona, Ariel, 1976.Burgos y Mazo, M. de, El verano de 1919 en Gobernación, Imprenta de E. Pinós-Cuenca, 1921.Calderón, F. de P. [Rico Ariza, E.] y Romero, I., Memorias de un terrorista. Novela episódica de la tragedia barcelonesa, Barcelona, [s.e.], [1924?].Carden, R. M., German Policy Toward Neutral Spain, 1914-1918, London, Routledge, 2014.Cardona, G., Los Milans del Bosch, una familia de armas tomar. Entre la revolución liberal y el franquismo, Barcelona, Edhasa, 2005.Casal Gómez, M., La Banda Negra. El origen y la actuación de los pistoleros en Barcelona (1918-1921), 2ª. Edición, Barcelona, Icaria, 1977.Calle Velasco, M. D. de la, “Sobre los orígenes del estado social en España”, Ayer, 25 (1997), pp. 127-150.D’Ors, E., “La unidad de Europa”, La Vanguardia, (1/12/1914), p. 7.Díaz Plaja, F., Francófilos y germanófilos. Los españoles en la guerra europea, Barcelona, Dopesa, 1973.Díez, P., Memorias de un anarcosindicalista de acción, Barcelona, Bellaterra, 2006.Domingo Méndez, R., “La Gran Guerra y la neutralidad española: entre la tradición historiográfica y las nuevas líneas de investigación”, Spagna Contemporanea, 34 (2008), pp. 27-44.Esculies, J., “España y la Gran Guerra. Nuevas aportaciones historiográficas”, Historia y Política, 32 (2014), pp. 47-70.Esdaile, Ch. J., La Quiebra del liberalismo, 1808-1939, Barcelona, Crítica, 2001.Foix, P., Los Archivos del terrorismo blanco. El fichero Lasarte (1910-1930), Madrid, Las Ediciones de la Piqueta, 1978.Forcadell, C., Parlamentarismo y bolchevización. El movimiento obrero español, 1914-1918, Barcelona, Crítica, 1978.Fuentes Codera, M., “El somni del retorn a l’Imperi: Eugeni d’Ors davant la Gran Guerra”, Recerques, 55 (2007), pp. 73-93.Fuentes Codera, M., “Germanófilos y neutralistas. Proyectos tradicionalistas y regeneracionistas para España (1914-1918)”, Ayer, 91/3 (2013), pp. 63-92.Fuentes Codera, M., España en la Primera Guerra Mundial. Una movilización cultural, Madrid, Akal, 2014.García Oliver, J., El Eco de los pasos, Paris/Barcelona, Ruedo Ibérico, 1978.García Sanz, F., España en la Gran Guerra, Madrid, Galaxia Gutenberg, 2014.Giráldez, E., “Brabo Portillo ¡Yo te acuso, Asesino!”, Solidaridad Obrera, 840 (5/8/1918), p. 1.Golden, L., “Les dones com avantguarda; El rebombori del pa del gener 1918”, L’Avenç (1981), pp. 45-52.Golden, L., “The women in command. The Barcelona women’s consumer war of 1918”, UCLA Historical Journal (1985), pp. 5-32.E. González Calleja y F. del Rey Reguillo, La Defensa armada contra la revolución. Una historia de las guardias cívicas en la España del siglo XX, Madrid, CSIC, 1995.González Calleja, E., La Razón de la fuerza. Orden público, subversión y violencia política en la España de la Restauración, 1875-1917, Madrid, CSIC, 1998.González Calleja, E., El Máuser y el sufragio. Orden público, subversión y violencia política en la crisis de la Restauración (1917-1931), Madrid, CSIC, 1999.González Calleja, E., (ed.), Políticas del miedo. Un balance del terrorismo en Europa, Madrid, Biblioteca Nueva, 2002.González Calleja, E., La España de Primo de Rivera. La modernización autoritaria 1923-1930, Madrid, Alianza Editorial, 2005.González Calleja, E., El laboratorio del miedo. Una historia general del terrorismo, Barcelona, Crítica, 2013.González Calleja, E. y Aubert, P., Nidos de espías. España, Francia y la Primera Guerra Mundial, Madrid, Alianza, 2014.González Calleja, E. (coord.), Anatomía de una crisis. 1917 y los españoles, Madrid, Alianza, 2017.Granados de Siles, J., “El escandaloso espionaje de Barcelona”, Solidaridad Obrera, 793 (19/6/1918), p. 1.Gual Villalbí, P., Memorias de un industrial de nuestro tiempo, Barcelona, Sociedad General de Publicaciones, [193?].León-Ignacio, J., Los años del pistolerismo. Ensayo para una guerra civil, Barcelona, Planeta, 1981.León-Ignacio, J., “Brabo Portillo, comisario y político”, Historia y vida, 181 (1983), pp. 68-73.Llates, R., 30 anys de vida catalana, Barcelona, Aedos, 1969.Madrid, F., Ocho meses y un día en el Gobierno Civil de Barcelona (confesiones y testimonios), Barcelona-Madrid, Las ediciones de la flecha, 1932.Manent, J., Records d’un sindicalista llibertari català, 1916-1943, París, Edicions Catalanes de París, 1976.Marquès, J., Història de l’organització sindical tèxtil “El Radium”, Barcelona, La Llar del Llibre, 1989.Márquez, B. y Capo, J. M., Las Juntas militares de defensa, Barcelona, Librería Sintes, 1923.Martínez Fiol, D., El catalanisme i la Gran Guerra (1914-1918). Antologia, Barcelona, La Magrana, 1988.Martínez Fiol, D. y Esculies Serrat, J., L’Assemblea de Parlamentaris de 1917 i la Catalunya rebel, Barcelona, Generalitat de Catalunya, 2017.Martínez Fiol, D. y Esculies Serrat, J., 1917. El año en que España pudo cambiar, Sevilla, Renacimiento, 2018.M.C.C., “El ‘affaire’ Brabo Portillo”, publicado en El Parlamentario y reproducido por Solidaridad Obrera, 926 (2/11/1918), p. 1.Mendoza, E., La verdad sobre el caso Savolta, Barcelona, Seix y Barral, 1975.Morales Lezcano, V., El colonialismo hispano-francés en Marruecos (1898-1927), Madrid, Siglo XXI, 1976.Navarra, A., 1914. Aliadófilos y germanófilos en la cultura española, Madrid, Cátedra, 2014.Navarra, A., Aliadòfils i germanòfils a Catalunya durant la Primera Guerra Mundial, Barcelona, Generalitat-CHCC, 2016.Nisk, “¡Inocente Brabo!”, Solidaridad Obrera, 789 (15/6/1918), p, 1.Pestaña, Á.,“A vuela pluma” y “En Libertad”, Solidaridad Obrera, 840-841 (5-6/8/1918), p. 1.Pestaña, Á., Terrorismo en Barcelona. Memorias inéditas, Barcelona, Planeta, [1979].Pradas Baena, M. A., L’anarquisme i les lluites socials a Barcelona 1918-1923. La repressió obrera i la violència, Barcelona, PAM, 2003.Pujadas, X., Marcel·lí Domingo i el marcel·linisme, [Barcelona], PAM, 1996.Roig, M., Rafael Vidiella. L’aventura de la revolució, Barcelona, Laia, 1976.Romero Salvadó, F. J., “Crisi, agonia i fi de la monarquía liberal (1914-1923)”, Segle XX. Revista catalana d’història, 1 (2008), pp. 57-82.Romero Salvadó, F. J. y Smith, A. (eds.), The Agony of Spanish Liberalism. FromRevolution to Dictatorship 1913-23, Houndmills, Basingstoke, Palgrave Macmillan, 2010.Rosenbusch, A., “Los servicios de información alemanes: sabotaje y actividad secreta”, Andalucía en la historia, 45 (2014), pp. 24-29.Rosenbusch, A., “Guerra Total en territorio neutral: Actividades alemanas en España durante la Primera Guerra Mundial”, Hispania Nova, 15 (2017), pp. 350-372.S. A., “Historia de un ‘bravo’ muy pillo”, La Campana de Gracia, 2569 (28/6/1918), p. 4.S.A., L’Esquella de la Torratxa, (12/7 y 30/8/ y 12/9/1918), pp. 447, 451, 456, 458, 568, 577 y 592.S. A., “A cada puerco le llega su San Martín” y “La muerte de Batet”, Solidaridad Obrera, 711 y 712 (9 y 10/1/1918), p. 1.S. A., Solidaridad Obrera, 713-716 (11-14/1/1918), p. 1.S. A., “Los conflictos del hambre”, Solidaridad Obrera, 717, 719-721 y 723-727 (15 y 17-19 y 21-25/1/1918), p. 1.S.A., Solidaridad Obrera, 783 y 784-786, (9-12/6/1918), p. 1.S.A., Solidaridad Obrera, 789-790, 794-795, 798 (15-16, 20-21 y 24/6/1918), p. 1.S. A., Solidaridad Obrera, 833 y 837 (28/7 y 2/8/1918), p. 1.S. A., Solidaridad Obrera, (3/7 y 12/12/1918), p. 2.S.A., “Veredicto popular”, Solidaridad Obrera, 790, 791, 793, 794, 795, 798, 799, 800, 802, 808, 809, 810, 811, 815, 816, 817, 818, 819, 820, 821, 822, 823, 825, 826, 827, 828, 829, 830, 832, 833, 834, 835, 836, 837, 838, 839 (16, 17, 19, 20, 21, 24, 25, 26, 28/6; 4, 5, 6, 7, 11, 12, 13, 14, 15, 16, 17, 18, 19, 21, 22, 23, 24, 25, 26, 28, 29, 30, 31/7; 1, 2, 3, 4/8/1918), pp. 1-3.S.A., “Envío a doña Remedios Montero de Brabo Portillo”, 871 (7/9/1918), p. 1.S.A., Solidaridad Obrera, (24, 25, 26, 27, 28 y 30/6 y 3, 6, 8, 5, 10, 12, 13 y 19/7, 4, 5, 9, 23, 24 y 26/8, 21, 24, 25, 31/10, 1, 2/11/ y 1-6, 8, 10, 11, 12, 14, 15, 20, 30 y 31/12/1918), pp. 1-4.Safont, J., Per França i Anglaterra. La I Guerra Mundial dels aliadòfils catalans, Barcelona, Acontravent, 2012.Sánchez Marín, A. L., “El Instituto de Reformas Sociales: origen, evolución y funcionamiento”, Revista Crítica de Historia de las Relaciones Laborales y de la Política Social, 8 (mayo 2014), pp. 7-28.Smith, A., “The Catalan Counter-revolutionary Coalition and the Primo de Rivera Coup, 1917–23”, European History Quaterly 37:1 (2007), pp. 7-34.Smith, A., Anarchism, revolution and reaction. Catalan labor and the crisis of the Spanish State, 1898-1923, New York, Oxford, Berghahn, 2007.Soldevilla, F., El Año político 1920, Madrid, I. de Julio Cosano, 1921.Taibo II, P. I., Que sean fuego las estrellas. Barcelona (1917-1923), Barcelona, Crítica, 2016.Tamames, R. y Casals, X., Miguel Primo de Rivera, Barcelona, Ediciones B, 2004.Tusell, J., Radiografía de un golpe de estado. El ascenso al poder del general Primo de Rivera, Madrid, Alianza, 1987.Val, R. del y Río del Val, J. del, Solidaridad Obrera, 787-788, 790, 794, 801, 805, 807, 811, 814, 818, 828, 829, 836, 970 (13, 14, 16, 20 y 27/6/, 3, 7, 10, 14, 23, 24 y 31/7/ y 1/8/ y 10/121918), p. 1.Vandellós, P., “Contra los sindicatos. Los procesos de la sindicación obrera. De actualidad”, Solidaridad Obrera, 791 (17/6/1918), p. 1.Vidiella, R., Los de ayer. Novela, Madrid-Barcelona, Nuestro Pueblo, 1938.Winston, C. M., La Clase trabajadora y la derecha en España (1900-1936), Madrid, Cátedra, 1989.Winston, C. M., “Carlist workers groups in Catalonia, 1900-1923”, en S. G. Payne (dir.), Identidad y nacionalismo en la España contemporánea: el carlismo, 1833-1975, Madrid, Actas, 1996, pp. 85-101.Wosky, Solidaridad Obrera, 791, 801 y 820, (17 y 21/6/ 10/7/1918), pp. 1 y 3.

Abstract A connected even {[}2,2s] -factor of a graph G is a connected factor with all vertices of degree i(i=2,4,\ldots ,2s) , where s\ge 1 is an integer. In this paper, we show that a \tfrac{k+1}{s+2} -tough k-tree has a connected even {[}2,2s] -factor and thereby generalize the result that a \tfrac{k+1}{3} -tough k-tree is Hamiltonian in [Hajo Broersma, Liming Xiong, and Kiyoshi Yoshimoto, Toughness and hamiltonicity in k-trees, Discrete Math. 307 (2007), 832–838].

Abstract A connected even [ 2 , 2 s ] {[}2,2s] -factor of a graph G is a connected factor with all vertices of degree i ( i = 2 , 4 , … , 2 s ) i(i=2,4,\ldots ,2s) , where s ≥ 1 s\ge 1 is an integer. In this paper, we show that a k + 1 s + 2 \tfrac{k+1}{s+2} -tough k-tree has a connected even [ 2 , 2 s ] {[}2,2s] -factor and thereby generalize the result that a k + 1 3 \tfrac{k+1}{3} -tough k-tree is Hamiltonian in [Hajo Broersma, Liming Xiong, and Kiyoshi Yoshimoto, Toughness and hamiltonicity in k-trees, Discrete Math. 307 (2007), 832–838].

Abstract Abstract 838 Eradication of minimal residual disease (MRD) during the first months of ALL treatment is associated with improved disease-free survival (DFS). We hypothesized that alemtuzumab, a humanized anti-CD52 monoclonal antibody, might be an effective, novel agent for eradication of MRD. In CALGB 10102, we tested dose escalation of alemtuzumab in sequential cohorts of CD52+ cases to a target dose of 30 mg administered SC 3 times/week for 4 weeks (12 doses) during post-remission therapy. Dose limiting toxicity (DLT) was defined as the inability to proceed with protocol treatment within 6 weeks after the last dose of alemtuzumab. Eligible patients (pts) had ≥10% lymphoblast CD52 expression at diagnosis determined in a CALGB reference laboratory. Antimicrobial prophylaxis for cytomegalovirus (CMV) and Pneumocystis carinii was mandated. The 10102 therapy consisted of 6 monthly chemotherapy modules followed by maintenance therapy for a total of 2 years (Stock et al. ASH 2005, abstr 145); 299 untreated ALL pts were eligible and enrolled from 2003–2007. We previously reported (Lozanski et al. ASH 2007, abstr 2386) that 70% were CD52+ and eligible to receive Alemtuzumab (70% of B-cell ALL; 53% of T-cell ALL; 100% of Ph+ cases). Results: Twenty-four pts in remission (CR1) received Alemtuzumab as their fourth treatment module during the Phase I portion of the study. The median age was 37 years (18-77 years); 18 (80%) had B-cell ALL; 5 (19%) had T-cell ALL. 17/24 cases had evaluable cytogenetics after central review: 5 had favorable, 8 intermediate-risk, 2 poor-risk cytogenetics (neither were Ph+), and 2 were not classifiable (miscellaneous abnormalities). Non-hematologic toxicities were mild. SC alemtuzumab was well tolerated. Grade 3-4 myelosuppression was reported during 4 weeks of alemtuzumab treatment in 4 pts; 2 pts had Grade 3-4 lymphopenia. 4 pts had DLT: subsequent treatment was delayed in 2 due to transient CMV viremia; 1 developed Staph aureus empyema; and 1 had prolonged myelosuppression but did not receive G-CSF support as recommended by the protocol. 3 pts relapsed with ALL immediately following completion of the alemtuzumab module. Serial assessment of MRD using quantitative clone-specific PCR was possible in 11/24 cases. There was a median 1-log decrease in MRD during alemtuzumab therapy in the 20 and 30 mg cohorts. However, there was a 2-log rise during alemtuzumab therapy in one pt who relapsed 6 weeks later. Pharmacokinetic analysis revealed rising alemtuzumab serum levels during treatment in all dose cohorts, and levels were still detectable in some pts 10 weeks after completing alemtuzumab. During subsequent post-remission therapy, 8 pts developed CMV viremia, 2 had Herpes simplex infections, and 3 had Herpes zoster reactivation. There was not a significant correlation between serum alemtuzumab level and change in MRD or risk of viral infection. The median follow-up time for the 14 surviving pts is 51 months (49-54 months). Median DFS is 53 months (95% CI, 39 – not reached); median overall survival is 55 months (95% CI, 42- not reached). Conclusions: CD52 is expressed in the majority of adult ALL cases. Addition of alemtuzumab to front-line therapy is feasible and provides reduction in MRD, but is associated with viral infections. Dose escalation of alemtuzmab was not associated with DLT. Based on these results, the 30 mg dose of alemtuzumab was explored in an additional 70 patients in the Phase II portion of the study. The encouraging DFS results reported here require confirmation from longer follow-up of the larger Phase II cohort of patients. Disclosures: Stock: Genzyme: Research Funding. Off Label Use: The testing of alemtuzumab for treatment of ALL in adults. Lozanski:Genzyme: Research Funding. Vij:CELGENE: Honoraria, Research Funding, Speakers Bureau. Powell:Antisoma: Research Funding. Sher:invivoscribe: Employment. Richards:Genzyme: Employment. Sung:genzyme: Employment.

Abstract Hepatic iron content is increased in patients with PCT and phlebotomy-induced iron depletion corrects the clinical and biochemical phenotype. Approximately 20 percent of patients with PCT are homozygous for mutations of the hemochromatosis gene (HFE) but the cause of iron overload in most patients is unknown. Hepatic URO-D activity is markedly reduced when PCT is manifest and URO-D activity improves following iron depletion. Most patients with PCT have no mutations of the URO-D gene (sporadic PCT) but approximately 1/3 of cases are heterozygous for URO-D mutations (familial PCT) (BLOOD. 2000; 95:1565–71). To determine the mechanism by which iron overload causes PCT we created 3 murine models: Mice with one null allele of Uro-d (Uro-d+/−) and 2 null Hfe alleles (Hfe−/ −) (PNAS.2001; 98:259–64); Uro-d+/− mice treated with iron-dextran, aminolevulinic acid (ALA) and polychlorinated biphenyls (PCB) and; wild type mice treated with iron, ALA and PCB (J. Biochem. Mol. Toxicol.2001; 15:287–93). All models accumulate uroporphyrin in the liver and all have hepatic URO-D activity of 25% or less but Western blots revealed no change in URO-D protein. An iron deficient diet prevented the PCT phenotype in Uro-d+/−, Hfe−/ − animals and greatly attenuated the phenotype in animals treated with ALA and PCB (Env. Toxicol. Pharmacol.2005; 417–23). Liver homogenates from all porphyric models were heat denatured and clarified by centrifugation. The supernatants inhibited the activity of purified recombinant human URO-D (rhURO-D) by approximately 60%. The inhibitory activity was further purified by solid phase extraction and HPLC. The fraction containing the inhibitory activity did not fluoresce. Mass spectrometry of this fraction demonstrated a dominant peak with a mass of 835 Da and an absorption maximum of approximately 500 nM, the optical signature of a porphomethene. An inhibitor with identical properties was generated by partially oxidizing the uroporphyrinogen (837 Da) substrate of URO-D under UV light. Full oxidation of either the inhibitor purified from porphyric mouse liver or from partially oxidized, enzymatically generated uroporphyrinogen (either isomer I or III) yielded a compound with a mass of 831 Da and an absorption maximum of approximately 400 nM, indicating that the fully oxidized inhibitor was uroporphyrin. Tandem mass spectrometry of the 835 Da inhibitor indicated that the inhibitor was a tetrapyrrole. Collectively these data indicate that the inhibitor is a porphomethene derived form uroporphyrinogen through oxidation of a single bridge carbon between adjacent pyrrole rings. An inhibitor of rhURO-D was also identified in heat-denatured cytosol from liver biopsy samples obtained from four humans with PCT. We conclude that clinical expression of PCT requires an iron dependant oxidation reaction that generates a porphomethene inhibitor of URO-D.

Objetivo: describir la experiencia en la práctica de Histerectomía Laparoscópica Total (HLT) con énfasis en las complicaciones presentadas.Metodología: el presente es un estudio de cohorte histórica en el cual se incluyeron las pacientes que fueron intervenidas entre diciembre de 2002 y abril de 2008 y en quienes, además, se completó al menos 90% de la información requerida en un formulario prediseñado. Durante la investigación, se evaluaron las características sociodemográficas, las indicaciones de cirugía, el porcentaje de laparoconversión y las causas de la misma, el tiempo quirúrgico, la pérdida sanguínea estimada, el tiempo de hospitalización, el número de dosis de analgésicos requeridos, los días de incapacidad y las complicaciones intraoperatorias y postoperatorias.Resultados: en total se incluyeron 837 pacientes, cuya edad promedio fue 42,7 años. 83,8% de las mujeres eran ASA I (American Society of Anesthesiologists) y la principal enfermedad de base fue la hipertensión arterial (9,9%). En 822 de ellas, el procedimiento se llevó a cabo por laparoscopia mientras que 15 (1,7%) requirieron laparoconversión. Las indicaciones más frecuentes para la cirugía fueron miomatosis (43,8%) y hemorragia uterina anormal (36,1%). Adicional a esto, el tiempo quirúrgico promedio fue 85,9 minutos, la pérdida sanguínea media fue de 60,6 mL y la tasa total decomplicaciones llegó a ser 12,5%; de lacuales,3,1% lo constituyeron complicaciones mayores.Conclusiones: la tasa de complicaciones de la histerectomía laparoscópica total es similar a la informada en la literatura y está acompañada de una estancia hospitalaria breve.

Introduction. Intussusception is a common abdominal emergency in infants and children. Ultrasonography and barium enema are very useful in diagnosis and treatment of this condition. The aim of the study was to assess the accuracy of ultrasound-guided saline enema for intussusception and to determine if some factors may improve the outcome of this technique. Material and methods. Intussusception was diagnosed in 63 patients at the Clinic of Pediatric Surgery in Novi Sad. The study period was divided into two 2-year phases: phase I, from 2001 through 2002, and phase II, from 2003 through 2004. During phase I, besides barium enema and fluoroscopy, we started using ultrasonography and ultrasound-guided hydrostatic saline enema in the diagnosis and reduction of intussusception. In phase II, this method of reduction was routinely used in all cases. Our technique of ultrasonic reduction was similar to the conventional hydrostatic barium reduction, except the reservoir was higher than that of barium, analgosedation ot patients was performed and in case of difficult and prolonged reduction, gentle manual pressure to the abdomen at right lower quadrant was used. Results. In phase I the diagnostic accuracy of ultrasonography in detecting intussusception was 53.8% , and 100% in phase II. The success rate of ultrasound-guided saline enema was 55.5% in phase I, and 83.8% in phase II. Only 6 patients (16.2%) underwent operative manual reduction of intussusception in phase II. There were no cases with bowel gangrene or perforations in both groups. Conclusions. Ultrasonography is a useful screening tool in the diagnosis of intussusception. The main advantage of hydrostatic reduction with ultrasound guidance is avoidance of ionizing radiation. The success rate of this method of reduction may be increased with an integrated team approach to the management and with modifications of the technique.

LBA5000 Background: The epidermal growth factor receptor (EGFR) has been found to be overexpressed in 55-98% of advanced epithelial ovarian cancer. This trial evaluated the efficacy of maintenance erlotinib, an EGFR tyrosine kinase inhibitor, after first-line chemotherapy. Methods: Eligible patients (pts) had high-risk FIGO stage I or stage II-IV epithelial ovarian, peritoneal or fallopian tube cancer and were not selected for EGFR expression. All patients underwent first line therapy (6-9 cycles of 3-weekly platinum-based chemotherapy (CT)) and showed no signs of progression at the end of CT. Patients were randomised to maintenance erlotinib 150 mg daily for 2 years or observation. Primary endpoint was progression-free survival (PFS) by RECIST in combination with GCIG CA125 criteria. The final design provided 80% power to detect a PFS hazard ratio (HR) of 0.80 with 2-sided log-rank test at 5% after 632 events in 830 patients. Stratifications factors were stage, institution, age, response to and type of first-line CT. Immunohistochemistry (IHC) and FISH for EGFR, and EGFR mutation analyses were performed in 330 patients. The study was registered as NCT00263822 and EudraCT number 2004-004333-34. Results: Between Oct 2005 and Feb 2008, 835 pts were randomised by 125 institutions from 10 countries. The most important baseline characteristics, PFS and OS are summarized in the table. Median follow-up was 51 months. 25% of the patients stopped erlotinib due to side effects (of these 67% due to rash). The predictive value of IHC and FISH for EGFR, and EGFR mutations are being evaluated and will be presented at the meeting. Conclusions: In the overall study populationmaintenance erlotinib after first-line treatment in ovarian cancer did not improve progression-free or overall survival. [Table: see text]

Abstract Background IMU-838 (vidofludimus calcium) is a well-tolerated and orally available small molecule inhibitor of dihydroorotate dehydrogenase (DHODH) and is currently in phase 2 clinical development for ulcerative colitis (UC). Here, we investigated the effect of IMU-838 on different immune cell subsets and analysed the mechanism of action in more detail in T cells. Methods The effect of IMU-838 on regulatory macrophages (Mregs) was investigated by adding IMU-838 or anti-TNFα antibodies (infliximab, adalimumab), alone or in combination, in a mixed lymphocyte reaction assay, determining Mregs (CD206+CD14+) by FACS analysis. To investigate the effect of IMU-838 on human T and B cells, PBMC were stimulated with PHA (48h) or Oligonucleotide 2006-PTO (70h), respectively. An affinity-dependent effect of IMU-838 was assessed on CD8 T cells from OT-I and OT-III mice, containing a high and a low affinity T cell receptor (TCR), respectively, for OVA257-264 peptide. These cells were stimulated with ovalbumin (OVA) peptide loaded splenocytes or anti-CD3/anti-CD28 for 3 days. Oxidative phosphorylation (OXPHOS) and glycolysis in murine T cells was investigated by the Seahorse/Agilent technique in murine CD4 and CD8 T cells activated with anti-CD3/anti-CD28 with or without IMU-838. Results IMU-838 slightly induced Mregs, but strongly and dose-dependently decreased TNFα and IL-6 secretion. Anti-TNFα antibodies alone strongly induced Mregs, but also increased IL-6 levels. When IMU-838 was added, Mregs induction was even higher, and IL-6 was reduced. Besides reducing proinflammatory cytokines secreted by macrophages, IMU-838 also inhibits proliferation of activated B and T cells, as well as inflammatory T cell cytokine secretion, IL-17A, IL-17F and IFNγ, and increased apoptosis up to 3-fold compared to vehicle control. By investigating IMU-838’s role on affinity related activity status of T cells, it was shown that IMU-838 strongly inhibited cell proliferation in the peptide stimulated high affinity, but not in the low affinity, CD8 T cells. Peptide stimulated high affinity T cells show an upregulation of OXPHOS and glycolysis pathways, which are involved in the generation of the cell’s energy supply, compared to low affinity cells. IMU-838 strongly inhibited OXPHOS and glycolysis in both CD4 and CD8 T cells. Conclusion IMU-838 reduces the proinflammatory immune cell response by inducing Mregs, reducing pro-inflammatory cytokine secretion and reducing immune cell proliferation. DHODH is only important in cells that received a strong stimulus and are highly metabolically active. Therefore, IMU-838 will only specifically target these cells and will still allow for a normal immune response, representing a huge safety advantage for treatment of IBD patients.

“Candidatus phytoplasma asteris” and related strains (i.e., aster yellows group 16SrI) have been associated with diseases of numerous plant species worldwide. Symptoms of aster yellows (AY) have been reported on rapeseed/canola (Brassica napus and B. rapa) crops in Saskatchewan (SK) and Manitoba, Canada since 1953 (2). Symptoms generally include stunting, virescence, leaf yellowing or purpling, phyllody, and formation of bladder-like siliques. A total of 120 mature B. rapa cv. AC Sunbeam plants exhibiting AY symptoms were collected in commercial fields near Medstead, SK during 2003 and 2004 (one field per year). As described previously (4), total genomic DNA was extracted from leaf, stem, roots, and seeds collected from the 120 plants, from seeds from the seed lots sown in 2003 and 2004, and from leaf and stem tissue of 20 greenhouse-grown plants from each seed lot. The latter DNA samples were assayed for phytoplasma DNA by a nested polymerase chain reaction (PCR) assay incorporating phytoplasma universal 16S rRNA primer pairs P1/P6 (1) followed by R16R2/R16F2 (4). Seed samples analyzed from the 2003 and 2004 seed lots and tissues of the 40 greenhouse-grown plants all tested negative for phytoplasma DNA using this assay. Leaf, stem, and/or root tissues of all plants collected in the field in 2003 (60 plants) and 2004 (60 plants) and 71.1% (315 of 443) of seed samples (five seeds per sample) tested positive for the presence of phytoplasma DNA, as evidenced by the presence of an expected band of 1.2 kb on the gels after the second amplification with primers R16R2/R16F2. Nested PCR products from plant samples collected in 2003 were cloned, sequenced, and compared with phytoplasma sequences archived in the GenBank nucleotide database. On this basis, phytoplasmas detected in plants or their seeds collected in 2003 were found to be most similar (98.8%) to CHRY (Accession No. AY180956), a 16SrI-A subgroup strain, or were most similar (98.9%) to isolate 99UW89 (Accession no. AF268407), a known 16SrI-B subgroup strain. Sequences of phytoplasmas detected in plants or their seeds in 2004 were obtained by direct sequencing of rRNA products amplified from samples using PCR incorporating primer pairs P1/P6 and P4/P7 (3). Analysis of sequence data revealed that phytoplasmas in these plants were all most similar (99.5%) to AY-WB (Accession no. AY389828), a 16SrI-A subgroup member. The nucleotide sequences have been deposited with GenBank under Accession nos. DQ404346, DQ404347, and DQ411470. To our knowledge, this is the first report of 16SrI-A and 16SrI-B subgroup phytoplasmas infecting plants and seed of B. rapa in Saskatchewan. References: (1) I.-M. Lee et al. Phytopathology, 83:834, 1993. (2) W. E. Sackston. Can. Plant Dis. Surv. 33:41, 1953. (3) L. B. Sharmila et al. J. Plant Biochem. Biotech. 13:1, 2004. (4) E. Tanne et al. Phytopathology, 91:741, 2001.

In der vorliegenden Arbeit wird erstmals darauf hingewiesen, dass sich im Fidelio viele Gedankenstränge manifestieren, die nicht nur dem damaligen Zeitgeist verhaftet sind, sondern auch Rudimente der näheren und weiteren Vergangenheit darstellen. Die Autorin gliedert ihre Studie in drei Teile mit einem Anhang, in dem die originalsprachlichen Texte von Léonore und Fidelio wiedergegeben werden. Hinzuweisen ist in diesem Teil besonders auf die polnische Übersetzung von 1814, die damit der Forschung erstmals leicht zugänglich gemacht wird.

Nationalism: Past as Prologue began as a single volume being compiled by Ad Akande, a scholar from South Africa, who proposed it to me as co-author about two years ago. The original idea was to examine how the damaging roots of nationalism have been corroding political systems around the world, and creating dangerous obstacles for necessary international cooperation. Since I (Bruce E. Johansen) has written profusely about climate change (global warming, a.k.a. infrared forcing), I suggested a concerted effort in that direction. This is a worldwide existential threat that affects every living thing on Earth. It often compounds upon itself, so delays in reducing emissions of fossil fuels are shortening the amount of time remaining to eliminate the use of fossil fuels to preserve a livable planet. Nationalism often impedes solutions to this problem (among many others), as nations place their singular needs above the common good. Our initial proposal got around, and abstracts on many subjects arrived. Within a few weeks, we had enough good material for a 100,000-word book. The book then fattened to two moderate volumes and then to four two very hefty tomes. We tried several different titles as good submissions swelled. We also discovered that our best contributors were experts in their fields, which ranged the world. We settled on three stand-alone books:” 1/ nationalism and racial justice. Our first volume grew as the growth of Black Lives Matter following the brutal killing of George Floyd ignited protests over police brutality and other issues during 2020, following the police assassination of Floyd in Minneapolis. It is estimated that more people took part in protests of police brutality during the summer of 2020 than any other series of marches in United States history. This includes upheavals during the 1960s over racial issues and against the war in Southeast Asia (notably Vietnam). We choose a volume on racism because it is one of nationalism’s main motive forces. This volume provides a worldwide array of work on nationalism’s growth in various countries, usually by authors residing in them, or in the United States with ethnic ties to the nation being examined, often recent immigrants to the United States from them. Our roster of contributors comprises a small United Nations of insightful, well-written research and commentary from Indonesia, New Zealand, Australia, China, India, South Africa, France, Portugal, Estonia, Hungary, Russia, Poland, Kazakhstan, Georgia, and the United States. Volume 2 (this one) describes and analyzes nationalism, by country, around the world, except for the United States; and 3/material directly related to President Donald Trump, and the United States. The first volume is under consideration at the Texas A & M University Press. The other two are under contract to Nova Science Publishers (which includes social sciences). These three volumes may be used individually or as a set. Environmental material is taken up in appropriate places in each of the three books. * * * * * What became the United States of America has been strongly nationalist since the English of present-day Massachusetts and Jamestown first hit North America’s eastern shores. The country propelled itself across North America with the self-serving ideology of “manifest destiny” for four centuries before Donald Trump came along. Anyone who believes that a Trumpian affection for deportation of “illegals” is a new thing ought to take a look at immigration and deportation statistics in Adam Goodman’s The Deportation Machine: America’s Long History of Deporting Immigrants (Princeton University Press, 2020). Between 1920 and 2018, the United States deported 56.3 million people, compared with 51.7 million who were granted legal immigration status during the same dates. Nearly nine of ten deportees were Mexican (Nolan, 2020, 83). This kind of nationalism, has become an assassin of democracy as well as an impediment to solving global problems. Paul Krugman wrote in the New York Times (2019:A-25): that “In their 2018 book, How Democracies Die, the political scientists Steven Levitsky and Daniel Ziblatt documented how this process has played out in many countries, from Vladimir Putin’s Russia, to Recep Erdogan’s Turkey, to Viktor Orban’s Hungary. Add to these India’s Narendra Modi, China’s Xi Jinping, and the United States’ Donald Trump, among others. Bit by bit, the guardrails of democracy have been torn down, as institutions meant to serve the public became tools of ruling parties and self-serving ideologies, weaponized to punish and intimidate opposition parties’ opponents. On paper, these countries are still democracies; in practice, they have become one-party regimes….And it’s happening here [the United States] as we speak. If you are not worried about the future of American democracy, you aren’t paying attention” (Krugmam, 2019, A-25). We are reminded continuously that the late Carl Sagan, one of our most insightful scientific public intellectuals, had an interesting theory about highly developed civilizations. Given the number of stars and planets that must exist in the vast reaches of the universe, he said, there must be other highly developed and organized forms of life. Distance may keep us from making physical contact, but Sagan said that another reason we may never be on speaking terms with another intelligent race is (judging from our own example) could be their penchant for destroying themselves in relatively short order after reaching technological complexity. This book’s chapters, introduction, and conclusion examine the worldwide rise of partisan nationalism and the damage it has wrought on the worldwide pursuit of solutions for issues requiring worldwide scope, such scientific co-operation public health and others, mixing analysis of both. We use both historical description and analysis. This analysis concludes with a description of why we must avoid the isolating nature of nationalism that isolates people and encourages separation if we are to deal with issues of world-wide concern, and to maintain a sustainable, survivable Earth, placing the dominant political movement of our time against the Earth’s existential crises. Our contributors, all experts in their fields, each have assumed responsibility for a country, or two if they are related. This work entwines themes of worldwide concern with the political growth of nationalism because leaders with such a worldview are disinclined to co-operate internationally at a time when nations must find ways to solve common problems, such as the climate crisis. Inability to cooperate at this stage may doom everyone, eventually, to an overheated, stormy future plagued by droughts and deluges portending shortages of food and other essential commodities, meanwhile destroying large coastal urban areas because of rising sea levels. Future historians may look back at our time and wonder why as well as how our world succumbed to isolating nationalism at a time when time was so short for cooperative intervention which is crucial for survival of a sustainable earth. Pride in language and culture is salubrious to individuals’ sense of history and identity. Excess nationalism that prevents international co-operation on harmful worldwide maladies is quite another. As Pope Francis has pointed out: For all of our connectivity due to expansion of social media, ability to communicate can breed contempt as well as mutual trust. “For all our hyper-connectivity,” said Francis, “We witnessed a fragmentation that made it more difficult to resolve problems that affect us all” (Horowitz, 2020, A-12). The pope’s encyclical, titled “Brothers All,” also said: “The forces of myopic, extremist, resentful, and aggressive nationalism are on the rise.” The pope’s document also advocates support for migrants, as well as resistance to nationalist and tribal populism. Francis broadened his critique to the role of market capitalism, as well as nationalism has failed the peoples of the world when they need co-operation and solidarity in the face of the world-wide corona virus pandemic. Humankind needs to unite into “a new sense of the human family [Fratelli Tutti, “Brothers All”], that rejects war at all costs” (Pope, 2020, 6-A). Our journey takes us first to Russia, with the able eye and honed expertise of Richard D. Anderson, Jr. who teaches as UCLA and publishes on the subject of his chapter: “Putin, Russian identity, and Russia’s conduct at home and abroad.” Readers should find Dr. Anderson’s analysis fascinating because Vladimir Putin, the singular leader of Russian foreign and domestic policy these days (and perhaps for the rest of his life, given how malleable Russia’s Constitution has become) may be a short man physically, but has high ambitions. One of these involves restoring the old Russian (and Soviet) empire, which would involve re-subjugating a number of nations that broke off as the old order dissolved about 30 years ago. President (shall we say czar?) Putin also has international ambitions, notably by destabilizing the United States, where election meddling has become a specialty. The sight of Putin and U.S. president Donald Trump, two very rich men (Putin $70-$200 billion; Trump $2.5 billion), nuzzling in friendship would probably set Thomas Jefferson and Vladimir Lenin spinning in their graves. The road of history can take some unanticipated twists and turns. Consider Poland, from which we have an expert native analysis in chapter 2, Bartosz Hlebowicz, who is a Polish anthropologist and journalist. His piece is titled “Lawless and Unjust: How to Quickly Make Your Own Country a Puppet State Run by a Group of Hoodlums – the Hopeless Case of Poland (2015–2020).” When I visited Poland to teach and lecture twice between 2006 and 2008, most people seemed to be walking on air induced by freedom to conduct their own affairs to an unusual degree for a state usually squeezed between nationalists in Germany and Russia. What did the Poles then do in a couple of decades? Read Hlebowicz’ chapter and decide. It certainly isn’t soft-bellied liberalism. In Chapter 3, with Bruce E. Johansen, we visit China’s western provinces, the lands of Tibet as well as the Uighurs and other Muslims in the Xinjiang region, who would most assuredly resent being characterized as being possessed by the Chinese of the Han to the east. As a student of Native American history, I had never before thought of the Tibetans and Uighurs as Native peoples struggling against the Independence-minded peoples of a land that is called an adjunct of China on most of our maps. The random act of sitting next to a young woman on an Air India flight out of Hyderabad, bound for New Delhi taught me that the Tibetans had something to share with the Lakota, the Iroquois, and hundreds of other Native American states and nations in North America. Active resistance to Chinese rule lasted into the mid-nineteenth century, and continues today in a subversive manner, even in song, as I learned in 2018 when I acted as a foreign adjudicator on a Ph.D. dissertation by a Tibetan student at the University of Madras (in what is now in a city called Chennai), in southwestern India on resistance in song during Tibet’s recent history. Tibet is one of very few places on Earth where a young dissident can get shot to death for singing a song that troubles China’s Quest for Lebensraum. The situation in Xinjiang region, where close to a million Muslims have been interned in “reeducation” camps surrounded with brick walls and barbed wire. They sing, too. Come with us and hear the music. Back to Europe now, in Chapter 4, to Portugal and Spain, we find a break in the general pattern of nationalism. Portugal has been more progressive governmentally than most. Spain varies from a liberal majority to military coups, a pattern which has been exported to Latin America. A situation such as this can make use of the term “populism” problematic, because general usage in our time usually ties the word into a right-wing connotative straightjacket. “Populism” can be used to describe progressive (left-wing) insurgencies as well. José Pinto, who is native to Portugal and also researches and writes in Spanish as well as English, in “Populism in Portugal and Spain: a Real Neighbourhood?” provides insight into these historical paradoxes. Hungary shares some historical inclinations with Poland (above). Both emerged from Soviet dominance in an air of developing freedom and multicultural diversity after the Berlin Wall fell and the Soviet Union collapsed. Then, gradually at first, right wing-forces began to tighten up, stripping structures supporting popular freedom, from the courts, mass media, and other institutions. In Chapter 5, Bernard Tamas, in “From Youth Movement to Right-Liberal Wing Authoritarianism: The Rise of Fidesz and the Decline of Hungarian Democracy” puts the renewed growth of political and social repression into a context of worldwide nationalism. Tamas, an associate professor of political science at Valdosta State University, has been a postdoctoral fellow at Harvard University and a Fulbright scholar at the Central European University in Budapest, Hungary. His books include From Dissident to Party Politics: The Struggle for Democracy in Post-Communist Hungary (2007). Bear in mind that not everyone shares Orbán’s vision of what will make this nation great, again. On graffiti-covered walls in Budapest, Runes (traditional Hungarian script) has been found that read “Orbán is a motherfucker” (Mikanowski, 2019, 58). Also in Europe, in Chapter 6, Professor Ronan Le Coadic, of the University of Rennes, Rennes, France, in “Is There a Revival of French Nationalism?” Stating this title in the form of a question is quite appropriate because France’s nationalistic shift has built and ebbed several times during the last few decades. For a time after 2000, it came close to assuming the role of a substantial minority, only to ebb after that. In 2017, the candidate of the National Front reached the second round of the French presidential election. This was the second time this nationalist party reached the second round of the presidential election in the history of the Fifth Republic. In 2002, however, Jean-Marie Le Pen had only obtained 17.79% of the votes, while fifteen years later his daughter, Marine Le Pen, almost doubled her father's record, reaching 33.90% of the votes cast. Moreover, in the 2019 European elections, re-named Rassemblement National obtained the largest number of votes of all French political formations and can therefore boast of being "the leading party in France.” The brutality of oppressive nationalism may be expressed in personal relationships, such as child abuse. While Indonesia and Aotearoa [the Maoris’ name for New Zealand] hold very different ranks in the United Nations Human Development Programme assessments, where Indonesia is classified as a medium development country and Aotearoa New Zealand as a very high development country. In Chapter 7, “Domestic Violence Against Women in Indonesia and Aotearoa New Zealand: Making Sense of Differences and Similarities” co-authors, in Chapter 8, Mandy Morgan and Dr. Elli N. Hayati, from New Zealand and Indonesia respectively, found that despite their socio-economic differences, one in three women in each country experience physical or sexual intimate partner violence over their lifetime. In this chapter ther authors aim to deepen understandings of domestic violence through discussion of the socio-economic and demographic characteristics of theit countries to address domestic violence alongside studies of women’s attitudes to gender norms and experiences of intimate partner violence. One of the most surprising and upsetting scholarly journeys that a North American student may take involves Adolf Hitler’s comments on oppression of American Indians and Blacks as he imagined the construction of the Nazi state, a genesis of nationalism that is all but unknown in the United States of America, traced in this volume (Chapter 8) by co-editor Johansen. Beginning in Mein Kampf, during the 1920s, Hitler explicitly used the westward expansion of the United States across North America as a model and justification for Nazi conquest and anticipated colonization by Germans of what the Nazis called the “wild East” – the Slavic nations of Poland, the Baltic states, Ukraine, and Russia, most of which were under control of the Soviet Union. The Volga River (in Russia) was styled by Hitler as the Germans’ Mississippi, and covered wagons were readied for the German “manifest destiny” of imprisoning, eradicating, and replacing peoples the Nazis deemed inferior, all with direct references to events in North America during the previous century. At the same time, with no sense of contradiction, the Nazis partook of a long-standing German romanticism of Native Americans. One of Goebbels’ less propitious schemes was to confer honorary Aryan status on Native American tribes, in the hope that they would rise up against their oppressors. U.S. racial attitudes were “evidence [to the Nazis] that America was evolving in the right direction, despite its specious rhetoric about equality.” Ming Xie, originally from Beijing, in the People’s Republic of China, in Chapter 9, “News Coverage and Public Perceptions of the Social Credit System in China,” writes that The State Council of China in 2014 announced “that a nationwide social credit system would be established” in China. “Under this system, individuals, private companies, social organizations, and governmental agencies are assigned a score which will be calculated based on their trustworthiness and daily actions such as transaction history, professional conduct, obedience to law, corruption, tax evasion, and academic plagiarism.” The “nationalism” in this case is that of the state over the individual. China has 1.4 billion people; this system takes their measure for the purpose of state control. Once fully operational, control will be more subtle. People who are subject to it, through modern technology (most often smart phones) will prompt many people to self-censor. Orwell, modernized, might write: “Your smart phone is watching you.” Ming Xie holds two Ph.Ds, one in Public Administration from University of Nebraska at Omaha and another in Cultural Anthropology from the Chinese Academy of Social Sciences, Beijing, where she also worked for more than 10 years at a national think tank in the same institution. While there she summarized news from non-Chinese sources for senior members of the Chinese Communist Party. Ming is presently an assistant professor at the Department of Political Science and Criminal Justice, West Texas A&M University. In Chapter 10, analyzing native peoples and nationhood, Barbara Alice Mann, Professor of Honours at the University of Toledo, in “Divide, et Impera: The Self-Genocide Game” details ways in which European-American invaders deprive the conquered of their sense of nationhood as part of a subjugation system that amounts to genocide, rubbing out their languages and cultures -- and ultimately forcing the native peoples to assimilate on their own, for survival in a culture that is foreign to them. Mann is one of Native American Studies’ most acute critics of conquests’ contradictions, and an author who retrieves Native history with a powerful sense of voice and purpose, having authored roughly a dozen books and numerous book chapters, among many other works, who has traveled around the world lecturing and publishing on many subjects. Nalanda Roy and S. Mae Pedron in Chapter 11, “Understanding the Face of Humanity: The Rohingya Genocide.” describe one of the largest forced migrations in the history of the human race, the removal of 700,000 to 800,000 Muslims from Buddhist Myanmar to Bangladesh, which itself is already one of the most crowded and impoverished nations on Earth. With about 150 million people packed into an area the size of Nebraska and Iowa (population less than a tenth that of Bangladesh, a country that is losing land steadily to rising sea levels and erosion of the Ganges river delta. The Rohingyas’ refugee camp has been squeezed onto a gigantic, eroding, muddy slope that contains nearly no vegetation. However, Bangladesh is majority Muslim, so while the Rohingya may starve, they won’t be shot to death by marauding armies. Both authors of this exquisite (and excruciating) account teach at Georgia Southern University in Savannah, Georgia, Roy as an associate professor of International Studies and Asian politics, and Pedron as a graduate student; Roy originally hails from very eastern India, close to both Myanmar and Bangladesh, so he has special insight into the context of one of the most brutal genocides of our time, or any other. This is our case describing the problems that nationalism has and will pose for the sustainability of the Earth as our little blue-and-green orb becomes more crowded over time. The old ways, in which national arguments often end in devastating wars, are obsolete, given that the Earth and all the people, plants, and other animals that it sustains are faced with the existential threat of a climate crisis that within two centuries, more or less, will flood large parts of coastal cities, and endanger many species of plants and animals. To survive, we must listen to the Earth, and observe her travails, because they are increasingly our own.

Neste livro são apresentados resultados de trabalhos científicos aplicados à grande área de Engenharia. De abordagem objetiva, a obra se mostra de grande relevância para graduandos, alunos de pós-graduação, docentes e profissionais. Os capítulos estão agrupados em duas seções: i) materiais; ii) águas continentais e oceânicas. Pelo capítulo um é apresentado o desenvolvimento de uma metodologia para obter-se reprodutibilidade da área superficial de um eletrodo de estanho durante o estudo do crescimento de óxidos de estanho. A reprodutibilidade da área superficial pode ser comprovada pela reprodutibilidade das densidades de carga anódicas dos voltamogramas anódicos a 50 mVs-1 posteriores a cada tratamento. Por meio do capítulo dois é analisada a substituição de parte do carvão mineral, utilizado em siderúrgicas, por biomassa. Entre os grandes desafios do setor estão a produção de aço a preços competitivos e a substituição de parte do carvão mineral utilizado por biomassa. A biomassa é considera neutra em emissões de CO2, devido a captura do mesmo durante o processo de fotossíntese, o que a torna atraente para seu uso nos processos siderúrgicos. Além disso, o seu uso pode gerar redução de custos, principalmente se for considerado os rejeitos do agronegócio que não possuem um alto valor agregado. Neste contexto, por este capítulo serão mostradas algumas possíveis utilizações de biomassa nos processos siderúrgicos através de estudos que vem sendo realizado no tema e aplicações na indústria. Será possível notar que o uso de biomassa é uma alternativa viável a curto prazo para atender as crescentes restrições ambientais atuais. Através do capítulo três é analisado o crescimento voltamétrico de óxido de estanho em solução tampão fosfato, pH 8,7. Medidas elipsométricas ex-situ foram realizadas para determinar a espessura dos óxidos crescidos. A partir desses resultados, o volume do filme por unidade de carga, Vf, foi calculado para diferentes densidades de carga. As medidas elipsométricas mostram que filmes de óxido de estanho crescidos a 2 mVs-1 são menos densos para valores de espessura 3,37 nm, tendo Vf próximo a 1,70 x 10-4 cm3C-1. Para valores mais altos de espessura (11,0 – 12,4 nm) os filmes se tornam mais densos tendo Vf próximo a 0,5 x 10-4 cm3C-1. No caso de 100 mVs-1 os filmes apresentam o mesmo comportamento, tendo Vf próximo de 3,74 x 10-4 cm3.C-1 para espessura de 4,56 nm e Vf próximo de 1,32 x 10-4 cm3.C-1 para espessura de 7,42 nm. Imagens de Microscopia de Força Atômica mostraram que a morfologia muda e a rugosidade dos filmes aumenta com o aumento da espessura e do potencial final da voltametria. O capítulo quatro trata do Nitreto cúbico de boro (cBN), material imprescindível para usinagem com alta precisão e alta velocidade de APRESENTAÇÃO materiais ferrosos como aço. O cBN é recomendado para trabalhos sob condições severas, tais como corte intermitente, em que dureza deve estar associada com tenacidade para evitar a quebra. Na síntese do cBN, são aplicados, basicamente, dois tipos de catalisadores: nitreto de magnésio e magnésio. Cada qual oferece diferentes possibilidades, tais como maiores valores de profundidade de corte ou menor nível de rugosidade superficial. Este capítulo contribui para uma melhor compreensão da manipulação dos parâmetros aplicados no regime de síntese deste elemento e, favorecendo o desenvolvimento da tecnologia de sua produção. Por meio do capítulo cinco é avaliada a aplicação de separação magnética de alta intensidade no beneficiamento de itabiritos pobres. Na rota de processo avaliada (separação magnética + flotação), a etapa de separação magnética executa a função de pré-concentração e deslamagem. O teor de SiO2 no concentrado foi de 1,46% (menor que o teor objetivo de 2,00%). As recuperações mássica e metalúrgica obtidas com a rota separação magnética + flotação foram maiores em termos absolutos 3,3% e 4,4%, respectivamente. Através do capítulo seis é realizada a otimização de injeção de poliamida PA66 com 50% GF usando o método Taguchi. O estudo se justifica pela necessidade crescente de materiais mais leves e de maior produtividade em substituição às ligas metálicas, o que demanda o constante desenvolvimento de compósitos poliméricos e eficazes processos de fabricação. Como resposta do estudo, mediu-se a resistência máxima de tração (RTmáx), numa poliamida 66 com carga de 50% de fibra de vidro, Grivory GV-5H®. Fez-se uso da metodologia ANOVA para indentificar-se os fatores de maior significância para o processo. A melhor resistência máxima de tração obtida de 242,6 N/m2, mostrou-se como uma opção na substituição à aplicações de ligas metálicas de alumínio. A melhor resultado se obteve com a temperatura de processamento em 270°C, o fluxo volumétrico de 83 cm³/s, a pressão de recalque de 300 bar, a contrapressão de 10 bar, velocidade da rosca de 50 min-1 e o tempo de recalque com valor de 5 s. As porcentagens de contribuição encontradas foram pressão de recalque com contribuição de 61%, seguido da temperatura de processamento, com contribuição de 17% e em terceiro, o fluxo volumétrico com contribuição de 12%. A instalação de grandes equipamentos submarinos em águas profundas apresenta uma série de desafios. O capítulo sete trata da análise de estabilidade hidrodinâmica de Manifolds submarinos durante a instalação pelo método pendular. O presente capítulo racionaliza tal método e, além disso, considera sistemas para evitar o capotamento, durante um momento crítico do método que é o início da descida, apresentando uma modelagem matemática fenomenológica a partir de casos similares. A etapa de validação foi realizada pela análise comparativa entre a modelagem proposta e resultados de testes experimentais realizados com modelos físicos. Com a confirmação da aderência dos resultados numéricos com os experimentos, esta abordagem se confirma como uma ferramenta de engenharia para dimensionamento dos equipamentos submarinos instalados pelo Método Pendular para que sejam direcionalmente estáveis. Por meio do capítulo oito são apresentados os resultados da simulação da distribuição espacial das ondas geradas pela ação de ventos severos sobre o reservatório da barragem de Salto Caxias, no rio Iguaçu, estado do Paraná. Os ventos severos foram estimados através da análise de frequência regional para várias estações anemométricas do Instituto Meteorológico do Paraná (SIMEPAR) para o período de 1998 a 2005. As alturas de ondas foram estimadas pelo método paramétrico SMB, que usa como dados de entrada o fetch e a velocidade do vento. O método SMB foi aplicado pelo modelo computacional ONDACAD. Os testes estatísticos indicaram que a distribuição de Wakeby foi a mais robusta para as séries curtas de ventos horários máximos anuais, produzindo estimativas de ventos severos que variaram entre 25,7 ms-1 (tempo de retorno de Tr=10 anos) a 50,9 ms-1 (Tr=100 anos). O estudo presta grande contribuição à compreensão da quantificação das alturas de ondas geradas por ventos severos neste importante reservatório do estado do Paraná. Pelo capítulo nove é apresentada uma análise comparativa bidimensional entre alturas de ondas resultantes da aplicação dos modelos paramétricos MARQUES e JONSWAP ao reservatório da Usina Hidrelétrica de Itaipu Binacional, localizado no Rio Paraná entre o Brasil e o Paraguai. Os campos de vento uniforme relacionados a períodos de recorrência de 10, 20, 50 e 100 anos foram obtidos pelos registros realizados pelo Sistema Meteorológico do Paraná (SIMEPAR). Através da utilização do modelo ONDACAD foram determinados os campos de fetch e a transformação em campos de ondas pela utilização dos modelos paramétricos MARQUES e JONSWAP. Ao proceder a análise constatou-se que, ao majorar os resultados do modelo JONSWAP em 78% chega-se aos resultados bidimensionais gerados pelo modelo Marques. Esta condição foi verificada para situações de ventos extremos, ou seja, superiores a 20ms-1 e corpos hídricos que possuem fetch máximo da ordem de 10 quilômetros. O estudo contribui para a compreensão da distribuição das magnitudes das alturas de ondas neste reservatório de grande importância no âmbito da América do Sul, de grande utilidade para estudos relacionados, por exemplo, a erosões marginais, ecossistemas aquáticos continentais, psicultura por tanques-rede, quantificação de gases de efeito estufa devido à ressuspensão de sedimentos devido a propagação de ondas.

Neste livro são apresentados resultados de trabalhos científicos aplicados à grande área de Engenharia. De abordagem objetiva, a obra se mostra de grande relevância para graduandos, alunos de pós-graduação, docentes e profissionais. Os capítulos estão agrupados em duas seções: i) materiais; ii) águas continentais e oceânicas. Pelo capítulo um é apresentado o desenvolvimento de uma metodologia para obter-se reprodutibilidade da área superficial de um eletrodo de estanho durante o estudo do crescimento de óxidos de estanho. A reprodutibilidade da área superficial pode ser comprovada pela reprodutibilidade das densidades de carga anódicas dos voltamogramas anódicos a 50 mVs-1 posteriores a cada tratamento. Por meio do capítulo dois é analisada a substituição de parte do carvão mineral, utilizado em siderúrgicas, por biomassa. Entre os grandes desafios do setor estão a produção de aço a preços competitivos e a substituição de parte do carvão mineral utilizado por biomassa. A biomassa é considera neutra em emissões de CO2, devido a captura do mesmo durante o processo de fotossíntese, o que a torna atraente para seu uso nos processos siderúrgicos. Além disso, o seu uso pode gerar redução de custos, principalmente se for considerado os rejeitos do agronegócio que não possuem um alto valor agregado. Neste contexto, por este capítulo serão mostradas algumas possíveis utilizações de biomassa nos processos siderúrgicos através de estudos que vem sendo realizado no tema e aplicações na indústria. Será possível notar que o uso de biomassa é uma alternativa viável a curto prazo para atender as crescentes restrições ambientais atuais. Através do capítulo três é analisado o crescimento voltamétrico de óxido de estanho em solução tampão fosfato, pH 8,7. Medidas elipsométricas ex-situ foram realizadas para determinar a espessura dos óxidos crescidos. A partir desses resultados, o volume do filme por unidade de carga, Vf, foi calculado para diferentes densidades de carga. As medidas elipsométricas mostram que filmes de óxido de estanho crescidos a 2 mVs-1 são menos densos para valores de espessura 3,37 nm, tendo Vf próximo a 1,70 x 10-4 cm3C-1. Para valores mais altos de espessura (11,0 – 12,4 nm) os filmes se tornam mais densos tendo Vf próximo a 0,5 x 10-4 cm3C-1. No caso de 100 mVs-1 os filmes apresentam o mesmo comportamento, tendo Vf próximo de 3,74 x 10-4 cm3.C-1 para espessura de 4,56 nm e Vf próximo de 1,32 x 10-4 cm3.C-1 para espessura de 7,42 nm. Imagens de Microscopia de Força Atômica mostraram que a morfologia muda e a rugosidade dos filmes aumenta com o aumento da espessura e do potencial final da voltametria. O capítulo quatro trata do Nitreto cúbico de boro (cBN), material imprescindível para usinagem com alta precisão e alta velocidade de APRESENTAÇÃO materiais ferrosos como aço. O cBN é recomendado para trabalhos sob condições severas, tais como corte intermitente, em que dureza deve estar associada com tenacidade para evitar a quebra. Na síntese do cBN, são aplicados, basicamente, dois tipos de catalisadores: nitreto de magnésio e magnésio. Cada qual oferece diferentes possibilidades, tais como maiores valores de profundidade de corte ou menor nível de rugosidade superficial. Este capítulo contribui para uma melhor compreensão da manipulação dos parâmetros aplicados no regime de síntese deste elemento e, favorecendo o desenvolvimento da tecnologia de sua produção. Por meio do capítulo cinco é avaliada a aplicação de separação magnética de alta intensidade no beneficiamento de itabiritos pobres. Na rota de processo avaliada (separação magnética + flotação), a etapa de separação magnética executa a função de pré-concentração e deslamagem. O teor de SiO2 no concentrado foi de 1,46% (menor que o teor objetivo de 2,00%). As recuperações mássica e metalúrgica obtidas com a rota separação magnética + flotação foram maiores em termos absolutos 3,3% e 4,4%, respectivamente. Através do capítulo seis é realizada a otimização de injeção de poliamida PA66 com 50% GF usando o método Taguchi. O estudo se justifica pela necessidade crescente de materiais mais leves e de maior produtividade em substituição às ligas metálicas, o que demanda o constante desenvolvimento de compósitos poliméricos e eficazes processos de fabricação. Como resposta do estudo, mediu-se a resistência máxima de tração (RTmáx), numa poliamida 66 com carga de 50% de fibra de vidro, Grivory GV-5H®. Fez-se uso da metodologia ANOVA para indentificar-se os fatores de maior significância para o processo. A melhor resistência máxima de tração obtida de 242,6 N/m2, mostrou-se como uma opção na substituição à aplicações de ligas metálicas de alumínio. A melhor resultado se obteve com a temperatura de processamento em 270°C, o fluxo volumétrico de 83 cm³/s, a pressão de recalque de 300 bar, a contrapressão de 10 bar, velocidade da rosca de 50 min-1 e o tempo de recalque com valor de 5 s. As porcentagens de contribuição encontradas foram pressão de recalque com contribuição de 61%, seguido da temperatura de processamento, com contribuição de 17% e em terceiro, o fluxo volumétrico com contribuição de 12%. A instalação de grandes equipamentos submarinos em águas profundas apresenta uma série de desafios. O capítulo sete trata da análise de estabilidade hidrodinâmica de Manifolds submarinos durante a instalação pelo método pendular. O presente capítulo racionaliza tal método e, além disso, considera sistemas para evitar o capotamento, durante um momento crítico do método que é o início da descida, apresentando uma modelagem matemática fenomenológica a partir de casos similares. A etapa de validação foi realizada pela análise comparativa entre a modelagem proposta e resultados de testes experimentais realizados com modelos físicos. Com a confirmação da aderência dos resultados numéricos com os experimentos, esta abordagem se confirma como uma ferramenta de engenharia para dimensionamento dos equipamentos submarinos instalados pelo Método Pendular para que sejam direcionalmente estáveis. Por meio do capítulo oito são apresentados os resultados da simulação da distribuição espacial das ondas geradas pela ação de ventos severos sobre o reservatório da barragem de Salto Caxias, no rio Iguaçu, estado do Paraná. Os ventos severos foram estimados através da análise de frequência regional para várias estações anemométricas do Instituto Meteorológico do Paraná (SIMEPAR) para o período de 1998 a 2005. As alturas de ondas foram estimadas pelo método paramétrico SMB, que usa como dados de entrada o fetch e a velocidade do vento. O método SMB foi aplicado pelo modelo computacional ONDACAD. Os testes estatísticos indicaram que a distribuição de Wakeby foi a mais robusta para as séries curtas de ventos horários máximos anuais, produzindo estimativas de ventos severos que variaram entre 25,7 ms-1 (tempo de retorno de Tr=10 anos) a 50,9 ms-1 (Tr=100 anos). O estudo presta grande contribuição à compreensão da quantificação das alturas de ondas geradas por ventos severos neste importante reservatório do estado do Paraná. Pelo capítulo nove é apresentada uma análise comparativa bidimensional entre alturas de ondas resultantes da aplicação dos modelos paramétricos MARQUES e JONSWAP ao reservatório da Usina Hidrelétrica de Itaipu Binacional, localizado no Rio Paraná entre o Brasil e o Paraguai. Os campos de vento uniforme relacionados a períodos de recorrência de 10, 20, 50 e 100 anos foram obtidos pelos registros realizados pelo Sistema Meteorológico do Paraná (SIMEPAR). Através da utilização do modelo ONDACAD foram determinados os campos de fetch e a transformação em campos de ondas pela utilização dos modelos paramétricos MARQUES e JONSWAP. Ao proceder a análise constatou-se que, ao majorar os resultados do modelo JONSWAP em 78% chega-se aos resultados bidimensionais gerados pelo modelo Marques. Esta condição foi verificada para situações de ventos extremos, ou seja, superiores a 20ms-1 e corpos hídricos que possuem fetch máximo da ordem de 10 quilômetros. O estudo contribui para a compreensão da distribuição das magnitudes das alturas de ondas neste reservatório de grande importância no âmbito da América do Sul, de grande utilidade para estudos relacionados, por exemplo, a erosões marginais, ecossistemas aquáticos continentais, psicultura por tanques-rede, quantificação de gases de efeito estufa devido à ressuspensão de sedimentos devido a propagação de ondas.

Abstract The coffee variety 'Lempira', released in Honduras in 1998, was classified 100% resistant to races I and II of coffee rust identified by Portugal's Centre for Research into Coffee Rusts (Centro de Investigação das Ferrugens do Cafeeiro) (CIFC) in 1997. However, since 2007, the disease has been reported in seed foundation plots and producer farms, the most recent epidemic report being in April 2016 in Vegas de Jalan, Juticalpa Olancho, affecting 210 ha. Since this variety constitutes 45% of the cultivated area under coffee in the country, there is a need to identify the virulence genes of the new strain and to determine the resistance and susceptibility of other cultivated varieties. For these purposes, mass samples of rust were inoculated on leaf discs of the differential clones 1343/269, 110/5, 147/1, 152/3, 33/1, 419/20, 832/1 and 832/2, together with 87/1, 1006/10, 420/10 and 420/2 from the Federal University of Vicosa, as well as on the two main cultivated resistant varieties ('Parainema' and 'IHCAFE- 90'), and seven promising genotypes, under controlled temperature conditions and relative humidity. After 20-60 days of inoculation, seven virulence genes were identified (v1, v2, v4, v5, v6, v7, v9), of which v1, v4, v6, v7 and v9 had not been reported in Honduras previously. It is inferred that this rust population arose by recombination of race v5 with v6, v7 or v9. Races with 3, 4, 5, 6 or 7 virulence determinants were identified as the most complex and aggressive strains described but they lacked the v3 and v8 determinants. In addition, it was found that 'Parainema', 'H27', 'T5296-170', 'Central American', 'Pacamara yellow' and 'Anacafe-14' are resistant because they possess the SH8 gene, absent from 'Lempira'. 'IHCAFE-90' and 'Obatá' showed 20% susceptibility, and 'Ruiru 11' was susceptible. The results reveal the diversity of rust virulence genes in Honduras and emphasize the importance of the SH3 and SH8 genes as sources of resistance.

<em>Abstract.</em>—In 2003, the Georgia Department of Natural Resources and the National Park Service initiated a 5-year Shoal Bass <em>Micropterus cataractae</em> stocking program below Morgan Falls Dam in the Chattahoochee River, Georgia with a goal of restoring population abundance to historic levels and to provide further sportfishing opportunities. Shoal Bass were marked with oxytetracyline (OTC) and stocked as juveniles at one of two size-classes (Phase I [~25 mm total length] and Phase II [~60 mm total length]) in spring (April–June) each year (2003–2007). Contribution to the adult population was evaluated by collecting adult Shoal Bass with boat electrofishing from 2007 to 2011 and viewing their otoliths for the presence of an OTC mark. Stocked Shoal Bass dominated the total sample of adult fish collected (60%), and most of these fish (83%) were stocked at the larger Phase-II size-class. Based on results from multiple regression modeling, stocked age-3 Shoal Bass catch per unit effort was positively related to mean size at stocking and spring water temperatures. Total mortality of Shoal Bass in this population was low (20%) with increased longevity (14 years) and slow growth rates. Overall, the 5-year Shoal Bass stocking program was successful in increasing Shoal Bass abundance in the Chattahoochee River below Morgan Falls Dam.

This chapter discusses the law on contractual obligations. On Exit Day, and unless any further legislative provision is made, the provisions of EU law set out in the Rome I Regulation, Regulation 593/2008, will be retained as the law of the United Kingdom. The adjustments necessary to allow the Rome I Regulation to operate as English private international law are made by the Law Applicable to Contractual Obligations and Non-Contractual Obligations (Amendment etc) (EU Exit) Regulations 2019, SI 2019 No 834: these adjustments are of no substantial importance. It follows that it is possible to refer in this chapter to the Rome I Regulation without needing to draw attention to its status as EU legislation (as it was prior to Exit Day) or as retained EU legislation (as it is on and after Exit Day).

Gliomas are the most common neuroepithelial brain tumors, different by various biological tissue types and prognosis. They could be graded with four levels according to the 2007 WHO classification. The emergence of non-invasive histological and molecular diagnostics for nervous system neoplasms can revolutionize the efficacy and safety of medical care and radically reduce healthcare costs. Our pilot study aimed to evaluate the diagnostic accuracy of deep learning (DL) in subtyping gliomas by WHO grades (I–IV) based on preoperative magnetic resonance imaging (MRI) from Burdenko Neurosurgery Center’s database. A total of 707 MRI studies was included. A “3D classification” approach predicting tumor type for the entire patient’s MRI data showed the best result (accuracy = 83%, ROC AUC = 0.95), consistent with that of other authors who used different methodologies. Our preliminary results proved the separability of MR T1 axial images with contrast enhancement by WHO grade using DL.

Giornale degli Scavi A,VI,6 (May 1912–Mar. 1929): 545 (15–18 Apr. 1928). A,VI,7 (Apr. 1929–Dec. 1935): 260 (18 Dec. 1932); 263 (23. Dec 1932); 264–5 (24 Dec. 1932); 266 (27 Dec. 1932); 267 (28 Dec. 1932). Elia 1934: 276–7. The upper levels of the volcanic deposit of this unit were excavated in April 1928. The excavators reported mixed deposit with many roof tiles and iron grates from the upper-storey windows. The ground-level rooms were not excavated until December 1932, after the excavation of the Casa del Menandro. Dimensions: l.: 165 mm (GdSc). Description: Lamp with double nozzle and handle surmounted with crescent. Discus decorated in relief with an eagle and a hare. Present location: destroyed in bombing during Second World War (inv. no. 5230). Discussion: similar type of lamp to cat. no. 831 but slightly larger. Dimensions: 130 mm × 130 mm × 50 mm (GdSc). Description: rectangular marble base, modulated. Present location: unknown, not inventoried at time of excavation. Discussion: Comparable size to cat. no. 57. Possibly in the Casa del Fabbro Supplement: see cat. no. 147. Dimensions: 160 mm × 180 mm × 50 mm (GdSc). Description: rectangular marble base, modulated. Present location: unknown, not inventoried at time of excavation. Discussion: comparable in size to cat. no. 57. Dimensions: i. h.: 320 mm; diam.: 230 mm; ii. h.: 300 mm; diam.: 230 mm; iii. h.: 300 mm; diam.: 200 mm (GdSc). Description: three cylindrical marble supports with simply modulated bases. Present location: unknown, not inventoried at time of excavation. Discussion: Proportionately rather short and wide for furniture supports but rather tall and narrow for column drums. Probably bases similar to those in the Casa del Menandro Supplement: see cat. nos. 188, 192–3. Dimensions: 330 mm × 250 mm × 130 mm (GdSc). Description: small plinth with roughly worked borders (width: c.70 mm) on all four sides, and plain surfaces. Present location: in 2001, Casa del Fabbro, room 1 (inv. no. 57616). Discussion: possibly the base for relief statuary such as a herm (see e.g. Seiler 1992: fig. 547–8).

PH46A, a new chemical entity developed by our group, has shown potent anti-inflammatory activities through various pre-preclinical studies. The aim of this work was to develop and validate a sensitive and robust LC-MS/MS analytical method to determine the levels of PH46 in human plasma, urine and faeces. The linearity (0.5–500 ng/mL for plasma/urine, and 10–2000 ng/g for human faeces), accuracy (within 100 ± 15% for plasma/urine or 100 ± 20% for faeces), precision (≤ 15% CV for plasma/urine or ≤ 20% CV for faeces) and the method’s specificity were demonstrated to be acceptable. No significant matrix effects or carry-over was observed for PH46 and IStd, and the recovery was consistent. About 10- and 100-fold dilutions in control matrix were found not to affect the assays’ performance. PH46 was proven to be stable: at room temperature for >24 hrs in plasma through 3 freeze-thaw cycles, at –20°C for 83 days in plasma/32 days in urine/33 days in faeces, and at –80°C for 154 days in plasma/33 days in faeces. The re-injection reproducibility of PH46 in matrix extracts was at least 239 hrs at 4°C in plasma/25 days in urine/6.5 days in faeces. This method was successfully applied to the pharmacokinetic evaluation of the Phase I clinical studies.

The disused sealed radioactive sources including orphan sources in Lebanon, along with the growing industry of sealed radioactive sources in medical, industrial and research fields have posed a serious problem for authorities as well as users due to the lack of a national store for disused radioactive sources. Assistance from the International Atomic Energy Agency (IAEA) was requested to condition and store disused radium needles and tubes present at two facilities. The mission took place on July 25, 2001 and was organized by the IAEA in cooperation with the Lebanese Atomic Energy Commission (LAEC). Other disused radioactive sources were kept in the facilities till a safer and securer solution is provided; however orphan sources, found mainly during export control, were brought and stored temporarily in LAEC. The necessity of a safe and secure store became a must. Prior to October 2005, there was no clear legal basis for establishing such store for disused radioactive sources, until the ministerial decree no 15512 dated October 19, 2005 (related to the implementation of decree-law no 105/83) was issued which clearly stated that “The LAEC shall, in cooperation with the Ministry of Public Health, establish a practical mechanism for safe disposal of radioactive waste”. Following this, the work on inventory of disused sealed sources along with collecting orphan sources and placing them temporarily in LAEC was legally supported. Moreover, several missions were planned to repatriate category I and II sources, one of which was completed specifically in August 2009; other missions are being worked on. In 2008, a national technical cooperation project with the IAEA was launched. Under the Technical Cooperation (TC) project with reference number LEB3002, the project was entitled “Assistance in the establishment of a safe temporary national storage at the LAECfor orphan sources and radioactive waste” which cycle is 2009–2011. Under this project, a national store for radioactive sources in the third basement of LAEC is being established. The area is being reconstructed currently and will be equipped when ready under LEB3002 project. Along with this, a system for sealed disused sources management has been prepared, part of which is applied now and the rest will be applied upon the establishment of the store. This paper will cover the inventory collection process, the study for the establishment of this store, the present and prospective waste management system, and the waste acceptance criteria.

Introduction: Stress through long-term physical aggression (distress) strongly influences the chorion - component of the gingival mucosa. To track these changes, I have discussed a number of parameters and performed statistical significance on the obtained results. I discussed the nuclear area as the nucleus represents the vital center of the cell, and all biological processes of the cell are under the control of the nucleus. The new environment created by the presence of the fixed dental prosthesis represents a non-physiological environment for humans and a real aggression (stress) on the oro-facial biosystem. Material and methods: The histological research has been carried out on a number of 83 fragments of human gingival mucosa, taken from patients wearing fixed single and multidental prostheses who were under my observation in my private dental practice during 2002-2008. The research was coordinated by Professor Mehedinti Teofil from the Faculty of General Medicine, Ovidius University Constanta (Romania). Results: The obtained quantitative data have been tabulated and statistically analyzed through the Student-Fisher method. Conclusion: Pluridental fixed prosthesis produce changes in the gingival epithelium, epithelial field, as well as on the inflammatory cells and the number of capillaries.

Esta conferencia presentó la importancia de las fuentes de financiamiento, disponibles a nivel nacional e internacional, para el desarrollo de la investigación científica en Panamá. El contenido de la presentación se centró en describir: (1) datos de contexto, (2) acciones en marcha y (3) algunas reflexiones. En cuanto a los datos de contexto internacional, se inició presentado la definición de investigación científica y desarrollo (I+D) dentro del marco del Manual de Frascati (séptima edición, año 2015). A continuación, se presentaron las cifras del gasto mundial en I+D reportadas en el “Informe de la UNESCO sobre la Ciencia: hacia 2030” y su rápido crecimiento por encima del porcentaje de la economía mundial, con una tendencia global que se mantiene hasta la actualidad. Adicionalmente, de acuerdo con dicho informe, los investigadores representan aproximadamente un 0.1% del total de la población mundial. Con este escenario de gasto y de disponibilidad de recurso humano, la investigación ha logrado grandes avances. Entre éstos se destacan los aproximadamente 2.5 millones de artículos en revistas científicas y técnicas, por año (según datos del Banco Mundial). A continuación, se describió el contexto de I+D para Panamá, presentando indicadores tales como la inversión nacional expresada en porcentaje con respecto al PIB, la cantidad de investigadores por millón de habitantes y los aspectos de formación de recurso humano e infraestructura. También se presentaron las tendencias de publicación de la comunidad científica, categorizadas por áreas de conocimiento, así como las cantidades (crecientes) de artículos científicos desde el año 2000 hasta la fecha. En cuanto a las acciones de I+D en marcha, la ponencia presentó avances significativos en Panamá, especialmente en la última década. Se presentaron datos relativos a la comunidad científica panameña, la misma que – entre otros apoyos – se ha visto fortalecida por las numerosas adjudicaciones y proyectos que han derivado del apoyo de la Secretaría Nacional de Ciencia, Tecnología e Innovación (SENACYT), así como también de fuentes internacionales. La ponencia continuó con la descripción de los esfuerzos desarrollados en el campo de I+D, publicaciones, proyectos tangibles y escenarios científicos en Panamá. Entre otros aspectos, se hizo relación a las 83 convocatorias públicas (2004 a 2019) lanzadas por la SENACYT, con al menos 567 proyectos de I+D desarrollados, para fines de fortalecer el sistema en Panamá. A continuación, se realizó también una descripción de las fuentes nacionales e internacionales de financiamiento. En esta sección se realizó la observación de que, desde ya varios años atrás, los financiamientos se hicieron disponibles (y siguen siéndolo) para todas las áreas y disciplinas de conocimiento, en su más amplia concepción. En el cierre de esta conferencia, se presentaron algunas reflexiones las mismas que están encaminadas a fortalecer la ciencia en Panamá, así como a promover el desarrollo y bienestar de la sociedad. En ese sentido, se sugirió, entre otros aspectos, lo siguiente: • Continuar los esfuerzos y la campaña para promover una mayor asignación de fondos del Estado hacia las actividades de I+D. El aumento de la inversión pública es una tarea de todos. • Dada la alta variabilidad de los datos de los indicadores nacionales e internacionales sobre I+D, se recomendó continuar con el trabajo de homologar procesos, definiciones, conteos y periodos de registro. • Alinear mejor el ecosistema de investigación – innovación – educación superior, con estos tres elementos que ofrecen grandes ventajas de colaboración. • Continuar el fortalecimiento de las acciones para retener localmente el capital humano formado en el exterior (ejemplos: el Programa de Inserción de Becarios, Convocatorias de Repatriación, estímulos a la movilidad nacional/internacional, etc.). • Promover de manera efectiva la aplicación de incentivos fiscales por el desarrollo de actividades de I+D+i en las entidades en Panamá. • Ampliar la aplicación del modelo universidad – empresa – Estado, que, si bien ha mostrado avances, debe fortalecerse. • Promocionar la colaboración entre actores del sector empresarial y el sector académico, con evidentes y permanentes sinergias. • La ponencia cerró con una recomendación a todos los presentes, quienes en su calidad de nuevos investigadores deben sumarse al motor de hacer ciencia, tecnología e innovación en Panamá.

In the unsustainable development of commodity production and resource consumption, designers are both part of the root of the problem and the agents of its solution. Education institutions and teaching plans bear a profound moral responsibility to improve designers’ ability to create a sustainable future. This chapter goes deep into the design education curriculum to explore a design process model that can be specifically applied to the field of care design.Education for sustainable development has become the main concern of environmental education since the 1990s (United Nations 1992). David W. Orr calls for an education system shift: ‘This crisis cannot be solved by the same kind of education that helped create the problems. Against the test of sustainability, our ideas, theories, sciences, humanities, social sciences, pedagogy, and educational institutions have not measured up’ (1992, p. 83). The UN Decade of Education for Sustainable Development (2005–2014) highlighted the key role of Education for Sustainable Development (ESD), aiming at ‘integrating the principles and practices of sustainable development into all aspects of education and learning, to encourage changes in knowledge, values and attitudes with the vision of enabling a more sustainable and just society for all’ (UNESCO, 2005, p.9). It fundamentally mobilized education to create relevant teaching rationales, teaching methods and learning content.The evolution of design for sustainability has been advanced ESD in higher education institutions and has created a wide array of teaching methods and tools, such as Service Design (Miso, 2020), Design Futuring (Fry, 2009), Transition Design (Jones, 2014), Systemic Design (Irwin, 2015), Design for Behaviour Change (Bhamra & Dewberry, 2007) and Ecology of Care (Coxon, 2017). The continuous improvement of sustainable design education helps designers to conceive a number of different conceptual solutions as a whole, and to take into consideration the wide array of impacts that their decisions have on people, the environment and the economy. However, the problem in curriculum education is that its focus is more on the designer’s sustainable achievements, rather than the designer's sustainable awareness and behavior changes. Strengthen the correlation between designers’sustainability awareness and design results would be appreciated.East China University of Science and Technology (ECUST) is a comprehensive university with a strong background in science and engineering. The fundamental design course teaching at the School of Art Design and Media has provided me with excellent research opportunities. In this context, I could integrate the care-oriented sustainable design course into the curriculum system and conduct research directly. I noticed that sustainable design is a special and independent concept rarely mentioned in existing design courses. As expected from traditional courses, design courses focus on creating visually compelling and fully functional works. Although some ‘green’ design projects are sometimes carried out, in most cases green design courseworks focus on finding solutions in terms of principles, technology, materials, etc., and finally propose a small product design concept without considering the whole systemof thought at the basis of design. Also, most part of the courses are devoted to the introduction of the double diamond model that guides the design process, even though it does not make full use of the scientific nature of the design process itself. Sometimes, design research is separated from design results. I am interested in reshaping the way designers think about sustainability in the field of traditional design education, by considering all the different impacts of design decisions on people, the environment and the economy.By understanding the nature of care, I intend to develop a design process model and teaching tools from the perspective of care, which can be extrapolated as a care-oriented, sustainable design education course. The design process can be seen as a learning process which provides deeper information about sustainability challenges and opportunities by influencing students’ design thinking and design activity. On the one hand, the design process model could build a clear teaching idea for teachers. On the other hand, it could raise students’ awareness of caring, and transform this consciousness into specific design schemes, which can provide insight into problems and propose solutions from larger and more complex perspectives, thereby generating new sustainable design ideas. This newly developed design process emphasizes the role of the immediate-environment in promoting clients and products care.

Picojoule colliding-pulse mode-locked pulses are amplified in four Bethune dye cells (sulforhodamine 640) and dispersion precompensated in a grating-telescope pulse shaper, typically to 200 pulses of ~100 fs duration. They pump a two-stage parametric generator of beta-barium borate (BBO). The large effective nonlinearity and angular sensitivity of BBO permit efficient conversion to 800 nm pulses, conserving the bandwidth of the pump. A collimated beam (2 mm diameter) passes the BBO crystals (7 and 5 mm length), which is cut at 20.3° for type I phase matching. The spatial separation (30 cm) and anti parallel orientation of the optical axes suppress noncollinear phase matching. Signal and idler frequencies at 830 nm and 2450 nm are generated with an overall energy conversion efficiency of 10%. This value is expected to increase closer to degeneracy. The signal can be precompensated to 150 fs: We use it for white-light generation in a 1 cm water cell and short-pulse amplification in titanium-doped sapphire. The idler provides interesting perspectives for saturation molecular spectroscopy around 3 μm with increased time resolution.

Elena Logunova1Master of Urban Planning, Post-graduate student, 1Department of Urban Design and Planning, School of Architecture and Design, Siberian Federal University Address: 79 Svobodny pr., 660041 Krasnoyarsk, Russian Federation E-mail: ikukina@inbox.ru , el.lgnv@yandex.ruScientific adviser: Pd.D., Professor - I. V. Kukina Keywords: fringe-belt, Siberia, urban morphology, fixation lineConference topics and scale: Tools of analysis in urban morphologyThe fringe-belt concept is one of the most important concepts in urban morphology which provides a possibility to analyze existing urban layout. Urban fringe-belt phenomenon in cities of Siberia hitherto was poorly investigated. Thus, it constitutes an extremely broad research area.Phases and processes of formation, transformation and alienation in urban fringe-belts examines at the case of Krasnoyarsk from the 17th to mid 20th centuries. Krasnoyarsk was founded as a military stockaded town in 1628 during the first period of Siberia development and experienced several historical stages in the process of urban growth.Relation of changes in fringe-belts structure and political and socio-economic contexts is evidently at all periods of their physical formation. Natural fixation lines (topographic features, body of big river, and development of small river valley) and man-made fixation lines (city walls, railway corridor) influenced to the formation and evolution processes of fringe-belts and urban fabric generally. Railway was a turning point in the city expansion and contributed to overcoming of the power natural fixation line as the Yenisei river. Unlike the urban core, right bank of Krasnoyarsk formed as a linear city with specific fringe belts.Detailed analysis of Krasnoyarsk city plan indentifies several morphological units separated by fringe-belts. These fringe-belts are characterized by distinctive road network, variety of land-use units and heterogeneous forms in plan. It presents difficulties for reconstruction projects of modern city. An approach for renovation of these territories needs to depend on urban morphology methodology. ReferencesConzen M. P., Kai Gu, Whitehand J. W. R. (2012) ‘Comparing traditional urban form in China and Europe: a fringe-belt approach’ Urban Geography, 33, 1, p. 22–45.Whitehand J.W. R, Morton N. J. (2003) ‘Fringe belts and the recycling of urban land: an academic concept and planning practice’, Environment and Planning B: Planning and Design, volume 30, p.819- 839. Ünlü T. (2013) ‘Thinking about urban fringe belts: a Mediterranean perspective’, Urban Morphology 17 (1), p. 5-20.

After reading the final report of The First European Survey on Language Competences (ESLC 2011: 83), I thought it was challenging for me to write this paper, focusing on how translation can improve my students' language learning, in order to become aware of the EU terminology. On the one hand, in the Romanian educational system, both teachers' and students' frequent use of the target language (English) during lessons has positive impacts, in the sense that the more students and teachers speak the target language during lessons, the higher the score on the language testing. On the other hand, translation of texts containg EU terminology brings up two questions herein - Why becoming aware of E.U terminology? How do my students perceive the relation between translation and language learning in order to become aware of the EU terminology? I answered these questions by conducting an analysis, based on a two-fold approach: selecting texts from the Guide to Research and Innovation Strategies for Smart Specialisation (RIS3) and establishing a time frame for the students to translate the selected texts. My selection of texts from the above mentioned guide is justified: the students are enrolled in the Computer Science Program and being language learners/users, their communicative language competence and awareness of EU terminology are to be activated in the performance of the various language activities, involving reception, production, interaction or mediation (in particular, translating from English into Romanian). Nowadays, mediation plays an important role in Europe, because it provides the normal linguistic functioning at EU level and, by adopting it, learners/students are able to mediate, through translating activities, between speakers of the two languages concerned, who cannot overcome the communication barrier. Moreover, I emphasized in the paper the following: becoming aware of the EU terminology, students not only become plurilingual, more interculturally aware, but they also enhance their linguistic and cultural competences. To sum up, the analysis helped me draw a relevant conclusion: translations of texts containing EU terminology enrich the students'vocabulary, enhance their capacity for further language learning, as they already know and use terms from a specialised field (more precisely, they can cope with learning a language for specific purposes - ESP) and lead to greater openness to new cultural experiences (see also the study Translation and language learning: The role of translation in the teaching of languages in the European Union 1/2013: 27).

ЦЕЛЬ: оценить выживаемость пациентов, прооперированных по поводу адренокортикального рака (АКР). МАТЕРИАЛЫ И МЕТОДЫ: ретроспективно проанализированы результатов обследования и лечения 76 пациентов с АКР, прооперированных в стационаре КВМТ СПбГУ с 2009 по 2020 гг. С 2018 года прово- дились ежегодные телефонные контакты с пациентами с доступными контактными данными. Общая вы- живаемость вычислялась как период времени от постановки диагноза до смерти по любой причине. РЕЗУЛЬТАТЫ: в анализ включено 76 пациентов с АКР, из них 19 (25,0%) мужчин и 57 (75,0%) женщин. Соотношение женщины:мужчины составил 3:1. Схожие результаты получены по литературным дан- ным (1,5–2,5:1). Масса тела была 72 [64; 83] кг, ИМТ — 26,1 [22,9; 30,2] кг/м2. Медиана возраста составила 45 [36; 56] лет, у большинства пациентов диагноз АКР был установлен при госпитализации впервые. Пик заболеваемости в исследуемой группе приходится на третью — пятую декаду жизни, тогда как по данным литературы — в возрасте 50-60 лет. У большинства пациентов (86,8%) опухоль была выявлена на локализо- ванных стадиях (I–II), заболевание III стадии отмечено у 7 (9,2%) больных, IV стадии — у 3 (3,9%). По данным крупных многоцентровых исследований АКР I-II стадий составляет около 50%. Особенности исследуемой выборки могут быть обусловлены тем, что пациенты с III и IV стадии чаще обращались в онкологические клиники, а не в узкоспециализированный центр эндокринной хирургии. У 22% пациентов диагностирован субклинический синдром Иценко — Кушинга, 26,8% — манифестный, у 51,2% установлена гормонально неактивная опухоль, что согласуется с данными литературы. У 70 пациентов проведена адреналэктомия: у 19 (27,1%) с использованием лапаротомии, у 9 (12,9%) с применением лапароскопического доступа, у 42 (60%) с ретроперитонеальным доступом. По результатам гистологического исследования индекс Ki67 составил 15 (7; 25) %, в 9 из 54 (16,7%) случаях показатель со- ставил 5%, т.е. не превысил стандартный порог определения злокачественности для дифференциальной диагностики опухолей надпочечников. Отмечено увеличение индекса Ki67 при больших размерах опухо- ли (p = 0,051, критерий ANOVA Краскелла — Уоллиса), что, вероятно, связано с быстрым ростом опухоли при высоких значениях индекса. Дальнейшее лечение проводилось согласно актуальным на тот момент клиническим рекомендациям. Оценка общей выживаемости проведена у 50 пациентов с доступными контактными данными. Собраны данные об 11 событиях. Пятилетняя выживаемость пациентов составила порядка 70%, что превышает данные литературы. Статистически значимого влияния наличия синдрома Иценко — Кушинга, послео- перационного приема кортефа, а также хирургического доступа при операции на прогноз для пациента в ходе анализа обнаружено не было. ВЫВОДЫ: женский пол ассоциирован с АКР, что обусловлено, вероятно, секрецией эстрогенов. Примерно в половине случаев АКР является гормонально-активной опухолью с гиперкортизолизмом. Индекс Ki67 является недостаточно информативным показателем для прогноза выживаемости при АКР. Общая выживаемость в проведенном исследовании несколько выше, чем данные литературы, что мо- жет быть обусловлено более молодым возрастом выборки, а также большим количеством пациентов с I-II стадиями заболевания.

Hot deformation characteristics of forged and β-quenched Zr-1.0Sn-0.3Nb-0.3Fe-0.1Cr (N18 alloy) in the temperature range 625–950°C and in the strain rate range 0.005–5 s−1 have been studied by uniaxial compression testing of Gleeble 3500. For this study, the approach of processing maps has been adopted and their interpretation done using the Dynamic Materials Model (DMM). Based on a series of true stress-true strain curves on various temperatures and strain rates, the flow stress has been summarized and both the strain rate sensitivity index (m) and deformation activation energy (Q) have been calculated by the constitutive equations that flow stress and the relationship of Z parameter and flow stress have been established subsequently. Furthermore, the efficiency of power dissipation (⬜) given by [2m/(m+1)] and improved by Murty has been plotted as a function of temperature and strain rate to obtain different processing maps at different true strain rates ranging from 0.1–0.7. Subsequently, the microstructures of the specimens after compression testing were characterized by electron channeling contrast (ECC) imaging techniques used an FEI Nova 400 field emission gun scanning electron microscopy (FEG-SEM). The results showed that: (i) The hyperbolic sine constitutive equation can describe the flow stress behavior of zirconium alloy, and the deformation activation energy and flow stress equation were calculated under the different temperature stages which insists that the deformation mechanism is not dynamic recovery. (ii) The hot processing maps and its validation were analyzed, which indicated that the DMM theory was reliable and could be adopted as useful tool for optimizing hot workability of Zr. The optimum parameters for extrusion and hammer forging were revealed on the processing maps of 830–950°C, 0.048–2.141 s−1 and 916–950°C, 2.465–5 s−1. (iii) The microstructure of the ingot exhibits a typical lamellar Widmanstatten structure. Under the different strain rates, the grains formed by dynamic recrystallization existed normally in the central zone of the compression samples while the no uniformity of grain size increased with the increasing of strain rate. Meanwhile, due to the dynamic recrystallization as a thermal activation process, the grains size and uniformity increased with the increasing of temperature. In brief, microstructure analysis showed that continuous dynamic recrystallization and geometric dynamic recrystallization operated concurrently during the isothermal compressive deformation.

Denna rapport sammanställer information om märkningsprojekt med ål (Anguilla anguilla) utförda i sjön Ymsen. Märkningsexperimenten utfördes åren 1998–2002 samt 2012. Data över återfångster samlas in kontinuerligt, en insamling som pågår än idag (år 2023). Denna rapport innehåller data insamlad fram till och med år 2022. Syftet med rapporten är både att sammanfatta vad som har gjorts och att redogöra för vilka data som finns tillgängliga för framtida projekt. Följande märkningsprojekt har utförts i sjön: • År 1998 utfördes en mindre inledande testmärkning med PIT-tags på ålyngel, 190 märkta ålar sattes ut. • År 1999 utfördes ytterligare en testmärkning med PIT-tags, denna gång märktes 83 gulålar. • År 1999–2002 utfördes märkningsexperiment för att undersöka om strontiummärkning (Sr) fungerar för att skilja utsatt från naturligt förekommande ål. Totalt sattes 17 768 Sr-märkta ålar ut, varav 2 627 även var märkta med PIT-tags (PIT-tags användes år 1999 och 2000). Av de som både var Sr och PIT-tag märkta så har 334 återfångats (till och med 2022) och resultaten visade att strontium fungerade bra för att märka ål. • År 2004 undersökte man skarvens påverkan som predator på ål genom att söka efter PIT-tags (från märkningarna som utfördes 1999 och 2000) i en skarvkoloni. Totalt 30 PIT-tag märken återfanns i skarvkolonin. • År 2012 utfördes ett märkningsexperiment där 118 gulålar märktes med PIT-tags och Carlinmärken för att undersöka om förlust av Carlinmärken förekom. Av de 65 ålar som återfångats (till och med 2016) hade en förlorat sitt Carlinmärke. Data över utsättningar och återfångster finns lagrade på Sötvattenslaboratoriet server, och/eller i databasen ”Sötebasen” (som hanteras av Sveriges lantbruksuniversitet, institutionen för akvatiska resurser, SLU Aqua)