Bibliografias temáticas / 158/.1

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Literatura científica selecionada sobre o tema "158/.1"

Autor: Grafiati
Publicado: 25 de julho de 2024
Última modificação: 31 de julho de 2024

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Artigos de revistas sobre o assunto "158/.1"

1

Nasr, I., M. Austin e M. Tarzi. "PTU-158 Coeliac disease investigation and follow-up: Abstract PTU-158 Table 1". Gut 61, Suppl 2 (28 de maio de 2012): A250.1—A250. http://dx.doi.org/10.1136/gutjnl-2012-302514c.158.

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Clapper, Brenda, Anh-Hue T. Tu, Warren L. Simmons e Kevin Dybvig. "Bacteriophage MAV1 Is Not Associated with Virulence of Mycoplasma arthritidis". Infection and Immunity 72, n.º 12 (dezembro de 2004): 7322–25. http://dx.doi.org/10.1128/iai.72.12.7322-7325.2004.

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ABSTRACT Previous studies demonstrated that Mycoplasma arthritidis strain 158 acquired a high degree of virulence upon lysogenization with bacteriophage MAV1. In the present study, the association between MAV1 and virulence was reexamined by creating new lysogens of 158 and of a relatively avirulent mutant, strain 158-1. In the absence of lysogenization, 158 was more virulent than expected. The virulence of 158 and 158-1 did not increase upon lysogenization. A major antigenic difference between 158 and 158-1 was identified that is unrelated to MAV1 and could account for the difference in virulence.
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Clark, John R. "Pope's Epilogue to the Satires, dialogue 1, 155–158". Explicator 50, n.º 3 (abril de 1992): 144–46. http://dx.doi.org/10.1080/00144940.1992.9937936.

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BOYLE, K., M. ANDERSON e P. TURKELLAUB. "158 Characterization of cat extracts: Beyond fel d 1". Journal of Allergy and Clinical Immunology 87, n.º 1 (janeiro de 1991): 178. http://dx.doi.org/10.1016/0091-6749(91)91441-u.

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Zhang, Chunfen, Katie L. Zobeck e Zachary F. Burton. "Human RNA Polymerase II Elongation in Slow Motion: Role of the TFIIF RAP74 α1 Helix in Nucleoside Triphosphate-Driven Translocation". Molecular and Cellular Biology 25, n.º 9 (1 de maio de 2005): 3583–95. http://dx.doi.org/10.1128/mcb.25.9.3583-3595.2005.

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ABSTRACT The role of the RAP74 α1 helix of transcription factor IIF (TFIIF) in stimulating elongation by human RNA polymerase II (RNAP II) was examined using millisecond-phase transient-state kinetics. RAP74 deletion mutants RAP74(1-227), which includes an intact α1 helix, and RAP74(1-158), in which the α1 helix is deleted, were compared. Analysis of TFIIF RAP74-RAP30 complexes carrying the RAP74(1-158) deletion reveals the role of the α1 helix because this mutant has indistinguishable activity compared to TFIIF 74(W164A), which carries a critical point mutation in α1. We report adequate two-bond kinetic simulations for the reaction in the presence of TFIIF 74(1-227) + TFIIS and TFIIF 74(1-158) + TFIIS. TFIIF 74(1-158) is defective because it fails to promote forward translocation. Deletion of the RAP74 α1 helix results in increased occupancy of the backtracking, cleavage, and restart pathways at a stall position, indicating reverse translocation of the elongation complex. During elongation, TFIIF 74(1-158) fails to support detectable nucleoside triphosphate (NTP)-driven translocation from a stall position and is notably defective in supporting bond completion (NTP-driven translocation coupled to pyrophosphate release) during the processive transition between bonds.
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Editor, El. "Presentación No. 158". Realidad, revista de ciencias sociales y humanidades, n.º 158 (22 de novembro de 2021): 1–2. http://dx.doi.org/10.51378/realidad.v0i158.6428.

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Argiles, Guillem, Christiane Jungels, Rocio Garcia-Carbonero, Marc Diez Garcia, Johanna C. Bendell, Josep Tabernero, Mohamed Bekradda et al. "Phase I dose-escalation study of MCLA-158, a first-in-class bispecific antibody targeting EGFR and LGR5, in metastatic colorectal cancer (CRC)." Journal of Clinical Oncology 39, n.º 3_suppl (20 de janeiro de 2021): 62. http://dx.doi.org/10.1200/jco.2021.39.3_suppl.62.

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62 Background: The WNT and EGFR signaling pathways are oncogenic and mitogenic drivers in CRC and other cancers. MCLA-158 is an ADCC enhanced human IgG1 cLC bispecific antibody identified from functional screening of CRC patient (pt)-derived organoids (PDO). MCLA-158 exposure leads to EGFR degradation in LGR5+ cancer and exhibits potent growth inhibition of RASmut and wt CRC PDOs, while minimal inhibition is observed in non-tumoral PDOs. Blockade of metastasis initiation was seen in preclinical in vivo models. MCLA-158 also demonstrated tumor regression or stasis in esophageal squamous (6/6) and gastric adenocarcinoma (6/8) PDX models selected for LGR5 and EGFR expression. Methods: Metastatic CRC pts progressing after oxaliplatin, irinotecan and fluoropyrimidines, and EGFR monoclonal antibodies if RASwt, received MCLA-158 IV every 2 weeks (q2w; 4-week cycle) in a phase I study. Safety, efficacy (per RECIST 1.1), PK and ADA were assessed. WNT and EGFR pathway components were evaluated in tumor tissue. EGFR pathway mutations (ctDNA) and soluble EGFR (sEGFR) were assessed in blood. PDOs were derived from baseline biopsies and assessed for MCLA-158 responsiveness. Results: As of 7 September 2020, 33 pts were treated over 11 dose levels (5 to 1500 mg, flat dose). At enrollment, median age was 58 years (range 35-76), ECOG PS 0/1:22/11, and 15 pts were RASmut. Pts had a median of 3 metastatic sites (range 1-12) with a median of 4 prior lines of therapy (range 1-10). A median of 2 MCLA-158 cycles (range 1-6) were administered. No dose limiting toxicity occurred. Infusion-related reactions were the most common AEs (67% of pts), occurred mostly in cycle 1 (21/22 pts), and were manageable. Other common related AEs included rash acneiform (36%), diarrhea (15%), pyrexia (9%) and asthenia/fatigue (9%). Related AEs were mostly mild or moderate; G3 related AEs were IRRs (4 pts; 12%), diarrhea and hypophosphatemia (1 pt each). The RP2D (1500 mg) was selected based on safety, PK and receptor occupancy prediction. MCLA-158 exhibited target-mediated clearance with proportional PK from 750 mg (t1/2 ~80 h at 1500 mg). Low ADA titers were seen in 3/23 pts, with no effect on PK. Target saturation is predicted at steady state serum trough levels. No clinical responses were observed during dose escalation. No/low baseline tumor EGFR expression (0-1+ IHC) was observed in 17/30 pts and non-elevated sEGFR levels ( < 4 ng/mL) in 18/22 pts. More than 1 activating mutation in EGFR signaling pathway genes were identified in ctDNA from 10/20 pts. 1/4 PDOs had > 30% growth inhibition with MCLA-158 ex vivo. MCLA-158 activity on PDOs correlated negatively with the presence of EGFR pathway resistance-mutations. Conclusions: Dual EGFR/LRG5 blockade with MCLA-158 was well tolerated, and the RP2D was 1500 mg IV q2w. Enrollment of pts with gastric and other non-CRC cancers at the RP2D continues in the expansion phase. Clinical trial information: NCT03526835.
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Tu, A. H. T., B. Clapper, T. R. Schoeb, A. Elgavish, J. Zhang, L. Liu, H. Yu e K. Dybvig. "Association of a Major Protein Antigen of Mycoplasma arthritidis with Virulence". Infection and Immunity 73, n.º 1 (janeiro de 2005): 245–49. http://dx.doi.org/10.1128/iai.73.1.245-249.2005.

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ABSTRACT Mycoplasma arthritidis causes acute polyarthritis in rats and chronic proliferative arthritis in mice. M. arthritidis-induced arthritis serves as a model for arthritis caused by infectious agents and as a model for examining the role of the superantigen MAM (M. arthritidis T-cell mitogen) in the development of autoimmunity. M. arthritidis strain 158-1 is a spontaneous mutant of strain 158 that has a drastic reduction in virulence. We show that the mutant is missing a major antigen of 47 kDa (P47) and has acquired a protein of 67 kDa (P67). P47 and P67 partitioned into the detergent phase by extraction with Triton X-114. Coomassie blue staining of sodium dodecyl sulfate-polyacrylamide gels show that P67 is produced in abundance. Analysis of gel-purified P67 by mass spectrometry led to its identification as a lipoprotein (the open reading frame [ORF] 619 gene product) predicted from the genome sequence of M. arthritidis. PCR analysis of genomic DNA from 158 and 158-1 indicates that P47 and P67 are encoded by the same ORF 619 gene and differ only in the number of repeats in a tandem repeat region. By two-dimensional polyacrylamide gel analysis, no protein differences were detectable between 158 and 158-1 other than P47 and P67. Collectively, the data suggest that the tandem repeat region of P47 and P67 influences disease outcome.
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Ebner, Karl, Simone B. Sartori, Rita Murau, Fabian Kopel, Predrag Kalaba, Vladimir Dragačević, Johann J. Leban, Nicolas Singewald, Mario Engelmann e Gert Lubec. "The Novel Analogue of Modafinil CE-158 Protects Social Memory against Interference and Triggers the Release of Dopamine in the Nucleus Accumbens of Mice". Biomolecules 12, n.º 4 (27 de março de 2022): 506. http://dx.doi.org/10.3390/biom12040506.

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Previous studies have shown that atypical dopamine-transporter-inhibitors such as modafinil and its analogues modify behavioral and cognitive functions in rodents. Here, we tested potential promnestic effects of the novel, more dopamine-transporter selective modafinil analogue CE-158 in the social discrimination memory task in male mice. Systemic administration of CE-158 1 h before the social learning event prevented the impairment of social-recognition memory following retroactive interference 3 h after the learning session of a juvenile conspecific. This effect was dose-dependent, as mice treated with 10 mg/kg, but not with 1 mg/kg CE-158, were able to discriminate between the novel and familiar conspecific despite the presentation of an interference stimulus, both 3 h and 6 h post learning. However, when 10 mg/kg of the drug was administered after learning, CE-158 failed to prevent social memory from interference. Paralleling these behavioral effects, the systemic administration of 10 mg/kg CE-158 caused a rapid and sustained elevation of extracellular dopamine in the nucleus accumbens, a brain area where dopaminergic signaling plays a key role in learning and memory function, of freely moving mice, while 1 mg/kg was not sufficient for altering dopamine levels. Taken together, our findings suggest promnestic effects of the novel dopamine-transporter-inhibitor CE-158 in a social recognition memory test that may be in part mediated via increased dopamine-neurotransmission in the nucleus accumbens. Thus, selective-dopamine-transporter-inhibitors such as CE-158 may represent interesting drug candidates for the treatment of memory complaints observed in humans with cognitive impairments and dementia.
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Yoon, Jung-Hoon, Mi-Hwa Lee e Tae-Kwang Oh. "Porphyrobacter donghaensis sp. nov., isolated from sea water of the East Sea in Korea". International Journal of Systematic and Evolutionary Microbiology 54, n.º 6 (1 de novembro de 2004): 2231–35. http://dx.doi.org/10.1099/ijs.0.63226-0.

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Two Gram-negative, motile, non-spore-forming, bacteriochlorophyll a-containing slightly halophilic strains, SW-132T and SW-158, were isolated from sea water of the East Sea in Korea, and subjected to a polyphasic taxonomic study. The two isolates were characterized chemotaxonomically as having Q-10 as the predominant respiratory lipoquinone and major amounts of unsaturated fatty acids C18 : 1 ω7c and C17 : 1 ω6c. The DNA G+C contents of the two strains were in the range 66·8–65·9 mol%. The 16S rRNA gene sequences of strains SW-132T and SW-158 were 99·9 % (1 nt difference) similar and their mean level of DNA–DNA relatedness was 86 %. The 16S rRNA gene sequence analysis showed that strains SW-132T and SW-158 are phylogenetically closely related to Porphyrobacter species and Erythromicrobium ramosum. Similarities between the 16S rRNA gene sequences of strains SW-132T and SW-158 and the type strains of Porphyrobacter species and E. ramosum ranged from 97·8 to 99·0 %. DNA–DNA relatedness data indicated that strains SW-132T and SW-158 are members of a genomic species that is separate from the four Porphyrobacter species. On the basis of phenotypic and phylogenetic data and genetic distinctiveness, strains SW-132T (=KCTC 12229T=DSM 16220T) and SW-158 (=KCTC 12230) are classified as a novel Porphyrobacter species, for which the name Porphyrobacter donghaensis sp. nov. is proposed.
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Teses / dissertações sobre o assunto "158/.1"

1

El, Bazzal Zouhair. "La clustérisation des réseaux sans fil ad hoc : une approche efficace et performante". Mémoire, École de technologie supérieure, 2008. http://espace.etsmtl.ca/158/1/EL_BAZZAL_Zouhair.pdf.

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Un réseau sans fil Ad hoc consiste en un groupe de noeuds mobiles facilement déployables sans l'existence d'une infrastructure préexistante. Chaque noeud joue le rôle d'un hôte/routeur et utilise le canal radio comme le seul moyen de communication. Le routage classique s'appuie souvent sur une vue à plat du réseau Ad hoc et utilise un mécanisme d'inondation des paquets de contrôle afin de maintenir les routes. Cette inondation crée des problèmes d'utilisation inefficace des ressources en termes de traitement, de capacité, d'énergie et de bande passante. Aucun protocole de routage ne permet le déploiement à grande échelle du réseau Ad hoc; la raison principale est le manque d'une hiérarchie. Dans cette thèse, nous proposons de découper le réseau en clusters afin de réduire la complexité de la topologie et de bâtir un réseau mis à l'échelle. Chaque cluster comprend un chef qui joue le rôle d'un point d'accès mobile. Nous pouvons ainsi imaginer une dorsale virtuelle dynamique servant d'une part à acheminer le trafic de contrôle entre les chefs d'une manière fiable et efficace et d'autre part, de limiter l'effet des changements de topologie et des conditions des noeuds dans les clusters adjacents. Le choix du noeud-chef est sujet à plusieurs critères en termes de performances (stabilité, mobilité, énergie, capacité, etc.). Ces critères constituent des métriques à considérer dans les calculs analytiques et les simulations. Pour que les clusters puissent s'adapter dynamiquement aux changements de l'environnement, nous avons proposé un mécanisme de maintenance distribuée permettant de gérer les adhésions, les handoff des noeuds et la réélection des noeuds-chefs. Parallèlement, un modèle analytique élaboré a été proposé pour faire les estimations nécessaires des paramètres de qualité de service. Ce qui nous a également permis d'intégrer un mécanisme de contrôle d'admission sur les noeuds-chefs, permettant d'éviter les congestions et toutes les perturbations intraclusters. Ceci nous a amené à balancer la charge entre les différents clusters et d'optimiser l'utilisation des ressources du réseau ^ ^ hoc. Les résultats numériques obtenus nous ont aidés à réajuster les paramètres utilisés dans la clustérisation afin de fournir une meilleure qualité de service aux applications utilisées. Finalement, pour valider nos résultats, nous avons défini quelques paramètres utiles à l'étude des performances du modèle. Les résultats des simulations ont clairement montré le niveau de stabilité des clusters en présence de mobilité et en termes de nombre de clusters formés, nombre de ré-affiliations, nombre de transitions sur les chefs, niveau de qualité de service globale, équilibrage de charge et passage à l'échelle. Nous avons aussi remarqué une meilleure connectivité et un niveau de stabilité élevé en comparant notre modèle avec un autre de la littérature et en présence de mobilité.
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Grandner, Thomas, e Dieter Gstach. "Joint adjustment of house prices, stock prices and output towards short run equilibrium". Inst. für Volkswirtschaftstheorie und -politik, WU Vienna University of Economics and Business, 2004. http://epub.wu.ac.at/158/1/document.pdf.

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A dynamic IS-LM model including stocks and houses as additional assets will be analyzed in this paper. Providing also housing services, a major consumption item for most households, houses create an additional link between the monetary and the real sector of the economy. The adjustment path of output, house prices and stock prices after exogenous policy shocks will be derived within a rational expectation setup. This will show how different reaction patterns of asset prices are related to different elasticities of housing services demand. These general analytical results are contrasted with relevant empirical work, particularly Lastrapes [2002], leading to the identification of plausible elasticity ranges. The particular results for those shed new light upon the ongoing discussion about demand effects from real estate wealth and about determinants of house price fluctuations. (author's abstract)
Series: Department of Economics Working Paper Series
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Santos, Éverton Neves dos. "Experiências pessoais e formativas de jovens universitários no curso de Direito : Vademecum, vem comigo". Universidade Federal de Mato Grosso, 2015. http://ri.ufmt.br/handle/1/158.

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A presente pesquisa foi desenvolvida no Programa de Pós-Graduação em Educação da Universidade Federal de Mato Grosso, linha de pesquisa Organização Escolar, Formação e Práticas Pedagógicas, e investigou como os jovens universitários do Curso de Direito, na cidade de Diamantino-MT, narram suas Experiências pessoais e formativas e como estas são significadas a partir da entrada no curso. A perspectiva teórico-metodológica aproxima-se da pesquisa narrativa, conforme Clandinin e Connelly (2011), Mello (2005) e outros. Os significados foram compostos a partir de um conjunto de narrativas, produzidas pelos participantes e pelo pesquisador (notas de campo e textos de campo). Da literatura tomamos como base os estudos sobre as Experiências em Larrosa Larrosa (2002, 2004), Dewey (1994, 2008); já sobre jovens: Spósito (1997, 2005), Corrochano (2013), Dayrell (2000), Abramavoy e Esteves (2007), Abramo (1997) e outros. Em relação à Educação Jurídica: Wolkmer (1997), Warat (2000,2001), Lyra Filho (1986), Souza Júnior (1984, 1987, 2008), Streck (2004). Além de Freire (1987, 2011, 2005) e Gadamer (1997, 2002). A pesquisa abrangeu seis jovens ingressantes no Curso de Direito da Universidade do Estado de Mato GrossoUNEMAT- Campus de Diamantino. Ao reconstruir as experiências vividas, foram compostos os seguintes eixos temáticos: 1- “Vidas, Tempos e Escola: Percurso Escolar dos jovens”, no qual demonstra Experiências no/do percurso escolar, isto é as percepções dos tempos de escola; 2- “Por que Direito?: Tempos, contextos de uma escolha”, aqui subdividido em duas perspectivas: “A Família: sentidos e significados, razões de uma escolha”; “Eu vou fazer direito”: entre inspirações, status e afetos, isto é quais fatores externos de algum modo motivaram a escolha pelo Curso de Bacharelado em Direito; 3- “Jovens no Curso de Direito: Vademecum, vem comigo”, trata das Experiências que os jovens ingressos estão vivenciando no curso superior, desde a questão da identidade do “ser jovem” às reflexões da Educação Jurídica ofertada. Os resultados revelaram a complexidade da vida, do nosso tempo e das escolhas, os dilemas e as dificuldades enfrentadas no cotidiano pelos participantes. Igualmente revelam que as experiências e memórias dos jovens não seguem uma trajetória linear. As narrativas demonstram que as dificuldades da vida, o apoio, sentidos e significados da família, o status social, as inspirações, desejos, possibilidades e afetos construídos a partir e além da escola permearam as narrativas, de modo que a continuidade na formação do ser jovem e universitário perpassam as histórias contadas de um ontem, do presente e projetadas no vindouro
This research was conducted at the Graduate Program in Education at the Federal University of Mato Grosso, Research School Organisation line, Training and Pedagogical Practices, and investigated the problem of how university students of the Law School in the city of Diamantino, MT , narrate their personal experiences and training and how these are meant from entering the course. The theoretical-methodological perspective approaches the narrative research as Clandinin and Connelly (2011), Mello (2005) and others. The meanings are composed from a set of accounts, produced by the investigator and the participant (field cards and field texts). Literature take as a basis the studies on the experiences in Larrosa Larrosa (2002, 2004), Dewey (1994, 2008); already on young: Spósito (1997, 2005), Corrochano (2013), Dayrell (2000), and Abramavoy Esteves (2007), Abramo (1997) and others. Regarding the Legal Education: Wolkmer (1997), Warat (2000.2001), Lyra Filho (1986), Souza Júnior (1984, 1987, 2008), Streck (2004). In Freire (1987, 2011, 2005) and Gadamer (1997, 2002). The research covered six (6) entering young at Law Course at the State University of Mato Grosso-UNEMAT- campus DiamantinoMt. By reconstructing the experiences were the following themes compounds: 1- Experiences in / of schooling, which will bring the perceptions of school days; 2- The contexts of choice at Law Course, which subdivided the role of family, sense and meaning; "I'm going to do right": between inspirations, Status and Affections, ie external factors which somehow motivated the choice of the course of Bachelor of Law; 3- Young at Law Course : Vademecum , come with me " , deals with the experiences that young people are experiencing tickets in the upper reaches , from the question of the identity of " being young " in reflection of the Legal Education offered . The results revealed the complexity of life , of our time and choices , dilemmas and difficulties faced in daily life by the participants. Also show that the experiences and memories of young people do not follow a linear path . The stories demonstrate that the difficulties of life, support , senses and family meanings , social status , inspirations , desires, possibilities and affections constructed from and beyond the school permeated the narrative , so that the continuity of the formation of the young college permeate the stories of yesterday , present and projected into the future
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Buhrmester, Thorsten. "Zur Fehlordnung im System Li1+xMn2-yO4-d". Phd thesis, [S.l. : s.n.], 2001. http://tuprints.ulb.tu-darmstadt.de/158/1/ThorstenBuhrmester.pdf.

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Lithiummanganoxid ist bekannt als preiswertes und ungiftiges Elektrodenmaterial in sekundären Lithiumionenzellen. Das Spinellsystem (Li1+xMn2-yO4-d) kristallisiert bei Zimmertemperatur in der Raumgruppe Fd-3m. Das Zyklenverhalten dieser Substanz in einer Batterie ist von großem wirtschaftlichen Interesse bei der Produktion von Batteriezellen. Es wurde gezeigt, dass zusätzlich eingebautes Lithium die Zyklenstabilität signifikant erhöht. In dieser Arbeit wurde Spinellmaterial mit unterschiedlichen Lithiumüberschußgehalten hergestellt und durch Röntgen- und Neutronenpulverbeugung charakterisiert. Die Röntgenabsorption (EXAFS) wurde zur detaillierten Betrachtung der Intercalation des Arbeitsions Lithium angewendet. Es hat sich gezeigt, das das Überschußlithium vermutlich auf kristallographische Plätze mit der Wykoff-Bezeichnung 8b eingelagert wird. Zusätzlich wurden temperaturabhängige und sauerstoffpartialdruckabhängige Messungen an den Probenmaterialen durchgeführt, um Aussagen zum Stabilitätsbereich der Phase machen zu können.
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Belmonte, Alessandro. "Essays on political economy". Thesis, IMT Alti Studi Lucca, 2014. http://e-theses.imtlucca.it/158/1/Belmonte_phdthesis.pdf.

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While a vast literature has been collected pointing out the role of the human capital on economic growth, a few has been said, in Economics, on the mechanism through which education directly impacts on democracy. The present dissertation proposes a novel microfoundation of this nexus based on the paramount role of education as economic growth engine and determinant of political participation. The first two works introduce elements of political psychology in order to shed lights on individual cognitive process that might favor, overall, a culture of democracy. Education is then a cognitive tool that citizens/voters can use to decode the information content of political signals and to keep rulers in charge accountable. We formally show that the entire initial distribution of education matters for a successful democracy and that the median is pivotal in the political process. Motivated by that in the last work we propose a statistical analysis of the distribution of the Italian primary school service. Primary schools tend to distribute in a complex way according to geographical features of the territory, schooling aged population density, and possible interactions between the two. Despite the school system is financed at a State level, we outline the persistence of remarkable differences not directly attributable to historical divergences among different macro-area of the country but rather between montane areas and more dynamic regions deputed to explain economic and political divergences. Chapter 2: We propose a political agency model where rent-maximizer rulers are constrained by sophisticated principals/producers that use an awareness-management model `a la B´enabou and Tirole. Sophistication is explained by educational attainments and producers are endowed with different levels of education, that increase over time with human capital investments. We allow education to be both the engine of growth and a determinant of political participation; in equilibrium, more educated societies are more able to punish politicians that, in turn, invest more in productive public goods such as infrastructure, roads or legal rules for contracts enforcement. We prove the existence of multiple steady states featuring, respectively, a sophisticated society with congruent politicians in office, and a naive society ruled by dissonant politicians. Finally, we address inequality concerns and show how, for intermediate values, inequality opposingly hits citizens and ruler and only the latter is found to better off; conversely, citizens are averse to inequality, contributing to explain, via sophisticated accountability, why most people dislike living in a society which is too unequal. Chapter 3: The paper originally attempts to explain the rise of the new wave of populism in Europe and the persistence of the Latin American populism. Such phenomena rose an unresolved political puzzle according to which populist politicians has been widely supported by the electorate while ultimately hurt the economic interests of the majorities. We address this puzzle by looking at the electorate side and, specifically, at individual citizens that are endowed with different level of political sophistication. According to the Political Psychology literature, we approximate political sophistication in terms of individual education attainments whose distribution evolve over time with human capital investments. In each period, the distribution of political sophistication within a country generates different incentive structure for the incumbent that accordingly optimally decide whether to be a populist or a responsible type whereas between countries might determine completely different equilibria in the long run, one with populist politicians and one ruled by responsible ones. I argue that rent-maximizer politicians have the chance to behave in a populist fashion when a naive electorate fail in keeping rulers politically accountable. Despite citizens are politically committed to responsible economic policy, naive voters are basically unaware of the politicians intentions providing to the latter opportunities for the manipulation of the economy and the electoral outcome. Populist rulers carry out inefficient investment with the only intent to induce a mean-increasing spread in future distributions of human capital so as to increase electoral consensus based on a naive electorate and to maximize tax revenues based on a few of rich. Chapter 4: We characterize the statistical law according to which Italian primary school-size distributes. We find that the schoolsize can be approximated by a log-normal distribution, with a fat lower tail that collects a large number of very small schools. The upper tail of the school-size distribution decreases exponentially and the growth rates are distributed with a Laplace PDF. These distributions are similar to those observed for firms and are consistent with a Bose-Einstein preferential attachment process. The body of the distribution features a bimodal shape suggesting some source of heterogeneity in the school organization that we uncover by an indepth analysis of the relation between schools-size and citysize. We propose a novel cluster methodology and a new spatial interaction approach among schools which outline the variety of policies implemented in Italy. Different regional policies are also discussed shedding lights on the relation between policy and geographical features.
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Ben, Halima Nadhir. "Service-Aware Performance Optimization of Wireless Access Networks". Doctoral thesis, University of Trento, 2009. http://eprints-phd.biblio.unitn.it/158/1/PhD-thesis-NBH.pdf.

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Internet was originally designed to offer best-effort data transport over a wired network with end machines using a layered network protocol stack to provide mainly reliability and quality of service for end user applications. However, the excess of wireless end devices and the demand for sophisticated mobile multimedia applications forces the networking research community to think about new design methodologies. In fact, this kind of applications is characterized not only by a large amount of required data-rate, but also by a significant variability of the data-rate over time due to the dynamics of scenes, when state of the art of video encoding techniques are considered and are especially challenging due to the time varying transmission characteristics of the wireless channel and the dynamic quality of service (QoS) requirements of the application (e.g., prioritized delivery of important units, variable bit rate and variable tolerance vs. bit or packet errors). One of the focused issues in the improvement of multimedia transmission quality is to combine the characteristics of the video applications and the wireless networks. Traditional approaches, in which the characteristics of the video application and wireless networks are isolated, would induce the resources not being optimized. Cross-layer design also known as Cross-layering is a new paradigm in network design that not only takes the dependencies and interactions among the layers of the Open System Interface (OSI) structure into account, but also attains a global optimization of the layer-specific parameters. However, most existing cross-layer designs for Quality of Service (QoS) provisioning in multimedia communications are mainly either aiming at improving throughput of the network or reducing power consumption, yet regardless of the end-toend qualities of multimedia transmission. Therefore, the application-driven cross-layer design over various multimedia communication systems is needed to be extensively investigated. Following the extensive study of performance bounds and limitations of the sate of the art in this research area, we argue that performance improvement of multimedia applications over wireless access networks can be achieved through considering the application-specific requirements also called service- or context-awareness. Indeed, we designed two cross-layer design schemes called CORREC and SARC for Wi-Fi and 3G networks respectively. We show that further performance improvement can be achieved by tuning ARQ and HARQ strength respectively based on the application requirements and protocol stack operation on the mobile terminal. In the other hand, the Transmission Control Protocol (TCP) which accounts for over 95% of Internet traffic shows poor performance in wireless domain. We propose a novel approach aiming at TCP performance improvement in WLAN networks. It consists in proposing a joint optimization of ARQ schemes operating at the transport and link layers using a cross-layer approach called ARQ proxy for Wi-Fi networks.
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LOBOSCO, RICARDO LENGRUBER. "THE INCEST N LEVITICU S LAWS. ANALYSIS OF THE HOLINESS LAW (LV 18 & LV 20) IN RELATION TO HAMMURABI S CODE (PARAGRAPHS 154-158) AND THE QUESTION OF SILENCE ABOUT INCEST WITH THE DAUGHTER(S) AT OLD TESTAMENT". PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2007. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=10797@1.

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PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO
As leis existentes em Lv 18 e Lv 20 tratam de relações sexuais consideradas ilícitas, com destaque especial para relações de natureza incestuosa. Tema que está presente, de forma semelhante, nos parágrafos 154 a 158 do Código de Hammurabi. À diferença do segundo, os primeiros textos não proíbem explicitamente a relação incestuosa entre pai e filha(s). A presente Tese propõe analisar cada um dos dois corpora legislativos em seus contextos sócioliterários e compará-los na tentativa de explicar o silêncio existente no Levítico a respeito do incesto. Além disso, a Tese discute o alcance normativo das leis bíblicas à semelhança da discussão teórica existente sobre o tema no que tange ao Direito cuneiforme.
The existing laws in Lv 18 and Lv 20 are about illicit sexual intercourse, with special focus on relationships of incestuous nature. The issue is also present in paragraphs 154 to 158 of the Hammurabi Code. Apart from the second, the first texts do not explicitly forbid incestuous intercourse between father and daughter(s). The present thesis proposes both the analysis of each legislative corpus in their social and literary contexts and their comparison as a way to explain the existing silence on incest in the Leviticus. Besides, this paper discusses the normative reach of biblical laws considering the theoretical discussion about the issue taking the cuneiform Law into consideration.
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Khandai, Santripti. "Band Structure of $Si$ and Geometric Optimization of $SiO_2$ Cluster". Thesis, 2009. http://ethesis.nitrkl.ac.in/158/1/msc_report.pdf.

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In this project we have carried out a computer simulation for the studyof electronic structure of the bulk silicon and geometric structure of $SiO_2$ cluster. We found the charge density and energy band gap for the bulk silicon. The geometric optimization of the cluster $SiO_2 $was undertaken in this project.Finally we supply our results and state the future works in this field.
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Saberi, Mohammad-Ali. "The structure of carbon dioxide adsorbed on a sodium chloride (001) surface". Thesis, 1996. http://spectrum.library.concordia.ca/158/1/MM18435.pdf.

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Two sets of parameters and potential energy surfaces for a single CO$\sb2$ molecule adsorbed on the (001) face of a uniform semi-infinite crystal of NaCl were developed and tested using the Steepest Descent method. When the CO$\sb2$ molecule attains the absolute minimum of the potential energy it was found, for both parameter sets, to lie parallel to the surface at height z = 2.5 A above the connection line of two adjacent Na$\sp+$ ions (along the $\langle 110\rangle$ direction) at 1.994 A from Na$\sp+$ (C to Na$\sp+$); i.e. the carbon atom is directly above the midpoint between two sodium ions. The values of the potential energy were found to be E$\sb\min = {-}7.643$ kcal/mol and E$\sb\min = {-}8.000$ kcal/mol for parameters set I and set II respectively. Saddle points in the potential energy surfaces were found to exist above the connection line between Na$\sp+$ and Cl$\sp-$ (the $\langle 100\rangle$ direction). The position of this point correspond to a lateral sodium to carbon distance of 0.92 A and a carbon height of z = 2.95A above the surface for parameter set I. At this position the molecule is tilted by an angle of $35\sp\circ$ from surface $(55\sp\circ$ from the surface normal). The potential energy at this point was found to be E$\sb{\rm sad} = {-}5.723$ kcal/mol which yielded an estimated diffusion barrier energy of E$\sb{\rm diff} = 1.918$ kcal/mol. The parameter set II was examined the similar results was obtained. The single molecule surface potential which was developed was then used within the Metropolis Monte Carlo method to examine monolayer, bilayer and trilayer configurations of CO$\sb2$ on an NaCl(001) surface. (Abstract shortened by UMI.)
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Diab, Gabriel. "Croissance et recrutement larvaire de l'éperlan arc-en-ciel dans le fjord du Saguenay". Thèse, 2009. http://constellation.uqac.ca/158/1/030112999.pdf.

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Le fjord du Saguenay constitue le plus important tributaire de l'estuaire du St-Laurent. Il abrite une faune ichtyologique diversifiée constituée d'espèces dulcicoies, diadromes et marines. Au cours des 20 dernières années, la pêche sportive hivernale sur le Saguenay a connu une popularité croissante devenant un attrait touristique important pour la région du Saguenay. L'espèce la plus exploitée par cette industrie, en terme de nombre de captures, est l'éperîan arc-en-ciel (Osmerus mordax). Cette espèce constitue une proie de prédilection pour bon nombre d'espèces de poisson, notamment des poissons de fond, également exploités lors de la pêche sportive hivernale. Avant les présents travaux, aucune étude n'avait été faite sur le recrutement larvaire de l'éperîan arc-en-ciel dans le fjord du Saguenay. Face à ce constat, on a cherché à mieux définir les facteurs biotiques et abiotiques ayant une influence sur le recrutement larvaire de Péperlan arc-en-ciel, qui constitue une population propre au fjord du Saguenay. Deux campagnes d'échantillonnage terrain ont eu lieu à l'été 2004 et 2005. Six et cinq missions ont été effectuées respectivement en 2004 et 2005. Lors de ces missions, sept transects ont été échantillonnés sur trois stations pour un total de 21 stations. L'ichtyoplancton a été échantillonné avec un filet bongo et un chalut Tucker de 500 um. Le zooplancton a été récolté, à l'aide d'un filet de 158 um, ainsi que les paramètres physico-chimiques, à l'aide d'une sonde CTD, ont également été prélevés. L'ensemble des larves de poisson ont été dénombrées et identifiées et les otolithes sagittas ont été prélevés sur un total de 576 larves d'éperlan arc-en-ciel. Des calculs de densité, de croissance récente et de trajectoire de croissance ont été faits pour les larves des deux années. Les résultats de cette étude ont démontré que le recrutement larvaire de l'éperlan arc-en-ciel serait principalement limité par deux facteurs. Premièrement, les fluctuations du débit d'eau douce de la rivière Saguenay auraient une influence sur la répartition des larves dans le fjord, les années de fort débit étant défavorables. Deuxièmement, la croissance larvaire de l'éperîan arc-en-ciel serait favorisée par de fortes concentrations du calanoïde Eurytemora affinis. Ces deux facteurs seraient intimement liés puisque les forts débits contribueraient à éloigner les larves d'éperlan des zones à forte concentration de E. affinis dont la Baie des Ha! Ha!. Par ailleurs, les conditions très variables dans le fjord du Saguenay auraient favorisé l'extension de la période d'éclosion qui s'échelonne sur près de deux mois.
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Livros sobre o assunto "158/.1"

1

Williams, Mark. Volume 12: Part 1 (pp. 1-76) | Part 2 (pp. 77-158). London: British Micropalaeontological Society, 1985.

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Mloszewski, Mark J. The geology of the Berekum 1/4° field sheets 154/57 and 158. Accra, Ghana: Minerals Commission/GTZ Publication Project, 1991.

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United States. Congress. Senate. Committee on Energy and Natural Resources., ed. Current National Parks Bills, S. Hrg. 110-158, July 12, 2007, 110-1 Hearing, *. [S.l: s.n., 2008.

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Ankrah, P. T. The geology of the 1/4° field sheets nos. 154/57, 158, and 159, Berekum. Accra, Ghana: Minerals Commission Publication Project, 1992.

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Horton, A. Geology of the Peterborough district: Memoir for 1:50 000 Geological Sheet 158 (England and Wales). London: H.M.S.O., 1989.

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J, Stacey G., e United States. National Aeronautics and Space Administration., eds. The optical depth of the 158 micrometer um [¹²CII] line: Detection of the F=1 --> 0 [¹³CII] hyperfine-structure component. München, Germany: Max-Planck-Institut für extraterrestrische Physik, 1991.

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Šuler, Iva. Registar pravnih propisa u republici hrvatskoj: Propisi objavljeni u Narodnim novinama sa stanjem 1. siječnja 2010 : (Nar. nov., br. 158/09). Zagreb: Novi informator, 2010.

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Katayama, Tohru. Subspace Methods for System Identification. London: Springer London, 2005. http://dx.doi.org/10.1007/1-84628-158-x.

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Liebowitz, Harold. The effect of low velocity impact in the strength characteristics of composite materials laminates: End of the year progress report, NASA grant NAG 1-158. Washington, D.C: School of Engineering and Applied Science, George Washington University, 1986.

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10

Cicero, Marcus Tullius. Cicero on the emotions: Tusculan disputations 3 and 4. Chicago: University of Chicago Press, 2002.

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Capítulos de livros sobre o assunto "158/.1"

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Demaison, J. "158 C2H3ArN Isocyanomethane - argon (1/1)". In Asymmetric Top Molecules. Part 1, 332. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-10371-1_160.

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Hirota, E., K. Kuchitsu, T. Steimle, J. Vogt e N. Vogt. "158 C2H6S Ethene – hydrogen sulfide (1/1)". In Molecules Containing No Carbon Atoms and Molecules Containing One or Two Carbon Atoms, 394. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-540-70614-4_359.

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Hüttner, W. "158 CdNe X0+ (1Σ+) Cadmium − neon (1/1)". In Diamagnetic Diatomic Molecules. Part 1, 215–16. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-540-69954-5_160.

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Kundi, Rishi, Andrew J. Meltzer e Danielle Bajakian. "General Considerations in the Diabetic Patient with Peripheral Vascular Disease". In Diabetes and Peripheral Vascular Disease, 1–12. Totowa, NJ: Humana Press, 2012. http://dx.doi.org/10.1007/978-1-62703-158-5_1.

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Vartanian, Shant M., e Michael S. Conte. "Surgical Treatment of Infrainguinal Occlusive Disease in Diabetes". In Diabetes and Peripheral Vascular Disease, 133–47. Totowa, NJ: Humana Press, 2012. http://dx.doi.org/10.1007/978-1-62703-158-5_10.

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Scali, Salvatore T., e Timothy C. Flynn. "Managing Complications of Vascular Surgery and Endovascular Therapy". In Diabetes and Peripheral Vascular Disease, 149–65. Totowa, NJ: Humana Press, 2012. http://dx.doi.org/10.1007/978-1-62703-158-5_11.

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Nowygrod, Roman, e Nii-Kabu Kabutey. "Diabetes and Lower Extremity Amputation". In Diabetes and Peripheral Vascular Disease, 167–80. Totowa, NJ: Humana Press, 2012. http://dx.doi.org/10.1007/978-1-62703-158-5_12.

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Chung, Christine, Sharif Ellozy, Michael L. Marin e Peter L. Faries. "Diabetic Considerations in Cerebrovascular Disease". In Diabetes and Peripheral Vascular Disease, 181–95. Totowa, NJ: Humana Press, 2012. http://dx.doi.org/10.1007/978-1-62703-158-5_13.

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Kim, In-Kyong, e Rajeev Dayal. "Diabetic Considerations in Aortoiliac Disease". In Diabetes and Peripheral Vascular Disease, 197–209. Totowa, NJ: Humana Press, 2012. http://dx.doi.org/10.1007/978-1-62703-158-5_14.

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Johnston, William F., e Gilbert R. Upchurch. "Abdominal Aortic Aneurysms in Patients with Diabetes". In Diabetes and Peripheral Vascular Disease, 211–25. Totowa, NJ: Humana Press, 2012. http://dx.doi.org/10.1007/978-1-62703-158-5_15.

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Trabalhos de conferências sobre o assunto "158/.1"

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Колодін, Д. О. "ОСОБЛИВОСТІ ОБ’ЄКТИВНОЇ СТОРОНИ КРИМІНАЛЬНОГО ПРАВОПОРУШЕННЯ, ПЕРЕДБАЧЕНОГО СТ. 158-1 КК УКРАЇНИ". In ВОСЬМІ ТАВРІЙСЬКІ ЮРИДИЧНІ НАУКОВІ ЧИТАННЯ. Liha-Pres, 2023. http://dx.doi.org/10.36059/978-966-397-318-0-53.

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Talaska, G., R. Vermeulen, H. Kromout e C. Seon. "158. Distribution of Urinary 1-Hydroxypyrene in Non-Smoking Rubber Workers in the Netherlands". In AIHce 2001. AIHA, 2001. http://dx.doi.org/10.3320/1.2765673.

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Restrepo, J. I., J. P. Conte, J. E. Luco, F. Seible e L. Van Den Einde. "The NEES@UCSD Large High Performance Outdoor Shake Table". In Geo-Frontiers Congress 2005. Reston, VA: American Society of Civil Engineers, 2005. http://dx.doi.org/10.1061/40779(158)1.

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Martín Siguero, A., C. Donoso Rengifo, E. Laguna Ceba, A. Hernández Guío, MG Daniel, G. Vega Achabal e S. Ramos Cillan. "4CPS-158 Relapsed/refractory multiple myeloma and new therapeutic options: experience in a phase 1 clinical trials unit". In 28th EAHP Congress, Bordeaux, France, 20-21-22 March 2024. British Medical Journal Publishing Group, 2024. http://dx.doi.org/10.1136/ejhpharm-2024-eahp.262.

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Rosenthal, James, Alexandra Pike e Matthew S. Reynolds. "A 1 Mbps 158 pJ/bit Bluetooth Low Energy (BLE) Compatible Backscatter Communication Uplink for Wireless Neural Recording in an Animal Cage Environment". In 2019 IEEE International Conference on RFID (RFID). IEEE, 2019. http://dx.doi.org/10.1109/rfid.2019.8719266.

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Collar, Giovanna Carello, Marco Antônio De Bastiani e Eduardo R. Zimmer. "HUNTINGTON’S DISEASE AND EARLYONSET ALZHEIMER’S DISEASE SHARE A TRANSCRIPTOMIC SIGNATURE". In XIII Meeting of Researchers on Alzheimer's Disease and Related Disorders. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1980-5764.rpda082.

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Background: Neurodegenerative diseases share progressive loss of neurons and protein misfolding, which ultimately culminates in dementia; many diseases have been identified as causes of early-onset dementia (< 65 years of age) such as Huntington’s disease (HD) and early-onset Alzheimer’s disease (EOAD). Importantly, disease-specific genetic mutations have already been identified for HD and EOAD. Thus, one could suggest that the molecular link between these diseases may arise from alterations at the transcriptomic level, which is yet to be determined. Objective: We aimed at identifying transcriptome similarities between HD and EOAD. Methods: We collected data of the postmortem cerebral cortex from 1 HD and 6 AD microarray studies in the Gene Expression Omnibus. Of note, only subjects with age at death under 65 were selected (HD: n = 158, controls: n = 158; EOAD: n = 65, controls: n = 266). Differential expression and functional enrichment analyses were performed. Results: We identified 1,260 differentially expressed genes and 675 enriched gene ontology terms between HD and EOAD. Conclusion: Our results demonstrate a transcriptomic signature shared by HD and EOAD. Unveiling the similarities between these diseases at the transcriptomic level could advance our knowledge about pathogenesis and may help to develop therapeutic strategies targeting early-onset dementias.
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Chu, Jinkui, Weiqing Cao e Tingli Yang. "Type Synthesis of Baranov Truss With Multiple Joints and Multiple-Joint Links". In ASME 1998 Design Engineering Technical Conferences. American Society of Mechanical Engineers, 1998. http://dx.doi.org/10.1115/detc98/mech-5972.

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Abstract The method called Single-Open-Chain (SOC) proposed in the literature is a very effective one for structural synthesis of mechanisms; in particular the method suits the synthesis process with the computer. In this paper, a new representation for mechanisms, called Double-Color-Graph (DCG) is introduced. Application of the SOC concept with the help of DCG representation, a new procedure for type synthesis for multiple joints and multiple-joint links, is presented. Baranov Trusses are extensively studied, which results in the finding of 158 independent types of Baranov Trusses with the number of loops being (1–4). A computer program system has been developed to generate all these types.
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Tu, X., e P. Hrnjak. "Pressure Drop Characteristics of R134a Two-Phase Flow in a Horizontal Rectangular Microchannel". In ASME 2002 International Mechanical Engineering Congress and Exposition. ASMEDC, 2002. http://dx.doi.org/10.1115/imece2002-39195.

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Adiabatic two-phase flow pressure drop of R134a have been investigated experimentally in a rectangular channel with hydraulic diameter of 0.14 mm. Single-phase flow experiments were also conducted with liquid and vapor R134a, and an empirical correlation was developed for the turbulent flow regime. The parameter ranges examined for two-phase flow are: mass flux from 158 to 785 kg m−2 s−1; vapor quality from 0.01 to 0.95; and saturation temperature at about 24 ~ 32°C. The experimental data were compared with twelve existing correlations. The homogeneous model and the Mishima and Hibiki (1996) correlation give better predictions than any other correlations.
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Black, Graham, L. E. Jusinski, M. R. Taherian, T. G. Slanger e D. L. Huestis. "N 2 ( A 3 Σ u + ) generation in photodissociated cyanogen-oxygen mixtures". In OSA Annual Meeting. Washington, D.C.: Optica Publishing Group, 1986. http://dx.doi.org/10.1364/oam.1986.wh5.

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F2 (158-nm) and ArF (193-nm) excimer radiation has been used to photodissociate C2N2 and produce chemiluminescence in C2N2–O2 mixtures. In addition LIF measurements have followed the temporal behavior of the CN and NCO radicals. The behavior of CN is understood in terms of its reactions with O2 and O. The NCO decay is controlled by radical or atom intermediates. This study has focused on the NO γ-band chemiluminescence and evidence is presented to support the view that it arises from energy transfer from N2(A) to NO and the N2(A) is made by the reaction N(2D) + NCO → N2(A) + CO. An estimate of ≈25% is obtained for the N2(A) yield of this reaction, assuming a rate coefficient of 1 × 10−10 cm3 mor−1 s−1 (a lower rate would require a proportionately higher yield and vice versa).
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Васин, Дмитрий, e Dmitriy Vasin. "Regular methods for coding of raster images of remote sensing of Earth". In 29th International Conference on Computer Graphics, Image Processing and Computer Vision, Visualization Systems and the Virtual Environment GraphiCon'2019. Bryansk State Technical University, 2019. http://dx.doi.org/10.30987/graphicon-2019-1-152-158.

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The work is devoted to the consideration of the issues of eliminating information redundancy of raster data of remote sensing of the Earth (RDRSE), including the latest hyperspectral data (HSD). The characteristic properties of raster hyperspectral images (RHSI) are listed, a brief description of the existing methods of RDRSE compression is given. The possibility of using local, homogeneous "well-adapted" basic functions (LHWABF) to eliminate information redundancy and adaptive compression of RDRSE is considered. An algorithm for constructing a LHWABF system for the RHSI based on the Chebyshev approximation is proposed. The results of computational experiments are given. The effectiveness of the proposed method of adaptive compression RHSI is shown.
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Relatórios de organizações sobre o assunto "158/.1"

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SGC, Servicio Geológico Colombiano. Elaboración de la cartografía geológica de un conjunto de planchas a escala 1:100.000, ubicadas en cuatro bloques del territorio nacional, identificados por el Servicio Geológico Colombiano - Plancha 158 Caño Juriepe. Contrato N° 511 de 2013. Producto. Versión 2015. Bogotá: Servicio Geológico Colombiano, junho de 2015. http://dx.doi.org/10.32685/10.143.2015.173.

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Dorman, Eleanor, Zara Markovic-Obiago, Julie Phillips, Richard Szydlo e Darren K. Patten. Wellbeing in UK Frontline Healthcare Workers During Peaks One and Three of the COVID-19 Pandemic: A Retrospective Cross-Sectional Analysis. Science Repository, dezembro de 2022. http://dx.doi.org/10.31487/j.ejgm.2022.01.01.

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Background: COVID-19 had a huge impact on the wellbeing of healthcare workers (HCWs). This is well documented during the first peak of the pandemic. With cases in the UK rising for a third peak, hospitalisations and deaths surpassing the first, there is very little known about the mental health of HCWs during this time. Methods: Using a questionnaire, data was collected from patient-facing staff at Barking, Havering, and Redbridge University Trust to quantify and compare the period prevalence of symptoms of depression, anxiety, and PTSD during the first peak (P1: March-May 2020) and third peak (P3: December 2020-Feburary 2021) of the COVID-19 pandemic as well as wellbeing service use, demographics of responders and what they found most difficult during the peaks. Results: Of 158 responders, only 22·4% felt they had enough access to wellbeing services during P1 and 21·5% in P3. Of those who used wellbeing services 34·4% found them useful in P1 and 34·6% in P3. 70·3% of responders felt that not enough was done for staff wellbeing. The median anxiety score decreased from P1 (10(range 5-17)) to P3 (8(range 4-16)) p=0·031. Under 30-year-olds’ depression and PTSD scores increased from P1 to P3 (depression: P1 7(1-11), P3 8(3-14), p=0·048, PTSD: P1 4(0-7) peak 3 5(2-9), p=0·037). Several groups showed a decrease in anxiety scores from P1 to P3 including; over 30-year-olds (P1 10(5-17), P3 7(3-15) p=0·002), BME responders (P1 8(3·75-15) P3 6·5(1-12) p=0·006), AHP (P1 14(7-19), P3 11(5-19) p=0·005), ITU workers (P1 15(8-18·25) P3 12(5·75-18·25) p=0·004), and those who were redeployed (P1 8(5-18·25), P3 5(2-14·75), p=0·032). Conclusion: We have observed changes in mental health symptoms within the study population as the peaks of the pandemic continue. With the majority of responders reporting they felt not enough had been done for their wellbeing support - and of those who used the wellbeing services only around 1/3 felt they were useful - we hope that this paper can help inform wellbeing provision and identify groups at higher risk of developing mental health symptoms.
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3

Barefoot, Susan F., Bonita A. Glatz, Nathan Gollop e Thomas A. Hughes. Bacteriocin Markers for Propionibacteria Gene Transfer Systems. United States Department of Agriculture, junho de 2000. http://dx.doi.org/10.32747/2000.7573993.bard.

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The antibotulinal baceriocins, propionicin PLG-1 and jenseniin G., were the first to be identified, purified and characterized for the dairy propionibaceria and are produced by Propionibacterium thoenii P127 and P. thoenii/jensenii P126, respectively. Objectives of this project were to (a) produce polyclonal antibodies for detection, comparison and monitoring of propionicin PLG-1; (b) identify, clone and characterize the propionicin PLG-1 (plg-1) and jenseniin G (jnG) genes; and (3) develop gene transfer systems for dairy propionibacteria using them as models. Polyclonal antibodies for detection, comparison and monitoring of propionicin PLG-1 were produced in rabbits. Anti-PLG-1 antiserum had high titers (256,000 to 512,000), neutralized PLG-1 activity, and detected purified PLG-1 at 0.10 mg/ml (indirect ELISA) and 0.033 mg/ml (competitive indirect ELISA). Thirty-nine of 158 strains (most P. thoenii or P. jensenii) yielded cross-reacting material; four strains of P. thoenii, including two previously unidentified bacteriocin producers, showed biological activity. Eight propionicin-negative P127 mutants produced neither ELISA response nor biological activity. Western blot analyses of supernates detected a PLG-1 band at 9.1 kDa and two additional protein bands with apparent molecular weights of 16.2 and 27.5 kDa. PLG-1 polyclonal antibodies were used for detection of jenseniin G. PLG-1 antibodies neutralized jenseniin G activity and detected a jenseniin G-sized, 3.5 kDa peptide. Preliminary immunoprecipitation of crude preparations with PLG-1 antibodies yielded three proteins including an active 3-4 kDa band. Propionicin PLG-1 antibodies were used to screen a P. jensenii/thoenii P126 genomic expression library. Complete sequencing of a cloned insert identified by PLG-1 antibodies revealed a putative response regulator, transport protein, transmembrane protein and an open reading frame (ORF) potentially encoding jenseniin G. PCR cloning of the putative plg-1 gene yielded a 1,100 bp fragment with a 355 bp ORF encoding 118 amino acids; the deduced N-terminus was similar to the known PLG-1 N-terminus. The 118 amino acid sequence deduced from the putative plg-1 gene was larger than PLG-1 possibly due to post-translational processing. The product of the putative plg-1 gene had a calculated molecular weight of 12.8 kDa, a pI of 11.7, 14 negatively charged residues (Asp+Glu) and 24 positively charged residues (Arg+Lys). The putative plg-1 gene was expressed as an inducible fusion protein with a six-histidine residue tag. Metal affinity chromatography of the fused protein yielded a homogeneous product. The fused purified protein sequence matched the deduced putative plg-1 gene sequence. The data preliminarily suggest that both the plg-1 and jnG genes have been identified and cloned. Demonstrating that antibodies can be produced for propionicin PLG-1 and that those antibodies can be used to detect, monitor and compare activity throughout growth and purification was an important step towards monitoring PLG-1 concentrations in food systems. The unexpected but fortunate cross-reactivity of PLG-1 antibodies with jenseniin G led to selective recovery of jenseniin G by immunoprecipitation. Further refinement of this separation technique could lead to powerful affinity methods for rapid, specific separation of the two bacteriocins and thus facilitate their availability for industrial or pharmaceutical uses. Preliminary identification of genes encoding the two dairy propionibacteria bacteriocins must be confirmed; further analysis will provide means for understanding how they work, for increasing their production and for manipulating the peptides to increase their target species. Further development of these systems would contribute to basic knowledge about dairy propionibacteria and has potential for improving other industrially significant characteristics.
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