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Ummia Sa'adah, Ferci, Deddy Kurniawan e Selpa Dewi. "PERENCANAAN STRUKTUR PEMBANGUNAN GEDUNG 3 LANTAI SMPN 9 BUKITTINGGI". Ensiklopedia Research and Community Service Review 2, n.º 1 (4 de novembro de 2022): 97–104. http://dx.doi.org/10.33559/err.v2i1.1364.
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Perencanaan Struktur gedung SMPN 9 Bukittinggi bertujuan untuk meningkatkan daya tampung siswa/I dibukittinggi. Perencanaan ini merencanakan pembangunan struktur gedung untuk mencapai perencanaan yang kuat, aman, serta memenuhi syarat yang telah di atur dalam peraturan-peraturan yang berlaku untuk perencanaan struktur gedung. Perencanaan Struktur SMPN 9 Bukittinggi dipreliminary Desaign menggunakan ETABS. Pembeban yang diinput pada ETABS ialah beban mati, beban hidup, berat sendiri bangunan, beban gempa. Dari hasil preliminary desaign didapatkan haril penulangan balok induk (BI 1) ukuran 35 40 dengan mutu beton 30 Mpa, mutu baja 400 Mpa, penulangan tumpuan atas 4D16, tumpuan bawah 2D16, penulangan lapangan atas 4D16, lapangan bawah 2D16, tulangan sengkang tumpuan 10 100, sengkang lapangan 10 - 150. Kolom ukuran 60 45 mutu beton 30 Mpa, Mutu Baja 400 Mpa tulangan total aksial 24 D 22. Penulangan pelat atap tumpuan 10 150, lapangan 10 - 300. Penulangan pelat lantai tumpuan 10 – 150, lapangan 10 – 300. Dari perencanaan diatas dapat disimpulkan telah memenuhi syarat dan ketentuan yang ada pada peraturan dan standar indonesia.Kata Kunci : Struktur Balok, Kolom, Pelat lantai, Pelat Atap, Pembebanan, Tulangan
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Wang, Huanbin, Kuntan Wu, Xiaomei Mi, Shahid Ali Rajput e Desheng Qi. "Effects of 3-Hydroxy-3-methylglutaryl-CoA Reductase Inhibitors on Cholesterol Metabolism in Laying Hens". Animals 13, n.º 11 (3 de junho de 2023): 1868. http://dx.doi.org/10.3390/ani13111868.
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This study aimed to investigate the effect of HMGCR inhibitors on egg yolk cholesterol content and its biological mechanisms. Four groups of 180-day-old laying hens (n = 8 cages/group, 6 laying hens/cage) were fed a corn/soybean-based diet (control) and the control diet supplemented with an HMGCR inhibitor at 60, 150, and 300 mg/kg for 4 weeks. The experimental results showed that adding HMGCR inhibitors of 150 mg/kg or more can significantly reduce the cholesterol content in the liver, yolk, serum, and pectoral muscles of laying hens. The RNA-seq results showed that compared with the control group, the addition of HMGCR inhibitors of 150 mg/kg or more to the diet significantly upregulated genes related to cholesterol synthesis in the liver, and the genes involved in steroid synthesis and metabolism, sterol synthesis and metabolism, and cholesterol synthesis and metabolism were all affected by the HMGCR inhibitors. In summary, adding HMGCR inhibitors of 150 mg/kg or more to the diet of hens can significantly reduce the cholesterol content in egg yolk. After the HMGCR inhibitors inhibited the activity of the liver HMGCR, they also altered the expression of genes related to cholesterol synthesis, bile acid synthesis, and cholesterol transport in the liver, and ultimately reduced cholesterol synthesis and cholesterol transport to the egg yolk.
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Dougados, M., U. Kiltz, A. Kivitz, K. Pavelka, S. Rohrer, S. Mccreddin, E. Quebe-Fehling, B. Porter e Z. Talloczy. "THU0374 NONSTEROIDAL ANTI-INFLAMMATORY DRUG-SPARING EFFECT OF SECUKINUMAB IN PATIENTS WITH ANKYLOSING SPONDYLITIS: 4-YEAR RESULTS FROM THE MEASURE 2, 3 AND 4 PHASE 3 TRIALS". Annals of the Rheumatic Diseases 79, Suppl 1 (junho de 2020): 419–20. http://dx.doi.org/10.1136/annrheumdis-2020-eular.824.
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Background:Nonsteroidal anti-inflammatory drugs (NSAIDs) are effective in reducing pain and stiffness in ankylosing spondylitis (AS) patients (pts).1However, continuous use of NSAIDs may lead to gastrointestinal, cardiovascular and renal toxicity.2Therefore, reduction in NSAID intake is desirable in AS pts.Objectives:To evaluate the long-term effect of secukinumab (SEC) on NSAID intake in AS pts pooled from the 3 SEC trials (MEASURE [M] 2-4).Methods:NSAID intake was evaluated prospectively using the Assessment of SpondyloArthritis International Society (ASAS)-NSAID score.3The score was determined by type of NSAID, daily dose, and weights from frequency of intake, as well as % of time use in period. An ASAS-NSAID score of ‘0’ indicates no NSAID intake. Pts with ASAS-NSAID score >0 at baseline (BL) were analysed. SEC dose groups were defined as Any 150 or 300 mg, as defined for pooled safety analyses for SEC. Pts with initial placebo treatment (up to 24 weeks) were included in their respective post-Week 24 SEC dose groups to analyse ASAS-NSAID score at Year (Y) 2 (M2-4), Y3 (M2-3) and Y4 (M2) from BL. From the ASAS-NSAID score at BL, the mean change in ASAS-NSAID score, proportion of pts achieving 50% reduction, and the proportion of pts with score <10 were evaluated for each dose at Y2, 3 and 4. Based on the distribution of ASAS-NSAID scores at BL, 2 subgroups were evaluated: (i) <75 (low user); (ii) ≥75 (high user).Results:Overall, 562 pts (SEC: 150 mg, N=467; 300 mg, N=95) were analysed. The mean ASAS-NSAID score decreased with time in both dose groups. Greater improvements were observed in high NSAID users and with longer treatment exposure (Figure). Proportion of pts who achieved 50% reduction in ASAS-NSAID score increased with time in both SEC 150 and 300 mg groups. Proportion of pts with clinically meaningful reduction of ASAS-NSAID score <10 increased with time in both dose groups and in both low and high NSAID users (Table).TableTime (years)NSAID intakeLow (<0 ASAS-NSAID <75)High (ASAS-NSAID ≥75)OverallSEC 150 mg(N=167)SEC 300 mg#(N=37)SEC 150 mg(N=300)SEC 300 mg#(N=58)SEC 150 mg(N=467)SEC 300 mg#(N=95)Proportion of pts who achieved 50% reduction from BL in ASAS-NSAID score, % (n/m)*225 (38/154)18 (6/33)19 (50/267)14 (7/49)21 (88/421)16 (13/82)323 (13/56)21 (7/33)26 (26/100)17 (8/46)25 (39/156)19 (15/79)429 (7/24)-26 (14/54)-27 (21/78)-Proportion of pts with ASAS-NSAID score <10,% (n/m)*239 (60/154)33 (11/33)12 (33/267)12 (6/49)22 (93/421)21 (17/82)334 (19/56)33 (11/33)17 (17/100)13 (6/46)23 (36/156)22 (17/79)438 (9/24)-20 (11/54)-26 (20/78)-*Observed data.#MEASURE 3 that evaluated 300 mg was only a 3 year study. N, total number of pts in the group; n, number of pts with response; m, number of evaluable ptsConclusion:SEC provided sustained improvement in ASAS-NSAID score in AS pts and was associated with clinically relevant NSAID-sparing effect in AS pts, when used to measure NSAID intake up to 4 years of treatment. Overall, SEC provided long-term NSAID-sparing effects in both high and low NSAID users.References:[1]Molto A, et al.Joint Bone Spine. 2017;84:79–82.[2]Dougados M, et al.Arthritis Res & Ther. 2014;16:481.[3]Dougados M, et al.Ann Rheum Dis. 2011;70:249–51.Disclosure of Interests:Maxime Dougados Grant/research support from: AbbVie, Eli Lilly, Merck, Novartis, Pfizer and UCB Pharma, Consultant of: AbbVie, Eli Lilly, Merck, Novartis, Pfizer and UCB Pharma, Speakers bureau: AbbVie, Eli Lilly, Merck, Novartis, Pfizer and UCB Pharma, Uta Kiltz Grant/research support from: AbbVie, Amgen, Biogen, Novartis, Pfizer, Consultant of: AbbVie, Biocad, Eli Lilly and Company, Grünenthal, Janssen, Novartis, Pfizer, UCB, Speakers bureau: AbbVie, MSD, Novartis, Pfizer, Roche, UCB, Alan Kivitz Shareholder of: AbbVie, Amgen, Gilead, GSK, Pfizer Inc, Sanofi, Consultant of: AbbVie, Boehringer Ingelheim,,Flexion, Genzyme, Gilead, Janssen, Novartis, Pfizer Inc, Regeneron, Sanofi, SUN Pharma Advanced Research, UCB, Paid instructor for: Celgene, Genzyme, Horizon, Merck, Novartis, Pfizer, Regeneron, Sanofi, Speakers bureau: AbbVie, Celgene, Flexion, Genzyme, Horizon, Merck, Novartis, Pfizer Inc, Regeneron, Sanofi, Karel Pavelka Speakers bureau: AbbVie, BMS, MSD, UCB, Medac, Egis, Pfizer, Roche, Biogen, Novartis, Susanne Rohrer Employee of: Novartis, Suzanne McCreddin Shareholder of: Novartis, Employee of: Novartis, Erhard Quebe-Fehling Shareholder of: Novartis, Employee of: Novartis, Brian Porter Shareholder of: Novartis, Employee of: Novartis, Zsolts Talloczy Shareholder of: Novartis, Employee of: Novartis
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Lepangkari, Jaka Seprianto, Novi Elisa e Irvan Charles Seran. "Uji Aktivitas Antihipertensi Ekstrak Etanol Daun Matoa (Pometia pinnata J.R. Forster & G. Forster) pada Tikus Jantan yang Diinduksi Angiotensin II dengan Parameter Blood Flow". Publikasi Penelitian Terapan dan Kebijakan 6, n.º 1 (27 de junho de 2023): 65–72. http://dx.doi.org/10.46774/pptk.v6i1.532.
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Hipertensi adalah naiknya tekanan darah sistolik dan diastolik lebih dari 140/90. Salah satu tanaman yang berpotensi sebagai antihipertensi adalah matoa yang mengandung senyawa Quercetin-3-O-rhamnoside dan Kaemferol 3-O-rhamnoside yang diyakini berpotensi sebagai antihipertensi. Pada penelitian ini, peneliti ingin mengetahui persentase penurunan blood flow pada tikus jantan yang diinduksi angiotensin II menggunakan ekstrak etanol daun matoa. Pengerjaan ini dimulai dengan membuat ekstrak etanol dari daun matoa dan membaginya dalam 3 variasi dosis, yaitu 75 mg/kgBB, 150 mg/kgBB, dan 300 mg/kgBB, kemudian diberikan perlakuan ke hewan uji yang telah diinduksi angiotensin II. Hasil penelitian menunjukkan bahwa variasi 3 dosis ekstrak etanol daun matoa dengan dosis 75 mg/kgBB, 150 mg/kgBB, dan 300 mg/kgBB, menunjukkan hasil berbeda. Ekstrak etanol daun matoa dengan dosis 75 mg/kgBB memiliki persentase penurunan 44.47%. Ekstrak etanol daun matoa dengan dosis 150 mg/kgBB memiliki persentase penurunan 53.36%. Ekstrak etanol daun matoa dengan dosis 300 mg/kgBB memiliki persentase penurunan 67.35%. Disimpulkan bahwa ekstrak terbaik yang berpotensi dalam menurunkan sirkulasi aliran darah atau blood flow adalah ekstrak etanol daun matoa dosis 300 mg/kgBB.
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van der Heijde, Désirée, Philip J. Mease, Robert B. M. Landewé, Proton Rahman, Hasan Tahir, Atul Singhal, Elke Boettcher et al. "Secukinumab provides sustained low rates of radiographic progression in psoriatic arthritis: 52-week results from a phase 3 study, FUTURE 5". Rheumatology 59, n.º 6 (5 de outubro de 2019): 1325–34. http://dx.doi.org/10.1093/rheumatology/kez420.
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Abstract Objective To evaluate the effect of secukinumab on radiographic progression through 52 weeks in patients with PsA from the FUTURE 5 study. Methods Patients with active PsA, stratified by prior anti-TNF use (naïve or inadequate response), were randomized to s.c. secukinumab 300 mg load (300 mg), 150 mg load (150 mg), 150 mg no load regimens or placebo at baseline, at weeks 1, 2 and 3 and every 4 weeks starting at week 4. Radiographic progression was assessed by change in van der Heijde-modified total Sharp score (vdH-mTSS; mean of two readers). Statistical analysis used a linear mixed-effects model (random slope) at weeks 24 and 52, and observed data at week 52. Assessments at week 52 included additional efficacy endpoints (non-responders imputation and mixed-effects models for repeated measures) and safety. Results The majority (86.6%) of patients completed 52 weeks of treatment. The proportion of patients with no radiographic progression (change from baseline in vdH-mTSS ⩽0.5) was 91.8, 85.2 and 87.2% in 300, 150 and 150 mg no load groups, respectively, at week 52. The change in vdH-mTSS from baseline to week 52 using random slope [mean change (s.e.)] was –0.18 (0.17), 0.11 (0.18) and –0.20 (0.18) in 300, 150 and 150 mg no load groups, respectively; the corresponding observed data [mean change (s.d.)] was –0.09 (1.02), 0.13 (1.39) and 0.21 (1.15). Clinical efficacy endpoints were sustained, and no new or unexpected safety signals were reported through 52 weeks. Conclusion Secukinumab 300 and 150 mg with or without s.c. loading regimen provided sustained low rates of radiographic progression through 52 weeks of treatment. Trial registration ClinicalTrials.gov, http://clinicaltrials.gov, NCT02404350.
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Strober, Bruce, Peter Van de Kerkhof, Heng Fan, Eugenia Levi e Andrew Blauvelt. "Efficacy of Secukinumab in Patients With Mild to Moderate Psoriasis: A Pooled Analysis of 6 Phase 3 Studies". SKIN The Journal of Cutaneous Medicine 7, n.º 6 (13 de novembro de 2023): s231. http://dx.doi.org/10.25251/skin.7.supp.231.
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Introduction: Secukinumab has demonstrated sustained long-term efficacy for the treatment of patients with moderate to severe plaque psoriasis, but efficacy in mild to moderate psoriasis has not been rigorously evaluated. The secukinumab phase 3 clinical trial program included patients with mild to moderate psoriasis among populations with active psoriatic arthritis (EXCEED and FUTURE 2-5; NCT02745080, NCT01752634, NCT01989468, NCT02294227, and NCT02404350), and among patients with moderate to severe palmoplantar psoriasis (GESTURE; NCT01806597). Here, we report efficacy and safety of secukinumab in a pooled population of patients with mild to moderate psoriasis.
Methods: This post hoc analysis included patients from the phase 3 EXCEED, FUTURE 2-5, and GESTURE trials, with mild to moderate psoriasis defined as either a baseline affected body surface area (BSA) of 3%-10% or a baseline Investigator’s Global Assessment modified 2011 score (IGA) of 2 or 3. Patients were pooled by treatment received through Week 16 (treatment period 1) and from Weeks 16 to 52 (treatment period 2), according to the following groups: treatment period 1 (secukinumab 300 mg, secukinumab 150 mg, or placebo) and treatment period 2 (secukinumab 300 mg or secukinumab 150 mg). Efficacy was assessed by the proportion of patients achieving 75% improvement in the Psoriasis Area and Severity Index (PASI75), PASI90, and PASI100 among patients with a BSA 3%-10%; and by IGA 0/1 response with ≥2-point improvement among patients with baseline IGA score of 2 or 3. Descriptive statistics were reported for each outcome. Missing data were imputed using non-responder imputation.
Results: Overall, 654 patients and 971 patients had mild to moderate psoriasis at baseline as defined by a BSA of 3%-10% or IGA score of 2 or 3, respectively. Demographics and baseline disease characteristics were similar between populations defined by BSA and by IGA. Among patients with a baseline BSA of 3%-10%, secukinumab resulted in greater achievement of PASI75/90/100 vs placebo at Week 12 (secukinumab 300 mg: 62.8%/44.4%/33.1%; secukinumab 150 mg: 48.0%/29.1%/19.4%; placebo: 11.7%/9.0%/8.0%), with increased responses at Week 52 (secukinumab 300 mg: 65.7%/56.5%/47.3%; secukinumab 150 mg: 58.1%/40.5%/31.3%). The proportion of patients with baseline IGA=2 or 3 achieving IGA 0/1 response with ≥2-point improvement was greater among patients receiving secukinumab 300 mg (46.6%) or 150 mg (37.2%) than placebo (8.6%) at Week 12, with increased responses at Week 52 (secukinumab 300 mg: 52.5%; secukinumab 150 mg: 44.4%).
Conclusions: Secukinumab led to improvements in measures of disease severity among patients with mild to moderate psoriasis after 12 weeks of treatment vs placebo in a pooled analysis of patients with psoriatic arthritis or palmoplantar psoriasis. Both doses of secukinumab showed increased efficacy from Week 12 to Week 52.
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Pavelka, Karel, Alan J. Kivitz, Eva Dokoupilova, Ricardo Blanco, Marco Maradiaga, Hasan Tahir, Yi Wang et al. "Secukinumab 150/300 mg Provides Sustained Improvements in the Signs and Symptoms of Active Ankylosing Spondylitis: 3‐Year Results from the Phase 3 MEASURE 3 Study". ACR Open Rheumatology 2, n.º 2 (fevereiro de 2020): 119–27. http://dx.doi.org/10.1002/acr2.11102.
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Xia, Z., D. Yu, J. Mao, Z. Zhang e J. Yu. "The occurrence of Dirofilaria immitis, Borrelia burgdorferi, Ehrlichia canis and Anaplasma phagocytophium in dogs in China". Journal of Helminthology 86, n.º 2 (11 de maio de 2011): 185–89. http://dx.doi.org/10.1017/s0022149x11000198.
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AbstractA survey of the occurrence of Dirofilaria immitis, Borrelia burgdorferi, Ehrlichia canis and Anaplasma phagocytophium in dogs was undertaken in the People's Republic of China between October 2008 and October 2009. A total of 600 blood samples were taken from dogs in four cities in China: 300 in Beijing, 150 in Shenzhen, 30 in Shanghai and 120 in Zhengzhou. All samples were tested for the heartworm antigen and antibodies of canine B. burgdorferi, E. canis and A. phagocytophium by using the canine SNAP® 4Dx® test kit. The occurrence of D. immitis, B. burgdorferi, E. canis and A. phagocytophium was 1.17% (7/600), 0.17% (1/600), 2.17% (13/600) and 0.5% (3/600), respectively. In Shenzhen city 2% (3/150), 8.67% (13/150) and 2% (3/150) of samples were positive for D. immitis, E. canis and A. phagocytophium, respectively. The occurrence of heartworm antigen was 0.33% (1/300) in Beijing, 2.00% (3/150) in Shenzhen, 3.33% (1/30) in Shanghai and 1.67% (2/120) in Zhengzhou. We found E. canis and A. phagocytophium only at one site, Shenzhen, while the only occurrence of B. burgdorferi was at Beijing. In conclusion, the dog population in China is at potential risk for D. immitis, B. burgdorferi, E. canis and A. phagocytophium infection, the risk being especially high in southern China.
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Giacomini, Alessandra Aparecida, Waldssimiler Teixeira de Mattos, Herbert Barbosa de Mattos, Joaquim Carlos Werner, Eduardo Antonio da Cunha e Dora Duarte de Carvalho. "Crescimento de raízes dos capins aruana e tanzânia submetidos a duas doses de nitrogênio". Revista Brasileira de Zootecnia 34, n.º 4 (agosto de 2005): 1109–20. http://dx.doi.org/10.1590/s1516-35982005000400004.
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Foram avaliadas características do sistema radicular (pré e pós-pastejo) dos capins aruana e tanzânia submetidos a doses de nitrogênio (150 e 300 kg ha-1 de N) e pastejados por ovinos em lotação rotacionada com três a sete dias de pastejo e período de descanso variável. O delineamento experimental foi o de blocos completos casualizados (dois) com duas repetições, em esquema de parcelas subdivididas (parcelas =capins e subparcelas=doses de N) e medidas repetidas no tempo. No pré-pastejo, o capim-tanzânia, na média entre doses de N e períodos de pastejo, apresentou maior quantidade de massa seca da matéria orgânica (MSMO) (1,7 mg cm-3 de solo) que o capim-aruana (1,2 mg cm-3 de solo), além de maior comprimento de raízes (119,1 cm cm-3 de solo e 68,7 cm cm-3 de solo, respectivamente). A dose de 300 kg ha-1 de N contribuiu para maior comprimento do sistema radicular (107,1 cm cm-3 de solo) que a dose de 150 kg ha-1 de N (80,7 cm cm-3 de solo). O crescimento radicular pós-pastejo demonstrou similaridade de comportamento entre as variáveis mensuradas, de modo que o crescimento de raízes se tornou mais evidente após a segunda semana de rebrotação. Na média de capins, doses de N e idades de crescimento, no período equivalente ao outono/inverno, o crescimento de raízes (em MSMO foi de 3,9 mg 100 cm-3) aumentou para 12,9 mg 100 cm-3 no inverno, caiu para 4,7 mg 100 cm-3 na primavera e elevou novamente para 17 mg 100 cm-3 no verão. Comportamento semelhante foi observado para comprimento e superfície de raízes, coincidindo os períodos de maior crescimento com os de maior pluviosidade. A dose de 150 kg ha-1 de N promoveu maior crescimento em comprimento e superfície de raízes que a dose de 300 kg ha-1 de N nos períodos de maior pluviosidade.
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Baiyeri, Kayode Paul, Ihechiluru Akachukwu, Onyinye Joy Okonkwo e Uchenna Immaculata Ezugwu. "Studies on the production of tigernut (Cyperus esculentus L.) in Southeastern Nigeria, I: Effect of seven complementary fertilizer treatments on growth and yield of tigernut in pot". Bio-Research 22, n.º 1 (27 de março de 2024): 2302–8. http://dx.doi.org/10.4314/br.v22i1.8.
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Tigernuts have so many food and medicinal potentials as it contains some amount of vitamins, minerals and phytochemicals. Despite the food and health benefits associated with this tuber, its production in southern Nigeria is at an abysmal level probably due to lack of knowledge for its production or utility. This experiment was conducted at the University of Nigeria Teaching and Research Farm to evaluate the effect of seven complementary fertilizer treatments on the growth and yield of tigernut. The experiment is an attempt to develop appropriate agronomic practice that will assure regular cultivation culture. The experimental design was a completely randomized design with seven fertilizer treatments and replicated 10 times. Treatments were NPK 15:15:15 (300 kg/ha), NPK 20:10:10 (300 kg/ha), poultry manure, PM, (5 t/ha), NPK 15:15:15 (150 kg/ha) + 3 t/ha PM, NPK 20:10:10 (150 kg/ha) + 3 t/ha PM, K-nitrate (100 kg/ha) + Ca-nitrate (100 kg/ha) + 2.5 t/ha PM and control (No fertilizer application). Fertilizer treatments significantly (p < 0.05) influenced growth and yield parameters except fresh weight of leaves, length of longest root and weight of seed planted. Significantly (p < 0.05) superior values of growth and yield parameters were obtained in plants grown with NPK 15:15:15 (300 kg/ha), followed closely by the application of NPK 20:10:10 at 150 kg/ha plus 3 t/ha PM. This study recommends application of NPK 15:15:15 (300 kg/ha) or the combined application of organic and inorganic fertilizer (NPK 20:10:10 at 150 kg/ha plus 3 t/ha PM) to boost the yield and growth of tigernut.
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Maulana Assidiq, Bagas, Dian Arumningsih DP e Gatot Nursetyo. "PERENCANAAN STRUKTUR GEDUNG RUMAH SAKIT RAWAT INAP 5 (LIMA) LANTAI COLOMADU DAN RENCANA ANGGARAN BIAYA". Journal of Civil Engineering and Infrastructure Technology 2, n.º 2 (15 de dezembro de 2023): 17–26. http://dx.doi.org/10.36728/jceit.v2i2.3117.
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Pertambahan jumlah penduduk pada Kecamatan Colomadu yang meningkat serta perkembangan aktivitas manusia mendorong pembangunan fisik kota. Pembangunan sarana kesehatan dalam sebuah kawasan perlu dilakukan dalam upaya mendukung program peningkatan derajat kesehatan masyarakat. Maka dirancanglah satu gedung rumah sakit 5 lantai di Kecamatan Colomadu. Perencanaan struktur ini bertujuan merencanakan struktur gedung yang aman, nyaman, dan efisien serta mengetahui rencana anggaran biaya yang dibutuhkan. Hasil yang didapat adalah pelat atap tebal 10 cm tulangan x dan y Ø12 – 200 mm, pelat lantai tebal 12 cm tulangan x dan y Ø12 – 150 mm, balok induk B1 dimensi 300 x 500 mm tulangan atas 2 D19 tulangan bawah 3 D19 tulangan geser Ø10 – 150 mm, balok induk B2 dimensi 300 x 450 mm tulangan atas 2 D19 tulangan bawah 3 D19 tulangan geser Ø10 – 150 mm, balok anak BA dimensi 200 x 300 mm tulangan atas 3 D10 tulangan bawah 3 D10 tulangan geser Ø10 – 150 mm, balok sloof TB dimensi 250 x 400 mm tulangan atas 3 D16 tulangan bawah 6 D16 tulangan geser Ø10 – 150 mm, kolom K1 dimensi 600 x 600 mm tulangan longitudinal 16 D19 dan tulangan geser Ø10 – 150 mm, adalah kolom K2 dimensi 500 x 500 mm tulangan longitudinal 16 D19 dan tulangan geser Ø10 – 200 mm, penulangan pondasi bore pile dimensi 60 cm kedalaman 8 m dengan tulangan longitudinal 10 D22 tulangan spiral Ø16 – 200 mm, dan rencana anggaran biaya dengan total anggaran Rp. 13.280.305.901,00.
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Anderson, Malcolm, Carolyn Moore e Mary C. A. Griffin. "Effect of heat treatment on casein micelle profiles obtained by controlled pore-glass chromatography". Journal of Dairy Research 53, n.º 4 (novembro de 1986): 585–93. http://dx.doi.org/10.1017/s0022029900033100.
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SummaryThe effect of heat treatment on the profiles of casein micelles obtained at 340 and 280 nm from controlled pore-glass chromatography of milk was studied in a series of unhomogenized whole milk samples which had been heated in a pilot plant at 75, 90, 105, 120, 135 and 150 °C for holding times of 4, 16, 32, 72, 150 and 300 s. A second experiment was carried out in which whole milk was preheated at temperatures between 70 and 110 °C for 13, 60 and 180 s before being treated at 120 °C for 4 s or 150 °C for 16 s. The average micelle size in some of the samples was determined by photon correlation spectroscopy. Profiles were divided into four fractions in which micelle size decreased from fraction 1 to fraction 4. The dimensions of these fractions were expressed in terms of size relative to that of the total profile. Fraction 4 was not affected by any of the heat treatments. Fractions 1–3 were significantly affected only by temperatures above 120 °C. Between 120 and 150 °C fraction 1 increased significantly while fractions 2 and 3 showed a corresponding decrease. Holding time affected fraction 1 only above 120 °C. For fraction 2 there was no effect in < 32 s at temperatures less than 150 °C. Fraction 3 was the most sensitive to changes in holding time, but no effect was observed below 105 °C. Average micelle size measurements indicated that a substantial size increase only occurred in those milks heated at 135 °C for longer than 16 s and in all the samples at 150 °C. To assess whether this increase in micelle size was reversible, samples were dialysed against a 70 mm-NaCl solution containing 10 mm-EDTA and then separated by column chromatography on Sephacryl S-300. The proportion of materials which was undissociated by dialysis remained unchanged for temperatures below 120 °C, but progressively increased with treatments more severe than 120 °C for 16 s. Column profiles were not influenced by variations in the conditions of preheating
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Anderson, Daniel D., Leon G. Higley, Alex R. Martin e Fred W. Roeth. "Competition Between Triazine-Resistant and -Susceptible Common Waterhemp (Amaranthus rudis)". Weed Science 44, n.º 4 (dezembro de 1996): 853–59. http://dx.doi.org/10.1017/s0043174500094820.
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The relative competitiveness of triazine-resistant (TR) and -susceptible (TS) common waterhemp, as a component of fitness, was assessed using TR and TS biotypes collected from the same field in Fillmore County, Nebraska. Competition between biotypes was evaluated under greenhouse conditions using a set of replacement series experiments with five ratios of TR:TS (1:0, 3:1, 1:1, 1:3, and 0:4) and four plant densities (50, 100, 150, and 300 plants m−2). No difference in final individual plant weight between TR and TS plants was observed in the absence of interbiotypic competition at all plant densities examined. Interbiotypic competition was indicated by ANOVA of plant weight and modified relative crowding coefficients (RCC) for plant weight, height, and volume. Replacement series diagrams showed TS plants were more competitive than TR plants, as measured by plant weight at densities of 50, 100, and 150 plants m−2. TS and TR plants were equally competitive at 300 plants m−2. Individual TS plant weight for 50, 100, and 150 plants m−2was greatest at the 3:1 ratio (TR:TS) and decreased as the proportion of susceptible plants increased. Individual TR plant weight for 50, 100, and 150 plants m−2was greatest at the 1:0 ratio and decreased as the TR proportion decreased. Lack of interbiotypic competition at 300 plants m−2and decreasing TS plant weight with increasing ratios suggest intrabiotypic competition. RCC values for volume and height were calculated weekly during the experiment and indicated the competitive advantage of TS plants was constant from transplanting through harvest.
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Kiliroong, Maria, Hadi Wael, Alwi Smith e Syahran Wael. "Viscosity and organoleptic test of gude bean soy sauce (Cajanus cajan L.)". BIOEDUPAT: Pattimura Journal of Biology and Learning 1, n.º 2 (18 de outubro de 2021): 71–78. http://dx.doi.org/10.30598/bioedupat.v1.i2.pp71-78.
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Gude nuts are known as wooden nuts on Kisar Island, which is an area that uses wood nuts as food. This study aims to determine the viscosity value and organoleptic test of pigeon pea sauce based on the weight of the beans. This research was conducted in February - March 2021 at the Laboratory of the Biology Education Study Program, FKIP, Pattimura University, Ambon and a viscosity test at the Ambon Industrial Standardization and Research Institute (Baristand) using an experimental research type and the research design used was a completely randomized design ( RAL), using 3 treatments, namely the weight of pigeon pea 150 g, 300 g and 450 g and using 2 replications to obtain 6 samples. This study showed that the weight of pigeon pea had an effect on the viscosity and organoleptic of soy sauce. From the viscosity analysis, the highest viscosity was obtained, namely 608.065 cp with a weight of 450 g pigeon pea, while for pigeon pea 300 g 411.065 cp and 150 g gude beans at 141 cp and organoleptic test obtained the average value of the texture of soy sauce on the treatment of pigeon pea and soy sauce 450 g pigeon pea 300 g with an average value of 4 (very thick) and peanut gude 150 g with an average value of 3 (thick). In the flavor of pigeon pea sauce 300 g and 150 g have an average value of 3 (fragrant), while for the treatment of 450 g peanuts is 4 (very fragrant). The color of the soy sauce in the pigeon pea sauce treatment was 450 g and 300 g with an average value of 4 (very black), and the 150 g peanut sauce treatment was 3 (black). In the treatment of 450 g of pigeon pea sauce and 300 g of pigeon pea sauce, the average value was 3 (sweet). For 150 g of pigeon pea soy sauce, on average the panelists gave a score of 2 (less sweet). There is an influence on the viscosity because the weight of the nuts used is different. while the organoleptic test showed a thick, fragrant, less sweet, and sweet taste.
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Simanjuntak, Bistok Hasiholan, e Ratna Dewi P. "PENGGUNAAN INDOLE-3-BUTYRIC ACID (IBA) UNTUK MENINGKATKAN PERTUMBUHAN STEK BATANG KOPI ROBUSTA". Agrin 24, n.º 2 (29 de março de 2021): 111. http://dx.doi.org/10.20884/1.agrin.2020.24.2.505.
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Perbanyakan kopi robusta (Coffea canephora) dengan metode stek sering terkendala pada pertumbuhan akar dan tunas daun. Pemberian Indole-3-Butyric Acid (IBA) diharapkan dapat mengatasi masalah pertumbuhan akar dan tunas pada stek batang. Tujuan penelitian ini adalah untuk menemukan konsentrasi IBA yang tepat terhadap pertumbuhan akar dan tunas daun stek kopi robusta. Penelitian ini menggunakan Rancangan Acak Kelompok (RAK) nonfaktorial dengan perlakuan konsentrasi IBA terdiri atas 0 ppm, 50 ppm, 100 ppm, 150 ppm, 200 ppm, 250 ppm, dan 300 ppm, dan diulang 4 kali. Parameter pengamatan meliputi panjang akar, jumlah daun, bobot basah dan kering berangkasan stek batang. Hasil penelitian menunjukkan bahwa pemberian IBA 150 ppm pada stek batang kopi robusta mampu menghasilkan panjang akar terbaik. Namun demikian, seluruh konsentrasi IBA yang diujikan belum mampu meningkatkan jumlah daun, berat berangkasan basah, dan berat berangkasan kering stek batang kopi robusta.Kata kunci: Indole Butyric Acid, kopi robusta, stek batang,
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Ismail, Nur Izzati, Siti Rozaimah Sheikh Abdullah, Mushrifah Idris, Hassimi Abu Hasan, Nadya Hussin Al Sbani e Omar Hamed Jehawi. "Preliminary Test of Mining Wastewater Containing Iron (III) and Aluminium (III) on Scirpus grossus in Phytoremediation Process". Applied Mechanics and Materials 773-774 (julho de 2015): 1111–15. http://dx.doi.org/10.4028/www.scientific.net/amm.773-774.1111.
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Preliminary test was conducted to physically observe and determine the range of Fe and Al concentrations that Scirpus grossus can grow and survive. Pails of 3 L containing 3 kg of sand and 42 days old S. grossus were exposed to different concentrations of Fe and Al solution mixture for 21 days. The mass ratio between Fe and Al in the solution mixture was 3:1. After 21 days of exposure, the plants had shown that they could grow and survive in concentrations up to 300 mg/L Fe + 100 mg/L Al. Effect concentration (EC50)value for single Fe and Al toxicity to S. grossus was predicted between 300 mg/L Fe + 100 mg/L Al and 450 mg/L Fe + 150 mg/L Al. Therefore, it is suggested for the next study of phytotoxicity the Fe and Al concentrations range may start as low as 30 mg/L Fe + 10 mg/L Al up to 450 mg/L Fe + 150 mg/L Al.
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Yamaoka, Hitoshi, Tetsuro Mochizuki, Yoshiharu Sakurai e Hiroshi Kawata. "Bent-crystal monochromators for high-energy synchrotron radiation". Journal of Synchrotron Radiation 5, n.º 3 (1 de maio de 1998): 699–701. http://dx.doi.org/10.1107/s0909049597018645.
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Two kinds of monochromators covering the energy ranges 100–150 keV and ∼300 keV have been designed for inelastic (Compton) scattering experiments at the elliptical multipole wiggler beamline, BL08W, of SPring-8. Finite-element analyses using ANSYS for bent crystals indicate that thermal problems are not serious for the 300 keV monochromator, while an energy spread of about 10−3 for the 100–150 keV monochromator is possible in the centre of the crystal. Detailed calculations of X-ray interaction with the silicon crystal were performed. The results show that Compton scattering is a dominant process and deposits about 100 W continuously.
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Mease, Philip J., Robert Landewé, Proton Rahman, Hasan Tahir, Atul Singhal, Elke Boettcher, Sandra Navarra et al. "Secukinumab provides sustained improvement in signs and symptoms and low radiographic progression in patients with psoriatic arthritis: 2-year (end-of-study) results from the FUTURE 5 study". RMD Open 7, n.º 2 (julho de 2021): e001600. http://dx.doi.org/10.1136/rmdopen-2021-001600.
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ObjectiveSecukinumab provided sustained efficacy, low radiographic progression and consistent safety over 52 weeks in patients with psoriatic arthritis (PsA) in the FUTURE 5 study. Here, we report 2-year (end-of-study) results from this study.MethodsAdults with active PsA were randomised 2:2:2:3 to receive subcutaneous secukinumab 300 mg load (300 mg), 150 mg load (150 mg), 150 mg no load or placebo at baseline; weeks 1, 2, 3 and 4; and every 4 weeks thereafter. Secukinumab could be escalated from 150 mg to 300 mg starting at week 52, if active signs of disease were observed based on physician’s assessment. Assessments at week 104 (2 years) included clinical end points and radiographic damage (mean change in van der Heijde-modified total Sharp score (vdH-mTSS)). Safety analysis included all patients who received ≥1 dose of study medication.ResultsOf the 996 patients randomised, 783 patients (78.6%) completed 2 years of treatment. Improvement in clinical end points was sustained through 2 years. The vdH-mTSS (mean change (SD)) was 0.10 (1.74; 300 mg), 0.52 (2.66; 150 mg) and 0.41 (2.20; 150 mg no load) at 2 years. The proportion of patients with no radiographic progression (change from baseline in vdH-mTSS ≤0.5) at 2 years was 89.5% (300 mg), 82.3% (150 mg) and 81.1% (150 mg no load).ConclusionSecukinumab with and without loading regimen provided sustained clinical efficacy and low radiographic progression through 2 years in patients with PsA. No new safety findings were reported.Trial registration numberNCT02404350.
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MacMillan, Margaret L., Bruce R. Blazar, Todd E. Defor, Kathryn E. Dusenbery, Michael R. Verneris, Heather Zierhut e John E. Wagner. "Alternative Donor Hematopoietic Cell Transplantation In 94 Patients with Fanconi Anemia at the University of Minnesota". Blood 116, n.º 21 (19 de novembro de 2010): 3526. http://dx.doi.org/10.1182/blood.v116.21.3526.3526.
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Abstract Abstract 3526 Alternative donor hematopoietic cell transplantation (AD-HCT) for patients with Fanconi anemia (FA) is challenging. We report on the outcomes of 94 patients with FA, median age 9.0 (range 1–33) years, who underwent AD-HCT at our institution from 1999–2010, using one of three consecutive prospective phase II total body irradiation (TBI) containing clinical trials. With each trial, one change was made from the previous trial to systematically study the optimal AD-HCT approach for FA patients. In Trial 1, from 1999–2003, fludarabine (FLU) 140 mg/m2 was added to the conventional cyclophosphamide (CY), antithymocyte globulin (ATG), TBI 450 cGy preparative regimen to overcome the high risk of graft failure. In Trial 2, from 2003–2006, CT guided thymic shielding (TS) was included during TBI to improve immune reconstitution. In Trial 3, from 2006–2010, a TBI dose-de-escalation trial with TS was performed to determine the lowest possible dose of TBI required for engraftment. All patients received CY 40 mg/kg, FLU 140 mg/m2, ATG and single fraction TBI using 150, 300 or 450 cGy, with or without TS as per specific protocol. Graft-versus-host disease (GVHD) prophylaxis consisted of cyclosporin A and methylprednisolone. Graft sources included T-cell depleted bone marrow (BM; n=75), single umbilical cord blood (UCB, n=17) or double UCB (n=2). At the time of HCT, 74 patients had aplastic anemia (AA) and 16 patients demonstrated early MDS defined as refractory anemia (RA, n=8), refractory anemia with ringed sideroblasts (RARS), RA with multilineage dysplasia (RCMD, n=4) or RCMD and ringed sideroblasts (RCMD-RS, n=4). One patient had RA with excess blasts-2 (RAEB-2) and 3 patients had acute myeloid leukemia (AML). For the entire cohort of 94 patients, probabilities of neutrophil and platelet engraftment were 97% and 75%, respectively. In Trial 3, two recipients of TBI 150 cGy developed secondary graft failure and dose de-escalation was stopped at TBI 300 cGy. For all patients, probabilities of grade II-IV and grade III-IV acute GVHD were 23% and 10%. Probability of chronic GVHD was 13%. In multivariate analysis of 89 patients (excluding 3 patients with GFR <40 and 2 recipients of TBI 150), higher 3-year mortality was associated with older age (>10 years), and any transfusions prior to HCT. Lower 3-year mortality was associated with Trial 3 (Table). Of the 8 patients in Trial 3 who were <10 years of age and never received transfusions before HCT, 7 are alive and well. Immune reconstitution and infectious disease data analyses are in progress. Table: Factors Associated with 3 Year Survival after HCT: Multiple Regression Analysis Factors N Relative Risk (95% CI) P-value Trial 1: Cy-Flu-ATG-TBI 450* 43 1.0 2: Cy-Flu-ATG-TBI 450+TS 16 0.7 (0.3–1.7) 0.39 3: Cy-Flu–ATG-TBI 300+TS 30 0.4 (0.1–1.0) 0.04 Age 210* 49 1.0 >10 40 2.1 (1.0–4.4) 0.05 Prior Transfusions None* 27 1.0 1–20 45 2.7 (1.0–7.5) 0.05 >20 17 2.9 (1.0–8.8) 0.06 * reference Based on the results of the largest single center analysis of alternative donor HCT for FA patients, four findings emerge: (1) TBI 300 cGy +TS with CY-FLU-ATG is sufficient for consistent engraftment but TBI 150 cGy +TS is not adequate; (2) rates of GVHD are low with T cell depletion; (3) patients with FA and marrow failure should be referred to HCT before receiving transfusions, and (4) superior survival is associated with CY-FLU-ATG-TBI 300+TS followed by T-cell depleted AD-BM or unmanipulated UCB, potentially due to enhanced immune recovery. Longer follow-up is required to determine whether this approach is associated with reduced late effects, particularly endocrinopathies and malignancy. Disclosures: Wagner: CORD:USE: Membership on an entity's Board of Directors or advisory committees; VidaCord: Membership on an entity's Board of Directors or advisory committees.
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Saputra, Farid, Mochammad Afifuddin e Abdullah Abdullah. "PERILAKU BALOK PROFIL KANAL (C) KONSFIGURASI (I) FERROFOAM CONCRETE DENGAN VARIASI TINGGI PROFIL AKIBAT BEBAN LENTUR". Jurnal Teknik Sipil 1, n.º 4 (15 de fevereiro de 2018): 823–30. http://dx.doi.org/10.24815/jts.v1i4.10042.
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Abstract: Many areas have inadequate transportation infrastructure. The current technological developments, demanding the construction of easy to move. To accomplish this, a concrete technology is required that can provide lightweight concrete with high strength. Lightweight concrete technology is also urgently needed, to make innovations in the technical work of the new world of construction. For that combination of ferrocement and foam concrete can be a technology solution needed by the people of Indonesia today. The purpose of this study was to obtain information about the behavior of the confined ferrofoam concrete channel block beam I due to the bending load. The observed behavior in this research is the capacity of the beam in accepting the load, the deflection that occurs as well as the resulting crack pattern and the type of collapse. The test specimen to be made is a C-shaped profile with a height variation of 1500 mm, 200 mm, and 300 mm, a width of 100 mm, and a thickness of 30 mm. Test object repeats using D8 (Threaded Steel), and wiremesh layer of 3 layers. Mix design based on specific gravity of 1600 kg/m3 with FAS 0,4 and addition of pozolan equal to 10%. Results obtained 200-3L test object increased capacity by 38% compared to 150-3L test object, 300-3L increased by 97% compared to 150-3L. 200-3L test object decreased deflection by 12% compared to 150-3L, 300-3L test object decreased 61% compared to 150-3L. 200-3L test specimen increased 7% ductility compared to 150-3L test object, 300-3L increased by 76% compared to 150-3L. The overall profile failure is a sliding bending failure. Abstrak: Banyak daerah yang infrastruktur transportasinya belum memadai. Perkembangan teknologi saat ini, menuntut adanya konstruksi yang mudah untuk dipindahkan. Untuk mewujudkan hal ini, dibutuhkan suatu teknologi beton yang bisa menyediakan beton ringan dengan kekuatan yang tinggi. Teknologi beton yang ringan juga sangat dibutuhkan, untuk membuat inovasi dalam teknis pekerjaan baru didunia konstruksi. Untuk itu kombinasi wiremesh dan foam concrete bisa menjadi solusi teknologi yang dibutuhkan oleh masyarakat Indonesia saat ini. Tujuan dari penelitian ini adalah mendapatkan informasi tentang perilaku dari balok profil kanal ferrofoam concrete yang dikonfigurasi I akibat beban lentur. Perilaku yang ditinjau pada penelitian ini berupa kapasitas balok dalam menerima beban, lendutan yang terjadi serta pola retak yang dihasilkan dan jenis keruntuhannya. Benda uji yang akan dibuat adalah profil berbentuk kanal C dengan variasi tinggi masing-masing 1500 mm, 200 mm, dan 300 mm, lebar 100 mm, dan ketebalan 30 mm. Penulangan benda uji menggunakan D8 (Baja Ulir), dan lapisan wiremesh sebanyak 3 lapisan. Mix design berdasarkan berat jenis yaitu 1600 kg/m3 dengan FAS 0,4 dan penambahan pozolan sebesar 10%. Hasil yang didapatkan benda uji 200-3L terjadi peningkatan kapasitas sebesar 38% dibandingkan benda uji 150-3L, 300-3L meningkat sebesar 97% dibanding 150-3L. Benda uji 200-3L terjadi penurunan lendutan sebesar 12% dibandingkan benda uji 150-3L, 300-3L menurun sebesar 61% dibanding 150-3L. Benda uji 200-3L terjadi peningkatan daktilitas sebesar 7% dibandingkan benda uji 150-3L, 300-3L meningkat sebesar 76% dibanding 150-3L. Kegagalan profil yang terjadi secara keseluruhan yaitu kegagalan lentur geser.
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Archer, David F., Juki Ng, Kristof Chwalisz, Yi-Lin Chiu, Eve C. Feinberg, Charles E. Miller, Robert A. Feldman e Cheri E. Klein. "Elagolix Suppresses Ovulation in a Dose-Dependent Manner: Results From a 3-Month, Randomized Study in Ovulatory Women". Journal of Clinical Endocrinology & Metabolism 105, n.º 3 (25 de outubro de 2019): 821–32. http://dx.doi.org/10.1210/clinem/dgz086.
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Abstract Context Elagolix is an oral gonadotropin-releasing hormone (GnRH) antagonist recently approved for the treatment of endometriosis-associated pain and being developed for heavy menstrual bleeding associated with uterine fibroids. Objective The objective was to evaluate the effects of elagolix on ovulation and ovarian sex hormones. Design and Setting This was a randomized, open-label, multicenter study. Participants Participants were healthy ovulatory women aged 18 to 40 years. Interventions Elagolix was administered orally for 3 continuous 28-day dosing intervals at 100 to 200 mg once daily (QD), 100 to 300 mg twice daily (BID), and 300 mg BID plus estradiol/norethindrone acetate (E2/NETA) 1/0.5 mg QD. Main Outcome Measures The main outcomes measures were ovulation rates measured by transvaginal ultrasound, progesterone concentrations, and hormone suppression. Results Elagolix suppressed ovulation in a dose-dependent manner. The percentage of women who ovulated was highest at 100 mg QD (78%), intermediate at 150 and 200 mg QD and 100 mg BID (47%–57%), and lowest at 200 and 300 mg BID (32% and 27%, respectively). Addition of E2/NETA to elagolix 300 mg BID further suppressed the ovulation rate to 10%. Elagolix also suppressed luteinizing hormone and follicle stimulating hormone in a dose-dependent manner, leading to dose-dependent suppression of estradiol and progesterone. Elagolix had no effect on serum biomarker of ovarian reserve, and reduced endometrial thickness compared to the screening cycle. Conclusion Women being treated with elagolix may ovulate and should use effective methods of contraception. The rate of ovulation was lowest with elagolix 300 mg BID plus E2/NETA 1/0.5 mg QD.
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Blagodatsky, G. A., A. A. Kopysov, V. V. Khvorenkov e I. S. Baturin. "Cognitive Radio System Operational Control Algorithm". Bulletin of Kalashnikov ISTU 22, n.º 4 (30 de dezembro de 2019): 93. http://dx.doi.org/10.22213/2413-1172-2019-4-93-106.
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Представлен алгоритм оптимального управления системой когнитивного радио в аналоговых и цифровых режимах работы. Алгоритм основан на применении критериев принятия решений в условиях изменяющейся обстановки. Основой алгоритма является максимизация коэффициента эффективности системы в рассматриваемых режимах. Таким образом, система когнитивного радио может выбрать оптимальный режим работы как в конкретной внешней ситуации, так и предпочтительный режим работы при учете всех внешних воздействий.Для эффективной передачи информации при значительно разряженной батарее радиосистеме требуется перейти в режим E3 (мощность 1, 3, 10 Вт; скорость 2400, 9600 бит/с; тип СКК (вид модуляции) 4FSK, QPSK, QPSK; частота 30…300 ОВЧ (VHF) МГц; полоса 6,25/12,5; 6,25/12,5; 25/50/100/150 кГц). Для повышения эффективности передачи информации в этом режиме также целесообразно продолжить управление сигнально-кодовыми конструкциями. При продолжении работы во временных ограничениях требуется перейти в режим работы E4 (мощность 1, 3, 10 Вт; скорость 2400, 9600 бит/с; Тип СКК (вид модуляции) 4FSK, QPSK, QPSK; частота 300…3000 УВЧ (UHF) МГц; полоса 6,25/12,5; 6,25/12,5; 25/50/100/150 12,5 кГц) и направить ресурсы радиосистемы на управление мощностью передачи, тем самым повышая эффективность за счет усиления энергетики радиолинии. Для передачи цифровой речи при разряженной батарее требуется перейти в режим E1 (мощность 1, 10, 100 Вт; скорость 2400, 1200, 800 бит/с; Тип СКК (вид модуляции) OFDM (SSB), QPSK; частота 3…30 ВЧ (HF) МГц; полоса 3,1 кГц), и для повышения эффективности уже требуется управление сигнально-кодовыми конструкциями. При наступлении временных ограничений радиосистеме требуется перейти в режим работы E2 (мощность 1, 3, 10 Вт; скорость 2400, 1200, 800 бит/с; тип СКК (вид модуляции) 4FSK, QPSK, QPSK; частота 30…300 ОВЧ (VHF) МГц; полоса 6,25/12,5; 6,25/12,5; 25/50/100/150 кГц), и для повышения достоверности приема-передачи требуется ресурсы потратить на управление мощностью передачи.Рассматривая эффективность работы радиосистемы в аналоговых и цифровых режимах, можно сделать вывод, что при наступлении временных ограничений эффективно управление мощностью передатчика (увеличение энергетики радиолинии). Однако при работе в цифровых режимах снижение эффективности происходит значительно медленнее, чем при использовании аналоговых режимов. Анализ работы радиосистемы при энергетических ограничениях также показывает более медленное снижение эффективности цифровых режимов; кроме того, в цифровых режимах значительно снижается скорость расхода ресурсов, в то время как в аналоговых режимах она резко возрастает.
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Susilawati, Susilawati, Lidwina Ninik S., Mery Hasmeda e Irmawati Irmawati. "The Effect of Plant Growth Regulator on Duku (Lansium domesticum Corr.) Flower for Fruit Formation". Ilmu Pertanian (Agricultural Science) 2, n.º 3 (14 de dezembro de 2018): 100. http://dx.doi.org/10.22146/ipas.28293.
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Plant growth regulators have a significant impact on increasing both quality and quantity of plant yield for either mixed or separated application. The research was aimed to identify the effect of spraying plant growth regulators on duku flowers for fruit formation. The research was conducted from December 2014 to May 2015 in Sijacarana Local Technical Implementation Unit (UPTD) of Propagation, South Sumatra Province in Ogan Komering Ulu (OKU) Timur Regency. Duku tree used was 15 years old with the height around 10 meter. Complete Randomized Design was used with 3 replications where duku trees as the replicates. The spraying consisted of 3 single plant growth regulator treatments and 6 mixed treatments which were P1 (BAP 300 mg.L-1), P2 (NAA 300 mg.L-1), P3 (GA3 300 mg.L-1), P4 (BAP 100 mg. L-1 + GA3 200 mg.L-1), P5 (BAP 200 mg.L-1 + GA3 100 mg.L-1), P6 (BAP 150 mg.L-1 + GA3 150 mg.L-1), P7 (NAA 100 mg.L-1 + GA3 200 mg.L-1), P8 (NAA 200 mg.L-1 + GA3 100 mg.L-1), P9 (NAA 150 mg.L-1 + GA3 150 mg.L-1). Spraying was applied twice with a half dosage for each application. First application was performed about one month after flowering, and the second was one and a half month after flowering. Data were analyzed using analysis of variance and least significance difference at α 5%. The measurement of parameters were carried after harvest or 3 months after treatment. Results showed that plant growth regulator positively affected duku fruit formation. GA3 treatment then was considered as the best treatment as it had a unison in fruit maturity, the highest number of fruit per bunch, weight per fruit and total fruit weight per bunch, and had the lowest number of green fruit and seed per fruit.
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Kumar, Sanjeev, Gangandeep Kaur, Amba Vaidehi, Avinash Kishore, Anaba Asif e Mitul Joshi. "Comparitive evaluation of BMI & academic performance in ECC & non ECC 3-6 yr old school going children". International Journal of Oral Health Dentistry 7, n.º 3 (15 de setembro de 2021): 199–202. http://dx.doi.org/10.18231/j.ijohd.2021.039.
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To study the association between ECC, IQ & health in Sri ganganagar, Rajasthan. to assess BMI & academic performance in ECC & Non ECC 3-6yr old school going children in Sri ganganagar, Rajasthan. A total of 300 children were evaluated and oral examination was done using BMI scale – CDC (Centers for disease control and prevention), Weight scale- Unificare company Height scale – 200 cm Roll Ruller wall Mounted Height Stadiometer, Academic performance grade as per school record & Dentition status for caries assessment was conducted using dmf index of WHO form 1997. . A total of 300 school going children were selected from Sri ganganagar, Rajasthan of which 150 were having ECC & 150 Non ECC in the age groups of 3, 4, 5 and 6 years. Correlation between the ECC & Academic performance is stated.
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Huda, A., S. A. Halim, K. P. Lim, O. J. Lee, S. Elias, A. A. Sidek e Z. Hishamuddin. "Effect of Ru Substitution on Structural, Electrical Transport and Magnetoresistive of La2/3Ba1/3MnO3". Materials Science Forum 517 (junho de 2006): 45–48. http://dx.doi.org/10.4028/www.scientific.net/msf.517.45.
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Polycrystalline samples of La0.67Ba0.33(Mn1-xRux)O3 with x = 0, 0.05, 0.1, 0.15 and 0.2 have been prepared using solid state reaction. The effects of doping of Ru at Mn site on La-Ba-Mn- O ceramics, the characteristics and magnetotransport properties of CMR materials are investigated. The magnetoresistance (MR) effect is measured using the four point probe technique. The magnetoresistance defined as MR% = (Ro – RH)/RH x 100% was measured at a magnetic field of H ≤ 1T at 90K, 100K, 150K, 200K, 250K, 270K and 300K for the sample of doping x = 0, 0.05, 0.1, 0.15 and 0.2. Overall, MR drops slowly when temperature rises. All doping concentration gives small variation range (~2.7% to ~26.78%). The electrical property has determined by using standard four-point probe resistivity measurement in a temperature range of 30 K to 300 K. Metalinsulator transition temperature (Tp) shifted to lower temperatures as Ru doping is increased. In this paper the structural pattern and microstructure property have investigated via XRD. XRD patterns show that these systems are in orthorhombic distorted perovskite structures.
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Berti, Christian Luis Ferreira, Takeshi Kamada, Mariana Pina da Silva, June Faria Scherrer Menezes e Ana Carolina Silva Oliveira. "CRESCIMENTO DE MUDAS DE BARU EM SUBSTRATO ENRIQUECIDO COM NITROGÊNIO, FÓSFORO E POTÁSSIO". Cultura Agronômica: Revista de Ciências Agronômicas 26, n.º 2 (1 de abril de 2017): 191–202. http://dx.doi.org/10.32929/2446-8355.2017v26n2p191-202.
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O baru (Dipteryx alata Vog.) é uma espécie nativa do cerrado que apresenta potencial para diversos usos, inclusive em programas de recuperação de áreas degradadas. Porém, pouco se conhece sobre seus aspectos silviculturais, principalmente suas exigências nutricionais. O objetivo com esta pesquisa foi avaliar o crescimento inicial de mudas de baru em substrato comercial enriquecido com nitrogênio, fósforo e potássio. O delineamento experimental utilizado foi o inteiramente casualizado, com cinco tratamentos e quatro repetições, sendo cada repetição representada por 12 mudas. Os tratamentos foram: controle (somente substrato comercial); adubação nitrogenada (150 g m-3 de N utilizando sulfato de amônio na semeadura + 1,0 kg de sulfato de amônio diluído em 100 L de água aplicado em cobertura); adubação fosfatada (300 g m-3 de P2O5 utilizando superfosfato simples na semeadura); adubação potássica (100 g m-3 de K2O utilizando cloreto de potássio na semeadura + 0,3 kg de cloreto de potássio diluído em 100 L de água aplicado em cobertura) e; completo (mistura contendo N, P2O5 e K2O, sendo 150, 300 e 100 g m-3, respectivamente, na semeadura, + 1,0 kg de sulfato de amônio e 0,3 kg de cloreto de potássio aplicados em cobertura). O substrato comercial utilizado foi composto por casca de pinus e fibra de coco. As avaliações morfológicas das mudas foram realizadas aos 100 dias após a semeadura e, verificou-se que, o crescimento das mudas de baru não foi alterado pela adição de nutrientes no substrato comercial. Com base nos resultados obtidos, conclui-se que as mudas de baru não apresentaram resposta à aplicação de N, P e K, demonstrando potencial para o plantio em solos com baixos teores desses nutrientes.
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Kalinkov, M., e I. Kuneva. "Space Distribution of the Richest Abell Clusters of Galaxies". Symposium - International Astronomical Union 130 (1988): 533. http://dx.doi.org/10.1017/s0074180900136629.
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We discuss four samples from the Abell (1958) catalog of clusters of galaxies. Our samples are drawn out from the Abell sample and all clusters have richness 2 and 3. With Ho = 100 km/s/Mpc and qo = +1, we examine the following volumes, defined for both galactic hemispheres: (i)RG 3: b 40° for 0° < 1 360° and b 30° for 90° < 1 240°, distance 300 < R < 750 Mpc, N = 35 clusters, 30 of which with known redshift;(ii)RG 3: b −35° for 15° < 1 232°, 150 < R < 600 Mpc, N = 15 (13);(iii)RG 2: b and 1 as (i), 60 < R < 525 Mpc, N = 110 (55);(iv)RG 2: b and 1 as (ii), 120 < R < 600 Mpc, N = 102(14).
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Kuncoro, Rohmanu Dwi. "Analisis Resetting Relay Dan Load Presentase Terhadap Pola Pelaksanaan Dan Pemeliharaan Pada Gardu Induk 150 Kv Saketi Banten". ELPOSYS: Jurnal Sistem Kelistrikan 8, n.º 2 (2 de julho de 2021): 16–22. http://dx.doi.org/10.33795/elposys.v8i2.46.
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Abstrac: The Saketi substation has three 150/70 kV power transformers with a capacity of 3x60 MVA with a frequency of 50 Hz where all three transformers have the capacity, transformer 1 60 MVA (PAUWELS TRAFO) has 3 feeders with an average load of 300 A, 10 MW, transformer 2 60 MVA (UNINDO) has 3 feeders with an average load of 200 A, 6.9 MW and transformer 3 60 MVA (UNINDO) has 4 feeders with an average load of 300 A, 10 MW. This calculation and simulation analysis is carried out aiming to find out the relay settings on each transformer under normal conditions and in a maintenance state on one of the transformers for a long period of time. From the results of the analysis and calculation, it was found that the OCR relay setting under normal conditions of the incoming 150 kV transformer transformers 1, 2, and 3 has a current setting value of 0.92 A and a time setting of 0.36 seconds. On the outgoing side the 20 kV transformers 1, 2, and 3 have a setting of 1,039 A and a time setting of 0.166 seconds.
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Kuncoro, Rohmanu Dwi, Ahmad Hermawan e Rhezal Agung Ananto. "Analisis Resetting Relay Dan Load Presentase Terhadap Pola Pelaksanaan Dan Pemeliharaan Pada Gardu Induk 150 Kv Saketi Banten". Elposys: Jurnal Sistem Kelistrikan 8, n.º 2 (30 de junho de 2021): 50–56. http://dx.doi.org/10.33795/elposys.v8i2.632.
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The Saketi substation has three 150/70 kV power transformers with a capacity of 3x60 MVA with a frequency of 50 Hzwhere all three transformers have the capacity, transformer 1 60 MVA (PAUWELS TRAFO) has 3 feeders with an average load of 300 A, 10 MW, transformer 2 60 MVA (UNINDO) has 3 feeders with an average load of 200 A, 6.9 MW and transformer 3 60 MVA (UNINDO) has 4 feeders with an average load of 300 A, 10 MW. This calculation and simulation analysis is carried out aiming to find out the relay settings on each transformer under normal conditions and in a maintenance state on one of the transformers for a long period of time. From the results of the analysis and calculation, it was found that the OCR relay setting under normal conditions of the incoming 150 kV transformer transformers 1, 2, and 3 has a current setting value of 0.92 A and a time setting of 0.36 seconds. On the outgoing side the 20 kV transformers 1, 2, and 3 have a setting of 1,039 A and a time setting of 0.166 seconds.
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NAMIR, MOHAMMAD, MOHAMED A. RABIE, NOURHAN A. RABIE e MOHAMED FAWZY RAMADAN. "Optimizing the Addition of Functional Plant Extracts and Baking Conditions To Develop Acrylamide-Free Pita Bread". Journal of Food Protection 81, n.º 10 (18 de setembro de 2018): 1696–706. http://dx.doi.org/10.4315/0362-028x.jfp-18-150.
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ABSTRACTThe effects of using freeze-dried extracts (FDEs) of spearmint (Mentha spicata), fennel (Foeniculum vulgare), and turmeric (Curcuma longa) as well as adjusting the baking temperature and time on acrylamide formation in pita bread were investigated to obtain the most acceptable conditions that produced the lowest acrylamide concentrations. A Box-Behnken design was adopted for optimization of the pita bread formulations by adding FDEs (3 to 25 g/100 g of wheat flour) and adjusting the baking temperature (200 to 300°C) and baking time (3 to 11 min), and the effects of these changes on color parameters, phytochemical attributes, and acrylamide concentrations were evaluated. Increasing the concentration of FDE and decreasing the baking temperature and time considerably decreased the acrylamide concentration in bread for all experimental trials. No acrylamide was detected in pita bread formulated with 25 g of mint FDE/100 g of wheat flour and baked at 250°C for 3 min, formulated with 25 g of mint or fennel FDE/100 g and baked at 300°C for 7 min, formulated with 3 g of mint, fennel, or turmeric FDE/100 g and baked at 200°C for 7 min, formulated with 14 g of mint FDE/100 g and baked at 300°C for 3 min, and formulated with 25 g of mint or fennel FDE/100 g and baked at 200°C for 7 min. Pita breads formulated with fennel and turmeric FDE were given high sensory scores.
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Emery, P., M. Ǿstergaard, L. C. Coates, A. Deodhar, E. Quebe-Fehling, P. Pellet, L. Pricop, C. Gaillez e F. Van den Bosch. "THU0373 SECUKINUMAB DOSE ESCALATION ON ACR RESPONSES IN ANTI-TUMOUR NECROSIS FACTOR NAÏVE PATIENTS WITH PSORIATIC ARTHRITIS: 2-YEAR DATA FROM THE PHASE 3 FUTURE 4 AND FUTURE 5 STUDIES". Annals of the Rheumatic Diseases 79, Suppl 1 (junho de 2020): 418.1–419. http://dx.doi.org/10.1136/annrheumdis-2020-eular.287.
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Background:Secukinumab (SEC) 150 and 300 mg doses are approved for the treatment of psoriatic arthritis (PsA). SEC 300 mg is the recommended dose for patients (pts) with concomitant moderate-to-severe plaque psoriasis or who are anti-tumour necrosis factor (TNF) inadequate responders. An increase from 150 mg to 300 mg has been reported to be beneficial in some patients with a suboptimal response to SEC 150 mg.1Here, we present a post hoc analysis in anti-TNF naïve pts who escalated from SEC 150 to 300 mg dose in two Phase 3 studies, FUTURE 4 (NCT02294227) and FUTURE 5 (NCT02404350).Objectives:To evaluate the clinical efficacy on joints following dose escalation from SEC 150 to 300 mg on ACR responses in anti-TNF naïve pts with PsA.Methods:Study design, patient inclusion and exclusion criteria of the FUTURE 4 and FUTURE 5 studies have been reported previously.1–3In FUTURE 4, 341 pts were randomised in a 1:1:1 ratio to SEC 150 mg with loading dose (LD), SEC 150 mg without LD, or placebo. In FUTURE 5, 996 pts were randomised in a 2:2:2:3 ratio to SEC 300 mg with LD, SEC 150 mg with LD, SEC 150 mg without LD or placebo. Following a protocol amendment, pts were allowed to escalate from 150 mg to the 300 mg dose, in the event of suboptimal response based on investigator’s judgment, starting at Week 36 in FUTURE 4 and at Week 52 in FUTURE 5. ACR responses in anti-TNF naïve pts were evaluated pre- and up to 32 and 40 weeks post-escalation, in FUTURE 4 and FUTURE 5, respectively: pts were grouped into four ranges based on their response: no (< 20); low (≥ 20 to < 50); moderate (≥ 50 to < 70); high (≥ 70) ACR responses. Data presented are as observed in the Sankey-style overlay plot.Results:Dose escalation from SEC 150 to 300 mg occurred in 136 pts in FUTURE 4 and in 236 pts in FUTURE 5. The proportion of ACR responders increased and the proportion of non-responders decreased in anti-TNF naïve pts who escalated from SEC 150 to 300 mg in the two studies. The proportion of anti-TNF naïve pts with a response ≥ACR50 increased from 20% to 41% in FUTURE 4 and 28% to 46% in FUTURE 5, post dose escalation. The ACR responses in anti-TNF naïve pts up to 40 weeks after escalation from SEC 150 to 300 mg are presented in the Sankey-style overlay (Figure).Figure.ACR Response bar chart with Sankey-style overlays up to 40 weeks, after dose escalation from SEC 150 mg to 300 mg, in anti-TNF naïve pts in FUTURE 4 and 5Conclusion:The proportion of ACR responders increased within 12-16 weeks and was sustained up to 40 weeks following dose escalation in anti-TNF naïve pts with PsA. These results suggest that dose escalation from SEC 150 to 300 mg may be beneficial in anti-TNF naïve pts with a suboptimal response on SEC 150 mg.References:[1]Kivitz AJ, et al. Rheumatol Ther. 2019;6(3):393–407;[2]Mease PJ, et al. Ann Rheum Dis. 2018;77:890–7;[3]Mease, P.J., et al. ACR Open Rheumatology. 2019 [ePub ahead of print] doi:10.1002/acr2.11097.Disclosure of Interests:Paul Emery Grant/research support from: AbbVie, Bristol-Myers Squibb, Merck Sharp & Dohme, Pfizer, Roche (all paid to employer), Consultant of: AbbVie (consultant, clinical trials, advisor), Bristol-Myers Squibb (consultant, clinical trials, advisor), Lilly (clinical trials, advisor), Merck Sharp & Dohme (consultant, clinical trials, advisor), Novartis (consultant, clinical trials, advisor), Pfizer (consultant, clinical trials, advisor), Roche (consultant, clinical trials, advisor), Samsung (clinical trials, advisor), Sandoz (clinical trials, advisor), UCB (consultant, clinical trials, advisor), Mikkel Ǿstergaard Grant/research support from: AbbVie, Bristol-Myers Squibb, Celgene, Merck, and Novartis, Consultant of: AbbVie, Bristol-Myers Squibb, Boehringer Ingelheim, Celgene, Eli Lilly, Hospira, Janssen, Merck, Novartis, Novo Nordisk, Orion, Pfizer, Regeneron, Roche, Sandoz, Sanofi, and UCB, Speakers bureau: AbbVie, Bristol-Myers Squibb, Boehringer Ingelheim, Celgene, Eli Lilly, Hospira, Janssen, Merck, Novartis, Novo Nordisk, Orion, Pfizer, Regeneron, Roche, Sandoz, Sanofi, and UCB, Laura C Coates: None declared, Atul Deodhar Grant/research support from: AbbVie, Eli Lilly, GSK, Novartis, Pfizer, UCB, Consultant of: AbbVie, Amgen, Boehringer Ingelheim, Bristol Myer Squibb (BMS), Eli Lilly, GSK, Janssen, Novartis, Pfizer, UCB, Speakers bureau: AbbVie, Amgen, Boehringer Ingelheim, Bristol Myer Squibb (BMS), Eli Lilly, GSK, Janssen, Novartis, Pfizer, UCB, Erhard Quebe-Fehling Shareholder of: Novartis, Employee of: Novartis, Pascale Pellet Shareholder of: Novartis, Employee of: Novartis, Luminita Pricop Shareholder of: Novartis, Employee of: Novartis, Corine Gaillez Shareholder of: Novartis, Employee of: Novartis, Filip van den Bosch Consultant of: AbbVie, Celgene Corporation, Eli Lilly, Galapagos, Janssen, Novartis, Pfizer, and UCB, Speakers bureau: AbbVie, Celgene Corporation, Eli Lilly, Galapagos, Janssen, Novartis, Pfizer, and UCB
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C, Revathi, e Vadivelu J. "HEPATOPROTECTIVE POTENTIAL OF PHYSALIS PERUVIANA L. FRUIT EXTRACTS ON LEAD ACETATE INTOXICATED RATS". Journal of Experimental Biology and Agricultural Sciences 9, n.º 3 (25 de junho de 2021): 353–61. http://dx.doi.org/10.18006/2021.9(3).353.361.
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Physalis peruviana has been widely used as a medicinal herb for treating various diseases since ancient times. This study aimed to examine the hepatoprotective potential of the ethanolic extract of P. peruviana fruit (EPPF) against lead acetate (LA) intoxicated male albino rats. The experimental rats were divided into ten groups of 4 animals. Animal of Group I served as normal, Group II animals were administered orally 15 mg/Kg body weight of LA, Group III to V animals received EPPF 150mg/kg, 300 mg/kg and 600 mg/kg respectively, Group VI animals received standard silymarin 50 mg/kg, and Group VII to X were treated with LA (15 mg/kg) with EPPF 150, 300, 600 and std 50 mg/kg, orally for 32 days respectively. The degree of protection was measured by estimating hematological parameters such as Hb, RBC, WBC, PCV, platelets, MCV, MCHC, and ESR and biochemical parameters such as urea, creatinine, Cholesterol, HDL, LDL, VLDL, bilirubin, SGOT, SGBT, ALP, GGT, protein, albumin and globulin. Lead acetate induced alterations of hematological and biochemical parameters were observed in group II animals and these levels brought back to normal in the animals treated with EPPF at the concentrations of 150, 300 and 600 mg/kg which was significantly similar to silymarin treated animals. The data of the results obtained depicted that the fruit extract of P. peruviana was found to have promising protective efficacy against lead acetate induced liver toxicity.
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Weingärtner, Roland, Oliver Erlenbach, Francisco De Zela, Albrecht Winnacker, Isabel Brauer e Horst P. Strunk. "Cathodoluminescence Measurements and Thermal Activation of Rare Earth Doped (Tb3+, Dy3+ and Eu3+) a-SiC Thin Films Prepared by rf Magnetron Sputtering". Materials Science Forum 527-529 (outubro de 2006): 663–66. http://dx.doi.org/10.4028/www.scientific.net/msf.527-529.663.
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We present comprehensive cathodoluminescence measurements from thin amorphous a- SiC films doped with rare earths. The a-SiC films were prepared by rf magnetron sputtering using a high purity SiC wafer in high purity argon atmosphere (5N, pressure approx. 0.2 mbar). The rare earth doping (Tb, Dy and Eu concentrations were below 2%) was performed by placing respective rare earth metal pieces of appropriate size onto the Silicon Carbide wafer. The rare earth ion emissions cover the colors green (Tb), yellow (Dy) and red (Eu). The optical and related structural properties of the films are correlated by means of high resolution transmission electron microscopy in combination with cathodoluminescence measurements in a scanning electron microscope. In addition, the corresponding compositions are determined by energy-dispersive x-ray analysis. The cathodoluminescence spectra of the rare earth 3+ ions are recorded in the visible at 20°C in the asgrown condition and after annealing treatments in the temperature range from 300°C to 1050°C by steps of 150°C. The anneal-related changes in the cathodoluminescence emission spectra and in the microstructure of the films are addressed. The SiC films show amorphous structure almost independent of the annealing treatment. Optimal annealing temperature for emissions of Tb3+ doped a-SiC were derived to be 600°C whereas Dy3+ and Eu3+ emissions increase at least up to 1050°C.
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Sieber, Jochen, Mark Weinheimer, Gail Kongable, Susan Riddle, Yung-Yeh Chang e Frank Flacke. "In Silico Examination of Initiation of Long-Acting Insulin Analogs Toujeo Compared to Lantus Under 3 Dosing Titration Rules in Virtual Type 2 Diabetes Subjects". Journal of Diabetes Science and Technology 14, n.º 5 (9 de julho de 2019): 898–907. http://dx.doi.org/10.1177/1932296819861586.
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Background: Despite the benefits and clinical necessity of insulin treatment in type 2 diabetes (T2D), healthcare providers are reluctant to initiate insulin, and patients are reluctant to start it for several reasons, one of these being the complexity of insulin treatment. Patients and their healthcare providers can benefit from titration algorithms (TAs) or rules that assist with the initiation and titration of insulin, performing the calculations that are needed to safely initiate and conservatively adjust. Methods: The primary objective for this in silico study was to examine the effectiveness of 3 dose TAs (1-3) for optimization of basal insulin glargine (Gla-100 and Gla-300). In the simulations, 100 virtual subjects with T2D were included (50% men, age 62 ± 3 years, HbA1c 8.1% ± 2.9%, body weight 94 ± 16 kg). Subjects were studied under each TA (TA1 and TA2 fasting blood glucose [FBG] targets 90-130 mg/dL, TA3 FBG target 110-150 mg/dL). Initial dose of both insulins was based on 0.2 U/kg body weight. During 3 months, subjects reported their FBG to the LTHome web-based dose guidance system with a rules engine to safely guide long-acting insulin titration and maintenance. Subjects followed dose recommendations to reach designated FBG target ranges. Results: All subjects reached stable doses under all TAs with both Gla-100 and Gla-300 insulin, and 93 or more of the 100 subjects, depending on the assigned TA, achieved the target FBG range within the 3-month simulation for all TAs. Mean FBG was lowered (Gla-100: 155 ± 40 to 118 ± 11 mg/dL with TA1 and TA2 and 132 ± 12 mg/dL for TA3; Gla-300: 125 ± 14 with TA1 and TA2 and 134 ± 15 mg/dL with TA3). Calculated HbA1c improved from 8.1% ± 2.9% to 7.1% ± 2.5% for TA1 and TA2 and 7.5% ± 2.5% for TA3, a reduction of 0.9% and 0.6% over 3 months for both insulins. Three subjects on Gla-100 and one subject on Gla-300 experienced mild hypoglycemia. Conclusion: All TAs delivered safe dose recommendations with minimal hypoglycemia, leading to a stable glucose control in the majority of subjects.
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Anwar, Syaiful, Edi Santosa e Purwono. "Cassava growth and yield on ultisol of different soil organic carbon content and NPK fertilizer levels". Jurnal Agronomi Indonesia (Indonesian Journal of Agronomy) 51, n.º 3 (23 de dezembro de 2023): 312–23. http://dx.doi.org/10.24831/jai.v51i3.47806.
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The demand for cassava tuber in Indonesia is high, however, domestic production is still limited therefore increasing production is important. Ultisol soils have the potential for cassava production, but low soil fertility in such soils needs to be improved. The research aimed to evaluate the effect of soil organic carbon (SOC) and NPK fertilizer on the growth and yield of cassava tuber in an ultisol. The experiment was conducted at the Jonggol Experimental Farm, IPB Bogor, West Java from September 2022 to January 2023. The experiment used a split-plot design with three replications. The main plot was SOC level of 1.93 (control), 2, 3, and 4%, and the subplot was NPK 15-15-15 level of 150, 300, 450, and 600 kg ha-1. SOC level was increased through the application of cow manure 0, 3.59, 54.93, and 106.27 tons ha-1 corresponding to SOC levels of 1.93 (control), 2, 3, and 4%, respectively. Results showed that enhancing SOC up to 3% and NPK 300 kg ha-1 were enough to support cassava growth as shown by plant height, stem diameter, and leaf number. The leaf number was the highest in the 3% SOC+150 kg NPK, 2% SOC+300 kg NPK or+450 kg NPK, and control+600 kg ha-1 NPK treatment. Leaf greenness was only affected by adding NPK fertilizer; a high greenness value was obtained at NPK level of > 150 kg ha-1 and 300 to 600 kg ha-1 resulting in non-significantly leaf greenness. The status of N and K in the leaves increased by SOC and NPK treatments, while the P status was unaffected. SOC at a level of 3% and NPK at a level of 150 kg ha-1 stimulated cassava to produce the highest fresh tuber weight (1.85 kg per plant) at 4 months after planting. Cassava productivity in ultisol soil can be increased by applying cow manure of 54.93 tons ha-1 to enhance SOC up to 3% combined with NPK of 150 kg ha-1.
Keywords: Extensification; food security; intensification; tuber production; nutrient uptake
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Idries, Abedalqader, Ismaail Ghaaowd e Murad Abu-Farsakh. "Effect of one cycle of heating-cooling on the clay-concrete pile interface behavior". E3S Web of Conferences 205 (2020): 05012. http://dx.doi.org/10.1051/e3sconf/202020505012.
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This study investigated the effect of applying one heating-cooling cycle on the interface strength parameters of saturated clay soil-concrete, and the potential use of the heating process to improve the side capacity of piles driven in clayey soil. A large direct shear test device with inner dimensions of 300 mm, 300 mm, and 200 mm for width, length, and height, respectively was modified to perform the interface soil-concrete tests. A concrete block (300 mm × 300 mm × 100 mm) was built and placed at the bottom section of the shear device. Watlaw heating fire rods system was used to heat the circulating water that heat the specimens. The experimental tests were conducted on Low Plasticity Index soil with PI=12. The specimens were first consolidated to a target normal stress prior to shearing. Two specimens at different testing temperature (room temperature = 20 °C, 70 °C) were tested for each of the four different normal stresses (30, 69, 110, and 150 kPa). The temperature for the heated specimens was increased gradually during the heating process from the room temperature (20 °C ± 2 °C) to 70 °C ± 2 °C in 3 hours. The specimens were then cooled back to room temperature. The test results showed significant increase in both peak and residual interface shear strength parameters by 13.6% and 15.6% increase in friction angle, respectively. Also, volumetric strain under shearing decreased after the heating and cooling cycle by 30.0%, 24.4%, 11.3%, and 24.2% under 30 kPa, 69 kPa, 110 kPa, and 150 kPa, respectively.
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Zepeda-Bautista, Rosalba, Juan Virgen-Vargas, Francisco Suazo-López, José L. Arellano-Vázquez e Miguel Á. Ávila-Perches. "NITRÓGENO EN FERTIRRIEGO PARA PRODUCIR SEMILLA DE LÍNEAS PROGENITORAS Y CRUZAS SIMPLES DE MAÍZ: DOSIS Y DISTRIBUCIÓN". Revista Fitotecnia Mexicana 44, n.º 2 (28 de junho de 2021): 191. http://dx.doi.org/10.35196/rfm.2021.2.191.
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El costo y el impacto al ambiente por aplicar fertilizante nitrogenado para producir semilla híbrida de maíz (Zea mays L.) son elevados y opuestos al desarrollo sustentable. La dosis, distribución y forma de aplicación son limitadas; por ello, se evaluó la aplicación del N en fertirriego y su efecto en el rendimiento de semilla en líneas y cruzas simples progenitoras de híbridos. En 2013 y 2014 se evaluaron las líneas M-54, M-55 y CML-242, las cruzas simples M-54×M-55 y M-55×M-54 y el híbrido H-70, con las dosis de N 150, 225 y 300 kg ha-1 en un diseño de bloques completos al azar. La distribución de las dosis 150, 225 y 300N-60P-30K se realizó durante el ciclo biológico. Las diferencias entre genotipos, dosis de N y años fueron significativas estadísticamente (P ≤ 0.01) para inicio de floración masculina (IFM) y femenina (IFF) y rendimiento de semilla. Hubo diferencias de 7 a 11 d entre M-54 y M-55 para IFM e IFF, y de 3 a 5 d entre M-54×M-55 y CML-242. Líneas y cruzas simples rindieron en promedio 3.28 y 8.44 Mg ha-1, respectivamente. Las dosis de 225 y 300 kg N ha-1 en fertirriego retrasaron el IFM e IFF en promedio entre 1 y 3 d, en comparación con 150 kg N ha-1, que tuvo un rendimiento promedio de 6.37 Mg ha-1. En 2013 el IFM e IFF aumentó en 4 y 2, d mientras que el rendimiento disminuyó en 3 % en comparación con 2014. La línea M-55 con 225 kg N ha-1 en 2013 rindió 25 % más que con 150 kg N ha-1. La aplicación de 150 kg N ha-1 en fertirriego incrementa la producción de semilla y las dosis de 225 y 300 kg ha-1 de N retrasan la floración.
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Nike Mustika Sari, Gede Iwan Setiabudi, Indah Mastuti e Ketut Mahardika. "The Effectiveness Of Citric Acid As An Anti-Ectoparasite Of Marine Leech (Zeylanicobdella arugamensis) Through Soaking". Advances in Tropical Biodiversity and Environmental Sciences 7, n.º 3 (29 de outubro de 2023): 106–12. http://dx.doi.org/10.24843/atbes.2023.v07.i03.p04.
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Zeylanicobdella arugamensis infection causes health problems for cultured grouper. This study aims to determine the effectiveness of citric acid soaking as an anti Z. arugamensis ectoparasite. A total of ±120 Z. arugamensis were isolated from sick hybrid grouper (Epinephelus fuscoguttatus x E. lanceolatus) placed in Petri dishes (6 Petri dishes). Citric acid solution with 0, 50, 100, 150, 250, and 400 ppm was added to the petri plates. Immersion of Z. arugamensis was carried out for 30, 60, 90 and 120 minutes. Each 30 Z. arugamensis/treatment/30 minutes was taken and placed in 3 petri dishes (10 individuals/petri dish) filled with seawater. Observations were made on the response of Z. arugamensis. Comments were made on cocoon development into larvae. The citric acid safety test was conducted on cantang hybrid grouper infected with Z. arugamensis. A total of 3 test fish were soaked with citric acid solution in seawater at concentrations of 0, 150, 250, and 300 ppm. Observations of fish condition were made after 30 and 60 minutes of immersion. The results showed that citric acid concentrations of 250 and 400 ppm effectively killed Z. arugamensis (76.67±15.28-100%), and their cocoon development reached (0%). A citric acid concentration of 300 ppm is still safe to use for immersion of cantang hybrid grouper infected with Z. arugamensis for 60 minutes. Citric acid concentrations of 250-300 ppm can also release Z. arugamensis from the fish body. Citric acid has antiparasitic properties and lowers the pH of seawater.
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Thorpy, Michael, Graham Eglit, Samantha Floam, Gregory Parks e Lois Krahn. "1023 Solriamfetol and Maintenance of Wakefulness Outcomes in Patients with Narcolepsy and Obstructive Sleep Apnea". SLEEP 47, Supplement_1 (20 de abril de 2024): A439—A440. http://dx.doi.org/10.1093/sleep/zsae067.01023.
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Abstract Introduction Patients with excessive daytime sleepiness (EDS) associated with narcolepsy or obstructive sleep apnea (OSA) struggle to maintain wakefulness. Solriamfetol (Sunosi®) is a dopamine/norepinephrine reuptake inhibitor with agonistic properties at TAAR1 and serotonin 1A receptors; it is approved to treat EDS associated with narcolepsy (75–150 mg/day) or OSA (37.5–150 mg/day). This post-hoc analysis characterized the effects of solriamfetol on the propensity of participants with EDS associated with narcolepsy or OSA to maintain wakefulness. Methods The safety and efficacy of solriamfetol has been evaluated in participants with EDS and narcolepsy or OSA in the phase 3 trials, TONES 2 and TONES 3. Participants were randomized to placebo or solriamfetol (37.5 mg [OSA only], 75 mg, 150 mg, or 300 mg) once daily for 12 weeks. This post-hoc analysis evaluated the proportion of participants who achieved improvement from baseline on various 40-minute Maintenance of Wakefulness Test (MWT) thresholds (≥5, ≥10, ≥15, and ≥20 minutes) and mean sleep latencies ≥30 and ≥40 minutes at weeks 1, 4, and 12. Comparisons between solriamfetol and placebo were evaluated using Fisher’s exact test. Results A greater proportion of participants with narcolepsy achieved improvement from baseline of ≥15 and ≥20 minutes on the MWT with solriamfetol 150 mg (36% and 18%, respectively) and 300 mg (38% and 28%) compared with placebo (4% and 4%) at week 12 (P≤0.028); findings were similar at week 12 in participants with OSA with solriamfetol 75 mg (28% and 13%), 150 mg (37% and 25%), and 300 mg (44% and 28%) compared with placebo (8% and 3%; P≤0.034). A greater proportion of participants with narcolepsy achieved MWT sleep latency ≥30 minutes at week 12 with solriamfetol 150 mg (24%) and 300 mg (30%) compared with placebo (2%; P≤0.002); results were similar in participants with OSA for MWT sleep latency ≥30 minutes at week 12 with solriamfetol 75 mg (28%), 150 mg (34%), and 300 mg (44%) compared with placebo (11%; P≤0.012). Conclusion These findings suggest solriamfetol leads to substantial improvements on objective propensity to stay awake in a large proportion of patients with narcolepsy or OSA when compared with placebo. Support (if any) Axsome Therapeutics, Jazz Pharmaceuticals
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Hong, David S., Peter J. Rosen, A. Craig Lockhart, Siqing Fu, Filip Janku, Razelle Kurzrock, Rabia Khan et al. "First-in-human study of AMG 208, an oral MET inhibitor, in adult patients (pts) with advanced solid tumors." Journal of Clinical Oncology 31, n.º 6_suppl (20 de fevereiro de 2013): 41. http://dx.doi.org/10.1200/jco.2013.31.6_suppl.41.
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41 Background: AMG 208 is a small molecule MET inhibitor that suppresses proliferation and induces apoptosis in human tumor xenografts. This first-in-human study evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics of AMG 208. We report data from the dose escalation part of the study. Methods: Key eligibility criteria: ≥ 18 yr, advanced solid tumors, ECOG ≤ 2, and evaluable/measurable disease. Using a modified Fibonacci design, 3–9 pts were enrolled into 1 of 7 sequential dose cohorts (25, 50, 100, 150, 200, 300, and 400 mg) of AMG 208. Pts received AMG 208 orally on days 1 and 4–28 once daily. If no dose limiting toxicity (DLT) was seen on days 1–28, pts received AMG 208 once daily starting at day 36 provided pts showed no evident disease progression. In cohorts 1–3, a standard 3+3 design was followed. In cohorts 4–7, a modified 3+3+3 design was followed. Results: As of July 16 2012, 54 pts (25 mg [n=6], 50 mg [n=4], 100 mg [n=4], 150 mg [n=3], 200 mg [n=16], 300 mg [n=10], and 400 mg [n =11]) had received ≥ 1 dose of AMG 208. 67% were men; 19% had prostate cancer (PC). Median (range) age: 61 (39–80) yr. ECOG 0/1: 52%/48%. 6 DLTs were seen: a grade (G) 3 increased AST (200 mg), a G3 thrombocytopenia (200 mg), a G4 acute myocardial infarction (300 mg), a G3 prolonged QT (300 mg), and two G3 hypertensions (400 mg). The maximum tolerated dose was not reached. 83% of pts had tx-related adverse events (AE). Tx-related AE occurring in > 10 pts: fatigue (n=24), nausea (n=18), hypertension (n=12), and diarrhea (n=11). 24% of pts had grade ≥ 3 tx-related AE. AMG 208 was orally bioavailable with a 30–35 hr mean half-life in plasma. Exposure increased linearly with dose; accumulation at day 28 was 2.7-fold across cohorts. Of the 42 pts with available tumor response data for site reads, 1 had complete response on bone scan (PC 300 mg) while 2 had partial responses (PR; PC 400 mg and kidney cancer 200 mg; both had -33% tumor shrinkage), and 29 had stable disease (SD); 1 other PC pt had PR after data cutoff. Of the 35 pts with available tumor response data for central reads, 26 had SD. FLT and biomarker data will be presented. Conclusions: AMG 208 up to 400 mg daily had manageable toxicities and showed evidence of antitumor activity, especially in prostate cancer. Clinical trial information: NCT00813384.
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Lu, Rui, Xiaoling Zhong, Shiguang Shang, Shan Wang e Manling Tang. "Effects of sintering temperature on sensing properties of WO 3 and Ag-WO 3 electrode for NO 2 sensor". Royal Society Open Science 5, n.º 10 (outubro de 2018): 171691. http://dx.doi.org/10.1098/rsos.171691.
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Pure WO 3 and Ag-WO 3 (mixed solid solutions Ag with WO 3 ) have been successfully synthesized by sol-gel method and the influences of calcination temperature on the particle size, morphology of the WO 3 and Ag-WO 3 nanoparticles were investigated. Powder X-ray diffraction results show that the hexagonal to monoclinic phase transition occurs at calcination temperature varying from 300°C to 500°C. SEM images show that calcination temperature plays an important role in controlling the particle size and morphology of the as-prepared WO 3 and Ag-WO 3 nanoparticles. The NO 2 gas sensing properties of the sensors based on WO 3 and Ag-WO 3 nanoparticles calcined at different temperatures were investigated and the experimental results exhibit that the gas sensing properties of the Ag-WO 3 sensors were superior to those of the pure WO 3 . Especially, the sensor based on Ag-WO 3 calcined at 500°C possessed larger response, better selectivity, faster response/recovery and better longer-term stability to NO 2 than the others at relatively low operating temperature (150°C).
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Panahi, H., M. Bouyeh, D. Behzadpour, A. Seidavi, J. Simões, Vincenzo Tufarelli, V. N. Staffa, A. Tinelli, T. Ayasan e V. Laudadio. "Effect of dietary simvastatin and L-carnitine supplementation on blood biochemical parameters, carcass characteristics and growth of broiler chickens". Journal of the Indonesian Tropical Animal Agriculture 44, n.º 4 (28 de dezembro de 2019): 372. http://dx.doi.org/10.14710/jitaa.44.4.372-381.
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The aim of this study was to evaluate the effect of simvastatin (SIM) and L-carnitine (LC) additives and their interactions, on productive performance and carcass quality of broilers. For this purpose, a feeding trial was conducted, under 3×3 factorial design, using SIM at 0, 1 or 2 g/kg level and LC at 0, 150 or 300 mg/kg level in a basal-diet and originating a total of nine treatments: T1 (control-diet, 0/0), T2 (0/150), T3 (0/300), T4 (1/0), T5(1/150), T6 (1/300), T7 (2/0), T8 (2/150), and T9 (2/300). Feed intake was higher in T2 (4716 g), T7 (4722 g) and T9 (4698 g) than in T1 (4545 g; P<0.05) considering the last growing phase (35-42 days) or whole 42-day production cycle. An improvement of feed efficiency was also observed in T8 (1.64) and T9 (1.67) when compared to T1 (1.77; P<0.05), and these were mainly due to SIM × LC interactions (P<0.05). The LC influenced positively (P<0.05) the weight of eviscerated carcass, breast, drumsticks and abdominal fat, as well as plasma triglycerides level. This findings suggests that the combination of SIM and LC additives have a positive influence on growth performance and carcass traits of broiler chickens.
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Widayati, Eni, Taufiqurrachman Nasihun, Azizah Hikma Savitri e Nurina Tyagita. "Comparison of Bax and Caspase-3 Protein Expression in Liver Cells following UVB Irradiation for 7 days and Treatment of Pimpinella alpina Molk during 7 and 15 days". Bangladesh Journal of Medical Science 19, n.º 2 (16 de janeiro de 2020): 296–303. http://dx.doi.org/10.3329/bjms.v19i2.45011.
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Objective: The effect of Pimpinela alpina Molk (PaM) on decrease in Bax and Caspase-3 protein expression in liver cells apoptosis have been proven. However, the difference result between 7 and 15 days treatment duration of PaM need to be confirmed. This study aimed to confirm that treatment of PaM during 15 days is more effective decreasing Bax and Caspase-3 protein expression in liver cells following UVB irradiation.
Methods: In the post test only control group design, 35 Sprague Dawley male rats, 300 gram body weight were divided into two arms, consisting of three groups respectively. First arm comprise Neg-7, PaM7-100, and PaM7-150. Second arm comprise Neg-15, PaM15-100, and PaM15-150. Nor-G was added as normal control neither exposed to UVB nor PaM treatment. In negative group was only radiated to UVB and PaM groups were exposed to UVB and treatment with 100, and 150 mg PaM per oral for 7 and 15 days respectively. At day 8 (first arm) and 16 (second arm), liver organ was taken and Bax and Caspase-3 protein expression assessed by Immunohistochemical staining method.
Result: Post Hoc LSD analysis indicated that Bax and Caspase-3 protein expression in PaM15-100 and PaM15-150 was significant lower compared to that of Nor-G, PaM7-100, and PaM7-150, p < 0.05.
Conclusion: Ttreatment of PaM with doses 100 and 150 mg for 15 days was better in decreasing Bax and Caspase-3 protein expression of liver cells following UVB irradiation.
Bangladesh Journal of Medical Science Vol.19(2) 2020 p.296-303
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Yi, Jung Woo, Hyun Pyo Hong, Myung Sub Kim, Byung Seok Shin, Heon-Ju Kwon, Byung Ik Kim e Won Sohn. "Comparison of Clinical Efficacy and Safety between 70–150 µm and 100–300 µm Doxorubicin Drug-Eluting Bead Transarterial Chemoembolization for Hepatocellular Carcinoma". Life 12, n.º 2 (16 de fevereiro de 2022): 297. http://dx.doi.org/10.3390/life12020297.
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Background: This study aimed to compare the efficacy and safety of 70–150 μm doxorubicin drug-eluting bead (DEB) transarterial chemoembolization (TACE) with those of 100–300 μm DEB-TACE as first-line treatment in patients with hepatocellular carcinoma (HCC). Methods: We retrospectively investigated 72 patients who underwent TACE with 70–150 μm DEBs (n = 40) or 100–300 μm DEBs (n = 32) for HCC in a tertiary center between March 2013 and May 2019. Initial treatment response and adverse events were assessed using the modified Response Evaluation Criteria in Solid Tumors and the National Cancer Institute Common Terminology Criteria for Adverse Events version 5.0, respectively. Results: At the 2-month post-treatment assessment, the complete and objective response rates were 47.5% and 85.0%, respectively, for the 70–150 μm group and 34.4% and 81.3%, respectively, for the 100–300 μm group; however, the difference was not statistically significant (p > 0.05). In total, 65% patients in the 70–150 μm group and 59.4 % patients in the 100-300 μm group experienced at least one symptom of post-embolization syndrome after TACE; all symptoms were classified as grade 1 or 2. There was no significant difference between the two groups in terms of post-procedural laboratory changes such as changes in liver enzymes and bilirubin levels (p > 0.05). Laboratory toxicity of grade 3 occurred in three patients, all of which were transient elevation of liver enzyme levels. Hepatobiliary adverse events, such as bile duct injury, biloma, liver abscess, and hepatic infarction, were not observed in either treatment group. Conclusion: This study found no significant difference in tumor response between 70–150 μm and 100–300 μm DEB-TACE. Both groups showed favorable safety profiles, and the difference was not significant.
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Habib, Amir, Nils Stelzer e Roland Haubner. "Fabrication of BaTiO3-PMMA Polymer Nanocomposite Thin / Thick Films and their Dielectric Properties". Solid State Phenomena 151 (abril de 2009): 108–12. http://dx.doi.org/10.4028/www.scientific.net/ssp.151.108.
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Thin and thick BaTiO3-polymer nanocomposite dielectric films were prepared using BaTiO3 nanoparticles and poly (methyl methacrylate) (PMMA). The cubic BaTiO3 (~ 30-60 nm) and tetragonal BaTiO3 (~ 120 nm) synthesized via hydrothermal/solvothermal route were used as nanofillers. The dielectric constant of 9 was achieved for the films of thicknesses in the 150-300 nm range, which corresponds to a capacitance density of 32 nF/cm2. The dissipation factor of the composite film was of a value of 0.04 at 10 kHz. Thick films (~ 16.3 µm) were prepared by doctor blade method and tested for their capacitance and dielectric properties in the 10-100 kHz frequency range for cubic and tetragonal BaTiO3. The BaTiO3 particles were dispersed homogeneously in the films at lower filler loading. The homogenous distribution of BaTiO3 achieved by surface functionalization of BaTiO3 nanoparticles and use of tetragonal BaTiO3 resulted in the improvement of electric properties of thick and thin films.
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Quranayati, Quranayati. "Maternal Mortality Care / 3 Overdue 4 Overly". Review of Primary Care Practice and Education (Kajian Praktik dan Pendidikan Layanan Primer) 5, n.º 1 (9 de março de 2022): 25. http://dx.doi.org/10.22146/rpcpe.69543.
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Preeclampsia is a hypertensive condition that occurs in pregnant women whose gestational age has reached 20 weeks or after delivery who previously had normal blood pressure and increased to 140/90 mmHg or more. Preeclampsia condition is a vasospastic disease that involves many systems and is characterized by hemoconcentration, hypertension, and proteinuria >300 mg/24 hours. These symptoms can be seen during pregnancy, childbirth and in the puerperium which can be accompanied by convulsions and coma. Preeclampsia is one of the causes of maternal and perinatal mortality, and can be detected at gestational age >34 weeks with blood pressure < 140 /110 mmHg, then the patient may have preeclampsia.
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Manengkey, Swingly Fidelik, Ferdy A. Karauwan, Amal R. Ginting e Silvana L. Tumbel. "Uji Efektivitas Ekstrak Bunga Pepaya Jantan Carica papaya L. Sebagai Analgesik Terhadap Tikus Putih Rattus norvegicus". Biofarmasetikal Tropis 3, n.º 1 (30 de abril de 2020): 1–5. http://dx.doi.org/10.55724/j.biofar.trop.v3i1.248.
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Ekstrak bunga pepaya jantan (Carica papaya L) dengan dosis 75 mg/kgBB, 150 mg/kgBB dan 300 mg/kgBB, kontrol positif (Paracetamol), dan kontrol nergatif (Na CMC) telah dilakukan uji sebagai analgesik terhadap tikus putih. Perlakuan diberikan terhadap tikus yang sudah diinduksi panas menggunakan water bath dengan suhu 53,5°C selama kurang lebih 1 menit. Tikus percobaan dibagi menjadi 5 kelompok perlakuan dengan 3 kali pengulangan. Hasil penelitian selama 120 menit menunjukkan bahwa ekstrak bunga pepaya jantan dengan dosis 75 mg/kgBB. 150 mg/kgBB dan 300 mg/kgBB menunjukkan efektivitas sebagai analgesik dengan adanya penurunan geliat pada tikus percobaan, dimana penurunan paling baik ditunjukkan oleh ekstrak dengan dosis 300 mg/kgBB. Hal ini disebabkan karena ekstrak bunga pepaya mengandung flavonoid dan tanin yang berperan sebagai analgesik dengan cara menghambat enzim siklooksigenase, sehingga pembentukan prostaglandin penyebab nyeri oleh asam arakidonat terhambat.
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Rivard, N., G. Rydzewska, J. S. Lods, J. Martinez e J. Morisset. "Pancreas growth, tyrosine kinase, PtdIns 3-kinase, and PLD involve high-affinity CCK-receptor occupation". American Journal of Physiology-Gastrointestinal and Liver Physiology 266, n.º 1 (1 de janeiro de 1994): G62—G70. http://dx.doi.org/10.1152/ajpgi.1994.266.1.g62.
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Cholecystokinin (CCK), CCK octapeptide (CCK-8), and caerulein (Cae) are the most potent trophic factors in the pancreas when given exogenously or released from the intestine. Recent studies have suggested that this growth-promoting effect of CCK was initiated through the occupation of the CCKA receptor. This study was then undertaken to determine whether occupation of the high- or low-affinity CCKA receptor is involved in the growth process and to establish which transduction signals have been selectively activated. As an answer to the first question, rats were infused with CCK JMV-180, a CCKA high-affinity agonist, at doses of 50, 100, 150, and 300 micrograms.kg-1.h-1, or Cae (0.25 micrograms.kg-1.h-1) for 4 days. After rats were killed, their pancreatic weight and contents of protein, DNA, RNA, amylase, and chymotrypsinogen were estimated. To investigate the transduction signals, rats were infused for 30 min to 4 h with 300 micrograms.kg-1.h-1 JMV-180, or pancreatic acini were exposed in vitro to 1 microM JMV-180 for 5 or 30 min. After rats were killed, pancreases were used to monitor tyrosine kinase, phosphatidylinositol (PtdIns) 3-kinase, and phospholipase D (PLD) activities. The first set of experiments indicates that JMV-180 caused a dose-dependent effect on pancreas growth, with the 300 micrograms.kg-1 x h-1 dose giving the maximal effect comparable to that of Cae. Furthermore, JMV-180 induced concomitant early increases in tyrosine kinase and PLD activities both in vivo and in vitro and PtdIns 3-kinase in vitro.(ABSTRACT TRUNCATED AT 250 WORDS)
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Gangannavar, Ayyanagouda A., Raghu G., Mahendra S. V., Manoj Kumar B. K. e Umesh Rajoor. "Prevalence of thyroid abnormalities in HIV/AIDS persons and correlation with CD4 count, HAART drug and duration of illness". International Journal of Advances in Medicine 7, n.º 8 (21 de julho de 2020): 1264. http://dx.doi.org/10.18203/2349-3933.ijam20203126.
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Background: Human immunodeficiency virus (HIV) infection is characterized by decrease in CD4 cell count and immunodeficiency, leading to opportunistic infections (OIs) and tumors. Objective of this study was to find out any association between thyroid function abnormality and CD4 count, duration of disease and ART drugs.Methods: Among 300 HIV/AIDS Persons attending ART centre, M.Y. Hospital, or attending general OPD, or admitted as in patients Dept. of Medicine, MGM Medical College and M.Y. Hospital, Indore, India.Results: Amongst 300 HIV patients,62 (20.66%) had thyroid dysfunction, most common being subclinical hypothyroidism (24/300, 8.0%) followed by sick euthyroid (17/300, 5.6%) and subclinical hyperthyroidism (13/300, 4.3%). Overt hypothyroidism was present in 5 of 300 (1.66%) patients and overt hyperthyroidism was present in 3 of 300 (1.0%) patients. 25 of 152 (16.44%) and 37 of 148 (25%) male and female HIV patients had thyroid function abnormality. Thyroid dysfunction was significantly more observed in old HIV patients (42/150, 28.0%) than in newly diagnosed HIV patient’s group (20/150, 13.33%).Conclusions: This prevalence being fairly high, it can be suggested that all retro positive patients, recently diagnosed and on treatment also may be subjected for routine thyroid function testing.
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Lin, Xu Ping, Jing Tao Ma, Bao Qing Zhang e Qiang Lin. "Effect of Al2O3 on the Phase Stability of Y-Ce-TZP/Al2O3 Composites at Low Temperature". Key Engineering Materials 336-338 (abril de 2007): 1190–93. http://dx.doi.org/10.4028/www.scientific.net/kem.336-338.1190.
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The mechanical properties and the phase stability in yttria and ceria stabilized zirconia containing 0-20wt% A12O3 during aging in air (300°C) and in water vapor (150°C, 180°C, 200°C and 250°C) are investigated in this paper. It is found that water can greatly accelerate the degradation of Y-Ce-TZP. The addition of Al2O3 to Y-Ce-TZP prevents the low temperature degradation in air. Also Al2O3 particles can restrain the phase transformation of tetragonal to monoclinic in Y-Ce-TZP under water vapor condition when the temperature is below 200°C.