Gotowa bibliografia na temat „Zhao gu cheng hui guan”

Abstract Background: Intratumor heterogeneity (ITH) refers to variations observed among cancer cells within a single tumor, posing significant challenges in clinical practice due to its contribution to treatment resistance and unfavorable outcome. However, the inconvenience of multi-region biopsy and limitations of genomic sequencing based on limited tissue impede the practical detection of ITH. Consequently, there is an urgent need for a non-invasive method that comprehensively captures ITH from a holistic perspective of the entire tumor. Methods: We utilized a large multicenter dataset comprising dynamic contrast-enhanced magnetic resonance images from breast cancer patients (n = 1423) along with matched multiomics data (n = 468) to develop a non-invasive machine learning approach for measuring ITH. We extracted quantitative radiomic features from both the entire tumor and peritumor regions, with a specific focus on features associated with imaging heterogeneity. Using these radiomic features, we established an imaging ITH (IITH) model. The robustness of IITH evaluation was determined by assessing its correlation with genomic ITH (employing the mutant-allele tumor heterogeneity [MATH] algorithm) and pathological cellular ITH (analyzing variation in quantitative nuclear features extracted through digital pathology). Prognostic power was evaluated using Kaplan-Meier and multivariate Cox proportional hazards analyses. Integrated multiomics analyses were performed to investigate the molecular basis of different IITH subgroups. Results: We developed a non-invasive radiomic signature to quantify imaging ITH (IITH) in the FUSCC cohort. Breast cancer patients were retrospectively categorized into high and low IITH groups. Multivariate Cox analysis identified high IITH as an independent predictor of poor prognosis in breast cancer patients, even after adjusting for clinical risk factors such as tumor size, positive lymph nodes, clinical subtype and lymphovascular invasion status. These findings were further validated in the DUKE cohort, confirming the prognostic value of IITH. Moreover, we substantiated the robustness of IITH by demonstrating its association with genomic and pathological ITH. Multiomics analysis revealed the activation of oncogenic pathways and metabolic dysregulation in high-IITH tumors. Intriguingly, our investigation also highlighted ferroptosis as a vulnerability and potential therapeutic target in high-IITH tumors, which was further supported by evidence from the TCGA cohort. Conclusion: Radiomic-based assessment of ITH provides a non-invasive approach to comprehensively capture ITH and predict the prognosis of breast cancer patients. Targeting ferroptosis may hold promise as a treatment strategy for patients with high IITH. Citation Format: Guan-Hua Su, Yi Xiao, Chao You, Ren-Cheng Zheng, Shen Zhao, He Wang, Yi-Zhou Jiang, Ya-Jia Gu, Zhi-Ming Shao. Radiogenomic-based imaging intratumor heterogeneity model predicts breast cancer prognosis and unveils therapeutic targets [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO1-07-11.

BACKGROUND: Hypertension has become one of the most pathogenic diseases in the world. OBJECTIVE: This paper summarizes and analyzes the acupuncture point combinations and treatment principles of acupuncture for hypertension in a systematic way by means of big data mining. METHODS: The literature for this paper was obtained from CNKI, Wanfang, VIP, SinoMed and PubMed, Embase, Cochrane Library, Web of Science, and Ovid databases. Thedata were collected to obtain combinations of acupoints with strong associations through association rule analysis, complex networks for screening to obtain core acupoint nuclei, and cluster analysis to derive treatment principles. RESULTS: A total of 127 acupuncture prescriptions involving 66 acupoints were included in this study. Tai-chong (LR3), Qu-chi (LI11), Zu-san-li (ST36), Feng-chi (GB20), and He-gu (LI4) were the most commonly used acupoints. The large intestine meridian was the preferred meridian, and most of the extremity acupoints, especially the lower extremities, were selected clinically. The association rule reveals that Qu-chi (LI11) and Zu-san-li (ST36) are the dominant combination acupoints. 3 core association points obtained after complex network analysis, the 1st association, Bai-hui (DU20), Tai-xi (KI3), Gan-shu (BL18), Shen-shu (BL23); The 2nd association, Qu-chi (LI11), He-gu (LI4), San-yin-jiao (SP6), Zu-san-li (ST36), Feng-chi (GB20), Tai-chong (LR3); The 3rd association, Qi-hai (RN6), Guan-yuan (RN4), Zhong-wan (RN12), Zhao-hai (KI6), Tai-yang (EX-HN5), Lie-que (LU7), Yang-ling-quan (GB34), Xing-jian (LR2), Yin-ling-quan (SP9). Cluster analysis yielded the treatment principles of nourishing Yin and submerging Yang, pacifying the liver and submerging Yang, tonifying Qi and Blood, and calming the mind and restoring the pulse, improving clinical outcomes. CONCLUSION: By means of big data mining, we can provide reference for acupuncture point grouping and selection for clinical acupuncture treatment of hypertension.

LANGUAGE NOTE | Document text in Chinese; abstract also in English. 本文考訂楊伯峻《春秋左傳注》（以下簡稱《左傳注》），以《左傳》成公二年爲範圍，討論“無能爲役”“詰朝”、“朝食”、“大户”四則。經詞例分析，“無能爲役”之“役”當爲名詞，應從《左傳》襄公十七年《春秋左傳集解》（以下簡稱《集解》）釋爲“役事”，較《左傳注》解作“僕役”適洽。《左傳》四見“詰朝”，《集解》於三處釋“平旦”、一處釋“明朝”，《左傳注》解作明日早晨。本文讀“詰”爲“佶”而訓爲“正”，先秦典籍“正”字常有“平”義；至於“朝”與“旦”皆有“早”義，故“詰朝”即“平旦”。《左傳注》謂“朝食”爲早上進食，《史記》則將“朝食”寫爲“會食”。然就《左傳》載齊頃公“余姑翦滅此而朝食”語，顯是自認可在早上結束戰争，故“朝食”仍應解爲在早上進食。《集解》釋“大户”爲“閲民户口”而《左傳注》解作“清理户口”，“大户”之“大”應讀爲“汏”。《説文》謂“汏”字本義爲“淅㶕”，即後世所謂淘洗，沙汏、淘汏皆自“汏”字本義引申。從另一角度言，“淅㶕”亦有清理、計算義；且《左傳》“閲”字亦有“計算”義，故《集解》釋“大户”爲“閲民户口”即計算户籍，乃讀“大”爲“汏”。 This article examines four phrases in Yang Bojun’s Commentary on the Zuo Tradition of the Spring and Autumn Annals (hereafter Yang’s Commentary), namely “wu neng wei yi” 無能爲役, “jie chao” 詰朝, “zhao shi” 朝食, and “da hu” 大户, which are found in the second year of Duke Cheng of Lu (589 B.C.) in the Zuozhuan. According to the analysis of a register of example phrases, the word “yi” in the phrase “wu neng wei yi” should be regarded as a noun, which refers to “service matter” as seen in Duke Xiang 17 in Collective Exegeses on the Zuo Tradition of the Spring and Autumn Annals (hereafter, Collective Exegeses). This reading makes more sense than Yang’s Commentary, in which the word is glossed as “servant.” The phrase “jie chao” occurs four times in Zuozhuan. In Collective Exegeses it is glossed as “dawn” three times and as “the next morning” once. In Yang’s Commentary, however, all four occurrences are glossed as “the next morning.” The present article reads “jie” 詰 as “ji” 佶 and glosses it as “zheng” 正 (“the horizon”). In pre-Qin texts, the character “zheng” often carries the meaning of “the horizon.” The characters “chao” and “dan” both mean “dawn.” Therefore, the phrase “jie chao” refers to “dawn.” In Collective Exegeses, the phrase “zhao shi” is glossed as “eating a meal in the morning.” In the Shiji, “zhao shi” is written as “hui shi” 會食; however, the Zuozhuan records a sentence said by Duke Qing of Qi, “Yu gu jian mie ci er zhao shi” 余姑翦滅此而朝食, which clearly refers to a statement to himself that the battle could be over in the morning. Therefore, “zhao shi’ should still be understood as “eating a meal in the morning.” The Collective Exegeses glosses the phrase “da hu” as to “check on” (“yue” 閲) household occupants, while Yang’s Commentary glosses it as “canceling one’s residence registration.” Therefore, “da” should be read as “tai” 汏. According to the Shuowen, the original meaning of “tai” is “to wash in a pan or basket” (“xi jian” 淅㶕); referring to weeding out something/someone in today’s parlance. Moreover, several other phrases such as “sha tai” 沙汰 and “tao tai” 淘汰 were derived from the same original meaning. From another angle, the phrase “xi jian” also carries the meanings of “checking” or “calculating.” In the Zuozhuan, the word “yue” also means “calculating”; therefore, the phrase “da hu” means “checking on (“yue”) the household occupants or, in other words, to calculate household registries. The word “da” should be read as “tai”.

Graphene-based composites have received a great deal of attention in recent year because the presence of graphene can enhance the conductivity, strength of bulk materials and help create composites with superior qualities. Moreover, the incorporation of metal oxide nanoparticles such as Fe3O4 can improve the catalytic efficiency of composite material. In this work, we have synthesized a composite material with the combination of reduced graphene oxide (rGO), and Fe3O4 modified tissue-paper (mGO-PP) via a simple hydrothermal method, which improved the removal efficiency of the of methylene blue (MB) in water. MB blue is used as the model of contaminant to evaluate the catalytic efficiency of synthesized material by using a Fenton-like reaction. The obtained materials were characterized by SEM, XRD. The removal of materials with methylene blue is investigated by UV-VIS spectroscopy, and the result shows that mGO-PP composite is the potential composite for the color removed which has the removal efficiency reaching 65% in acetate buffer pH = 3 with the optimal time is 7 h. Keywords Graphene-based composite, methylene blue, Fenton-like reaction. References [1] Ma Joshi, Rue Bansal, Reng Purwar, Colour removal from textile effluents, Indian Journal of Fibre & Textile Research, 29 (2004) 239-259 http://nopr.niscair.res.in/handle/123456789/24631.[2] Kannan Nagar, Sundaram Mariappan, Kinetics and mechanism of removal of methylene blue by adsorption on various carbons-a comparative study, Dyes and pigments, 51 (2001) 25-40 https://doi.org/10.1016/S0143-7208(01)00056-0.[3] K Rastogi, J. N Sahu, B. C Meikap, M. 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