Artykuły w czasopismach na temat „You Shu shu gao”
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Bashkeev, Victor V. "Han Documents Preserved in the First Chapter of the Han Shu: Distribution Structure and Reflection of the Political Process". China: society and culture 1, nr 1 (10.06.2022): 65–78. http://dx.doi.org/10.17816/ch81802.
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This article discusses four types of documents being preseved in the second part of the first chapter (1B) of the Han shu (The History of Han) [1], the main source for the history of the Western Han state (202 BC 8 AD). The Han shu 1B chapter covers the period from 202 to 195 BC. the reign of the first emperor of the new Liu dynasty, Liu Bang, better known as Gao-zu. The article examines the distribution structure, content and the role of documents preserved in the text of the Han shu 1B chapter and singled out by the author as independent structural elements of the chapter, along with chronicle reports, historical reports, historical narratives and dialogs in the reflection of the historical reality. These are documents of higher bureaucratic turnover of varying degrees of importance. The analysis of the dynamics of document distribution in the text of the Han shu chapter 1B allowed to establish the fact of increased activity of Emperor Liu Bang in the sphere of administration in the penultimate year of his reign at the very beginning of the transition from the forceful subjugation of political opponents to the peaceful administration of the power he was creating.
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Nivison, David S. "An Interpretation of the “Shao Gao”". Early China 20 (1995): 177–93. http://dx.doi.org/10.1017/s0362502800004478.
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This article presents a new translation of the “Shao gao” chapter of the Shang shu. Contrary to the views of Edward Shaughnessy in Early China 18, the author argues 1) that the main speaker is the Duke of Zhou, not the Duke of Shao; 2) that the political philosophy expressed is consistent with other texts ascribed to the Duke of Zhou; and 3) that the Duke of Zhou did not die in disgrace or in exile. The author dates the Duke of Zhou's death to the twenty-first year of King Cheng's reign, either 1017 or 1015 B.C.
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Bingquan, Li, i Chen Zhengyang. "On the Psychological Therapy of Zhu-You-Shu". Theory and Practice of Psychological Counseling 6, nr 6 (2024): 279–87. http://dx.doi.org/10.35534/tppc.0606035.
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Rudenko, N. V. "“Interpretation of Voidness and Fullness” and “Interpretation of Loftiness and Cleanliness”: Li Zhi’s Essays on the Qualities of Human Character". Orientalistica 3, nr 1 (29.03.2020): 84–109. http://dx.doi.org/10.31696/2618-7043-2020-3-1-84-109.
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The paper continues the research of the chapter “Diverse Writings” (Za shu 雜述) of the famous “Book to Burn” (Fen shu 焚書), opus magnum of iconoclastic late Ming thinker Li Zhi (李贄, 1527–1602), and presents the first Russian translations of Li Zhi’s essays on qualities of human character: “Interpretation of Voidness and Fullness” (Xu shi shuo 虛實說) and “Interpretation of Loftiness and Cleanliness” (Gao jie shuo 高潔說). In these writings the thinker makes accent on the importance of real, not only nominal possession of virtues as well as of the ability to reconsider one’s own wrong views. He also protests against the hypocrisy and prejudice and puts forward the genuineness as a criteria of what makes the difference between ordinary people and a gentleman. The essays provide a bright reflection of the core features of Li Zhi’s philosophical views, such as oppositional authentism, naturalistic dualism and the synthesis of Buddhist, Daoist and Confucian elements.The author declares that there is no conflict of interest.
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Sun (孫飛燕), Feiyan. "On the Nature of the Tsinghua Bamboo-Slip Manuscript Chi jiu zhi ji Tang zhi wu". Bamboo and Silk 4, nr 2 (1.09.2021): 246–70. http://dx.doi.org/10.1163/24689246-00402011.
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Abstract The nature of the Tsinghua bamboo-slip manuscript Chi jiu zhi ji Tang zhi wu is different from that of the Yi Yin shuo, which is recorded in the ‘Zhuzi lüe’ of the Han shu ‘Yiwen zhi’. This manuscript is also not a story fabricated by people in the Warring States period. It is possible that what is presented in this manuscript was a legend passed from generation to generation within Yi Yin’s lineage. Unlike Yin zhi and Yin gao, this manuscript does not belong to the Shangshu category.
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Lazerick, Beth. "News from the Net: Montessori Mathematics". Teaching Children Mathematics 6, nr 8 (kwiecień 2000): 501. http://dx.doi.org/10.5951/tcm.6.8.0501.
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For Montessori teachers and for those of you who may just be interested in learning about the Montessori method of teaching mathematics, Shu-Chen Jenny Yen's Online Montessori Albums is a wonderful site to explore.
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Yin, Xin, Rie Kishida, Sarah Krull Abe, Md Rashedul Islam, Md Shafiur Rahman, Eiko Saito, Qing Lan i in. "Abstract 4200: Association between reproductive factors with lung cancer incidence and mortality: A pooled analysis of over 308,000 females in the Asia Cohort Consortium". Cancer Research 83, nr 7_Supplement (4.04.2023): 4200. http://dx.doi.org/10.1158/1538-7445.am2023-4200.
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Abstract Background: Previous studies have investigated the association between reproductive factors and lung cancer risk; however, findings have been inconsistent. This study aims to assess the association between reproductive factors with lung cancer incidence and mortality among Asian women. Methods: A total of 308,949 female participants with a mean age of 55.13 from 11 prospective cohorts and four Asian countries (Japan, Korea, China, and Singapore) in the Asia Cohort Consortium (ACC) were included. Cox proportional hazards regression models were used to estimate the hazard ratios (HR) and 95% confidence intervals (CIs). Results: A total of 3,119 primary lung cancer cases and 2,247 lung cancer deaths were identified with a mean follow-up of 16.4 years. Parous women had a lower risk of lung cancer incidence and mortality as compared with nulliparous women, with HRs of 0.82 (95% CI = 0.70 - 0.96) and 0.78 (95% CI = 0.65 - 0.94). Corresponding HRs were lowest among women with 1-2 children, with HRs of 0.78 (95% CI = 0.66 - 0.93) and 0.72 (95% CI = 0.59 - 0.87) for lung cancer incidence and mortality. The protective association of parity and lung cancer incidence was greater among ever-smokers (HR=0.66, 95% CI = 0.49 - 0.87) than in never-smokers (HR=0.90, 95% CI = 0.74 - 1.09) (P-interaction = 0.029). Compared with age at first delivery ≤20 years, older age at first delivery (≥26 years) was associated with a lower risk of lung cancer incidence and mortality. Compared with age at menopause <45 years, older age at menopause (≥55 years) was associated with a decreased risk of lung cancer mortality (HR=0.75, 95% CI = 0.58 - 0.96). Women who ever used hormone replacements had a higher likelihood of developing non-small cell lung cancer (HR = 1.30, 95% CI = 1.01 - 1.67), compared to those who never used hormone replacements. Conclusions: Distinct from Western women, Asian parous women, especially those who have 1-2 children had a lower risk of lung cancer incidence and mortality compared with nulliparous women. Future studies are needed to assess the underlying mechanisms, the relationships within these female reproductive factors, and the potential changes in smoking habits over time. Citation Format: Xin Yin, Rie Kishida, Sarah Krull Abe, Md. Rashedul Islam, Md. Shafiur Rahman, Eiko Saito, Qing Lan, Batel Bletcher, Melissa Merritt, Ji-Yeob Choi, Aesun Shin, Ryoko Katagiri, Xiao-Ou Shu, Norie Sawada, Akiko Tamakoshi, Woon-Puay Koh, Ichiro Tsuji, Chisato Nagata, Sue K. Park, Sun-Seog Kweon, Yu-Tang Gao, Shoichiro Tsugane, Takashi Kimura, Jian-Min Yuan, Yukai Lu, Seiki Kanemura, Yumi Sugawara, Keiko Wada, Min-Ho Shin, Habibul Ahsan, Paolo Boffetta, Kee Seng Chia, Keitaro Matsuo, You-Lin Qiao, Nathaniel Rothman, Wei Zheng, Manami Inoue, Daehee Kang, Wei Jie Seow. Association between reproductive factors with lung cancer incidence and mortality: A pooled analysis of over 308,000 females in the Asia Cohort Consortium. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 4200.
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Gerson-Gurwitz, Adina, Pengyu Yang, Sarah Fish, Gabrielle Blanco, Hongfeng Gao, Kyohei Hayashi, Mike Hocker i in. "Abstract 3309: Discovery of potent and selective bivalent CDK2 degraders that demonstrate activity in CCNE1amp driven tumors". Cancer Research 84, nr 6_Supplement (22.03.2024): 3309. http://dx.doi.org/10.1158/1538-7445.am2024-3309.
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Abstract Introduction: The Cyclin-Dependent Kinases (CDKs) with their cyclin binding partners, are associated with cell cycle progression and transcriptional regulation. Targeting CDKs is a key oncology therapeutic strategy with CDK4/6 inhibitors demonstrating significant clinical benefit in HR+/HER2− metastatic breast cancer, the most prevalent subtype. However, 30% of patients develop acquired resistance in the clinic with cyclin E1 (CCNE1) amplification/overexpression and CDK2 activation implicated as a major resistance mechanism to CDK4/6i breast cancer therapy. Additionally, CCNE1/CDK2 activation has also been associated with poor prognosis in ovarian and endometrial cancers. Selective targeting of CDK2 using small molecule inhibitor-based approaches have recently advanced into the clinic. Targeted protein degradation of CDK2 provides an alternative strategy that has the potential to eliminate the activity of the CCNE1/CDK2 complex, as well as CDK2 complexed with other cyclins, including cyclin A, and provide improved clinical benefit. Results: Discovery efforts at Plexium have identified CDK2 bivalent degraders that consist of a CDK2-binding moiety, a linker and a high affinity cereblon-binding ligand. Cereblon binding potency was found to correlate with potent and deep degradation of CDK2. Degradation was blocked in the presence of a proteasome inhibitor as well as in a cereblon knock-out cell line, confirming that CDK2 degradation is mediated by the ubiquitin proteasome system and through engaging cereblon. Proteome-wide analysis demonstrated that CDK2 was selectively depleted without significantly modulating other CDKs or known cereblon neo-substrates. Selective degradation was achieved despite lack of selectivity for binding/inhibition of other CDKs and was confirmed to be dependent on the formation of a CRBN-CDK2 ternary complex. Dose dependent CDK2 degradation resulted in dose dependent inhibition of Rb phosphorylation, cell cycle arrest, senescence-associated phenotypes and antiproliferative activity in CCNE1 amplified cancer cell lines. The in vitro data was used to evaluate the PK/PD drug exposure-response relationship in vivo and deep CDK2 degradation was demonstrated both in vitro and in vivo. Conclusions: These data provide validation for CDK2 degradation as a therapeutic approach. Potent and selective CDK2 bivalent degraders were exploited as tools for studying the sensitivity of CCNE1 amplified tumor models to CDK2 degradation and dependence on E3 ligase. This proof-of concept study supports Plexium’s current approach of discovering novel CDK2 molecular glue degraders for the treatment of CDK4/6 inhibitor-naïve and -resistant HR+/HER2− breast cancer, and CCNE1 amplified ovarian and endometrial cancers. Citation Format: Adina Gerson-Gurwitz, Pengyu Yang, Sarah Fish, Gabrielle Blanco, Hongfeng Gao, Kyohei Hayashi, Mike Hocker, Aleks Jamborcic, Andre Richters, Mary E. Spalding, Julia Toth, Duc Tran, Linette Yang, Shu You, Andrew Burritt, Alex Campos, Gregory Parker, Kevin Freeman-Cook, Peggy A. Thompson, Simon Bailey. Discovery of potent and selective bivalent CDK2 degraders that demonstrate activity in CCNE1amp driven tumors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 3309.
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JEONG, Sangbong. "Cheng-Zhu’s Theory of Zhongshu and Contemporary Confucians’ Interpretation". Tae Dong Institute of classic research 50 (30.06.2023): 43–70. http://dx.doi.org/10.31408/tdicr.2023.50.43.
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Cheng brothers and Zhu Xi explained Zhongshu忠恕 by dividing it into the Zhongshu of saints and the Zhongshu of scholars. If the Zhongshu of a saint completely realizes the Zhongshu of heaven and earth without any selfishness, the Zhongshu of a scholar requires constant efforts to practice. In particular, Zhu Xi paid attention to the Zhongshu of scholars, set up a problem situation in which Zhongshu was not carried out properly, and then suggested the study of deliberation and sincerity as a solution. According to Cheng-Zhu’s theory of Zhongshu, Zhong and Shu have a logical structure of Ti體 and Yong用. The relationship between the two can be seen as the relationship between Ili一理 and Wanshu萬殊. Feng Youlan, Tang Junyi, Xu Fuguan, and Mou Zongsan, who are counted as the contemporary Confucians, each presented different interpretations of Cheng-Zhu’s theory of Zhongshu from their own perspectives. Feng Youlan refers to “Desiring to take his stand, one who is Good helps others to take their stand; wanting to realize himself, he helps others to realize themselves.” as Zhong忠, “Do not impose upon others what you yourself do not desire.” as Shu恕. On the other hand, Tang Junyi considers the former as active Shu and the latter as passive Shu. In addition, Xu Fuguan divided Zhong and Shu into two aspects: the completion of one’s own self(成己) and the completion of all things(成物). Lastly, Mou Zongsan insists that Cheng Mingdao’s understanding which explained Zhongshu in the dimension where the heavenly principle is constantly revealed, that is, “existing and active”, is correct. In addition, he evaluates that the explanations of Cheng Yichuan and Zhu Xi did not properly explain the true meaning of Zhongshu. The various explanations of the contemporary Confucians on Zhongshu each have their own grounds for argument. It can be said that their various reading methods have broadened the horizon of interpretation. Korean scholars generally take the view of Tang Junyi’s view, which divides Shu into positive and negative aspects among Contemporary Confucians’ Interpretations. I think this is because it keeps in mind Cheng-Zhu’s theory of Zhongshu. In the future, in-depth discussions on the modern significance of Zhongshu should be added.
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Zhang, Qianpeng, Daquan Zhang, Xiaofei Sun, Beitao Ren i Zhiyong Fan. "(Invited, Digital Presentation) High-Efficiency and Stable Perovskite LEDs and Displays with Nanophotonic Methods". ECS Meeting Abstracts MA2022-02, nr 36 (9.10.2022): 1308. http://dx.doi.org/10.1149/ma2022-02361308mtgabs.
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Perovskite light-emitting diodes (PeLEDs) have experienced rapid development in the past 8 years. The external quantum efficiencies (EQEs) of red, green, and near-infrared (NIR) PeLEDs have all surpassed the 20% milestone. Meanwhile, the blue PeLEDs also achieved EQEs higher than 10% and are catching up quickly with PeLEDs of other colors. However, there are still two key problems remaining within the PeLEDs for their further development, namely the light extraction problem and the short lifetime problem. Therefore, in this report, we will discuss our recent work targeting addressing the above two critical problems. First, our work on improving the light extraction efficiency by deploying the nanophotonic substrates will be introduced. Second, the improvement of the device’s operational lifetime at high luminance conditions with perovskite nanowires embedded in a porous alumina template will be discussed. Third, a full evaporation method that is compatible with industrialization will be shown. Last but not least, our endeavors on the displays based on perovskite materials will be covered. References [1] Q. Zhang, M. M. Tavakoli, L. Gu, D. Zhang, L. Tang, Y. Gao, J. Guo, Y. Lin, S. -F. Leung, S. Poddar, Y. Fu, Z. Fan, "Efficient metal halide perovskite light-emitting diodes with significantly improved light extraction on nanophotonic substrates," Nature Communications, 10 (1), 727 (2019). [2] Q. Zhang, D. Zhang, L. Gu, S. Poddar, Y. Fu, L. Shu, and Z. Fan, “Three-dimensional perovskite nanophotonic wire array-based light-emitting diodes with significantly improved efficiency and stability,” ACS Nano, 14 (2), 1577-1585 (2020). [3] Y. Fu, Q. Zhang, D. Zhang, Y. Tang, L. Shu, Y. Zhu, and Z. Fan, “Scalable All-evaporation Fabrication of Efficient Light-Emitting Diodes with Hybrid 2D-3D Perovskite Nanostructures,” Advanced Functional Materials, 30, 2002913 (2020). [4] D. Zhang, Q. Zhang, B. Ren, Y. Zhu, M. Abdellah, Y. Fu, B. Cao, C. Wang, L. Gu, Y. Ding, K.-H. Tsui, S. Fan, S. Poddar, L. Shu, Y. Zhang, D.-B. Kuang, J.-F. Liao, Y. Lu, K. Zheng, Z. He, Z. Fan, “Large-scale Planar and Spherical Light-emitting Diodes Based on Arrays of Perovskite Quantum Wires”, Nature Photonics, 19, 284-290 (2022).
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Cheang, Shu Lea, i Alexandra Juhasz. "When Are You Going to Catch Up with Me?" Camera Obscura: Feminism, Culture, and Media Studies 35, nr 3 (1.12.2020): 116–31. http://dx.doi.org/10.1215/02705346-8631583.
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“Digital nomad” Shu Lea Cheang and friend and critic Alexandra Juhasz consider the reasons for and implications of the censorship of Cheang’s 2017 film FLUIDØ, particularly as it connects to their shared concerns in AIDS activism, feminism, pornography, and queer media. They consider changing norms, politics, and film practices in relation to technology and the body. They debate how we might know, and what we might need, from feminist-queer pornography given feminist-queer engagements with our bodies and ever more common cyborgian existences. Their informal chat opens a window onto the interconnections and adaptations that live between friends, sex, technology, illness, feminism, and representation.
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Chao, Xue-lin, Shu-zhen Jiang, Jian-wen Xiong, Jin-qiong Zhan, Bo Wei, Chun-nuan Chen i Yuan-jian Yang. "Erratum to: Changes of Serum Insulin-like Growth Factor-2 Response to Negative Symptom Improvements in Schizophrenia Patients Treated with Atypical Antipsychotics". Current Medical Science 40, nr 5 (październik 2020): 997. http://dx.doi.org/10.1007/s11596-020-2256-3.
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The article “Changes of Serum Insulin-like Growth Factor-2 Response to Negative Symptom Improvements in Schizophrenia Patients Treated with Atypical Antipsychotics”, written by Xue-lin CHAO, Shu-zhen JIANG, Jian-wen XIONG, Jin-qiong ZHAN, Bo WEI, Chun-nuan CHEN, Yuan-jian YANG was originally published electronically on the publisher’s internet portal on June 2020 without open access. With the author(s)’ decision to opt for Open Choice, the copyright of the article is changed to © The Author(s) 2020 and the article is forthwith distributed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
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Shortliffe, L. A. "The Bridle". After Dinner Conversation 2, nr 10 (2021): 40–49. http://dx.doi.org/10.5840/adc202121093.
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Should you ask honest questions even if asking those questions will cause you to be the object of public cruelty and ostracization? In this work of philosophical short story fiction, the narrator is serving a six-month punishment of “condemning.” During her punishment she must wear a gag in her mouth, and a cage over her face, whenever she leaves her house. Furthermore, all those seeing her will know her, loath her, and ridicule her. Showing the least kindness to her could put the person showing the kindness at risk. Because of her condemning, the narrator has lost her job and is forced to dig through trash cans for rotting food to eat. She has also had her children taken away from her. While we do not know what she did to deserve this punishment, it seems to have involved asking public questions, or making public statements, that were criminal within the society.
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Hancock, Jennifer, Simon Huang i Samara Zavalkoff. "Just the facts: Organ donation in the emergency department: When you can't save one, save eight". CJEM 22, nr 2 (marzec 2020): 155–58. http://dx.doi.org/10.1017/cem.2019.456.
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A 16-year-old female presents to a community emergency room following a suicide attempt by hanging. Prehospital, on arrival of paramedics, the patient was in a pulseless electrical activity rhythm. Paramedics provided advanced cardiac life support for 20 minutes before they obtained return of spontaneous circulation. In the emergency department, she had another 25-minute cardiac arrest with ultimate return of spontaneous circulation. She is now hemodynamically stable on Levophed 0.2 µg/kg/min. Her neurological exam shows pupils to be 3 mm and fixed bilaterally, absent cough and gag, and no response to central or peripheral pain. She occasionally triggers 2–3 spontaneous breaths per minute above the set rate on the ventilator. Her CT head scan shows severe anoxic changes and cerebral edema.
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Jewett, Paul K. "Children of Grace". Theology Today 44, nr 2 (lipiec 1987): 170–78. http://dx.doi.org/10.1177/004057368704400204.
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“Tell me, you who desire to be under the law, do you not hear the law? For it is written that Abraham had two sons, one by a slave and one by a free woman. But the son of the slave was born according to the flesh, the son of the free woman through promise. Such things are allegorical utterances: for these women are two covenants. One is from Mount Sinai bearing children for slavery; she is Hagar. Now Hagar is Mount Sinai in Arabia; she corresponds to the present Jerusalem, for she is in slavery with her children. But the Jerusalem above is free, and she is our mother. … Now we, brothers and sisters, like Isaac, are children of promise. But as at that time he who was born according to the flesh persecuted him who was born according to the Spirit, so it is now. But what does the Scripture say? ‘Cast out the slave and her son for the slave shall not inherit with the son of the free woman.’ So, brothers and sisters, we are not children of the slave but of the free woman” (Gal. 4:21–31; see also, Gen. 16:1–6; 21:1–7).
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Long, Haiping, i Pengfei Kuang. "Modern Chinese confirmative shi". Functions of Language 24, nr 3 (31.12.2017): 294–318. http://dx.doi.org/10.1075/fol.15018.lon.
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Abstract Modern Chinese confirmative shi (as in mei cuo, wo shi yao dusi ni (沒錯，我是要毒死你) ‘that’s right. I really wanted to poison you to death’) is not an auxiliary but an adverb. It derives from the adjective shi ‘true, real’ in Old Chinese (Yan zhi yan shi ye (偃之言是也) ‘what Yan said was true’). The grammaticalization pathway of the Modern Chinese confirmative shi is different from that of the copula shi (Laozhang shi huoche siji (老張是貨車司機) ‘Laozhang is a truck driver’) or the auxiliary shi (Laozhang shi kai huoche, wo shi kai keche (老張是開貨車，我是開客車) ‘Laozhang drives a truck and I drive a coach car’). Modern Chinese confirmative shi, copula shi, and auxiliary shi have the same morphological form because they all appear to derive from the adjective shi or demonstrative ( shi ke ren, shu bu ke ren ( 是可忍，孰不可忍) ‘if this could be endured, is there anything else that could not be endured’) in Old Chinese. Such a pattern of morphological sameness seems to be cross-linguistically rare, if not unique.
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Lewis, John W., i Xue Litai. "Li Chengzhi. A Draft History of Space Technology in China [Zhongguo hangtian jishu fazhan shi gao]. (Zhongguo jin xian dai ke xue ji shu shi yan jiu cong shu.) 3 volumes. 939 pp., illus., tables, bibl., index. Jinan: Shandong Education Press [Shandong jiao yu chu ban she], 2006. ¥106 (paper)." Isis 101, nr 3 (wrzesień 2010): 677–78. http://dx.doi.org/10.1086/657225.
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Fan, Fa-ti. "Zonggang Hu. Jingsheng sheng wu diao cha suo shi gao [Historical manuscript of Fan Memorial Institute of Biology]. (Zhongguo jin xian dai ke xue ji shu shi yan jiu cong shu.). 250 pp., illus., figs., tables, bibl., index. Jinan: Shangdong jiao yu chu ban she [Shandong Education Press], 2005. 29 yuan (paper)." Isis 99, nr 1 (marzec 2008): 214. http://dx.doi.org/10.1086/589390.
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Fetzer, Stefan, i Stefan Moog. "Indicators for Measuring Intergenerational Fairness of Social Security Systems—The Case of the German Social Health Insurance". Sustainability 13, nr 10 (20.05.2021): 5743. http://dx.doi.org/10.3390/su13105743.
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The issue of fiscal sustainability is often labelled as a synonym for intergenerational fairness; however, pay-as-you-go schemes such as the German Social Health Insurance (SHI) involve a “natural” amount of intergenerational redistribution from younger net payers to older net beneficiaries. We calculate intertemporal balance sheets of SHI and compare two generational accounting approaches (GAC and GAIB) with an alternative measure of intergenerational fairness, SM, which we derive from Settergren and Mikula (2005). Our results indicate that the SM concept leads to similar implications concerning the amount of intergenerational redistribution as classical measures of fiscal sustainability. For the SM approach, the balance sheet of SHI shows a rate of unfunded benefits of 25 percent. Closing this gap requires an increase of the contribution rate by 30 to 40 percent. This total effect can be separated into an effect due to the current population structure (10 p.p.), the increase in life expectancy (10 p.p.), and medical technical progress (about 10 to 20 p.p.).
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Chen, Xiang. "Zengjian Guan et alia. Zhongguo jin xian dai ji liang shi gao [A Draft of the History of Modern and Contemporary Metrology in China]. (Zhongguo jin xian dai ke xue ji shu shi yan jiu cong shu.) 258 pp., tables, bibl., index. Jinan: Shandong jiao yu chu ban she [Shandong Education Press], 2005. ¥30.50 (paper)." Isis 100, nr 2 (czerwiec 2009): 389–90. http://dx.doi.org/10.1086/605226.
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Fang, Li-Zhi. "Jiang Xiaoyuan ;, Wu Yan . Zijin shan tian wen tai shi gao: Zhongguo tian wen xue xian dai hua ge an. [History of Purplemountain Observatory.] (Zhongguo jin xian dai ke xue ji shu shi yan jiu cong shu.). 219 pp., tables, bibl., index. Jinan: Shandong jiao yu chu ban she [Shandong Education Press], 2004. 29 (paper)." Isis 99, nr 3 (wrzesień 2008): 645–46. http://dx.doi.org/10.1086/593267.
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Welch, Rosanne. "Honey, You Know I Can’t Hear You When You Aren’t in the Room". Networking Knowledge: Journal of the MeCCSA Postgraduate Network 10, nr 2 (14.06.2017): 69–78. http://dx.doi.org/10.31165/nk.2017.102.509.
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The need for more diversity in Hollywood films and television is currently being debated by scholars and content makers alike, but where is the proof that more diverse writers will create more diverse material? Since all forms of art are subjective, there is no perfect way to prove the importance of having female writers in the room except through samples of qualitative case studies of various female writers across the history of film. By studying the writing of several female screenwriters – personal correspondence, interviews and their writing for the screen – this paper will begin to prove that having a female voice in the room has made a difference in several prominent films. It will further hypothesise that greater representation can only create greater opportunity for more female stories and voices to be heard.
Research for my PhD dissertation ‘Married: With Screenplay’ involved the work of several prominent female screenwriters across the first century of filmmaking, including Anita Loos, Dorothy Parker, Frances Goodrich and Joan Didion. In all of their memoirs and other writings about working on screenplays, each mentioned the importance of (often) being the lone woman in the room during pitches and during the development of a screenplay. Goodrich summarised all their experiences concisely when she wrote, ‘I’m always the only woman working on the picture and I hold the fate of the women [characters] in my hand… I’ll fight for what the gal will or will not do, and I can be completely unfeminine about it.’ Also, the rise of female directors, such as Barbra Streisand or female production executives, such as Kathleen Kennedy, prove that one of the greatest assets to having a female voice in the room is the ability to invite other women inside. Therefore, this paper contributes to the scholarship on women in film and to authorship studies.
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Yang, Jingjing, Qing Zhang, Hao Zhang, Yi Xiang, Tingshuai Fu i Jiajia Ding. "Network Meta-analysis of Oral Chinese Patent Medicine in Treatment of Primary Osteoporosis". Journal of Physics: Conference Series 2400, nr 1 (1.12.2022): 012024. http://dx.doi.org/10.1088/1742-6596/2400/1/012024.
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Abstract The efficacy of oral proprietary Chinese medicine in the prevention and treatment of primary osteoporosis was systematically evaluated through a network meta-analysis. The computer retrieved the four major Chinese databases of CNKI, VIP, Wang Fang, CBM in China and abroad, as well as the three English databases and Web of Science of Medline, EMbase and Cochrane Library. The search cycle was designed as the database was established until February 15, 2022, and screened randomized controlled trials of export taking proprietary Chinese medicine combined with conventional western medicine for the prevention and treatment of primary osteoporosis according to the system evaluation pre-formulated exclusion criteria. Literature screening and data extraction are completed by at least 2 clinical investigators alone. Bias assessment and mapping of included studies using the Revman software, using the Cochrane Bias Risk Assessment tool, using Stata 16. 0 Software for data acquisition and analysis. In the end, 19 RCTS were included, involving 8 kinds of oral proprietary Chinese medicines (You Gui Pills, Jin Tiange Capsules, Gu Shu Kang Granules, Qiang Bone Capsules, Gu Songbao Granules, Xianling Gu Bao Capsules, Hu Gu Capsules, Zuo Gui Pills). The results of the network meta-study are as follows: (1) in terms of improving clinical efficiency, conventional western medicine combined with Hu Gu Capsules has the best effect; (2) in terms of improving bone density, conventional western medicine combined with Xianling Gu Bao has the best effect. This network meta-analysis provides evidence for the efficacy of the above eight proprietary Chinese medicines in the treatment of patients with POP.
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Tang, Yan, i Zhiping Yu. "Towards Others: Confucian Shu’s (Due Consideration) Three Types of Gongfu (Practice)". Religions 14, nr 7 (23.06.2023): 824. http://dx.doi.org/10.3390/rel14070824.
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The Confucian philosophy of the Dao of due consideration 恕 (shu) and of “Do not impose upon others what you yourself do not desire ” 己所不欲，勿施於人 undoubtedly involves the question of “others” and addresses the spiritual pursuit of individual equality, mutual agreement, and communality. Confucianism’s theory of practice 工夫 (gongfu), while emphasizing the establishment and success of oneself, also requires the ability to make others established and successful. There are basically three paths for the virtuous subject to reach others: “taking what is near at hand as an analogy ” 能近取譬 (neng jin qu pi), the “measure” 度 (duo) of considering other people’s emotions on the basis of one’s own emotions 將心比心 (jiang xin bi xin), and putting oneself in the place of others 推己及人 (tui ji ji ren). The present study, drawing on the long commentarial tradition, will fully explicate them as gongfu, that is, as concrete processes of moral practice, revealing the three paths of the Dao of due consideration from self to others, and interpreting them in relation to the dimension of the other in Confucian ethical philosophy. All three are unified and highly practical and are effective means of realizing Confucian benevolence 仁 (ren). They do not exist in a sequential ascending relationship. Through diligent moral practice, people can “help others to take their stand” 立人 (liren) and “help others to realize themselves” 達人 (daren) by following any one of the three types of gongfu.
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M., Isa,, i Nuhu, H. "Kasuwar Birnin Zariya Jiya Da Yau". Tasambo Journal of Language, Literature, and Culture 1, nr 1 (20.12.2022): 180–84. http://dx.doi.org/10.36349/tjllc.2022.v01i01.019.
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Wannan nazari ya gudana ne don ya binciko irin tasiri da matsayin da wannan kasuwa ke da shi a ƙasar Zazzau, tun daga dauri zuwa yanzu. Tattaunawa da ziyarar gani da ido tare da nazari, su ne manyan hanyoyin da aka yi amfani da su wajen tattaro bayanan da aka gina aikin da su. An yi ƙoƙarin bibiyan tarihi da bunƙasar wannan kasuwa tun kafuwarta zuwa yau. Nazarin ya yi nasarar gano cewa kasuwar ta fi bayar da ƙarfi a ɓangaren ɗinki ne da kuma sayar da yadudduka. Sauran hajoji, ba safai ake samunsu ba a kasuwar sai dai nadiran. A ƙarshe, nazarin ya bayyana buƙatar faɗaɗa ko sabunta matsugunin wannan kasuwa da ake da ita, domin ta ƙanƙance ta zamo tamkar unguwa.
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Chen, Bo, Pengfei Xu, Joy C. Yang, Shu Ning, Leyi Wang, Christopher Nip, Allen C. Gao i Chengfei Liu. "Abstract 3577: The role of PLXND1 in lineage plasticity and progression to neuroendocrine prostate cancer". Cancer Research 84, nr 6_Supplement (22.03.2024): 3577. http://dx.doi.org/10.1158/1538-7445.am2024-3577.
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Abstract Background: Neuroendocrine prostate cancer (NEPC) is a lethal subtype of prostate cancer and is commonly associated with therapy resistance and poor prognosis. Treatment-induced NEPC (t-NEPC) predominantly develops by lineage plasticity from adenocarcinoma in response to androgen receptor signaling inhibitors, such as enzalutamide. However, the mechanisms underlying the lineage plasticity and progression to NEPC are unclear. PLXND1 (PlexinD1) is a cellular receptor of the semaphorin family and has important functions in modulating the cytoskeleton and cell adhesion. However, the role of PLXND1 in lineage plasticity to NEPC development and progression is not well established. Methods: We performed transcriptomic analysis on NEPC patients’ cohorts and the enzalutamide-resistant prostate cancer cell lines. Correlation of PLXND1 with neuroendocrine feature genes and AR-targeting genes was determined. Kaplan-Meier method and the Cox proportional hazards model was used to estimate the correlation between PLXND1 expression level and patients’ survival. Immunohistochemistry was used to analyze PLXND1 expression in prostate adenocarcinoma and NEPC. Cell viability was determined in C4-2B MDVR, CWR22Rv1, and H660 cells after knocking down PLXND1 using siRNA or knocking out PLXND1 using CRISPR/CAS9. Organoids viability of patient-derived xenografts was measured after knocking down or knocking out PLXND1. Results: Our analysis on different patient cohorts suggests that PLXND1 is highly expressed in NEPC patients, and the expression of PLXND1 is positively correlated with neuroendocrine feature genes (CHGA, ENO2, SYP, and NCAM1). Kaplan-Meier survival analysis shows that high expression of PLXND1 is significantly associated with the poor prognosis of prostate cancer patients. PLXND1 is overexpressed and negatively regulated by androgen receptor signaling in enzalutamide-resistant cells and prostate cancer patients’ cohorts. Furthermore, downregulation of PLXND1 expression suppressed proliferation of the NEPC cells and viability of the PDX tumor organoids. Conclusions: PLXND1 expression is elevated in NEPC and correlated with the poor survival of prostate cancer patients, suggesting it is a potential molecular indicator and therapy target for NEPC. Citation Format: Bo Chen, Pengfei Xu, Joy C. Yang, Shu Ning, Leyi Wang, Christopher Nip, Allen C. Gao, Chengfei Liu. The role of PLXND1 in lineage plasticity and progression to neuroendocrine prostate cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 3577.
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Mun, Jeong-Yeon, Chang Shu, Qiuqiang Gao, Mike-Andrew Westhoff, Georg Karpel-Massler i Markus D. Siegelin. "Abstract 3070: CDK12 is a novel therapeutic target in glioblastoma". Cancer Research 84, nr 6_Supplement (22.03.2024): 3070. http://dx.doi.org/10.1158/1538-7445.am2024-3070.
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Abstract Glioblastoma (GBM), the most common primary brain tumor in adults carries a highly unfavorable prognosis of only one to two years despite treatment with the standard of care, involving surgery, temozolomide and radiation. Patient-derived xenograft (PDX) GBM cultures were assessed for their susceptibility to loss of CDK12 function, which was either mediated genetically (shRNA) or by the novel inhibitor, SR-4835. GBM metabolism was measured by utilizing extracellular flux analysis as well as LC/MS based carbon tracing analyses. In vivo efficacy was determined by orthotopic GBM models in mice. Based on Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) and shRNA library screens in multiple GBM cell cultures we identified CDK12 as essential for the growth of GBM. Consistently, loss of function of CDK12 (genetically and pharmacologically) led to a reduction of growth of GBM patient-derived xenograft (PDX) lines in vitro. Notably, SR-4835 reduced GBM growth in the low nanomolar range and synergistically enhanced the potency of temozolomide. Extracellular flux analysis and metabolite screening analyses, including carbon tracing (U13C-Glucose, U13C-Glutamine) suggested that loss of function of CDK12 elicited a substantial inhibition of cellular respiration, causing energy deprivation with subsequent cell death with apoptotic features. On the molecular level, loss of function of CDK12 increased ATF4 along with pro-apoptotic Noxa, whereas anti-apoptotic Mcl-1 decreased. In turn, adenoviral mediated ectopic expression of Mcl-1 inhibited cell death mediated by loss of function of CDK12 in GBM cells. In an orthotopic murine PDX model of GBM animals receiving treatment with SR-4835 had a significantly longer overall survival without induction of toxicity as compared to mice treated with vehicle. In summary, these findings suggest that CDK12 is a novel treatment target for GBM and that CDK12 is an important driver of energy metabolism in GBM to partially mediate apoptotic resistance. Moreover, SR-4835 enhanced the potency of temozolomide in GBM models. Therefore, the novel CDK12 inhibitor, SR-4835 should be tested in a clinical trial in patients suffering from GBM. Citation Format: Jeong-Yeon Mun, Chang Shu, Qiuqiang Gao, Mike-Andrew Westhoff, Georg Karpel-Massler, Markus D. Siegelin. CDK12 is a novel therapeutic target in glioblastoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 3070.
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Zhu, Yuelin. "Li Zhang. Xin Zhongguo yu xin ke xue: gao fen zi xue zai xian dai Zhongguo de jian li [New Science for a New China: Institutionalization of Polymer Science in the P. R. China]. (Zhongguo jin xian dai ke xue ji shu shi yan jiu cong shu.). 340 pp., tables, bibl., index. Jinan: Shandong jiao yu chu ban she [Shandong Education Press], 2005. ¥37.50 (paper)." Isis 99, nr 2 (czerwiec 2008): 446–47. http://dx.doi.org/10.1086/591385.
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Kim, Sangdeog Augustin. "Are they Similar or are they Same Origin, Persian Language and Korean Language? (0153-0163)". South Asian Research Journal of Humanities and Social Sciences 5, nr 07 (4.07.2023): 116–17. http://dx.doi.org/10.36346/sarjhss.2023.v05i04.003.
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French missionary Dallet (1874) wrote in his book that Korean language is different from Chinese language. Several researchers studied the relation between Persian words and Korean words (Park et al., 2019: Kim and Park, 2022). The present researcher tried to find out the relation between Persian language and Korean language. The researcher selected several Persian words, and imagined possible counter-part Korean words. The present researcher used a Dictionary of Persian/French and French/Persian (Bau, 2008). This study was done on the basis of pronunciation of the two languages. The title is ‘Are they similar or are they same origin, Persian language and Korean language? (0153-0163)’. The result obtained is as follows. <number Persian word (its meaning) Korean word (its meaning in English)> 0152-2 Neza (dispute) Eo-zzu (It is not good! It is not right!) 0153-1 Mizan (balance) Mis-zin (He or she lost the money, There is not any gain.) 0153-2 Mizan (balance) Mas-tchun (adjusted) 0154 Maqad (anus) Mag-a (You, close the anus!) 0155 Ba kar (necessary) Ba-ggweo (You, change the thing!) 0156 Qadim (antique) Gga- dang (the voice of knock down, the voice of falling) 0157 Zadan (strike, batter) Tchada (kick) 0158 Mehmiz zadan (claw, talon) Maen-mis Tchada (strike the lowest part) 0159 Mehmiz (claw of iron) Mae maz-zi? (You, you get flogged, you are whipped, you are hit?) 0160 Maydan (soil, plain) Maen ddang (bare ground, ground) 0161-1 Mahram (lunar calendar) Ma-gam (It was closed! It was ended.) 0161-2 Mahram (lunar calendar) Mal-eum (the rolled thing) 0161-3 Mahram (lunar calendar) Mul-leo-nam (retreat) 0161-4 Mahram (lunar calendar) Mus-na-eum (All of them are cured.) 0162 Adawat (not favorable) A! Ddeu-geo-weo! (It is too hot! I do not like the thing!) 0163 Al yawm (today) An-nyeong ha-se-yo! (How are you, today?).
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Yang, Joy C., Shu Ning, Hans Adomat, Martin Gleave, Allen Gao, Christopher P. Evans i Chengfei Liu. "Abstract 3099: Biological evaluation of a novel AKR1C3 inhibitor in patient-derived prostate cancer cell line and xenograft models". Cancer Research 82, nr 12_Supplement (15.06.2022): 3099. http://dx.doi.org/10.1158/1538-7445.am2022-3099.
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Abstract INTRODUCTION AND OBJECTIVES: Prostate cancer is a highly heterogeneous cancer type with distinct genomic and phenotypic characteristics that drive tumorigenesis and the differential response to drug therapies. A limit number of prostate cancer cell lines and patient-derived xenograft (PDX) models hinders research to improve disease outcome. Some currently available PDX models were derived from the primary tumor samples are insufficient to recapitulate the clinical response at more advanced stages. In this study, we developed patient-derived models from patients with advanced disease and evaluated a novel AKR1C3 inhibitor in these models. METHODS: Samples received from our Pathology Biorepository Shared Resource were divided into four groups and subjected to pathological staining, RNA extraction, xenografting in NSG mice via renal capsule and subcutaneous implantation in SCID mice and conditional reprogramed cultures (CRCs) or organoid culturing. The AKR1C3 inhibitor PB was modified from celecoxib. Androgen receptor (AR), AR-V7 and AKR1C3 expression were determined by western blot. The effects of the AKR1C3 inhibitor on enzalutamide sensitivity were characterized by growth assay and colony formation assay. RESULTS: Eight PDX models have been developed from prostate cancer patients with high Gleason score and/or at the castration-resistant stages. Among the PDX models, one spontaneous indefinite cell line PS1172 was established. Early passage CRCs showed the epithelial morphology with AR positive expression. Through serially passaging PS1172 PDX with castration in SCID mice, the castration resistant cell line 1172CR was re-cultured from castration-resistant PS1172 PDX tumors. 1172CR cells were resistant to enzalutamide treatment and expressed high level of AKR1C3 and AR-V7. A novel AKR1C3 inhibitor (PB) which displayed superior potential to inhibit AKR1C3 activity and suppress enzalutamide resistant prostate cancer cell growth was tested in these models. At the same dose, PB significantly suppressed 1172CR cell growth and colony formation compared to indomethacin and enzalutamide. PB also significantly suppressed AR/AR-V7 protein expression compared to indomethacin in 1172CR cells. CONCLUSION: PS1172 and castration-resistant 1172CR cells are novel models with significant characteristics such as AR-V7 and AKR1C3. These novel prostate cancer models are ideal for small molecule testing and resistant mechanism investigating. Citation Format: Joy C. Yang, Shu Ning, Hans Adomat, Martin Gleave, Allen Gao, Christopher P. Evans, Chengfei Liu. Biological evaluation of a novel AKR1C3 inhibitor in patient-derived prostate cancer cell line and xenograft models [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 3099.
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Rahman, Mohammad L., Xiao-Ou Shu, Douglas Walker, Dean P. Jones, Wei Hu, Bu-tian Ji, Batel Blechter i in. "Abstract 6056: A nested case-control study of untargeted plasma metabolomics and lung cancer risk among never-smoking women in the prospective Shanghai Women’s Health Study". Cancer Research 83, nr 7_Supplement (4.04.2023): 6056. http://dx.doi.org/10.1158/1538-7445.am2023-6056.
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Abstract Background: The etiology of lung cancer among never-smokers is unclear despite 15% of cases in men and 53% in women worldwide are not smoking-related. Metabolomics provides a snapshot of dynamic biochemical activities, including those found to be driving tumor formation and progression. This study used untargeted metabolomics with network analysis to agnostically identify network modules and independent metabolites in pre-diagnostic blood samples among never-smokers to further understand the pathogenesis of lung cancer. Methods: Within the prospective Shanghai Women’s Health Study, we conducted a nested case-control study of 395 never-smoking incident lung cancer cases and 395 never-smoking controls matched on age. We performed liquid chromatography high-resolution mass spectrometry to quantify 20,348 unique metabolic features in plasma. Because metabolic features are expected to be highly correlated and more likely to be involved in biological processes as a network of intertwined features than individually, we agnostically constructed 28 network modules using a weighted correlation network analysis approach. The associations between metabolite network modules and individual metabolites with lung cancer were assessed using conditional logistic regression models, adjusting for age, body mass index, and exposure to environmental tobacco smoke. We accounted for multiple testing using a false discovery rate (FDR) < 0.20. Results: We identified a network module of 122 metabolic features enriched in lysophosphatidylethanolamines that was associated with all lung cancer combined (p = 0.001, FDR = 0.028) and lung adenocarcinoma (p = 0.002, FDR = 0.056) and another network module of 440 metabolic features that was associated with lung adenocarcinoma (p = 0.014, FDR = 0.196). Metabolic features were enriched in pathways associated with cell growth and proliferation, including oxidative stress, bile acid biosynthesis, and metabolism of nucleic acids, carbohydrates, and amino acids, including 1-carbon compounds. Conclusions: Our prospective study suggests that untargeted plasma metabolomics in pre-diagnostic samples could provide new insights into the etiology of lung cancer in never-smokers. Replication and further characterization of these associations are warranted. Citation Format: Mohammad L. Rahman, Xiao-Ou Shu, Douglas Walker, Dean P. Jones, Wei Hu, Bu-tian Ji, Batel Blechter, Jason YY Wong, Qiuyin Cai, Gong Yang, Tu-Tang Gao, Wei Zheng, Nathaniel Rothman, Qing Lan. A nested case-control study of untargeted plasma metabolomics and lung cancer risk among never-smoking women in the prospective Shanghai Women’s Health Study [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 6056.
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Xu, Pengfei, Joy C. Yang, Bo Chen, Shu Ning, Leyi Wang, Christopher Nip, Christopher P. Evans i in. "Abstract 4567: Dual targeting of HSP70 and AURKA improves treatment in neuroendocrine prostate cancer". Cancer Research 84, nr 6_Supplement (22.03.2024): 4567. http://dx.doi.org/10.1158/1538-7445.am2024-4567.
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Abstract Background: Neuroendocrine prostate cancer (NEPC) is the most aggressive type of prostate cancer with no effective treatments. Therefore, there is an urgent need to develop new treatment strategies. N-Myc plays a key role in driving NEPC progression, and Aurora kinase A (AURKA) prevents N-Myc degradation by interact with N-Myc and disallowing the intervention of ubiquitin ligases. The AURKA inhibitor Alisertib inhibits NEPC tumor growth by disrupting N-Myc signaling, but it is failed in a phase II clinical trial. In this study, we tested the synergy of novel HSP70 allosteric inhibitor JG231 and Alisertib in NEPC cells, organoids, and patient derived xenograft (PDX) models, which will provide new therapeutic strategies for the NEPC treatment. Methods: RT-PCR, western blotting, or immunohistochemistry (IHC) were used to determine the expression of N-Myc, neuroendocrine maker (NSE, SYP, CHGA, etc) in different prostate cancer cell lines and PDX tumors. After the knockdown of HSP70 and AURKA by siRNA transfection, cell proliferation and N-Myc expression were assessed by using cell viability assay, RT-PCR and Western blotting respectively. The co-immunoprecipitation assay was performed to detect the N-Myc ubiquitination. RNA-sequencing, gene set enrichment analysis was employed to determine the changes of JG231 on gene programs. The effects of JG231 and Alisertib on the proliferation were examined in NEPC cell lines and PDX organoids models. Results: We determined that PC3, CWR22Rv1, H660 cell lines, LuCaP49, and LuCaP93 PDX tumors had significantly increased the expression of N-Myc and neuroendocrine makers. Knockdown of HSP70 or using the HSP70 inhibitor, JG231, significantly inhibit the growth of H660 and CWR22Rv1 cells and leads to a synergistic effect with Alisertib (p<0.001). JG231 combined with Alisertib also inhibits growth and induces the death of LuCaP93 and H660 tumor derived organoids in a dose-dependent manner (p<0.001). Mechanistically, JG231 inhibits the protein expression of N-Myc through the ubiquitin-proteasome system and promote STUB1 to enter the nucleus to bind to N-Myc. Conclusions: JG231, a novel HSP70 inhibitor, can improves the treatment efficacy of AURKA inhibitor Alisertib against NEPC through the regulation of N-Myc protein homeostasis. Citation Format: Pengfei Xu, Joy C. Yang, Bo Chen, Shu Ning, Leyi Wang, Christopher Nip, Christopher P. Evans, Marc A. Dall'Era, Allen C. Gao, Jason Gestwicki, Chengfei Liu. Dual targeting of HSP70 and AURKA improves treatment in neuroendocrine prostate cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 4567.
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Kim, Sangdeog Augustin. "Are they similar or are they same origin, Persian language and Korean language? (0132-0144)". South Asian Research Journal of Humanities and Social Sciences 5, nr 04 (4.07.2023): 112–13. http://dx.doi.org/10.36346/sarjhss.2023.v05i04.001.
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French missionary Dallet (1874) wrote in his book that Korean language and Chinse language is really different. Several researchers studied the similar relation between Persian language and Korean language (Park et al., 2019; Kim and Park, 2022). And now, the present researcher tried to know if there is close relation between Korean language and Persian language. The present researcher selected several Persian words randomly, and compared them with Korean words. The researcher used the Dictionary of Persian/French and French/Persian (Bau, 2008) in order to study the relation between Korean language and Persian language. The title is ‘Are they similar or are they same origin, Persian language and Korean language? (0132-0144)’. The present researcher tried to compare 13 Persian words with Korean words. And the results obtained here is described as follows. <number Persian word (its meaning) Korean word (its meaning in English)> 0132 Gozashita (passed thing, before) Ggoza-eoss-da (I have stabbed, pinned, stuck) 0133 Gor (tomb) Golo-ganda (He or she is going to die, toward death) 0134 Gozar (passage for the river, for road) Gosat (a narrow alley, a small road in the village) 0135 Yunani (Greek, of Greece) Yunan-eul-ddeolda (make a big deal (out of), specially) 0136 Doxtar (daughter, girl) Ddog ddeol-eo-zyeo-yo (It was fallen as a present suddenly.) 0137 Hafez (The person who can memorize Koran) Yeobo! (Calling each other by husband and wife) 0138-1 Pomi (large) Gippeumi (A person who gives joy to others) 0138-2 Pomi (large) Yeppeumi (A person who is beautiful) 0139-1 Panah gah (refuge) Pinan ga! (You, take your refuge!) 0139-2 Panah gah (refuge) Pihae ga! (You, escape from here!) 0140 Awi (Look at the thing!) Ayu! (Oh!) 0141 Hawi (I am afraid of the thing!) Huyu! (I am afraid of the thing!) 0142 Ajala (Make haste!) Ap-zil-leo (You, become faster than others!) 0143 Amma (but, at any case) Omma (My mother! No, it is not such a thing!) 0144 Shora (meeting) Seora (You, stop!) From this study, it is considered that there is a close relationship between Persian language and Korean language.
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Leslie, Amy R., Shu Ning, Leandro S. D'Abronzo, Cameron Armstrong, Masuda Sharifi, Zachary A. Schaaf, Wei Lou i in. "Abstract 3862: IGFBP3 promotes resistance to olaparib via modulating EGFR signaling in advanced prostate cancer". Cancer Research 83, nr 7_Supplement (4.04.2023): 3862. http://dx.doi.org/10.1158/1538-7445.am2023-3862.
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Abstract Background: Castration-resistant prostate cancer (CRPC) is an incurable disease and a leading cause of cancer death in men worldwide. Olaparib (Lynparza) was among the first PARP inhibitors (PARPi) approved for the treatment of CRPC tumors harboring DNA repair defects. However, clinical resistance to PARPi’s has been documented. The mechanisms underlying resistance to PARPi’s remain elusive. To study acquired resistance, we developed olaparib-resistant LN-OlapR and 2B-OlapR cell lines generated through chronic olaparib treatment of the olaparib-sensitive cell lines LNCaP and C4-2B, respectively. RNA-seq revealed IGFBP3 is overexpressed in both OlapR cell lines. IGFBP3 overexpression is correlated with poor clinical outcome and is thought to participate in DNA repair pathways. IGFBP3 plays a key role in nonhomologous end joining (NHEJ) repair through a ternary complex with EGFR and DNA-PKcs. The IGFBP3/EGFR signaling axis is thought to modulate NHEJ repair and could have implications for PARPi sensitivity. We hypothesize that increased IGFBP3 expression promotes PARPi resistance by enhancing DNA repair capacity. Methods: RNA-sequencing and gene set enrichment analysis were used to determine the expression profile changes in resistant cells compared to parental cells. Real time PCR and western blots confirmed the expression of DNA damage repair genes such as γH2AX, EGFR, and DNA-PKcs. ELISA was used to determine IGFBP3 secretion. RNAi was used to inhibit IGFBP3 and EGFR expression. Gefitinib was used to inhibit EGFR activity. Cell viability assays were used to assess cell growth. Results: Transcriptomic profiling revealed that IGFBP3 is highly expressed in resistant models. We verified increased levels of IGFBP3 RNA and protein in both OlapR models. We found that RNAi inhibition of IGFBP3 increases γH2AX and cleaved-PARP protein levels in the resistant models, which suggests accumulation of DNA double strand breaks (DSBs) leading to genomic instability and cell death. We discovered increased phosphorylation of EGFR and DNA-PKcs in the resistant cells. Furthermore, silencing/inhibiting IGFBP3 and EGFR reduces OlapR cell viability and resensitizes resistant cells to treatment. Conclusions: Our findings demonstrated that inhibiting IGFBP3 and EGFR aids in PARPi sensitivity in the resistant setting. Future work will utilize OlapR models to study how the IGFBP3/EGFR/DNA-PKcs protein complex promotes the development of resistance. Understanding the role of IGFBP3 in PARPi resistance will enhance our ability to re-sensitize resistant CRPC to PARPi therapeutics. Citation Format: Amy R. Leslie, Shu Ning, Leandro S. D'Abronzo, Cameron Armstrong, Masuda Sharifi, Zachary A. Schaaf, Wei Lou, Christopher P. Evans, Hong-Wu Chen, Alan Lombard, Allen C. Gao. IGFBP3 promotes resistance to olaparib via modulating EGFR signaling in advanced prostate cancer. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 3862.
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Rahman, Mohammad L., Charles E. Breeze, Xiao-Ou Shu, Jason YY Wong, Andres Cardenas, Xuting Wang, Bu-Tian Ji i in. "Abstract 3483: Epigenome-wide association study of lung cancer among never-smokers in two prospective cohorts in Shanghai". Cancer Research 83, nr 7_Supplement (4.04.2023): 3483. http://dx.doi.org/10.1158/1538-7445.am2023-3483.
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Abstract Background: The etiology of lung cancer among never-smokers has not been adequately elucidated despite that globally15% of lung cancer cases in men and 53% in women are not smoking-related. Epigenetic modifications, including changes in DNA methylation (DNAm), have been suggested as possible underlying mechanisms. However, only a few prospective epigenome-wide association studies (EWAS) of lung cancer incidence have been conducted, all exclusively focused on DNAm in peripheral blood cells and included a minimal number of never-smokers. We aimed to investigate genome-wide DNAm associations and epigenetic age acceleration with future risk of lung cancer among never-smokers using pre-diagnostic oral rinse samples. Methods: We conducted a case-control study of 80 never-smoking incident lung cancer cases and 83 comparable never-smoking controls nested in two large prospective cohorts: the Shanghai Women’s Health Study and Shanghai Men’s Health Study. DNAm was measured using the Illumina EPIC array. The top 50 differentially methylated positions (DMPs) were identified from a discovery sample and tested for replication in a validation sample using robust linear regression models. We also conducted an EWAS in the pooled sample. We examined functional overlap enrichment across chromatin states and histone mark broadPeaks for the top 1000 DMPs using eFORGE and constructed enrichment biological pathways analyses. Results: Across discovery and pooled EWAS, we identified four DMPs associated with lung cancer at the epigenome-wide significance level of P<8.0x10-8 (cg01411366: SLC9A10, P=7.23x10-08; cg00811020: NAA30, P=3.95x10-08; cg05658193: EIF2A, SERP1, P=5.02x10-08; and cg09198866: unannotated, P=5.39x10-09). The top 1000 DMPs were significantly enriched in epithelial regulatory regions and were associated with small GTPase-mediated signal transduction pathways. Furthermore, epigenetic age acceleration, measured by the GrimAge clock was prospectively associated with an increased risk of lung cancer (OR=1.19 per year of acceleration; 95% CI: 1.06-1.34) in logistic regression models. Conclusions: To our knowledge, this is the first prospective EWAS of lung cancer among never-smokers using oral rinse samples. Our results show that DNAm in pre-diagnostic oral rinse samples can provide new insights into lung cancer etiology and risk factors. Citation Format: Mohammad L. Rahman, Charles E. Breeze, Xiao-Ou Shu, Jason YY Wong, Andres Cardenas, Xuting Wang, Bu-Tian Ji, Wei Hu, Batel Blechter, Qiuyin Cai, H Dean Hosgood, Gong Yang, Jianxin Shi, Jirong Long, Yu-Tang Gao, Douglas Bell, Wei Zheng, Qing Lan, Nathaniel Rothman. Epigenome-wide association study of lung cancer among never-smokers in two prospective cohorts in Shanghai [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 3483.
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Leslie, Amy R., Allen C. Gao, Alan P. Lombard i Shu Ning. "Abstract B076: IGFBP3 promotes resistance to olaparib via modulating EGFR signaling in advanced prostate cancer". Cancer Research 83, nr 11_Supplement (2.06.2023): B076. http://dx.doi.org/10.1158/1538-7445.prca2023-b076.
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Abstract Background: Castration-resistant prostate cancer (CRPC) is an incurable disease and a leading cause of cancer death in men worldwide. Olaparib (Lynparza) was among the first PARP inhibitors (PARPi) approved for the treatment of CRPC tumors harboring DNA repair defects. However, clinical resistance to PARPi’s has been documented. The mechanisms underlying resistance to PARPi’s remain elusive. To study acquired resistance, we developed olaparib-resistant LN-OlapR and 2B-OlapR cell lines generated through chronic olaparib treatment of the olaparib-sensitive cell lines LNCaP and C4-2B, respectively. RNA-seq revealed IGFBP3 is overexpressed in both OlapR cell lines. IGFBP3 overexpression is correlated with poor clinical outcome and is thought to participate in DNA repair pathways. IGFBP3 plays a key role in nonhomologous end joining (NHEJ) repair through a ternary complex with EGFR and DNA-PKcs. The IGFBP3/EGFR signaling axis is thought to modulate NHEJ repair and could have implications for PARPi sensitivity. We hypothesize that increased IGFBP3 expression promotes PARPi resistance by enhancing DNA repair capacity. Methods: RNA-sequencing and gene set enrichment analysis were used to determine the expression profile changes in resistant cells compared to parental cells. Real time PCR and western blots confirmed the expression of DNA damage repair genes such as γH2AX, EGFR, and DNA-PKcs. ELISA was used to determine IGFBP3 secretion. RNAi was used to inhibit IGFBP3 and EGFR expression. Gefitinib was used to inhibit EGFR activity. Cell viability assays were used to assess cell growth. Results: Transcriptomic profiling revealed that IGFBP3 is highly expressed in resistant models. We verified increased levels of IGFBP3 RNA and protein in both OlapR models. We found that RNAi inhibition of IGFBP3 increases γH2AX and cleaved-PARP protein levels in the resistant models, which suggests accumulation of DNA double strand breaks (DSBs) leading to genomic instability and cell death. We discovered increased phosphorylation of EGFR and DNA-PKcs in the resistant cells. Furthermore, silencing/inhibiting IGFBP3 and EGFR reduces OlapR cell viability and resensitizes resistant cells to treatment. Conclusions: Our findings demonstrated that inhibiting IGFBP3 and EGFR aids in PARPi sensitivity in the resistant setting. Future work will utilize OlapR models to study how the IGFBP3/EGFR/DNA-PKcs protein complex promotes the development of resistance. Understanding the role of IGFBP3 in PARPi resistance will enhance our ability to re-sensitize resistant CRPC to PARPi therapeutics. Citation Format: Amy R. Leslie, Allen C. Gao, Alan P. Lombard, Shu Ning. IGFBP3 promotes resistance to olaparib via modulating EGFR signaling in advanced prostate cancer [abstract]. In: Proceedings of the AACR Special Conference: Advances in Prostate Cancer Research; 2023 Mar 15-18; Denver, Colorado. Philadelphia (PA): AACR; Cancer Res 2023;83(11 Suppl):Abstract nr B076.
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Ɗangulbi, Aliyu Rabi’u, Musa Abdullahi i Isah Sarkin Fada. "Mazarƙwaila Da Maɗi A Mahangar Al’ada Da Zamani". IAR Journal of Humanities and Social Science 3, nr 02 (20.04.2022): 50–56. http://dx.doi.org/10.47310/iarjhss.2022.v03i02.007.
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Maƙasudin wannan bincike shi ne a fito da daɗaɗɗiyar sana’ar mazarƙwaila da maɗi a idon al’umma dangane da sauye-sauyen zamani da aka samu a cikin sana’ar. Haka kuma binciken ya taƙaita ne a garuruwan ‘Yanware da Hayin Alhaji a ƙaramar hukumar Tsafe. Bugu da ƙari, an yi amfani da hanyoyi daban-daban da suka haɗa da ziyarar gani da ido a wuraren da ake gudanar da sana’ar da kuma tattaunawa da masu ruwa da tsaki a kan wannan sana’a. Har wa yau, binciken ya yi ƙoƙarin tattaro bayanai daga masana wannan fanni domin fito da ingantattun bayanai dangane da yadda ake sarrafa rake zuwa mazarƙwaila da maɗi, da kuma kasuwancinsu. Har wa yau an yi amfani da ayyukan magabata kama daga littattafai da maƙalu da kundayen bincike da suke da alaƙa da wannan bincike. Daga ƙarshe, binciken ya gano alfanu da illoli da suka jiɓinci wannan sana’a ta mazarƙwaila da maɗi.
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Qadeer, Muhammad Abdul. "Nason Al’adu Cikin Adabi: Nazarin Abincin Hausawa Na Gargajiya A Rubutattun Waƙoƙin Hausa". Tasambo Journal of Language, Literature, and Culture 2, nr 02 (15.06.2023): 159–66. http://dx.doi.org/10.36349/tjllc.2023.v02i02.018.
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Hausawa suna da abincinsu na gargajiya iri daban-daban da suka gada daga iyaye da kakanni, waɗanda suka riƙe a matsayin cimakarsu ta yau da kullum. Babban muradin wannan muƙala shi ne, ta fito da yadda ire-iren abincin Hausawa na gargajiya ya yi naso cikin rubutattun waƙoƙin Hausan. An ɗora aikin ne a kan ra’in nason al’adu a cikin adabi. Bugaggun littattafai da kundayen bincike da mujallu da muƙalu da fasahar sadarwa ta zamani suna daga cikin hanyoyin da aka yi amfani da su wajen tattara bayanai na wannan bincike. A waƙoƙin da aka nazarta, an gano ire-iren abincin Hausawa na gargajiya iri daba-daban har guda hamsin da tara da suka yi naso cikin rubutattun waƙoƙin da aka yi nazarta.
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Wang, Cong, Hui Cai, Qiuyin Cai, Jie Wu, Rachael Stolzenberg-Solomon, Clair Zhu, Yu-Tang Gao i in. "Abstract LB109: Circulating miRNA as biomarkers for pancreatic cancer early detection". Cancer Research 82, nr 12_Supplement (15.06.2022): LB109. http://dx.doi.org/10.1158/1538-7445.am2022-lb109.
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Abstract Pancreatic cancer is one of the most fatal human cancers, with an overall 5-year survival rate of 10.8%. Early detection is critical for improving pancreatic cancer prognosis, but biomarkers for early detection are lacking. We conducted a two-stage study to identify circulating miRNAs as biomarkers for pancreatic cancer early detection using pre-diagnostic plasma samples, collected within 5 years prior to cancer diagnosis, from case-control studies nested in five prospective studies. The discovery stage included 185 case-control pairs from the Prostate, Lung, Colorectal and Ovarian Cancer (PLCO) Screening Trial. Replication stage samples comprised 277 case-control pairs from diverse cohorts: Shanghai Women’s and Men’s Health Studies, Southern Community Cohort Study (SCCS), and Multiethnic Cohort. Controls were individually matched on age at enrollment, sex, recruitment site (SCCS), race/ethnicity, and date of blood draw in each cohort. Cell-free small RNAs were extracted from plasma samples and miRNAs were measured by the NanoString nCounter Analysis System using the Human v3 miRNA Expression panel (a total of 798 miRNAs). Normalized miRNAs were categorized by decile. For miRNAs that have ≥10% samples with an undetectable level (0), the non-zero level was categorized by approximately 10% increment. Associations of circulating miRNAs with pancreatic cancer risk, measured in odds ratios (ORs) and 95% confidence intervals (CIs) per decile change, were calculated using conditional logistic regression analyses in discovery and replication studies, separately within each cohort, and results meta-analyzed. We identified three miRNAs, hsa-miR-199a-3p+/hsa-miR-199b-3p, hsa-miR-191-5p, hsa-miR-767-5p, being consistently associated with pancreatic risk in both discovery and replication sets, with combined ORs (95% CIs) of 0.89 (0.84-0.95), 0.90 (0.85-0.95), and 1.08 (1.02-1.13), and P of 9.09E-05, 6.95E-05 and 4.03E-03, respectively. Adjustment for age, BMI, smoking, diabetes and family history of pancreatic cancer did not change the associations. Stratified analyses by age at diagnosis found five additional replicated miRNAs: hsa-miR-640, hsa-miR-1299, hsa-miR-22-3p, hsa-miR-874-5p, and hsa-miR-449b-5p among those 65 years or older, with combined ORs (95% CIs) of 1.33 (1.16-1.52), 1.28 (1.12-1.46), 0.76 (0.65-0.89), 1.25 (1.09-1.43), and 1.22 (1.07-1.39), and P-value ranging from 4.75E-05 to 0.003. These results suggest that circulating miRNA biomarkers may be useful in identifying individuals with high risk of developing pancreatic cancer for close surveillance and/or a screening test. Citation Format: Cong Wang, Hui Cai, Qiuyin Cai, Jie Wu, Rachael Stolzenberg-Solomon, Clair Zhu, Yu-Tang Gao, Jordan Berlin, Fei Ye, Wei Zheng, Veronica W. Setiawan, Xiao-Ou Shu. Circulating miRNA as biomarkers for pancreatic cancer early detection [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr LB109.
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Ning, Shu, Wei Lou, Chengfei Liu, Joy C. Yang, Alan P. Lombard, Leandro S. Abronzo, Neelu Batra, Aiming Yu, Christopher P. Evans i Allen C. Gao. "Abstract 3069: Targeting noncanonical Wnt5a signaling suppresses the neural lineage network and overcomes enzalutamide resistance in advanced prostate cancer". Cancer Research 83, nr 7_Supplement (4.04.2023): 3069. http://dx.doi.org/10.1158/1538-7445.am2023-3069.
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Abstract Introduction and Objectives: Androgen receptor (AR) blockade using antiandrogens is a mainstay for the treatment of castration-resistant prostate cancer (CRPC). However, resistance to antiandrogens occurs unavoidably due to the escaping mechanisms of tumor cells that are not completely understood. Upregulation of non-canonical Wnt ligand Wnt5a is identified from circulating tumor cells from CRPC patients after being treated with enzalutamide. FZD2, the cognate frizzled receptor for Wnt5a, is the most commonly co-upregulated non-canonical Wnt signaling molecule in prostate cancer. In this study, we determined the role of non-canonical Wnt5a/FZD2 to enzalutamide resistance and neural lineage plasticity, and explore the potential of targeting Wnt5a/FZD2 to overcome resistance in advanced prostate cancer. Methods: Wnt5a and FZD2 expression was determined in enzalutamide-resistant C4-2B MDVR cells. Wnt5a and FZD2 expressions were modulated using specific siRNAs. Cell growth, colony formation, and migration were studied in vitro. Transcriptomic analysis was performed on C4-2B MDVR cells treated with FZD2 knocked down; gene program of non-canonical Wnt signaling, hallmark androgen response and AR-V7 associated genes, and neural lineage pathways were analyzed. A novel tRNA bioengineered Wnt5a siRNA was developed to target Wnt5a/FZD2 signaling. The effect of tRNA-siWnt5a on tumor growth, sensitivity to enzalutamide treatment, and neural lineage plasticity was evaluated in vitro and in vivo. Results: Wnt5a and FZD2 are highly upregulated in castration-resistant prostate cancer patients, which is verified overexpression in enzalutamide-resistant C4-2B MDVR cells. Knocking down Wnt5a and FZD2 diminishes the enrichment of the non-canonical Wnt signaling pathway. Downregulating Wnt5a and FZD2 expression by specific siRNAs suppresses prostate cancer cell proliferation and resensitized C4-2B MDVR cells to enzalutamide treatment. Suppressing Wnt5a and FZD2 abrogated the enrichment of gene programs regulating cancer cell survival/proliferation, and neural lineage pathways including neuron differentiation and embryonic stem cell markers. Using the bioengineered tRNA-Wnt5a siRNA effectively inhibited the growth of enzalutamide-resistant prostate cancer cells and resensitized tumor cells to enzalutamide treatment in vitro, and resistant CRPC PDX LuCaP35CR tumor growth in vivo. Conclusions: Our results suggest that activation of noncanonical Wnt5a/FZD2 signaling confers to enzalutamide resistance and neural lineage plasticity. Targeting the Wnt5a signal could provide benefits for CRPC patients with tumors expressing a high level of Wnt5a, FZD2, and lineage markers, not only enhancing the anti-tumor effects of enzalutamide but suppressing the potential of neuroendocrine differentiation in advanced prostate cancer patients. Citation Format: Shu Ning, Wei Lou, Chengfei Liu, Joy C. Yang, Alan P. Lombard, Leandro S. Abronzo, Neelu Batra, Aiming Yu, Christopher P. Evans, Allen C. Gao. Targeting noncanonical Wnt5a signaling suppresses the neural lineage network and overcomes enzalutamide resistance in advanced prostate cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 3069.
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Ning, Shu, Wei Lou, Chengfei Liu, Alan Paul Lombard, Leandro S. D' Abronzo, Neelu Batra, Aiming Yu, Christopher P. Evans i Allen Gao. "Abstract B023: Targeting noncanonical Wnt5a signaling suppresses the neural lineage network and overcomes enzalutamide resistance in advanced prostate cancer". Cancer Research 83, nr 11_Supplement (2.06.2023): B023. http://dx.doi.org/10.1158/1538-7445.prca2023-b023.
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Abstract INTRODUCTION AND OBJECTIVES Androgen receptor (AR) blockade using antiandrogens is a mainstay for the treatment of castration-resistant prostate cancer (CRPC). However, resistance to antiandrogens occurs unavoidably due to the escaping mechanisms of tumor cells that are not completely understood. Upregulation of non-canonical Wnt ligand Wnt5a is identified from circulating tumor cells from CRPC patients after being treated with enzalutamide. FZD2, the cognate frizzled receptor for Wnt5a, is the most commonly co-upregulated non-canonical Wnt signaling molecule in prostate cancer. In this study, we determined the role of non-canonical Wnt5a/FZD2 to enzalutamide resistance and neural lineage plasticity, and explore the potential of targeting Wnt5a/FZD2 to overcome resistance in advanced prostate cancer. METHODS Wnt5a and FZD2 expression was determined in enzalutamide-resistant C4-2B MDVR cells. Wnt5a and FZD2 expressions were modulated using specific siRNAs. Cell growth, colony formation, and migration were studied in vitro. Transcriptomic analysis was performed on C4-2B MDVR cells treated with FZD2 knocked down; gene program of non-canonical Wnt signaling, hallmark androgen response and AR-V7 associated genes, and neural lineage pathways were analyzed. A novel tRNA bioengineered Wnt5a siRNA was developed to target Wnt5a/FZD2 signaling. The effect of tRNA-siWnt5a on tumor growth, sensitivity to enzalutamide treatment, and neural lineage plasticity was evaluated in vitro and in vivo. RESULTS Wnt5a and FZD2 are highly upregulated in castration-resistant prostate cancer patients, which is verified overexpression in enzalutamide-resistant C4-2B MDVR cells. Knocking down Wnt5a and FZD2 diminishes the enrichment of the non-canonical Wnt signaling pathway. Downregulating Wnt5a and FZD2 expression by specific siRNAs suppresses prostate cancer cell proliferation and resensitized C4-2B MDVR cells to enzalutamide treatment. Suppressing Wnt5a and FZD2 abrogated the enrichment of gene programs regulating cancer cell survival/proliferation, and neural lineage pathways including neuron differentiation and embryonic stem cell markers. Using the bioengineered tRNA-Wnt5a siRNA effectively inhibited the growth of enzalutamide-resistant prostate cancer cells and resensitized tumor cells to enzalutamide treatment in vitro, and resistant CRPC PDX LuCaP35CR tumor growth in vivo. Conclusions Our results suggest that activation of noncanonical Wnt5a/FZD2 signaling confers to enzalutamide resistance and neural lineage plasticity. Targeting the Wnt5a signal could provide benefits for CRPC patients with tumors expressing a high level of Wnt5a, FZD2, and lineage markers, not only enhancing the anti-tumor effects of enzalutamide but suppressing the potential of neuroendocrine differentiation in advanced prostate cancer patients. Citation Format: Shu Ning, Wei Lou, Chengfei Liu, Alan Paul Lombard, Leandro S. D' Abronzo, Neelu Batra, Aiming Yu, Christopher P. Evans, Allen Gao. Targeting noncanonical Wnt5a signaling suppresses the neural lineage network and overcomes enzalutamide resistance in advanced prostate cancer [abstract]. In: Proceedings of the AACR Special Conference: Advances in Prostate Cancer Research; 2023 Mar 15-18; Denver, Colorado. Philadelphia (PA): AACR; Cancer Res 2023;83(11 Suppl):Abstract nr B023.
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Isah, Salima Suleiman. "Nazari a Kan Sauye-Sauyen Ɗafi a Cikin Jam’in Kalmomin Yara". Tasambo Journal of Language, Literature, and Culture 2, nr 02 (15.06.2023): 134–42. http://dx.doi.org/10.36349/tjllc.2023.v02i02.015.
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Samuwar harshe na ɗaya daga cikin abubuwan ban mamaki na hallitar Ubangiji ga ɗan Adam. Haka ya sa aka himmatu ga nazarin yadda yara da manya ke sarrafa harshensu ta hanyoyi daban-daban. Jam’i a harshen Hausa yana ba da gagarumar gudunmuwa a harshen, domin ta hanyarsa ne ake tantance tilo, sannan ta hanyarsa ne ake gane ƙimarabu da adadi. Haka kuma, Jam’i ya kasance abu ne da ake aiwatar da shi yau da kullum. Domin da wuya a yi magana ɗaya ba tare da an aiwatar da shi ba. Manufar wannan maƙala ita ce nuna yadda yara sukan tsara jam’insu a harshen Hausa. An bi matakai na haƙiƙa wato zahiri wajen hanyar gudanar da wannan bincike wato wajen sauraron yara yayin furucinsu, ko kuma faɗin kalma, su kuma su ba da jam’inta gwargwadon fahimtarsu. An yi amfani da ra’in’Emergantism theory’ wato ra’i ne na ‘Machwinneys ’(1989) wanda ya yi nazari a kan harshen Ingilishi da Jamusanci, a inda ya nuna yadda yara suke sauye-sauyen ɗafi a jam’insu a tsakiyar kalma ko a ƙarshen kalma a waɗannan harsunan. Sakamakon bincike ya gano cewa, yara da ke a matakin shekaru takwas zuwa tara sukan tsara jam’insu a kan kuskure, ba tare da la’akari da sun yi daidai ba, ko akasin haka, domin kuwa su a wajensu daidai ne.
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Kumaraku, Llazar. "Global Architectural Fascism (GAF): The extreme case of MVRDV projects in Tirana". Science and the City. In the Era of Paradigm Shifts, nr 23 (1.10.2021): 96–97. http://dx.doi.org/10.37199/f40002310.
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When I was asked to write an opinion on the Downtown One building in Tirana designed by MVRDV I hesitated to give it. I hesitated because I remembered a piece of advice from my mom when I was young that always told me "if you can not talk about something well, it is better not to talk". I do not know how much I have followed this advice in my life but but, at least, I try to remember it often. My mom's advice was valuable at the time and I believe it is probably still valid today. Immediately after that, I started thinking about the reasons that lead a person to come out and give such advice. I found the answer to the fact that my mother was born immediately after the Second World War where in Albania the fascist and Nazi regimes had passed and then with a life spent in the communist dictatorship she could not build and could not have a critical spirit towards what surrounded her. This is because the critical spirit was suppressed and always denounced as agitation and propaganda. Immediately after this reasoning I set out to analyze the aspects of Fascism and Nazism that in a certain way formed the main ideologies of the first half of the 20th century and which, together with communism, must have influenced my mother's mentality and a major part of the society that was born in the second half of the last century.
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Smith (Xu, Robert Paul, i Ke Shu). "Kintanti kinų tapatybė globalėjančiame pasaulyje". Informacijos mokslai 45 (1.01.2008): 122–30. http://dx.doi.org/10.15388/im.2008.0.3378.
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Visuotiniame pasaulyje kinta kultūrinis žemėlapis. Greita ekonomikos plėtra skatina kinų kultūros pokyčius. Jaunimui būdingas individualumas, silpni giminystės ryšiai, meilės, sekso ir vedybų politikos pokyčiai. Dėl gimimų skaičiaus ribojimo Kinijoje vaikai ir jaunimas labiau linkę būti individualistai nei kolektyviški, tai skatinama ir per filmus ar televizijos serialus. Dažniau jie galvoja apie save nei apie Jus ar Juos. Giminystės ryšiai Kinijoje taip pat silpni, todėl šiame darbe daroma prielaida, kad būtent dėl tokių priežasčių 2006 m. labai padaugėjo santuokų su užsieniečiais. Taip pat tai atsiliepia ir vertinant požiūrį į partnerį. Kaip teigia pranešimo autorius, tai turi įtakos ir santuokai, seksualiniams santykiams.Chinese changing identities in globalised worldRobert Paul Smith (Xu, Ke Shu) SummaryThe cultural map is changing in the globalised world. The quickly developing economy changes the identities of Chinese quietly. Typically, the young generation is more individualistic, the traditional kinship weakens, and the ideology on love, sex and marriage changes. Because of Chinese birth control policy, the children and young people who grow up as the only child in her or his family respect individualism more than collectivism influenced by movies of Hollywood and Western TV soap plays. What they think most is in terms of “I”, not “you” or “they”. Kinship in China is now much weaker in Mainland China than it was in the past. In fact, there are many empty-nest families, in which children have left home to seek success in metropolis in China and cities in Foreign Countries, and their old, sick parents are suffering in loneliness. In the Chinese countryside, a lot of young couples refuse to support their old parents. Some old parents are even driven out and suffer from hunger. Now in China, DINK marriages and sexless marriages are common in the cities. More than 400,000 Chinese people have married foreigners till 2006. In 2005, more than 70,000 Japanese men and 41,000 Korean men have married Chinese women. Rich men change girlfriends or sex partners frequently. Some even keep special, private houses where their girlfriends live apart from their wives. Thousands of workers, drawn from farms to jobs in the cities, are sexually hungry and visit illegal striptease shows frequently. The new generation of Chinese people does not even value virginity very highly. There are too many quick marriages in China now. This was especially true in the lucky wedding year of 2006. Some married quickly and divorced very soon.Key words: change, identities, individualization, kinship, loven>
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Sani, Abu-Ubaida, i Sani Adamu. "Daga Hausar Rukuni Zuwa Ɓoyayyiyar Al’ada: Keɓaɓɓen Nazari A Kan Hausar Telolin Garin Gusau". Tasambo Journal of Language, Literature, and Culture 2, nr 02 (15.06.2023): 115–23. http://dx.doi.org/10.36349/tjllc.2023.v02i02.013.
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Wannan bincike ya ta’allaƙa ne kan nazarin Hausar teloli. Manufar binciken shi ne nazartar ire-iren kalmomi da jimloli da teloli ke amfani da su ta hanyar ba su ma’anonin da suka bambanta da maganar yau da kullum. Kadadar binciken ta taƙaita a garin Gusau da ke jahar Zamfara. An yi amfani da tattaunawa a matsayin babbar hanyar tattara bayanai. A bisa haka ne aka yi hira da teloli daban- daban da ke garin Gusau. Binciken ya gano cewa, akwai kalmomi da jimloli daban-daban da telolin ke amfani da su waɗanda suka bai wa ma’anonin da suka bambanta da na gama-gari. Waɗansu kuwa sukan kasance ƙirƙira ce kai tsaye. Binciken ya kalli wannan a matsayin wani abinci a fagen nazarin harshe da al’ada. Kundace su da nazartar su mataki ne na bunƙasa harshe tare da taskacewa da daidaita al’ada musamman yayin fito da tasirin amfani da iren-iren waɗannan Hausar ta rukuni ga zamantakewa.
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Lin, Shu, Zuwen Zhou, Rui Tan, Hua Xu, Huajie Zhang, Weipeng Zhang, Ling Chen i in. "Abstract 5453: FCN-289, a novel, potent and selective PI3Kδ inhibitor for the treatment of B-cell malignancies". Cancer Research 82, nr 12_Supplement (15.06.2022): 5453. http://dx.doi.org/10.1158/1538-7445.am2022-5453.
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Abstract Phosphoinositide 3-kinase (PI3K)/AKT/mTOR pathway plays critical roles in cell growth, differentiation, motility, survival, and intracellular trafficking, and is one of the most frequently dysregulated pathways in human cancers including B-cell malignancies. There are 3 classes of PI3K, among which Class I PI3Ks including PI3Kα, β, γ, and δ isoforms are the mostly studied and plays key roles in physiological functions. PI3Kα has a role in insulin-dependent signaling, PI3Kβ functions in platelet aggregation, thrombosis and insulin signaling, and PI3Kγ/δ are expressed mainly in leukocytes and regulate lymphocyte activation, mast cell degranulation, and chemotaxis. Early PI3K inhibitors such as idelalisib are effective against B-cell malignancies such as chronic lymphocytic leukemia, but their clinical use is largely limited due to intolerable toxicities. More selective PI3Kδ inhibitors such as umbralisib (TGR-1202) demonstrates improved clinical efficacy and safety profile compared to current standard of care and was recently approved as a monotherapy for follicular lymphoma and marginal zone lymphoma. However, there is still unmet medical need for novel PI3Kδ inhibitors with improved safety profile and better efficacy to be used as monotherapy and in suitable combination strategies. Here we introduce FCN-289, a novel and oral next-generation PI3Kδ inhibitor. FCN-289 demonstrates potent kinase activity against PI3Kδ with single-digit nanomolar IC50 and remarkably improved selectivity over other PI3K isoforms compared with TGR-1202. FCN-289 exhibits significant anti-proliferating activity against various human diffuse large B-cell lymphoma (DLBCL)-derived cancer cell lines (OCI-LY10, TMD-8 and WSU-NHL) with superior activity compared with TGR-1202. Consistently, FCN-289 shows dose-dependent anti-tumor growth activity superior to that of TGR-1202 at the same and higher dose in TMD-8 DLBCL xenograft models. FCN-289 shows significantly improved anti-tumor activity when combined with BTK inhibitor ibrutinib in TMD-8 and OCI-LY10 DLBCL xenograft models. In non-clinical settings, FCN-289 exhibits good pharmacokinetic (PK) and safety properties with shorter Tmax and higher bioavailability in both rats and dogs, higher exposure in rats, improved CYP450 inhibition profile, and less plasma protein bound ratio compared with TGR-1202.Together, FCN-289 is a novel PI3Kδ inhibitor that possesses more potent in vitro and in vivo anti-cancer activities in B-cell malignancies-derived models with improved selectivity against other PI3K isoforms compared with TGR-1202. Combination with ibrutinib further improves anti-tumor activity compared with monotherapy. FCN-289 shows favorable PK and safety profiles compared with TGR-1202. Our findings highlight the therapeutic potential of FCN-289 as a novel targeted approach as monotherapy or in combination for treating B-cell malignancies. Citation Format: Shu Lin, Zuwen Zhou, Rui Tan, Hua Xu, Huajie Zhang, Weipeng Zhang, Ling Chen, Lijun Yang, Xingdong Zhao, Yanxin Liu, Zongyao Zou, Yuwei Gao, Jiashu Zhou, Weibo Wang. FCN-289, a novel, potent and selective PI3Kδ inhibitor for the treatment of B-cell malignancies [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 5453.
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Zhao, Yingya, Xiao-Ou Shu, Yu-Tang Gao, Mark M. Kushnir, Qiuyin Cai, Hui Cai, Qing Lan, Nathaniel Rothman, Wei Zheng i Gong Yang. "Abstract 6491: Temporal changes in circulating sex hormones and aromatase activity and associations with lung cancer survival in postmenopausal women". Cancer Research 83, nr 7_Supplement (4.04.2023): 6491. http://dx.doi.org/10.1158/1538-7445.am2023-6491.
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Abstract Background: Exogenous sex hormone supplements had been associated with increased lung cancer mortality in a large clinical trial. No study to date has evaluated temporal trajectories of circulating sex hormones and aromatase activity and their associations with lung cancer survival. Objective: To characterize temporal changes in prediagnostic levels of circulating sex hormones and aromatase activity and to evaluate their associations with overall survival in lung cancer patients. Methods: Included in the analysis were 385 incident lung cancer patients identified in a large prospective cohort among postmenopausal women who had never used cigarette products nor exogenous sex hormone supplements. Concentrations of sex hormones were quantitated using LC-MS/MS assays in prediagnostic plasma samples. The product-substrate molar ratio of estrone to androstenedione was used as an index of aromatase activity (IAA). A multivariable Cox model with restricted cubic spline functions was used to calculate hazard ratio (HR) for overall survival. Results: Of 385 patients with lung cancer, 308 died during a median follow-up of 18.1 years. Initial analyses in all patients showed that higher levels of circulating estrone and IAA and lower levels of androstenedione and testosterone were associated with poorer overall survival after adjusting for nonclinical covariates. In analyses restricted to those with clinical data (n=281), stronger associations were found after further adjustment for tumor stage and treatment regimens. Compared with patients at the median level of IAA, adjusted HRs (95% CI) for total mortality in those at the 30th, 70th, 90th and 95th percentiles were 0.98 (0.84-1.13), 1.05 (0.94-1.16), 1.28 (1.06-1.54), and 1.64 (1.27-2.12), respectively, with P-overall < 0.001. A similar positive association was observed for estrone. In contrast, inverse associations were seen for androgens. For example, compared with the median level of testosterone, HRs (95% CI) for those at the 5th, 10th, 30th, 70th percentiles were 2.10 (1.43-3.09), 1.69 (1.29-2.23), 1.45 (1.19-1.76), and 0.86 (0.78-0.94), respectively, with P-overall = 0.001. Further, we found that circulating levels of sex hormones changed during disease progression. The closer the hormone measurement to cancer diagnosis the higher the IAA and estrone levels (P-overall < 0.001 for both), and the temporal change plateaued 10 years before cancer diagnosis (P-nonlinearity < 0.001 for both). An opposite temporal pattern was found for testosterone. Moreover, the significant association between sex hormones and lung cancer survival was only observed when sex hormones were measured within 10 years before diagnosis. Conclusions: Findings from our study, for the first time, demonstrate temporal changes in circulating sex hormones and their associations with lung cancer survival in postmenopausal women. Citation Format: Yingya Zhao, Xiao-Ou Shu, Yu-Tang Gao, Mark M. Kushnir, Qiuyin Cai, Hui Cai, Qing Lan, Nathaniel Rothman, Wei Zheng, Gong Yang. Temporal changes in circulating sex hormones and aromatase activity and associations with lung cancer survival in postmenopausal women. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 6491.
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Lin, Shu (Sophie), Hongbin Liu, Rui Tan, Weipeng Zhang, Chengxi He, Yue Rong, Zhuo Huang i in. "Abstract 2531: FCN-683, a novel second-generation BCL-2 inhibitor, is highly potent, selective and efficacious against clinically relevant venetoclax-resistant mutations". Cancer Research 83, nr 7_Supplement (4.04.2023): 2531. http://dx.doi.org/10.1158/1538-7445.am2023-2531.
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Abstract B-cell lymphoma 2 (BCL-2) is a member of the anti-apoptotic BCL-2 family and is dysregulated in B-cell malignancies, including chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL), acute myeloid leukemia (AML) and Non-Hodgkin’s lymphoma. Venetoclax (VEN), also known as ABT-199, is the only BCL-2 inhibitor approved by FDA for treating CLL/SLL and AML. VEN is a BH3-mimetic drug competitively inhibits BCL-2 by binding to the hydrophobic groove and thereby displacing proapoptotic proteins and inducing apoptosis. Despite high effectiveness of the initial treatment, most patients treated with VEN eventually relapse or develop resistance. An important resistance mechanism is acquisition of BCL-2 G101V mutation, detected in about 50% of CLL patients 19-42 months after receiving VEN. Other resistance mutations identified clinically so far include D103, A113G, R129L, and V156D, etc. Overcoming VEN-resistant Bcl-2 mutations represent an unmet medical need. Here, we introduce a novel and selective second-generation oral BCL-2 inhibitor, FCN-683, with sub-nano or single nanomolar affinity to BCL-2 and VEN-resistant BCL-2 mutations including G101V, D103E/V/Y, F104L, A113G, R129L and V156D. FCN-683 showed much higher affinity to BCL-2 than BCL-xL, suggesting its good potential to avoid BCL-xL-linked thrombocytopenia. FCN-683 exhibited comparable or superior anti-proliferation activities compared with VEN in various BCL-2-addicted human B-cell lymphoma cells, including DOHH2 follicular lymphoma cells, Toledo diffuse large B-cell lymphoma cells, and RS4;11 acute lymphoblastic leukemia cells, while sparing BCL-xL-dependent cells. Of note, FCN-683 displayed potent anti-proliferative activities against a panel of genetically engineered RS4;11 cells ectopically expressing VEN-resistant BCL-2 mutants such as G101V, D103 or several other mutants above-mentioned, outperforming VEN. Correspondingly, FCN-683 significantly inhibited tumor growth in mice xenografts derived from human B-cell lymphomas harboring BCL-2 or various VEN-resistant BCL-2 mutations and its anti-tumor efficacy was much superior to VEN. In non-clinical studies, FCN-683 possessed excellent pharmacokinetic (PK) properties comparable to VEN. Preferable safety profiles of FCN-683 were shown with no potential hERG inhibitory effect and less drug-drug interaction potential, as evidenced by no inhibitory effect (IC50 >50 μM) on CYP2C9 enzyme compared with VEN (IC50 1.05 μM). Together, FCN-683 is highly potent, selective and highly efficacious against a variety of clinically relevant VEN-resistance BCL-2 mutations in vitro and in vivo and exhibits favorable PK and safety profiles, highlighting its therapeutic potential to become an effective therapeutic approach for VEN-naïve or -resistant BCL-2-addicted B-cell malignancies. Citation Format: Shu (Sophie) Lin, Hongbin Liu, Rui Tan, Weipeng Zhang, Chengxi He, Yue Rong, Zhuo Huang, Jinhua Yu, Yunling Wang, Yangli Qi, Xingdong Zhao, Lihua Jiang, Yanxin Liu, Xilei Wang, Zongyao Zou, Jing Sun, Yuwei Gao, Weibo Wang, Xiaohui Guan, Yifang Wu. FCN-683, a novel second-generation BCL-2 inhibitor, is highly potent, selective and efficacious against clinically relevant venetoclax-resistant mutations [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 2531.
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Cai, Hui, Veronica Wendy Setiawan, Xingyi Guo, Jie Wu, Rachael Z. Stolzenberg-Solomon, Claire Zhu, Yu-Tang Gao i in. "Abstract 468: Associations of circulating miRNAs with pancreatic cancer risk differ by years between blood collection & and cancer diagnosis". Cancer Research 84, nr 6_Supplement (22.03.2024): 468. http://dx.doi.org/10.1158/1538-7445.am2024-468.
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Abstract Pancreatic adenocarcinoma (PDAC) is one of the most fatal cancers and currently used biomarkers for PDAC diagnosis are not adequate for early detection. Therefore, new biomarkers for PDAC early detection are urgently needed. We conducted a large-scale study to prospectively evaluate the association of circulating miRNAs with PDAC risk. Specially, we aimed to examine whether the associations of miRNAs expression levels and changes of those levels from blood collection to cancer diagnosis (BCCD) with PDAC risk. We used pre-diagnostic plasma samples of 1307 PDAC cases from 5 cohort studies (290 from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial, 395 from the Shanghai Women’s and Men’s Health Studies, 154 from the Southern Community Cohort Study, and 468 from the Multiethnic Cohort). Cancer free controls (n=1307) were selected and individually matched to index cases in each cohort. All miRNAs were measured by the NanoString nCounter Analysis System using the Human v3 miRNA Expression panel (798 miRNAs total). Data were pooled and quantile normalized prior to analysis. Associations of circulating miRNAs with PDAC risk were assessed by odds ratio per decile change in miRNA levels using conditional logistic regression. Fold-change of miRNA for cases versus controls by BCCD was analyzed via linear regression. Median time of BCCD was 7.13 years (range: 0.03-19.61 years). We first conducted the association analysis stratified by BCCD: < 5 years, 5-10 years, and >10 years. We found 20 miRNAs were significantly associated with PDAC risk in the <5 years after FDR correction. In the analysis of regressing fold-change of these 20 miRNAs on BCCD, we found the fold change of miR-155-5p was inversely associated with BCCD (β=-0.04, P<0.01), i.e., the case-control difference was larger when blood was drawn closer to PDAC diagnosis, suggesting its potential utility as disease biomarkers for early detection. Conversely, the fold-change of miR-93-5p (β=0.04, P=0.01), miR-223-3p (β=0.03, P=0.02), let-7i-5p (β=0.03, P<0.01), and miR-191-5p (β=0.05, P<0.01) were positively associated with BCCD, i.e., the case-control difference increased with an increasing the time interval of BCCD, indicating they are more likely biomarkers for PDAC risk. Ingenuity pathway analyses of these five significant miRNAs revealed that they were significantly enriched in ribonucleotide reductase signaling pathways at p<0.05. Notably, the silencing of ribonucleotide reductase M2 subunit suppresses tumorigenesis in pancreatic cancer by deactivating the PI3K/AKT/mTOR pathway, further supporting our findings. Findings of this large-scale multiethnic study suggest that changes in circulating levels of let-7i-5p, miR-155-5p, miR-93-5p, miR-191-5p, and miR-223-3p may help identify individuals at an elevated risk of developing PDAC, allowing for screening tests and close surveillance. Citation Format: Hui Cai, Veronica Wendy Setiawan, Xingyi Guo, Jie Wu, Rachael Z Stolzenberg-Solomon, Claire Zhu, Yu-Tang Gao, Jordan Berlin, Fei Ye, Qiuyin Cai, Wei Zheng, Xiao-ou Shu. Associations of circulating miRNAs with pancreatic cancer risk differ by years between blood collection & and cancer diagnosis [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 468.
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Chen, Zhen, Hai-Peng Liang, Dominik Stepien, Ziyuan Lyu, Maider Zarrabeitia, Matthias Kuenzel, Fanglin Wu, Guk-Tae Kim, Stefano Passerini i Dominic Bresser. "Reinforcing the Li|Li1.3Al0.3Ti1.7(PO4)3 Interfacial Stability By an Ultrathin Multifunctional Polysiloxane-Based Single-Ion Conducting Polymer". ECS Meeting Abstracts MA2022-01, nr 2 (7.07.2022): 206. http://dx.doi.org/10.1149/ma2022-012206mtgabs.
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Lithium metal is considered as one of the most promising anode candidates for high-energy batteries [1-3]. However, safety concerns induced by the formation of Li dendrites largely hinder the practical application of lithium-metal batteries [4]. It is anticipated that the use of non-flammable inorganic solid-state electrolytes can resolve these safety issues [5], but solid ceramic electrolytes generally suffer from poor physical contact with the electrode and poor electro-/chemical stability at the electrolyte|electrode interface [6]. Herein, we report on a thin and flexible hybrid electrolyte composed of NASICON-type Li1.3Al0.3Ti1.7(PO4)3 (LATP), a polymer binder, and a small amount of an ionic liquid-based electrolyte. To reinforce the interfacial stability between LATP and Li, we coat an ultrathin polysiloxane-based single-ion conducting polymer (PSiO) on the Li metal surface via a simple dip-coating method. The implementation of PSiO-coated Li (PSiO@Li) in symmetric PSiO@Li||PSiO@Li cells enables a substantial extension of the cycle life, yielding >2,000 h of stable lithium stripping-plating. The full-cells comprising PSiO@Li as the negative electrode, LiNi0.88Co0.09Mn0.03O2 (NCM88) as the positive electrode active material, and the aforementioned hybrid electrolyte exhibit substantially enhanced rate capability at high dis-/charge rates above 0.5C and greatly prolonged cycle life at 1C. The superior performance achieved herein is mainly attributed to: (1) the prevented direct contact between LATP and Li, thus avoiding the reduction of LATP and the formation of mixed ion-electron conducting interphases; (2) the regulated Li+ flux at the electrode|electrolyte interface, ensuring homogeneous Li+ stripping-plating; and (3) the promoted intimate contact between PSiO and Li via the formation of Si−O−Li bonds. References [1] T. Li, X.-Q. Zhang, P. Shi, Q. Zhang, Joule, 3 (2019) 2647-2661. [2] B. Horstmann, J. Shi, R. Amine, M. Werres, X. He, H. Jia, F. Hausen, I. Cekic-Laskovic, S. Wiemers-Meyer, J. Lopez, D. Galvez-Aranda, F. Baakes, D. Bresser, C.-C. Su, Y. Xu, W. Xu, P. Jakes, R.-A. Eichel, E. Figgemeier, U. Krewer, J.M. Seminario, P.B. Balbuena, C. Wang, S. Passerini, Y. Shao-Horn, M. Winter, K. Amine, R. Kostecki, A. Latz, Energy Environ. Sci., 14 (2021) 5289-5314. [3] S. Wang, P. Xiong, J. Zhang, G. Wang, Energy Storage Materials, 29 (2020) 310-331. [4] Z. Yu, Y. Cui, Z. Bao, Cell Rep. Phy. Sci., 1 (2020) 100119. [5] S. Xin, Y. You, S. Wang, H.-C. Gao, Y.-X. Yin, Y.-G. Guo, ACS Energy Lett., 2 (2017) 1385-1394. [6] A. Banerjee, X. Wang, C. Fang, E.A. Wu, Y.S. Meng, Chem. Rev., 120 (2020) 6878-6933.