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Artykuły w czasopismach na temat "Wl 340.2"
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Naya, Yoshio, Masakatsu Oishi, Takashi Ueda, Yasuyuki Naitoh, Hiroyuki Nakanishi, Fumiya Hongo, Terukazu Nakamura, Kazumi Kamoi, Koji Okihara i Tsuneharu Miki. "Preliminary study of combined use of PDD and NBI for detection for flat urothelial lesion." Journal of Clinical Oncology 33, nr 7_suppl (1.03.2015): 340. http://dx.doi.org/10.1200/jco.2015.33.7_suppl.340.
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340 Background: This prospective preliminary study is a first report to compare photodynamic diagnosis (PDD) with narrow band imaging (NBI) in the same patients with flat suspicious lesions of carcinoma in situ (CIS) of bladder. Methods: PDD was approved by the ethics committees of our institution for 10 patients with non muscle invasive bladder cancer. Between November 2012 and April 2013, 10 patients with abnormal cytology (class III or more) but undefined papillary mucosa underwent TURBT using PDD and NBI in same time. Each patient received 1.0g ALA hydrochloride (Cosmo Bio Co., Tokyo, Japan) dissolved in 50 mL water, and was given orally 3 hours before the TURBT. The bladder was mapped first under white light (WL), then under NBI, and subsequently under blue light (BL) in odd-numbered patients. The bladder was mapped first under WL, then under BL, and subsequently under NBI in even- numbered patients. Biopsies were carried out from all suspicious areas noting if NBI, PDD or both detected lesions. Random cold cup biopsies were performed from negative lesions of PDD and NBI. Results: The sensitivity and specificity of PDD for detection CIS were 1.00 and 0.714, and those of NBI were 0.75 and 0.814, respectively. There were no cancer and dysplasia in 43 lesions both PDD and NBI negative. Of 50 lesions with negative PDD, only 2 (4%) were dysplasia and there was no cancerous lesion. Of 60 lesions with negative NBI, 3 (5%) were cancer and 6 (10%) were dysplasia. The AUC for detection CIS in PDD, in NBI and in combined use of PDD and NBI were 0.869, 0.782 and 0.964, respectively. Conclusions: When both PDD and NBI were negative, the possibility of CIS might be very low. The usefulness of the combination of PDD with NBI was suggested in this study. [Table: see text]
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Milani, Ilaria, Gloria Guarisco, Marianna Chinucci, Chiara Gaita, Frida Leonetti i Danila Capoccia. "Sex-Differences in Response to Treatment with Liraglutide 3.0 mg". Journal of Clinical Medicine 13, nr 12 (7.06.2024): 3369. http://dx.doi.org/10.3390/jcm13123369.
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Background: Sex differences characterize the prevalence and attitudes toward weight management. Despite limited evidence suggesting greater weight loss in women with anti-obesity pharmacotherapy, sex-specific analysis remains underexplored. This retrospective study aimed to evaluate the sex-specific response to liraglutide 3.0 mg treatment in people with obesity without type 2 diabetes (T2D). Methods: Data were collected from 47 patients (31 women, 16 men) with age > 18 years; BMI ≥ 30 kg/m2; absence of T2D; and exclusion of prior anti-obesity treatment, comorbidities, or bariatric surgery. Only patients who maintained the liraglutide 3.0 mg dose for at least 6 months were included. Results: Both sexes showed significant reductions in weight and BMI at 3 and 6 months. Men achieved greater weight loss (WL), BMI reduction, %WL, WL > 5%, and >10% than women, and they also showed more significant improvements in metabolic parameters (total and LDL cholesterol, Fibrosis-4 Index FIB-4). No significant sex differences were observed in glucose metabolism or renal function. Conclusions: This study showed a greater therapeutic effect of liraglutide 3.0 mg in men. Given men’s higher risk of cardiovascular disease (CVD), and underrepresentation in clinical weight loss programs, these findings may increase male engagement and improve their CVD risk.
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Zaleta, Alexandra Katherine, Shauna McManus, Thomas William LeBlanc i Joanne S. Buzaglo. "Perceptions of unintentional weight loss among cancer survivors." Journal of Clinical Oncology 36, nr 7_suppl (1.03.2018): 138. http://dx.doi.org/10.1200/jco.2018.36.7_suppl.138.
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138 Background: Unintentional weight loss (WL) can be a disruptive symptom of cancer, yet its psychosocial impact is not well understood. We examined cancer survivors’ experiences with unintentional WL. Methods: 320 cancer survivors completed an online survey, provided demographic, health, and unintentional WL history, and rated (0 = not at all; 4 = extremely) 19 statements about WL outcomes. We examined bivariate associations between weight status, unintentional WL, and WL outcomes. Results: Participants were 90% White; mean age = 58.8 years, SD= 11; 41% breast cancer, 23% blood cancer, 8% prostate cancer, mean time since diagnosis = 6.0 years, SD= 5; 18% metastatic, 22% current recurrence/relapse, 51% remission. 55 participants (17%) reported unintentional WL in the past 6 months (mean = 16lbs; range = 2-70; mean BMI = 27.6, SD= 6.3). These participants were less likely to be in disease remission ( p< .05). Participants with unintentional WL tended to underestimate their weight category (e.g., of BMI-classified healthy weight participants, 26% believed they were underweight); κ = -.17, p< .01. 51% of participants felt (somewhat to extremely) positive about WL, 49% said their health care team was supportive of WL; these statements were more strongly endorsed by people describing themselves as overweight ( ps < .05). 27% believed WL caused physical weakness, 23% said WL resulted in lost control over nutrition/eating, 16% said WL made them feel like a burden, 14% said WL caused them to lose their identity; these statements were more strongly endorsed by people describing themselves as underweight ( ps < .01). 20% viewed their WL as a sign of approaching end of life, 13% believed WL meant they would not be able to continue treatment; these views did not differ by perceived weight status. Conclusions: Many cancer survivors experience unintentional weight loss and associate their weight loss with negative outcomes. Survivors also often underestimate their weight status, which is notable given that personal views of one’s weight status, not BMI-derived weight status, is associated with beliefs about the impact of unintentional weight loss. Our findings suggest that people believe unintentional WL meaningfully affects their quality of life.
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Longchar, Lanuakum A., Mainur Rahaman, Binoy Krishna Hazra, M. Manivel Raja, R. Rawat, S. N. Kaul i S. Srinath. "Effect of film thickness on the electrical transport in Co2FeAl0.5Si0.5 thin films". AIP Advances 13, nr 2 (1.02.2023): 025106. http://dx.doi.org/10.1063/9.0000486.
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The effect of film thickness on the structural- and electrical-properties is investigated in Co2FeAl0.5Si0.5 (CFAS) thin films of thickness, t, in the range 12–75 nm. These films are grown by ultrahigh vacuum dc magnetron sputtering on Si(100) substrates with SiO2 buffer layer (300 nm), at the substrate temperature of 500 ◦C. The GIXRD patterns reveal that B2 structural order decreases with increasing t. The film with t = 75 nm has sizable A2 disorder. Irrespective of t, ρ(T, H = 0) goes through a minimum at T min. An elaborate quantitative analysis of the ρ(T, H = 0) data, taken over the temperature range 5 K to 300 K, demonstrates that the electron-diffuson ( e– d) and weak localization (WL) effects (responsible for the negative temperature coefficient of resistivity (TCR) for T < T min) compete with the electron-magnon ( e– m) and electron–phonon ( e– p) scattering ( positive TCR) contributions to produce a minimum at T min. Residual resistivity, ρ5K, and the e– d, wl, e– m and e– p scattering contributions to ρ(T, H = 0), ρ e– d, ρ wl, ρ e– m and ρ e– p, all go through a minimum at t = 50 nm. Regardless of t, the thermal renormalization of the spin-wave stiffness makes a significant contribution to ρ e– m.
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Cho, Il-Hyun, Yong-Jae Moon, Jin-Yi Lee, Junmo An, Dae Jung Yu, Kyung-Suk Cho, Harim Lee i Jae-Ok Lee. "Recurrently Propagating Intensity Disturbances along Polar Plumes Observed in White Light and Extreme Ultraviolet". Astrophysical Journal 961, nr 1 (1.01.2024): 128. http://dx.doi.org/10.3847/1538-4357/ad11d2.
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Abstract We study properties of intensity disturbances along polar coronal rays that are associated with plumes below. For this, we draw azimuth–time images of extreme ultraviolet (EUV) emission of 171 Å band observed by the SDO/AIA and white light (WL) observed by the SOHO/LASCO C2 in 2020 July. From the azimuth–time image, we define two tracks in which the EUV intensities were recurrently enhanced during two weeks. The two EUV tracks are rooted at 78.°8 and 81.°4 latitudes, but their projected azimuth angles are changed with time as the Sun rotates. Coherent WL tracks at different altitudes are determined by scaling the azimuth angles of the EUV tracks, accounting for the effect of inclination of coronal rays. From this, we construct time–distance images of WL intensities along WL tracks, whose projected azimuth angle changes along time and altitude, but the intensities are correlated with the EUV intensities measured below. The time–distance images of WL show repeated and inclined intensity features. The propagation speeds in the altitude range 2.3–6 solar radii are calculated to be 159 ± 8 km s−1 and 300 ± 24 km s−1. The EUV and WL intensities are found to be coherent at 1–2 day periods. It is also found that dynamic burst events along the EUV track are responsible for the enhanced emission. We conclude that the variation of the WL intensity along the polar coronal rays is related with the evolution of the EUV intensity below.
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Bao, Ting, Kimberly J. Van Zee, Barrie R. Cassileth, Marci Coleton, Qing Susan Li, Babak Mehrara, Emily Vertosick, Andrew J. Vickers i Jun J. Mao. "Acupuncture for breast cancer related lymphedema: A randomized controlled trial." Journal of Clinical Oncology 35, nr 15_suppl (20.05.2017): e21706-e21706. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.e21706.
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e21706 Background: Up to 20% of breast cancer survivors develop breast cancer related lymphedema (BCRL), and current therapies are limited. In a previous single armed study, acupuncture appeared to reduce BCRL. In this study, we compared our specific protocol of acupuncture (AC) to usual care wait list control (WL). Methods: Women with moderate persistent BCRL were randomized to AC or WL. The AC protocol included twice-weekly manual acupuncture over 6 weeks. The primary endpoint was change in circumference difference between affected/unaffected arms. Responders were defined as having > 30% improvement in arm circumference difference between arms. We also evaluated the change in difference between affected/unaffected arm bioimpedance. We used analysis of covariance for circumference and bioimpedance measurements and Fisher’s exact test for proportion of responders. Results: Among 82 patients, 73 (89%) were evaluable for the primary endpoint (36 in AC and 37 in WL). The median age in AC was 65 (IQR 54, 71) and 58 (IQR 49, 70) in WL. Most patients in both arms had undergone mastectomy (74%) and axillary lymph node dissection (96%), and had a history of prior lymphedema treatment (96%). Median duration of lymphedema was 2.2 years in AC (IQR 1.3, 3.0) and 2.5 years in WL (IQR 1.4, 3.4). We found no evidence of a difference in either arm circumference difference improvement (β -0.38cm, 95% CI -0.89, 0.12, p = 0.14) or bioimpedance difference improvement (β -1.06, 95% CI -7.85, 5.72, p = 0.8) between AC and WL at Week 6. There was also no difference in proportion of responders: 17% AC vs. 11% WL (6% difference, 95% CI -10%, 22%, p = 0.5). No severe adverse events (AE) were reported. Grade 1 treatment-related AEs such as bruising (58%), hematoma (2%), and pain (2%) were reported in patients receiving AC. Among the 837 acupuncture treatments provided, one possibly related grade 2 skin infection was reported. Conclusions: Although it appears to be safe and well tolerated, our acupuncture protocol did not offer additional clinically meaningful reductions in BCRL compared with usual care among patients who had received lymphedema treatment. This regimen should not be recommended for breast cancer survivors with persistent BCRL. Clinical trial information: NCT01706081.
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Song, Jian, Xinqun Hu, Osman Khan, Ying Tian, Joseph G. Verbalis i Carolyn A. Ecelbarger. "Increased blood pressure, aldosterone activity, and regional differences in renal ENaC protein during vasopressin escape". American Journal of Physiology-Renal Physiology 287, nr 5 (listopad 2004): F1076—F1083. http://dx.doi.org/10.1152/ajprenal.00075.2004.
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The syndrome of inappropriate antidiuretic hormone (SIADH) is associated with water retention and hyponatremia. The kidney adapts via a transient natriuresis and persistent diuresis, i.e., vasopressin escape. Previously, we showed an increase in the whole kidney abundance of aldosterone-sensitive proteins, the α- and γ (70-kDa-band)-subunits of the epithelial Na+ channel (ENaC), and the thiazide-sensitive Na-Cl cotransporter (NCC) in our rat model of SIADH. Here we examine mean arterial pressure via radiotelemetry, aldosterone activity, and cortical vs. medullary ENaC subunit and 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD-2) protein abundances in escape. Eighteen male Sprague-Dawley rats (300 g) were sham operated ( n = 6) or infused with desmopressin (dDAVP; n = 12, a V2 receptor-selective analog of AVP). After 4 days, one-half of the rats receiving dDAVP were switched to a liquid diet, i.e., water loaded (WL) for 5–7 additional days. The WL rats had a sustained increase in urine volume and blood pressure (122 vs. 104 mmHg, P < 0.03, at 7 days). Urine and plasma aldosterone levels were increased in the WL group to 844 and 1,658% of the dDAVP group, respectively. NCC and α- and γ-ENaC (70-kDa band) were increased significantly in the WL group (relative to dDAVP), only in the cortex. β- and γ-ENaC (85-kDa band) were increased significantly by dDAVP in cortex and medulla relative to control. 11β-HSD-2 was increased by dDAVP in the cortex and not significantly affected by water loading. These changes may serve to attenuate Na+ losses and ameliorate hyponatremia in vasopressin escape.
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de Toledo Leonardo, Renato, Gisselle Moraima Chávez-Andrade, Mario Tanomaru-Filho, Juliane Maria Guerreiro-Tanomaru, Lucas Martinati Miano i Fernanda Ferrari Esteves Torres. "Cleaning of Root Canal System by Different Irrigation Methods". Journal of Contemporary Dental Practice 16, nr 11 (2015): 859–63. http://dx.doi.org/10.5005/jp-journals-10024-1771.
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ABSTRACT Objective The aim of this study was to compare the cleaning of main and lateral canals using the irrigation methods: negative pressure irrigation (EndoVac system), passive ultrasonic irrigation (PUI) and manual irrigation (MI). Materials and methods Resin teeth were used. After root canal preparation, four lateral canals were made at 2 and 7 mm from the apex. Root canals were filled with contrast solution and radiographed pre- and post-irrigation using digital radiographic system [radiovisiography (RVG)]. The irrigation protocols were: MI1—manual irrigation [22 G needle at 5 mm short of working length-WL]; MI2—manual irrigation (30G needle at 2 mm short of WL); PUI; EV1—EndoVac (microcannula at 1 mm short of WL); EV2—Endovac (microcannula at 3 mm short of WL). The obtained images, initial (filled with contrast solution) and final (after irrigation) were analyzed by using image tool 3.0 software. Statistical analysis was performed by analysis of variance (ANOVA) and Tukey tests (5% significance level). Results EV1 and EV2, followed by PUI showed better cleaning capacity than manual irrigation (MI1 and MI2) (p < 0.05). Conclusion Negative pressure irrigation and PUI promoted better cleaning of main and simulated lateral canals. Clinical significance Conventional manual irrigation technique may promote less root canal cleaning in the apical third. For this reason, the search for other irrigation protocols is important, and EndoVac and PUI are alternatives to contribute to irrigation effectiveness. How to cite this article Tanomaru-Filho M, Miano LM, Chávez-Andrade GM, Torres FFE, de Toledo RL, Guerreir-Tanomaru JM. Cleaning of Root Canal System by Different Irrigation Methods. J Contemp Dent Pract 2015;16(11):859-863.
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Levvey, Bronwyn. "Reflections on Australian DCD lung donation and transplant journey Report from the 38th Annual Meeting — International Society for Heart and Lung Transplantation, Nice, France: 11–14 April 2018". Transplant Journal of Australasia 28, Number 1 (30.04.2019): 15–19. http://dx.doi.org/10.33235/tja.28.1.15-19.
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‘10 Years On: The Significant Impact of Controlled DCD Lung Donors on Lung Transplant Opportunities and Outcomes’ Purpose Since 2006, the Alfred Hospital has increasingly utilised controlled DCD donor lungs to optimise LTx opportunities and reduced waiting list (WL) deaths. This study evaluated the impact of DCD donation on LTx WL time and mortality, and compared post-LTx outcomes of DCD and contemporaneous DBD LTx performed over the first 10 years. Method This was a retrospective analysis of all LTx done at our institution between May 2006 and February 2017 (n=696, 150 DCD LTx, 546 DBD LTx) was undertaken. WL time/mortality, donor and recipient demographics, early outcome measures, survival and cause of death were compared. Our institution regularly utilises extended DCD and DBD donor lungs; however, it does not yet routinely utilise ex-vivo lung perfusion (EVLP) to evaluate these extended donor lungs, unlike many programs in the USA and Europe. Results The use of DCD donors has resulted in 25% more LTx annually, reduced overall WL times (245 to 135 days, p<0.001) and WL mortality (29% to 5%, p<0.01) from 2006 to 2017 respectively. Compared to DBD, DCD donors were intubated in ICU Longer (115 vs 79hrs, p<0.01), were older (45 vs 41 yrs, p<0.01) and were less commonly distant (>300 km) donors (20% vs 35%, p<0.01). DCD recipients compared to DBD had a reduced WL time (101 vs 120 days, p=0.03) and longer graft ischaemic time (323 vs 287 mins, p<0.01). There was no difference in intensive care unit (ICU) or hospital length of stay between DCD and DBD; and importantly, no significant difference in 1, 5 or 10 year survival rates comparing DCD vs DBD (96%, 69% and 53% vs 92%, 64% and 51% respectively, p=ns). Conclusions Controlled DCD donation has significantly and safely increased overall LTx numbers, without reducing DBD LTx (Figure 1), and has also reduced WL time and mortality with excellent 1, 5 and 10 year LTx survival for both DCD and DBD LTx compared to ISHLT at our institution (Figure 2). Importantly, our results also show that EVLP is not required for a successful utilisation of DCD donor lungs for LTx.
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O'Donoghue, Niamh, Shiva Shrotriya, Aynur Aktas, Barbara Hullihen, Serkan Ayvaz i Declan Walsh. "Weight changes at diagnosis in solid tumours." Journal of Clinical Oncology 35, nr 15_suppl (20.05.2017): e21655-e21655. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.e21655.
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e21655 Background: Unintentional weight loss is common in cancer and associated with increased morbidity and mortality. Most research to date has examined weight loss in advanced disease. The clinical significance of any weight change (WC) (loss/gain) before/at cancer diagnosis remains unclear. This study aimed to determine the prevalence and clinical significance of WC at diagnosis in out-patients with solid tumours presenting to a tertiary academic medical centre. Methods: A retrospective study of the electronic medical record (EMR) was conducted (n=6477). Those with a pre-diagnosis weight, T0, (recorded within 6 months of cancer diagnosis) and 2 subsequent weights (diagnosis, T1; final visit, T2) were identified (n=4258). Logistic regression and survival analysis identified WC predictors and overall survival respectively. The significance threshold was p < 0.05. Results: Mean age was 61 ±12.5 years. 54% (n=2315) were male. Common tumour sites were breast (17%; n=725), prostate (16%; n=664), lung (14%; n=599) and upper GI (11%; n=470). Known metastatic disease present at T1=15% (n=652). 68% (n=2908) were overweight or obese (WHO BMI Classification) at T1. 98% (n=4159) had WC from T0-T1(loss: 58%; n=2454; gain: 40%; n=1705). Primary tumour sites significantly associated with weight loss (WL) included colon, head & neck, kidney, lung and upper GI. 8% (n=320) were cachectic (>5% WL in previous 6 months) and 50% (n=2134) were pre-cachectic (≤ 5% WL) at T1; 3% had “Abnormal Weight Loss” (ICD 9 Code). Survival was worst with WL >5% and weight gain (WG) ≥ 10% from T0-T1 (p<0.05). However, those with 2.5-5% WL from T0-T1 were also at risk (p<0.05); 0.1-2.4% WG was protective. Primary tumour site (lung, upper GI) and normal/underweight BMI at T1 predicted poor prognosis. Conclusions: Weight changes were highly prevalent, but WL typically was undiagnosed. Most were overweight or obese at diagnosis. Nevertheless 58% (n=2454) of those reviewed at T1 met current criteria for cachexia or pre-cachexia. Those with WL > 5% or WG ≥ 10% had worst survival. The majority had evidence of significant, yet frequently undiagnosed, WC abnormalities at diagnosis.
Książki na temat "Wl 340.2"
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The central nervous system: Structureand function. Wyd. 2. New York: Oxford University Press, 1998.
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The central nervous system: Structure and function. Wyd. 3. New York: Oxford University Press, 2003.
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The central nervous system: Structure and function. New York: Oxford University Press, 1992.
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