Artykuły w czasopismach na temat „Weekly rest”
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PEKŞEN, Miraç Şamil. "Weekly Rest in Part-Time Employment Contracts". Türkiye Adalet Akademisi Dergisi, nr 54 (3.04.2023): 339–68. http://dx.doi.org/10.54049/taad.1274447.
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Hafta tatili dinlenme hakkı kapsamında yer alan önemli bir haktır. Hafta tatilinde işçiler bir yandan dinlenirken bir yandan da çalışmadıkları halde ücrete hak kazanırlar. Kısmi süreli iş sözleşmesiyle çalışanların böylesine önemli bir haktan yararlanıp yararlanamayacakları tartışma konusudur. Zira hafta tatiline ilişkin yasal düzenlemeler tam süreli iş sözleşmesiyle çalışanlar dikkate alınarak hazırlanmıştır. Bunun neticesinde kısmi süreli iş sözleşmesiyle çalışanların hafta tatiline hak kazanıp kazanamayacakları belirsiz hale gelmiştir. Öğretide konuya ilişkin farklı görüşler ileri sürülmüştür. Ayrıca konuya ilişkin yargı kararları da çeşitlilik göstermektedir. Yargıtay yakın zamana kadar kısmi süreli iş sözleşmesiyle çalışanların hafta tatiline hak kazanamayacakları görüşündeydi. Yeni tarihli kararlar ise kısmi süreli iş sözleşmesiyle çalışanların hafta tatiline hak kazanabilecekleri yönündedir. Çalışmada kısmi süreli iş sözleşmesiyle çalışanların hafta tatili hakkı karşısındaki durumları incelenecektir. Bunun için öncelikle hafta tatili ve kısmi süreli iş sözleşmesi hakkında genel bilgiler verilecektir. Ardından hafta tatiline hak kazanma koşulu incelenecektir. Son aşamada ise kısmi süreli iş sözleşmesiyle çalışanların hafta tatiline hak kazanma koşulunu sağlayıp sağlamadıkları üzerinde durulacaktır.
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Liberal Fernandes, Francisco. "O fim do descanso semanal obrigatório ao sétimo dia?" Revista Electrónica de Direito 23, nr 3 (październik 2020): 42–63. http://dx.doi.org/10.24840/2182-9845_2020-0003_0004.
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The monologue that is reproduced has in its genesis two sentences related to the imperfect problem of the enjoyment of weekly rest at shift work: the judgments of the Court of Justice of the European Union, of 9-11-2017 (Maio Marques da Rosa, case C - 306/16), and the Supreme Court of Justice, of 14-11-2018 (case 1181/15.4T8MTS.P1.S1). The fact that the issue in question was decided on the basis of rules of general scope (respectively, Article 5, first part, of the Directive 2003/88, concerning certain aspects of the organisation of working time, and Article 232, paragraph 1, of the Labour Code) has given to give these decisions an innovative dimension, potentially disruptive in the social and legal sphere, if it is under-stood that the normativity of the first sentence is directly extendable to the com-mon of labour contracts. The final conclusion is that the Portuguese labour system enshrines the weekly rest rule on the seventh day, allowing for the possibility of derogations for a limited set of activities; however, in relation to these, the application of this regime depends on provision in terms of collective labour regulation instruments.
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Ertürk, Olgu Özdemir. "Non-dissolution of the Daily Rest Period into the Weekly Rest Period". International Labor Rights Case Law 9, nr 3 (3.11.2023): 389–93. http://dx.doi.org/10.1163/24056901-09030020.
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Poliak, Miloš, Patrícia Šimurková, Marek Jaśkiewicz, P. Posuniak i J. Stokłosa. "The Impact of the Ban on Spending Weekly Rest in the Vehicle on Transport Planning in the EU". New Trends in Production Engineering 1, nr 1 (1.10.2018): 27–33. http://dx.doi.org/10.2478/ntpe-2018-0003.
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Abstract The working conditions of truck drivers and social legislation are both topical and political issues in the field of road freight transport. The contribution outlines problems which are linked to the observance of the ban on weekly rest in the vehicle. Based on the judgment, the Court of Justice of the European Union explicitly forbids drivers to take their regular weekly rest in the vehicle. The contribution identifies the impact of the ban on spending weekly rest in the vehicle on transport planning in the EU. The aim of the contribution is also to highlight the existing problems in international road freight transport sector in connection with insufficient number of truck parks with accommodation.
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Kang, Seong-Tae. "Amendment of Weekly Rest Systems under the Labor Standards Act". Korean Journal of Law and Society 54 (30.04.2017): 211–39. http://dx.doi.org/10.33446/kjls.54.7.
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Gil, Leszek, Daniel Pieniak i Agata Walczak. "Safety in road transport". Scientific Journal of the Military University of Land Forces 189, nr 3 (30.09.2018): 36–42. http://dx.doi.org/10.5604/01.3001.0012.6225.
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The article describes the transport process and the drivers’ approach with regard to respecting the applicable driver's working time standards. This paper presents and discusses the results of a survey conducted among professional drivers, the primary purpose of which was to obtain the response to the question whether drivers actually rest during the break. Legal regulations strictly determine the minimum daily and weekly rest periods and the maximum daily and weekly driving times. Appropriate advanced technologies represented by measuring tools to the great extent oblige drivers to take a rest at the right time. Nevertheless, on the basis of the research it was stated that drivers frequently execute other activities, thus trying to increase their profits during break time, and therefore they commit for a rest shorter time than this resulting from the current working time regulations. The introduction of newer and more advanced solutions in the recording equipment substantially limits the possibility of performing other activities related to the vehicle during a break, and forces drivers to have a rest, thereby they pose less risk on the roads.
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Rutkowska, Beata. "Scope of Reference of Employees’ Right to Daily and Weekly Rest (A Discussion Article)". Studia z zakresu Prawa Pracy i Polityki Społecznej 29, nr 2 (21.07.2022): 201–12. http://dx.doi.org/10.4467/25444654spp.22.017.15691.
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The paper attempts to answer the question of whether periods of daily and weekly rest provided for in Art. 132 and 133 of the Labour Code Act of 26 June 1974 are to be accounted for with reference to the employment relationship, employer, or employee. Determinations in this respect were made by analysing various situations occurring in practice—employment of an employee with one employer on the basis of one employment relationship, simultaneous employment of an employee in several employment relationships with that employer, and parallel employment of an employee by more than one employer. This takes into account the need to ensure that the employee is afforded rest periods within strictly defined legal limits, as well as the nature of the right to daily and weekly rest and the purposes of this right.
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Cerame, A., P. Coucheiro, L. Cayuela, M. Maiques i A. Franco Soler. "Descriptive study on the working conditions of residents of psychiatry in Madrid: working hours and 24-hour on call shifts". European Psychiatry 65, S1 (czerwiec 2022): S102. http://dx.doi.org/10.1192/j.eurpsy.2022.291.
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Introduction Resident physician’s working conditions are linked to poor health outcomes of professionals and patient’s safety. Previous studies suggest that residents in Spain have difficulties enjoying mandatory rest after on-call shifts. Objectives This study aims at describing the working conditions: working hours and the absence of mandatory rest periods after a 24h on-call shift in residents of psychiatry in the region of Madrid. Methods A descriptive observational cross-sectional study was carried out through an anonymous survey adapted from the available literature. Results Up to 24,1% of the surveyed residents could not enjoy mandatory resting periods after a 24 hour on-call shift and the mandatory weekly rest of at least 36 hours was not done in up to 17% of the cases with statistical significance (p <0.05). The average number of 24 hours on call shifts residents had to work per month was 5, which exceeds the maximum weekly hours allowed by law. Conclusions The findings reveal a violation of resident physician labor rights in relation to resting times after on-call shifts, weekly breaks and working hours. These phenomena pose a significant threat to resident physician’s health and patient safety. Disclosure No significant relationships.
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Bălăneasa, Maria-Cristina. "Aspects Regarding Annual Leave and Weekly Rest-Basic Rights of Employees in Romania". European Journal of Law and Public Administration 9, nr 2 (20.12.2022): 115–24. http://dx.doi.org/10.18662/eljpa/9.2/188.
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This material proposes the description of some general aspects regarding the employees' right to vacation, but also regarding their weekly rest as the main forms of rest and aimed at restoring physical and intellectual strength. Employers have legal obligations in granting them and in case of non-compliance, the sanctioning force of the state intervenes through the control actions of the Labor Inspectorate. Data on the number of checks and sanctions applied are reproduced in the pages of this work in order to highlight the degree of compliance with labor legislation by employers.
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Maloni, Judith A., Greg R. Alexander, Mark D. Schluchter, Dinesh M. Shah i Seunghee Park. "Antepartum Bed Rest: Maternal Weight Change and Infant Birth Weight". Biological Research For Nursing 5, nr 3 (styczeń 2004): 177–86. http://dx.doi.org/10.1177/1099800403260307.
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Despite lack of evidence for effectiveness, obstetricians in the United States prescribe antepartum bed rest for more than 700,000 women per year. However, in nonpregnant samples, bed rest treatment produces weight loss. This study assessed maternal weight change (gain) during antepartum hospitalization for bed rest treatment; compared appropriateness of infant birth weights for gestational age, race, and gender; and determined whether maternal weight change predicted infant birth weight. The convenience sample for this longitudinal study consisted of 141 women with high-risk pregnancies who were treated with hospital bed rest. Weekly rate of pregnancy weight change by body mass index was compared with Institute of Medicine recommendations for rate of pregnancy weight gain. Infant birth weight was compared with current US infant birth weights for matching gestational age, gender, and race. Weekly antepartum weight change was significantly lower than Institute of Medicine recommendations (P < 0.001). Infant birth weights were also significantly lower than the national mean when matched for each infant’s gestational age, race, and gender ( P < 0.001). Maternal weight change predicted infant birth weight ( P = 0.05). Bed rest treatment is ineffective for improving pregnancy weight gain. Lower infant birth weights across all gestational ages suggest that maternal weight loss during bed rest may be associated with an increased risk of fetal growth restriction. A randomized trial comparing women with high-risk pregnancies who are ambulatory with those on bed rest is needed to determine whether bed rest treatment, underlying maternal-fetal disease, or both influence inadequate maternal weight gain and poor intrauterine growth.
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Garland, McKenna M., Raminta Wilson, Wesley K. Thompson, Murray B. Stein, Martin P. Paulus, Justin S. Feinstein i Sahib S. Khalsa. "A randomized controlled safety and feasibility trial of floatation-REST in anxious and depressed individuals". PLOS ONE 19, nr 6 (6.06.2024): e0286899. http://dx.doi.org/10.1371/journal.pone.0286899.
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Background Reduced Environmental Stimulation Therapy via floatation (floatation-REST) is a behavioral intervention designed to attenuate exteroceptive sensory input to the nervous system. Prior studies in anxious and depressed individuals demonstrated that single sessions of floatation-REST are safe, well-tolerated, and associated with an acute anxiolytic and antidepressant effect that persists for over 48 hours. However, the feasibility of using floatation-REST as a repeated intervention in anxious and depressed populations has not been well-investigated. Methods In this single-blind safety and feasibility trial, 75 individuals with anxiety and depression were randomized to complete six sessions of floatation-REST in different formats: pool-REST (weekly 1-hour float sessions), pool-REST preferred (float sessions with flexibility of duration and frequency), or an active comparator (chair-REST; weekly 1-hour sessions in a Zero Gravity chair). Feasibility (primary outcome) was assessed via an 80% rate of adherence to the assigned intervention; tolerability via study dropout and duration/frequency of REST utilization; and safety via incidence of adverse events and ratings about the effects of REST. Results Of 1,715 individuals initially screened, 75 participants were ultimately randomized. Six-session adherence was 85% for pool-REST (mean, M = 5.1 sessions; standard deviation, SD = 1.8), 89% for pool-REST preferred (M = 5.3 sessions; SD = 1.6), and 74% for chair-REST (M = 4.4 sessions; SD = 2.5). Dropout rates at the end of the intervention did not differ significantly between the treatment conditions. Mean session durations were 53.0 minutes (SD = 12.3) for pool-REST, 75.4 minutes (SD = 29.4) for pool-REST preferred, and 58.4 minutes (SD = 4.3) for chair-REST. There were no serious adverse events associated with any intervention. Positive experiences were endorsed more commonly than negative ones and were also rated at higher levels of intensity. Conclusions Six sessions of floatation-REST appear feasible, well-tolerated, and safe in anxious and depressed individuals. Floatation-REST induces positively-valenced experiences with few negative effects. Larger randomized controlled trials evaluating markers of clinical efficacy are warranted. Clinical Trial Registration Identifier NCT03899090.
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Gonçalves, Alberto F., i Matthew S. Kolehmainen. "Frequência de Exercícios e Níveis de Ansiedade e Estresse durante a Pandemia de COVID-19 são mediados pelo Anseio por Repouso e Gasto de Energia". Cadernos de Psicologia 3, nr 2 (2023): 01–12. http://dx.doi.org/10.9788/cp2023.2-06.
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The concept of craves to move and to rest is a psychological construct that has recently been proposed as a key predictor for exercise adherence and a more active lifestyle in the fi eld of motivation research. During the COVID-19 pandemic lockdown, we observed that individuals who engaged in regular exercise reported better levels of psychological health and wellbeing. Based on this observation, our hypothesis was that craves to move and to rest could also mediate the relationship between the frequency of physical exercise and anxiety and perceived stress. To test our hypothesis, we recruited 574 volunteers who completed four online questionnaires assessing state anxiety, perceived stress, craves to move and to rest, and sociodemographic information (including weekly frequency of exercise) during the COVID-19 lockdown. We used a structural equation model, specifi cally a mediation analysis, which revealed a signifi cant mediating eff ect of craves to move and to rest between the frequency of physical exercise and anxiety and perceived stress levels. In other words, the weekly frequency of exercise was not directly associated with state anxiety, but rather through its eff ect on craves to move and to rest. Our results suggest that understanding the role of craves to move and to rest is crucial in comprehending the relationship between physical exercise and anxiety.Keywords: Motivation, anxiety, stress, exercise, COVID-19
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Burger, Pauline. "Weekly 24-Hour Rest Period to be Provided within Each Seven-Day Period". International Labor Rights Case Law 4, nr 2-3 (9.02.2019): 242–45. http://dx.doi.org/10.1163/24056901-00402018.
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Cho, Yongman. "Comparative Legal Review of International Labor Standards and Korean Law on Weekly Rest". Journal of Labour Law 82 (30.06.2022): 195–235. http://dx.doi.org/10.69596/jll.2022.06.82.195.
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Kim, Tae Yong, Byeong IL Lee, Gyu IM Kim, Ju Young Kim, Jin Seok Ahn, Jiyoung Rhee, Sun Young Rha i in. "The efficacy and toxicity of 3-weekly TS-1 containing chemotherapy in patients with unresectable advanced gastric cancer." Journal of Clinical Oncology 30, nr 15_suppl (20.05.2012): e14580-e14580. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.e14580.
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e14580 Background: TS-1 has shown good efficacy against unresectable advanced gastric cancer (AGC). Conventionally TS-1 containing chemotherapy (CTx) is performed on 5-weekly or 6-weekly basis. We lack robust evidence for the efficacy and safety of 3-weekly TS-1 containing CTx. In Korea, 3-weekly TS-1 containing CTx can be used as off-label under permission of Health Insurance Review and Assessment service (HIRA). We and HIRA conducted this study to confirm the efficacy and tolerability of 3-weekly TS-1 containing CTx in unresectable AGC. Methods: We retrospectively analyzed patients with unresectable AGC who received 3-weekly TS-1 containing CTx between June 2007 and January 2011. In 3-weekly TS-1 monotherapy, TS-1 40-60mg depending on patient’s body surface area was administered orally twice a day for 14 days followed by a 1-week rest every 3 weeks. In 3-weekly TS-1/cisplatin combination CTx, TS-1 40mg/m2 was given orally twice a day for 14 days followed by 1-week rest and cisplatin 60 mg/m2 on day 1 was given by intravenous infusion every 3 weeks. Results: A total of 1372 patients (TS-1 monotherapy: 265 (19.3%), TS-1/cisplatin : 1107 (80.7%)) were enrolled from 31 institutions. Response rate of 3-weekly TS-1 monotherapy was 18.1%. Progression-free survival (PFS) and overall survival (OS) were 5.2 months (95% C.I., 4.5-5.9) and 14.3 months (95% C.I., 10.6-17.9), respectively. Response rate of 3-weekly TS-1/cisplatin was 29.4%. PFS and OS of 3-weekly TS-1/cisplatin were 6.8 months (95% C.I., 6.3-7.4) and 16.1 months (95% C.I., 14.4-17.9) respectively. Common toxicities of TS-1 monotherapy included nausea/vomiting (N/V) (13.6%), anemia (13.2%) and neutropenia (10.2%). However, the incidences of more grade 3/4 toxicities were less than 3.0%. All grades of neutropenia, N/V and anemia occurred in 35.4%, 21.1% and 13.3% of patients receiving 3-weekly TS-1/cisplatin. However, grade 3/4 toxicities including neutropenia, N/V and anemia occurred in only 17.8%, 3.0% and 2.9%. Conclusions: Three-weekly TS-1 monotherapy or TS-1/cisplatin CTx showed good efficacy and well tolerability. Our study suggests that 3-weekly scheduled regimens may be a good treatment option for unresectable AGC patients.
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Zhou, Li, Hongliang Feng, Bei Huang, Jing Wang, Shi Tang, Jihui Zhang, Joey Chan i in. "0683 Rest-activity Pattern in Isolated RBD – from Prodromal Stage to Association with Parkinsonism-first Phenoconversion". SLEEP 47, Supplement_1 (20.04.2024): A293. http://dx.doi.org/10.1093/sleep/zsae067.0683.
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Abstract Introduction Previous evidence suggested that the alteration of rest-activity pattern occurred in patients with isolated rapid eye movement behavior disorder (iRBD), a prodromal stage of α-synucleinopathy with implication to future phenoconversion. Nonetheless, it remains unclear whether this rest-activity pattern alteration has already emerged in the prodromal stage of RBD, and whether it would be related to conversion of iRBD into parkinsonism-first or dementia-first subtype of α-synucleinopathy. Methods We performed 1) a case-control study to compare the rest-activity pattern measured by 7-day actigraphy among prodromal RBD subjects (n = 21) and their age-, sex-, and body mass index-matched control subjects (n = 52) and patients with iRBD (n = 63); and 2) a longitudinally follow-up study to investigate the predictive value of altered rest-activity pattern to parkinsonism-first or dementia-first subtype of α-synucleinopathy in full sample of patients with iRBD (n = 170). Prodromal RBD subjects were defined as subjects who had recurrent dream-enactment behaviors but with subthreshold REM sleep electromyography activity. Generalized linear model was employed to assess rest-activity pattern in prodromal RBD subjects and competing risk regression model was used to determine the predictive value of rest-activity pattern to RBD phenoconversion. Results Similar to patients with iRBD, prodromal RBD subjects had more daytime probable napping (percentage and duration) and lower average weekly activity level and physical activity level during active period as compared to control subjects. Of 170 patients with iRBD, 166 were successfully followed up with a mean follow-up duration of 4.6 years. Lower average weekly activity level, amplitude, and physical activity level during active period were associated with a higher risk of parkinsonism-first subtype of α-synucleinopathy, instead of dementia-first subtype. Conclusion Our study found that altered rest-activity pattern has already emerged in prodromal stage of RBD. As for iRBD patients, lower physical activity level and amplitude might serve as predictive markers of parkinsonism-first conversion. Support (if any) No
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Schumann, Margaret Fenerty, i Anju Mary Paul. "The Giving Up of Weekly Rest-Days by Migrant Domestic Workers in Singapore: When Submission Is Both Resistance and Victimhood". Social Forces 98, nr 4 (26.06.2019): 1695–718. http://dx.doi.org/10.1093/sf/soz089.
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AbstractWhy do so few live-in migrant domestic workers (MDWs) in Singapore utilize their weekly rest-day entitlement? Using data drawn from 3,886 online profiles of prospective MDWs and 40 interview sessions with MDWs, employers, and manpower agencies, we demonstrate how the industry encourages a “logic of submission” around rest-days. Through processual analysis, we unearth multiple, repeated moments of capitulation at key moments in a MDW’s work-life: (1) their interactions with a recruitment agency while still in their home country; (2) their matching with an overseas employer; (3) the duration of their two-year contract; and (4) the time of contract renewal. Submission to less frequent rest-days can secure their employability and financial mobility but also further individuates the MDW within the employer’s household and may lead to the engraining of a habitus of submissiveness towards their employers that can open the door to workers’ exploitation. We demonstrate how nationality and work experience further inflect this logic of submission to motivate non-Filipina and inexperienced MDWs to request even fewer rest-days than their counterparts. By combining feminist migration scholarship on Asian MDWs, with a sociology of law analysis, we offer up an example of how the same act of submission can simultaneously embody both resistance and victimhood depending upon the temporal and spatial scale used, and varying interpretations of the rest-day benefit as a much-needed respite, a monetizable benefit, or a signaling mechanism.
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Thorpy, Michael, Akinyemi Ajayi, Bruce Corser, Clete Kushida, Maurice Ohayon, Richard Bogan i Jennifer Gudeman. "0646 Efficacy Outcomes Among Male and Female Participant Subgroups: A Post Hoc Analysis from REST-ON". SLEEP 47, Supplement_1 (20.04.2024): A276. http://dx.doi.org/10.1093/sleep/zsae067.0646.
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Abstract Introduction Once-nightly sodium oxybate (ON-SXB; LUMRYZ™) is an effective and safe treatment for excessive daytime sleepiness (EDS) and cataplexy in adults with narcolepsy. This post hoc analysis assessed efficacy in female and male participant subgroups from the phase 3 REST-ON trial. Methods REST-ON (NCT02720744) participants (≥16 years) with narcolepsy type 1 (NT1) or NT2 were randomized (1:1) to receive ON-SXB at 4.5 g (week 1), 6 g (weeks 2–3), 7.5 g (weeks 4–8), and 9 g (weeks 9–13) or placebo. Data shown are least squares mean changes from baseline (SE) in mean sleep latency on the Maintenance of Wakefulness Test (MWT) and weekly number of cataplexy episodes (NCA; NT1 only) calculated at week 13 (9 g) in the modified intent-to-treat (mITT) population (ie, randomized participants with ≥1 efficacy measurement post 6-g dose). Results The mITT population included more female (ON-SXB, n=60; placebo, n=65) than male (ON-SXB, n=37; placebo, n=28) participants. Baseline mean sleep latency (SD) on the MWT (min) was 5.24 (3.41) and 4.59 (2.65) for female and male participants in the ON-SXB arm, respectively. At week 13, improvements on the MWT with ON-SXB were greater for female than for male participants (11.62 [1.39], 9.52 [1.26]). Baseline mean weekly NCA (SD) was 19.63 (9.0) and 17.48 (8.03) for female and male participants, respectively, in the ON-SXB arm. Improvements in weekly NCA with ON-SXB were similar for female and male participants at week 13 (–11.80 [1.23], –11.31 [1.62]). Conclusion These post-hoc subgroup data demonstrate improvement with ON-SXB in EDS and in cataplexy for people with narcolepsy regardless of gender. Support (if any) Avadel Pharmaceuticals
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Itani, Osamu, Yoshitaka Kaneita, Maki Ikeda, Shuji Kondo, Atsushi Murata i Takashi Ohida. "Associations of Work Hours and Actual Availability of Weekly Rest Days with Cardiovascular Risk Factors". Journal of Occupational Health 55, nr 1 (styczeń 2013): 11–20. http://dx.doi.org/10.1539/joh.12-0034-oa.
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Sharpe, Lisa, i Maria K. Conron. "Making the Most of Bed Rest: Weekly Support Group and Education for Hospitalized Antepartum Patients". Journal of Obstetric, Gynecologic & Neonatal Nursing 43 (czerwiec 2014): S10. http://dx.doi.org/10.1111/1552-6909.12374.
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Casino, Gonzalo, Roser Rius i Erik Cobo. "National citation patterns ofNEJM,The Lancet,JAMAandThe BMJin the lay press: a quantitative content analysis". BMJ Open 7, nr 11 (listopad 2017): e018705. http://dx.doi.org/10.1136/bmjopen-2017-018705.
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ObjectivesTo analyse the total number of newspaper articles citing the four leading general medical journals and to describe national citation patterns.DesignQuantitative content analysis.Setting/sampleFull text of 22 general newspapers in 14 countries over the period 2008–2015, collected from LexisNexis. The 14 countries have been categorised into four regions: the USA, the UK, Western World (European countries other than the UK, and Australia, New Zealand and Canada) and Rest of the World (other countries).Main outcome measurePress citations of four medical journals (two American:NEJMandJAMA; and two British:The LancetandThe BMJ) in 22 newspapers.ResultsBritish and American newspapers cited some of the four analysed medical journals about three times a week in 2008–2015 (weekly mean 3.2 and 2.7 citations, respectively); the newspapers from other Western countries did so about once a week (weekly mean 1.1), and those from the Rest of the World cited them about once a month (monthly mean 1.1). The New York Times cited above all other newspapers (weekly mean 4.7). The analysis showed the existence of three national citation patterns in the daily press: American newspapers cited mostly American journals (70.0% of citations), British newspapers cited mostly British journals (86.5%) and the rest of the analysed press cited more British journals than American ones.The Lancetwas the most cited journal in the press of almost all Western countries outside the USA and the UK. Multivariate correspondence analysis confirmed the national patterns and showed that over 85% of the citation data variability is retained in just one single new variable: the national dimension.ConclusionBritish and American newspapers are the ones that cite the four analysed medical journals more often, showing a domestic preference for their respective national journals; non-British and non-American newspapers show a common international citation pattern.
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Cutting, J. G. M., D. K. Strydom, G. Jacobs, D. U. Bellstedt, K. J. Van Der Merwe i E. W. Weiler. "Changes in Xylem Constituents in Response to Rest-breaking Agents Applied to Apple before Budbreak". Journal of the American Society for Horticultural Science 116, nr 4 (lipiec 1991): 680–83. http://dx.doi.org/10.21273/jashs.116.4.680.
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Xylem sap was vacuum-extracted weekly from 1-year-old apple shoots from trees treated with dinitro-o-cresol (DNOC) oil, hydrogen cyanamide, or untreated controls. Sampling began 1 week before treatment and continued until 2 weeks after budbreak had occurred in the control trees. Sorbitol, calcium, magnesium, potassium, and zeatin-type cytokinin concentrations were determined by enzymatic, atomic absorption, and immunoassay methods, respectively. The rest-breaking treatments resulted in earlier and more intense budbreak. Xylem sap cytokinin concentrations increased rapidly in response to the rest-breaking chemicals and peaked just before or at budbreak. The rapid increase in cytokinin was closely followed by increases in calcium and magnesium concentrations in the sap. Potassium concentration appeared to be unaffected by rest-breaking treatment. Sorbitol levels dropped rapidly as a result of the rest-breaking treatments and appeared to be used rapidly in budbreak and early bud growth.
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Barwaśny, Mateusz. "Right to Rest of the Self-Employed under International and EU Law". Acta Universitatis Lodziensis. Folia Iuridica 101 (29.12.2022): 183–91. http://dx.doi.org/10.18778/0208-6069.101.13.
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The main objective of the foregoing article will be to determine whether a self-employed person has the right to rest under international and EU law. According to the research conducted by the OECD, in 2021, the self-employment rate for all countries reached 16.5% of all employed persons. Therefore, bearing in mind that self-employed persons constitute such a large group of all people who provide paid work, it is justified to consider whether they may be entitled to the appropriate protective guarantees, also in the area of the right to rest. Appropriate rest includes not only the right to a holiday, but also a period of daily and weekly rest and the limitation of the maximum working time. The right to rest is also very important in terms of work efficiency and safety in the workplace. Therefore, efforts should be made to ensure that every contractor, including the self-employed, has the right to a proper rest in order to regenerate his strength and exercise the right to health and safety, which every person is entitled to according to international legal regulations.
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Bae, Jihong, Sun Jin Sym, Joo-Hwan Park, Young Saing Kim, Hee Kyung Ahn, EUN KYUNG CHO, Dong Bok Shin, Ji-Hyeon Park, Jun-Young Yang i Woon-Kee Lee. "Evaluation of the efficacy and safety of a 3-weekly TS-1 regimen as adjuvant therapy for stage II and III advanced gastric cancer: A pilot study." Journal of Clinical Oncology 42, nr 3_suppl (20.01.2024): 350. http://dx.doi.org/10.1200/jco.2024.42.3_suppl.350.
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350 Background: Adjuvant therapy for stage II and III advanced gastric cancer (AGC) is essential in improving patient outcomes. The standard therapy, TS-1 at 80 mg/m2/day for 4 weeks with a 2-week rest, is recommended for 1 year or 8 courses. This study investigates the efficacy and safety of a 3-weekly adjuvant TS-1 regimen in AGC patients. Methods: We conducted an analysis of 93 patients who underwent gastrectomy with D2 lymphadenectomy and initiated a 3-weekly adjuvant TS-1 regimen between February 2017 and May 2022. The novel regimen consisted of TS-1 at 80 mg/m2/day for 2 weeks, followed by a 1-week rest, with a treatment goal of 1 year or 16 courses. Results: Among the 93 patients, 12 (13%) experienced disease recurrence during a median follow-up of 24.6 months (range: 4.2 to 63.3 months). Of the Stage II patients (n=73), 7 cases (9.5%) had recurrent disease, while 5 cases (25%) in the Stage III group (n=20) experienced recurrence. Recurrence-Free Survival (RFS) rates at 1 year, 3 years, and 5 years were 92.0% (95%CI 86.5 to 97.9), 84.7% (95%CI,76.4% to 93.9%), and 78.6% (95%CI, 65.8% to 94.0%), respectively. A total of 80 patients (86%) completed the adjuvant 3-weekly TS-1 treatment for 1 year or 16 courses, while 25 patients (26.9%) completed the treatment with dose reductions. Adverse events, primarily Grade 1 or 2 diarrhea (28%) and nausea (20%), were manageable. Conclusions: The novel 3-weekly TS-1 regimen as adjuvant therapy exhibited favorable efficacy and tolerable toxicity in AGC patients. These findings suggest the need for further investigation of this regimen in future clinical studies.
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Koenker, Diane P. "Whose Right to Rest? Contesting the Family Vacation in the Postwar Soviet Union". Comparative Studies in Society and History 51, nr 2 (20.03.2009): 401–25. http://dx.doi.org/10.1017/s0010417509000176.
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The idea of leisure and vacations in the Soviet Union at first glance suggests a paradox. As a system based on the labor theory of value, the USSR emphasized production as the foundation of wealth, personal worth, and the path to a society of abundance for all. Work—physical or mental—was the obligation of all citizens. But work took its toll on the human organism, and along with creating the necessary incentives and conditions for productive labor a socialist system would also include reproductive rest as an integral element of its economy. The eight-hour work day, a weekly day off from work, and an annual vacation constituted the triad of restorative and healthful rest opportunities in the emerging Soviet system of the 1920s and 1930s.
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Gnap, Jozef, Vladimír Konečný, Radovan Slávik i Dominika Beňová. "Possible Impacts of Regulating the Weekly Rest of Road Freight Drivers on Logistics in EU Countries". Naše more 65, nr 4 (październik 2018): 259–65. http://dx.doi.org/10.17818/nm/2018/4si.18.
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Andersson, O. K., T. Hedner i G. Nyberg. "Antihypertensive and metabolic effects of bopindolol at rest and during exercise – is once weekly dosage possible?" Current Opinion in Cardiology 3 (styczeń 1988): S73—S80. http://dx.doi.org/10.1097/00001573-198801002-00012.
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Wang, Yadan, Yu Hu, Lisha Ai, Bhuveshwarnath Gowrea, Guohui Cui, Jun Fang, Chunyan Sun i Lu Zhang. "Once Weekly Bortezomib Plus Dexamethasone in Newly Diagnosed Multiple Myeloma: A Preliminary Study in Chinese Patients". Blood 118, nr 21 (18.11.2011): 5128. http://dx.doi.org/10.1182/blood.v118.21.5128.5128.
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Abstract Abstract 5128 Introduction: Bortezomib has become a cornerstone in the management of multiple myeloma (MM) and the currently accepted practice is a twice weekly administration at 1.3mg/m2. Recently, several studies have demonstrated a successful treatment with the modified Bortezomib schedule in refractory or elderly newly diagnosed MM. These previous studies suggest that, given at weekly intervals, Bortezomib remains equally efficacious and may even improve tolerability. We here present our institution's experience where we retrospectively compare the efficacy and toxicity parameters between once weekly (1.6mg/m2) and twice weekly (1.3mg/m2) schedule of Bortezomib plus Dexamethasone in newly diagnosed, untreated MM patients. Methods: The once weekly schedule consisted of 5-week cycle of which Bortezomib plus Dexamethsone was administered during the first 4 weeks as follows: Bortezomib 1.6mg/m2 intravenously on days 1, 8, 15, 22 and Dexamethsone 20mg intravenously on days 1–2, 8–9, 15–16 and 22–23 followed by a 12-day rest period. The twice weekly schedule consisted of 3-week cycle as follows: Bortezomib 1.3mg/m2 intravenously on days 1, 4, 8, 11 and Dexamethsone 20mg intravenously on days 1–2, 4–5, 8–9 and 11–12 followed by a 9-day rest period. We retrospectively collected data from Jan 2009 to Dec 2010 of 37 patients with newly diagnosed MM who were either treated with once weekly schedule (n =13) or twice weekly schedule (n = 24). Allocation of patients to their respective treatment group was not randomized but rather on the basis of their means, after they were made fully aware that the once weekly schedule was still under evaluation. Results: The median age was similar between two schedules (53 years vs. 54.5 years, P=0.674). Both treatment groups received a median number of two cycles of chemotherapy. The median follow-up was also similar, being 12 months (range, 4–19) in the once weekly treatment group and 10.5 months (range, 2–19)in the twice weekly treatment group. In the standard twice weekly schedule, the overall response rate of 74.9% including 2(8.3%) CR, 8(33.3%) VGPR and 8(33.3%) PR, while 2(8.3%) patients had stable disease (SD) and 3(12.5%) had progressive disease (PD). Among the patients in the weekly schedule, 10 of 13 patients (77.0%) achieved at least PR with 30.8% at least VGPR. In addition, SD was observed in 1 patient (7.7%) and PD in another 1 patient (7.7%). The responses to treatment were not found to be statistically significant different in our study when comparing the once weekly schedule to the twice weekly schedule. The median time to the best response was 2 cycles (range,2–4) in the once weekly schedule as compared with 2.5 cycles (range,2–4) in the twice weekly schedule (P=0.564). The median survival was not reached in either schedule since the follow-up was not long enough. The median progression free survival (PFS) and duration of response (DOR) of the weekly schedule did not differ significantly from that of the twice weekly schedule (8 months vs. 10 months, P=0.545 and 6 months vs. 7 months, P=0.467; respectively). After a median follow-up of 12 months (range, 2–19), 2 patients (15.4%) in the weekly schedule and 4 patients (16.6%) in the twice weekly schedule had died (P=0.723) thus mortality in the two groups did not differ significantly. Over grade 3 of gastrointestinal symptoms were similar in the once weekly (16%) and twice weekly (20.5%) schedules. Peripheral sensory neuropathy was reported more frequently in the twice weekly schedule, including grade 1 in 4 patients (17%), grade 2 in 4 patients (17%), grade 3 in 3 patients (12.5%), and grade 4 in 1 patient (4%). While grade 1 neuropathy in 2 patients (15%), grade 2 in 1 patient (8%), grade 3 in 1 patient (8%) were reported in the weekly schedule and all had resolved within two months. All grade 3 and 4 hematologic toxic effects were more frequent in the twice- weekly schedule than in the weekly schedule (75% vs. 54%), as was over grade 2 of herpes zoster (16.5% vs. 8%). Incidence of over grade 2 rash remained low and was similar in the two schedules (both 8%). However the difference between the two schedules was not statistical significantly. Conclusions: Our study provides additional evidence that the once weekly Bortezomib (1.6mg/m2) plus Dexamethasone schedule is active and well tolerated in the treatment of patients with newly-diagnosed multiple myeloma, with the similar efficacy and lesser toxicity compared with the twice weekly schedule. Disclosures: No relevant conflicts of interest to declare.
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Guanghong, Li, i Zhang Yulin. "The evolutionary characteristics of the network attention of the five tourism performing arts products on the time scale". E3S Web of Conferences 292 (2021): 03017. http://dx.doi.org/10.1051/e3sconf/202129203017.
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Network attention is the intuitive expression of tourism demand and behavior habits on the Internet, with the help of Baidu Index platform to obtain the online attention of the five major tourism performing arts products from 2015 to 2019, and use quantitative methods to analyze their annual, monthly and weekly changes. The results are as follows, from the perspective of interannual change, the network attention of “Ancient Love of Song City” and “Amazing Xiangxi” shows an upward trend, while the rest of the impression series products show negative growth; from the perspective of monthly change, the network attention of “Impression Liu Sanjie", “Ancient Love of Song City” and “Impression West Lake” has seasonal characteristics; the overall change trend is mainly affected by the National Day holiday and summer vacation, the curve trend of “Impression Lijiang” and “Amazing Xiangxi” is relatively stable; from the weekly change, the weekly change of tourism performing arts products is very small.
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Hoque, Ehteshamul, Shanaz Karim i Rakib Uddin Ahmed. "Weekly docetaxel in patients with metastatic breast cancer: A Bangladeshi perspective." Journal of Clinical Oncology 30, nr 15_suppl (20.05.2012): e11533-e11533. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.e11533.
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e11533 Background: Docetaxel has demonstrated high antitumor activity in first and second line treatment of metastatic breast cancer. Usually it is administrated three weekly at a dose of 75mg/ m2. We evaluated the efficacy and toxicity of Docetaxel in metastatic breast cancer in weekly bases. This study analyzed the efficacy and toxicity of docetaxel given weekly. Methods: Thirty eight patients with metastatic breast cancer received docetaxel, 35 mg/m2 weekly for six weeks, followed by two weeks interval. Additional cycles (three weeks' treatment, two weeks' rest) were given until disease progression or death. All patients had received prior chemotherapy. Of them 32 patients previously received anthracycline-containing regimens and 5 patients had received taxane based regimens. Results: Out of thirty eight patients thirty seven were evaluable. There was one complete response (3%), 11 patient has partial responses (30%), 17 patients with stable disease (46%) and six with disease progression (16%). Overall response rate was 78%. Median progression-free survival was 9.2 months. Three patients showed grade 3 neutropenia. 14 showed grade 3 alopecia, and various grade 1–2 non-haematological toxicities were observed. Treatment was delayed in two patients due to haemalotoxicity and stopped in one patient due to painful nail toxicity. Conclusions: Docetaxel is effective in three weekly regimens. In our study we found weekly docetaxel is as effective as the previous regimen. The efficacy of weekly docetaxel (35 mg/m2) can be an effective schedule for metastatic breast cancer who has received chemotherapy previously. The toxicity in this regimen is very low and manageable.
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Maloni, Judith A., Seunghee Park Margevicius i Elizabeth G. Damato. "Multiple Gestation: Side Effects of Antepartum Bed Rest". Biological Research For Nursing 8, nr 2 (październik 2006): 115–28. http://dx.doi.org/10.1177/1099800406291455.
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The birth rate for higher order multiples has dramatically increased in recent decades. Multiple gestation pregnancies are considered to be at high obstetric risk. Antepartum bed rest is often prescribed to offset complications despite the lack of evidence for its effectiveness in preventing complications. This longitudinal repeated-measures study identified side effects of antepartum bed rest treatment for 31 hospitalized women with twin or triplet gestation. Maternal weight gain and infant birth weight were recorded. Antepartum stressors were measured by the Antepartum Stressors Hospital Inventory, and depressive symptoms were measured by the Center for Epidemiologic Studies Depression Scale (CES-D). Antepartum and post-partum side effects of bed rest were also assessed by the Antepartum and Postpartum Symptom Checklists. The weekly rate of maternal weight gain during hospitalization was significantly less than recent recommendations for multiple gestation weight gain (t =– 2.14,p = .04). Infant birth weights were appropriate for gestational age. There were fewer than expected small-for-gestational-age infants. Concerns regarding family status and separation from family were the major antepartum stressors. Women reported a high number of symptoms during bed rest (M= 22), which did not significantly change across 2 weeks. CES-D scores for depressive symptoms were high on antepartum hospital admission. Postpartum symptoms were initially high but had significantly declined by 6 weeks: F(1, 27)= 15.68, p = .00. These findings suggest that interventions are needed to reduce antepartum maternal weight loss, stress, physiologic and psychosocial symptoms, and depressive symptoms, as well as reduce postpartum symptoms of maternal morbidity.
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Rybak, O. O. "FORMS OF REALIZATION OF THE RIGHT TO REST: UKRAINIAN REALITIES AND FOREIGN EXPERIENCE". Знання європейського права, nr 3 (2.02.2021): 50–54. http://dx.doi.org/10.32837/chern.v0i3.97.
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The article is devoted to the study of forms of realization of the right to rest in Ukraine and foreign countries. The opinions of modern scientists on the concept of realization of rights are considered. The necessity of using the terminology "form of the realization of the right to rest" instead of "types of a rest time" is substantiated. Forms of realization of legal norms, depending on the nature of their dispositions are researched and such types as fulfilment, execution and application are distinguished.
The forms of realization of the right to rest according to Ukrainian legislation are defined. The various views of modern scholars on the list of forms of realization of workers' right to rest are analyzed and the necessity of declaring periods of daily rest of employees is demonstrated.
The general rules concerning rest and meal breaks according to the Labour Code of Ukraine are analyzed and the need of detailed regulation of the specific time and duration of the rest and meal break by the state are clarified. Attention is drawn to the setting minimal duration of such a break, as in United Kingdom and France. It is emphasized on the existance of physiological breaks in legislation of a foreign country, which are important for maintaining high efficiency and a good health level of employees. Legislation of the Republic of Poland and United Kingdom concerning holidays and weekly rest days are investigated.
The importance of defining the concept and duration of daily rest in the relevant section of the Labour Code of Ukraine, as proposed by the European Union legislation is shown. The scientific literature concerning establishment of a minimal duration of daily rest lasting twelve hours to ensure adequate rest for workers who work part-time or overtime is analized. The provisions of international regulations in this sphere are taken into account.
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Vachula, Richard S., Jake R. Nelson i Anthony G. Hall. "The timing of fireworks-caused wildfire ignitions during the 4th of July holiday season". PLOS ONE 18, nr 9 (1.09.2023): e0291026. http://dx.doi.org/10.1371/journal.pone.0291026.
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Although anthropogenic climate change is causing increased wildfire activity in the United States (US), humans are also an important ignition source. Humans cause a surge in wildfire ignitions every 4th of July (Independence Day in the US) through the use of fireworks. We examine the 4th of July peak in fireworks-caused wildfire ignitions and show that their spatial distribution varies but has been heavily concentrated in the west and north central US and predominantly on tribal lands. Further, we show that the weekly timing of the 4th of July influences both the number and weekly distribution structure of fireworks-caused ignitions. We interpret these weekly and daily-scale distribution patterns of fireworks-caused ignitions to reflect the influences of human behavioral variations, culture, and fireworks regulations. For example, our analysis suggests that weekends and religious days of rest (e.g., Saturday, Sunday) have a dampening effect on the number on wildfire ignitions due to fireworks, and that weekends and the timing of work holidays likely impact the weekly distribution of fireworks-caused ignitions. Additionally, comparisons of fireworks-caused ignitions before and after the 4th of July at the daily and weekly scale likely reflect the efficacy of firework sales regulations and human behavioral tendencies towards pre-holiday impulsiveness. Given the predictability of the fireworks-caused ignitions and rising costs of wildfire mitigation, these results have several important management and policy implications.
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Miyakoshi, Naohisa, Akira Horikawa i Yoichi Shimada. "Nonsurgical Corrective Union of Osteoporotic Vertebral Fracture with Once-Weekly Teriparatide". Case Reports in Orthopedics 2015 (2015): 1–3. http://dx.doi.org/10.1155/2015/784360.
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Osteoporotic vertebral fractures usually heal with kyphotic deformities with subsidence of the vertebral body when treated conservatively. Corrective vertebral union using only antiosteoporotic pharmacotherapy without surgical intervention has not been reported previously. An 81-year-old female with osteoporosis presented with symptomatic fresh L1 vertebral fracture with intravertebral cleft. Segmental vertebral kyphosis angle (VKA) at L1 was 20° at diagnosis. Once-weekly teriparatide administration, hospitalized rest, and application of a thoracolumbosacral orthosis alleviated symptoms within 2 months. Corrective union of the affected vertebra was obtained with these treatments. VKA at 2 months after injury was 8° (correction, 12°) and was maintained as of the latest follow-up at 7 months. Teriparatide has potent bone-forming effects and has thus been expected to enhance fracture healing. Based on the clinical experience of this case, teriparatide may have the potential to allow correction of unstable vertebral fractures without surgical intervention.
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Sayar, Hamid, i Fa-Chyi Lee. "Retrospective Analysis of Weekly Administration of Bortezomib in Multiple Myeloma." Blood 106, nr 11 (16.11.2005): 5186. http://dx.doi.org/10.1182/blood.v106.11.5186.5186.
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Abstract Background: Currently the standard treatment of multiple myeloma (MM) with the proteasome inhibitor bortezomib (Velcade) is by twice weekly administration of the drug. We present a retrospective study of bortezomib therapy by weekly dosing in MM patients unable to tolerate the standard regimen. Methods: Since January 2004, five patients (3 male and 2 female, age 47 – 81) have been treated at our center by weekly, and one (male, 86) by every-two-week administration of bortezomib. This approach was selected primarily due to low performance status and/or comorbidities. All patients had failed at least one prior treatment modality. Each cycle of the weekly schedule consisted of one dose every week for two weeks, followed by two weeks of rest. Mainly for convenience purposes, two patients while stable on weekly treatment, were switched to even less frequent treatment of once every-three-weeks. Furthermore, five patients received a plain dose of 2.0 mg rather than regular dose calculation per body surface area. Results: All 5 patients on weekly schedule had an initial moderate to major response, followed by a stable course. None of them, however, achieved a complete remission. 2/5 demonstrated progression of disease after they were switched to every-three-week dosing. The patient on every-two-week treatment had an initial favorable response, and is currently being switched to the weekly schedule due to excellent tolerance. Conclusion: Our retrospective analysis indicates that weekly bortezomib therapy is a promising alternative approach to the treatment of MM in those patients intolerant to standard regimen. It seems reasonable, therefore, to attempt a larger prospective study of bortezomib administration with less frequent dosing, mainly in this group of MM patients.
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Saltz, L. B., D. Spriggs, L. J. Schaaf, G. K. Schwartz, D. Ilson, N. Kemeny, J. Kanowitz i in. "Phase I clinical and pharmacologic study of weekly cisplatin combined with weekly irinotecan in patients with advanced solid tumors." Journal of Clinical Oncology 16, nr 12 (grudzień 1998): 3858–65. http://dx.doi.org/10.1200/jco.1998.16.12.3858.
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PURPOSE In vitro synergy between cisplatin and irinotecan (CPT-11) has been reported. We designed a combination schedule of these agents to maximize the potential for synergistic interaction. PATIENTS AND METHODS To maximize the opportunity for synergy, we divided the cisplatin into four consecutive weekly treatments, followed by a 2-week rest. Each dose of cisplatin was immediately followed by a dose of irinotecan. The dose of cisplatin was fixed at 30 mg/m2/wk. The initial irinotecan dose was 50 mg/m2/wk and this was escalated by 30% increments in successive cohorts of three to six patients to establish the maximum-tolerated dose (MTD). Pharmacokinetics of irinotecan and its metabolites, SN-38 and SN-38 glucuronide (SN-38G), were analyzed. RESULTS Of 35 patients with solid tumors enrolled onto this trial, 30 were assessable for toxicity and response. The MTD for this regimen was 30 mg/m2/wk of cisplatin plus 50 mg/m2/wk of irinotecan in previously treated patients and 30 mg/m2/wk of cisplatin plus 65 mg/m2/wk of irinotecan in chemotherapy-naive patients. Neutropenia was the dose-limiting toxicity (DLT) encountered in this trial. Diarrhea was infrequent and rarely dose-limiting. Seven of 30 assessable patients achieved a partial response. No alteration in irinotecan, SN-38, or SN-38G pharmacokinetics resulted from the administration of cisplatin with irinotecan. CONCLUSION The administration of cisplatin and irinotecan on this weekly schedule provides a practical and well-tolerated regimen that has the potential to maximize any clinical synergy between the two agents. Evidence of substantial clinical activity was seen in this phase I study.
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Kletzander, Lucas, Nysret Musliu, Johannes Gärtner, Thomas Krennwallner i Werner Schafhauser. "Exact Methods for Extended Rotating Workforce Scheduling Problems". Proceedings of the International Conference on Automated Planning and Scheduling 29 (25.05.2021): 519–27. http://dx.doi.org/10.1609/icaps.v29i1.3518.
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In many professions daily demand for different shifts varies during the week. The rotating workforce scheduling problem deals with the creation of repeating schedules for such demand and is therefore of high practical relevance. This paper investigates solving this real-life problem with several new practically relevant features. This includes early recognition of certain infeasibility criteria, complex rest time constraints regarding weekly rest time, and optimization goals to deal with optimal assignments of free weekends. We introduce a state-of-the-art constraint model and evaluate it with different extensions. The evaluation shows that many real-life instances can be solved to optimality using a constraint solver. Our approach is under deployment in a state-of-the-art commercial solver for rotating workforce scheduling.
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Loren-Méndez, Mar, i Daniel Pinzón-Ayala. "El derecho al descanso del trabajador: la Ciudad Sindical de Vacaciones de Marbella". VLC arquitectura. Research Journal 5, nr 2 (31.10.2018): 91. http://dx.doi.org/10.4995/vlc.2018.8901.
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The worker’s right to rest constituted a new right in the construction of world peace after the First World War. Drawing on primary sources, the study begins with an overview of legislation ranging from the regulation of weekly weekend rest to annual holidays, analyzing public European proposals for holidays in the interwar years, distinguishing those designed to ensure rest for workers specifically within the context of the city. The newly acquired right was most warmly embraced by totalitarian regimes, converted into a prize, a charitable act, or an opportunity for indoctrination and control. Focusing on the case of Spain, the research presents the Ciudades Sindicales de Vacaciones, Trade Union Holiday Towns, as the culmination of the public promotion of rest for workers under Franco’s regime, subsequently giving way to private initiative and mass tourism. The research presents the Trade Union Holiday Town of Marbella as the ultimate prototype for a specific typology, analyzing its values through a projective approach to territory, providing new documentary evidence of its evolution and current status, and offering a reflection on the loss of values brought about by such transformations in light of findings made.
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Perez, Edith A., David W. Hillman, James A. Mailliard, James N. Ingle, J. Michael Ryan, Tom R. Fitch, Kendrith M. Rowland i in. "Randomized Phase II Study of Two Irinotecan Schedules for Patients With Metastatic Breast Cancer Refractory to an Anthracycline, a Taxane, or Both". Journal of Clinical Oncology 22, nr 14 (15.07.2004): 2849–55. http://dx.doi.org/10.1200/jco.2004.10.047.
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Purpose A pressing need exists for agents active against anthracycline- or taxane-refractory metastatic breast cancer (MBC), or both. Previous clinical trials suggested that irinotecan might have such activity. We conducted this multicenter phase II study to assess efficacy and tolerability of two irinotecan schedules. Patients and Methods MBC patients who experienced disease progression after one to three chemotherapy regimens, including at least one anthracycline- or taxane-based regimen, were randomly assigned to irinotecan in 6-week cycles comprising 100 mg/m2 weekly for 4 weeks, then a 2-week rest (weekly) or 240 mg/m2 every 3 weeks. Results The weekly arm had 52 assessable patients; the every-3-weeks arm had 51 assessable patients. In the weekly arm, the objective response (complete regression [CR] + partial regression [PR]) rate was 23% (one CR, 11 PR; 95% CI, 13% to 37%). Median response duration was 4.9 months (range, 1.9 to 15.9 months), and median overall survival was 9.7 months (95% CI, 8.0 to 14.2 months). In the every-3-weeks arm, the objective response rate was 14% (nine PR; 95% CI, 6% to 26%), median response duration was 4.2 months (range, 3.1 to 13.9 months), and median overall survival was 8.6 months (95% CI, 7.0 to 12.3 months). Treatment generally was well tolerated, especially in the weekly arm. Grade 3 to 4 adverse events with ≥ 10% incidence included neutropenia (29%) and diarrhea (17%) in the weekly arm and neutropenia (36%), vomiting (20%), dyspnea (18%), nausea (16%), and diarrhea (12%) in the every-3-weeks arm. Conclusion Irinotecan is active with good tolerability in refractory MBC. Irinotecan (especially weekly) warrants additional study as monotherapy and in combination regimens in this setting.
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Kamal, Arif, Amy Pickar Abernethy, Janet Bull, Jonathan Nicolla, Joseph Kelly, Charles Steven Stinson i Martha Adams. "What type of feedback to clinicians best improves conformance to supportive care quality measures?" Journal of Clinical Oncology 31, nr 31_suppl (1.11.2013): 102. http://dx.doi.org/10.1200/jco.2013.31.31_suppl.102.
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102 Background: Supportive care is under-addressed in oncology and an important area for quality improvement. Regular, directed feedback is an important component of effective quality management. What type of feedback yields the highest conformance to supportive care measures? Methods: Within the Carolinas Palliative Care Consortium, we conducted a series of three PDSA cycles, each one month-long, to evaluate various types of clinician-directed feedback on conformance to two supportive care measures. We collected data using a web-based, mobile health platform called QDACT-PC (Quality Data Collection Tool for Palliative Care). Every four weeks, feedback to clinicians on performance was changed in a stepwise fashion, from “no feedback” to “personal feedback” to “comparative feedback” (personal conformance compared to the rest of the Consortium). We monitored weekly changes to conformance to two quality measures: documentation of timely management of constipation and dyspnea. To meet the measures, symptoms with intensity of >3/10 on the Edmonton Symptom Assessment Scale required documentation of intervention within 24 hours. Conformance rates were calculated and compared to a historical baseline. Results: 23 providers participated in this quality improvement project, which spanned 465 patient encounters across 104 unique patients. Baseline data generated from 3/2008-10/2011 demonstrated baseline conformance to the dyspnea and constipation measures at 6% (27/457) and 4% (14/398), respectively. After addition of an electronic, prospective quality monitoring system alone (QDACT-PC), conformance increased to 93% (42/45) and 92% (23/25), respectively. With personalized, weekly feedback, these rates increased to 94% for dyspnea and 100% for constipation. Feedback comparing personal performance to the average of the rest of the Consortium further increased this to 100% for both. Conclusions: Regular, weekly feedback on performance increases conformance to supportive care quality measures. Adding comparative feedback versus other peers solidifies this effect. Duration of the effect is being evaluated.
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Fatima Khalil, Nayyar Yaqoob, Omar Ahsan, Shahida Perveen i Umer Gill. "Nutritional Assessment of Patients on Twice Weekly Maintenance Hemodialysis". Annals of PIMS-Shaheed Zulfiqar Ali Bhutto Medical University 19, nr 2 (31.05.2023): 120–24. http://dx.doi.org/10.48036/apims.v19i2.809.
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Objective: To assess the magnitude of malnutrition in hemodialysis patients in Pakistan and identify contributing factors in order to facilitate timely interventions and improve their quality of life. Methodology: A cross-sectional descriptive study was conducted at the nephrology inpatient department of Fauji Foundation Hospital Rawalpindi from April to September 2021. The study included patients aged 15–60 years, of both genders, who had been on maintenance hemodialysis twice weekly for at least six months. Data was collected by structured performa, which included patients’ demographic details, including age, gender, level of education, and daily income; the cause and duration of CKD; duration and frequency of haemodialysis Malnutrition was assessed using the Malnutrition Inflammation Score (MIS) and categorized as mild, moderate, or severe. Results: Out of the 107 enrolled patients, 90 were included in the analysis. The study revealed that only one-third of the patients had normal nutritional status, while the rest exhibited varying degrees of malnutrition. Severe malnutrition was observed in 20% of the hemodialysis population. Female gender, lower education level, and lower income were strongly associated with severe malnutrition. Conclusion: The study highlights the need to improve literacy, raise awareness about chronic kidney disease (CKD), and enhance the financial status of hemodialysis patients. These interventions can significantly improve outcomes and quality of life in this population. The findings emphasize the importance of identifying high-risk patients early on and implementing appropriate interventions to improve nutritional status and overall well-being.
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Francini, Filippo, Alessandra Pascucci, Edoardo Francini, Gianluca Bargagli, Raffaele Conca, Antonella Licchetta, Giandomenico Roviello i in. "Bevacizumab and Weekly Docetaxel in Patients with Metastatic Castrate-Resistant Prostate Cancer Previously Exposed to Docetaxel". Prostate Cancer 2011 (2011): 1–7. http://dx.doi.org/10.1155/2011/258689.
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Background. The aim of this paper was to evaluate the activity and tolerability of docetaxel (D) and bevacizumab (Bev) in patients with metastatic castrate-resistant prostate cancer (CRPC) previously exposed to D.Methods. Treatment consisted of D 30 mg/m2i.v. for four consecutive weekly administrations followed by a 2-week rest interval, in addition to Bev 5 mg/kg i.v. every 2 weeks.Results. Forty-three patients were enrolled: a PSA response was observed in 27 patients (62.7%, 95% CI: 0.41 to 0.91), and a palliative response was achieved in 31 patients (72.1%, 95%CI: 0.48 to 1.02). After a median followup of 11.3 months, only five patients had died. The regimen was generally well tolerated.Conclusion. Weekly D + biweekly Bev seems to be an effective and well-tolerated treatment option for patients with metastatic CRPC previously exposed to D-based chemotherapy.
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Vermeulen, Tyler F., Logan A. Boyd i Lawrence L. Spriet. "Dietary Macronutrient and Micronutrient Intake over a 7-Day Period in Female Varsity Ice Hockey Players". Nutrients 13, nr 7 (30.06.2021): 2262. http://dx.doi.org/10.3390/nu13072262.
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This study examined the energy, macronutrient, and micronutrient intakes of female ice hockey players over a 7-d period including game, practice, and rest days. Twenty-three female varsity players (19.0 ± 1.1 yr, 167.1 ± 6.5 cm, 67.0 ± 8.0 kg) volunteered for the study. Average total daily energy expenditure (TDEE) was estimated over the 7-day period. Average 7-day energy intake (EI) and TDEE were 2354 ± 353 and 2304 ± 204 kcal. The majority (n = 19) of athletes had an EI ≥ 90% of their estimated TDEE. Macronutrient intake was 52% carbohydrate (CHO), 32% fat, and 16% protein of total EI, although CHO intake was slightly below recommendations (5 g/kg BM/d) on game and practice (4.8 ± 1.4 and 4.5 g/kg BM/d) days. Game day EI was greater than practice and rest days. Recommended micronutrient intakes were not met by most athletes for iron, calcium, vitamin D, and potassium, and intakes were similar between game, practice, and rest days. In summary, the average EI for female varsity ice hockey players appeared adequate to meet their energy needs over a weekly cycle of game, practice, and rest days. However, these female athletes would benefit from increasing CHO intake on game and practice days and selecting foods that are rich in vitamins and minerals.
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Della Rosa, M. M., J. R. Toffaletti, M. S. Aello i J. C. Burges. "Feed bunk management effects steer performance and behaviour". Animal Production Science 60, nr 11 (2020): 1442. http://dx.doi.org/10.1071/an18614.
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Animal performance and behaviour in fattening steers using ad libitum or restricted feed-bunk management were evaluated. High store-capacity self-feeders with weekly recharge were used in ad libitum management (ADLIB), while manual twice-a-day delivery was used in restricted management (REST). Twenty-four steers were allotted to 12 pens and fed with a high corn-grain diet without roughage, and randomly assigned to one of the treatments. Animal behaviour was recorded every 5 min throughout 24 h for 3 days. No bunk-management effect was evident in bodyweight (P ≥ 0.95) or average daily gain (P = 0.91). Even though ADLIB resulted in higher dry-matter intake (P = 0.03), the animals spent less time per day eating feed than did those under REST (P < 0.01), with more eating sessions per day (P = 0.02), which were shorter (P = 0.06). Rumination time was greater (P = 0.07) under ADLIB than under REST, while the opposite was observed for time spent eating (P < 0.01). Resting time was longer in animals under ADLIB (P = 0.02), with more sessions per day (P = 0.06), than under REST. In conclusion, the two feed-bunk managements evaluated had no negative implications either for animal performance or behaviour.
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Rothenberg, M. L., J. G. Kuhn, H. A. Burris, J. Nelson, J. R. Eckardt, M. Tristan-Morales, S. G. Hilsenbeck, G. R. Weiss, L. S. Smith i G. I. Rodriguez. "Phase I and pharmacokinetic trial of weekly CPT-11." Journal of Clinical Oncology 11, nr 11 (listopad 1993): 2194–204. http://dx.doi.org/10.1200/jco.1993.11.11.2194.
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PURPOSE We conducted a phase I and pharmacokinetic trial of CPT-11 (irinotecan) to characterize the maximum-tolerated dose (MTD), toxicities, pharmacokinetic profile, and antitumor effects in patients with refractory solid malignancies. PATIENTS AND METHODS We treated 32 patients with CPT-11 administered as a 90-minute intravenous infusion every week for 4 consecutive weeks followed by a 2-week rest period. Dose levels ranged from 50 to 180 mg/m2/wk. We determined concentrations of the lactone (active) and total (lactone plus carboxylate) forms of CPT-11 and its metabolite, SN-38, in the plasma and urine of selected patients during and after drug infusion. RESULTS Grade 4 diarrhea was the dose-limiting toxicity (DLT) at the 180-mg/m2/wk dose level. Other toxicities attributed to CPT-11 included dehydration, nausea, vomiting, and asthenia. Hematologic toxicity was mild in most patients. The terminal plasma half-life for CPT-11 (total) was 7.9 +/- 2.8 hours, for CPT-11 (lactone) 6.3 +/- 2.2 hours, for SN-38 (total) 13.0 +/- 5.8 hours, and for SN-38 (lactone) 11.5 +/- 3.8 hours. We observed significant correlations between drug dose and peak plasma concentration (Cpmax) and between drug dose and area under the concentration curve (AUC) for CPT-11, but not for SN-38. CONCLUSION The MTD for CPT-11 in this patient population was 150 mg/m2/wk when administered on a weekly-times-four schedule repeated every 6 weeks. At dose levels greater than 150 mg/m2/wk, diarrhea is dose-limiting.
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Hingorani, Sunil R., William Proctor Harris, Joseph Thaddeus Beck, Boris A. Berdov, Stephanie Ann Wagner, Eduard M. Pshevlotsky, Sergei Tjulandin i in. "Final results of a phase Ib study of gemcitabine plus PEGPH20 in patients with stage IV previously untreated pancreatic cancer." Journal of Clinical Oncology 33, nr 3_suppl (20.01.2015): 359. http://dx.doi.org/10.1200/jco.2015.33.3_suppl.359.
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359 Background: Poor outcome in pancreatic cancer (PDA) has been associated with tumor stroma limiting access of chemotherapy drugs. PEGPH20 (PEG), PEGylated recombinant human hyaluronidase, which depletes hyaluronan (HA) in tumors, has demonstrated anti-tumor activity in preclinical PDA models. In a KPC model of PDA, PEG + gemcitabine (Gem) significantly prolonged survival compared to Gem alone. In Phase 1 PEG monotherapy studies, the MTD was 3µg/kg. The most common adverse events (AEs) were musculoskeletal events. Methods: This was a phase 1b study to determine the recommended phase 2 dose of PEG + Gem in patients (pts) with previously untreated Stage IV pancreatic cancer. PEG was given at 1, 1.6, or 3µg/kg IV twice weekly Wks 1–4 and weekly Wks 5–7, followed by 1 wk rest. Gem was given at 1000mg/m2IV once weekly for Wks 1–7, then 1 wk rest. Thereafter, PEG + Gem were given once weekly for 3 wks in 4-wk cycles. Dexamethasone was given pre and post PEG doses. Due to evolving SOC, the study was discontinued before initiation of the phase 2 randomization. Results: Twenty-eight pts were enrolled in the study. The majority of the patients (89%) had metastatic sites in the liver. Four, 4 and 20 pts received PEG at 1, 1.6 and 3µg/kg, respectively. The most common AEs related to PEG were muscle spasm (54%), myalgia (39%), arthralgia (29%), peripheral edema (29%), fatigue (25%), and extremity pain (18%). Median progression free survival (PFS) and overall survival (OS) were assessed and were 154 and 200 days, respectively. In an exploratory analysis, tumor biopsies from 17 pts were evaluated for HA levels (HAhigh or HAlow). 6 pts were determined to have HAhigh tumors and 11 pts had HAlow tumors. The median PFS and OS for HAhigh pts were 219 days (95% CI: 159-276) and 395 days (95% CI: 210-578). For HAlowpts median PFS and OS were 108 (95% CI: 14-163) and 174 days (95% CI: 34-293). Conclusions: PEG + Gem is generally well tolerated in advanced pancreatic cancer and shows promising clinical activity, especially in pts with HAhigh tumors. ClinicalTrials.gov Identifier: NCT01453153.
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St. James, Elizabeth A., Michael L. Schummer, Richard M. Kaminski, Edward J. Penny i L. Wesley Burger. "Effect of Weekly Hunting Frequency on Duck Abundances in Mississippi Wildlife Management Areas". Journal of Fish and Wildlife Management 4, nr 1 (1.06.2013): 144–50. http://dx.doi.org/10.3996/042012-jfwm-034.
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Abstract Management of waterfowl habitat and hunting frequency is important to sustain hunting opportunities in Mississippi and elsewhere in North America. Managers have limited scientific information regarding the effect of weekly hunting frequency on waterfowl abundance for use in developing hunting plans for public hunting areas. We divided the hunted portions of three Mississippi Wildlife Management Areas into two treatments to evaluate the effect of hunting 2 versus 4 d/wk on duck abundance. Abundance of all ducks, mallard Anas platyrhynchos, northern shoveler Anas clypeata, and green-winged teal Anas crecca were not detectably different between weekly hunting frequencies. Sanctuary use increased approximately 30% during the first 1.25 h after sunrise regardless of hunting disturbance being present or absent. Our results indicate that duck abundance did not increase with increased rest days at Wildlife Management Areas, suggesting these areas may be hunted 4 d/wk without significantly decreasing duck abundance. Sanctuaries were used daily and may be vital to attract and retain ducks on Wildlife Management Areas.
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Beirle, S., U. Platt, M. Wenig i T. Wagner. "Weekly cycle of NO<sub>2</sub> by GOME measurements: A signature of anthropogenic sources". Atmospheric Chemistry and Physics Discussions 3, nr 4 (3.07.2003): 3451–67. http://dx.doi.org/10.5194/acpd-3-3451-2003.
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Abstract. Nitrogen oxides (NO+NO2=NOx) are important trace gases in the troposphere with impact on human health, atmospheric chemistry and climate. Besides natural sources (lightning, soil emissions) and biomass burning, fossil fuel combustion is estimated to be responsible for about 50\\% of the total production of NOx. Since human activity in industrialized countries largely follows an artificial seven-day cycle, fossil fuel combustion is expected to be reduced during weekends. This "weekend effect" is well known from local, ground based measurements, but has never been analysed on a global scale before. The Global Ozone Monitoring Experiment (GOME) on board the ESA-satellite ERS-2 allows measurements of NO2 column densities. Applying sophisticated algorithms, vertical column densities (VCD) of tropospheric NO2 can be determined. We demonstrate the statistical analysis of weekly cycles of tropospheric NO2 VCDs for different regions of the world. In the cycles of the industrialized regions and cities in the US, Europe and Japan a clear Sunday minimum of tropospheric NO2 VCD can be seen. Sunday NO2 VCDs are about 25–50% lower than working day levels. Metropolitan areas with other religious and cultural backgrounds (Jerusalem, Mecca) show different weekly patterns corresponding to different days of rest. In China, no weekly pattern can be found. The presence of a weekly cycle in the measured tropospheric NO2 VCD allows the identification of anthropogenic sources. In addition, the fraction of emissions subjected to a weekly cycle (mainly transport, power generation) with respect to a constant background (all kind of natural sources, biomass burning, heavy industry) can be estimated. Furthermore, we estimated the lifetime of tropospheric NO2 by analysing the mean weekly cycle over Germany in detail, obtaining a value of about 12 h.
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Fuchs, Charles S., Melvin R. Moore, Graydon Harker, Luis Villa, David Rinaldi i J. Randolph Hecht. "Phase III Comparison of Two Irinotecan Dosing Regimens in Second-Line Therapy of Metastatic Colorectal Cancer". Journal of Clinical Oncology 21, nr 5 (1.03.2003): 807–14. http://dx.doi.org/10.1200/jco.2003.08.058.
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Purpose: Randomized trials in fluorouracil (FU)-refractory colorectal cancer demonstrate significant survival advantages for patients receiving irinotecan. We prospectively compared the efficacy and tolerability of two irinotecan regimens (once a week for 4 weeks followed by a 2-week rest period [weekly] v once every 3 weeks) in such patients. Patients and Methods: This multicenter, open-label, phase III study randomly assigned patients in a 1:2 ratio to irinotecan given either weekly (125 mg/m2) or once every 3 weeks (350 mg/m2, or 300 mg/m2 in patients who were ≥ 70 years of age, who had Eastern Cooperative Oncology Group performance status equal to 2, or who had prior pelvic irradiation). Results: With median follow-up of 15.8 months, there was no significant difference in 1-year survival (46% v 41%, respectively; P = .42), median survival (9.9 v 9.9 months, respectively; P = .43), or median time to progression (4.0 v 3.0 months, respectively; P = .54) between the two regimens. Grade 3/4 diarrhea occurred in 36% of patients treated weekly and in 19% of those treated once every 3 weeks (P = .002). Grade 3/4 neutropenia occurred in 29% of patients treated weekly and 34% of those treated once every 3 weeks (P = .35). Treatment-related mortality occurred in five patients (5.3%) receiving irinotecan weekly and three patients (1.6%) given therapy once every 3 weeks (P = .12). Global quality of life was not statistically different between treatment groups. Conclusion: Irinotecan schedules of weekly and of once every 3 weeks demonstrated similar efficacy and quality of life in patients with FU-refractory, metastatic colorectal cancer. The regimen of once every 3 weeks was associated with a significantly lower incidence of severe diarrhea.
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Petrelli, N., H. O. Douglass, L. Herrera, D. Russell, D. M. Stablein, H. W. Bruckner, R. J. Mayer, R. Schinella, M. D. Green i F. M. Muggia. "The modulation of fluorouracil with leucovorin in metastatic colorectal carcinoma: a prospective randomized phase III trial. Gastrointestinal Tumor Study Group." Journal of Clinical Oncology 7, nr 10 (październik 1989): 1419–26. http://dx.doi.org/10.1200/jco.1989.7.10.1419.
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A total of 343 patients with previously untreated metastatic measurable colorectal carcinoma were studied to evaluate the impact on toxicity, response, and survival of leucovorin-modulated fluorouracil (5-FU). A maximally tolerated intravenous bolus loading course regimen of 5-FU alone (500 mg/m2 x 5 days every 4 weeks with 25 mg/m2 escalation) was compared with a high-dose leucovorin regimen (600 mg/m2 of 5-FU with 500 mg/m2 of leucovorin weekly for 6 weeks with a 2-week rest) and with a similar low-dose leucovorin regimen (600 mg/m2 of 5-FU with 25 mg/m2 of leucovorin weekly for 6 weeks with a 2-week rest). The dose-limiting toxicity for the two 5-FU and leucovorin regimens was gastrointestinal, specifically diarrhea; severe diarrhea was seen frequently, and treatment-related toxicity was implicated in the demise of 11 of the patients (5%). Significant improvements in response rates were observed with a response rate of 33 of 109 (30.3%) on the high-dose leucovorin regimen (P less than .01 v control); 13 of 107 (12.1%) on the 5-FU control; and 21 of 112 (18.8%) on the low-dose leucovorin regimen. A trend toward longer survival in the 5-FU plus high-dose leucovorin regimen was observed. In this study, leucovorin was shown to significantly enhance the therapeutic effect of 5-FU in metastatic colorectal carcinoma.