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Artykuły w czasopismach na temat "Wb 102"
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Ashley, Rhoda L., Marie Eagleton i Natasha Pfeiffer. "Ability of a Rapid Serology Test To Detect Seroconversion to Herpes Simplex Virus Type 2 Glycoprotein G Soon after Infection". Journal of Clinical Microbiology 37, nr 5 (1999): 1632–33. http://dx.doi.org/10.1128/jcm.37.5.1632-1633.1999.
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Sera (n = 188) from 29 patients with first-episode genital herpes simplex virus type 2 (HSV-2) infections were tested by POCkit-HSV-2 and Western blot (WB) to determine the speed of seroconversion. The median time to detection of HSV-2 antibody was 13 days (range, 3 to 102 days) by the POCkit-HSV-2 test versus 13 days (range, 2 to 58 days) for WB.
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Vendrame, Stefano, Panagiotis Tsakiroglou, Aleksandra S. Kristo, Dale A. Schuschke i Dorothy Klimis-Zacas. "Wild blueberry consumption attenuates local inflammation in the perivascular adipose tissue of obese Zucker rats". Applied Physiology, Nutrition, and Metabolism 41, nr 10 (październik 2016): 1045–51. http://dx.doi.org/10.1139/apnm-2016-0160.
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Perivascular adipose tissue (PVAT) has been shown to play important roles in regulating vascular tone and linking local and systemic vascular inflammation. We examined the impact of PVAT on phenylephrine-mediated vasoconstriction in the aorta of obese Zucker rats (OZR) and their lean littermates (LZR) by comparing aortic rings with or without PVAT. Subsequently we placed OZR and LZR on a control (C) or an 8% wild blueberry (WB) diet and evaluated the effect of WB consumption on such response. PVAT-released adipokine concentrations were also measured as a function of WB diet. Maximal constrictor force (Fmax) in aortic rings without PVAT was significantly lower in OZR-C compared with LZR-C (0.41 ± 0.05 and 0.71 ± 0.06 g, respectively). Following WB diet, Fmax significantly increased in OZR (0.54 ± 0.06 g). In aortas with intact PVAT, Fmax was significantly lower in all groups (0.31 ± 0.06 OZR-C, 0.30 ± 0.05 OZR-WB, 0.29 ± 0.03 LZR-C, and 0.30 ± 0.04 g LZR-WB), but no difference was observed between treatments. PVAT concentrations of monocyte chemoactractant protein 1 (MCP-1), tumor necrosis factor alpha, and adiponectin were significantly higher in OZR compared with LZR (+102%, +108%, and +45%, respectively). Following WB diet, PVAT concentrations of interleukin-8 were significantly lower in both OZR (–37%) and LZR (–30%), while adiponectin concentrations significantly increased in both OZR (+11%) and LZR (+16%). MCP-1 concentrations significantly decreased (–31%) in the PVAT of OZR with the WB diet. WB consumption appears to attenuate local inflammation in PVAT, which may impact systemic vascular inflammation and endothelial function.
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Lal, RB, DL Rudolph, JE Coligan, SK Brodine i CR Roberts. "Failure to detect evidence of human T-lymphotropic virus (HTLV) type I and type II in blood donors with isolated gag antibodies to HTLV-I/II". Blood 80, nr 2 (15.07.1992): 544–50. http://dx.doi.org/10.1182/blood.v80.2.544.544.
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Abstract Of the 267,650 blood donations from members of the US armed forces, 72 (0.027%) were serologically confirmed to be positive for human T- lymphotropic virus type I/II (HTLVpos) and 379 (0.14%) were Western blot (WB)-indeterminate with banding pattern restricted to the proteins encoded by the gag gene only (HTLVind). To determine whether these apparently healthy HTLVind blood donors are infected with HTLV-I or HTLV-II, coded specimens from randomly selected military blood donors (n = 73) were tested for antibodies to HTLV by WB and radioimmunoprecipitation assay (RIPA) using HTLV-I (MT-2) antigens, by enzyme immunoassay using synthetic peptides representing the immunodominant epitopes of HTLV, and for sequences of proviral HTLV DNA by the polymerase chain reaction (PCR). Of the 73 HTLVind donors, none showed presence of env reactivity by HTLV WB and RIPA. Minimal reactivity was observed with synthetic immunodominant motifs derived from the env protein of HTLV-I (Env-1(191–214) and Env-5(242–257)) or HTLV-II (Env-2(187–209) and Env-20(85–102)) and gag protein (Gag-1a(102– 117) and Gag-10(364–385)). A peptide corresponding to the endogenous retroviral sequence with structural homologies to the gag protein of HTLVs (RTVLgag) reacted with antibodies not only in HTLVpos (88%) and HTLVind (42% to 66%) specimens, but also reacted with normal control subjects (60%). Furthermore, none of the 73 HTLVind specimens demonstrated presence of the HTLV genome when amplified with primers for the pol and tax/rex region. Six to 23 months from the initial test, 27 subjects still gave indeterminate WB patterns, and 13 of these repeat specimens were still negative for the presence of HTLV genome. We conclude that individuals at low risk for HTLV infection who have HTLVind WB reactivity are rarely, if ever, infected with HTLV-I or HTLV- II.
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Lal, RB, DL Rudolph, JE Coligan, SK Brodine i CR Roberts. "Failure to detect evidence of human T-lymphotropic virus (HTLV) type I and type II in blood donors with isolated gag antibodies to HTLV-I/II". Blood 80, nr 2 (15.07.1992): 544–50. http://dx.doi.org/10.1182/blood.v80.2.544.bloodjournal802544.
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Of the 267,650 blood donations from members of the US armed forces, 72 (0.027%) were serologically confirmed to be positive for human T- lymphotropic virus type I/II (HTLVpos) and 379 (0.14%) were Western blot (WB)-indeterminate with banding pattern restricted to the proteins encoded by the gag gene only (HTLVind). To determine whether these apparently healthy HTLVind blood donors are infected with HTLV-I or HTLV-II, coded specimens from randomly selected military blood donors (n = 73) were tested for antibodies to HTLV by WB and radioimmunoprecipitation assay (RIPA) using HTLV-I (MT-2) antigens, by enzyme immunoassay using synthetic peptides representing the immunodominant epitopes of HTLV, and for sequences of proviral HTLV DNA by the polymerase chain reaction (PCR). Of the 73 HTLVind donors, none showed presence of env reactivity by HTLV WB and RIPA. Minimal reactivity was observed with synthetic immunodominant motifs derived from the env protein of HTLV-I (Env-1(191–214) and Env-5(242–257)) or HTLV-II (Env-2(187–209) and Env-20(85–102)) and gag protein (Gag-1a(102– 117) and Gag-10(364–385)). A peptide corresponding to the endogenous retroviral sequence with structural homologies to the gag protein of HTLVs (RTVLgag) reacted with antibodies not only in HTLVpos (88%) and HTLVind (42% to 66%) specimens, but also reacted with normal control subjects (60%). Furthermore, none of the 73 HTLVind specimens demonstrated presence of the HTLV genome when amplified with primers for the pol and tax/rex region. Six to 23 months from the initial test, 27 subjects still gave indeterminate WB patterns, and 13 of these repeat specimens were still negative for the presence of HTLV genome. We conclude that individuals at low risk for HTLV infection who have HTLVind WB reactivity are rarely, if ever, infected with HTLV-I or HTLV- II.
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Perenha-Viana, M. C. Z., I. A. A. Gonzales, S. R. Brockelt, L. N. C. Machado i T. I. E. Svidzinski. "Serological Diagnosis of Paracoccidioidomycosis through a Western Blot Technique". Clinical and Vaccine Immunology 19, nr 4 (1.02.2012): 616–19. http://dx.doi.org/10.1128/cvi.05693-11.
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ABSTRACTParacoccidioidomycosis (PCM) is a serious infectious disease that progresses toward death if untreated. Its confirmatory diagnosis is made by the detection of the fungusParacoccidioides brasiliensisin a direct mycological examination or by histopathology. However, these techniques are of low sensitivity. Serological tests seem to be more promising. The objective of this study was to test Western blot (WB) analysis using sera from patients suspected of PCM to determine whether it represents a safe and sensitive serological technique for a rapid and effective diagnosis for this disease. Sera from 517 patients were analyzed through WB analysis and double-immunodiffusion (DID) techniques using a crude exoantigen ofP. brasiliensis339. DID gave positive reactions for 140 sera (27%) and WB for 250 sera (48.4%). All sera that had a positive reaction by DID also had a positive result with a 43-kDa glycoprotein by WB analysis. Among the 377 samples that were negative by DID, 29.1% were reactive in WB analysis. For the cutoff dilution used (1:400), a positive reaction was not observed with any of the 102 sera from patients with other diseases in regions where such diseases are endemic and 30 healthy individuals tested as negative controls. These results prove WB analysis to be a sensitive technique and suggest its inclusion among routine laboratory assays as a safe method for PCM diagnosis.
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Zakharova, I. N., N. A. Geppe, N. G. Sugyan, A. R. Denisova i I. V. Berezhnaya. "Topical etiotropic drugs in therapy of infectious inflammatory diseases of pharynx in preschool children. Results of a multicenter randomized comparative clinical trial". Russian Otorhinolaryngology 20, nr 1 (2021): 102–17. http://dx.doi.org/10.18692/1810-4800-2021-1-102-117.
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In accordance with modern clinical guidelines, systemic antibiotic therapy for infectious and inflammatory diseases of the throat is recommended only when beta-hemolytic group A streptococcus is detected. In other cases, it is advisable to use topical drugs of etiotropic, pathogenetic and symptomatic action. The combined preparation Grammidin® has a wide spectrum of etiotropic activity (antiviral, antibacterial and antifungal). Objective of the study: to assess the safety and efficacy of the use of Grammidin® for children (dosage form – metered spray) in the treatment of inflammatory diseases of the pharynx in preschool children. Materials and methods. An open comparative multicenter randomized study was carried out in two parallel groups with the participation of 160 patients aged 3–5 years with an infectious-inflammatory disease of the pharynx of nonstreptococcal etiology. The disease was established clinically by the presence of: a symptom of «sore throat» according to the Wong-Baker (WB) scale, as well as two or more local signs of acute inflammation of the oropharynx (hyperemia of the pharyngeal mucosa, edema of the pharyngeal mucosa, edema of the soft tissues of the posterior and lateral pharyngeal walls, an increase in lymphoid granules of the posterior pharyngeal wall and lateral columns, swelling of the uvula) according to pharyngoscopy. The randomized patients received Grammidin® for children or Hexoral® for 7 days according to the instructions for medical use. Safety was assessed by the incidence of adverse events (AEs) and by monitoring vital signs (body temperature, blood pressure, respiration and heart rate) with monitoring of blood and urine tests. Efficacy was assessed by the decrease in mean disease severity (modified TSS) at visit 2 from baseline – the primary endpoint. Changes were used as secondary endpoints: the severity of the disease (TSS scale), the severity of the sore throat symptom (WB scale), the severity of each of the catarrhal symptoms initially identified according to pharyngoscopy data, the proportion of patients with no sore throat (WB scale), the proportion of patients with the absence of all catarrhal phenomena (pharyngoscopy) at visits 2 and 3. Results. Primary efficacy endpoint: change in mean disease severity on the TSS scale at Visit 2 from baseline in Group 1 was –1,80 (95% CI –1,98 – –1.61) points and –1,31 (95 % CI –1,50 – –1,12) points - in group 2 (p = 0.003). Secondary performance endpoints. According to the analysis of variance in Group 1, there was a statistically significant predominance of the therapeutic effect throughout the treatment in relation to the severity of the disease on the Total Symptoms Score (TSS) scale (p = 0,006), the severity of sore throat on the WB scale (p = 0,006), as well as the severity of individual signsof the disease: «Hyperemia of the pharyngeal mucosa» (p = 0,036) and «edema of the pharynx» (p = 0,037). The rates of relief of symptoms: «the severity of lymphoid granules of the posterior pharyngeal wall and lateral columns» and «uvula edema» were similar in both groups. The proportion of children with no sore throat at visit 2 was statistically significantly different: 46 and 29% for Group 1 and Group 2, respectively (p = 0,022). Safety assessment. In the course of the study, 1 child was registered in each group who developed 1 AE of mild severity, had a doubtful connection with the study drugs, did not require their cancellation and additional therapy, and spontaneously ended without consequences by visit 3. Conclusions. The combined drug Grammidin® for children in the form of a metered spray was well tolerated by children aged 3–5 years and according to a number of main criteria of efficacy (total severity of symptoms of the disease, sore throat, hyperemia and swelling of the pharyngeal mucosa) showed a pronounced and statistically significant advantage in speed and severity effect over a monocomponent preparation containing hexetidine in the form of an aerosol.
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Reshef, Ran, Rosemarie Mick, Pavel Vassilev, Jacqueline Smith, Elizabeth Hexner, Alison W. Loren, Noelle V. Frey i in. "Whole Blood Donor Chimerism At Day 30 After Reduced Intensity Conditioned Allogeneic Stem-Cell Transplantation Predicts Disease Relapse, and Is Strongly Associated with Pretransplant Lymphodepletion". Blood 118, nr 21 (18.11.2011): 1939. http://dx.doi.org/10.1182/blood.v118.21.1939.1939.
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Abstract Abstract 1939 Background: RIC SCT relies heavily on graft-versus-tumor alloreactivity, and relapse remains a major barrier to a favorable outcome. Early prediction of relapse would allow early intervention such as donor lymphocyte infusions (DLI), but factors that predict relapse and methods for detection of minimal residual disease are often disease specific and not standardized. The level of donor-recipient chimerism has been associated with both graft rejection and relapse, but the optimal timing, desired level, and predictive value of chimerism testing in RIC SCT are unclear. Furthermore, the clinical utility of whole blood (WB) vs T-cell chimerism is not well defined, particularly after RIC SCT. Methods: We aimed to assess the predictive value of early WB and T-cell chimerism on the incidence of relapse in SCT pts receiving a uniform RIC regimen for hematologic malignancies. Between August 2006 and May 2011, 120 consecutive patients (pts) underwent allogeneic SCT following conditioning with fludarabine 120mg/m2 and busulfan i.v. 6.4 mg/kg. Pts were not treated with pre-emptive DLI, but could receive DLI for relapse. Hematopoietic chimerism was determined by DNA genotyping of short tandem repeats. Chimerism was determined on WB and then on enriched T-cells, obtained by selection using CD3-labeled magnetic beads. We conducted a cumulative incidence analysis of relapse, using day 30 as a landmark to determine the predictive properties of chimerism studies obtained at that time. Results: The 1-yr cumulative incidence of relapse in this cohort was 48.3 ± 4.7%, and the median time to relapse was 102 days (range 16–566 days), highlighting the importance of early monitoring. 68 pts were in remission and had evaluable chimerism data on day 30; importantly, the 1-year incidence of relapse was not different between pts who did and did not have day 30 chimerism measured (50.2 ± 6.5% vs. 42.9 ± 7.2%, P=0.45). Median follow up was 238 days (range 75–1420). Median age was 61 (range 21–76) and 56% were male. Underlying diseases were AML (24), MDS (13), NHL (10), myelofibrosis (6), CTCL (4), Hodgkin (3), myeloma (3), CLL (2), aplastic anemia (2), CML (1). Pts received a peripheral blood stem cell graft (67) or bone marrow (1), harvested from a matched related (30) or unrelated (38) donor. A single antigen mismatch was present in 6 cases. GVHD prophylaxis was tacrolimus (55) or cyclosporine (13) based. Median WB donor chimerism at day 30 was 96% (range 31–100%). A cumulative incidence analysis of relapse from day 30 revealed that day 30 WB chimerism had a significant association with relapse (HR 0.97, 95% CI [0.95–0.99], P=0.0011), reflecting a 3% decrease in risk of relapse for each 1% increase in chimerism. Risk of relapse according to different day 30 chimerism levels is displayed in figure 1. Using a day 30 chimerism cutoff of 95%, we found a significant association with incidence of relapse (HR 0.29, 95% CI [0.15–0.57), P=0.0003). Pts who were alive without relapse at the end of follow-up had a significantly higher chance of >= 95% day 30 WB chimerism compared to pts who relapsed (88.9% vs. 45.5%, P=0.002). In 38 pts with myeloid diseases, there was a significant association between day 30 WB chimerism and risk of relapse (HR 0.97, 95% CI [0.96–0.99], P=0.00065), while in 22 pts with lymphoid diseases, an association did not reach statistical significance (HR 0.93, 95% CI [0.84–1.00], P=0.09). Median T-cell chimerism was 70% in the 49 evaluable pts with these measurements (range 26–99%). T-cell chimerism on day 30 did not predict relapse (HR 1.0, 95% CI [0.98–1.02], P=0.95). We analyzed potential associations between day 30 WB chimerism and various transplant and patient characteristics. A higher chimerism level was significantly associated with lower day 0 lymphocyte count (P=0.004) and lower preconditioning lymphocyte count (P=0.01), but was not associated with recipient or donor age, cell doses, busulfan levels, disease type and donor type. The day 0 lymphocyte count was also a strong predictor of relapse (HR 6.87, 95% CI [6.56–7.04], P=0.00035). Conclusions: Whole blood and not T-cell chimerism at day 30 is predictive of relapse after RIC SCT. WB chimerism is strongly associated with lower lymphocyte counts before and after the conditioning regimen. These data highlight the importance of adequate lymphodepletion and can be useful in designing future trials testing pre-emptive interventions to prevent relapse after RIC SCT. Disclosures: No relevant conflicts of interest to declare.
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Uchida, S., i K. Tagami. "Iodine transfer from agricultural soils to edible part of crops". Proceedings in Radiochemistry 1, nr 1 (1.09.2011): 279–83. http://dx.doi.org/10.1524/rcpr.2011.0048.
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Abstract Information about the distribution and cycling of stable iodine (I) in the environment is useful for dose estimation from its long-lived radioiodisotpe, 129I, which is one of the most critical radionuclides to be managed for the safe disposal of nuclear fuel waste. The soil-to-plant transfer factor (TF) is an important parameter to predict internal radiation exposure pathways through the food chains using mathematical models. Therefore, we have measured stable I and bromine (Br) for comparison, in 142 crop samples and associated agricultural field soil samples collected throughout Japan. The crops were classified into eight groups, i.e. leafy vegetables, white part of leeks, fruit vegetables, tubers, root crops, legumes, wheat and barley (WB), and rice. The results showed that Br and I concentrations were higher in upland field soil samples than in paddy field soil samples. However, when we compared TF values of WB and brown rice, no statistical difference was observed. The highest geometric mean of TF for I, 1.4 × 102, was obtained for leafy vegetables and fruit vegetables and that for Br, 1.5, was for fruit vegetables. TF for I was much lower than Br, as reported previously, maybe due to their different chemcial forms in soil and uptake behaviors by plant roots.
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Bischof-Delaloye, Angelika, Cristian Antonescu i Anton Hagenbeek. "Dosimetric Analysis of 90Y-Ibritumomab Tiuxetan (Zevalin®) Given as Consolidation of First Remission in Patients with Advanced-Stage Follicular Lymphoma in the International Phase 3 First-Line Indolent Trial (FIT)." Blood 110, nr 11 (16.11.2007): 3415. http://dx.doi.org/10.1182/blood.v110.11.3415.3415.
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Abstract Yttrium-90 (90Y)-ibritumomab tiuxetan (Zevalin) is an anti-CD20 monoclonal antibody immunoconjugate linked to the pure beta-emitting 90Y radioisotope, which is known to allow targeted delivery limiting normal tissue exposure. As part of the international, phase 3 randomized First-line Indolent Trial (FIT) evaluating the efficacy of Zevalin consolidation compared with observation alone in patients (pts) with advanced stage follicular lymphoma achieving a response to first-line therapy, we investigated the radiation exposure of pts in the Zevalin arm for whom dosimetry data were available. Among the 414 pts enrolled in the trial (age ≥18 yrs, normal peripheral blood cell counts, <25% bone marrow involvement with lymphoma), 70 had a diagnostic scan with 111In-ibritumomab tiuxetan. Dosimetry was not completed in 1 pt. In addition to local dosimetry, central dosimetry was performed by a single experienced nuclear medicine physician in 57 of the 69 pts, including 21 pts in one participating hospital (I) and 36 evaluated in a central facility (II). All pts were injected with 185 MBq 111In-ibritumomab tiuxetan after infusion of rituximab (250 mg/m2) on day -7. At least 3 simultaneous anterior and posterior whole body (WB) scans were performed 15–45 min, 3–6 hrs, 1, 3–4 and 6 days after injection. Blood samples were drawn at corresponding intervals. Using the region of interest (ROI) technique, WB and organ (lungs, liver, spleen, kidneys) radioactivity was estimated from the geometric mean of anterior and posterior ROI counts. Whole blood aliquots were counted, normalized and decay corrected. WB, organ and red marrow (RM) radiation absorbed doses were calculated using the decay constant for 90Y and the projected activity (14.8 MBq/kg) with the MIRDOSE3 software. Median dose in the 57 pts evaluated by central dosimetry was 102 cGy (range 28–327) to RM and 74 cGy (range 46–106) to WB. Radiation exposure was within the protocol-defined upper limits to normal organs (2000 cGy) in all pts and to RM (300 cGy) in all but 2 pts. In one pt, the RM dose was 85175 cGy by local dosimetry, but 94 cGy by central dosimetry; the pt was treated without complications. In the other pt, the RM dose was 327 cGy by central dosimetry, but 155 cGy by local. Average RM exposure was similar between pts with grade 3–4 neutropenia and/or thrombocytopenia and those with grade 0–2. A larger percentage (45%) of the 40 pts with grade 3 or 4 neutropenia had above-average RM radiation dose compared with 18% of the 17 pts with grade 0–2, whereas, the percentage of pts with above-average WB radiation dose was comparable in both groups (42% and 41%, respectively). Overall, neither WB nor RM radiation dose was correlated with hematologic toxicity (Spearman correlation). These findings are consistent with published data (Wiseman et al J Nucl Med2003;44:465–474), and suggest that Zevalin is safely administered in pts with low tumor burden. Our study confirms that radiation exposure with Zevalin treatment is within safe limits to normal organs and that hematologic toxicity does not correlate with RM radiation dose estimates.
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WELSBY, P. "Occupational hazards to hospital personnelPatterson WB, Craven DE, Schwartz DA, Nardell EA, Kasmer J, Noble J. Ann Intern Med 1985; 102, 658–680". Journal of Infection 11, nr 3 (listopad 1985): 284. http://dx.doi.org/10.1016/s0163-4453(85)93954-4.
Pełny tekst źródłaRozprawy doktorskie na temat "Wb 102"
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Mzizi, Nompumelelo Mzizi. "Development of a RT-PCR-ELISA Wuchereria bancrofti Detection Assay for the Monitoring Of Mosquito Vector Infection and Infectivity". Scholar Commons, 2016. http://scholarcommons.usf.edu/etd/6334.
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Lymphatic filariasis (LF) is an incapacitating disease caused by three filarial nematodes belonging to the family Onchocercidae, namely Brugia timori, Wuchereria bancrofti and Brugia timori. An estimated 90% of lymphatic filariasis cases globally are caused by Wuchereria bancrofti. To evaluate the success of the Global Program to eliminate Lymphatic Filariasis it is essential to monitor the frequency of larval infection in the mosquito vector. Molecular methods to detect Wuchereria bancrofti DNA in mosquitoes have been in existence since 1996. However these methods have not been widely adopted due to the high cost associated with them and the inability of these assays to distinguish between immature and infectious stages in the mosquito vector. The overall aim of this project was to modify, as previously described in literature, the Laney real time PCR assay to permit it to be used in an end point Reverse Transcriptase (RT)-PCR ELISA format. The endpoint PCR-ELISA uses inexpensive conventional thermocyclers and inexpensive reagents and probes. To accomplish this overall goal the specific objectives were to produce a positive control RNAs for Wb-cut-1.2 L3 specific RT-PCR and Wb-TPH RT-PCR that detects any stage of the parasite, and to adapt the detection of both transcripts to a PCR-ELISA format. Positive RNA controls were prepared and purified using template cDNA made available through FR3, subsequent development and optimization of the RT PCR ELISA was achieved through the adaptation of the Onchocerca volvulus O150 PCR ELISA protocol.
We found a 16-fold difference in the limit of detection between the ELISA assay and conventional end point RT-PCR when we did a 2-fold dilution series of PCR products for both Wb-Cut-1.2 and Wb-TPH. This indicates that our assay was 16 times more sensitive than the use of regular agarose gel electrophoresis to analyze PCR products. The limit of detection with ELISA and gel analysis were comparable when a 10-fold dilution series of the positive control RNA template was done. The RT-PCR ELISA takes a day to complete and up to three 96 well plates a day can be processed compared to the limited number of samples that can be analyzed by gel electrophoresis a day. It is anticipated that our assay will be used in the molecular xenomonitoring of Wuchereria bancrofti providing earlier time-point assessments of LF infection in endemic areas. In areas that were once endemic, our diagnostic tool will play a pivotal role in monitoring LF resurgence.
Książki na temat "Wb 102"
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Saik, Lim Eric Kian, Loke Yoon Kong i Thompson Alastair M, red. Medicine and surgery: An integrated textbook. Edinburgh: Churchill Livingstone, 2007.
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L, Sackett David, red. Evidence-based medicine: How to practice and teach EBM. New York: Churchill Livingstone, 1997.
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Royal Society of Medicine (Great Britain), red. Systematic reviews to support evidence-based medicine: How to review and apply findings of healthcare research. Wyd. 2. London: Hodder Annold, 2011.
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Gordon, Guyatt, Rennie Drummond, Evidence-Based Medicine Working Group i American Medical Association, red. Users' guides to the medical literature: A manual for evidence-based clinical practice. Chicago, IL: AMA Press, 2002.
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1956-, Nerlich Brigitte, Elliott Richard 1982- i Larson Brendon, red. Communicating biological sciences: Ethical and metaphorical dimensions. Burlington, VT: Ashgate, 2009.
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undifferentiated, Alistair Gray. Evidence-Based Practice: A Primer for Health Care Professionals (Evidence-Based Practice). Churchill Livingstone, 2005.
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(Editor), John P. Geyman, Richard A. Deyo (Editor) i Scott D. Ramsey (Editor), red. Evidence-Based Clinical Practice: Concepts and Approaches. Butterworth-Heinemann, 2000.
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Johnsen, Berit, red. International Classroom Studies of Inclusive Practises: Comparing Teaching-Learning Processes. Cappelen Damm Akademisk, 2020. http://dx.doi.org/10.23865/noasp.122.
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This anthology is addressed to anyone searching for examples of individually tailored inclusive practices in the community of the class, with a critical view of their successes, shortcomings and obstacles. The book is divided into three parts: Part One contains articles that outline important aspects of the research cooperation. Part Two presents individual summaries of findings from each of the seven studies. Part Three consists of the joint comparative research report. This is the third and final anthology related to the international comparative research cooperation project WB 04/06: Development towards the Inclusive School: Practices – Research – Capacity Building.
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Tintinalli's Emergency Medicine: A Comprehensive Study Guide. McGraw-Hill Education, 2019.
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Tintinalli's Emergency Medicine: A Comprehensive Study Guide, Seventh Edition. McGraw-Hill Education / Medical, 2010.
Znajdź pełny tekst źródłaCzęści książek na temat "Wb 102"
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Delmote, P., S. Pinguet i F. Bieth. "Performances of a Compact, High-Power WB Source with Circular Polarization". W Ultra-Wideband, Short-Pulse Electromagnetics 10, 239–50. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-9500-0_22.
Pełny tekst źródłaStreszczenia konferencji na temat "Wb 102"
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Horellou, M. H., C. Capelle, T. Lecompte, C. Kaplan, C. Lecrubier, J. M. James, R. Le Menn, J. Y. Muller i M. Samama. "PSEUDO-THROMBOCYTOPENIA ASSOCIATED WITH AN ANTICOAGULANT INDEPENDENT IgM PLATELET AGGLUTININ IN A PATIENT WITH PROLONGED BLEEDING TIME". W XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643975.
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An original observation of platelet agglutination was found in a 63 y.o. man during 5 years following, without spontaneous bleeding. Low platelet counts (10 × 109/liter) and large agglutinates were observed on blood specimens collected into EDTA (1 to 15 mg/ml whole blood WB), citrate (1/10 volume citrate 0.11 M), sodium heparin (100 units/ml WB), citrate plus acetyl salicylic acid (5 to 100 mg/ml WB), citrate plus prostacyclin (Upjohn 10−5 to 10−6 M)? and buffering anticoagulant (0.8 M citrate, pH 4.65). Low platelet count and large agglutinates were also observed in capillary blood obtained by finger puncture kept at 22° or 37°C. All techniques revealed significant clumping making assessment of overall platelet number impossible. Bleeding time Ivy horizontal incision is longer than 20 minutes.Patient's serum induced normal platelets agglutination up to a 1/512 dilution at 22°and 37°C temperature. Lack of agglutination after treatment of the serum by IgM and indirect immunofluorescence tests identified the IgM nature of the agglutinating factor. This antibody reacted with Glanzmann thrombasthenia platelets ruling out the IIb/IIIa complex as the target of this agglutinin.There was no evidence of platelet activation following agglutination of autologous or alldgenic platelets : electronic microscopy of native blood platelets clumps did not show any sign of activation, and plasma level of B-thromboglobulin was normal in this patient. Normal platelets agglutination by patient's serum was not accompanied with ATP secretion (luciferin-luciferase).This IgM agglutinin was associated with elevation of IgM (700 mg/dl) without clinical or biological signs of auto-immune disease.No similar case with irreversible platelet agglutination in both capillary or venous blood has been reported before. The significance of the observation remains obscure.
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Qian, Lu, i Xuegang Wang. "A new Wideband Digital Array Radar (WB-DAR) experiment system". W 2014 IEEE Region 10 Symposium. IEEE, 2014. http://dx.doi.org/10.1109/tenconspring.2014.6863073.
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Ohara, Junichi, i Shigeru Koyama. "Falling Film Evaporation of Binary Refrigerant Mixture in Vertical Rectangular Minichannels Consisting of Serrated-Fins". W ASME 2014 12th International Conference on Nanochannels, Microchannels, and Minichannels collocated with the ASME 2014 4th Joint US-European Fluids Engineering Division Summer Meeting. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/icnmm2014-22184.
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The characteristics of heat transfer are investigated experimentally for the vertical falling film evaporation of binary refrigerant mixture HFC134a/HCFC123 in a rectangular minichannels consisting of offset strip fins. The refrigerant liquid is uniformly supplied to the channel through a distributor. The liquid flowing down vertically is heated electrically from the rear wall of the channel and evaporated. To observe the flow patterns during the evaporation process directly, the small circular window is set at the center of every section on the front wall. The experimental parameters are as follows: the mass velocity G = 28∼70 kg/(m2s), the heat flux q = 30∼50 kW/m2 and the pressure P ≈ 100∼260 kPa. In the case of large mass velocity G ≥ 55 kg/(m2s), the value of heat transfer coefficient becomes lower with increase of mass fraction of low-boiling component HFC134a wb in the region of x ≥ 0.3. The main reason for this inclination of α is considered that shearing force acts on the liquid-vapor interface becomes smaller because of vapor velocity suppressed by higher pressure in the test evaporator in the case of larger mass fraction of low-boiling component. Additionally, mass diffusion resistances formed on each side of vapor and liquid phase along the liquid-vapor interface are considered as a possible cause of reduction in the heat transfer coefficient α with increase of mass fraction wb. In the region of x ≥ 0.8, α descend rapidly despite the difference in the value of wb. It can be attributed to dry-out state of heat transfer area. Heat transfer coefficient derived from experiments is compared with that calculated from empirical correlation equation for heat transfer coefficient of pure refrigerant in a vertical falling film plate-fin evaporator.
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Nagal, Rachana, Manish Kumar i Rahul Jain. "Optimal real time DSP implementation of Extended Adaptive Multirate Wide Band (AMR-WB+) Speech Codec". W TENCON 2008 - 2008 IEEE Region 10 Conference (TENCON). IEEE, 2008. http://dx.doi.org/10.1109/tencon.2008.4766697.
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Harris, Howard, i Marc Calabrese. "On-Line Detergent Fluid Evaluation on a TF4OB Gas Turbine Engine". W ASME 1994 International Gas Turbine and Aeroengine Congress and Exposition. American Society of Mechanical Engineers, 1994. http://dx.doi.org/10.1115/94-gt-452.
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This paper presents results, evaluation, and comparisons between eleven on-line water wash detergents and water that were tested on a TF40B gas turbine engine. Comparisons were based on test cell data, field use data, environmental requirements, cost and U.S. Navy specification MIL-C-85704 Rev B, “Cleaning Compound, Turbine Engine Gas Path.” Detergents tested were: Turbotect 920 and 950, B&B TC-100, ZOK-27, R-MC, Fyrewash WB and SB. Turco 6783-50, Turboclean 2, EDC R-2701 and TEC 20. Fyrewash SB was the only solvent based online detergent tested. All other detergents were aqueous based.
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Lall, Pradeep, i Sungmo Jung. "Reliability Evaluation of Cu-Al WB in High Temperature and High Current Applications". W ASME 2021 International Technical Conference and Exhibition on Packaging and Integration of Electronic and Photonic Microsystems. American Society of Mechanical Engineers, 2021. http://dx.doi.org/10.1115/ipack2021-75890.
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Abstract High reliability harsh environment applications necessitate a better understanding of the acceleration factors under operating stresses. Automotive electronics has transitioned to the use of copper wire for first level interconnects. A number of copper wire formulations have emerged including palladium coated copper and gold-flash palladium coated copper. The corrosion reliability of copper wire bonds in high temperature conditions is not yet fully understood. The EMC used to encapsulate chips and interconnects can vary widely in formulation, including pH, porosity, diffusion rate, composition of contaminants and contaminant concentration. To realistically represent the expected wirebond reliability, there is need for a predictive model that can account for environmental conditions, operating conditions, and exposure to EMCs. In this paper, different EMCs were studied in a high-temperature-current environment with temperature range of 60°C–100°C under current of 0.2A–1A. The diffusion kinetics based on the Nernst-Planck Equation for migration of the chlorine ions has been coupled with the Butler-Volmer equation for corrosion kinetics to create a Multiphysics model. Polarization curves have been measured for copper, aluminum and intermetallics under a number of pH values, and chlorine-ion concentrations. Tafel parameters have been extracted through measurements of the polarization curves.
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Koshino, Tetsushi, Mohamed S. Aly-Hassan i Hiroyuki Hamada. "Jute Fiber Reinforced Polymeric Composites With Flexible Interphase". W ASME 2012 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/imece2012-87775.
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In this research, the flexible interphase concept was introduced to enhance the poor mechanical properties of jute fiber reinforced unsaturated polyester matrix composites. The jute cloth reinforcement was obtained from recycled coffee bags. These jute cloths after washing by water and drying were soaked in mixture of Polybutadiene Epoxydied as flexible resin and acetone for 10 seconds. Several mixtures consist of 0, 2, 3.5, 5 and 8 wt% of Polybutadiene Epoxydied and 100, 98, 96.5, 95 and 92 wt% of acetone, respectively, to form flexible interface around the jute fibers. Jute cloth reinforced unsaturated polyester matrix composites with different flexible interphase incremental weight ((Wa-Wb)/Wb) ratios were fabricated by hand lay-up method and examined by a series of mechanical tests. The mechanical testing including tensile, bending, Izod strength impact and drop impact was carried out for these composites to evaluate the effect of the flexible interphase and acetone on the jute cloth composites. The flexible interphase succeed to control the mechanical properties of jute fiber reinforced unsaturated polyester matrix composites. Inserting flexible interphase between unsaturated polyester matrix and jute fibers leads to smooth fluctuation, less matrix cracking, in the second part after the knee point of each stress-strain curve as exhibited in composites with higher flexible interphase incremental weight ratio. This means not only the brittle matrix but also interface/interphase dominates the multiple matrix cracking behavior in jute cloth reinforced unsaturated polyester matrix composites. Inserting flexible interphase between unsaturated polyester matrix and jute fibers leads to less number of multiple cracking as shown in the second portion of flexural stress-displacement curve. This means the number of multiple cracking are dominated by flexible interphase. The impact strength of jute cloth reinforced unsaturated polyester matrix composites with flexible interphase incremental weight ratio of 1.2% is higher than that of jute cloth reinforced unsaturated polyester matrix composites without flexible interphase by about 45%. The impact energy after maximum load has increased significantly with all flexible interphase incremental weight ratios.
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Demos, S. G., J. Ullman, Edward J. Celmer, Margaret Zurawska-Szczepaniak i R. R. Alfano. "Polarization Temporal Gating of Light Propagating in Highly Scattering Medium". W International Conference on Ultrafast Phenomena. Washington, D.C.: Optica Publishing Group, 1996. http://dx.doi.org/10.1364/up.1996.wb.5.
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A light pulse propagating in a highly scattering medium experiences multiple scattering lossing coherence and polarization and leading to a much broader temporal profile.1-4 In this work we measure the degree of polarization of linearly polarized laser pulses emerging after propagation in polystyrene microsphere solutions or human breast tissues. The temporal profiles of the parallel and perpendicular polarization components of the emerging light pulses differ for over 100 ps following the ballistic component. These results demonstrate that polarization can be used for time-gating the early-arriving component of the output pulse with gate time duration of ≈100 ps.
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Emmitt, G. D., J. Dieudonné, S. A. Wood i L. Wood. "Simulation Space-Based Doppler Lidar Wind Measurements Using Ground-Based Single Shot Observations". W Optical Remote Sensing of the Atmosphere. Washington, D.C.: Optica Publishing Group, 1993. http://dx.doi.org/10.1364/orsa.1993.wb.5.
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Both single-agency and multi-agency efforts are currently underway to put a Doppler lidar wind sounder into space within the next decade. Justification for this ambitious project rests mainly in the universally recognized need to provide direct measurements of the winds as input to both climate studies and forecast models. Expectations of success are based heavily upon ground-based observations as well as a few airborne observations. While the space-based observations will be taken at 5-10 Hz providing samples with a spatial separation of 50 to 70 kilometers within the earth's atmosphere, both the ground-based and airborne observations have been acquired primarily at 20 to 100 hertz providing a shot density of many samples per square meter resolution. Furthermore, many of the wind velocity estimates derived from these ground-based and airborne instruments have been acquired by using a poly-pulse pair technique involving 20 to sometimes 100 pulses. Currently there is very little in the way of data that is acquired in a single shot mode and processed to achieve resolution, both in space and time, that will approximate that which is achievable with a space-based system.
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Burrows, P. E., S. R. Forrest i F. F. So. "Dependence of the Performance of Vacuum Deposited Organic Light Emitting Diodes on Layer Thickness and Composition". W Organic Thin Films for Photonic Applications. Washington, D.C.: Optica Publishing Group, 1993. http://dx.doi.org/10.1364/otfa.1993.wb.2.
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Efficient green electroluminescence from an organic double-layer device between two electrodes was first reported by Tang and Van Slyke [1,2]. Subsequently, there has been considerable interest in using various fluorescent organic molecules in similar structures to produce electroluminescence in different spectral regions. Also, more complex, triple layer "double heterostructure" devices have been reported[3]. However, although devices emitting throughout the visible spectrum have been successfully fabricated [1,4,5], there is a lack of quantitative information relating the organic layer thickness and heterojunction properties to device performance.
Raporty organizacyjne na temat "Wb 102"
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Progress Report (2014-2015) of the MDB Working Group on Sustainable Transport. Inter-American Development Bank, grudzień 2015. http://dx.doi.org/10.18235/0006461.
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1. In the third year of the Multilateral Development Banks¿1 (MDBs) Joint Statement of 2012, our eight MDBs are on target to meet the goal of the Commitment to Sustainable Transport (hereafter the Rio+20 Commitment) to provide more than $175 billion of loans and grants for transport in developing countries over the coming decade (2012-2022). Collectively, in 2014, about $20 billion of new funding for transport projects was added to the $20 billion approved in the first year of our Commitment (2012) and $25 billion approved in 2013. 2. This $20 billion in funding comprised more than 193 approvals. 2 including: 103 for roads, 32 for urban transport , 14 for rail; 9 for airports. 6 for inland waterway and maritime projects, 29 for other transport projects. 3. In addition, more than 192 technical assistance (TA) projects were approved to support policy development, research and capacity building. 4. Increasingly, our MDBs are supporting more sustainable types of transport projects¿transport that is accessible, affordable, efficient, financially sustainable, environmentally friendly, and safe. Under a common reporting framework, our institutions have continued to make progress in assessing the sustainability of our transport lending in economic, social, and environmental terms. 5. In 2014, all MDBs completed an assessment of the sustainability of our entire annual transport lending, up from four MDBs in the year before. ADB used the Sustainability. Appraisal Rating Framework (STAR) while six MDBs used a modified version of STAR. WB used its own internal methodology. For MDBs that applied STAR or a modified STAR, a common four-point scale was used although the results are not yet fully comparable. Further efforts will be made to improve the comparability of ratings between the MDBs in the future. 6. The MDB Working Group on Sustainable Transport (WGST) identified quantitative indicators of project outputs and outcomes that can be used to complement the sustainability assessment. In this regard, relevant output and outcome indicators with readily available data are reported in the ¿In numbers¿ feature of each MDB, e.g. kilometer (km) of roads built or upgraded, km of railways built or upgraded, volume of transport mitigation investment, and percentage of road projects with road safety components. Discussions are ongoing to further harmonize reporting on indicators. 7. The year 2015 marks several important milestones in the international dialogue on development which are directly relevant to sustainable transport. These include completion of the 2030 Agenda for Sustainable Development and adoption of the new Sustainable Development Goals (SDGs), the 21st Conference of the Parties to the United Nations Framework Convention on Climate Change, and the Second Global Ministerial Conference on Road Safety to mark the mid-point of the United Nations Decade of Action for Road Safety. 8. The newly approved SDGs are expected to raise the attention given to addressing the different dimensions of sustainable transport, which will be conducive to the role of MDB-financed sustainable transport projects and programs. Our MDBs expect to take part in the process of deciding the indicators to be used for tracking progress on meeting the SDG targets and will make efforts to incorporate the indicators in our work.